Andrew T Hale, Hunter Boudreau, Rishi Devulapalli, Phan Q Duy, Travis J Atchley, Michael C Dewan, Mubeen Goolam, Graham Fieggen, Heather L Spader, Anastasia A Smith, Jeffrey P Blount, James M Johnston, Brandon G Rocque, Curtis J Rozzelle, Zechen Chong, Jennifer M Strahle, Steven J Schiff, Kristopher T Kahle
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic syndromes as well as a secondary consequence of brain injury (intraventricular hemorrhage (IVH), infection, etc.) that can present across the age spectrum, highlighting the phenotypic heterogeneity of the disease. Surgical treatments include ventricular shunting and endoscopic third ventriculostomy with or without choroid plexus cauterization, both of which are prone to failure, and no effective pharmacologic treatments for HC have been developed...
March 4, 2024: Fluids and Barriers of the CNS