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https://www.readbyqxmd.com/read/28644549/a-retrospective-analysis-of-the-symptoms-and-course-of-dengue-infection-during-pregnancy
#1
Kavita Agarwal, Sunita Malik, Pratima Mittal
OBJECTIVE: To assess outcomes among pregnant women diagnosed with dengue infection. METHODS: In a retrospective study, the medical records of all pregnant women with dengue infection admitted to Safdarjung Hospital, New Delhi, India, from July to December 2015 were reviewed. Maternal and fetal outcomes were compared by pregnancy length and stage of disease at diagnosis. RESULTS: Overall, 62 pregnant women with dengue infection were identified...
June 23, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28642546/slc4a11-depletion-impairs-nrf2-mediated-antioxidant-signaling-and-increases-reactive-oxygen-species-in-human-corneal-endothelial-cells-during-oxidative-stress
#2
Sanjukta Guha, Sunita Chaurasia, Charanya Ramachandran, Sanhita Roy
Corneal endothelial dystrophy is a progressive disease with gradual loss of vision and characterized by degeneration and dysfunction of corneal endothelial cells. Mutations in SLC4A11, a Na(+) dependent OH(-) transporter, cause congenital hereditary endothelial dystrophy (CHED) and Fuchs' endothelial corneal dystrophy (FECD), the two most common forms of endothelial degeneration. Along with genetic factors, oxidative stress plays a role in pathogenesis of several corneal diseases. In this study we looked into the role of SLC4A11 in antioxidant stress response in human corneal endothelial cells (HCEnC)...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28635952/yunis-var%C3%A3-n-syndrome-caused-by-biallelic-vac14-mutations
#3
Matthew A Lines, Yoko Ito, Kristin D Kernohan, Wendy Mears, Julie Hurteau-Miller, Sunita Venkateswaran, Leanne Ward, Karine Khatchadourian, Jeff McClintock, Priya Bhola, Philippe M Campeau, Kym M Boycott, Jean Michaud, André Bp van Kuilenburg, Sacha Ferdinandusse, David A Dyment
Yunis-Varón syndrome (YVS) is an autosomal recessive disorder comprising skeletal anomalies, dysmorphism, global developmental delay and intracytoplasmic vacuolation in brain and other tissues. All hitherto-reported pathogenic variants affect FIG4, a lipid phosphatase involved in phosphatidylinositol (3,5)-bisphosphate [PtdIns(3,5)P2] metabolism. FIG4 interacts with PIKfyve, a lipid kinase, via the adapter protein VAC14; all subunits of the resulting complex are essential for PtdIns(3,5)P2 synthesis in the endolysosomal membrane compartment...
June 21, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28626863/prolactin-correction-for-adequacy-of-petrosal-sinus-cannulation-may-diminish-diagnostic-accuracy-in-cushing-s-disease
#4
Sunita Mc De Sousa, Ann I McCormack, Shaun McGrath, David J Torpy
OBJECTIVE: Petrosal venous prolactin concentrations have been promoted to improve the diagnostic accuracy of inferior petrosal sinus sampling (IPSS), beyond that achieved with ACTH measurement alone, in diagnosing a pituitary ACTH source, and determining corticotrophinoma side (L/R). Our objective was to assess the effect of using prolactin to confirm adequacy of petrosal cannulation in a cohort of patients with ACTH-dependent Cushing's syndrome. DESIGN: Retrospective cohort study...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28620431/a-44-year-old-caucasian-male-nonsmoker-with-worsening-difficulty-in-breathing-and-decreased-exercise-tolerance
#5
Sunita Rai, Alina Andreea Ionescu
Can you diagnose this patient and identify the uncommon cause of his illness? http://ow.ly/t4nX30bzJFz.
June 2017: Breathe
https://www.readbyqxmd.com/read/28610474/trunk-function-and-ischial-pressure-offloading-in-individuals-with-spinal-cord-injury
#6
Sharon Gabison, Sunita Mathur, Ethne L Nussbaum, Milos R Popovic, Mary C Verrier
OBJECTIVE: To determine if there is a relationship between trunk function and offloading of the ischial tuberosities in individuals with Spinal Cord Injury (SCI). DESIGN: Prospective cross-sectional evaluation. SETTING: Sub-acute rehabilitation hospital. PARTICIPANTS: Fifteen non-ambulatory participants with complete or incomplete traumatic and non-traumatic SCI, American Spinal Injury Association Impairment Scale (AIS), Classification A-D...
June 14, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28610419/gene-expression-profiling-of-chemokines-and-their-receptors-in-low-and-high-grade-astrocytoma
#7
Ira Sharma, Avninder Singh, Karam Chand Sharma, Sunita Saxena
Background: Despite intense interest in molecular characterization and searches for novel therapeutic targets, the glioblastoma remains a formidable clinical challenge. Among many contributors to gliomagenesis, chemokines have drawn special attention due to their involvement in a plethora of biological processes and pathological conditions. In the present study we aimed to elucidate any pro-gliomagenic chemokine axis and probable roles in development of glioblastoma multiforme (GBM). Method: An array of 84 chemokines, chemokine receptors and related genes were studied by real time PCR with comparison between low grade astrocytoma (diffuse astrocytoma – grade II) and high grade astrocytoma (glioblastoma multiforme – grade IV)...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28607538/phylogenetic-analysis-of-nuclear-encoded-rna-maturases
#8
Sunita Malik, K C Upadhyaya, Sm Paul Khurana
Posttranscriptional processes, such as splicing, play a crucial role in gene expression and are prevalent not only in nuclear genes but also in plant mitochondria where splicing of group II introns is catalyzed by a class of proteins termed maturases. In plant mitochondria, there are 22 mitochondrial group II introns. matR, nMAT1, nMAT2, nMAT3, and nMAT4 proteins have been shown to be required for efficient splicing of several group II introns in Arabidopsis thaliana. Nuclear maturases (nMATs) are necessary for splicing of mitochondrial genes, leading to normal oxidative phosphorylation...
2017: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/28605751/improved-maize-reference-genome-with-single-molecule-technologies
#9
Yinping Jiao, Paul Peluso, Jinghua Shi, Tiffany Liang, Michelle C Stitzer, Bo Wang, Michael S Campbell, Joshua C Stein, Xuehong Wei, Chen-Shan Chin, Katherine Guill, Michael Regulski, Sunita Kumari, Andrew Olson, Jonathan Gent, Kevin L Schneider, Thomas K Wolfgruber, Michael R May, Nathan M Springer, Eric Antoniou, W Richard McCombie, Gernot G Presting, Michael McMullen, Jeffrey Ross-Ibarra, R Kelly Dawe, Alex Hastie, David R Rank, Doreen Ware
Complete and accurate reference genomes and annotations provide fundamental tools for characterization of genetic and functional variation. These resources facilitate the determination of biological processes and support translation of research findings into improved and sustainable agricultural technologies. Many reference genomes for crop plants have been generated over the past decade, but these genomes are often fragmented and missing complex repeat regions. Here we report the assembly and annotation of a reference genome of maize, a genetic and agricultural model species, using single-molecule real-time sequencing and high-resolution optical mapping...
June 12, 2017: Nature
https://www.readbyqxmd.com/read/28603456/cost-effectiveness-analysis-of-the-diarrhea-alleviation-through-zinc-and-oral-rehydration-therapy-dazt-program-in-rural-gujarat-india-an-application-of-the-net-benefit-regression-framework
#10
Samuel D Shillcutt, Amnesty E LeFevre, Christa L Fischer-Walker, Sunita Taneja, Robert E Black, Sarmila Mazumder
BACKGROUND: This study evaluates the cost-effectiveness of the DAZT program for scaling up treatment of acute child diarrhea in Gujarat India using a net-benefit regression framework. METHODS: Costs were calculated from societal and caregivers' perspectives and effectiveness was assessed in terms of coverage of zinc and both zinc and Oral Rehydration Salt. Regression models were tested in simple linear regression, with a specified set of covariates, and with a specified set of covariates and interaction terms using linear regression with endogenous treatment effects was used as the reference case...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28602417/survival-outcomes-with-short-course-radiation-therapy-in-elderly-patients-with-glioblastoma-data-from-a-randomized-phase-3-trial
#11
Douglas Guedes de Castro, Juliana Matiello, Wilson Roa, Sunita Ghosh, Lucyna Kepka, Narendra Kumar, Valery Sinaika, Darejan Lomidze, Dalenda Hentati, Eduardo Rosenblatt, Elena Fidarova
PURPOSE: To perform a subset analysis of survival outcomes in elderly patients with glioblastoma from a randomized phase 3 trial comparing 2 short-course radiation therapy (RT) regimens in elderly and/or frail patients. METHODS AND MATERIALS: The original trial population included elderly and/or frail patients with a diagnosis of glioblastoma. Patients joined the phase 3, randomized, multicenter, prospective, noninferiority trial; were assigned to 1 of 2 groups in a 1:1 ratio, either short-course RT (25 Gy in 5 fractions, arm 1) or commonly used RT (40 Gy in 15 fractions, arm 2); and were stratified by age (<65 years and ≥65 years), Karnofsky Performance Status (KPS), and extent of surgery...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28596363/polymeric-peptide-pigments-with-sequence-encoded-properties
#12
Ayala Lampel, Scott A McPhee, Hang-Ah Park, Gary G Scott, Sunita Humagain, Doeke R Hekstra, Barney Yoo, Pim W J M Frederix, Tai-De Li, Rinat R Abzalimov, Steven G Greenbaum, Tell Tuttle, Chunhua Hu, Christopher J Bettinger, Rein V Ulijn
Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In these structures, phenols are presented in a (supra-)molecular context dictated by the positions of the amino acids in the peptide sequence...
June 9, 2017: Science
https://www.readbyqxmd.com/read/28592509/comparative-functional-genomic-screens-of-three-yeast-deletion-collections-reveal-unexpected-effects-of-genotype-in-response-to-diverse-stress
#13
Erica Acton, Amy Huei-Yi Lee, Pei Jun Zhao, Stephane Flibotte, Mauricio Neira, Sunita Sinha, Jennifer Chiang, Patrick Flaherty, Corey Nislow, Guri Giaever
The Yeast Knockout (YKO) collection has provided a wealth of functional annotations from genome-wide screens. An unintended consequence is that 76% of gene annotations derive from one genotype. The nutritional auxotrophies in the YKO, in particular, have phenotypic consequences. To address this issue, 'prototrophic' versions of the YKO collection have been constructed, either by introducing a plasmid carrying wild-type copies of the auxotrophic markers (Plasmid-Borne, PBprot) or by backcrossing (Backcrossed, BCprot) to a wild-type strain...
June 2017: Open Biology
https://www.readbyqxmd.com/read/28592313/impact-of-community-initiated-kangaroo-mother-care-on-survival-of-low-birth-weight-infants-study-protocol-for-a-randomized-controlled-trial
#14
Sarmila Mazumder, Sunita Taneja, Suresh Kumar Dalpath, Rakesh Gupta, Brinda Dube, Bireshwar Sinha, Kiran Bhatia, Sachiyo Yoshida, Ole Frithjof Norheim, Rajiv Bahl, Halvor Sommerfelt, Nita Bhandari, Jose Martines
BACKGROUND: Around 70% neonatal deaths occur in low birth weight (LBW) babies. Globally, 15% of babies are born with LBW. Kangaroo Mother Care (KMC) appears to be an effective way to reduce mortality and morbidity among LBW babies. KMC comprises of early and continuous skin-to-skin contact between mother and baby as well as exclusive breastfeeding. Evidence derived from hospital-based studies shows that KMC results in a 40% relative reduction in mortality, a 58% relative reduction in the risk of nosocomial infections or sepsis, shorter hospital stay, and a lower risk of lower respiratory tract infections in babies with birth weight <2000 g...
June 7, 2017: Trials
https://www.readbyqxmd.com/read/28588982/efficacy-of-three-feeding-regimens-for-home-based-management-of-children-with-uncomplicated-severe-acute-malnutrition-a-randomised-trial-in-india
#15
Nita Bhandari, Sanjana Brahmawar Mohan, Anuradha Bose, Sharad D Iyengar, Sunita Taneja, Sarmila Mazumder, Ruby Angeline Pricilla, Kirti Iyengar, Harshpal Singh Sachdev, Venkata Raghava Mohan, Virendra Suhalka, Sachiyo Yoshida, Jose Martines, Rajiv Bahl
OBJECTIVE: To assess the efficacy of ready-to-use therapeutic food (RUTF), centrally produced RUTF (RUTF-C) or locally prepared RUTF (RUTF-L) for home-based management of uncomplicated severe acute malnutrition (SAM) compared with micronutrient-enriched (augmented) energy-dense home-prepared foods (A-HPF, the comparison group). METHODS: In an individually randomised multicentre trial, we enrolled 906 children aged 6-59 months with uncomplicated SAM. The children enrolled were randomised to receive RUTF-C, RUTF-L or A-HPF...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28588319/subcutaneous-adiposity-is-an-independent-predictor-of-mortality-in-cancer-patients
#16
Maryam Ebadi, Lisa Martin, Sunita Ghosh, Catherine J Field, Richard Lehner, Vickie E Baracos, Vera C Mazurak
BACKGROUND: Prognostic significance of adiposity, at the time of cancer diagnosis, on survival is not clear. Body mass index (kg m(-2)) does not provide an appropriate assessment of body composition; therefore, the concept of the 'obesity paradox' needs to be investigated based on the prognostic significance of fat and muscle. Independent prognostic significance of adipose tissue in predicting mortality, importance of visceral and subcutaneous adiposity in the presence and absence of sarcopenia on survival, was investigated...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28581374/wephren-a-global-prison-health-research-network
#17
Emma Plugge, Sunita Stürup-Toft, Éamonn J O'Moore, Lars Møller
No abstract text is available yet for this article.
June 12, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28576734/protocol-for-the-match-study-mindfulness-and-tai-chi-for-cancer-health-a-preference-based-multi-site-randomized-comparative-effectiveness-trial-cet-of-mindfulness-based-cancer-recovery-mbcr-vs-tai-chi-qigong-tcq-for-cancer-survivors
#18
Linda E Carlson, Erin L Zelinski, Michael Speca, Lynda G Balneaves, Jennifer M Jones, Daniel Santa Mina, Peter M Wayne, Tavis S Campbell, Janine Giese-Davis, Peter Faris, Jennifer Zwicker, Kamala Patel, Tara L Beattie, Steve Cole, Kirsti Toivonen, Jill Nation, Philip Peng, Bruce Thong, Raimond Wong, Sunita Vohra
PURPOSE: A growing number of cancer survivors suffer high levels of distress, depression and stress, as well as sleep disturbance, pain and fatigue. Two different mind-body interventions helpful for treating these problems are Mindfulness-Based Cancer Recovery (MBCR) and Tai Chi/Qigong (TCQ). However, while both interventions show efficacy compared to usual care, they have never been evaluated in the same study or directly compared. This study will be the first to incorporate innovative design features including patient choice while evaluating two interventions to treat distressed cancer survivors...
May 30, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28571132/cardiovascular-response-and-serum-interleukin-6-level-in-concentric-vs-eccentric-exercise
#19
Mayank Agarwal, Shraddha Singh, Jagdish Narayan, Shivani Pandey, Sunita Tiwari, Priyanka Sharma
INTRODUCTION: Cardiovascular Disease (CVD) is a leading cause of morbidity and mortality in India. Resistance exercise is strongly recommended for implementation in CVD prevention programs. Dynamic resistance exercise comprises of concentric (muscle shortening) and eccentric (muscle lengthening) phase. The contraction of skeletal muscle promotes the synthesis and secretion of cytokines and peptides from myocytes, known as 'myokines'. Interleukin-6 (IL-6) is the first myokine to be released in the blood in response to exercise...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28567113/research-ethics-governance-in-times-of-ebola
#20
Doris Schopper, Raffaella Ravinetto, Lisa Schwartz, Eunice Kamaara, Sunita Sheel, Michael J Segelid, Aasim Ahmad, Angus Dawson, Jerome Singh, Amar Jesani, Ross Upshur
The Médecins Sans Frontières (MSF) ethics review board (ERB) has been solicited in an unprecedented way to provide advice and review research protocols in an 'emergency' mode during the recent Ebola epidemic. Twenty-seven Ebola-related study protocols were reviewed between March 2014 and August 2015, ranging from epidemiological research, to behavioural research, infectivity studies and clinical trials with investigational products at (very) early development stages. This article examines the MSF ERB's experience addressing issues related to both the process of review and substantive ethical issues in this context...
April 2017: Public Health Ethics
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