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https://www.readbyqxmd.com/read/29037512/treatment-outcomes-and-associated-factors-among-extremely-preterm-infants-in-a-major-children-hospital-in-guangxi-china
#1
Yan Li, Qiu-Fen Wei, Dan-Hua Meng, Xin-Nian Pan, Yan Mo, Li-Ping Yao, Lian-Fang Jing, Dan Zhao, Kai-Yan Shen, Jing Xu
BACKGROUND: In developing countries, infant survival rate and long-term outcomes of extremely preterm infants(EPIs) have significantly improved due to advances in perinatal care. The striking gap in the treatment outcome of EPIs between China and the other developed countries was a major concern. To assess treatment outcomes and associated factors among EPIs in Nanning, China. METHODS: This was a perspective study consisting of eligible cases with gestational age between 22 and 28 weeks and infants were followed to 18-24 months of age...
September 25, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29026981/a-clinical-scoring-system-to-predict-the-development-of-intraventricular-hemorrhage-ivh-in-premature-infants
#2
Yesim Coskun, Semra Isik, Tevfik Bayram, Kamran Urgun, Sibel Sakarya, Ipek Akman
OBJECTıVE: The aim of this study is to develop a scoring system for the prediction of intraventricular hemorrhage (IVH) in preterm infants in the first 7 days of life. METHODS: A prospective, clinical study was conducted in Bahcesehir University, Medical Park Goztepe Hospital Neonatal Intensive Care Unit, with the enrollment of 144 preterm infants with gestational age between 24 and 34 weeks. All preterms were followed up for IVH after birth until the 4th week of life. The demographic characteristics and clinical risk factors were noted...
October 12, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28989043/cerebrospinal-fluid-leak-at-percutaneous-exit-of-ventricular-catheter-as-crucial-risk-factor-for-external-ventricular-drainage-related-infection-in-adult-neurosurgical-patients
#3
Jaechan Park, Yeon-Ju Choi, Boram Ohk, Hyun-Ha Chang
OBJECTIVE: The placement of a ventricular catheter for temporary cerebrospinal fluid (CSF) diversion is associated with a considerable risk of CSF infection. The authors investigated the effect of a CSF leak on CSF-related infection and the predisposing factors for a CSF leak. METHODS: Fifty-two patients who underwent external ventricular drainage (EVD) for acute hydrocephalus associated with a subarachnoid hemorrhage (SAH) or intraventricular hemorrhage (IVH) were enrolled in this prospective study...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28988158/outcomes-of-oxygen-saturation-targeting-during-delivery-room-stabilisation-of-preterm-infants
#4
Ju Lee Oei, Neil N Finer, Ola Didrik Saugstad, Ian M Wright, Yacov Rabi, William Tarnow-Mordi, Wade Rich, Vishal Kapadia, Denise Rook, John P Smyth, Kei Lui, Maximo Vento
OBJECTIVE: To determine the association between SpO2 at 5 min and preterm infant outcomes. DESIGN: Data from 768 infants <32 weeks gestation from 8 randomised controlled trials (RCTs) of lower (≤0.3) versus higher (≥0.6) initial inspiratory fractions of oxygen (FiO2) for resuscitation, were examined. SETTING: Individual patient analysis of 8 RCTs INTERVENTIONS: Lower (≤0.3) versus higher (≥0.6) oxygen resuscitation strategies targeted to specific predefined SpO2 before 10 min of age...
October 7, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28986579/outcomes-of-23-and-24-weeks-gestation-infants-in-wellington-new-zealand-a-single-centre-experience
#5
Mary Judith Berry, Maria Saito-Benz, Clint Gray, Rebecca Maree Dyson, Paula Dellabarca, Stefan Ebmeier, David Foley, Dawn Elizabeth Elder, Vaughan Francis Richardson
Optimal perinatal care of infants born less than 24 weeks gestation remains contentious due to uncertainty about the long-term neurodevelopment of resuscitated infants. Our aim was to determine the short-term mortality and major morbidity outcomes from a cohort of inborn infants born at 23 and 24 weeks gestation and to assess if these parameters differed significantly between infants born at 23 vs. 24 weeks gestation. We report survival rates at 2-year follow-up of 22/38 (58%) at 23 weeks gestation and 36/60 (60%) at 24 weeks gestation...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28979727/early-predictors-of-neonatal-intraventricular-hemorrhage
#6
Mohamed Shawky Elfarargy, Mohamed Adel Eltomey, Neama Ali Soliman
OBJECTIVE: Current study aimed toward the early prediction of neonatal intraventricular hemorrhage (IVH) for better management and prognosis. METHODS: This prospective study was conducted on forty neonates at the Neonatal Intensive Care Unit of Pediatrics and Medical Biochemistry department (Tanta University, Egypt) from July 2016 to June 2017. Cord blood erythropoietin and venous blood Activin A were assayed within the first hour of life. Neonates were divided into 2 groups: Group 1 (with IVH) included twenty neonates who developed IVH proved by transcranial ultrasonography (u/s) and Group 2 (without IVH) included twenty neonates who were admitted to the NICU but did not develop IVH, also proved by transcranial u/s...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28977011/thrombocytopenia-in-neonatal-sepsis-incidence-severity-and-risk-factors
#7
Isabelle M C Ree, Suzanne F Fustolo-Gunnink, Vincent Bekker, Karin J Fijnvandraat, Sylke J Steggerda, Enrico Lopriore
OBJECTIVES: Thrombocytopenia is a frequent problem in neonatal sepsis and is among the most predictive, independent risk factors for sepsis-associated mortality. This study aims to clarify the occurrence, severity and duration of thrombocytopenia in neonatal sepsis. STUDY DESIGN: A cohort study was carried out among all neonates with proven culture positive sepsis that were admitted to a tertiary NICU between 2006 and 2015 (n = 460). The occurrence, severity and duration of thrombocytopenia were recorded, as well as major bleedings and potential risk factors for mortality in neonatal sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/28975005/safety-of-intraventricular-rt-pa-for-pan-ventricular-ivh-caused-by-a-ruptured-avm-a-case-report
#8
Sushrut Dharmadhikari, Ashutosh Mahapatra, Anita Tipirneni, Dileep Yavagal, Amer M Malik
Intraventricular recombinant tissue plasminogen activator (IVT rt-PA) has improved outcomes for intraventricular hemorrhage (IVH). Patients with suspected or untreated arteriovenous malformations (AVMs) have been excluded from clinical trials. We present a patient with IVH secondary to a ruptured AVM safely treated with IVT rt-PA. A 48-year-old Hispanic male with a history of dermatomyositis presented to the emergency department with sudden left-sided weakness. En route to computed tomography (CT), he became lethargic...
October 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28973194/shunt-dependent-hydrocephalus-after-aneurysmal-subarachnoid-hemorrhage-predictors-and-long-term-functional-outcomes
#9
Gabriella M Paisan, Dale Ding, Robert M Starke, R Webster Crowley, Kenneth C Liu
BACKGROUND: Although chronic hydrocephalus requiring shunt placement is a known sequela of aneurysmal subarachnoid hemorrhage (aSAH), its effect on long-term functional outcomes is incompletely understood. OBJECTIVE: To identify predictors of shunt-dependent hydrocephalus and shunt complications after aSAH and determine the effect of shunt dependence on functional outcomes in aSAH patients. METHODS: We evaluated a database of patients treated for aSAH at a single center from 2000 to 2015...
July 31, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28959481/brain-iron-overload-following-intracranial-haemorrhage
#10
REVIEW
Thomas Garton, Richard F Keep, Ya Hua, Guohua Xi
Intracranial haemorrhages, including intracerebral haemorrhage (ICH), intraventricular haemorrhage (IVH) and subarachnoid haemorrhage (SAH), are leading causes of morbidity and mortality worldwide. In addition, haemorrhage contributes to tissue damage in traumatic brain injury (TBI). To date, efforts to treat the long-term consequences of cerebral haemorrhage have been unsatisfactory. Incident rates and mortality have not showed significant improvement in recent years. In terms of secondary damage following haemorrhage, it is becoming increasingly apparent that blood components are of integral importance, with haemoglobin-derived iron playing a major role...
December 2016: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28956133/the-effects-of-mild-germinal-matrix-intraventricular-haemorrhage-on-the-developmental-white-matter-microstructure-of-preterm-neonates-a-dti-study
#11
Domenico Tortora, Carola Martinetti, Mariasavina Severino, Sara Uccella, Mariya Malova, Alessandro Parodi, Fabia Brera, Giovanni Morana, Luca Antonio Ramenghi, Andrea Rossi
OBJECTIVES: To evaluate white matter (WM) microstructural changes in preterm neonates (PN) with mild germinal matrix-intraventricular haemorrhage (mGMH-IVH) (grades I and II) and no other associated MRI abnormalities, and correlate them with gestational age (GA) and neurodevelopmental outcome. METHODS: Tract-based spatial-statistics (TBSS) was performed on DTI of 103 patients studied at term-equivalent age, to compare diffusional parameters (fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)) between mGMH-IVH neonates (24/103) and controls matched by GA at birth and sex...
September 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28949275/assessment-of-cerebrovascular-development-and-intraventricular-hemorrhages-in-preterm-infants-with-optical-measures-of-the-brain-arterial-pulse-wave
#12
Antonio M Chiarelli, Mahdi Mahmoudzadeh, Kathy A Low, Edward L Maclin, Guy Kongolo, Sabrina Goudjil, Monica Fabiani, Fabrice Wallois, Gabriele Gratton
Preterm infants (born at 24-34 weeks of gestational age) suffer from a high incidence of neurological complications. Cerebrovascular lesions (intraventricular hemorrhages, IVH, and ischemic injury) due to the immaturity of the vascular system and its inability to adapt to the extra-uterine environment are the major causes of adverse neurological outcomes. We investigated the feasibility of assessing cerebrovascular status in preterm infants using a novel non-invasive optical procedure, pulse-DOT, usable within the incubator...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28932408/golden-hour-of-neonatal-life-need-of-the-hour
#13
REVIEW
Deepak Sharma
"Golden Hour" of neonatal life is defined as the first hour of post-natal life in both preterm and term neonates. This concept in neonatology has been adopted from adult trauma where the initial first hour of trauma management is considered as golden hour. The "Golden hour" concept includes practicing all the evidence based intervention for term and preterm neonates, in the initial sixty minutes of postnatal life for better long-term outcome. Although the current evidence supports the concept of golden hour in preterm and still there is no evidence seeking the benefit of golden hour approach in term neonates, but neonatologist around the globe feel the importance of golden hour concept equally in both preterm and term neonates...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28923985/randomised-trial-of-cord-clamping-and-initial-stabilisation-at-very-preterm-birth
#14
Lelia Duley, Jon Dorling, Angela Pushpa-Rajah, Sam J Oddie, Charles William Yoxall, Bernard Schoonakker, Lucy Bradshaw, Eleanor J Mitchell, Joe Anthony Fawke
OBJECTIVES: For very preterm births, to compare alternative policies for umbilical cord clamping and immediate neonatal care. DESIGN: Parallel group randomised (1:1) trial, using sealed opaque numbered envelopes. SETTING: Eight UK tertiary maternity units. PARTICIPANTS: 261 women expected to have a live birth before 32 weeks, and their 276 babies. INTERVENTIONS: Cord clamping after at least 2 min and immediate neonatal care with cord intact, or clamping within 20 s and immediate neonatal care after clamping...
September 18, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28921813/what-is-the-safest-mode-of-birth-for-extremely-preterm-breech-singleton-infants-who-are-actively-resuscitated-a-systematic-review-and-meta-analyses
#15
Marinela Grabovac, Jehan N Karim, Tetsuya Isayama, Sugee Korale Liyanage, Sarah D McDonald
BACKGROUND: The safest delivery mode of extremely preterm breech singletons is unknown. OBJECTIVES: To determine safest delivery mode of actively resuscitated extremely preterm breech singletons. SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and ClinicalTrials. gov from 1994-May 2017. SELECTION CRITERIA: We included studies comparing outcomes by delivery mode in actively resuscitated breech infants between 23(+0) -27(+6) weeks...
September 18, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28920538/fibrinolytic-for-treatment-of-intraventricular-hemorrhage-a-meta-analysis-and-systematic-review
#16
Alexandra Delaney Baker, Krissia Margarita Rivera Perla, Zhiyuan Yu, Rachel Dlugash, Radhika Avadhani, William Andrew Mould, Wendy Ziai, Richard E Thompson, Dimitre Staykov, Daniel F Hanley
Background Intraventricular hemorrhage is a significant cause of mortality and morbidity worldwide. Treating intraventricular hemorrhage with intraventricular fibrinolytic therapy via a catheter is becoming an increasingly utilized intervention. Aims This meta-analysis aimed to investigate the role of intraventricular fibrinolytic treatment in hypertensive intraventricular hemorrhage patients and evaluate the effect sizes for survival as well as level of function at differing time points. Summary of review PubMed, CNKI, VIP, and Wanfang were searched using the terms "IVH" and "IVH and ICH" for human studies with adult patients published between January 1950 and July 2016...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28916575/effects-of-probiotics-on-necrotizing-enterocolitis-sepsis-intraventricular-hemorrhage-mortality-length-of-hospital-stay-and-weight-gain-in-very-preterm-infants-a-meta-analysis
#17
REVIEW
Jing Sun, Gayatri Marwah, Matthew Westgarth, Nicholas Buys, David Ellwood, Peter H Gray
Probiotics are increasingly used as a supplement to prevent adverse health outcomes in preterm infants. We conducted a systematic review, meta-analysis, and subgroup analysis of findings from randomized controlled trials (RCTs) to assess the magnitude of the effect of the probiotics on health outcomes among very-low-birth-weight (VLBW) infants. Relevant articles from January 2003 to June 2017 were selected from a broad range of databases, including Medline, PubMed, Scopus, and Embase. Studies were included if they used an RCT design, involved a VLBW infant (birthweight <1500 g or gestational age <32 wk) population, included a probiotic intervention group, measured necrotizing enterocolitis (NEC) as a primary outcome, and measured sepsis, mortality, length of hospital stay, weight gain, and intraventricular hemorrhage (IVH) as additional outcomes...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28901997/risk-factors-associated-with-intraventricular-hemorrhage-in-extremely-premature-neonates
#18
Jonathan C Roberts, M Jawad Javed, James R Hocker, Huaping Wang, Michael D Tarantino
: Intraventricular hemorrhage (IVH) is a significant cause of morbidity in extremely premature infants despite many advances in neonatal intensive care. We conducted an institutional retrospective review aimed to correlate risk factors associated with IVH. Clinical variables reported to the Vermont-Oxford Network on less than 30 weeks gestational age infants over a 5-year period were evaluated with Pearson's chi-square and multivariate logistic regression. Of 618 infants born less than 30-week gestational age, 178 (28...
September 8, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28899830/simple-lateral-suboccipital-approach-and-modification-for-vertebral-artery-aneurysms-a-study-of-52-cases-over-10-years
#19
Mardjono Tjahjadi, Behnam Rezai-Jahromi, Joseph Serrone, Ville Nurminen, Joham Choque-Velasquez, Riku Kivisaari, Hanna Lehto, Mika Niemelä, Juha Hernesniemi
INTRODUCTION: Complex skull base approaches are frequently used to treat intracranial vertebral artery (VA) and proximal posterior inferior cerebellar artery (PICA) aneurysms. These complex procedures are associated with higher risk of neurovascular injury. Hence, a less invasive surgical approach is needed to improve treatment's efficacy and safety. MATERIAL AND METHODS: A retrospective analysis was conducted on clinical and radiological data from surgeries where simple lateral suboccipital and "lateral enough" approaches were used to clip VA aneurysms in the Department of Neurosurgery at Helsinki University Central Hospital from 2000 - 2009...
September 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28892716/neuroscience-step-down-unit-admission-criteria-for-patients-with-intracerebral-hemorrhage
#20
Ayham M Alkhachroum, Oladi Bentho, Neel Chari, Ashish Kulhari, Wei Xiong
OBJECTIVES: The goal of our study is to determine optimal criteria which can be used to avoid admission to neuroscience intensive care units for patients with intracerebral hemorrhage (ICH). PATIENTS AND METHODS: This is a retrospective cohort study of 431 patients with primary ICH from January 2013 to the end of December 2015 and reviewed multiple admitting characteristics. Based on these needs, we tested the following step-down unit admission criteria: Supratentorial ICH, ICH volume <20 cc, no Intraventricular hemorrhage (IVH), systolic BP <200mmHg, no respiratory failure, GCS≥12...
September 5, 2017: Clinical Neurology and Neurosurgery
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