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https://www.readbyqxmd.com/read/27928471/radiological-imaging-findings-of-scheuermann-disease
#1
Erkan Gokce, Murat Beyhan
AIM: To find accompanying anomalies of typical and atypical Scheuermann's disease (SD) is reported in the present study. METHODS: Study included 20 patients (16 men and 4 women) who had radiological imaging radiography, magnetic resonance imaging (MRI) and computed tomography, if available, due to back pain, curved back and low back pain in November 2011-February 2016 period. Patients were categorized into typical and atypical patterns based on the region involved...
November 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27928420/histopathological-changes-of-inner-retina-optic-disc-and-optic-nerve-in-rabbit-with-advanced-retinitis-pigmentosa
#2
Ken Asakawa, Hitoshi Ishikawa, Shigekazu Uga, Kimiyo Mashimo, Mineo Kondo, Hiroko Terasaki
We observed the histopathological changes of retinal ganglion cells (RGCs), optic disc, and optic nerve in rabbit with advanced retinitis pigmentosa (RP). Wild-type (WT) and rhodopsin transgenic (Tg) of RP rabbits were used at age 24 months. Light and electron microscopy were used to observe the retina, optic disc, and optic nerve. RGCs were also confirmed by immunofluorescent staining with a TUJ-1 monoclonal antibody. In addition to the rod and cone degeneration, we observed the astrocyte infiltration of the optic disc due to the damage of small RGCs and nerve fibres and atrophy of small optic nerve fibres...
December 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27927509/does-it-make-a-difference-to-stop-fusion-at-l3-versus-l4-in-terms-of%C3%A2-disc-and-facet-joint-degeneration-an-mri-study-with-minimum-5%C3%A2-years-follow-up
#3
Meric Enercan, Sinan Kahraman, Sinan Yilar, Mutlu Cobanoglu, Bahadir Huseyin Gokcen, Selhan Karadereler, Ayhan Mutlu, Levent Onur Ulusoy, Cagatay Ozturk, Erden Erturer, Elif Gebes, Tunay Sanli, Ahmet Alanay, Azmi Hamzaoglu
OBJECTIVES: To compare the functional outcomes of patients with idiopathic scoliosis who had surgical correction and fusion with all pedicle screw construct down to L3 or L4 and to evaluate whether saving a mobile lumbar motion segment distally would demonstrate any difference in terms of disc degeneration (DD) and facet joint degeneration (FJD) after minimum 5 years follow-up. SUMMARY OF BACKGROUND DATA: Selection of lowest instrumented vertebra (LIV) is often difficult when lumbar curve was included into the fusion (L3 vs L4)...
May 2016: Spine Deformity
https://www.readbyqxmd.com/read/27918900/differential-gene-expression-in-the-condylar-cartilage-of-growing-rabbits-with-temporomandibular-joint-anterior-disk-displacement-a-transcriptomic-study
#4
Shuhua Wang, Liquan Deng, Ye Li, Huiling Wu, Zhiyuan Gu
Internal derangement (ID) in the temporomandibular joint (TMJ) comprises a group of clinical problems with relatively high prevalence. However, the temporal changes in gene expression of condylar cartilage during continuous ID remain unclear. The aim of the current study is to investigate by microarray analysis, the differentially-expressed gene pattern in condylar cartilage of rabbits with ID from one to eight weeks of ID progression. Histological results (hematoxylin and eosin staining) indicated that abnormal collagen fiber arrangements, fragmentation of fibrils, and inflammatory cell-infiltration were detected from one to four weeks in joint disc specimens, while newly formed vessels, mucoid degeneration, meniscal tears, and the presence of osteoclasts and osteoblasts were observed at later time points...
November 6, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27917384/genetic-alterations-in-intervertebral-disc-disease
#5
REVIEW
Nikolay L Martirosyan, Arpan A Patel, Alessandro Carotenuto, M Yashar S Kalani, Evgenii Belykh, Corey T Walker, Mark C Preul, Nicholas Theodore
BACKGROUND: Intervertebral disc degeneration (IVDD) is considered a multifactorial disease that is influenced by both environmental and genetic factors. The last two decades of research strongly demonstrate that genetic factors contribute about 75% of the IVDD etiology. Recent total genome sequencing studies have shed light on the various single-nucleotide polymorphisms (SNPs) that are associated with IVDD. AIM: This review presents comprehensive and updated information about the diversity of genetic factors in the inflammatory, degradative, homeostatic, and structural systems involved in the IVDD...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27917347/identification-of-lumbar-disc-disease-hallmarks-a-large-cross-sectional-study
#6
Jun Zhang, Fei Zhao, Feng-Liang Wang, Yong-Feng Yang, Chen Zhang, Yue Cao, You-Lin Wang, Xiao-Juan Shi, Yi Wan, Min Zhang, Meng-Qiao Liu, Chun-Guang Zuo, Hai-Qiang Wang
BACKGROUND: Lumbar disc disease has a disabling impact on global people with heavy burden on society, mainly consisting of lumbar disc degeneration (LDD) and lumbar disc herniation (LDH). The recently released lumbar disc nomenclature version 2.0 deepens our understandings on the diseases. Consequently, there is an urgent need to clarify the occurrence and distribution features of LDD and LDH in a large-scale sample in terms of the novel version. QUESTION/PURPOSES: We asked: (1) Is there a difference in the occurrence and distribution hallmarks of LDD and LDH in a population-based large-scale sample? (2) Does the novel nomenclature version bring novel vision on lumbar disc disease? METHODS: Five thousand two hundred eighty-eight consecutive cases (26,440 lumbar discs) undergoing lumbar spine MRI were retrospectively included from Jan 2008 to Dec 2010 in a territory university hospital...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27916038/-mid-to-long-term-outcomes-of-cervical-disc-arthroplasty-for-symptomatic-cervical-disc-disease-a-meta-analysis
#7
S L Kan, B Yang, G Z Ning, S J Gao, J C Sun, S Q Feng
Objective: To compare the benefits and harms of cervical disc arthroplasty (CDA) with anterior cervical discectomy and fusion(ACDF) for symptomatic cervical disc disease at mid- to long-term follow-up. Methods: Electronic searches were made in PubMed, EMBASE, and the Cochrane Library for randomized controlled trials with at least 48 moths follow-up.Outcomes were reported as relative risk or standardized mean difference.Meta-analysis was carried out using Revman version 5.3 and Stata version 12.0. Results: Seven trials were included, involving 2 302 participants...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27916034/-the-mid-to-long-term-effect-of-wallis-lumbar-interspinous-dynamic-stabilization-on-the-adjacent-segment-degeneration
#8
X Yuan, C Kong, X M Chen, L B Cui, S J Xu, Y D Liu
Objective: To explore the mid- to long-term effect of Wallis interspinous dynamic stabilization system on the adjacent segment degeneration. Methods: From March 2009 to June 2010, in Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, 24 patients with L4-5 monosegmental lumbar disc herniation were treated with posterior lumbar decompression combined with Wallis interspinous dynamic fixation. Clinical outcomes were evaluated with visual analogue score (VAS) (back pain), VAS (leg pain) and oswestry disability index (ODI) score...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27909655/adjacent-disc-height-reduction-and-clinical-outcome-after-intradiscal-cement-leakage
#9
Minjie Shen, Junjie Niu, Haifei Zhou, Qian Meng, Minfeng Gan, Huilin Yang
OBJECTIVE: The purpose of this study is to evaluate the effect of intradiscal cement leakage on the height of adjacent cement-containing discs and the resulting clinical efficacy after kyphoplasty. METHODS: A total of 124 patients were included and classified into two groups: group A included 20 patients with intradiscal leakage, and group B contained 104 patients without intradiscal leakage. The mean follow-up time was 20.56±3.51 months. The height of the corresponding discs in both groups was measured using Farfan's method...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27906950/clinical-evaluation-and-magnetic-resonance-imaging-assessment-of-intradiscal-methylene-blue-injection-for-the-treatment-of-discogenic-low-back-pain
#10
XiaoJun Zhang, Jie Hao, Zhenming Hu, HaiTao Yang
BACKGROUND: Low back pain is a common worldwide health problem and has a significant socioeconomic impact on public health. Internal disc disruption has been considered as the most common cause of low back pain. Various therapies, including interbody fusion, disc replacement, injection therapies, and thermal annular procedures have been utilized for the treatment of discogenic low back pain. Recently, a new method of intradiscal methylene blue injection has been introduced to treat discogenic low back pain, but the clinical outcomes are controversial...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27893652/correlation-between-t2-t2-star-relaxation-time-and-cervical-intervertebral-disc-degeneration-an-observational-study
#11
Minghua Huang, Yong Guo, Qiong Ye, Lei Chen, Kai Zhou, Qingjun Wang, Lixin Shao, Qinglei Shi, Chun Chen
PURPOSE: To demonstrate the potential benefits of T2 relaxation time of intervertebral discs (IVDs) regarding the detection and grading of degenerative disc disease using 3.0-T magnetic resonance imaging (MRI) in a clinical setting. MATERIALS AND METHODS: Cervical sagittal T2-weighted, T2 relaxation MRI was performed at 3.0-T in 61 subjects, covering discs C2-3 to C6-7. All discs were morphologically assessed based on the Pfirrmann grade, and regions of interests (ROIs) were drawn over the T2 mapping...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27888084/are-locked-facets-a-contraindication-for-extreme-lateral-interbody-fusion
#12
Rodrigo Navarro-Ramirez, Gernot Lang, Yu Moriguchi, Eric Elowitz, Jose Alfredo Corredor, Mauricio J Avila, Alberto Gotfryd, Marjan Alimi, Lena Gandevia, Roger Härtl
BACKGROUND: Extreme lateral interbody fusion (ELIF) has gained popularity as a minimally invasive treatment allowing for indirect decompression of neural elements. However, evidence regarding the influence of facet degeneration (FD) and facet tropism (FT) towards indirect decompression is lacking. The aim of the study was to evaluate whether indirect decompression is impaired by FD and FT in patients undergoing ELIF. METHODS: 37 patients undergoing ELIF were included in a retrospective study...
November 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27885573/poly-%C3%AE-glutamic-acid-and-poly-%C3%AE-glutamic-acid-based-nanocomplexes-enhance-type-ii-collagen-production-in-intervertebral-disc
#13
Joana C Antunes, Catarina Leite Pereira, Graciosa Q Teixeira, Ricardo V Silva, Joana Caldeira, Sibylle Grad, Raquel M Gonçalves, Mário A Barbosa
Intervertebral disc (IVD) degeneration often leads to low back pain, which is one of the major causes of disability worldwide, affecting more than 80% of the population. Although available treatments for degenerated IVD decrease symptoms' progression, they fail to address the underlying causes and to restore native IVD properties. Poly(γ-glutamic acid) (γ-PGA) has recently been shown to support the production of chondrogenic matrix by mesenchymal stem/stromal cells. γ-PGA/chitosan (Ch) nanocomplexes (NCs) have been proposed for several biomedical applications, showing advantages compared with either polymer alone...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27885474/comparison-of-mri-defined-back-muscles-volume-between-patients-with-ankylosing-spondylitis-and-control-patients-with-chronic-back-pain-age-and-spinopelvic-alignment-matched-study
#14
Doo Hee Bok, Jihye Kim, Tae-Hwan Kim
PURPOSE: To compare MRI-defined back muscle volume between AS patients and age, and spinopelvic alignment matched control patients with chronic back pain. METHODS: 51 male patients with AS were enrolled. Age and spinopelvic alignment matched controls (male) were found among non-AS patients with chronic back pain. After matching procedure, fully matched controls were found in 31 of 51 AS patients (60.8%), who represent AS patients without deformity. However, matched controls were not found in 20 of 51 AS patients (39...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27879577/potential-involvement-of-the-il-6-jak-stat3-pathway-in-the-pathogenesis-of-intervertebral-disc-degeneration
#15
Satoshi Suzuki, Nobuyuki Fujita, Takeshi Fujii, Kota Watanabe, Mitsuru Yagi, Takashi Tsuji, Ken Ishii, Takeshi Miyamoto, Keisuke Horiuchi, Masaya Nakamura, Morio Matsumoto
STUDY DESIGN: Laboratory study. OBJECTIVE: To elucidate the potential involvement of the Interleukin-6 (IL-6) / Janus kinase (JAK) / Signal Transducers and Activator of Transcription (STAT3) pathway in the development of intervertebral disc (IVD) degeneration. SUMMARY OF BACKGROUND DATA: IL-6 plays a crucial role in IVD degeneration; however, the downstream intracellular signaling of IL-6 in the IVD is not fully understood. METHODS: The expression levels of IL-6 and Suppressors of Cytokine Signaling 3 (SOCS3), a target gene of the IL-6/JAK/STAT3 pathway, were evaluated in rat and human degenerated IVD samples...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27876503/cranio-caudal-asymmetries-in-trabecular-architecture-reflect-vertebral-fracture-patterns
#16
Ge Yang, Michele C Battié, Steven K Boyd, Tapio Videman, Yue Wang
Clinically, vertebral fractures often occur in the upper lumbar spine and involve the superior endplate of a vertebra (which is immediately caudal to a disc). Knowledge that the cranial endplate of a disc is thicker and has greater bone mineral density (BMD) than the corresponding caudal endplate helps to explain this phenomenon. In this study, we investigated structural differences in vertebral trabeculae on either side of a lumbar disc to provide further insight into vertebral fracture risk. As the focus is trabecular difference within a spinal motion segment, we define cranial and caudal vertebral trabeculae relative to the disc...
November 19, 2016: Bone
https://www.readbyqxmd.com/read/27876065/expression-of-adiponectin-receptors-in-human-and-rat-intervertebral-disc-cells-and-changes-in-receptor-expression-during-disc-degeneration-using-a-rat-tail-temporary-static-compression-model
#17
Yoshiki Terashima, Kenichiro Kakutani, Takashi Yurube, Toru Takada, Koichiro Maeno, Hiroaki Hirata, Shingo Miyazaki, Masaaki Ito, Yuji Kakiuchi, Yoshiki Takeoka, Ryosuke Kuroda, Kotaro Nishida
BACKGROUND: Adipose tissue is a large endocrine organ known to secret adiponectin, which has anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Adiponectin is widely involved in systemic disease, diabetes mellitus, and cardiac infraction. This study aimed to investigate the involvement of adiponectin in intervertebral disc (IVD) degeneration. METHODS: Adipose and IVD tissues were obtained from human patients undergoing surgery (n = 4) and from skeletally mature Sprague-Dawley rats (n = 21)...
November 22, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27872846/effect-of-static-load-on-the-nucleus-pulposus-of-rabbit-intervertebral-disc-motion-segment-in-an-organ-culture
#18
Jia-Wen Zhan, Min-Shan Feng, Li-Guo Zhu, Ping Zhang, Jie Yu
The development of mechanically active culture systems helps in understanding of the role of mechanical stress in intervertebral disc (IVD) degeneration. Motion segment cultures facilitate the application and control of mechanical loads. The purpose of this study was to establish a culturing method for rabbit IVD motion segments to observe the effect of static load on the whole disc organ. Segments were cultured in custom-made apparatuses under a constant, compressive load (3 kg) for 2 weeks. Tissue integrity, matrix synthesis, and matrix gene expression profile were assessed and compared with fresh one...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27871028/microstructure-analysis-method-for-evaluating-degenerated-intervertebral-disc-tissue
#19
Andrea Friedmann, Felix Goehre, Christopher Ludtka, Thomas Mendel, Hans-Joerg Meisel, Andreas Heilmann, Stefan Schwan
Degeneration of intervertebral disc (IVD) tissue is characterized by several structural changes that result in variations in disc physiology and loss of biomechanical function. The complex process of degeneration exhibits highly intercorrelated biomechanical, biochemical, and cellular interactions. There is currently some understanding of the cellular changes in degenerated intervertebral disc tissue, but microstructural changes and deterioration of the tissue matrix has previously been rarely explored. In this work, sequestered IVD tissue was successfully characterized using histology, light microscopy, and scanning electron microscopy (SEM) to quantitatively evaluate parameters of interest for intervertebral disc degeneration (IDD) such as delamination of the collagenous matrix, cell density, cell size, and extra cellular matrix (ECM) thickness...
October 21, 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27870867/preserving-posterior-complex-can-prevent-adjacent-segment-disease-following-posterior-lumbar-interbody-fusion-surgeries-a-finite-element-analysis
#20
Yun-Peng Huang, Cheng-Fei Du, Cheng-Kung Cheng, Zheng-Cheng Zhong, Xuan-Wei Chen, Gui Wu, Zhe-Cheng Li, Jin-Duo Ye, Jian-Hua Lin, Li Zhen Wang
OBJECTIVE: To investigate the biomechanical effects of the lumbar posterior complex on the adjacent segments after posterior lumbar interbody fusion (PLIF) surgeries. METHODS: A finite element model of the L1-S1 segment was modified to simulate PLIF with total laminectomy (PLIF-LAM) and PLIF with hemilaminectomy (PLIF-HEMI) procedures. The models were subjected to a 400N follower load with a 7.5-N.m moment of flexion, extension, torsion, and lateral bending. The range of motion (ROM), intradiscal pressure (IDP), and ligament force were compared...
2016: PloS One
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