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Acute kidney injury

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https://www.readbyqxmd.com/read/29929186/increased-fatty-acid-oxidation-in-differentiated-proximal-tubular-cells-surviving-a-reversible-episode-of-acute-kidney-injury
#1
Aurélien Bataille, Pierre Galichon, Nadjim Chelghoum, Badreddine Mohand Oumoussa, Marie-Julia Ziliotis, Iman Sadia, Sophie Vandermeersch, Noémie Simon-Tillaux, David Legouis, Raphaël Cohen, Yi-Chun Xu-Dubois, Morgane Commereuc, Eric Rondeau, Stéphane Le Crom, Alexandre Hertig
BACKGROUND/AIMS: Fatty acid oxidation (FAO), the main source of energy produced by tubular epithelial cells in the kidney, was found to be defective in tubulo-interstitial samples dissected out in kidney biopsies from patients with chronic kidney disease (CKD). Experimental data indicated that this decrease was a strong determinant of renal fibrogenesis, hence a focus for therapeutic interventions. Nevertheless, whether persistently differentiated renal tubules, surviving in a pro-fibrotic environment, also suffer from a decrease in FAO, is currently unknown...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29928645/bile-cast-nephropathy-the-unknown-dangers-of-online-shopping
#2
Andrea Fisler, Tobias Breidthardt, Nadine Schmidlin, Helmut Hopfer, Michael Dickenmann, Katrin König, Patricia Hirt-Minkowski
Renal dysfunction in the setting of cholestatic liver disease is multifactorial but most often due to decreased kidney perfusion from intravascular volume depletion, acute tubular injury/necrosis, and hepatorenal syndrome. Drug-induced hepatotoxicity may be associated with a cholestatic injury pattern. We report a case of a 56-year-old man with a diagnosis of bile cast nephropathy, as a complication of drug-induced severe hyperbilirubinemia due to the abuse of intramuscular anabolic steroids bought on the internet to increase muscular mass for bodybuilding training...
May 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29927987/u-shape-association-of-serum-albumin-level-and-acute-kidney-injury-risk-in-hospitalized-patients
#3
Charat Thongprayoon, Wisit Cheungpasitporn, Michael A Mao, Ankit Sakhuja, Kianoush Kashani
BACKGROUND: While an association between hypoalbuminemia and increased risk of acute kidney injury (AKI) is well-established, the risk of AKI development and its severity among patients with elevated serum albumin is unclear. The aim of this study was to evaluate the risk of AKI in hospitalized patients stratified by various admission serum albumin levels. METHODS: This single-center retrospective study was conducted at a tertiary referral hospital. All adult hospitalized patients who had admission albumin levels available between January 2009 and December 2013 were enrolled...
2018: PloS One
https://www.readbyqxmd.com/read/29926539/body-mass-index-as-a-predictor-of-acute-kidney-injury-in-critically-ill-patients-a-retrospective-single-center-study
#4
Sunmi Ju, Tae Won Lee, Jung Wan Yoo, Seung Jun Lee, Yu Ji Cho, Yi Yeong Jeong, Jong Deog Lee, Ju Young Kim, Gi Dong Lee, Ho Cheol Kim
BACKGROUND: The aim of this study was to examine the influence of body mass index (BMI) on the development of acute kidney injury (AKI) in critically ill patients in intensive care unit (ICU). METHODS: Data of patients admitted to medical ICU from December 2011 to May 2014 were retrospectively analyzed. Patients were classified into three groups according to their BMI: underweight (<18.5 kg/m²), normal (18.5-24.9 kg/m²), and overweight (≥25 kg/m²). The incidence of AKI was compared among these groups and factors associated with the development of AKI were analyzed...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29925813/does-the-automatic-measurement-of-interleukin-6-allow-for-prediction-of-complications-during-the-first-48-h-of-acute-pancreatitis
#5
Witold Kolber, Paulina Dumnicka, Małgorzata Maraj, Beata Kuśnierz-Cabala, Piotr Ceranowicz, Michał Pędziwiatr, Barbara Maziarz, Małgorzata Mazur-Laskowska, Marek Kuźniewski, Mateusz Sporek, Jerzy Walocha
Acute pancreatitis (AP) in most patients takes a course of self-limiting local inflammation. However, up to 20% of patients develop severe AP (SAP), associated with systemic inflammation and/or pancreatic necrosis. Early prediction of SAP allows for the appropriate intensive treatment of severe cases, which reduces mortality. Serum interleukin-6 (IL-6) has been proposed as a biomarker to assist early diagnosis of SAP, however, most data come from studies utilizing IL-6 measurements with ELISA. Our aim was to verify the diagnostic usefulness of IL-6 for the prediction of SAP, organ failure, and need for intensive care in the course of AP using a fully automated assay...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29925558/case-of-severe-acute-lupus-myocarditis-and-multiple-organ-failure
#6
Aaron M Hawkins, Lalith S B Jesuthasan, Deepak L Vardesh
We report a case of severe lupus myocarditis with rapid, acute deterioration to cardiogenic shock and multiorgan failure, highlighting the importance of early identification and treatment of acute presentations in patients with systemic lupus erythematosus. A 31-year-old woman with previously diagnosed subacute cutaneous lupus erythematosus initially presented with abdominal pain and frank per-rectal bleeding. She deteriorated rapidly with type 1 respiratory failure and acute kidney injury requiring dialysis secondary to acute cardiac failure with a prolonged intensive care unit admission, over a month...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29925073/novel-proinflammatory-function-of-renal-intercalated-cells
#7
Sylvie Breton, Dennis Brown
BACKGROUND: Serious and often fatal acute kidney injury (AKI) is frequently seen after major surgery, local and remote organ damage, and sepsis. It is associated with uncontrolled inflammation, and is usually diagnosed only after the kidneys have gone through significant and often irreversible damage. SUMMARY: During our work involving another type of kidney disease that leads to acid-base disorders of the blood, we unexpectedly found high levels of a protein called the P2Y14 "purinergic" receptor, in specialized kidney epithelial cells called intercalated cells (ICs)...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29924949/case-19-2018-a-15-year-old-girl-with-acute-kidney-injury
#8
Ann Y Kao, Pallavi Sagar, Jean E Klig, Amita Sharma, Kristen J Tomaszewski
New England Journal of Medicine, Volume 378, Issue 25, Page 2421-2429, June 2018.
June 21, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29924305/telocytes-promote-vegf-expression-and-alleviate-ventilator-induced-lung-injury-in-mice
#9
Ruihua Ma, Pinwen Wu, Qiqing Shi, Dongli Song, Hao Fang
Mechanical ventilation (MV) is an important procedure for the treatment of patients with acute lung injury or acute respiratory distress syndrome in a clinical setting; however, MV can lead to severe complications, including ventilator-induced lung injury (VILI). Telocytes (TCs) can promote tissue repair following injury in the heart, kidneys, and other organs. The aim of this study was to investigate the role of TCs in VILI in mice and the associated mechanisms. By using in vivo studies in mice and in vitro studies in cells, we demonstrated that an airway injection of TCs can reduce the pulmonary inflammatory response and improve the lung function in mice with VILI and promote the proliferation of pulmonary vascular endothelial cells...
June 19, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29923951/lack-of-association-between-levels-and-length-of-intraoperative-controlled-hypotension-and-acute-kidney-injury-in-total-hip-arthroplasty-patients-receiving-neuraxial-anesthesia
#10
Sarah M Weinstein, Jacques T YaDeau, Stavros G Memtsoudis
BACKGROUND AND OBJECTIVES: Previous research suggests that increased duration and lower levels of intraoperative hypotension (IOH) are associated with postoperative acute kidney injury (AKI). However, this association has not been evaluated in the context of intraoperative controlled hypotension (IOCH), a practice that has been linked in the past to improved outcomes with respect to blood loss and transfusion needs. This study aimed to investigate whether IOCH is associated with postoperative AKI among total hip arthroplasty patients at an institution where this technique is commonly practiced...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29923765/physiological-functions-of-ferroportin-in-the-regulation-of-renal-iron-recycling-and-ischemic-acute-kidney-injury
#11
Xueqiao Wang, Xiaoqing Zheng, Juanlian Zhang, Shifeng Zhao, Zhigang Wang, Fudi Wang, Wenjun Shang, Jonathan Barasch, Andong Qiu
Renal iron recycling preserves the filtered iron from urinary excretion. However, it remains debated whether ferroportin (FPN), the solely known iron exporter, is functionally involved in renal iron recycling, and whether renal iron recycling is required for systemic iron homeostasis. We deleted FPN in the whole nephrons using a Nestin-Cre and in the distal nephrons and collecting ducts using a Ksp-Cre, and investigated its impacts on renal iron recycling and systemic iron homeostasis. FPN deletion by Nestin-Cre but not by Ksp-Cre caused excess iron retention and increased ferritin heavy chain (FTH1) specifically in the proximal tubules, and resulted in the reduction of serum and hepatic iron...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923218/inhibition-of-maternally-expressed-gene-3-attenuated-lipopolysaccharide-induced-apoptosis-through-sponging-mir-21-in-renal-tubular-epithelial-cells
#12
Ru Yang, Suxuan Liu, Jian Wen, Leixi Xue, Yi Zhang, Dong Yan, Guokun Wang, Zhichun Liu
Acute kidney injury (AKI) results in retention of waste products and dysregulation of extracellular volume and electrolytes, thus leading to a variety of complications. Recent advances in long noncoding RNAs suggested their close relationship with disease progression. In the current study, we investigated the role and mechanism of maternally expressed gene 3 (MEG3) on AKI pathogenesis. Real-time polymerase chain reaction found that the expression of MEG3 was significantly increased in both kidney tissues and TKPTS cells induced by lipopolysaccharide (LPS)...
June 20, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29921994/response-to-letter-risk-factors-for-acute-kidney-injury-after-cardiopulmonary-bypass-by-rik-h-j-hendrix-et-al
#13
Richard F Newland, Robert A Baker
No abstract text is available yet for this article.
June 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29921993/risk-factors-for-acute-kidney-injury-after-cardiopulmonary-bypass
#14
Rik H J Hendrix, Yuri M Ganushchak, Patrick W Weerwind
No abstract text is available yet for this article.
June 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29921512/a-phase-ii-evaluation-of-sunitinib-in-the-treatment-of-persistent-or-recurrent-clear-cell-ovarian-carcinoma-an-nrg-oncology-gynecologic-oncology-group-study-gog-254
#15
John K Chan, William Brady, Bradley J Monk, Jubilee Brown, Mark S Shahin, Peter G Rose, Jae-Hoon Kim, Angeles Alvarez Secord, Joan L Walker, David M Gershenson
OBJECTIVES: To determine the efficacy and tolerability of sunitinib in recurrent or persistent clear cell ovarian cancer patients. METHODS: All patients had one or two prior regimens with measurable disease. Tumors were at least 50% clear cell histomorphology and negative for WT-1 antigen and estrogen receptor expression by immunohistochemistry. Sunitinib 50 mg per day for 4 weeks was administered in repeated 6-week cycles until disease progression or prohibitive toxicity...
June 16, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29920787/genotypes-associated-with-tacrolimus-pharmacokinetics-impact-clinical-outcomes-in-lung-transplant-recipients
#16
Daniel R Calabrese, Rebecca Florez, Katherine Dewey, Christine Hui, Dara Torgerson, Tiffany Chong, Hilary Faust, Raja Rajalingam, Steven R Hays, Jeff A Golden, Jasleen Kukreja, Jonathan P Singer, John R Greenland
Most lung transplantation immunosuppression regimens include tacrolimus. Single nucleotide polymorphisms (SNPs) in genes important to tacrolimus bioavailability and clearance (ABCB1, CYP3A4 and CYP3A5) are associated with differences in tacrolimus pharmacokinetics. We hypothesized that polymorphisms in these genes would impact immunosuppression-related outcomes. We categorized ABCB1, CYP3A4, and CYP3A5 SNPs for 321 lung allograft recipients. Genotype effects on time to therapeutic tacrolimus level, interactions with antifungal medications, concentration to dose (C0 /D), acute kidney injury, and rejection were assessed using linear models adjusted for subject characteristics and repeat measures...
June 19, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29920466/association-between-extreme-temperature-and-kidney-disease-in-south-korea-2003-2013-stratified-by-sex-and-age-groups
#17
Ejin Kim, Ho Kim, Yong Chul Kim, Jung Pyo Lee
Weather conditions due to climate change affect the health directly and indirectly. Previous studies have shown associations with temperature, heat wave, and cold spell, and these do not only result in mortality from cardiovascular disease, respiratory disease, etc., but also in morbidity. This study aimed to quantify the relative risk for hospital admissions related to ambient temperature for genitourinary system diseases, which are representative of metabolic disease. We conducted a nationwide retrospective cohort study using claims data generated by medical services for diseases of the urinary system...
June 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29920283/rutin-a-quercetin-glycoside-alleviates-acute-endotoxemic-kidney-injury-in-c57bl-6-mice-via-suppression-of-inflammation-and-up-regulation-of-antioxidants-and-sirt1
#18
Mohammad-Reza Khajevand-Khazaei, Parvaneh Mohseni-Moghaddam, Marjan Hosseini, Leila Gholami, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Acute kidney injury (AKI) is a common complication following severe sepsis, its incidence is increasing, and it is associated with a high rate of morbidity and mortality. Rutin is a glycoside of the bioflavonoid quercetin with various protective effects due to its antioxidant and anti-inflammatory potential. In this research, we tried to assess the protective effect of rutin administration in a model of AKI in C57BL/6 mice. For induction of AKI, lipopolysaccharide (LPS) was injected once (10mg/kg, i.p.) and rutin was p...
June 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29917196/bml-111-inhibits-the-inflammatory-response-and-apoptosis-of-renal-tissue-in-rats-with-hemorrhagic-shock-by-inhibiting-the-mapk-pathway
#19
S-Y Chang, R-Q Sun, M Feng, Y-X Li, H-L Wang, Y-M Xu
OBJECTIVE: The effect of lipoxin receptor agonist BML-111 on acute kidney injury and AKI in rats with hemorrhagic shock (HS) and its mechanism were investigated. MATERIALS AND METHODS: A model of hemorrhagic shock in Sprague-Dawley (SD) rats was established, and recovered after 30 min of shock. 1 mg/kg BML-111 was intraperitoneally injected at the beginning of resuscitation in group BML-111. The concentration of serum creatinine, serum KIM-1 content, NGAL and inflammatory factors were detected...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916857/serum-lactate-level-accurately-predicts-mortality-in-critically-ill-patients-with-cirrhosis-with-acute-kidney-injury
#20
Dan-Qin Sun, Chen-Fei Zheng, Feng-Bin Lu, Sven Van Poucke, Xiao-Ming Chen, Yong-Ping Chen, Lai Zhang, Ming-Hua Zheng
BACKGROUND AND AIM: Serum lactate levels are routinely measured in critically ill patients with cirrhosis, and hyperlactatemia is a common finding, but its prognostic value remains controversial. Our aim was to examine whether serum lactate level could be used as a predictor of outcome in critically ill patients with cirrhosis (CICP) with acute kidney injury (AKI). PATIENTS AND METHODS: In this study, we included 480 consecutive patients with cirrhosis admitted to ICU, complicated with AKI, and were followed up for 365 days...
June 18, 2018: European Journal of Gastroenterology & Hepatology
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