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necrotizing fasciitis

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https://www.readbyqxmd.com/read/29146218/presentation-and-diagnosis-of-fournier-s-gangrene
#1
REVIEW
Bryan B Voelzke, Judith C Hagedorn
Necrotizing fasciitis is a severe type of necrotizing soft tissue infection involving the superficial fascia and subcutaneous tissues. Fournier's gangrene, a type of necrotizing fasciitis, affects the genitalia and/or perineum. While a rare health condition, Fournier's gangrene can result in significant morbidity and unnecessary mortality following delay in diagnosis and management. We provide a review of relevant presenting features to aid diagnosis and allow timely surgical management of this serious infectious condition...
November 13, 2017: Urology
https://www.readbyqxmd.com/read/29145312/bilateral-femoral-posterior-neurocutaneous-perforater-flap-successfully-treating-fournier-gangrene-a-case-report
#2
Tao Wang, Gang Zhao, Yong-Jun Rui, Jing-Yi Mi
RATIONALE: Necrotizing fasciitis (NF), characterized by widespread fascial necrosis, is a rare disease in clinic. Fournier gangrene (FG) is a special type of NF involved of perineum and scrotum. To our knowledge, no article has reported on bilateral femoral posterior neurocutaneous perforater flap treating for FG. PATIENT CONCERNS: A 61-year-old Chinese male complained of perineal skin necrosis for 19 days. The patient received treatment in other hospital due to chronic bronchitis on April 15th and body temperature ranged from 38 to 39 °C...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29124073/first-necrotizing-fasciitis-caused-by-haemophilus-influenza-serotype-a
#3
Giang T Quach, Jared Frisby, Kurt Kralovich, Mustafa Bohra
Necrotizing fasciitis (NF) is an infrequently encountered skin infection that has high morbidity and mortality, even with prompt medical and surgical intervention. We describe the case of a 67-year-old male presenting with significant NF in his left lower extremity, despite aggressive surgical intervention, and included multiple surgical debridements, ACell Matrix, split-thickness, and negative wound VAC therapy. Ultimately, this patient required a below the knee amputation. This is the first documented case of Haemophilus influenza type a causing NF...
October 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29123908/a-case-of-disseminated-cryptococcosis-with-necrotizing-fasciitis-in-a-non-hiv-patient
#4
Tetsuya Hoshino, Kazuya Omura, Shinichi Kimura, Hiroyuki Takahashi, Katsuhiko Kamei, Misako Ohkusu
Case: Disseminated cryptococcosis is a well-recognized condition among HIV patients, but it also occurs in non-HIV patients. Necrotizing fasciitis caused by cryptococcus is rare. An 81-year-old man who had received steroid therapy presented with erythema and pain in his right thigh. After the rapid progression of symptoms and a failure to respond to antibiotic therapy, a clinical diagnosis of necrotizing fasciitis was made. We performed debridement, and yeasts were detected using a Gram stain of the fascia...
October 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122881/whole-genome-sequencing-of-a-human-clinical-isolate-of-emm28-streptococcus-pyogenes-causing-necrotizing-fasciitis-acquired-contemporaneously-with-hurricane-harvey
#5
S Wesley Long, Priyanka Kachroo, James M Musser, Randall J Olsen
We discovered an emm28 Streptococcus pyogenes isolate causing necrotizing fasciitis in a patient exposed to the floodwaters of Hurricane Harvey in the Houston, TX, metropolitan area in August 2017. The Oxford Nanopore MinION instrument provided sufficient genome sequence data within 1 h of beginning sequencing to close the genome.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29108905/-maternal-deaths-due-to-infectious-cause-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#6
A Rigouzzo, V Tessier, L Zieleskiewicz
Over the period 2010-2012, maternal mortality from infectious causes accounted for 5% of maternal deaths by direct causes and 16% of maternal deaths by indirect causes. Among the 22 deaths caused by infection occurred during this period, 6 deaths were attributed to direct causes from genital tract origin, confirming thus the decrease in direct maternal deaths by infection during the last ten years. On the contrary, indirect maternal deaths by infection, from extragenital origin, doubled during the same period, with 16 deaths in the last triennium, dominated by winter respiratory infections, particularly influenza: the 2009-2010 influenza A (H1N1) virus pandemic was the leading cause of indirect maternal mortality by infection during the studied period...
November 3, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29105542/cervical-necrotizing-fasciitis-an-overlooked-diagnosis-of-a-fatal-disease
#7
Mohamed A Al-Ali, Ashraf F Hefny, Kamal M Idris, Fikri M Abu-Zidan
BACKGROUND: Necrotizing fasciitis of the neck is a rare potentially lethal condition if not early diagnosed and managed. We aimed to study the clinical presentation, radiological and microbiological diagnosis, management, and surgical outcome of patients having cervical necrotizing fasciitis (CNF). MATERIALS AND METHODS: We retrospectively studied patients having a final diagnosis of CNF who were treated at Al Ain Hospital during the period of January 2000 to December 2016...
November 6, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29099935/immunoglobulin-attenuates-streptokinase-mediated-virulence-in-streptococcus-dysgalactiae-subsp-equisimilis-necrotizing-fasciitis
#8
Federica Andreoni, Fabio Ugolini, Nadia Keller, Andrina Neff, Victor Nizet, Andrew Hollands, Ewerton Marques Maggio, Annelies S Zinkernagel, Reto A Schuepbach
Necrotizing fasciitis (NF) retains a very high mortality rate despite prompt and adequate antibiotic treatment and surgical debridement. NF has recently been associated with Streptococcus dysgalactiae subsp. equisimilis (SDSE). We investigated the causes of a very severe clinical manifestation of SDSE-NF by assessing both host and pathogen factors. We found a lack of streptokinase-function blocking antibodies in the patient resulting in increased streptokinase-mediated fibrinolysis and bacterial spread. At the same time, the clinical SDSE isolate produced very high levels of streptokinase...
November 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29097860/necrotizing-fasciitis-how-reliable-are-the-cutaneous-signs
#9
REVIEW
Ho Jun Kiat, Yap Hui En Natalie, Lateef Fatimah
Necrotizing fasciitis (NF) is a surgical emergency. It is often aggressive and characterized by the rapidly progressive inflammatory infection of the fascia that causes extensive necrosis of the subcutaneous tissue and fascia, relatively sparing the muscle and skin tissue. As the disease progresses, thrombosis of the affected cutaneous perforators subsequently devascularizes the overlying skin. The course indeed can be a fulminant one. The diagnosis of NF, especially in the early stages, is extremely challenging, and it can be very close in presentation to other skin and subcutaneous tissue infections...
October 2017: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29096338/liver-abscess-and-sepsis-caused-by-clostridium-perfringens-and-klebsiella-oxytoca
#10
Christoph Paasch, Stefan Wilczek, Martin W Strik
INTRODUCTION: Clostridium (C) perfringens and Klebsiella (K) oxytoca are pathogenous human bacteria. Due to the production of several toxins C. perfringens is virulent by causing i.a. the necrotizing fasciitis, gas gangrene and hepatic abscess. K. oxytoca mostly causes infections of the respiratory and gastrointestinal tract. PRESENTATION OF CASE: We are presenting the case of a male patient at the age of 64, who suffered from nausea and progressive pain in the right upper abdomen...
October 26, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29082520/necrotizing-soft-tissue-infections-a-multicentre-prospective-observational-study-infect-protocol-and-statistical-analysis-plan
#11
M B Madsen, S Skrede, T Bruun, P Arnell, A Rosén, M Nekludov, Y Karlsson, F Bergey, E Saccenti, V A P Martins Dos Santos, A Perner, A Norrby-Teglund, O Hyldegaard
BACKGROUND: The INFECT project aims to advance our understanding of the pathophysiological mechanisms in necrotizing soft tissue infections (NSTIs). The INFECT observational study is part of the INFECT project with the aim of studying the clinical profile of patients with NSTIs and correlating these to patient-important outcomes. With this protocol and statistical analysis plan we describe the methods used to obtain data and the details of the planned analyses. METHODS: The INFECT study is a multicentre, prospective observational cohort study...
October 29, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29082050/a-case-of-rituximab-induced-necrotizing-fasciitis-and-a-review-of-the-literature
#12
Abdullateef Abdulkareem, Ryan S D'Souza, Oluwaseun Shogbesan, Anthony Donato
Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29081807/necrotizing-fasciitis-secondary-to-aeromonas-infection-presenting-with-septic-shock
#13
Nikhil Bhatia, Manuel Castro-Borobio, John N Greene, Sowmya Nanjappa
This report describes a case of necrotizing fasciitis presenting with septic shock due to an Aeromonas infection. The patient cut his foot while mowing the lawn and then spent time in a pool with black mold. He began feeling ill and developed swelling and a quarter-sized black area on his right lower extremity. Despite being hemodynamically unstable with systolic blood pressure in the low 70s, the patient was transferred to our facility from outside hospital 100 miles away. Upon arriving to facility, the patient appeared to be septic and the infected area of skin had grown...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29079067/clinical-mimics-an-emergency-medicine-focused-review-of-cellulitis-mimics
#14
Garrett Blumberg, Brit Long, Alex Koyfman
BACKGROUND: Cellulitis is a common clinical condition with low rates of morbidity and mortality if treated appropriately. Mimics of cellulitis presenting with erythema, edema, warmth, and pain can be associated with grave morbidity and mortality if misdiagnosed. OBJECTIVE: This review investigates the signs and symptoms of cellulitis, mimics of cellulitis, and an approach to the management of both cellulitis and its mimics. DISCUSSION: The current emergency medicine definition of cellulitis includes erythema, induration, warmth, and swelling...
October 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29069346/outbreak-of-invasive-infections-from-subtype-emm26-3-group-a-streptococcus-among-homeless-adults-anchorage-alaska-2016-2017
#15
Emily Mosites, Anna Frick, Prabhu Gounder, Louisa Castrodale, Yuan Li, Karen Rudolph, Debby Hurlburt, Kristen D Lecy, Tammy Zulz, Tolu Adebanjo, Jennifer Onukwube, Bernard Beall, Chris A Van Beneden, Thomas Hennessy, Joseph McLaughlin, Bruce Michael
Background: In 2016, we detected an outbreak of group A Streptococcus (GAS) invasive infections among the estimated 1000 persons experiencing homelessness (PEH) in Anchorage, Alaska. We characterized the outbreak and implemented a mass antibiotic intervention at homeless service facilities. Methods: We identified cases through the Alaska GAS laboratory-based surveillance system. We conducted emm-typing, antimicrobial susceptibility testing, and whole genome sequencing (WGS) on all invasive isolates and compared medical record data of patients infected with emm26...
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29052823/can-we-predict-mortality-in-patients-with-necrotizing-fasciitis-using-conventional-scoring-systems
#16
Necdet Fatih Yaşar, Mustafa Ufuk Uylaş, Bartu Badak, Uğur Bilge, Setenay Öner, Enver İhtiyar, Tarık Çağa, Ercüment Paşaoğlu
BACKGROUND: This study compared the predictive accuracy of four scoring systems, namely Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score II (SAPS II), and Mortality in Emergency Department (MEDS), for estimating prognosis in patients with necrotizing fasciitis. METHODS: Seventy-four patients who presented with necrotizing fasciitis were retrospectively examined. The ability of the scoring systems to predict mortality was assessed by comparing the estimated mortality rates in mortality groups (survivors/non-survivors), and mortality rates among survivors and non-survivors with an estimated mortality of >10%, 30%, and 50% in the scoring systems were compared in pairs...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29049264/learning-from-clinical-experience-with-necrotizing-fasciitis-treatment-and-management
#17
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29049258/autologous-platelet-rich-plasma-thrombin-gel-combined-with-split-thickness-skin-graft-to-manage-postinfectious-skin-defects-a-randomized-controlled-study
#18
Barbara Hersant, Mounia SidAhmed-Mezi, Romain Bosc, Jean-Paul Meningaud
BACKGROUND: Managing cutaneous substance loss after debridement is challenging, especially if it is secondary to necrotizing soft tissue infection, such as necrotizing fasciitis and Fournier gangrene. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities. OBJECTIVE: The aim of this study was to investigate whether autologous platelet-rich plasma (A-PRP) could accelerate and improve wound healing after cutaneous reconstruction for tissue loss secondary to soft tissue infection...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29049256/learning-from-clinical-experience-with-necrotizing-fasciitis-treatment-and-management
#19
Yukun Liu, Ke Guo, Jiaming Sun
GENERAL PURPOSE: To provide information about necrotizing fasciitis (NF), how to recognize it, and evidence-based treatment. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: Necrotizing fasciitis is a threatening, rapidly progressive, infectious disease of the soft tissue...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29024965/use-of-pocus-ultrasound-in-sepsis-bedside-diagnosis-of-necrotizing-fasciitis
#20
Joaquín Valle Alonso, Ganapathiram Lakshmanan, Yasser Saleem
No abstract text is available yet for this article.
October 1, 2017: QJM: Monthly Journal of the Association of Physicians
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