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https://www.readbyqxmd.com/read/29670546/-in-utero-exposure-to-maternal-diabetes-is-associated-with-early-abnormal-vascular-structure-in-offspring
#1
Abdallah Dib, Cyrielle Payen, Jennifer Bourreau, Mathilde Munier, Linda Grimaud, Ziad Fajloun, Laurent Loufrani, Daniel Henrion, Céline Fassot
Aim/hypothesis: In utero exposure to maternal diabetes increases the risk of developing hypertension and cardiovascular disorders during adulthood. We have previously shown that this is associated with changes in vascular tone in favor of a vasoconstrictor profile, which is involved in the development of hypertension. This excessive constrictor tone has also a strong impact on vascular structure. Our objective was to study the impact of in utero exposure to maternal diabetes on vascular structure and remodeling induced by chronic changes in hemodynamic parameters...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29660438/prenatal-nicotine-exposure-intergenerationally-programs-imperfect-articular-cartilage-via-histone-deacetylation-through-maternal-lineage
#2
Zhe Xie, Zhe Zhao, Xu Yang, Linguo Pei, Hanwen Luo, Qubo Ni, Bin Li, Yongjian Qi, Kai Tie, Jacques Magdalou, Liaobin Chen, Hui Wang
Accumulating evidence has shown that the impact of prenatal environmental factors on the organs of the offspring could last until the adulthood. Here, we aimed to investigate these effects and the potential mechanism of prenatal nicotine exposure (PNE) on the female adult cartilage of the first generation (PNE-F1) and the second generation (PNE-F2). Pregnant Wistar rats were injected with 2.0 mg/kg.d nicotine from gestational day (GD) 9 to 20. Then their F1 generation at GD20 and postnatal week (PW) 12, and F2 generation at PW12 were harvested...
April 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29659304/diet-induced-obesity-reduces-core-body-temperature-across-the-estrous-cycle-and-pregnancy-in-the-rat
#3
Rachael C Crew, Brendan J Waddell, Shane K Maloney, Peter J Mark
Obesity during pregnancy causes adverse maternal and fetal health outcomes and programs offspring for adult-onset diseases, including cardiovascular disease. Obesity also disrupts core body temperature (Tc ) regulation in nonpregnant rodents; however, it is unknown whether obesity alters normal maternal Tc adaptations to pregnancy. Since Tc is influenced by the circadian system, and both obesity and pregnancy alter circadian biology, it was hypothesized that obesity disrupts the normal rhythmic patterns of Tc before and during gestation...
April 16, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29658071/pathological-remodeling-of-the-myocardium-in-chronic-heart-failure-role-of-pgc-1%C3%AE
#4
T G Kulikova, O V Stepanova, A D Voronova, M P Valikhov, V N Sirotkin, I V Zhirov, S N Tereshchenko, V P Masenko, A N Samko, G T Sukhikh
Pathological remodeling of the myocardium in chronic heart failure includes the development of pathological cardiac hypertrophy, reactivation of the fetal genetic program, and disorders in cardiac energy metabolism. Coactivator-1α of receptor γ activated by peroxisome proliferator (PGC-1α), a transcription coactivator of nuclear receptors and metabolism master regulator, plays an important role in cardiac metabolism regulation. Studies on the animals models of chronic heart failure have demonstrated the development of pathological cardiac hypertrophy, metabolic disorders, and reactivation of the fetal genetic program; these processes are mutually related...
April 16, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29655963/abortion-training-in-us-obstetrics-and-gynecology-residency-programs
#5
Jody E Steinauer, Jema K Turk, Tali Pomerantz, Kristin Simonson, Lee A Learman, Uta Landy
BACKGROUND: Nearly 15 years ago, 51% of US obstetrics and gynecology residency training program directors reported that abortion training was routine, 39% reported training was optional, and 10% did not have training. The status of abortion training now is unknown. OBJECTIVE: To determine the current status of abortion training in obstetrics and gynecology residency programs. STUDY DESIGN: Through surveying program directors of US obstetrics and gynecology residency training programs, we conducted a cross-sectional study on the availability and characteristics of abortion training...
April 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29626983/hematopoietic-changes-in-the-offspring-induced-by-maternal-overweight-effect-on-placenta-and-fetal-liver-populations
#6
Luana Leirós, Juliana Barbosa Torreão Dáu, Daphne Pinheiro, Ana Carolina Stumbo Machado, Alessandra Alves Thole, Erika Afonso Costa Cortez, Laís de Carvalho, Simone Nunes de Carvalho
INTRODUCTION: Bone marrow cells (BMC) from obese adult mice display an increased apoptosis rate over proliferation. Hematopoietic stem cells (HSC) form all blood cells and are important BMC used in cell therapy. Because it is known that prenatal development can be affected by adverse metabolic epigenetic programming from the maternal organism, this work aimed to investigate the effects of maternal overweight on placenta and fetal liver hematopoietic niches. METHODS: Overweight was induced in female mice by overfeeding during lactation...
April 2018: Placenta
https://www.readbyqxmd.com/read/29626501/birth-weight-predicts-aging-trajectory-a-hypothesis
#7
REVIEW
Alexander M Vaiserman
Increasing evidence suggests that risk for age-related disease and longevity can be programmed early in life. In human populations, convincing evidence has been accumulated indicating that intrauterine growth restriction (IUGR) resulting in low birth weight (<2.5 kg) followed by postnatal catch-up growth is associated with various aspects of metabolic syndrome, type 2 diabetes and cardiovascular disease in adulthood. Fetal macrosomia (birth weight >4.5 kg), by contrast, is associated with high risk of non-diabetic obesity and cancers in later life...
April 4, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29618007/subphenotype-meta-analysis-of-testicular-cancer-genome-wide-association-study-data-suggests-a-role-for-rbfox-family-genes-in-cryptorchidism-susceptibility
#8
Yanping Wang, Dione R Gray, Alan K Robbins, Erin L Crowgey, Stephen J Chanock, Mark H Greene, Katherine A McGlynn, Katherine Nathanson, Clare Turnbull, Zhaoming Wang, Marcella Devoto, Julia Spencer Barthold
STUDY QUESTION: Can subphenotype analysis of genome-wide association study (GWAS) data from subjects with testicular germ cell tumor (TGCT) provide insight into cryptorchidism (undescended testis, UDT) susceptibility? SUMMARY ANSWER: Suggestive intragenic GWAS signals common to UDT, TGCT case-case and TGCT case-control analyses occur in genes encoding RBFOX RNA-binding proteins (RBPs) and their neurodevelopmental targets. WHAT IS KNOWN ALREADY: UDT is a strong risk factor for TGCT, but while genetic risk factors for TGCT are well-known, genetic susceptibility to UDT is poorly understood and appears to be more complex...
March 29, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29617878/role-of-tgf%C3%AE-signaling-in-maternal-ethanol-induced-fetal-articular-cartilage-dysplasia-and-adult-onset-of-osteoarthritis-in-male-rats
#9
Qubo Ni, Kaihang Lu, Jing Li, Yang Tan, Jun Qin, Jacques Magdalou, Liaobin Chen, Hui Wang
Background: Based on our previous findings that prenatal ethanol exposure in offspring increased susceptibility to adult osteoarthritis (OA), this study aimed to further investigate the direct toxicity of ethanol on fetal articular cartilage development. Methods: Rat bone marrow-derived stroma cells (BMSCs) were capsulated in alginate beads, incubated in a chondrogenic differentiation medium, and cultured for 4 weeks with ethanol treatment at concentrations of 0, 4, 20, and 100 mM...
March 29, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29616835/lessons-learned-from-the-implementation-of-non-invasive-fetal-rhd-screening
#10
Frederik Banch Clausen
In the fight against hemolytic disease of the fetus and newborn, pregnant RhD negative women are offered antenatal and postnatal anti-D immunoglobulin prophylaxis to prevent the development of antibodies against the fetal D antigen. Antenatal prophylaxis has traditionally been provided to all D negative pregnant women, as the fetal RhD type remains unknown until birth. With noninvasive prenatal testing of cell-free DNA, predicting the fetal RhD type has become highly feasible based on analysis of the fetal RHD gene...
April 19, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29614250/paternal-physical-exercise-demethylates-the-hippocampal-dna-of-male-pups-without-modifying-the-cognitive-and-physical-development
#11
Filipe Mega, André Luís Ferreira de Meireles, Francele Valente Piazza, Christiano Spindler, Ethiane Segabinazi, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Simone Marcuzzo
Maternal exercise is known to have beneficial effects in progeny development, but the influence of paternal exercise on the offspring still unclear. Since spermatogenesis is a continuous process, the father's life experiences can reprogram epigenetic content of the sperm and somehow interfere on offspring phenotype. This study was designed to evaluate the effects of paternal physical exercise on cognitive and physical development and on hippocampal DNA methylation levels of the offspring. Adult male Wistar rats were divided into two groups: sedentary and exercised...
March 31, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29609444/small-for-gestational-age-and-obesity-epidemiology-and-general-risks
#12
REVIEW
Hyo-Kyoung Nam, Kee-Hyoung Lee
Children born small for gestational age (SGA) have several life-long consequences. Previous epidemiological studies investigated from childhood to adulthood reported that a number of chronic diseases originate in the prenatal period. With the emerging era of obesity epidemic, more concerns are related to being obese than being short-statured in SGA children. The exact mechanisms are uncertain; however, growth hormone-insulin-like growth factor axis disturbance by fetal programming and accelerated postnatal weight gain contributed to central adiposity in SGA children...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29596946/genome-wide-dna-methylation-profiling-in-infants-born-to-gestational-diabetes-mellitus
#13
Xiaoling Weng, Fatao Liu, Hong Zhang, Mengyuan Kan, Ting Wang, Mingyue Dong, Yun Liu
BACKGROUND: Offspring exposed to gestational diabetes mellitus (GDM) are at a high risk for metabolic diseases. The mechanisms behind the association between offspring exposed to GDM in utero and an increased risk of health consequences later in life remain unclear. The aim of this study was to clarify the changes in methylation levels in the foetuses of women with GDM and to explore the possible mechanisms linking maternal GDM with a high risk of metabolic diseases in offspring later in life...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29594444/epidemiology-of-hip-fractures-systematic-literature-review-of-german-data-and-an-overview-of-the-international-literature
#14
REVIEW
Kilian Rapp, Gisela Büchele, Karsten Dreinhöfer, Benjamin Bücking, Clemens Becker, Petra Benzinger
BACKGROUND: Hip fractures are regarded as a worldwide epidemic and a major public health concern. Changing risk factors, local differences and temporal trends contribute to the particular epidemiology of hip fractures. This overview gives a comprehensive insight into the epidemiology of hip fractures and reviews where German data have contributed to the literature. METHODS: The review of the epidemiology of hip fractures in Germany is based on a systematic literature search in PubMed...
March 28, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29587658/de-medicalization-of-birth-by-reducing-the-use-of-oxytocin-for-augmentation-among-first-time-mothers-a-prospective-intervention-study
#15
L C Gaudernack, K F Frøslie, T M Michelsen, N Voldner, M Lukasse
BACKGROUND: The use of synthetic oxytocin for augmentation of labor is rapidly increasing worldwide. Hyper-stimulation is the most significant side effect, which may cause fetal distress and operative delivery. We performed an intervention consisting of an educational program and modified guidelines to achieve a more appropriate use of oxytocin. METHODS: This prospective intervention study included 431 first-time mothers at term with spontaneous onset of labor before (October 2012 to May 2013), and 664 after the intervention (April 2014 to April 2015)...
March 27, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29584590/maternal-thyroid-function-in-early-pregnancy-and-child-neurodevelopmental-disorders-a-danish-nationwide-case-cohort-study
#16
Stine Linding Andersen, Stig Andersen, Peter Vestergaard, Jørn Olsen
BACKGROUND: Maternal thyroid dysfunction may adversely affect fetal brain development, but more evidence is needed to refine this hypothesis. The aim of this study was to evaluate potential fetal programming by abnormal maternal thyroid function on child neurodevelopmental disorders. METHODS: The design was a case-cohort study within the Danish National Birth Cohort (1997-2003). From the eligible cohort of 71,706 women, a random 12% sub-cohort (n = 7624) was selected, and all women (n = 2276) whose child was diagnosed with seizures, specific developmental disorder (SDD), autism spectrum disorder (ASD), and/or attention-deficit/hyperactivity disorder (ADHD) up to December 31, 2010, were identified...
March 27, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29581212/study-protocol-for-a-self-controlled-cluster-randomised-trial-of-the-alert-program-to-improve-self-regulation-and-executive-function-in-australian-aboriginal-children-with-fetal-alcohol-spectrum-disorder
#17
Bree Wagner, James P Fitzpatrick, Trevor G Mazzucchelli, Martyn Symons, Heather Carmichael Olson, Tracy Jirikowic, Donna Cross, Edie Wright, Emma Adams, Maureen Carter, Kaashifah Bruce, Jane Latimer
INTRODUCTION: While research highlights the benefits of early diagnosis and intervention for children with fetal alcohol spectrum disorders (FASD), there are limited data documenting effective interventions for Australian children living in remote communities. METHODS AND ANALYSIS: This self-controlled cluster randomised trial is evaluating the effectiveness of an 8-week Alert Program school curriculum for improving self-regulation and executive function in children living in remote Australian Aboriginal communities...
March 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29577468/maternal-fetal-cross-talk-through-cell-free-fetal-dna-telomere-shortening-microchimerism-and-inflammation
#18
Shi-Bin Cheng, Sarah Davis, Surendra Sharma
There exists a strong correlation between unscheduled inflammation at the maternal-fetal interface and the continuum of pregnancy complications. In normal pregnancy, immunological tolerance is established to protect the semi-allogeneic fetus. There has been extensive research on how the immunity, endovascular trophoblast migration, and hormonal nexus are orchestrated during pregnancy at the maternal-fetal interface to program a normal pregnancy outcome. It is not clear what contributes to the plasticity of uterine immune tolerance, fetal survial, and long-term post-partum health of the mother and the offspring...
March 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29575979/importance-of-the-integrated-test-in-the-down-s-syndrome-screening-algorithm
#19
Drahomira Springer, Jaroslav Loucky, Pavel Tesner, David Cutka, David Stejskal, Vladimir Gregor, Tomas Zima
Objective In the Czech Republic, over 97% of all pregnant women undergo some type of antenatal screening for Down's syndrome. In about 95% of cases with a confirmed fetal chromosomal abnormality, the pregnancy is terminated. The most commonly used test is the first trimester combined test. We investigated the impact of implementing an integrated sequential test to improve the detection of Down's syndrome pregnancies. Methods Data on the incidence of congenital defects, number of births, and affected pregnancies terminated are recorded in the National Registry of Congenital Anomalies...
January 1, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29568109/mitochondrial-inefficiency-in-infants-born-to-overweight-african-american-mothers
#20
Manjusha Abraham, Christina A Collins, Scott Flewelling, Maraya Camazine, Alison Cahill, W Todd Cade, Jennifer G Duncan
BACKGROUND: Currently 20-35% of pregnant women are obese, posing a major health risk for mother and fetus. It is postulated that an abnormal maternal-fetal nutritional environment leads to adverse metabolic programming, resulting in altered substrate metabolism in the offspring and predisposing to risks of obesity and diabetes later in life. Data indicate that oocytes from overweight animals have abnormal mitochondria. We hypothesized that maternal obesity is associated with altered mitochondrial function in healthy neonatal offspring...
March 3, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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