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https://www.readbyqxmd.com/read/28526405/hypoxia-inducible-factor-l%C3%AE-mediates-aggrecan-and-collagen-%C3%AE-expression-via-notch1-signaling-in-nucleus-pulposus-cells-during-intervertebral-disc-degeneration
#1
Zhuochao Liu, Changwei Li, Xiangchao Meng, Yunting Bai, Jin Qi, Jun Wang, Qi Zhou, Weibin Zhang, Xingkai Zhang
Although hypoxia-inducible factor-lα (HIF-lα) has been reported to have an important role in the metabolism and synthesis of the extracellular matrix (ECM) of nucleus pulposus cells (NPCs), the underlying mechanism has not been fully clarified. Here, we show for the first time that NOTCH1 expression is decreased in NPs isolated from degenerated human intervertebral discs (IVDs), as well as in the NPs of NP-specific HIF-1α(-/-) mice. Our study reveals that overexpression of HIF-1α leads to increased expression of NOTCH1, the NOTCH1 ligand JAGGED1, and its target gene hairy and enhancer of split-1 (HES1), while also upregulating collagen Π and aggrecan expression in human NPCs...
May 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28525292/comparison-of-adjacent-segment-degeneration-after-nonrigid-fixation-system-and-posterior-lumbar-interbody-fusion-for-single-level-lumbar-disc-herniation-a-new-method-of-mri-analysis-of-lumbar-nucleus-pulposus-volume
#2
Shaofeng Yang, Yanan Liu, Zhaohua Bao, Jun Zou, Huilin Yang
PURPOSE: To evaluate the influence of a nonrigid fixation system and posterior lumbar interbody fusion on adjacent intervertebral disc degeneration by using MRI analysis of lumbar nucleus pulposus volume for single-level lumbar disc herniation. MATERIALS AND METHODS: We selected 112 patients who underwent nonrigid fixation (17 men and 44 women) or posterior lumbar interbody fusion (13 men and 38 women) for this retrospective study. Based on the T2-weighted magnetic resonance imaging (MRI) scans taken preoperatively, and 6, 12, and 24 months after surgery, the nucleus pulposus in the upper segments of the operated level was considered an ellipsoid, and their volumes were measured respectively and then compared between the two groups...
May 19, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28514734/inflammatory-microrna-194-and-515-attenuate-the-biosynthesis-of-chondroitin-sulfate-during-human-intervertebral-disc-degeneration
#3
Bo Hu, Chen Xu, Ye Tian, Changgui Shi, Ying Zhang, Lianfu Deng, Hongyu Zhou, Peng Cao, Huajiang Chen, Wen Yuan
Intervertebral disc degeneration (IDD) is characterized by dehydration and loss of extracellular matrixes in the nucleus pulposus region. Chondroitin sulfate has been found to be the water-binding molecule that played a key role in IDD. Although investigators have reported that inflammatory cytokines are involved in the reduction of chondroitin sulfate in IDD, but the underlying mechanism is unrevealed. Since chondroitin sulfate synthesis is controlled by chondroitin sulfate glycosyltransferases CHSY-1/2/3 and CSGALNACT-1/2, their functional role and regulatory mechanism in IDD is not fully studied...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512264/gallic-acid-inhibits-the-release-of-adamts4-in-nucleus-pulposus-cells-by-inhibiting-p65-phosphorylation-and-acetylation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#4
Yao Huang, Jian Chen, Tao Jiang, Zheng Zhou, Bin Lv, Guoyong Yin, Jin Fan
This study investigated the inhibitory effect of gallic acid (GA) on the release of A Disintegrin and Metalloproteinase with Thrombospondin motifs 4 (ADAMTS4) through the regulation of the NF-κB signaling pathway, which is closely related to the matrix metalloproteinases in nucleus pulposus cells. Different concentrations of GA were added to TNF-α-induced human nucleus pulposus cells (hNPCs) and intervertebral disc degeneration rat model. ADAMTS-4 expression increased both in the TNF-α-induced nucleus pulposus cells and intervertebral disc degeneration rat model...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28511972/a-matched-cohort-comparison-of-cervical-disc-arthroplasty-versus-anterior-cervical-discectomy-and-fusion-evaluating-perioperative-outcomes
#5
Pavan S Upadhyayula, John K Yue, Erik I Curtis, Reid Hoshide, Joseph D Ciacci
OBJECTIVE: Cervical disc arthroplasty (CDA) is a recent alternative to anterior cervical discectomy and fusion (ACDF) in patients suffering cervical disc herniation and degeneration. To date, a systematic analysis of their comparative advantages and risks following elective surgery remains elusive. METHODS: Adult patients undergoing elective CDA or ACDF were extracted from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database years 2011-2014...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28509587/link-protein-n-terminal-peptide-and-fullerol-promote-matrix-production-and-decrease-degradation-enzymes-in-rabbit-annulus-cells
#6
Ching-Hua Yeh, Dennis Chen, Bayan Aghdasi, Li Xiao, Mengmeng Ding, Li Jin, Xudong Li
PURPOSE: Intervertebral disc degeneration is a major cause of back pain. Novel therapies for prevention or reversal of disc degeneration are needed. It is desirable for potential therapies to target both inflammation and matrix degeneration. MATERIALS AND METHODS: The combined regenerative potential of link protein N-terminal peptide (LN) and fullerol on annulus fibrosus (AF) cells was evaluated in a 3D culture model. RESULTS: IL-1α-induced AF cell degeneration was counteracted by fullerol, LN, and fullerol + LN, with the latter having the greatest effect on matrix production as evaluated by real-time PCR and GAG assay...
May 16, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28507882/aquaporin-1-expression-in-herniated-human-lumbar-intervertebral-discs
#7
Haydn Hoffman, Aaron W Choi, Victor Chang, Jon Kimball, Alan S Verkman, Rubeen Virani, Brian Kim, Tianyi Niu, Daniel C Lu
STUDY DESIGN: Case series. OBJECTIVE: Intervertebral disc (IVD) degeneration is the cause of spondylosis. The pathogenesis is poorly understood, but disc dehydration often plays a role. In this study, we aim to identify and quantify aquaporin-1 (AQP1) in ex vivo human degenerated IVDs obtained intraoperatively and to investigate the relationship between AQP1 levels and magnetic resonance imaging (MRI) T2 intensity of the disc. METHODS: Ex vivo samples of nucleus pulposus (NP) tissue from lumbar IVDs were obtained from 18 consecutive patients who underwent surgery for disc herniation at L4/5 and L5/S1 level...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28506227/associations-between-disc-space-narrowing-anterior-osteophytes-and-disability-in-chronic-mechanical-low-back-pain-a-cross-sectional-study
#8
Romain Shanil Perera, Poruwalage Harsha Dissanayake, Upul Senarath, Lalith Sirimevan Wijayaratne, Aranjan Lional Karunanayake, Vajira Harshadeva Weerabaddana Dissanayake
BACKGROUND: Radiographic features of lumbar disc degeneration (LDD) are common findings in patients with chronic mechanical low back pain; however, its role in disability and intensity of pain is debatable. This study aims to investigate the associations of the x-ray features of LDD and lumbar spondylolisthesis with severity of disability and intensity of pain. METHODS: A cross-sectional study was conducted on 439 patients with chronic mechanical low back pain who attended the rheumatology clinic, National Hospital of Sri Lanka, Colombo, from May 2012 to May 2014...
May 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28505960/normal-aging-of-the-lumbar-spine-in-women
#9
Hulya Kurtul Yildiz, Elif Evrim Ekin
BACKGROUND: Lumbar lordosis is required for bipedalism. OBJECTIVES: To investigate age-related changes in lumbar lordosis and to clarify the relationships between lumbar lordosis and vertebral wedging and disc degeneration. METHODS: A total of 300 women were included in this retrospective study, 50 in each of six age groups (20-, 30-, 40-, 50-, 60- and 70-year-olds). Patients with vertebral collapse, instable fracture or disc sequestration were excluded...
May 5, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28505597/an-interpenetrating-network-strengthened-and-toughened-hydrogel-that-supports-cell-based-nucleus-pulposus-regeneration
#10
Yibo Gan, Pei Li, Liyuan Wang, Xiumei Mo, Lei Song, Yuan Xu, Chen Zhao, Bin Ouyang, Bing Tu, Lei Luo, Linyong Zhu, Shiwu Dong, Fuyou Li, Qiang Zhou
Hydrogel is a suitable scaffold for the nucleus pulposus (NP) regeneration. However, its unmatched mechanical properties lead to implant failure in late-stage disc degeneration because of structural failure and implant extrusion after long-term compression. In this study, we evaluated an interpenetrating network (IPN)-strengthened and toughened hydrogel for NP regeneration, using dextran and gelatin as the primary network while poly (ethylene glycol) as the secondary network. The aim of this study was to realize the NP regeneration using the hydrogel...
May 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28501956/an-in-vitro-evaluation-of-sagittal-alignment-in-the-cervical-spine-after-insertion-of-supraphysiologic-lordotic-implants
#11
Donald J Blaskiewicz, Jeffrey E Harris, Patrick P Han, Alexander W Turner, Gregory M Mundis
PURPOSE: Cervical spine malalignment can develop as a consequence of degenerative disc disease or following spinal surgery. When normal sagittal alignment of the spine is disrupted, further degeneration may occur adjacent to the deformity. The purpose of this study was to investigate changes in lordosis and sagittal alignment in the cervical spine after insertion of supraphysiologic lordotic implants. METHODS: Eight cadaveric cervical spines (Occiput-T1) were tested...
May 13, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28501720/characterization-and-restoration-of-degenerated-ivd-function-with-an-injectable-in-situ-gelling-alginate-hydrogel-an-in-vitro-and-ex-vivo-study
#12
Emily A Growney Kalaf, Meghana Pendyala, J Gary Bledsoe, Scott A Sell
Intervertebral disc (IVD) degeneration is a naturally, irreparable process that causes loss in IVD hydration, cellularity, and, mechanical stability. Invasive surgical attempts to ease back pain and, radiculopathy have shown to cause increased degeneration along the rest, of the spine. Due to its highly tunable mechanical and degradation, properties, alginate is a viable option for a less-invasive injectable, repair for IVD degeneration. This study centers on the characterization, of in situ gelling alginate and subsequent injection into enzymatically, degraded motion segments...
May 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28500930/micro-computed-tomography-scanning-electron-microscopy-and-energy-x-ray-spectroscopy-studies-of-facet-joint-degeneration-a-comparison-to-clinical-imaging
#13
Felix Goehre, Christopher Ludtka, Melanie Hamperl, Andrea Friedmann, Anja Straube, Thomas Mendel, Andreas Heilmann, Hans Jörg Meisel, Stefan Schwan
Segmental degeneration in the human lumbar spine affects both the intervertebral discs and facet joints. Facet joint degeneration not only affects the cartilage surface, but also alters the cellular properties of the cartilage tissue and the structure of the subchondral bone. The primary focus of this study is the investigation of these microstructural changes that are caused by facet joint degeneration. Microstructural analyses of degenerated facet joint samples, obtained from patients following operative lumbar interbody fusion, have not previously been extensively investigated...
May 1, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28499451/effects-of-annulus-defects-and-implantation-of-poly-lactic-co-glycolic-acid-plga-fibrin-gel-scaffolds-on-nerves-ingrowth-in-a-rabbit-model-of-annular-injury-disc-degeneration
#14
Long Xin, Weixing Xu, Leijun Yu, Shunwu Fan, Wei Wang, Fang Yu, Zhenbin Wang
BACKGROUND: Growth of nerve fibers has been shown to occur in a rabbit model of intravertebral disc degeneration (IVD) induced by needle puncture. As nerve growth may underlie the process of chronic pain in humans affected by disc degeneration, we sought to investigate the factors underlying nerve ingrowth in a minimally invasive annulotomy rabbit model of IVD by comparing the effects of empty disc defects with those of defects filled with poly(lactic-co-glycolic acid)/fibrin gel (PLGA) plugs...
May 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28498809/follistatin-like-protein-1-promotes-inflammatory-reactions-in-nucleus-pulposus-cells-by-interacting-with-the-mapk-and-nf%C3%AE%C2%BAb-signaling-pathways
#15
Yi Liu, Jianlu Wei, Yunpeng Zhao, Yuanqiang Zhang, Yingguang Han, Bin Chen, Kaiyuan Cheng, Jialin Jia, Lin Nie, Lei Cheng
OBJECTIVE: Follistatin-like protein 1 (FSTL1) is a well-known mediator of inflammation. Intervertebral disc disease is an inflammatory disorder. Here, we investigated the role of FSTL1 in the intervertebral discs inflammation. METHODS: Expression of FSTL1 in nucleus pulposus tissues from rats and human was determined by immunohistochemistry staining and western blot analysis. The expression levels of tumor necrosis factor-α (TNF-α), interleukin1-β (IL-1β) and matrix metalloproteinase 13 (MMP-13) in human and rat nucleus pulposus tissues were measured by immunohistochemistry staining...
April 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498326/a-histopathological-scheme-for-the-quantitative-scoring-of-intervertebral-disc-degeneration-and-the-therapeutic-utility-of-adult-mesenchymal-stem-cells-for-intervertebral-disc-regeneration
#16
Cindy C Shu, Margaret M Smith, Susan M Smith, Andrew J Dart, Christopher B Little, James Melrose
The purpose of this study was to develop a quantitative histopathological scoring scheme to evaluate disc degeneration and regeneration using an ovine annular lesion model of experimental disc degeneration. Toluidine blue and Haematoxylin and Eosin (H&E) staining were used to evaluate cellular morphology: (i) disc structure/lesion morphology; (ii) proteoglycan depletion; (iii) cellular morphology; (iv) blood vessel in-growth; (v) cell influx into lesion; and (vi) cystic degeneration/chondroid metaplasia...
May 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28498027/asthma-and-early-herniated-intervertebral-disc-disease
#17
Cheng-Di Chiu, Hsuan-Ju Chen, Hean-Pat Saw, Nai-Wei Yao, Hung-Rong Yen, Chia-Hung Kao
BACKGROUND: The etiology of herniated intervertebral disc (HIVD) disease in children and adolescents is multifactorial and not merely related to disc degeneration. Therefore, in the present study, we investigated the relationship between young asthma patients and the risk of early HIVD disease in a population under 30 years of age. MATERIALS AND METHODS: Data from the National Health Insurance Research Database (NHIRD) of Taiwan were used to conduct a retrospective longitudinal cohort study...
May 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28497435/genetic-dimension-of-intervertebral-disc-degeneration-polymorphism-of-matrix-metalloproteinase-1-and-3-in-the-north-iranian-population
#18
Alia Saberi, Zivar Salehi, Bahram Naderinabi, Sahar Hojaat Ansari, Sohail Mashayekhi
AIM: Exploring the relationship between two polymorphisms (MMP-1-755 T/G [rs498186] and MMP-3 A/C [rs632478]) and disc degeneration. MATERIAL AND METHODS: We performed a case-control study on 130 cases with intervertebral disc degeneration confirmed by Magnetic Resonance Imaging (MRI) and 210 healthy individuals. Schneiderman criterion was used to determine the severity of the disc degeneration. Blood samples were collected from the participants. The genotyping was performed by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method...
April 4, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28495754/phd3-is-a-transcriptional-coactivator-of-hif-1%C3%AE-in-nucleus-pulposus-cells-independent-of-the-pkm2-jmjd5-axis
#19
Zachary R Schoepflin, Elizabeth S Silagi, Irving M Shapiro, Makarand V Risbud
The role of prolyl hydroxylase (PHD)-3 as a hypoxia inducible factor (HIF)-1α cofactor is controversial and remains unknown in skeletal tissues. We investigated whether PHD3 controls HIF-1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase muscle (PKM)-2-Jumonji domain--containing protein (JMJD5) axis. PHD3(-/-) mice (12.5 mo old) showed increased incidence of intervertebral disc degeneration with a concomitant decrease in expression of the HIF-1α targets VEGF-A, glucose transporter-1, and lactate dehydrogenase A...
May 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28488093/trends-analysis-of-surgical-procedures-for-cervical-degenerative-disc-disease-and-myelopathy-in-patients-with-tobacco-use-disorder
#20
Phillip Grisdela, Zorica Buser, Anthony D'Oro, Permsak Paholpak, John C Liu, Jeffrey C Wang
PURPOSE: This study defined the incidence and trends of surgeries performed for patients with cervical disc degeneration with and without tobacco use disorder (TUD). METHODS: This study utilized the Humana Inc. database between 2007 and 2013 to identify patients with cervical disc degeneration with or without myelopathy. International Classification of Diseases, ninth revision (ICD-9) and Current Procedural Terminology (CPT) codes determined the initial diagnosis of disc degeneration, myelopathy status and TUD, whether patients received surgery, and TUD status at surgery...
May 9, 2017: European Spine Journal
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