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Pratibha Bhai, Sunita Bijarnia-Mahay, Ratna D Puri, Renu Saxena, Deepti Gupta, Udhaya Kotecha, Anil Sachdev, Dhiren Gupta, Vyomesh Vyas, Divya Agarwal, Vivek Jain, Rajeev K Bansal, Tapisha G Kumar, Ishwar Chander Verma
Fructose-1, 6-bisphosphatase deficiency is an autosomal recessive disorder of gluconeogenesis caused by genetic defect in the FBP1 gene. It is characterized by episodic, often life-threatening metabolic acidosis, liver dysfunction, and hyperlactatemia. Without a high index of suspicion, it may remain undiagnosed with devastating consequences. Accurate diagnosis can be achieved either by enzyme assay or gene studies. Enzyme assay requires a liver biopsy and is tedious, invasive, expensive, and not easily available...
May 18, 2018: Annals of Human Genetics
Anshul Aggarwal, Sunita Garhwal, Ajay Kumar
Objectives: One of the most important functions for a medical practitioner while treating a patient is to study the patient's complete medical history by going through all records, from test results to doctor's notes. With the increasing use of technology in medicine, these records are mostly digital, alleviating the problem of looking through a stack of papers, which are easily misplaced, but some of these are in an unstructured form. Large parts of clinical reports are in written text form and are tedious to use directly without appropriate pre-processing...
April 2018: Healthcare Informatics Research
Sunita Barik, Sushanta K Badamali, Sagarika Sahoo, Nandakishor Behera, Sudhir E Dapurkar
The present study is focussed on development of highly dispersed nanosize iron oxide (FexOy) particles within the uniform mesopore channels of SBA-3. Herein we report a comparative study between conventional incipient wetness and microwave assisted synthesis routes adopted to devise nanoparticles. The developed materials are characterised by following X-ray diffraction, high resolution transmission electron microscopy, proton induced X-ray emission, diffuse reflectance UV-visible spectroscopy, thermogravimetry and Fourier transform infrared spectroscopy...
January 1, 2018: Journal of Nanoscience and Nanotechnology
Ramnika Gumber, Jordana B Cohen, Matthew B Palmer, Sidney M Kobrin, Dan T Vogl, Alan G Wasserstein, Sunita D Nasta, Melissa B Bleicher, Roy D Bloom, Laura Dember, Adam Cohen, Brendan M Weiss, Jonathan J Hogan
The optimal treatment for the monoclonal gammopathies of renal significance is not known, but there is consensus among experts that treatment should be specific for the underlying clone. The majority of patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) do not have an identifiable clone, and prior studies have found poor renal outcomes for patients with PGNMID treated with a variety of regimens. Here we present a retrospective case series of 19 patients with PGNMID with a more uniform, clone-directed approach...
May 11, 2018: Kidney International
Ravi Shanker Verma, Sunita Ahlawat, Abha Uppal
We report the use of an optical guiding arrangement generated in a microfluidic channel to produce a stream of single cells in a line for single-cell Raman spectroscopic analysis. The optical guiding arrangement consisted of dual-line optical tweezers, generated using a 1064 nm laser, aligned in the shape of a '' symbol. By controlling the laser power in the tweezers and the flow rate in the microfluidic channel, a single line flow of cells could be produced in the tail of the guiding arrangement, where the 514...
May 14, 2018: Analyst
Radha Yadav, Suhail Hakeem Khan, Sanusi Bello Mada, Sunita Meena, Rajeev Kapila, Suman Kapila
There is a growing and alarming prevalence that increased serum cholesterol is closely related to increased cardiovascular disease risk. Probiotic consumption could be a safe and natural strategy to combat. Therefore, we sought to examine the cholesterol-lowering potential of co-supplementation of probiotic bacteria Lactobacillus fermentum MTCC: 5898-fermented buffalo milk (2.5% fat) in rats fed cholesterol-enriched diet. Male Wistar rats were divided into three groups on the basis of feed, viz. group 1, fed standard diet (SD); group 2, fed cholesterol-enriched diet (CED); and group 3, fed cholesterol-enriched diet along with L...
May 13, 2018: Probiotics and Antimicrobial Proteins
Scott V Wiener, Ling Chen, Alex R Shimotake, Misun Kang, Marshall L Stoller, Sunita P Ho
Purpose/Aim: The most common kidney stone composed of calcium oxalate forms on interstitial calcium phosphate mineral known as a Randall's plaque (RP). Due to limited information about events leading to the initial deposition of nanometer size interstitial calcium phosphate pre-clusters, there continues to be a debate on the initial site of calcium phosphate deposition and factors leading to stone formation. MATERIALS AND METHODS: High-resolution X-ray micro-computed tomography (CT), and light and electron microscopy techniques were used to characterize human renal pyramids and five representative kidney stones with identifiable stems...
December 2018: Connective Tissue Research
Michael Eaddy, Lucas Zullo, Sarah E Horton, Jennifer L Hughes, Betsy Kennard, Andrew Diederich, Graham J Emslie, Lisa Schuster, Sunita M Stewart
OBJECTIVE: Emotion dysregulation has been consistently linked to suicide ideation and attempt, but an explanatory model for this relationship has not been adequately investigated in adolescents. This study examined the concurrent relationship among emotion dysregulation, variables from the Interpersonal-Psychological Theory of Suicide (IPTS), and suicide risk (operationalized as a continuous variable that increases in intensity from nonspecific to active suicide ideation to suicide ideation with a plan) in a clinical adolescent sample...
May 10, 2018: Suicide & Life-threatening Behavior
Tanay Shah, Sunita Purohit, Mrudang Raval
No abstract text is available yet for this article.
May 9, 2018: Indian Journal of Pediatrics
Arun Goel, Balram Ji Omar, Rajesh Kathrotia, Prashant M Patil, Sunita Mittal
Context: Wholesale vegetable market is a rich source of generation of organic dust as loads of fruits and vegetables are loaded and unloaded here daily. Thus, regular workers are exposed to this organic dust for a considerable period of time depending on their work schedule. This study was planned to determine the microbial status of organic dust and to explore its association with pulmonary functions in the workers of wholesale vegetable market in Rishikesh. Materials and Methods: It was a cross-sectional exploratory/observational study...
January 2018: Indian Journal of Occupational and Environmental Medicine
Karen P Chu, Sarah P Baker, Julianna K Zenke, Ahmed Morad, Sunita Ghosh, Don Morrish, Sandy McEwan, David C Williams, Diane Severin, Todd Patrick William McMullen
BACKGROUND: The application of radioactive iodine in differentiated thyroid carcinomas has become more selective in an attempt to decrease morbidity. While ablative success has been documented, it is less clear how changes in radioactive iodine treatment strategies will influence long-term recurrence rates for patients with larger tumours and adverse pathological features including extrathyroidal extension and nodal metastases. METHODS: Patients diagnosed between 1995-2008 with differentiated thyroid carcinoma treated with thyroidectomy followed by radioactive iodine treatment were eligible...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
Sunita Vohra, Michael Schlegelmilch, Hsing Jou, Dawn Hartfield, Maria Mayan, Arto Ohinmaa, Bev Wilson, Maria Spavor, Paul Grundy
[This corrects the article DOI: 10.1016/j.conctc.2016.11.002.].
June 2017: Contemporary Clinical Trials Communications
Sunita Srivastava, Masafumi Fukuto, Oleg Gang
Stimuli-responsive 2D nanoscale systems offer intriguing opportunities for creating switchable interfaces. At liquid interfaces, such systems can provide control over interfacial energies, surface structure, and rheological and transport characteristics, which is relevant, for example, to bio- and chemical reactors, microfluidic devices, and soft robotics. Here, we explore the formation of a pH-responsive membrane formed from gold nanoparticles grafted with DNA (DNA-NPs) at a liquid-vapor interface. A DNA-NP 2D hexagonal lattice can be reversibly switched by pH modulation between an expanded state of non-connected nanoparticles at neutral pH and a contracted state of linked nanoparticles at acidic pH due to the AH+-H+A base pairing between A-motifs...
May 8, 2018: Soft Matter
Abhinandan Batra, Ann Harrington, Donovan J Lott, Rebecca Willcocks, Claudia Senesac, William McGehee, Dandan Xu, Sunita Mathur, Michael J Daniels, William D Rooney, Sean C Forbes, William Triplett, Jasjit K Deol, Ishu Arpan, Roxanne Bendixen, Richard Finkel, Erika Finanger, Gihan Tennekoon, Barry Byrne, Barry Russman, Lee H Sweeney, Glenn Walter, Krista Vandenborne
OBJECTIVE: The main objective of this study were to examine the effect of disease on strength in two functionally important lower limb muscles over a period of two-years in children with Duchene Muscular Dystrophy (DMD). DESIGN: Seventy-Seven DMD children participated in this study. Plantar flexors (PF), knee extensors (KE) strength and performance on timed tests (Six-min walk, 4-stairs, 10m-walk, supine-up) was assessed yearly over two-years. Multivariate normal regression was used to assess changes in strength over time in the DMD group...
May 2, 2018: American Journal of Physical Medicine & Rehabilitation
Sunita R Jha, Julee McDonagh, Ros Prichard, Phillip J Newton, Louise D Hickman, Erik Fung, Peter S Macdonald, Caleb Ferguson
OBJECTIVES: The objectives of this short report are to: (i) explore #Frailty Twitter activity over a six-month period; and (ii) provide a snapshot Twitter content analysis of #Frailty usage. METHODS: A mixed-method study was conducted to explore Twitter data related to frailty. The primary search term was #Frailty. Objective 1: data were collected using Symplur analytics, including variables for total number of tweets, unique tweeters (users) and total number of impressions...
May 7, 2018: Australasian Journal on Ageing
Mackenzie Sward, Clayton Kirk, Sunita Kumar, Nabila Nasir, William Adams, Charles Bouchard
No abstract text is available yet for this article.
May 2, 2018: Ocular Surface
Arthur Lui, Karen Mulder, Christine Brezden-Masley, Michael Vickers, Jose Monzon, Hagen Kennecke, Rakesh Goel, Larissa Vos, Sunita Ghosh, Horia Marginean, Anthony Fields, Jean Maroun, Jennifer Spratlin
Purpose Chemotherapy remains the primary treatment for metastatic gastric/GEJ cancer but optimal agents and schedule remain controversial. This study examined the safety and efficacy of first-line Irinotecan, capecitabine (Xeloda®), and Oxaliplatin (IXO). Patients and Methods Eligible patients with HER2-unamplified/unknown, metastatic gastric/GEJ adenocarcinoma were treated with 21-day cycle IXO at dose level 1 (DL1: Day 1 O-100 mg/m2 & I-160 mg/m2 IV, Day 2-15 X-1900 mg/m2 /day PO divided doses) or modified IXO (mIXO): Day 1 O-85 mg/m2 & I-120 mg/m2 IV, Day 2-15 X-1425 mg/m2 /day PO divided doses)...
May 4, 2018: Investigational New Drugs
Sunita Vs Bandewar, Leni Chaudhuri, Lubna Duggal, Sanjay Nagral
On Friday, March 9, 2018 the five-judge Constitution Bench (CB) of the Supreme Court of India (SCI) chaired by Dipak Misra, the Chief Justice of India, pronounced its judgment (1) (henceforth CC judgment) granting, for the first time in India, legal recognition to "advanced medical directives" or "living wills", ie, a person's decision communicated in advance on withdrawal of life-saving treatment under certain conditions, which should be respected by the treating doctor/s and the hospital...
April 2018: Indian Journal of Medical Ethics
Bihong T Chen, Sean K Sethi, Taihao Jin, Sunita K Patel, Ningrong Ye, Can-Lan Sun, Russell C Rockne, E Mark Haacke, James C Root, Andrew J Saykin, Tim A Ahles, Andrei I Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, George Somlo, Daneng Li, Richard Yang, Heidi Tan, Vani Katheria, Rachel Morrison, Arti Hurria
BACKGROUND: Cognitive decline is among the most feared treatment-related outcomes of older adults with cancer. The majority of older patients with breast cancer self-report cognitive problems during and after chemotherapy. Prior neuroimaging research has been performed mostly in younger patients with cancer. The purpose of this study was to evaluate longitudinal changes in brain volumes and cognition in older women with breast cancer receiving adjuvant chemotherapy. METHODS: Women aged ≥ 60 years with stage I-III breast cancer receiving adjuvant chemotherapy and age-matched and sex-matched healthy controls were enrolled...
May 2, 2018: Breast Cancer Research: BCR
Asmita Ghimire, Meeta Singh, Kesang Dikki Bista, Neebha Ojha, Sunita Bajracharya, Neeta Katuwal
Ovarian vein thrombosis is one of the rare causes for acute abdomen. Occult presentation of this disease may lead to diagnostic dilemma. A sixteen years female who was operated as a case of ectopic pregnancy was finally diagnosed as having ovarian vein thrombosis. She was successfully treated with anticoagulant.
March 13, 2018: Journal of Nepal Health Research Council
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