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https://www.readbyqxmd.com/read/28487537/evidence-of-cross-cutting-and-redox-reaction-in-khatyrka-meteorite-reveals-metallic-al-minerals-formed-in-outer-space
#1
Chaney Lin, Lincoln S Hollister, Glenn J MacPherson, Luca Bindi, Chi Ma, Christopher L Andronicos, Paul J Steinhardt
We report on a fragment of the quasicrystal-bearing CV3 carbonaceous chondrite Khatyrka recovered from fine-grained, clay-rich sediments in the Koryak Mountains, Chukotka (Russia). We show higher melting-point silicate glass cross-cutting lower melting-point Al-Cu-Fe alloys, as well as unambiguous evidence of a reduction-oxidation reaction history between Al-Cu-Fe alloys and silicate melt. The redox reactions involve reduction of FeO and SiO2 to Fe and Fe-Si metal, and oxidation of metallic Al to Al2O3, occurring where silicate melt was in contact with Al-Cu-Fe alloys...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28457228/differences-in-gut-microbial-composition-correlate-with-regional-brain-volumes-in-irritable-bowel-syndrome
#2
Jennifer S Labus, Emily B Hollister, Jonathan Jacobs, Kyleigh Kirbach, Numan Oezguen, Arpana Gupta, Jonathan Acosta, Ruth Ann Luna, Kjersti Aagaard, James Versalovic, Tor Savidge, Elaine Hsiao, Kirsten Tillisch, Emeran A Mayer
BACKGROUND: Preclinical and clinical evidence supports the concept of bidirectional brain-gut microbiome interactions. We aimed to determine if subgroups of irritable bowel syndrome (IBS) subjects can be identified based on differences in gut microbial composition, and if there are correlations between gut microbial measures and structural brain signatures in IBS. METHODS: Behavioral measures, stool samples, and structural brain images were collected from 29 adult IBS and 23 healthy control subjects (HCs)...
May 1, 2017: Microbiome
https://www.readbyqxmd.com/read/28424075/computational-modeling-of-airway-instability-and-collapse-in-tracheomalacia
#3
Scott J Hollister, Maximilian P Hollister, Sebastian K Hollister
BACKGROUND: Tracheomalacia (TM) is a condition of excessive tracheal collapse during exhalation. Both acquired and congenital forms of TM are believed to result from morphological changes in cartilaginous, fibrous and/or smooth muscle tissues reducing airway mechanical properties to a degree that precipitates collapse. However, neither the specific amount of mechanical property reduction nor the malacic segment lengths leading to life threatening airway collapse in TM are known. Furthermore, the specific mechanism of collapse is still debated...
April 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28380379/%C3%AE-cell-aging-markers-have-heterogeneous-distribution-and-are-induced-by-insulin-resistance
#4
Cristina Aguayo-Mazzucato, Mark van Haaren, Magdalena Mruk, Terence B Lee, Caitlin Crawford, Jennifer Hollister-Lock, Brooke A Sullivan, James W Johnson, Aref Ebrahimi, Jonathan M Dreyfuss, Jan Van Deursen, Gordon C Weir, Susan Bonner-Weir
We hypothesized that the known heterogeneity of pancreatic β cells was due to subpopulations of β cells at different stages of their life cycle with different functional capacities and that further changes occur with metabolic stress and aging. We identified new markers of aging in β cells, including IGF1R. In β cells IGF1R expression correlated with age, dysfunction, and expression of known age markers p16(ink4a), p53BP1, and senescence-associated β-galactosidase. The new markers showed striking heterogeneity both within and between islets in both mouse and human pancreas...
April 4, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28341746/leveraging-sequence-based-faecal-microbial-community-survey-data-to-identify-a-composite-biomarker-for-colorectal-cancer
#5
Manasi S Shah, Todd Z DeSantis, Thomas Weinmaier, Paul J McMurdie, Julia L Cope, Adam Altrichter, Jose-Miguel Yamal, Emily B Hollister
OBJECTIVE: Colorectal cancer (CRC) is the second leading cause of cancer-associated mortality in the USA. The faecal microbiome may provide non-invasive biomarkers of CRC and indicate transition in the adenoma-carcinoma sequence. Re-analysing raw sequence and metadata from several studies uniformly, we sought to identify a composite and generalisable microbial marker for CRC. DESIGN: Raw 16S rRNA gene sequence data sets from nine studies were processed with two pipelines, (1) QIIME closed reference (QIIME-CR) or (2) a strain-specific method herein termed SS-UP (Strain Select, UPARSE bioinformatics pipeline)...
March 24, 2017: Gut
https://www.readbyqxmd.com/read/28274256/intestinal-dysbiosis-in-preterm-infants-preceding-necrotizing-enterocolitis-a-systematic-review-and-meta-analysis
#6
REVIEW
Mohan Pammi, Julia Cope, Phillip I Tarr, Barbara B Warner, Ardythe L Morrow, Volker Mai, Katherine E Gregory, J Simon Kroll, Valerie McMurtry, Michael J Ferris, Lars Engstrand, Helene Engstrand Lilja, Emily B Hollister, James Versalovic, Josef Neu
BACKGROUND: Necrotizing enterocolitis (NEC) is a catastrophic disease of preterm infants, and microbial dysbiosis has been implicated in its pathogenesis. Studies evaluating the microbiome in NEC and preterm infants lack power and have reported inconsistent results. METHODS AND RESULTS: Our objectives were to perform a systematic review and meta-analyses of stool microbiome profiles in preterm infants to discern and describe microbial dysbiosis prior to the onset of NEC and to explore heterogeneity among studies...
March 9, 2017: Microbiome
https://www.readbyqxmd.com/read/28245199/additive-manufacturing-of-polymer-melts-for-implantable-medical-devices-and-scaffolds
#7
Almoatazbellah Youssef, Scott J Hollister, Paul D Dalton
Melt processing is routinely used to fabricate medical polymeric devices/implants for clinical reconstruction and can be incorporated into quality systems procedures for medical device manufacture. As additive manufacturing (AM) becomes increasingly used for biomaterials and biofabrication, the translation of new, customizable, medical devices to the clinic becomes paramount. Melt processing is therefore a distinguishable group within AM that provides an avenue to manufacture scaffolds/implants with a clinical end-point...
February 28, 2017: Biofabrication
https://www.readbyqxmd.com/read/28148964/cellular-prion-protein-is-present-in-mitochondria-of-healthy-mice
#8
Robert Faris, Roger A Moore, Anne Ward, Brent Race, David W Dorward, Jason R Hollister, Elizabeth R Fischer, Suzette A Priola
Cellular prion protein (PrP(C)) is a mammalian glycoprotein which is usually found anchored to the plasma membrane via a glycophosphatidylinositol (GPI) anchor. PrP(C) misfolds to a pathogenic isoform PrP(Sc), the causative agent of neurodegenerative prion diseases. The precise function of PrP(C) remains elusive but may depend upon its cellular localization. Here we show that PrP(C) is present in brain mitochondria from 6-12 week old wild-type and transgenic mice in the absence of disease. Mitochondrial PrP(C) was fully processed with mature N-linked glycans and did not require the GPI anchor for localization...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28125750/treatment-of-severe-acquired-tracheomalacia-with-a-patient-specific-3d-printed-permanent-tracheal-splint
#9
Robert J Morrison, Shayan Sengupta, Colleen L Flanangan, Richard G Ohye, Scott J Hollister, Glenn E Green
No abstract text is available yet for this article.
May 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28079308/greater-temperature-sensitivity-of-plant-phenology-at-colder-sites-implications-for-convergence-across-northern-latitudes
#10
Janet Prevéy, Mark Vellend, Nadja Rüger, Robert D Hollister, Anne D Bjorkman, Isla H Myers-Smith, Sarah C Elmendorf, Karin Clark, Elisabeth J Cooper, Bo Elberling, Anna Maria Fosaa, Gregory H R Henry, Toke T Høye, Ingibjörg Svala Jónsdóttir, Kari Klanderud, Esther Lévesque, Marguerite Mauritz, Ulf Molau, Susan M Natali, Steven F Oberbauer, Zoe A Panchen, Eric Post, Sabine B Rumpf, Niels M Schmidt, Ted Schuur, Phillip R Semenchuk, Tiffany Troxler, Jeffrey M Welker, Christian Rixen
Warmer temperatures are accelerating the phenology of organisms around the world. Temperature sensitivity of phenology might be greater in colder, higher-latitude sites than in warmer regions, in part because small changes in temperature constitute greater relative changes in thermal balance at colder sites. To test this hypothesis, we examined up to 20 years of phenology data for 47 tundra plant species at 18 high-latitude sites along a climatic gradient. Across all species, the timing of leaf emergence and flowering were more sensitive to a given increase in summer temperature at colder than warmer high-latitude locations...
January 11, 2017: Global Change Biology
https://www.readbyqxmd.com/read/27936278/the-relationship-between-grammatical-development-and-disfluencies-in-preschool-children-who-stutter-and-those-who-recover
#11
Julia Hollister, Amanda Owen Van Horne, Patricia Zebrowski
Purpose: The dual diathesis stressor model indicates that a mismatch between a child's endogenous linguistic abilities and exogenous linguistic contexts is one factor that contributes to stuttering behavior. In the present study, we used a developmental framework to investigate if reducing the gap between endogenous and exogenous linguistics factors would result in less disfluency for typical children, children who recover from stuttering (CWS-R), and children who persist. Method: Children between 28 and 43 months of age participated in this study: 8 typical children, 5 CWS-R, and 8 children who persist...
February 1, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27935209/tailoring-the-physicochemical-and-shape-memory-properties-of-the-biodegradable-polymer-poly-glycerol-dodecanoate-via-curing-conditions
#12
Loran D Solorio, Martin L Bocks, Scott J Hollister
A major challenge in the repair and regeneration of soft tissue damage occurring as a result of aging, injury, or disease is recapitulating the biomechanical properties of the native tissue. Ideally, a candidate biomaterial for soft tissue engineering applications should be biocompatible, nonlinearly elastic to match soft tissue mechanical behavior, biodegradable to enable tissue remodeling, and tailorable to achieve a range of nonlinear elastic mechanical properties to match specific soft tissues. In addition, for cardiac and other applications, the biomaterial should have shape memory characteristics to facilitate minimally invasive and/or catheter-based delivery...
June 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27896978/development-and-performance-of-text-mining-algorithms-to-extract-socioeconomic-status-from-de-identified-electronic-health-records
#13
Brittany M Hollister, Nicole A Restrepo, Eric Farber-Eger, Dana C Crawford, Melinda C Aldrich, Amy Non
Socioeconomic status (SES) is a fundamental contributor to health, and a key factor underlying racial disparities in disease. However, SES data are rarely included in genetic studies due in part to the difficultly of collecting these data when studies were not originally designed for that purpose. The emergence of large clinic-based biobanks linked to electronic health records (EHRs) provides research access to large patient populations with longitudinal phenotype data captured in structured fields as billing codes, procedure codes, and prescriptions...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27764088/ten-simple-rules-for-digital-data-storage
#14
EDITORIAL
Edmund M Hart, Pauline Barmby, David LeBauer, François Michonneau, Sarah Mount, Patrick Mulrooney, Timothée Poisot, Kara H Woo, Naupaka B Zimmerman, Jeffrey W Hollister
No abstract text is available yet for this article.
October 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27711917/advances-in-3-dimensional-printing-in-otolaryngology-a-review
#15
Kyle K VanKoevering, Scott J Hollister, Glenn E Green
Importance: Three-dimensional (3-D) printing is an exponentially growing technology that enables the use of a patient's image data to create patient-specific models, devices, and implants. Three-dimensional printing, developed in the 1980s, has emerged in the past decade with the potential to create new paradigms in personalized medicine. Observations: The field of otolaryngology has advanced many current and evolving future medical applications of 3-D printing...
February 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27593871/different-responses-in-induction-of-allergen-specific-immunoglobulin-g4-and-ige-blocking-factors-for-three-mite-subcutaneous-immunotherapy-products
#16
Kyung Hee Park, Sang Chul Lee, Young Woong Son, Kyoung Yong Jeong, Yoo Seob Shin, Jung U Shin, Da Woon Sim, Hye Jung Park, Jae Hyun Lee, Kwang Hoon Lee, Jung Won Park
PURPOSE: Specific immunoglobulin G4 (sIgG4) and immunoglobulin E (IgE)-blocking factors produced by subcutaneous immunotherapy (SCIT) play a critical role in the induction of allergen tolerance. However, comparative studies of available SCIT reagents on the induction of sIgG4 are limited. We compared increases in sIgG4 for three different house dust mite (HDM) SCIT reagents. MATERIALS AND METHODS: Seventy-two HDM sensitized allergic patients were enrolled and classified into four groups: 1) control (n=27), 2) SCIT with Hollister-Stier® (n=19), 3) Tyrosine S® (n=16), and 4) Novo-Helisen® (n=10)...
November 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27582889/the-mucosal-microbiota-in-a-young-child-with-severe-non-helicobacter-gastritis
#17
Geoffrey A Preidis, Ruth Ann Luna, Emily B Hollister, Deborah Schady, Chunxu Gao, Milton J Finegold, James Versalovic, Robert J Shulman
No abstract text is available yet for this article.
September 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27458085/gaba-producing-bifidobacterium-dentium-modulates-visceral-sensitivity-in-the-intestine
#18
K Pokusaeva, C Johnson, B Luk, G Uribe, Y Fu, N Oezguen, R K Matsunami, M Lugo, A Major, Y Mori-Akiyama, E B Hollister, S M Dann, X Z Shi, D A Engler, T Savidge, J Versalovic
BACKGROUND: Recurrent abdominal pain is a common and costly health-care problem attributed, in part, to visceral hypersensitivity. Increasing evidence suggests that gut bacteria contribute to abdominal pain perception by modulating the microbiome-gut-brain axis. However, specific microbial signals remain poorly defined. γ-aminobutyric acid (GABA) is a principal inhibitory neurotransmitter and a key regulator of abdominal and central pain perception from peripheral afferent neurons. Although gut bacteria are reported to produce GABA, it is not known whether the microbial-derived neurotransmitter modulates abdominal pain...
January 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27420311/development-of-subcortical-pitch-representation-in-three-month-old-chinese-infants
#19
Fuh-Cherng Jeng, Chia-Der Lin, Meng-Shih Chou, Grant R Hollister, John T Sabol, Garrett N Mayhugh, Tang-Chuan Wang, Ching-Yuan Wang
This study investigated the development of subcortical pitch processing, as reflected by the scalp-recorded frequency-following response, during early infancy. Thirteen Chinese infants who were born and raised in Mandarin-speaking households were recruited to partake in this study. Through a prospective-longitudinal study design, infants were tested twice: at 1-3 days after birth and at three months of age. A set of four contrastive Mandarin pitch contours were used to elicit frequency-following responses. Frequency Error and Pitch Strength were derived to represent the accuracy and magnitude of the elicited responses...
February 2016: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/27357660/borrowed-alleles-and-convergence-in-serpentine-adaptation
#20
Brian J Arnold, Brett Lahner, Jeffrey M DaCosta, Caroline M Weisman, Jesse D Hollister, David E Salt, Kirsten Bomblies, Levi Yant
Serpentine barrens represent extreme hazards for plant colonists. These sites are characterized by high porosity leading to drought, lack of essential mineral nutrients, and phytotoxic levels of metals. Nevertheless, nature forged populations adapted to these challenges. Here, we use a population-based evolutionary genomic approach coupled with elemental profiling to assess how autotetraploid Arabidopsis arenosa adapted to a multichallenge serpentine habitat in the Austrian Alps. We first demonstrate that serpentine-adapted plants exhibit dramatically altered elemental accumulation levels in common conditions, and then resequence 24 autotetraploid individuals from three populations to perform a genome scan...
July 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
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