Amber K Weiner, Alexander B Radaoui, Matthew Tsang, Daniel Martinez, Simone Sidoli, Karina L Conkrite, Alberto Delaidelli, Apexa Modi, Jo Lynne Rokita, Khushbu Patel, Maria V Lane, Bo Zhang, Chuwei Zhong, Brian Ennis, Daniel P Miller, Miguel A Brown, Komal S Rathi, Pichai Raman, Jennifer Pogoriler, Tricia Bhatti, Bruce Pawel, Tina Glisovic-Aplenc, Beverly Teicher, Stephen W Erickson, Eric J Earley, Kristopher R Bosse, Poul H Sorensen, Kateryna Krytska, Yael P Mosse, Karin E Havenith, Francesca Zammarchi, Patrick H van Berkel, Malcolm A Smith, Benjamin A Garcia, John M Maris, Sharon J Diskin
UNLABELLED: Cancer immunotherapies have produced remarkable results in B-cell malignancies; however, optimal cell surface targets for many solid cancers remain elusive. Here, we present an integrative proteomic, transcriptomic, and epigenomic analysis of tumor specimens along with normal tissues to identify biologically relevant cell surface proteins that can serve as immunotherapeutic targets for neuroblastoma, an often-fatal childhood cancer of the developing nervous system. We apply this approach to human-derived cell lines (N=9) and cell/patient-derived xenograft (N=12) models of neuroblastoma...
December 8, 2023: bioRxiv