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https://www.readbyqxmd.com/read/28933962/tool-to-assess-causality-of-direct-and-indirect-adverse-events-associated-with-therapeutic-interventions
#1
Liliane Zorzela, Silvano Mior, Heather Boon, Anita Gross, Jeromy Yager, Rose Carter, Sunita Vohra
OBJECTIVE: To develop and test a tool to assess causality of direct and indirect adverse events associated with therapeutic interventions. The intervention was one or more drugs and/or natural health products, a device, or practice (professional delivering the intervention). METHODS: Through the assessment of causality of adverse events, we can learn about factors contributing to the harm and consider what modification may prevent its reoccurrence. Existing scales (WHO-UMC, Naranjo and Horn) were adapted to develop a tool (algorithm and table) to evaluate cases of serious harmful events reported through a national surveillance study...
September 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28930559/histone-deacetylase-a-potential-therapeutic-target-for-ovarian-dysfunction
#2
Sunita Sunita, Pankaj Kumar Singh, Suneel Kumar Onteru, Dheer Singh
Post-partum uterine disorders and reproductive tract infections cause ovarian dysfunction and infertility. Histone deacetylases (HDACs) prevent the relaxation of chromatin, and positively or negatively regulate transcription. Hence, HDACs play a pivotal role in altering the gene expression that impact different signalling pathways underling ovarian dysfunction. Thus, HDAC inhibitors (HDACi) may act as potential therapeutic targets in the treatment of an array of disorders impacting ovarian function.
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929079/spontaneous-recurrent-csf-rhinorrhoea-a-rare-case-and-review-of-literature
#3
Nishit Shah, C E Deopujari, Sunita Chhapola Shukla
Cerebrospinal fluid (CSF) rhinorrhoea is the leakage of CSF through the communication between the subarachnoid space and the nasal cavity. Surgical repair is indicated in all cases of spontaneous leaks, recurrent leaks, leaks that do not stop after conservative management and cases with history of meningitis. We present a rare case of spontaneous (delayed onset post traumatic) CSF rhinorrhoea with multiple defect sites, which was treated with an endonasal endoscopic repair. The patient was asymptomatic for 9 years after surgery, and then presented with a spontaneous left frontal recess CSF leak, which was closed using endonasal approach...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28929067/per-operative-study-of-relation-of-zuckerkandl-tubercle-with-recurrent-laryngeal-nerve-in-thyroid-surgery
#4
Priyanka Singh, Kalpana Sharma, Sunita Agarwal
To identify Zuckerkandl tubercle and to determine relationship between the recurrent laryngeal nerve and Zuckerkandl tubercle (ZT). Peroperative study. Intraoperatively Zuckerkandl tubercle was identified. Size of the thyroid lobe and Zuckerkandl tubercle were co-related and direction of tubercle in relation to recurrent laryngeal nerve was examined. Grading of tubercle on the basis of size was done. We studied its direction and relation with recurrent laryngeal nerve. ZT was identified in 87.86% (179 out of 206) of cases...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28926296/randomised-controlled-trial-of-urokinase-versus-placebo-for-non-draining-malignant-pleural-effusion
#5
Eleanor K Mishra, Amelia O Clive, Genevieve H Wills, Helen E Davies, Andrew E Stanton, Mohamed Al-Aloul, Alan Hart-Thomas, Justin Pepperell, Matthew Evison, Tarek Saba, Richard Neil Harrison, Anur Guhan, Matthew E Callister, Ramamurthy Sathyamurthy, Sunita Rehal, John P Corcoran, Robert Hallifax, Ioannis Psallidas, Nicky Russell, Rachel Shaw, Melissa Dobson, John M Wrightson, Alex West, Y C Gary Lee, Andrew J Nunn, Robert F Miller, Nick A Maskell, Najib M Rahman
RATIONALE: Patients with malignant pleural effusion (MPE) experience breathlessness, which is treated by drainage and pleurodesis. Incomplete drainage results in residual dyspnea and pleurodesis failure. Intrapleural fibrinolytics lyse septations within pleural fluid, improving drainage. OBJECTIVES: To assess the effects of intrapleural urokinase on dyspnea and pleurodesis success in patients with non-draining malignant effusion. METHODS: Prospective double blind randomised trial; patients with non-draining effusion were randomly allocated 1:1 to intrapleural urokinase (100,000 IU three doses 12 hourly) or matched placebo...
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28923060/vitamin-d-status-and-neurodevelopment-and-growth-in-young-north-indian-children-a-secondary-data-analysis
#6
Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Ingrid Kvestad, Tor A Strand, Maharaj Kishan Bhan
BACKGROUND: Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng/ml) is associated with neurodevelopment and physical growth in young children. METHODS: We used data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in children aged 6 to 30 months conducted in Delhi, India...
September 18, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28919901/introgression-of-shoot-fly-atherigona-soccata-l-moench-resistance-qtls-into-elite-post-rainy-season-sorghum-varieties-using-marker-assisted-backcrossing-mabc
#7
Sunita Gorthy, Lakshmi Narasu, Anil Gaddameedi, Hari C Sharma, Anuradha Kotla, Santosh P Deshpande, Ashok K Are
Shoot fly (Atherigona soccata L. Moench) is a serious pest in sorghum production. Management of shoot fly using insecticides is expensive and environmentally un-safe. Developing host-plant resistance is the best method to manage shoot fly infestation. Number of component traits contribute for imparting shoot fly resistance in sorghum and molecular markers have been reported which were closely linked to QTLs controlling these component traits. In this study, three QTLs associated with shoot fly resistance were introgressed into elite cultivars Parbhani Moti (= SPV1411) and ICSB29004 using marker assisted backcrossing (MABC)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28916183/cancer-related-cognitive-changes
#8
Arash Asher, Kathleen Van Dyk, Sunita K Patel, Robin Newman, Jessica Engle, Nancy Hutchinson, Lynne Padgett
No abstract text is available yet for this article.
September 12, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28904116/integrated-interventions-delivered-in-health-systems-home-and-community-have-the-highest-impact-on-breastfeeding-outcomes-in-low-and-middle-income-countries
#9
REVIEW
Bireshwar Sinha, Ranadip Chowdhury, Ravi Prakash Upadhyay, Sunita Taneja, Jose Martines, Rajiv Bahl, Mari Jeeva Sankar
Background: Improving breastfeeding rates is critical. In low- and middle-income countries (LMICs), only subtle improvements in breastfeeding rates have been observed over the past decade, which highlights the need for accelerating breastfeeding promotion interventions.Objectives: The objective of this article is to update evidence on the effect of interventions on early initiation of and exclusive (<1 and 1-5 mo) and continued (6-23 mo) breastfeeding rates in LMICs when delivered in health systems, in the home or in community environments, or in a combination of settings...
September 13, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28903741/is-economic-dependence-on-the-husband-a-risk-factor-for-intimate-partner-violence-against-female-factory-workers-in-nepal
#10
Sunita Dhungel, Pabita Dhungel, Shalik Ram Dhital, Christiane Stock
BACKGROUND: Violence related injury is a serious public health issue all over the world. This study aims to assess the association between several socio-economic factors and intimate partner violence (IPV) in Nepal. METHODS: A cross-sectional study was conducted among 236 women working in carpet and garment factories in Kathmandu, Nepal. Interviews were conducted to collect quantitative data on three forms of IPV, namely physical violence, psychological violence and sexual violence, as well as on a number of potentially associated factors...
September 13, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28900808/aerial-application-of-copper-for-dothistroma-control-in-new-zealand-s-planted-forests-effect-on-stream-environments
#11
Brenda R Baillie, Anthony W Evanson, Diana Unsworth, Sunita Jeram
Limited information is available on the risk to aquatic environments from the aerial application of copper fungicides to treat dothistroma needle blight in managed forests. Cuprous oxide was aerially applied to three catchments of Pinus radiata of varying age classes in the central North Island of New Zealand. Copper was monitored in stream water and sediments prior to and for 1 month after application. Copper deposits collected from tracer plates deployed above the water surface along the stream channels within the treated areas at each site ranged from 13 to 406 ppm...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28899949/the-future-genetics-advances-in-men1-therapeutic-approaches-and-management-strategies
#12
REVIEW
Sunita K Agarwal
The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has shown that germline heterozygous mutations in the MEN1 gene located on chromosome 11q13 predisposes to the development of tumors in the MEN1 syndrome. Tumor development occurs upon loss of the remaining normal copy of the MEN1 gene in MEN1-target tissues. Therefore, MEN1 is a classic tumor suppressor gene in the context of MEN1. This tumor suppressor role of the protein encoded by the MEN1 gene, menin, holds true in mouse models with germline heterozygous Men1 loss, wherein MEN1-associated tumors develop in adult mice after spontaneous loss of the remaining non-targeted copy of the Men1 gene...
October 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28893216/antimalarial-efficacy-of-pongamia-pinnata-l-pierre-against-plasmodium-falciparum-3d7-strain-and-plasmodium-berghei-anka
#13
P V V Satish, K Sunita
BACKGROUND: The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cytotoxicity against Brine shrimp larvae and THP-1 cell line. For in vivo study, the plant extract which has shown potent in vitro antimalarial activity was tested against Plasmodium berghei (ANKA strain). METHODS: The plant Pongamia pinnata was collected from the herbal garden of Acharya Nagarjuna University of Guntur district, Andhra Pradesh, India...
September 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28892884/effect-of-metaboreflex-on-cardiovascular-system-in-subjects-of-metabolic-syndrome
#14
Pramita Dubey, Sunita Tiwari, Manish Bajpai, Kalpana Singh, Praveen Jha
INTRODUCTION: Metaboreflex is a reflex in which muscle receptors send signals regarding metabolic (metabolites accumulation like lactic acid, potassium, adenosine) conditions of the muscles to nucleus tractus solitarius via afferent III and IV fibres to cause haemodynamic adjustments in order to regulate blood flow on the basis of the status of contracting muscle. Dysregulation in its mechanism in metabolic syndrome is demonstrated. AIM: To study the effect of metaboreflex by both isometric and rhythmic handgrip exercise on CVS parameters {Blood Pressure (BP), Cardiac Output (CO) and Systemic Vascular Resistance (SVR)} in subjects of metabolic syndrome...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891105/regioselective-transformation-of-long-%C3%AF-conjugated-backbones-from-oligofurans-to-oligoarenes
#15
Sunita Gadakh, Linda J W Shimon, Ori Gidron
We demonstrate the transformation of oligofurans via sequential Diels-Alder cycloaddition to obtain oligoarenes in 2 chemical steps, regardless of the oligomer length. Using this method, oligonaphthalenes containing up to six units and involving the formation of up to 12 new C-C bonds were obtained with high yield. The versatility of this method was demonstrated for various polyaromatic hydrocarbons. The regioselectivity of this process allows the synthesis of a library of substituted triarylenes from single terfuran precursor, via modification of dienophile strength and order of addition...
September 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28888116/comprehensive-review-on-toxicity-of-persistent-organic-pollutants-from-petroleum-refinery-waste-and-their-degradation-by-microorganisms
#16
Sunita J Varjani, Edgard Gnansounou, Ashok Pandey
Control and prevention of environmental pollution has become a worldwide issue of concern. Aromatic hydrocarbons including benzene, toluene, ethyl benzene, xylene (BTEX) and polyaromatic hydrocarbons (PAHs) are persistent organic pollutants (POPs), released into the environment mainly by exploration activities of petroleum industry. These pollutants are mutagenic, carcinogenic, immunotoxic and teratogenic to lower and higher forms of life i.e. microorganisms to humans. According to the International Agency for Research on Cancer (IARC) and United States Environmental Protection Agency (U...
September 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28884603/folic-acid-in-pregnancy-and-childhood-asthma-a-us-cohort
#17
Michelle K Trivedi, Sunita Sharma, Sheryl L Rifas-Shiman, Carlos A Camargo, Scott T Weiss, Emily Oken, Matthew W Gillman, Diane R Gold, Dawn L DeMeo, Augusto A Litonjua
Prenatal folic acid exposure has been linked to higher risk of childhood asthma in countries that do not fortify the food supply with folic acid. This study seeks to examine this association in the United States, where the food supply is generally fortified with folic acid. Participants were 1279 mother-child pairs from Project Viva, an ongoing prospective birth cohort, with folic acid intake in pregnancy assessed through validated food frequency questionnaires. The primary outcome was physician-diagnosed asthma at mid-childhood...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28879447/lactic-acid-bacteria-isolated-from-yak-milk-show-probiotic-potential
#18
Manpreet Kaur, Harjodh Singh, Manoj Jangra, Lakhwinder Kaur, Pallavi Jaswal, Chetna Dureja, Hemraj Nandanwar, Saumya Ray Chaudhuri, Manoj Raje, Sunita Mishra, Anil Kumar Pinnaka
Probiotic industries strive for new, efficient and promising probiotic strains that impart a positive impact on consumer health. Challenges are persisting in isolation, screening, and selection of the new indigenous probiotic strains. In the present research, we explored the probiotic potential of 17 lactic acid bacteria isolated from Yak milk in a series of in vitro tests. We also demonstrated their health benefits, i.e., cholesterol degradation, lactose digestion, antimicrobial activity, antioxidant, and anticancer activities...
September 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28866768/providers-response-to-clinical-decision-support-for-qt-prolonging-drugs
#19
Sunita Sharma, J Martijn Bos, Robert F Tarrell, Gyorgy J Simon, Bruce W Morlan, Michael J Ackerman, Pedro J Caraballo
Commonly used drugs in hospital setting can cause QT prolongation and trigger life-threatening arrhythmias. We evaluate changes in prescribing behavior after the implementation of a clinical decision support system to prevent the use of QT prolonging medications in the hospital setting. We conducted a quasi-experimental study, before and after the implementation of a clinical decision support system integrated in the electronic medical record (QT-alert system). This system detects patients at risk of significant QT prolongation (QTc>500ms) and alerts providers ordering QT prolonging drugs...
September 2, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28865259/current-margin-practice-and-effect-on-re-excision-rates-following-the-publication-of-the-sso-astro-consensus-and-abs-consensus-guidelines-a-national-prospective-study-of-2858-women-undergoing-breast-conserving-therapy-in-the-uk-and-ireland
#20
Sarah Shuk-Kay Tang, Sarantos Kaptanis, James B Haddow, Giuseppina Mondani, Beatrix Elsberger, Marios Konstantinos Tasoulis, Christine Obondo, Neil Johns, Wisam Ismail, Asim Syed, Panayioti Kissias, Mary Venn, Souganthy Sundaramoorthy, Gareth Irwin, Amtul S Sami, Dalia Elfadl, Alice Baggaley, Dionysios Dennis Remoundos, Fiona Langlands, Petros Charalampoudis, Zoe Barber, Werbena L S Hamilton-Burke, Ayesha Khan, Chiara Sirianni, Louise Anne-Marie Grant Merker, Sunita Saha, Risha Arun Lane, Sharat Chopra, Sophie Dupré, Aiden T Manning, Edward R St John, Aya Musbahi, Nokwanda Dlamini, Caitlin L McArdle, Chloe Wright, James O Murphy, Ravi Aggarwal, Matei Dordea, Karen Bosch, Donna Egbeare, Hisham Osman, Salim Tayeh, Faraz Razi, Javeria Iqbal, Serena F C Ledwidge, Vanessa Albert
INTRODUCTION: There is variation in margin policy for breast conserving therapy (BCT) in the UK and Ireland. In response to the Society of Surgical Oncology and American Society for Radiation Oncology (SSO-ASTRO) margin consensus ('no ink on tumour' for invasive and 2 mm for ductal carcinoma in situ [DCIS]) and the Association of Breast Surgery (ABS) consensus (1 mm for invasive and DCIS), we report on current margin practice and unit infrastructure in the UK and Ireland and describe how these factors impact on re-excision rates...
August 29, 2017: European Journal of Cancer
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