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Karmon E Helmle, Sunita Chacko, Trevor Chan, Alison Drake, Alun L Edwards, Glenda E Moore, Leta C Philp, Naomi Popeski, Rhonda L Roedler, Edwin J R Rogers, Gabrielle L Zimmermann, Julie McKeen
OBJECTIVES: To develop and evaluate a Basal Bolus Insulin Therapy (BBIT) Knowledge Translation toolkit to address barriers to adoption of established best practice with BBIT in the care of adult inpatients. METHODS: This study was conducted in 2 phases and focused on the hospitalist provider group across 4 acute care facilities in Calgary. Phase 1 involved a qualitative evaluation of provider and site specific barriers and facilitators, which were mapped to validated interventions using behaviour change theory...
December 27, 2017: Canadian Journal of Diabetes
Matthew J Resnick, Amy J Graves, Sunita Thapa, Robert Gambrel, Mark D Tyson, Daniel Lee, Melinda B Buntin, David F Penson
Importance: Despite rapid diffusion of Accountable Care Organizations (ACOs), whether ACO enrollment results in observable changes in cancer screening remains unknown. Objective: To determine whether Medicare Shared Savings Program (MSSP) ACO enrollment changes the appropriateness of screening for breast, colorectal, and prostate cancers. Design, Setting, and Participants: For this population-based analysis of Medicare beneficiaries, we used Medicare data from 2007 through 2014 and evaluated changes in screening associated with ACO enrollment using differences-in-differences (DD) analyses...
March 19, 2018: JAMA Internal Medicine
Saahir Khan, Audrey Nakasone, Minoo Ghajar, Mariam Zhowandai, Sunita Prabhu, Rick Alexander, Julie Low, Ellena Peterson, Lauri Thrupp
For 94 patients with culture-positive pulmonary tuberculosis, time-to-detection (TTD), acid-fast bacilli (AFB) smear, and nucleic acid amplification test (NAAT) results were reviewed. All 12 patients whose first specimen was negative by AFB smear and NAAT had prolonged TTD, indicating low transmissibility and supporting discontinuing isolation for low-risk patients. Infect Control Hosp Epidemiol 2018;1-3.
March 19, 2018: Infection Control and Hospital Epidemiology
Deepti Singh, Shwetha Narayanamoorthy, Sunita Gamre, Ananda Guha Majumdar, Manish Goswami, Umesh Gami, Susan Cherian, Mahesh Subramanian
Antibiotic resistance is a global problem and there is an urgent need to augment the arsenal against pathogenic bacteria. The emergence of different drug resistant bacteria is threatening human lives to be pushed towards the pre-antibiotic era. Botanical sources remain a vital source of diverse organic molecules that possess antibacterial property as well as augment existing antibacterial molecules. Piper betle, a climber, is widely used in south and south-east Asia whose leaves and nuts are consumed regularly...
March 14, 2018: Free Radical Biology & Medicine
Sunita Simon Kurpad
It is important for health professionals to have an ethical framework to help take decisions regarding psychosocial interventions in patients with addictive disorders. As patients with addictive disorders are vulnerable to unethical actions in the name of treatment, therapists need to aware of their role in delivering ethical care - not just in their own clinical practice but in the setting in which they deliver the interventions. This article aims to sensitize the health professional to the various arenas in which ethical challenges may arise...
February 2018: Indian Journal of Psychiatry
Visesato Mor, Antonella Rella, Amir M Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B Desai, Nathan P Wiederhold, Annette W Fothergill, William R Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L Rodrigues, Chiara Luberto, Leonardo Nimrichter, Maurizio Del Poeta
No abstract text is available yet for this article.
March 13, 2018: MBio
Sara Nejatinamini, Catherine Kubrak, Mirey Álvarez-Camacho, Vickie E Baracos, Sunita Ghosh, Wendy V Wismer, Vera C Mazurak
This study assessed dietary and micronutrient intakes of head and neck cancer (HNC) patients at key points in the disease trajectory and evaluated the contribution of oral nutritional supplements (ONS) to micronutrient intake. HNC patients (n = 114) completed a three-day dietary record and a tool to assess Nutrition Impact Scores (NIS) at baseline, post-treatment, and follow-up. Foods were classified into food categories. Micronutrient, protein, and energy intakes were compared to European Society for Parenteral and Enteral Nutrition guidelines for cancer patients...
March 13, 2018: Nutrition and Cancer
Charu C Garg, Sarmila Mazumder, Sunita Taneja, Medha Shekhar, Sanjana Brahmawar Mohan, Anuradha Bose, Sharad D Iyengar, Rajiv Bahl, Jose Martines, Nita Bhandari
Trial design: Three feeding regimens-centrally produced ready-to-use therapeutic food, locally produced ready-to-use therapeutic food, and augmented, energy-dense, home-prepared food-were provided in a community setting for children with severe acute malnutrition (SAM) in the age group of 6-59 months in an individually randomised multicentre trial that enrolled 906 children. Foods, counselling, feeding support and treatment for mild illnesses were provided until recovery or 16 weeks. Methods: Costs were estimated for 371 children enrolled in Delhi in a semiurban location after active survey and identification, enrolment, diagnosis and treatment for mild illnesses, and finally treatment with one of the three regimens, both under the research and government setting...
2018: BMJ Global Health
Tom Williamson, Scott Everitt, Sunita Chauhan
BACKGROUND: High intensity focused ultrasound (HIFU) represents a non-invasive method for the destruction of cancerous tissue within the body. Heating of targeted tissue by focused ultrasound transducers results in the creation of ellipsoidal lesions at the target site, the locations of which can have a significant impact on treatment outcomes. Towards this end, this work describes a method for the optimization of lesion positions within arbitrary tumors, with specific anatomical constraints...
February 26, 2018: Computers in Biology and Medicine
Ashwini Dolle, Narasimhappagari Jagadeesh, Suman Bhaumik, Sunita Prakash, Himansu S Biswal, Konkallu Hanumae Gowd
RATIONALE: The modes of cleavages of lanthionine/methyllanthionine bridges under electron transfer dissociation (ETD) was investigated using synthetic and natural lantipeptides. Knowledge on the mass spectrometric fragmentation of lanthionine/methyllanthionine bridges may assist in the development of analytical methods for rapid discovery of new lantibiotics. Present study strengthens the advantage of ETD in the characterization of posttranslational modifications of peptides and proteins...
March 8, 2018: Rapid Communications in Mass Spectrometry: RCM
Sarmila Mazumder, Ravi Prakash Upadhyay, Zelee Hill, Sunita Taneja, Brinda Dube, Jasmine Kaur, Medha Shekhar, Runa Ghosh, Shruti Bisht, Jose Carlos Martines, Rajiv Bahl, Halvor Sommerfelt, Nita Bhandari
BACKGROUND: Low and middle income countries (LMICs), including India, contribute to a major proportion of low birth weight (LBW) infants globally. These infants require special care. Kangaroo Mother Care (KMC) in hospitals is a cost effective and efficacious intervention. In institutional deliveries, the duration of facility stay is often short. In LMICs, a substantial proportion of deliveries still occur at home and access to health care services is limited. In these circumstances, a pragmatic choice may be to initiate KMC at home for LBW babies...
March 2, 2018: BMC Public Health
Parag Bharadwaj, Brynn E Sheehan, Sunita Dodani, Charles F von Gunten
There continue to be great variations in the management of pain in palliative care. Efforts need to be made within the field develop strategies to address this to avoid undue distress in patients.
2018: Palliative Care
Vikas Vilas Pakhare, Chinmay Harishchandra Khandait, Sunita Satish Shrivastav, Prasad Vijayrao Dhadse, Vidya Sudhindhra Baliga, Vasudevan Dwarkanathan Seegavadi
Periodontally accelerated osteogenic orthodontic procedure has become useful adjunct to reduce orthodontic treatment time as compared with conventional orthodontics. This case demonstrates the use of Piezosurgery® to facilitate rapid tooth movement with relatively shorter treatment time. A 23-year-old male with Angles Class I malocclusion having spaced anterior teeth and protrusion requested orthodontic treatment with reduced time period. Before surgery, presurgical orthodontic treatment was done to do initial alignment of the teeth...
September 2017: Journal of Indian Society of Periodontology
Amitha Kalaichandran, Nick Barrowman, Jason Chan, Karine Toupin-April, Sunita Vohra, Roger Zemek
OBJECTIVE: This study aimed to determine the prevalence of complementary health approaches (CHAs) specifically for acute complaints in patients assessed in a pediatric emergency department (ED) and factors associated with use. METHODS: A cross-sectional survey was offered to patients between the age of 28 days and 18 years assessed at a tertiary pediatric ED between December 2014 and July 2015. Univariate and multivariate logistic regressions were used to identify variables associated with CHA use...
February 28, 2018: Pediatric Emergency Care
Pearlin, Sunita Nayak, Geetha Manivasagam, Dwaipayan Sen
PURPOSE OF REVIEW: To conduct a thorough appraisal of recent and inventive advances in the field of bone tissue engineering using biomaterials, cell-based research, along with the incorporation of biomimetic properties using surface modification of scaffolds. RECENT FINDINGS: This paper will provide an overview on different biomaterials and emerging techniques involved in the fabrication of scaffolds, brief description of signaling pathways involved in osteogenesis, and the effect of surface modification on the fate of progenitor cells...
February 27, 2018: Current Osteoporosis Reports
Anthea C Peters, Michael S Akinwumi, Carlos Cervera, Curtis Mabilangan, Sunita Ghosh, Raymond Lai, Marco Iafollo, Karen Doucette, Jutta K Preiksaitis
BACKGROUND: Posttransplant lymphoproliferative disorders (PTLD) are a complication of solid organ transplantation (SOT) associated with Epstein-Barr virus (EBV). METHODS: We analyzed the incidence of and risk factors for PTLD among adult SOT recipients at our center over 30 years (1984-2013). We also compared PTLD incidence before and after a prevention strategy of EBV viral load monitoring in EBV serology mismatched patients was adopted in 2001 (ie transplant era 1 (1983-2001) vs era 2 (2002-13))...
February 26, 2018: Transplantation
Sunita Radhakrishnan, Philip P Chen, Anna K Junk, Kouros Nouri-Mahdavi, Teresa C Chen
PURPOSE: To examine the efficacy and complications of laser peripheral iridotomy (LPI) in subjects with primary angle closure (PAC). METHODS: Literature searches in the PubMed and Cochrane databases were last conducted in August 2017 and yielded 300 unique citations. Of these, 36 met the inclusion criteria and were rated according to the strength of evidence; 6 articles were rated level I, 11 articles were rated level II, and 19 articles were rated level III. RESULTS: Reported outcomes were change in angle width, effect on intraocular pressure (IOP) control, disease progression, and complications...
February 23, 2018: Ophthalmology
Amitha Kalaichandran, Nick Barrowman, Jason Chan, Karine Toupin-April, Sunita Vohra, Roger Zemek
Background and Objectives: Up to one-half of children may use complementary health approaches (CHA). However, current prevalence in North America, variables associated with CHA use and caregiver perceptions of effectiveness are unclear. We aimed to determine the self-reported use of CHA during the previous 12 months in paediatric patients, demographic variables associated with CHA use and perceptions around effectiveness of CHA. Methods: A cross-sectional survey study of patients aged between 28 days and 18 years who presented to a large paediatric emergency department was conducted between December 2014 and July 2015...
February 2018: Paediatrics & Child Health
Guy Helman, Sunita Venkateswaran, Adeline Vanderver
Unique clinical presentations and magnetic resonance imaging patterns can help differentiate the various adult presentations of leukodystrophies and leukoencephalopathies. White-matter disorders are genetically based disorders affecting the central nervous system white matter, with or without peripheral nervous system involvement. These disorders predominantly affect patients in the pediatric population; however, a number of classic leukodystrophies can present in adulthood. Disease progression can be of variable onset with a broad range of symptoms, usually progressing from cognitive dysfunction...
2018: Handbook of Clinical Neurology
Brita Askeland Winje, Ingrid Kvestad, Srinivasan Krishnamachari, Karim Manji, Sunita Taneja, David C Bellinger, Nita Bhandari, Shruti Bisht, Anne Marie Darling, Christopher P Duggan, Wafaie Fawzi, Mari Hysing, Tivendra Kumar, Anura V Kurpad, Christopher R Sudfeld, Erling Svensen, Susan Thomas, Tor A Strand
INTRODUCTION: As many as 250 million children under the age of 5 may not be reaching their full developmental potential partly due to poor nutrition during pregnancy and the first 2 years of life. Micronutrients, including vitamin B12 , are important for the development of brain structure and function; however, the timing, duration and severity of deficiencies may alter the impact on functional development outcomes. Consequently, to fully explore the effect of vitamin B12 on cognitive function, it is crucial to measure neurodevelopment at different ages, in different populations and with vitamin B12 supplementation at different times during the critical periods of neurodevelopment...
February 22, 2018: BMJ Open
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