Xuan Jiang, Fengyang Li, Jikun Mei, Tong Wu, Junhui Zhu, Ziheng Li, Zengshuai Wu, Hexiang Jiang, Na Li, Liancheng Lei
Although naturally Streptococcus suis serotype 2 (SS2) causes meningitis resulting in death or sequela of neurological symptoms in pigs and humans, severely threatening public health in the world, it has been difficult to build up and confirm experimental meningitis mouse models with obvious neurological syndrome for about two decades, which strongly hampers the in-depth study on the control measures and mechanisms of SS2-induced meningitis. In this study, a typical meningitis mouse model of SS2 was successfully established, as confirmed by the behavioral indicators of balance beam test, suspension test, and gait analysis...
April 16, 2024: Molecular Neurobiology