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Enrico Mossello, David Simoni
High blood pressure and cognitive impairment often coexist in old age, but their pathophysiological association is complex. Several longitudinal studies have shown that high blood pressure at midlife is a risk factor for cognitive impairment and dementia, although this association is much less clear in old age. The effect of blood pressure lowering in reducing the risk of dementia is only borderline significant in clinical trials of older subjects, partly due to the insufficient follow-up time. Conversely, dementia onset is associated with a decrease of blood pressure values, probably secondary to neurodegeneration...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Carla Gramaglia, Maria Cristina Rizza, Eleonora Gattoni, Eleonora Gambaro, Sarah Di Marco, Isabella Coppola, Annalisa Rossi, Amalia Jona, Fredrica Imperatori, Pierluigi Prosperini, Nunzia Chieppa, Valeria Binda, Serena Farruggio, Elena Grossini, Patrizia Zeppegno
OBJECTIVE: Asenapine, a second-generation antipsychotic, seems to be an effective and tolerable alternative to other treatments for patients with manic or mixed episodes. The objective of our naturalistic observational study was to identify asenapine responders and remitters and to compare responders vs. non-responders and remitters vs. non-remitters, as far as clinical and socio-demographic features are concerned. MATERIALS AND METHODS: We recruited patients with diagnosis of manic episode in bipolar I (BD I) or schizoaffective disorder, with clinical indication to asenapine treatment...
November 2014: Rivista di Psichiatria
Monica Piersanti, Marta Capannolo, Maurizio Turchetti, Nicola Serroni, Domenico De Berardis, Pina Evangelista, Paola Costantini, Antonio Orsini, Alessandro Rossi, Roberto Maggio
BACKGROUND: The purpose of this study was to investigate the risk of death among elderly outpatients (>65 years) with a dementia diagnosis treated with atypical antipsychotics. METHODS: We conducted a cohort study of 696 patients who entered the Unit of Alzheimer Evaluation (UVA) of Teramo Hospital in Central Italy, during a 3-year period (January 2007-December 2009). Among these patients, 375 were treated with atypical antipsychotics (quetiapine, risperidone and olanzapine)...
January 2014: Rivista di Psichiatria
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