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Neonate & ventilator

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https://www.readbyqxmd.com/read/29910548/clinicoetiological-pattern-and-outcome-of-neonates-requiring-mechanical-ventilation-study-in-a-tertiary-care-centre
#1
Mohini Yadav, Gauri Chauhan, A K Bhardwaj, P D Sharma
The clinical and etiological pattern of ventilated newborns, their outcome in relation to morbidity and mortality was studied with 50 ventilated newborns, including outborns. M:f ratio was 2.1:1. The most common gestational age 28-36 weeks (60%) and mostly were appropriate for gestational age (66%). Survival rate 40% (20/50) being directly proportional to the gestational age and intrauterine growth pattern ( P < 0.01). Babies by LSCS Lower Segment Cessarian Section survived more than born by normal vaginal delivery (46...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29907334/risk-and-benefits-of-bubble-continuous-positive-airway-pressure-for-neonatal-and-childhood-respiratory-diseases-in-low-and-middle-income-countries
#2
REVIEW
Osayame A Ekhaguere, Amsa B Mairami, Haresh Kirpalani
Over 80% of the global burden of childhood deaths occur in Low- and Middle-Income Countries (LMIC). Of the leading causes of death, respiratory failure is common to the top three. Bubble Continuous Positive Airway Pressure (bCPAP) is a standard therapy considered safe and cost effective in high resource settings. Although high-quality trials from LMIC are few, pooled available trial data considered alongside studies from high-income countries suggest that bCPAP: (i) reduces mortality; (ii) reduces the need for mechanical ventilation; and (iii) prevents extubation failure...
May 4, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29903721/visual-attention-on-a-respiratory-function-monitor-during-simulated-neonatal-resuscitation-an-eye-tracking-study
#3
Trixie A Katz, Danielle D Weinberg, Claire E Fishman, Vinay Nadkarni, Patrice Tremoulet, Arjan B Te Pas, Aleksandra Sarcevic, Elizabeth E Foglia
OBJECTIVE: A respiratory function monitor (RFM) may improve positive pressure ventilation (PPV) technique, but many providers do not use RFM data appropriately during delivery room resuscitation. We sought to use eye-tracking technology to identify RFM parameters that neonatal providers view most commonly during simulated PPV. DESIGN: Mixed methods study. Neonatal providers performed RFM-guided PPV on a neonatal manikin while wearing eye-tracking glasses to quantify visual attention on displayed RFM parameters (ie, exhaled tidal volume, flow, leak)...
June 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29898763/non-invasive-high-frequency-oscillatory-ventilation-versus-nasal-continuous-positive-airway-pressure-in-preterm-infants-with-respiratory-distress-syndrome-study-protocol-for-a-multi-center-prospective-randomized-controlled-trial
#4
Xing-Wang Zhu, Yuan Shi, Li-Ping Shi, Ling Liu, Jiang Xue, Rangasamy Ramanathan
BACKGROUND: Invasive mechanical ventilation (IMV) is associated with the development of adverse pulmonary and non-pulmonary outcomes in very premature infants. Various modes of non-invasive respiratory support are increasingly being used to decrease the incidence of bronchopulmonary dysplasia. The aim of this trial is to compare the effect of non-invasive high-frequency oscillatory ventilation (NHFOV) and nasal continuous positive airway pressure (NCPAP) in preterm infants with respiratory distress syndrome (RDS) as a primary non-invasive ventilation support mode...
June 14, 2018: Trials
https://www.readbyqxmd.com/read/29897161/pressure-ulcers-incidence-preventive-measures-and-risk-factors-in-neonatal-intensive-care-and-intermediate-care-units
#5
Pablo García-Molina, Evelin Balaguer-López, Francisco Pedro García-Fernández, María de Los Ángeles Ferrera-Fernández, José María Blasco, José Verdú
Epidemiological studies on pressure ulcers (PUs) in hospitalised infants are scarce. Spain lacks comprehensive research studies providing data on the prevalence or incidence in this population. This work was developed to determine the incidence of PUs in hospitalised infants admitted to intensive and intermediate care units, along with relevant risk factors and preventive measures. A prospective study appraising the incidence of PUs in infants was performed. The risk factors and preventive measures were evaluated using a multivariate logistic regression model...
June 13, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29895572/pulseless-electrical-activity-a-misdiagnosed-entity-during-asphyxia-in-newborn-infants
#6
Sparsh Patel, Po-Yin Cheung, Anne Lee Solevåg, Keith J Barrington, C Omar Farouk Kamlin, Peter G Davis, Georg M Schmölzer
BACKGROUND: The 2015 neonatal resuscitation guidelines added ECG as a recommended method of assessment of an infant's heart rate (HR) when determining the need for resuscitation at birth. However, a recent case report raised concerns about this technique in the delivery room. OBJECTIVES: To compare accuracy of ECG with auscultation to assess asystole in asphyxiated piglets. METHODS: Neonatal piglets had the right common carotid artery exposed and enclosed with a real-time ultrasonic flow probe and HR was continuously measured and recorded using ECG...
June 12, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29894475/neonatal-factors-related-to-center-variation-in-the-incidence-of-late-onset-circulatory-collapse-in-extremely-preterm-infants
#7
Yume Suzuki, Yumi Kono, Takahiro Hayakawa, Hironori Shimozawa, Miyuki Matano, Yukari Yada
BACKGROUND: Although late-onset circulatory collapse (LCC) is widely recognized in Japan, its etiology and the reason for center variation in its incidence remain unclear. This study's objectives were to identify the perinatal and neonatal factors related to LCC and to estimate the factors related to the center variation in the incidence of LCC. METHODS: Extremely preterm infants born between 2008 and 2012 who were registered in the database of the Neonatal Research Network, Japan were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29889001/the-mean-airway-pressure-may-be-the-answer
#8
Luis Perez-Baena, Martí Pons-Òdena
Altough the literature data and meta-analysis reported that NIV strategies, nasal intermittent positive pressure ventilation (N-IPPV) and Bi-level-NCPAP (BiPAP), has a better respiratory outcome than n-CPAP in neonatal respiratory distress syndrome, it is possible that the interpretation is not entirely accurate. Salvo et al. found that the incidence of NIV failure was significantly higher in the N-CPAP group versus N-SIPPV/BiPAP groups in infants with RDS. Nevertheless MAP was significantly higher in N-SIPPV group when compared to N-CPAP and BiPAP group (p < 0,05 in both) and MAP in the BiPAP group was significantly higher than N-CPAP group (p < 0,05)...
June 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29887608/early-diastolic-dysfunction-and-respiratory-morbidity-in-premature-infants-an-observational-study
#9
Neidin Bussmann, Colm Breatnach, Philip T Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash
OBJECTIVE: To test if diastolic dysfunction measured on day one of age is associated with the need for invasive ventilation in preterm infants. STUDY DESIGN: We conducted a retrospective observational tissue Doppler echocardiographic study over the first 12 h of age for infants born <32 weeks who were invasively ventilated, and infants on continuous positive pressure ventilation (CPAP). RESULTS: One hundred and eighty-three infants were included (27 ± 2 weeks and 999 ± 296 g)...
June 11, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29886760/estimating-risk-of-severe-neonatal-morbidity-in-preterm-births-under-32-weeks-of-gestation
#10
Emily F Hamilton, Alina Dyachenko, Antonio Ciampi, Kimberly Maurel, Philip A Warrick, Thomas J Garite
BACKGROUND: A large recent study analyzed the relationship between multiple factors and neonatal outcome and in preterm births. Study variables included reason for admission, indication for delivery, optimal steroid use, gestational age and other potentially prognostic factors. Using stepwise multivariable analysis, the only two variables independently associated with serious neonatal morbidity were gestational age and the presence of suspected intrauterine growth restriction as a reason for admission...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29886666/-techniques-and-experience-which-improve-the-surgical-outcomes-of-critical-and-complex-congenital-heart-disease-in-neonates
#11
Y Pan, B Jia
Objective: To discuss the experience of early surgical intervention to critical and complex congenital heart diseases (CHD) in neonates. Methods: A retrospective study of clinical records of patients with congenital heart diseases underwent surgical intervention in one single pediatric cardiac center was performed. From January 2009 to December 2017, 841 critical and complex CHD neonates were identified at Department of Cardiovascular Surgery, Children's Hospital of Fudan University, of which 6.5% were premature...
June 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29885776/early-energy-and-protein-intakes-and-associations-with-growth-bpd-and-rop-in-extremely-preterm-infants
#12
Susanna Klevebro, Vera Westin, Elisabeth Stoltz Sjöström, Mikael Norman, Magnus Domellöf, Anna-Karin Edstedt Bonamy, Boubou Hallberg
BACKGROUND & AIM: Extremely preterm infants face substantial neonatal morbidity. Nutrition is important to promote optimal growth and organ development in order to reduce late neonatal complications. The aim of this study was to examine the associations of early nutritional intakes on growth and risks of bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in a high-risk population. METHODS: This population-based cohort study includes infants born before 27 0/7 weeks of gestational age without severe malformations and surviving ≥10 days...
May 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29884681/home-extubation-in-a-neonate
#13
Prakash Loganathan, Judith Simpson, Paul Boutcher, Andrew Cooper, Allan Jackson, Rebecca J Benson
End-of-life care for many infants involves the withdrawal of mechanical ventilation. Usually this takes place in the hospital environment, but sometimes parents request that their infant dies at home. Facilitating this has significant practical and resource implications and raises both logistical and ethical questions. In this article, we report a neonatal case involving home extubation, explaining the processes involved as well as providing an ethical context.
June 8, 2018: Pediatrics
https://www.readbyqxmd.com/read/29883985/mode-of-delivery-in-previable-births
#14
Robert M Rossi, Emily A DeFranco
OBJECTIVE:  Preterm birth before 23 weeks of gestation typically results in neonatal death (5% survival). Society for Maternal-Fetal Medicine and American College of Obstetricians and Gynecologists published consensus guidelines recommending cesarean delivery (CD) not be performed for fetal indications between 20 and 226/7 weeks given the lack of proven benefit. We sought to quantify the previable CD rate and identify characteristics associated with previable CD. METHODS:  We performed a population-based retrospective cohort study of all live births in Ohio (2006-2015)...
June 8, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29870516/multicenter-study-of-device-associated-infection-rates-bacterial-resistance-length-of-stay-and-mortality-in-intensive-care-units-of-2-cities-of-vietnam-international-nosocomial-infection-control-consortium-findings
#15
Nguyen Viet Hung, Phan Thi Hang, Victor D Rosenthal, Le Thi Anh Thu, Le Thi Thu Nguyet, Ngo Quy Chau, Truong Anh Thu, Dinh Pham Phuong Anh, Tran Thi My Hanh, Tran Thi Thuy Hang, Dang Thi Van Trang, Nguyen Phuc Tien, Vo Thi Hong Thoa, Đao Quang Minh
OBJECTIVE: The aim of the study was to report the results of the International Nosocomial Infection Control Consortium (INICC) study conducted from May 2008 to March 2015. METHODS: A device-associated healthcare-acquired infection surveillance study in three adult intensive care units (ICUs) and 1 neonatal ICU from 4 hospitals in Vietnam using U.S. the Centers for Disease Control and Prevention's National Healthcare Safety Network (CDC/NHSN) definitions and criteria as well as INICC methods...
June 4, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29868821/sniffin-away-the-feeding-tube-the-influence-of-olfactory-stimulation-on-oral-food-intake-in-newborns-and-premature-infants
#16
Valentin A Schriever, Janine Gellrich, Nora Rochor, Ilona Croy, Helene Cao-Van, Mario Rüdiger, Thomas Hummel
Because of their immaturity many premature infants are fed via nasogastric tube. One objective of the neonatal care is to feed infants orally early. The olfactory function of premature infants is developed before birth and odorants have a significant impact on nutrition in infants. The aim of the study was to test whether odor stimulation has a positive effect on the transition from gavage to oral feeding in infants. Participants were premature infants with gestational age of more than 27 weeks, with full or partial gavage feeding, stable vital parameters and without invasive ventilation...
June 2, 2018: Chemical Senses
https://www.readbyqxmd.com/read/29867539/revisiting-the-role-of-trp-orai-and-asic-channels-in-the-pulmonary-arterial-response-to-hypoxia
#17
REVIEW
Roberto V Reyes, Sebastián Castillo-Galán, Ismael Hernandez, Emilio A Herrera, Germán Ebensperger, Aníbal J Llanos
The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they relax as arterial PO2 is re-established. The hypoxic pulmonary vasoconstriction (HPV) is intrinsic since it does not require neural or endocrine factors, as evidenced in isolated vessels. On the other hand, pulmonary arteries also respond to sustained hypoxia with structural and functional remodeling, involving growth of smooth muscle medial layer and later recruitment of adventitial fibroblasts, secreted mitogens from endothelium and changes in the response to vasoconstrictor and vasodilator stimuli...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29866238/amniotic-fluid-embolism
#18
Nadia Nawaz, Ahmed Raheem Buksh
Amniotic fluid embolism is a rare and severe problem in obstetric patients. We experienced a 21-year primigravida who underwent emergency cesarean section due to sudden collapse and fetal distress after rupture of membranes in labour. Subsequently, she developed intraoperative coagulopathy, hemorrhage, hypotension, and respiratory collapse requiring ventilation. Both maternal and neonatal lives were saved with full recovery and discharged in stable condition. The clinical diagnosis of amniotic fluid embolism (AFE) was made, which is a very rare complication of pregnancy/puerperium with varying presentation, ranging from cardiac arrest, circulatory collapse and death through mild degrees of organ system dysfunction with or without coagulopathy...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29863638/characteristics-risk-factors-and-outcomes-of-extracorporeal-membrane-oxygenation-use-in-pediatric-cardiac-icus-a-report-from-the-pediatric-cardiac-critical-care-consortium-registry
#19
Marissa A Brunetti, J William Gaynor, Lauren B Retzloff, Jessica L Lehrich, Mousumi Banerjee, Venugopal Amula, David Bailly, Darren Klugman, Josh Koch, Javier Lasa, Sara K Pasquali, Michael Gaies
OBJECTIVES: Cardiopulmonary failure in children with cardiac disease differs from the general pediatric critical care population, yet the epidemiology of extracorporeal membrane oxygenation support in cardiac ICUs has not been described. We aimed to characterize extracorporeal membrane oxygenation utilization and outcomes across surgical and medical patients in pediatric cardiac ICUs. DESIGN: Retrospective analysis of the Pediatric Cardiac Critical Care Consortium registry to describe extracorporeal membrane oxygenation frequency and outcomes...
June 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29852508/clinical-outcomes-among-diagnostic-subgroups-of-infants-with-severe-bronchopulmonary-dysplasia-through-2-years-of-age
#20
Gangaram Akangire, Winston Manimtim, Michael F Nyp, Janelle Noel-MacDonnell, Allyssa N Kays, William E Truog, Jane B Taylor
OBJECTIVE:  This article aimed to identify readmission risk factors through 2 years of life for infants with severe bronchopulmonary dysplasia (BPD) who do not require tracheostomy and ventilatory support after neonatal intensive care unit (NICU) discharge. It also aimed to identify if clinical differences exist between the subcategories of severe BPD. STUDY DESIGN:  A retrospective chart review was performed on 182 infants with severe BPD born between 2010 and 2015...
May 31, 2018: American Journal of Perinatology
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