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https://www.readbyqxmd.com/read/28938108/cervical-arthroplasty-versus-anterior-cervical-fusion-for-symptomatic-adjacent-segment-disease-after-anterior-cervical-fusion-surgery-review-of-treatment-in-41-patients
#1
Sang-Bok Lee, Kyoung-Suok Cho
OBJECTIVE: The purpose of this study is to compare the efficacy and safety of anterior cervical discectomy and fusion (ACDF) and cervical total disc replacement (CTDR) as revision surgeries for symptomatic adjacent segment degeneration (ASD) in cases with previous ACDF. PATIENTS AND METHODS: Between 2010 and 2014, 41 patients with previous cervical fusion surgery underwent ACDF or CTDR for symptomatic ASD. Twenty-two patients in the ACDF group underwent 26 ACDFs, and 19 patients in the CTDR group underwent 25 arthroplasties for symptomatic ASD...
August 4, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28937877/changes-in-peripapillary-nerve-fiber-layer-thickness-after-adjuvant-stereotactic-radiotherapy-in-patients-with-neovascular-age-related-macular-degeneration
#2
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
PURPOSE: To evaluate the effect of stereotactic radiotherapy (SRT) in conjunction with intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) drugs on peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with neovascular age-related macular degeneration (nAMD). METHODS: This was a retrospective, observational case series of patients with nAMD, who underwent SRT and subsequently had at least 12 months of complete follow-up...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28935976/tgf-%C3%AE-1-suppresses-ccl3-4-expression-through-the-erk-signaling-pathway-and-inhibits-intervertebral-disc-degeneration-and-inflammation-related-pain-in-a-rat-model
#3
Jian Zhang, Zemin Li, Fan Chen, Hui Liu, Hua Wang, Xiang Li, Xianguo Liu, Jianru Wang, Zhaomin Zheng
The objective of this study was to investigate the regulatory effects of TGF-β1 on CCL3/4 expression and inflammation-related pain during intervertebral disc degeneration (IVDD). TGF-β1 and CCL3/4 expression patterns in different degenerative human nucleus pulposus (NP) tissues were measured by qPCR and immunohistochemistry (IHC), and the effects of TGF-β1 on CCL3/4 expression were measured by qPCR, ELISA and immunofluorescence. The roles of NF-κB and MAPK in TGF-β1-mediated CCL3/4 promoter activity were studied using siRNAs, western blotting and qPCR...
September 22, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28926646/vascular-hypoperfusion-in-acute-optic-neuritis-is-a-potentially-new-neurovascular-model-for-demyelinating-diseases
#4
Ta-Ching Chen, Chao-Yuan Yeh, Chao-Wen Lin, Chung-May Yang, Chang-Hao Yang, I-Hung Lin, Pao-Yang Chen, Jung-Yu Cheng, Fung-Rong Hu
PURPOSE: Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON). METHODS: This three-year cohort study was conducted from September 1 2012, to August 31, 2015. Two hundred and forty-one patients with non-glaucomatous acute optic neuropathy were screened, and 42 non-highly myopic patients who had suffered their first episode of unilaterally idiopathic AON were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28925497/the-feasibility-of-the-cd271-and-cd271-mesenchymal-stromal-cell-enrichment-toward-nucleus-pulposus-like-cells
#5
Katarzyna Jezierska-Wozniak, Monika Barczewska, Aleksandra Habich, Pawel Wojtacha, Wanda Badowska, Wojciech Maksymowicz, Joanna Wojtkiewicz
INTRODUCTION: Factors promoting nerve cell ingrowth are considered responsible for chronic back pain resulting from the intervertebral disc degeneration (IDD). One of the recent exploratory IDD treatments is stem cell transplantation therapy. The CD271 (low-affinity nerve growth factor receptor) has been identified as a marker of the most homogeneous mesenchymal stem cell (MSC) subset. It is capable of promoting differentiation along adipogenic, osteogenic and chondrogenic lineages and producing significantly higher levels of cytokines as compared to the total population of plastic adherence-mesenchymal stem cells (PA-MSCs)...
September 19, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28923094/high-magnitude-compression-accelerates-the-premature-senescence-of-nucleus-pulposus-cells-via-the-p38-mapk-ros-pathway
#6
Pei Li, Gang Hou, Ruijie Zhang, Yibo Gan, Yuan Xu, Lei Song, Qiang Zhou
BACKGROUND: Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this process. METHODS: Rat NP cells seeded in decalcified bone matrix were subjected to non-compression (control) or compression (2% or 20% deformation, 1.0 Hz, 6 hours/day). The reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) and the p38 MAPK inhibitor SB203580 were used to investigate the roles of the ROS and p38 MAPK pathway under high-magnitude compression...
September 18, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28917706/the-effects-of-needle-damage-on-annulus-fibrosus-micromechanics
#7
Claudio Vergari, Jessica C Mansfield, Daniel Chan, Andrew Clarke, Judith R Meakin, Peter C Winlove
Needle puncture of the intervertebral disc can initiate a mechanical and biochemical cascade leading to disc degeneration. Puncture's mechanical effects have been shown near the puncture site, mechanical effects should be observed far, relative to needle size, from the puncture site, given the disc-wide damage induced by the stab. The aim of this work was to quantify these far-field effects, and to observe the local structural damage provoked by the needle. Strips of cow tail annulus fibrosus underwent two consecutive mechanical loadings to 5% tensile strain; fifteen samples were punctured in a radial direction with a randomly assigned needle between the two loadings (needle gauges between 19 and 23)...
September 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28915718/the-pi3k-akt-pathway-a-critical-player-in-intervertebral-disc-degeneration
#8
REVIEW
Zhi-Hua Ouyang, Wen-Jun Wang, Yi-Guo Yan, Bing Wang, Guo-Hua Lv
Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a severe public health problem worldwide. Current therapy for IDD aims to alleviate the symptoms and does not target the underlying pathological alternations within the disc. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against IDD, which is attributed to increase of ECM content, prevention of cell apoptosis, facilitation of cell proliferation, induction or prevention of cell autophagy, alleviation of oxidative damage, and adaptation of hypoxic microenvironment...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915712/formation-function-and-exhaustion-of-notochordal-cytoplasmic-vacuoles-within-intervertebral-disc-current-understanding-and-speculation
#9
REVIEW
Feng Wang, Zeng-Xin Gao, Feng Cai, Arjun Sinkemani, Zhi-Yang Xie, Rui Shi, Ji-Nan Wei, Xiao-Tao Wu
Notochord nucleus pulposus cells are characteristic of containing abundant and giant cytoplasmic vacuoles. This review explores the embryonic formation, biological function, and postnatal exhaustion of notochord vacuoles, aiming to characterize the signal network transforming the vacuolated nucleus pulposus cells into the vacuole-less chondrocytic cells. Embryonically, the cytoplasmic vacuoles within vertebrate notochord originate from an evolutionarily conserved vacuolation process during neurulation, which may continue to provide mechanical and signal support in constructing a mammalian intervertebral disc...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912585/matrisome-profiling-during-intervertebral-disc-development-and-ageing
#10
Joana Caldeira, Cátia Santa, Hugo Osório, Maria Molinos, Bruno Manadas, Raquel Gonçalves, Mário Barbosa
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation. However, a thorough study of ECM profiling is needed, to better understand IVD development and age-associated degeneration. As so, iTRAQ LC-MS/MS analysis of foetus, young and old bovine NPs, was performed to define the NP matrisome...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910701/biomechanical-analysis-of-lumbar-decompression-surgery-in-relation-to-degenerative-changes-in-the-lumbar-spine-validated-finite-element-analysis
#11
Quan You Li, Ho-Joong Kim, Juhyun Son, Kyoung-Tak Kang, Bong-Soon Chang, Choon-Ki Lee, Hyun Sik Seok, Jin S Yeom
BACKGROUND: There are no studies about the biomechanical analysis of lumbar decompression surgery in relation to degenerative changes of the lumbar spine. Therefore, the purpose of this study was to compare, by using finite element (FE) analysis, the biomechanical changes of the lumbar spine in terms of annulus stress and nucleus pressure after two different kinds of lumbar decompression surgery in relation to disc degenerative changes. METHODS: The validated intact and degenerated FE models (L2-5) were used in this study...
September 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28905044/is-there-a-relationship-between-blood-lipids-and-lumbar-disc-herniation-in-young-turkish-adults
#12
Nese Keser, Erhan Celikoglu, Merih İs, Zeynep Demet İlgezdi, Bendigar Sunar, Yusuf Sinan Aydin, Ahmet Ugur Kevenk, Bora Gurer, Ali Fatih Ramazanoglu, Nurgul Keser
INTRODUCTION: Atherosclerosis might diminish the nutrient supply to intervertebral discs (IVD), leading to disc herniation. Therefore, there is interest in determining the possible association between the blood lipid profile and lumbar disc herniation (LDH). We aimed to evaluate the association between blood lipids and LDH in a homogeneous group of patients, controlling for age- and sex-specific effects. MATERIAL AND METHODS: This is a case-control study which consisted of 100 individuals (mean age: 41...
2017: Arch Med Sci Atheroscler Dis
https://www.readbyqxmd.com/read/28901458/neuroprotective-effects-of-curcumin-alleviate-lumbar-intervertebral-disc-degeneration-through-regulating-the-expression-of-inos-cox%C3%A2-2-tgf%C3%A2-%C3%AE-1-2-mmp%C3%A2-9-and-bdnf-in-a-rat-model
#13
Yuan Hu, Jin-Shu Tang, Shu-Xun Hou, Xiu-Xiu Shi, Jiang Qin, Tie-Song Zhang, Xiao-Jing Wang
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. However, to the best of our knowledge, curcumin has yet to be investigated for the treatment of lumbar intervertebral disc degeneration LIDD). The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)‑2, transforming growth factor (TGF)‑β1/2, matrix metalloproteinase (MMP)‑9 and brain‑derived neurotrophic factor (BDNF) in a rat model of LIDD...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900744/structural-vertebral-endplate-nomenclature-and-etiology-a-study-by-the-issls-spinal-phenotype-focus-group
#14
Uruj Zehra, Cora Bow, Jeffrey C Lotz, Frances M K Williams, S Rajasekaran, Jaro Karppinen, Keith D K Luk, Michele C Battiê, Dino Samartzis
PURPOSE: Vertebral endplate abnormalities may be associated with disc degeneration and, perhaps, pain generation. However, consensus definitions for endplate findings on spine MRI do not exist, posing a challenge to compare findings between studies and ethnic groups. The following survey was created to characterize the variability among the global spine community regarding endplate structural findings with respect to nomenclature and etiology. METHODS: A working group within the International Society for the Study of the Lumbar Spine (ISSLS) Spinal Phenotype Focus Group was established to assess the endplate phenotype...
September 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28894387/modic-changes-of-the-cervical-spine-t1-slope-and-its-impact-on-axial-neck-pain
#15
Jia Li, Shuhui Qin, Yongqian Li, Yong Shen
BACKGROUND: The purpose of the research was to evaluate cervical sagittal parameters on magnetic resonance imaging (MRI) in patients with Modic changes and its impact on axial neck pain. METHODS: This study consisted of 266 consecutive asymptomatic or symptomatic patients with Modic changes, whose average age was 50.9±12.6 years from January 2015 to December 2016. Cervical sagittal parameters included sagittal alignment of the cervical spine (SACS), T1 slope, thoracic inlet angle (TIA), and neck tilt (NT)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28894375/impact-of-t1-slope-on-surgical-and-adjacent-segment-degeneration-after-bryan-cervical-disc-arthroplasty
#16
Peng Yang, Yongqian Li, Jia Li, Yong Shen
BACKGROUND: This retrospective study investigated an association between preoperative T1 slope and surgical and adjacent segment degeneration (SASD) after Bryan cervical disc arthroplasty (BCDA) in patients with cervical degenerative disc disease. METHODS: Based on preoperative standing lateral radiographs, 90 patients were classified according to T1 slope that was higher or lower than the 50th percentile (high T1 or low T1, 28 and 62 patients, respectively). Patients were also classified as SASD or non-SASD (38 and 52 patients, respectively) determined by radiographs at final follow-up...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28891440/a-systematic-review-of-mesenchymal-stem-cells-in-spinal-cord-injury-intervertebral-disc-repair-and-spinal-fusion
#17
Shujhat Khan, Pouya Mafi, Reza Mafi, Wasim Khan
Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, spine fusion and disc degeneration were included in this systematic review. Published articles up to January 2016 from MEDLINE, PubMed and Ovid were used by searching for specific terms. Of the 2595 articles found, 53 met the selection criteria and were included for analysis (16 on spinal cord injury, 28 on intervertebral disc repair and 9 on spinal fusion)...
September 7, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28887038/resveratrol-protects-against-mitochondrial-dysfunction-through-autophagy-activation-in-human-nucleus-pulposus-cells
#18
Baolong Zhang, Linfei Xu, Naiqiang Zhuo, Jieliang Shen
Intervertebral disc degeneration (IVDD) is closely related with aging, whereas mitochondrial damage is a common feature of aging that results in cell apoptosis. Resveratrol (RES) is a natural antioxidant that protects against mitochondrial dysfunction in various cells. This study aimed to investigate the protective role of RES against mitochondrial dysfunction and human nucleus pulposus cell (NPC) apoptosis. We found that mitochondrial dysfunction and NPC apoptosis could be induced under oxidative stress by 100 μmol/l of H2O2...
September 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28886203/a-novel-method-for-repeatable-failure-testing-of-annulus-fibrosus
#19
Benjamin Werbner, Minhao Zhou, Grace O'Connell
Tears in the annulus fibrosus (AF) of the intervertebral disc can result in herniation of the nucleus pulposus and progressive disc degeneration. Understanding AF failure mechanics is particularly important as research moves towards developing biological repair strategies for herniated discs. Unfortunately, failure mechanics of fiber-reinforced tissues, particularly those with fibers oriented off-axis from the applied load, is not well understood. Therefore, the objective of this study was to investigate the effectiveness of mid-length notch geometries in producing repeatable and consistent tissue failure within the gauge region of AF mechanical test specimens...
September 8, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28884563/expressions-and-significance-of-hif-1%C3%AE-and-aqp-3-in-intervertebral-disc-degeneration-tissues-of-cervical-spondylotic-myelopathy
#20
Xiangqi Tan, Yuqing Chen, Zhuyong Ji
No abstract text is available yet for this article.
September 7, 2017: Minerva Medica
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