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https://www.readbyqxmd.com/read/29435111/impact-of-dlk1-dio3-imprinted-cluster-hypomethylation-in-smoker-patients-with-lung-cancer
#1
Sonia Molina-Pinelo, Ana Salinas, Nicolás Moreno-Mata, Irene Ferrer, Rocío Suarez, Eduardo Andrés-León, Manuel Rodríguez-Paredes, Julian Gutekunst, Eloisa Jantus-Lewintre, Carlos Camps, Amancio Carnero, Luis Paz-Ares
DNA methylation is important for gene expression and genome stability, and its disruption is thought to play a key role in the initiation and progression of cancer and other diseases. The DLK1-DIO3 cluster has been shown to be imprinted in humans, and some of its components are relevant to diverse pathological processes. The purpose of this study was to assess the methylation patterns of the DLK1-DIO3 cluster in patients with lung cancer to study its relevance in the pathogenesis of this disease. We found a characteristic methylation pattern of this cluster in smoking associated lung cancer, as compared to normal lung tissue...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416007/genome-wide-dna-methylation-analysis-reveals-that-mouse-chemical-ipscs-have-closer-epigenetic-features-to-mescs-than-oskm-integrated-ipscs
#2
Wangfang Ping, Jian Hu, Gongcheng Hu, Yawei Song, Qing Xia, Mingze Yao, Shixin Gong, Cizhong Jiang, Hongjie Yao
Induced pluripotent stem cells can be derived from somatic cells through ectopic expression of transcription factors or chemical cocktails. Chemical iPSCs (C-iPSCs) and OSKM-iPSCs (4F-iPSCs) have been suggested to have similar characteristics to mouse embryonic stem cells (mESCs). However, their epigenetic equivalence remains incompletely understood throughout the genome. In this study, we have generated mouse C-iPSCs and 4F-iPSCs, and further compared the genome-wide DNA methylomes of C-iPSCs, 4F-iPSCs, and mESCs that were maintained in 2i and LIF...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29383634/soluble-delta-like-1-homolog-dlk1-stimulates-angiogenesis-through-notch1-akt-enos-signaling-in-endothelial-cells
#3
Chao-Cheng Huang, Hsiao-Mei Kuo, Pei-Chang Wu, Shih-Hsuan Cheng, Tzu-Ting Chang, Yi-Chen Chang, Mei-Lang Kung, Deng-Chyang Wu, Jiin-Haur Chuang, Ming-Hong Tai
AIM: Delta-like 1 homolog (DLK1) is a non-canonical ligand of Notch signaling, which plays a pivotal role in vascular development and tumor angiogenesis. This study aimed to elucidate the function and mechanism of DLK1 in angiogenesis. METHODS AND RESULTS: By using in situ hybridization and immunohistochemical studies, expression analysis revealed a unique vascular tropism of DLK1 in vasculature of neuroblastoma and vascular tumors. Thus, it was hypothesized that DLK1 may be cleaved and then bound to endothelial cells, thereby regulating the endothelial function...
January 30, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29348851/comprehensive-analysis-of-mrna-lncrna-co-expression-profile-revealing-crucial-role-of-imprinted-gene-cluster-dlk1-meg3-in-chordoma
#4
Hao Chen, Kai Zhang, Jian Lu, Guizhong Wu, Huilin Yang, Kangwu Chen
Chordoma is a rare bone tumor with high recurrence rate, but the mechanism of its development is unclear. Long non-coding RNAs(lncRNAs) are recently revealed to be regulators in a variety of biological processed by targeting on mRNA transcription. Their expression profile and function in chordoma have not been investigated yet. In this study, we firstly performed the comprehensive analysis of the lncRNA and coding genes expression analysis with three chordoma samples and three fetal nucleus pulposus tissues...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29346572/analysis-of-experience-regulated-transcriptome-and-imprintome-during-critical-periods-of-mouse-visual-system-development-reveals-spatiotemporal-dynamics
#5
Chi-Lin Hsu, Chih-Hsuan Chou, Shih-Chuan Huang, Chia-Yi Lin, Meng-Ying Lin, Chun-Che Tung, Chun-Yen Lin, Ivan Pochou Lai, Yan-Fang Zou, Neil A Youngson, Shau-Ping Lin, Chang-Hao Yang, Shih-Kuo Chen, Susan Shur-Fen Gau, Hsien-Sung Huang
Visual system development is light-experience dependent, which strongly implicates epigenetic mechanisms in light-regulated maturation. Among many epigenetic processes, genomic imprinting is an epigenetic mechanism through which monoallelic gene expression occurs in a parent-of-origin-specific manner. It is unknown if genomic imprinting contributes to visual system development. We profiled the transcriptome and imprintome during critical periods of mouse visual system development under normal- and dark-rearing conditions using B6/CAST F1 hybrid mice...
January 15, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29337408/maternally-expressed-mir-379-mir-544-cluster-is-dispensable-for-testicular-development-and-spermatogenesis-in-mice
#6
Congcong Cao, Yujiao Wen, Juan Dong, Xiaoli Wang, Weibing Qin, Xunbin Huang, Shuiqiao Yuan
Increasing lines of evidence suggest that miRNAs are closely related to spermatogenesis and male infertility which has aroused widespread concerns.The miR-379/miR-544 locus is the largest known placental mammal-specific miRNA cluster, whose 24 miRNA genes are expressed only from the maternal allele, and located within the high conservation of the imprinted Dlk1â€"Dio3 region.A correct dosage of imprinted genes encoded at the mouse Dlk1-Dio3 genomic interval is essential for embryonic growth and postnatal survival, as well as for muscle growth, skeletal, and neuronal development...
January 16, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29278519/gnrh-dependent-precocious-puberty-manifested-at-the-age-of-14-months-in-a-girl-with-47-xxx-karyotype
#7
Nicos Skordis, Eleana Ferrari, Aria Antoniadou, Leonidas A Phylactou, Pavlos Fanis, Vassos Neocleous
This case report describes a 47,XXX girl who presented very early, at the age of 14 months, with signs of sexual precocity (breast and pubic hair development, menarche) and was finally diagnosed with GnRH dependent precocious puberty with no evidence of underlying central nervous system pathology. Molecular testing did not identify any genetic defect in any of the genes tested (KISS1, KISS1R, DLK1 and the intronless MKRN3). Though previous studies have shown a link between karyotype 47,XXX and precocious puberty, this is the youngest patient reported so far...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29197497/delta-like-homolog1-gata-binding-protein-2-axis-mediates-leptin-inhibition-of-ppar%C3%AE-2-expression-in-hepatic-stellate-cells-in-vitro
#8
Yuanyuan Cheng, Xiaofei Zhu, Fangyun Cheng, Li Ji, Yajun Zhou
AIMS: Peroxisome-proliferator activated receptor γ (PPARγ) plays a pivotal role in inhibition of hepatic stellate cell (HSC) activation, a key step for liver fibrogenesis. Adipocyte-derived hormone leptin has been shown to promote liver fibrosis in murine and human. PPARγ includes two subtypes, PPARγ1 and PPARγ2. Our previous study indicated that leptin down-regulated PPARγ1 expression in HSCs. The aim of this study was to investigate the effect of leptin on PPARγ2 expression and the underlying mechanisms in HSCs...
November 29, 2017: Life Sciences
https://www.readbyqxmd.com/read/29190766/developmental-peculiarities-in-placentae-of-ovine-uniparental-conceptuses
#9
Roberta Arena, Federica Zacchini, Paola Toschi, Luca Palazzese, Marta Czernik, Grażyna Ewa Ptak
Genomic imprinting is an epigenetic phenomenon regulating mono-allelic expression of genes depending on their parental origin. Defective genomic imprinting is involved in several placental disorders, such as intrauterine growth restriction and pre-eclampsia. Uniparental embryos, having maternal-only or paternal-only genomes (parthenogenotes [PAR] and androgenotes [AND], respectively), are useful models to study placentation. The aim of this work was to reveal the effect of parental genome (maternal and paternal) on placentation...
2017: PloS One
https://www.readbyqxmd.com/read/29172709/curcumin-suppresses-in-vitro-proliferation-and-invasion-of-human-prostate-cancer-stem-cells-by-modulating-dlk1-dio3-imprinted-gene-cluster-micrornas
#10
Hu Zhang, Jiajia Zheng, Hongliang Shen, Yongyi Huang, Te Liu, Hao Xi, Chuan Chen
AIMS: Curcumin can suppress human prostate cancer (HuPCa) cell proliferation and invasion. However, it is not known whether curcumin can inhibit HuPCa stem cell (HuPCaSC) proliferation and invasion. MATERIALS AND METHODS: We used methyl thiazolyl tetrazolium and Transwell assays to examine the proliferation and invasion of the HuPCaSC lines DU145 and 22Rv1 following curcumin or dimethyl sulfoxide (control) treatment. The microRNA (miRNA) expression levels in the DLK1-DIO3 imprinted genomic region in the cells and in tumor tissues from patients with PCa were examined using microarray and quantitative PCR...
November 27, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29163181/shengfu-oil-enhances-the-healing-of-full-thickness-scalded-skin-accompanying-the-differential-regulation-of-%C3%AE-catenin-dlk1-and-cox-2
#11
Man-Tang Chen, Yan-Jing Yang, Yu-Sang Li, Xiao-Jun Li, Wei K Zhang, Jin-Ping Wang, Xu Wang, Gui-Hua Tian, He-Bin Tang
Shengfu oil is a traditional Chinese medicine formula containing 16 ingredients, including Scutellariae radix, Olibanum, and Rehmanniae radix. In this study, we aimed to enhance the wound healing of rabbit full-thickness scalded skin by Shengfu oil and to elucidate its regulatory effects on β-catenin, Dlk1, and COX-2. We found that Shengfu oil exhibited significant anti-inflammatory, analgesic, and antimicrobial activities. The structure of wound tissues in Shengfu oil group was intact, including regenerated cutaneous appendages, indicating better healing capability of Shengfu oil compared to the controls...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29159818/c-ebp%C3%AE-dependent-pre-neoplastic-tumor-foci-are-the-origin-of-hepatocellular-carcinoma-and-aggressive-pediatric-liver-cancer
#12
Ashley Cast, Leila Valanejad, Mary Wright, Phuong Nguyen, Anita Gupta, Liqin Zhu, Soona Shin, Nikolai Timchenko
Recent publications show that classic hepatoblastoma (HBL) is the result of failure of hepatic stem cells to differentiate into hepatocytes; while hepatocellular carcinoma (HCC) is caused by the de-differentiation of hepatocytes into Cancer Stem Cells (CSCs). However, the mechanisms of aggressive HBL and mechanisms that cause de-differentiation of hepatocytes into CSCs are unknown. We found that, similar to HCC but opposite to classic HBL, aggressive HBL is the result of de-differentiation of hepatocytes into CSCs...
November 21, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29157033/alteration-in-methylation-level-at-differential-methylated-regions-of-mest-and-dlk1-in-fetus-of-preeclampsia
#13
Xiaoqing Wang, Liuxia Wan, Xiaoling Weng, Jiamin Xie, Aiping Zhang, Yun Liu, Minyue Dong
OBJECTIVES: Offspring born to preeclamptic women are at high risk for metabolic diseases in later life, but the mechanisms are not known. The purposes of the current investigation were to clarify the changes in DNA methylation at MEST and DLK1 DMRs in fetus of preeclampsia and to explore the possible mechanisms behind the high risk of adult diseases in the offspring of preeclampsia. METHODS: Fetal lymphocytes were isolated from umbilical cord blood of 78 women with preeclampsia and 95 women with normal pregnancy...
November 20, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29129685/small-rna-sequencing-reveals-dlk1-dio3-locus-embedded-micrornas-as-major-drivers-of-ground-state-pluripotency
#14
Sharif Moradi, Ali Sharifi-Zarchi, Amirhossein Ahmadi, Sepideh Mollamohammadi, Alexander Stubenvoll, Stefan Günther, Ghasem Hosseini Salekdeh, Sassan Asgari, Thomas Braun, Hossein Baharvand
Ground-state pluripotency is a cell state in which pluripotency is established and maintained through efficient repression of endogenous differentiation pathways. Self-renewal and pluripotency of embryonic stem cells (ESCs) are influenced by ESC-associated microRNAs (miRNAs). Here, we provide a comprehensive assessment of the "miRNome" of ESCs cultured under conditions favoring ground-state pluripotency. We found that ground-state ESCs express a distinct set of miRNAs compared with ESCs grown in serum. Interestingly, most "ground-state miRNAs" are encoded by an imprinted region on chromosome 12 within the Dlk1-Dio3 locus...
November 7, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29069869/potential-applications-of-meg3-in-cancer-diagnosis-and-prognosis
#15
REVIEW
Yuqing He, Yanhong Luo, Biyu Liang, Lei Ye, Guangxing Lu, Weiming He
LncRNAs are emerging as integral functional and regulatory components of normal biological activities and are now considered as critically involved in the development of different diseases including cancer. In this review, we summarized recent findings on maternally expressed gene 3 (MEG3), a noncoding lncRNA, locates in the imprinted DLK1-MEG3 locus on human chromosome 14q32.3 region. MEG3 is expressed in normal tissues but is either lost or decreased in many human tumors and tumor derived cell lines. Studies have demonstrated that MEG3 is associated with cancer initiation, progression, metastasis and chemo-resistance...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29057471/delta-like-2-negatively-regulates-chondrogenic-differentiation
#16
Weifeng Xu, Yexin Wang, Haoming Zhao, Baotin Fan, Ke Guo, Ming Cai, Shanyong Zhang
Delta-like 2 (Dlk2), a glycoprotein highly homologous to Dlk1, belongs to the Notch/Delta/Serrata family. Dlk2 has been shown to be an important regulator of adipogenesis; however, its role in other cellular differentiation processes is still unknown. Therefore, in this study, we aimed to determine the role of Dlk2 in chondrogenic differentiation. We found that Dlk2 overexpression promoted the growth of ATDC5 cells but inhibited insulin-induced ATDC5 chondrogenic differentiation, as supported by the reduction in cartilage matrix formation and gene expression of aggrecan(acan), collagenType II (col2a1) and X (col10a1)...
October 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29054964/gene-expression-profiling-of-the-notch-ahr-il22-axis-at-homeostasis-and-in-response-to-tissue-injury
#17
Marc Weidenbusch, Severin Rodler, Shangqing Song, Simone Romoli, Julian A Marschner, Franziska Kraft, Alexander Holderied, Santosh Kumar, Shrikant R Mulay, Mohsen Honarpisheh, Satish Kumar Devarapu, Maciej Lech, Hans-Joachim Anders
Notch and Interleukin-22 signaling are known to regulate tissue homeostasis and response to injury in humans and mice, and the induction of endogenous arylhydrocarbon receptor ligands through Notch links the two pathways in a hierarchical fashion. However, in adults the species-, organ- and injury-specific gene expression of the Notch-AhR-IL22 axis components is unknown. We therefore performed gene expression profiling of DLL1, DLL3, DLL4, DLK1, DLK2, JAG1, JAG2, Notch1, Notch2, Notch3, Notch4, ADAM17/TACE, PSEN1, BSG/CD147, RBP-J, HES1, HES5, HEY1, HEYL, AHR, ARNT, ARNT2, CYP1A1, CYP24A1, IL22, IL22RA1, IL22RA2, IL10RB, and STAT3 under homeostatic conditions in 10 mature murine and human organs...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29051564/network-analysis-of-emt-and-met-micro-rna-regulation-in-breast-cancer
#18
Diana Drago-García, Jesús Espinal-Enríquez, Enrique Hernández-Lemus
Over the last years, microRNAs (miRs) have shown to be crucial for breast tumour establishment and progression. To understand the influence that miRs have over transcriptional regulation in breast cancer, we constructed mutual information networks from 86 TCGA matched breast invasive carcinoma and control tissue RNA-Seq and miRNA-Seq sequencing data. We show that miRs are determinant for tumour and control data network structure. In tumour data network, miR-200, miR-199 and neighbour miRs seem to cooperate on the regulation of the acquisition of epithelial and mesenchymal traits by the biological processes: Epithelial-Mesenchymal Transition (EMT) and Mesenchymal to Epithelial Transition (MET)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29027534/long-non-coding-rna-meg3-promotes-the-proliferation-of-glioma-cells-through-targeting-wnt-%C3%AE-catenin-signal-pathway
#19
X Gong, M Huang
Glioma has been identified as one of the most aggressive primary tumors. Long non-coding RNAs (lncRNAs), with length larger than 200 bp, have drawn increasing attention to their abnormal expression and regulation function in carcinogenesis. However, the role of lncRNAs in glioma remains largely unknown. Maternally expressed gene 3 (MEG3), also known as gene-trap locus 2 (GTL2), is an imprinted gene, and is encoded by the MEG3 transcript of the DLK1/MEG3 locus on human chromosome, or Meg3 on mouse chromosome...
September 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/29027306/fenton-reaction-induced-renal-carcinogenesis-in-mutyh-deficient-mice-exhibits-less-chromosomal-aberrations-than-the-rat-model
#20
Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26...
October 13, 2017: Pathology International
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