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https://www.readbyqxmd.com/read/28338469/the-utility-of-thyroid-ultrasonography-in-the-management-of-thyroid-nodules
#1
Gary Gamme, Tyler Parrington, Edward Wiebe, Sunita Ghosh, Brendan Litt, David C Williams, Todd P W McMullen
BACKGROUND: Ultrasonography for thyroid nodules is one of the most common imaging tests performed in the general population. Details from ultrasound reports guide biopsies and surgery. This study quantifies the completeness of these reports based on Thyroid Imaging and Reporting System (TI-RADS) criteria and considers their utility in predicting malignant disease. METHODS: We retrospectively reviewed ultrasound reports for 329 thyroidectomy patients and extracted data elements using the TI-RADS criteria: nodule size, echogenicity, margins, vascularity, solid/cystic composition and the presence or absence of microcalcifications and the halo sign...
April 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28333411/utility-of-peripheral-blood-immunophenotyping-by-flow-cytometry-in-the-diagnosis-of-pediatric-acute-leukemia
#2
Laura K Metrock, Ryan J Summers, Sunita Park, Scott Gillespie, Sharon Castellino, Glen Lew, Frank G Keller
BACKGROUND: Childhood acute leukemia is traditionally diagnosed from a bone marrow aspirate (BMA). New-onset acute leukemia patients do not always have visible circulating blasts in the peripheral blood (PB) at diagnosis. While the role of bone marrow flow cytometry for the diagnosis of acute leukemia is well established, the utility of PB flow cytometry (PBFC) is unknown. We performed a single-institution retrospective analysis to compare PBFC versus BMA in establishing or excluding a diagnosis of childhood acute leukemia...
March 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28330802/orofacial-trauma-in-rural-india-a-clinical-study
#3
Sunita Malik, Gurdarshan Singh, Gagandeep Kaur, Sunil Yadav, Hitesh C Mittal
PURPOSE: Orofacial trauma is becoming a leading medical problem worldwide. Most of the studies pertaining to orofacial trauma have been done in urban areas but very little scientific literature is available for rural areas. METHODS: A prospective medical institute-based study of orofacial injury patients was carried out from May 2013 to April 2016 (36 Months). Data regarding incidence, age and sex distribution, causes, types and site of injury, treatment modalities and trauma associated complications were collected and analysed...
February 24, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28330316/phytotoxicity-and-oxidative-stress-perspective-of-two-selected-nanoparticles-in-brassica-juncea
#4
Sunita Rao, Gyan Singh Shekhawat
This study elaborates the consequences of oxidative stress caused by copper oxide (CuO) and titanium dioxide (TiO2) nanoparticles (NPs) in Brassica juncea. Effect of these two NPs on plant physiology, reactive oxygen scavenging enzyme system (ascorbate peroxidase, catalase, superoxide dismutase), proline content and lipid peroxidation has been estimated in leaves as well as root tissues. Bioaccumulation of NPs has also been evaluated in the current study and the interrelated cascade of the enzymatic system with H2O2 production was identified...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327275/a-population-based-study-of-outcomes-in-patients-with-gastrointestinal-neuroendocrine-tumours
#5
Todd McMullen, Akram Al-Jahdali, Christopher de Gara, Sunita Ghosh, Alexander McEwan, Daniel Schiller
BACKGROUND: Neuroendocrine tumours (NETs) are heterogeneous, with varying presentations and treatment options. To our knowledge, there are no randomized and few long-term studies of patient outcomes. The role of surgical and medical therapy for local, regional and metastatic disease continues to be evaluated in the literature. METHODS: We conducted a population-based search of the provincial cancer registry to identify patients with gastrointestinal NETs from the stomach, small intestine, colon and rectum diagnosed between 1990 and 2005 and assessed their outcomes...
April 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28325850/phenotypic-diversity-and-genotypic-flexibility-of-burkholderia-cenocepacia-during-long-term-chronic-infection-of-cystic-fibrosis-lungs
#6
Amy Huei-Yi Lee, Stephane Flibotte, Sunita Sinha, Adrianna Paiero, Rachel L Ehrlich, Sergey Balashov, Garth D Ehrlich, James E A Zlosnik, Joshua Chang Mell, Corey Nislow
Chronic bacterial infections of the lung are the leading cause of morbidity and mortality in cystic fibrosis patients. Tracking bacterial evolution during chronic infections can provide insights into how host selection pressures-including immune responses and therapeutic interventions-shape bacterial genomes. We carried out genomic and phenotypic analyses of 215 serially collected Burkholderia cenocepacia isolates from 16 cystic fibrosis patients, spanning a period of 2-20 yr and a broad range of epidemic lineages...
March 21, 2017: Genome Research
https://www.readbyqxmd.com/read/28323952/randomized-controlled-trial-of-a-mufa-or-fiber-rich-diet-on-hepatic-fat-in-pre-diabetes
#7
Isabel Errazuriz, Simmi Dube, Michael Slama, Roberto Visentin, Sunita Nayar, Helen O'Connor, Claudio Cobelli, Swapan Kumar Das, Ananda Basu, Walter Karl Kremers, John Port, Rita Basu
Context: Increased prevalence of type 2 diabetes mellitus and prediabetes worldwide has been attributed, at least in part, to a modern lifestyle, in particular, to an unhealthy diet. Objective: To evaluate whether 12 weeks of high MUFA or fiber-rich weight maintenance diet lowers hepatic fat and improves glucose tolerance in people with prediabetes. Design: Subjects underwent a [6, 6-2H2] labeled 75 g oral glucose tolerance test to estimate hepatic insulin sensitivity (Siliver) along with measurement of liver fat fraction (LFF) using magnetic resonance spectroscopy before and after intervention...
March 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28300452/sun-smart-practices-amongst-school-students-grades-5-7-and-9-in-alberta-canada
#8
Divya Jha, Shankar Jha, Sunita Ghosh, Michael Smylie, Muba Taher
OBJECTIVES: The aim of this study was to assess the current knowledge children possess on melanoma and sun-protective behaviour. METHODS: A one-page survey was administered to students in grades 5, 7, and 9. RESULTS: Three hundred ninety-two students from 11 schools in Edmonton were surveyed. Seventy-one percent of students knew that sun exposure can cause skin cancers. Sixty-nine percent were taught by their parents about sun protection, but only 44% of students received similar instructions from teachers...
March 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28298752/quality-of-labor-epidural-analgesia-and-maternal-outcome-with-levobupivacaine-and-ropivacaine-a-double-blinded-randomized-trial
#9
T Senthil Kumar, P Rani, V R Hemanth Kumar, Sunita Samal, S Parthasarathy, M Ravishankar
BACKGROUND: Quality of labor analgesia plays a vital role in the maternal outcome. Very few literature are available analyzing the quality of epidural labor analgesia. AIM: The aim of this study was to compare the effectiveness of 0.1% levobupivacaine and 0.1% ropivacaine with fentanyl as an adjuvant for epidural labor analgesia in terms of onset, duration, quality of analgesia, and degree of motor blockade. METHODOLOGY: Sixty nulliparous parturients, with singleton uncomplicated pregnancy, were recruited by continuous sampling...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28292010/the-anti-allergic-and-anti-inflammatory-effects-of-benjakul-extract-a-thai-traditional-medicine-its-constituent-plants-and-its-some-pure-constituents-using-in-vitro-experiments
#10
Sunita Makchuchit, Ruchilak Rattarom, Arunporn Itharat
Benjakul (BJK), a Thai traditional medicine preparation, has long been used for balanced health, controlled abnormal of element in the body, carminative, and relief of flatulence. It is composed of five plants: Piper interruptum Opiz., Piper longum L., Piper sarmentosum Roxb., Plumbago indica L., and Zingiber officinale Roscoe. The ethanolic extracts of BJK, its five individual plants, and pure constituents of BJK were investigated for their anti-allergic activity using immunoglobulin E (IgE)-sensitized β-hexosaminidase in the rat basophilic leukemia-2H3 (RBL-2H3) cells and anti-inflammatory activity using lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) in the murine macrophage (RAW 264...
March 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28288608/the-role-of-community-engagement-in-the-adoption-of-new-agricultural-biotechnologies-by-farmers-the-case-of-the-africa-harvest-tissue-culture-banana-in-kenya
#11
Sunita V S Bandewar, Florence Wambugu, Emma Richardson, James V Lavery
BACKGROUND: The tissue culture banana (TCB) is a biotechnological agricultural innovation that has been adopted widely in commercial banana production. In 2003, Africa Harvest Biotech Foundation International (AH) initiated a TCB program that was explicitly developed for smallholder farmers in Kenya to help them adopt the TCB as a scalable agricultural business opportunity. At the heart of the challenge of encouraging more widespread adoption of the TCB is the question: what is the best way to introduce the TCB technology, and all its attendant practices and opportunities, to smallholder farmers...
March 13, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28284809/discovery-of-orally-active-hepatoselective-glucokinase-activators-for-treatment-of-type-ii-diabetes-mellitus
#12
Jiayi Xu, Songnian Lin, Robert W Myers, Maria E Trujillo, Michele J Pachanski, Sunita Malkani, Hsuan-Shen Chen, Zhesheng Chen, Brian Campbell, George J Eiermann, Nadine Elowe, Brian T Farrer, Wen Feng, Qinghong Fu, Roman Kats-Kagan, Michael Kavana, Daniel R McMasters, Kaushik Mitra, Xinchun Tong, Libo Xu, Fengqi Zhang, Rui Zhang, George H Addona, Joel P Berger, Bei Zhang, Emma R Parmee
Systemically acting glucokinase activators (GKA) have been demonstrated in clinical trials to effectively lower blood glucose in patients with type II diabetes. However, mechanism-based hypoglycemia is a major adverse effect that limits the therapeutic potential of these agents. We hypothesized that the predominant mechanism leading to hypoglycemia is GKA-induced excessive insulin secretion from pancreatic β-cells at (sub-)euglycemic levels. We further hypothesized that restricting GK activation to hepatocytes would maintain glucose-lowering efficacy while significantly reducing hypoglycemic risk...
October 31, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28284804/novel-highly-potent-systemic-glucokinase-activators-for-the-treatment-of-type-2-diabetes-mellitus
#13
Jiayi Xu, Songnian Lin, Robert W Myers, George Addona, Joel P Berger, Brian Campbell, Hsuan-Shen Chen, Zhesheng Chen, George J Eiermann, Nadine H Elowe, Brian T Farrer, Wen Feng, Qinghong Fu, Roman Kats-Kagan, Michael Kavana, Sunita Malkani, Daniel R McMasters, Kaushik Mitra, Michele J Pachanski, Xinchun Tong, Maria E Trujillo, Libo Xu, Bei Zhang, Fengqi Zhang, Rui Zhang, Emma R Parmee
Glucokinase (GK, hexokinase IV) is a unique hexokinase that plays a central role in mammalian glucose homeostasis. Glucose phosphorylation by GK in the pancreatic β-cell is the rate-limiting step that controls glucose-stimulated insulin secretion. Similarly, GK-mediated glucose phosphorylation in hepatocytes plays a major role in increasing hepatic glucose uptake and metabolism and possibly lowering hepatic glucose output. Small molecule GK activators (GKAs) have been identified that increase enzyme activity by binding to an allosteric site...
October 31, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28277969/involvement-of-nitric-oxide-in-enhanced-germination-and-seedling-growth-of-magnetoprimed-maize-seeds
#14
Pinke Patel, Guruprasad Kadur Narayanaswamy, Sunita Kataria, Lokesh Baghel
Nitric oxide (NO) is a highly reactive gaseous free radical, which in plants was found to stimulate seed germination and ending of dormancy. Experiments were conducted to study the effect of NO inhibitors sodium tungstate (ST) and Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME), NADPH oxidase inhibitor diphenyleneiodonium (DPI) and NO donor sodium nitroprusside (SNP) on untreated and magnetoprimed maize (Zea mays var: GSF-2) seeds. Treatment of maize seeds with these inhibitors inhibited germination related parameters like seedling length, fresh weight, dry weight and vigour indices and α-amylase activity of maize seeds under laboratory conditions, whereas NO donor (SNP) promoted all these parameters...
February 21, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28274006/twin-reversed-arterial-perfusion-to-treat-or-not
#15
Sunita Dubey, Meesha Verma, Poonam Goel, Rps Punia
Acardiac twinning or Twin Reverse Arterial Perfusion (TRAP)-sequence is a rare complication of monochorionic twin pregnancy. Whether to start elective or therapeutic treatment in TRAP-sequence is still controversial. In the present case, acardiac twin was not diagnosed till her delivery at 39 weeks. A healthy baby weighing 2.45 kg was delivered along with another amorphous mass (acardiac twin) of about 150 g which was attached to the placenta with a short and separate cord. As outcome of normal twin vary according to the growth of acardiac twin, frequent follow-up of the normal twin is required to look for the features of heart failure...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273084/vitamin-d-deficiency-predicts-infections-in-young-north-indian-children-a-secondary-data-analysis
#16
Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Bireshwar Sinha, Ravi Prakash Upadhyay, Maharaj Kishan Bhan, Tor A Strand
BACKGROUND: Recent studies have demonstrated a relationship between poor vitamin D status and respiratory infections and diarrhea among young children. Acute lower respiratory infections (ALRI) and diarrhea are among the two most important causes of death in under-5 children. In this paper, we examined the extent to which vitamin-D deficiency (<10 ng/ml) predicts ALRI, clinical pneumonia and diarrhea among 6 to 30 months old children. METHODS: We used data from a randomized controlled trial (RCT) of daily folic acid and/or vitamin B12 supplementation for six months in 6 to 30 months old children conducted in Delhi, India...
2017: PloS One
https://www.readbyqxmd.com/read/28267890/modified-benzoxazolone-derivative-as-18-kda-tspo-ligand
#17
Neelam Kumari, Nidhi Chadha, Pooja Srivastava, Lokesh Chandra Mishra, Sunita Bhagat, Anil K Mishra, Anjani K Tiwari
We have synthesized six new congeners of acetamido-benzoxazolone for Translocator Protein [18 kDa, TSPO] imaging. The best in vitro binding affinity (10.8 ± 1.2 nM) for TSPO was found for N-methyl-2-(5-(naphthalen-1-yl)-2-oxobenzo[d]oxazol-3(2H)-yl)-N-phenylacetamide, (NBMP). NBMP was synthesised by suzuki coupling reaction between 2-(5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl)-N-phenylacetamide and napthalene-1-boronic acid. Computational docking and simulation studies showed not much impact of intersubject variability on binding which is one of the major drawbacks of several TSPO ligands...
March 7, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28262633/diagnostic-validation-of-three-test-methods-for-detection-of-cyprinid-herpesvirus-3-cyhv-3
#18
Sharon C Clouthier, Carol McClure, Tamara Schroeder, Megan Desai, Laura Hawley, Sunita Khatkar, Melissa Lindsay, Geoff Lowe, Jon Richard, Eric D Anderson
Cyprinid herpesvirus 3 (CyHV-3) is the aetiological agent of koi herpesvirus disease in koi and common carp. The disease is notifiable to the World Organisation for Animal Health. Three tests-quantitative polymerase chain reaction (qPCR), conventional PCR (cPCR) and virus isolation by cell culture (VI)-were validated to assess their fitness as diagnostic tools for detection of CyHV-3. Test performance metrics of diagnostic accuracy were sensitivity (DSe) and specificity (DSp). Repeatability and reproducibility were measured to assess diagnostic precision...
March 6, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28256462/morphological-spectrum-of-mediastinal-lesions-with-special-emphasis-on-evaluation-of-needle-biopsy-an-experience-from-a-tertiary-care-hospital
#19
Riti Aggarwal, Seema Rao, Prem Chopra, Sunita Bhalla, C L Vijay, Belal Bin Asaf, Arvind Kumar
BACKGROUND & OBJECTIVES: Mediastinal lesions are uncommon and are infrequently encountered in routine clinical practice. Hence, there is a need for more elaborate studies of mediastinal lesions to make the pathologists and clinicians aware of the large spectrum of these lesions. The present study describes the histomorphological spectrum of various mediastinal lesions in a tertiary care hospital in India, along with the discussion of some unusual and interesting cases. Considering the limited diagnostic material obtained in guided biopsies, the adequacy of such tissue for providing a definite opinion was also evaluated...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28255615/mechanism-of-icu-acquired-weakness-muscle-contractility-in-critical-illness
#20
EDITORIAL
Jane Batt, Sunita Mathur, Hans D Katzberg
No abstract text is available yet for this article.
March 3, 2017: Intensive Care Medicine
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