keyword
MENU ▼
Read by QxMD icon Read
search

Fetal programing

keyword
https://www.readbyqxmd.com/read/29025051/integrating-behavioral-health-risk-assessment-into-centralized-intake-for-maternal-and-child-health-services
#1
Sarah Kye Price, D Crystal Coles, Tracey Wingold
Effectively promoting women's health during and around the time of pregnancy requires early, nonstigmatizing identification and assessment of behavioral health risks (such as depression, substance use, smoking, and interpersonal violence) combined with timely linkage to community support and specialized interventions. This article describes an integrated approach to behavioral health risk screening woven into a point of first contact with the health care delivery system: centralized intake for maternal and child health home visiting programs...
September 4, 2017: Health & Social Work
https://www.readbyqxmd.com/read/29025046/decreased-insulin-secretion-in-pregnant-rats-fed-a-low-protein-diet
#2
Haijun Gao, Eric Ho, Meena Balakrishnan, Vijay Yechoor, Chandra Yallampalli
Low protein (LP) diet during pregnancy leads to reduced plasma insulin levels in rodents, but the underlying mechanisms remain unclear. Glucose is the primary insulin secretagogue and enhanced glucose stimulated insulin secretion (GSIS) in beta cells contributes to compensation for insulin resistance and maintenance of glucose homeostasis during pregnancy. In this study we hypothesized that plasma insulin levels in pregnant rats fed LP diet is reduced due to disrupted GSIS of pancreatic islets. We first confirmed reduced plasma insulin levels, then investigated in vivo insulin secretion by glucose tolerance test and ex vivo GSIS of pancreatic islets in the presence of glucose at different doses, and KCl, glibenclamide and L-arginine...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29017990/healthy-beyond-pregnancy-a-web-based-intervention-to-improve-adherence-to-postpartum-care-randomized-controlled-feasibility-trial
#3
Katherine Park Himes, Heidi Donovan, Stephanie Wang, Carrie Weaver, Jillian Rae Grove, Francesca Lucia Facco
BACKGROUND: During the postpartum visit, health care providers address issues with short- and long-term implications for maternal and child health. Women with Medicaid insurance are less likely to return for a postpartum visit compared with women with private insurance. Behavioral economics acknowledges that people do not make exclusively rational choices, rather immediate gratification, cognitive and psychological biases, and social norms influence decision making. Drawing on insights from decision science, behavioral economists have examined how these biases can be modulated through carefully designed interventions...
October 10, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/29016491/expanding-prenatal-care-to-unauthorized-immigrant-women-and-the-effects-on-infant-health
#4
Jonas J Swartz, Jens Hainmueller, Duncan Lawrence, Maria I Rodriguez
OBJECTIVE: To measure the effect of access to prenatal care on unauthorized and low-income, new legal permanent resident immigrant women and their offspring. METHODS: We used a difference-in-differences design that leverages the staggered rollout of Emergency Medicaid Plus by county from 2008 to 2013 as a natural experiment to estimate the effect on health service utilization for women and health outcomes for their infants. Regular Medicaid pregnancies were used as an additional control in a triple difference design...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28990569/-history-of-the-thymus-from-an-accident-of-evolution-to-the-programming-of-immunological-self-tolerance
#5
Vincent Geenen
This synthesis presents the most important disruptions of conceptions about the thymus since its discovery in Antique Greece. For centuries, the thymus was considered as a vestigial organ, and its role in T-lymphocyte differentiation has been proposed only in the 1960's. Most recent studies attribute to the thymus an essential and unique role in the programming of central immunological self-tolerance. The basal mechanism implicated in this function is the transcription in thymic epithelium of genes encoding precursors of self-antigens...
June 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28985312/maternal-renovascular-hypertensive-rats-treatment-with-hydrogen-sulfide-increased-the-methylation-of-at1b-gene-in-offspring
#6
Qi Guo, Xiaohong Feng, Hongmei Xue, Xu Teng, Sheng Jin, Xiaocui Duan, Lin Xiao, Yuming Wu
BACKGROUND: A large number of studies have shown hypertension of offspring in adulthood is related to parental health during pregnancy. Hydrogen sulfide (H2S) could relax placental vasculature and improve intrauterine growth restriction. In the present study, we want to observe the effect of H2S on the fetal programming of renovascular hypertension, a rat model of secondary hypertension. METHODS: Renovascular hypertension was induced by 2-kidney-1-clip, their adult pups were used to evaluate basal blood pressure...
August 8, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28983923/the-highs-and-lows-of-programmed-cardiovascular-disease-by-developmental-hypoxia-studies-in-the-chicken-embryo
#7
N Itani, C E Salinas, M Villena, K L Skeffington, C Beck, E Villamor, C E Blanco, D A Giussani
It is now established that adverse conditions during pregnancy can trigger a fetal origin of cardiovascular dysfunction and/or increase the risk of heart disease in later life. Sub-optimal environmental conditions during early life that may promote the development of cardiovascular dysfunction in the offspring include alterations in fetal oxygenation and nutrition as well as fetal exposure to stress hormones, such as glucocorticoids. There has been growing interest in identifying the partial contributions of each of these stressors to programming of cardiovascular dysfunction...
October 5, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28981462/gh-igf-1-signaling-and-current-knowledge-of-epigenetics-a-review-and-considerations-on-possible-therapeutic-options
#8
REVIEW
Francisco Álvarez-Nava, Roberto Lanes
Epigenetic mechanisms play an important role in the regulation of the Growth Hormone- Insulin-like Growth Factor 1 (GH-IGF1) axis and in processes for controlling long bone growth, and carbohydrate and lipid metabolism. Improvement of methodologies that allow for the assessment of epigenetic regulation have contributed enormously to the understanding of GH action, but many questions still remain to be clarified. The reversible nature of epigenetic factors and, particularly, their role as mediators between the genome and the environment, make them viable therapeutic target candidates...
October 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28981118/overactive-type-2-cannabinoid-receptor-induces-meiosis-in-fetal-gonads-and-impairs-ovarian-reserve
#9
Emanuela De Domenico, Federica Todaro, Gabriele Rossi, Susanna Dolci, Raffaele Geremia, Pellegrino Rossi, Paola Grimaldi
Type 2 cannabinoid receptor (CB2R) has been proposed to promote in vitro meiotic entry of postnatal male germ cells and to maintain the temporal progression of spermatogenesis in vivo. However, no information is presently available on the role played by CB2R in male and female fetal gonads. Here we show that in vitro pharmacological stimulation with JWH133, a CB2R agonist, induced activation of the meiotic program in both male and female fetal gonads. Upon stimulation, gonocytes initiated the meiotic program but became arrested at early stages of prophase I, while oocytes showed an increased rate of meiotic entry and progression toward more advanced stage of meiosis...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28979893/prenatal-maternal-stress-and-the-risk-of-asthma-in-children
#10
REVIEW
Konstantinos Douros, Maria Moustaki, Sophia Tsabouri, Anna Papadopoulou, Marios Papadopoulos, Kostas N Priftis
Emerging evidence indicate that maternal prenatal stress (MPS) can result in a range of long-term adverse effects in the offspring. The underlying mechanism of MPS is not fully understood. However, its complexity is emphasized by the number of purportedly involved pathways namely, placental deregulated metabolism of maternal steroids, impaired maturation of fetal HPA axis, imbalanced efflux of commensal bacteria across the placenta, and skewed immune development toward Th2. Fetal programming probably exerts a pivotal role in the end result of the above pathways through the modulation of gene expression...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28979757/prevalence-of-domestic-violence-on-pregnant-women-and-maternal-and-neonatal-outcomes-in-bandar-abbas-iran
#11
Abdol Azim Nejatizade, Nasibeh Roozbeh, Asiyeh Pormehr Yabandeh, Fatemeh Dabiri, Azita Kamjoo, Arefeh Shahi
BACKGROUND: Pregnancy by itself, imposes great physical and psychological pressures on a person and consequently, coupled with other stressors such as violence, can have adverse effects on the fetus and mother. OBJECTIVE: To assess the prevalence of domestic violence in pregnant women and maternal and infants' outcomes. METHODS: This is a descriptive study using a questionnaire. Data were collected from 725 women who delivered their babies at Shariati Hospital in Bandar Abbas in the summer and autumn of 2013...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28978751/an-anti-glypican-3-cd3-bispecific-t-cell-redirecting-antibody-for-treatment-of-solid-tumors
#12
Takahiro Ishiguro, Yuji Sano, Shun-Ichiro Komatsu, Mika Kamata-Sakurai, Akihisa Kaneko, Yasuko Kinoshita, Hirotake Shiraiwa, Yumiko Azuma, Toshiaki Tsunenari, Yoko Kayukawa, Yukiko Sonobe, Natsuki Ono, Kiyoaki Sakata, Toshihiko Fujii, Yoko Miyazaki, Mizuho Noguchi, Mika Endo, Asako Harada, Werner Frings, Etsuko Fujii, Eitaro Nanba, Atsushi Narita, Akihisa Sakamoto, Tetsuya Wakabayashi, Hiroko Konishi, Hiroaki Segawa, Tomoyuki Igawa, Takashi Tsushima, Hironori Mutoh, Yukari Nishito, Mina Takahashi, Lorraine Stewart, Ehab ElGabry, Yoshiki Kawabe, Masaki Ishigai, Shuichi Chiba, Masahiro Aoki, Kunihiro Hattori, Junichi Nezu
Cancer care is being revolutionized by immunotherapies such as immune checkpoint inhibitors, engineered T cell transfer, and cell vaccines. The bispecific T cell-redirecting antibody (TRAB) is one such promising immunotherapy, which can redirect T cells to tumor cells by engaging CD3 on a T cell and an antigen on a tumor cell. Because T cells can be redirected to tumor cells regardless of the specificity of T cell receptors, TRAB is considered efficacious for less immunogenic tumors lacking enough neoantigens...
October 4, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28978515/late-gestation-maternal-dietary-methyl-donor-and-cofactor-supplementation-in-sheep-partially-reverses-protection-against-allergic-sensitization-by-iugr
#13
Amy L Wooldridge, Robert J Bischof, Hong Liu, Gary K Heinemann, Damien S Hunter, Lynne C Giles, Rebecca A Simmons, Yu-Chin Lien, Wenyun Lu, Joshua D Rabinowitz, Karen L Kind, Julie A Owens, Vicki L Clifton, Kathryn L Gatford
Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our previous work suggest restricted growth in utero (IUGR) is protective against allergic disease. The mechanisms are not clearly defined but reduced fetal abundance and altered metabolism of methyl donors are hypothesized as possible underlying mechanisms. We therefore examined whether late gestation maternal dietary methyl donor and co-factor supplementation of the placentally-restricted (PR) sheep pregnancy would reverse allergic protection in progeny...
October 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28977753/the-manitoba-youth-justice-program-empowering-and-supporting-fasd-affected-youth-in-conflict-with-the-law
#14
Sally Elizabeth Longstaffe, Albert Chudley, Mary Kate Harvie, Teresa Brown, Dan Neault, Trevor John Markesteyn
Fetal Alcohol Spectrum Disorder (FASD) describes a constellation of physical, cognitive, neurologic and behavioral impairments resulting from prenatal exposure to alcohol. FASD is recognized as being one of the largest causes of preventable brain injury in children. There had long been concerns that some youth in conflict with the law may be affected with FASD given repetitive patterns of offending and apparent lack of understanding of consequences of their actions. In 2004 funding was received from Justice Canada for a pilot project with a cross departmental steering committee working together to determine a best way of working across systems to provide FASD assessments to these youth...
October 4, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28971246/transfer-of-maternal-immunity-and-programming-of-the-newborn-immune-system
#15
REVIEW
Madeleine F Jennewein, Bahaa Abu-Raya, Yiwei Jiang, Galit Alter, Arnaud Marchant
As placental mammals, the pregnant women and the fetus have intense and prolonged interactions during gestation. There is increasing evidence that multiple molecular as well as cellular components originating in pregnant women are transferred to the fetus. The transfer of maternal antibodies has long been recognized as a central component of newborn immunity against pathogens. More recent studies indicate that inflammatory mediators, micronutrients, microbial products and maternal cells are transferred in utero and influence the fetal immune system...
October 2, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28966619/changes-in-t-cell-and-dendritic-cell-phenotype-from-mid-to-late-pregnancy-are-indicative-of-a-shift-from-immune-tolerance-to-immune-activation
#16
Nishel Mohan Shah, Anna A Herasimtschuk, Adriano Boasso, Adel Benlahrech, Dietmar Fuchs, Nesrina Imami, Mark R Johnson
During pregnancy, the mother allows the immunologically distinct fetoplacental unit to develop and grow. Opinions are divided as to whether this represents a state of fetal-specific tolerance or of a generalized suppression of the maternal immune system. We hypothesized that antigen-specific T cell responses are modulated by an inhibitory T cell phenotype and modified dendritic cell (DC) phenotype in a gestation-dependent manner. We analyzed changes in surface markers of peripheral blood T cells, ex vivo antigen-specific T cell responses, indoleamine 2,3-dioxygenase (IDO) activity (kynurenine/tryptophan ratio, KTR), plasma neopterin concentration, and the in vitro expression of progesterone-induced blocking factor (PIBF) in response to peripheral blood mononuclear cell culture with progesterone...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28962690/early-and-late-onset-preeclampsia-and-the-tissue-specific-epigenome-of-the-placenta-and-newborn
#17
Emilie M Herzog, Alex J Eggink, Sten P Willemsen, Roderick C Slieker, Kim P J Wijnands, Janine F Felix, Jun Chen, Andrew Stubbs, Peter J van der Spek, Joyce B van Meurs, Régine P M Steegers-Theunissen
INTRODUCTION: Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing maternal cardiovascular- and metabolic risk factors. We hypothesize that PE is associated with altered epigenetic programming of placental and fetal tissues and that these epigenetic changes might elucidate the increased cardiovascular- and metabolic disease susceptibility in PE offspring...
October 2017: Placenta
https://www.readbyqxmd.com/read/28951977/polycystic-ovary-syndrome-throughout-a-woman-s-life
#18
REVIEW
José Bellver, Luis Rodríguez-Tabernero, Ana Robles, Elkin Muñoz, Francisca Martínez, José Landeras, Juan García-Velasco, Juan Fontes, Mónica Álvarez, Claudio Álvarez, Belén Acevedo
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age...
September 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28950109/care-experiences-of-women-who-used-opioids-and-experienced-fetal-or-infant-loss
#19
Lisa F Scott, Carol Shieh, Rachel A Umoren, Teri Conard
OBJECTIVE: To explore care experiences of women who used prescription or illicit opioids and experienced fetal or infant loss. DESIGN: A qualitative, descriptive design with secondary data analysis. SETTING: The Fetal and Infant Mortality Review program in an urban Midwestern county in the United States. PARTICIPANTS: Eleven women with histories of prescription or illicit opioid use who experienced fetal or infant loss participated in the semistructured telephone or in-person interview portion of the mortality case review...
September 23, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28946057/xenotransplantation-as-a-model-for-human-testicular-development
#20
REVIEW
Marsida Hutka, Lee B Smith, Rod T Mitchell
The developing male reproductive system may be sensitive to disruption by a wide range of exogenous 'endocrine disruptors'. In-utero exposure to environmental chemicals and pharmaceuticals have been hypothesized to have an impact in the increasing incidence of male reproductive disorders. The vulnerability to adverse effects as a consequence of such exposures is elevated during a specific 'window of susceptibility' in fetal life referred to as the masculinisation programing window (MPW). Exposures that occur during prepuberty, such as chemotherapy treatment for cancer during childhood, may also affect future fertility...
September 13, 2017: Differentiation; Research in Biological Diversity
keyword
keyword
12797
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"