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https://www.readbyqxmd.com/read/28095901/risk-assessment-tools-to-predict-location-of-discharge-and-need-for-supportive-services-for-medical-patients-after-discharge-from-hospital-a-systematic-review-protocol
#1
Daniel M Kobewka, Daniel McIsaac, Michaël Chassé, Kednapa Thavorn, Sunita Mulpuru, Luke T Lavallée, Shane English, Justin Presseau, Alan J Forster
BACKGROUND: Patients who are discharged from hospital after an acute medical illness often have impaired function that prevents them from returning to their previous place of residence. Assessing each patient's post-discharge needs takes time and resources but is important in order to reduce unplanned readmissions and adverse events post-discharge. METHODS/DESIGN: We will conduct a systematic review to synthesize the evidence on prognostic models and their reported accuracy in predicting the location of discharge after a medical admission to an acute care hospital...
January 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28091570/increasing-the-potential-for-malaria-elimination-by-targeting-zoophilic-vectors
#2
Jessica L Waite, Sunita Swain, Penelope A Lynch, S K Sharma, Mohammed Asrarul Haque, Jacqui Montgomery, Matthew B Thomas
Countries in the Asia Pacific region aim to eliminate malaria by 2030. A cornerstone of malaria elimination is the effective management of Anopheles mosquito vectors. Current control tools such as insecticide treated nets or indoor residual sprays target mosquitoes in human dwellings. We find in a high transmission region in India, malaria vector populations show a high propensity to feed on livestock (cattle) and rest in outdoor structures such as cattle shelters. We also find evidence for a shift in vector species complex towards increased zoophilic behavior in recent years...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087540/international-evidence-based-consensus-diagnostic-criteria-for-hhv-8-negative-idiopathic-multicentric-castleman-disease
#3
David C Fajgenbaum, Thomas S Uldrick, Adam Bagg, Dale Frank, David Wu, Gordan Srkalovic, David Simpson, Amy Y Liu, David Menke, Shanmuganathan Chandrakasan, Mary Jo Lechowicz, Raymond S M Wong, Sheila Pierson, Michele Paessler, Jean-François Rossi, Makoto Ide, Jason Ruth, Michael Croglio, Alexander Suarez, Vera Krymskaya, Amy Chadburn, Gisele Colleoni, Sunita Nasta, Raj Jayanthan, Christopher S Nabel, Corey Casper, Angela Dispenzieri, Alexander Fosså, Dermot Kelleher, Razelle Kurzrock, Peter Voorhees, Ahmet Dogan, Kazuyuki Yoshizaki, Frits van Rhee, Eric Oksenhendler, Elaine S Jaffe, Kojo S J Elenitoba-Johnson, Megan S Lim
Human Herpesvirus-8(HHV-8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction due to a cytokine storm often including interleukin-6. iMCD accounts for one-third to one-half of all cases of MCD and can occur in individuals of any age. Accurate diagnosis is challenging, as no standard diagnostic criteria or diagnostic biomarkers currently exist, and there is significant overlap with malignant, autoimmune, and infectious disorders...
January 13, 2017: Blood
https://www.readbyqxmd.com/read/28080264/convergent-and-criterion-validity-of-the-cogstate-computerized-brief-battery-cognitive-assessment-in-women-with-and-without-breast-cancer
#4
Sunita K Patel, Adrienne M Meier, Nathaniel Fernandez, Tracy T Y Lo, Colleen Moore, Nicole Delgado
OBJECTIVE: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional 'pencil and-paper' neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized tests in breast cancer survivors, a group known to present with mostly mild, subtle cognitive dysfunction...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28078549/functionalized-ionic-liquid-assisted-chromatography-free-synthesis-of-bis-indolyl-methanes
#5
Sunita Choudhary, Khima Pandey, Saroj Budania, Anil Kumar
A chromatography-free synthesis of bis(indolyl)methanes has been developed using sulfonic acid and sulfonyl hydrazine-functionalized ionic liquids as catalyst and scavenger, respectively. The employed excess aldehyde for completion of the reaction was scavenged by sulfonyl hydrazine-functionalized ionic liquid. Purification of products without column chromatography, ease of monitoring and shorter reaction time are the salient features of the developed protocol. The reuse and regeneration of the catalyst and scavenger have been achieved up to 5 and 2 times, respectively, without significant loss of activity...
January 11, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28069697/increased-canonical-wnt-%C3%AE-catenin-signalling-and-myxomatous-valve-disease
#6
EDITORIAL
Sunita Chopra, Nadia Al-Sammarraie, Yimu Lai, Mohamad Azhar
No abstract text is available yet for this article.
January 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28065804/limited-naturally-occurring-escape-in-broadly-neutralizing-antibody-epitopes-in-hepatitis-c-glycoprotein-e2-and-constrained-sequence-usage-in-acute-infection
#7
Chaturaka Rodrigo, Melanie R Walker, Preston Leung, Auda A Eltahla, Jason Grebely, Gregory J Dore, Tanya Applegate, Kimberly Page, Sunita Dwivedi, Julie Bruneau, Meghan D Morris, Andrea L Cox, William Osburn, Arthur Y Kim, Janke Schinkel, Naglaa H Shoukry, Georg M Lauer, Lisa Maher, Margaret Hellard, Maria Prins, Fabio Luciani, Andrew R Lloyd, Rowena A Bull
Broadly neutralizing antibodies have been associated with spontaneous clearance of the hepatitis C infection as well as viral persistence by immune escape. Further study of neutralizing antibody epitopes is needed to unravel pathways of resistance to virus neutralization, and to identify conserved regions for vaccine design. All reported broadly neutralizing antibody (BNAb) epitopes in the HCV Envelope (E2) glycoprotein were identified. The critical contact residues of these epitopes were mapped onto the linear E2 sequence...
January 5, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28061004/objective-physical-and-mental-markers-of-self-reported-fatigue-in-women-undergoing-neo-adjuvant-chemotherapy-for-early-stage-breast-cancer
#8
Joanne E Mortimer, Sarah Waliany, Christina M Dieli-Conwright, Sunita K Patel, Arti Hurria, Joseph Chao, Brian Tiep, Carolyn E Behrendt
BACKGROUND: Objective, treatment-independent markers of cancer-related fatigue are needed to advance clinical trials. In the current study, the authors evaluated physical, neurocognitive, and serologic markers for correlation with self-reported fatigue before and after (neo)adjuvant chemotherapy for patients with early-stage breast cancer. METHODS: Women with AJCC TNM Stage I-III breast cancer consented to assessment before and after the completion of 4 cycles of dose-dense doxorubicin and cyclophosphamide...
January 6, 2017: Cancer
https://www.readbyqxmd.com/read/28058815/small-rnaome-profiling-from-human-skeletal-muscle-novel-mirnas-and-their-targets-associated-with-cancer-cachexia
#9
Ashok Narasimhan, Sunita Ghosh, Cynthia Stretch, Russell Greiner, Oliver F Bathe, Vickie Baracos, Sambasivarao Damaraju
BACKGROUND: MicroRNAs (miRs) are small non-coding RNAs that regulate gene (mRNA) expression. Although the pathological role of miRs have been studied in muscle wasting conditions such as myotonic and muscular dystrophy, their roles in cancer cachexia (CC) are still emerging. OBJECTIVES: The objectives are (i) to profile human skeletal muscle expressed miRs; (ii) to identify differentially expressed (DE) miRs between cachectic and non-cachectic cancer patients; (iii) to identify mRNA targets for the DE miRs to gain mechanistic insights; and (iv) to investigate if miRs show potential prognostic and predictive value...
January 6, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28058230/outcomes-in-randomized-controlled-trials-of-exercise-interventions-in-solid-organ-transplant
#10
Tania Janaudis-Ferreira, Sunita Mathur, Stacey Konidis, Catherine M Tansey, Cecile Beaurepaire
AIM: To identify the outcome measures that have been used in randomized controlled trials (RCTs) of exercise training in solid organ transplant (SOT) recipients and to link these outcomes to the International Classification of Functioning, Disability and Health (ICF) framework. METHODS: Electronic literature searches of MEDLINE, EMBASE, CINAHL, Cochrane, Scopus, and Web of Science were performed. We sought RCTs that investigated the effect of exercise training in SOT recipients...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28055124/interventions-for-the-management-of-oral-lichen-planus-a-review-of-the-conventional-and-novel-therapies
#11
REVIEW
Shikha Gupta, Sujoy Ghosh, Sunita Gupta
OBJECTIVE: This narrative review focuses on the rationale & role of conventional and newer therapies in the management of Oral lichen planus with emphasis on randomized controlled trials reported over 2 decades. MATERIALS AND METHODS: Literature search was conducted to identify randomized controlled trials for management of OLP from 1/1/1995 to 31/12/2015; Medline, and Cochrane databases complemented with manual search was used. Primary outcome as resolution of pain was evaluated with analysis of clinical resolution of erythema and ulceration as secondary outcome...
January 5, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28050452/primary-abdominal-pregnancy-a-case-report
#12
Sunita Dubey, Mohit Satodiya, Priyanka Garg, Mamta Rani
Abdominal pregnancy is a potentially life threatening form of ectopic gestation with an incidence of 1% of all the ectopic pregnancies. Rarely, it may reach at advanced gestation and a viable fetal outcome is indeed a rare event. Most of them are terminated earlier due to poor fetal prognosis and higher chances of maternal mortality secondary to haemorrhagic shock following spontanous placental separation. A high index of suspicion is important for making a diagnosis of abdominal pregnancy and its timely management after correct diagnosis...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28039806/silica-supported-au-hollow-sio2-particles-with-outstanding-catalytic-activity-prepared-via-block-copolymer-template-approach
#13
Aruni Shajkumar, Bhanu Nandan, Sunita Sanwaria, Victoria Albrecht, Marcin Libera, Myong-Hoon Lee, Gudrun Auffermann, Manfred Stamm, Andriy Horechyy
Catalytically active Au@hollow-SiO2 particles embedded in porous silica support (Au@hollow-SiO2@PSS) were prepared by using spherical micelles from poly(styrene)-block-poly(4-vinyl pyridine) block copolymer as a sacrificial template. Drastic increase of the shell porosity was observed after pyrolytic removal of polymeric template because the stretched poly(4-vinyl pyridine) chains interpenetrating with silica shell acted as an effective porogen. The embedding of Au@hollow-SiO2 particles in porous silica support prevented their fusion during pyrolysis...
December 23, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28032093/pigmented-villonodular-synovitis-of-proximal-tibiofibular-joint-rare-site-of-involvement-treated-with-medical-management
#14
Ashish Gulia, Sunita Dhanda, Ajay Puri, Mukta Ramadwar
No abstract text is available yet for this article.
October 2016: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28030352/characterization-of-immunoreactive-proteins-of-setaria-cervi-isolated-by-preparative-polyacrylamide-gel-electrophoresis
#15
Priyanka Priyadarshi, Piyush Dravid, Inayat Hussain Sheikh, Sunita Saxena, Ashish Tandon, Deep C Kaushal, Shakir Ali, Nuzhat A Kaushal
Filarial parasites are complex mixtures of antigenic proteins and characterization of these antigenic molecules is essential to identify the diagnostically important filaria-specific antigens. In the present study, we have fractionated the somatic extracts from adults of Setaria cervi (bovine filarial parasite) on preparative SDS-polyacrylamide gel electrophoresis and tested the immunoreactivity of the separated gel fractions with polyclonal antibodies against filarial excretory-secretory antigens as well as filarial patients sera...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28028334/liquid-based-versus-conventional-cytology-in-solid-pediatric-neoplasm-comparison-of-their-diagnostic-and-morphological-spectra
#16
Preeti Agarwal, Sunita Yadav, Archana Kumar, Madhu M Goel
BACKGROUND: Conventional cytology (CC) is a well-established and effective methodology for the evaluation of pediatric tumors. Liquid-based cytology (LBC) is a better technique of smear preparation and is at present the standard protocol in cervical cytology samples. AIMS: In the present study, we analyzed both smear preparatory techniques in fine-needle aspiration (FNA) samples from solid pediatric neoplasms in terms of adequacy and efficacy with objectives to study the changes in background and morphology of tumor cells in LBC smears...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28017796/analysis-of-transcriptional-variability-in-a-large-human-ipsc-library-reveals-genetic-and-non-genetic-determinants-of-heterogeneity
#17
Ivan Carcamo-Orive, Gabriel E Hoffman, Paige Cundiff, Noam D Beckmann, Sunita L D'Souza, Joshua W Knowles, Achchhe Patel, Dimitri Papatsenko, Fahim Abbasi, Gerald M Reaven, Sean Whalen, Philip Lee, Mohammad Shahbazi, Marc Y R Henrion, Kuixi Zhu, Sven Wang, Panos Roussos, Eric E Schadt, Gaurav Pandey, Rui Chang, Thomas Quertermous, Ihor Lemischka
Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease modeling and regenerative medicine. We have used RNA-sequencing analysis and linear mixed models to examine the sources of gene expression variability in 317 human iPSC lines from 101 individuals. We found that ∼50% of genome-wide expression variability is explained by variation across individuals and identified a set of expression quantitative trait loci that contribute to this variation. These analyses coupled with allele-specific expression show that iPSCs retain a donor-specific gene expression pattern...
December 2, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/28010729/cholesterol-levels-and-long-term-rates-of-community-acquired-sepsis
#18
Faheem W Guirgis, John P Donnelly, Sunita Dodani, George Howard, Monika M Safford, Emily B Levitan, Henry E Wang
BACKGROUND: Dyslipidemia is a risk factor for cardiovascular disease, with elevated low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) recognized as risk factors for acute coronary events. Studies suggest an association between low cholesterol levels and poor outcomes in acute sepsis. We sought to determine the relationship between baseline cholesterol levels and long-term rates of sepsis. METHODS: We used data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, a population-based cohort of 30,239 community-dwelling adults...
December 23, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27999107/heparanase-overexpression-induces-glucagon-resistance-and-protects-animals-from-chemically-induced-diabetes
#19
Dahai Zhang, Fulong Wang, Nathaniel Lal, Amy Pei-Ling Chiu, Andrea Wan, Jocelyn Jia, Denise Bierende, Stephane Flibotte, Sunita Sinha, Ali Asadi, Xiaoke Hu, Farnaz Taghizadeh, Thomas Pulinilkunnil, Corey Nislow, Israel Vlodavsky, James D Johnson, Timothy J Kieffer, Bahira Hussein, Brian Rodrigues
Heparanase, a protein with enzymatic and nonenzymatic properties, contributes toward disease progression and prevention. In the current study, a fortuitous observation in transgenic mice globally overexpressing heparanase (hep-tg) was the discovery of improved glucose homeostasis. We examined the mechanisms that contribute toward this improved glucose metabolism. Heparanase overexpression was associated with enhanced glucose-stimulated insulin secretion and hyperglucagonemia, in addition to changes in islet composition and structure...
January 2017: Diabetes
https://www.readbyqxmd.com/read/27994429/odontogenic-myxofibroma-of-gingiva-in-a-pediatric-patient-with-tuberous-sclerosis-a-rare-case-report
#20
Nidhi Bhoyar, Sunita Gupta, Sujoy Ghosh
Tuberous sclerosis complex (TSC) is a rare multisystem genetic disease, with an estimated incidence of 1 in 6000-1 in 10,000. TSC is an autosomal dominant syndrome involving heart, kidneys, lungs, and skin. The classic triad of TSC is seizures, mental retardation, and angiofibromas; this triad occurs in only 29% of patients. The clinical diagnostic guidelines on TSC are prepared based on clinical features, radiographic findings. The most common oral manifestations of TSC are fibroma, gingival hyperplasia, and enamel hypoplasia...
October 2016: Contemporary Clinical Dentistry
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