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necrotizing fasciitis

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https://www.readbyqxmd.com/read/29322228/-necrotizing-fasciitis-of-the-hand-and-forearm-acute-surgical-treatment-and-defect-reconstruction-with-matriderm%C3%A2-and-split-thickness-skin-graft
#1
B Niedermueller, G Singer, P Pickl, M Jesacher
This case report describes a 55-year-old male patient with type II necrotizing fasciitis (NF) of the hand and forearm. The rapid progression of the tissue infection could be successfully stopped with radical surgical débridement and antibiotic therapy. For the reconstruction of the extensive loss of soft tissue a combination of split-thickness skin graft (STSG) and the synthetic dermal substitute MatriDerm® was used. In cases of NF, MatriDerm® and STSG provide a rapidly available and simple alternative to other reconstruction techniques...
January 10, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29311423/necrotizing-fasciitis-possible-profiles-of-professional-liability-with-reference-to-two-cases
#2
Gian Luca Marella, Enrico De Dominicis, Giovanni Battista Paliani, Giuseppe Santeusanio, Luigi Tonino Marsella, Saverio Potenza
Necrotizing fasciitis is one of the most dangerous complication of an abscess and it is still a disease with a high mortality. In this work, we decided to consider two cases: the first one concerns a male subject, aged 66, deceased because of a fatal necrotizing fasciitis associated to a cervical descending mediastinitis, which evolved from a primary peritonsillar abscess; the second is about a 50-year-old woman with a perineal abscess, then evolved into necrotizing fasciitis associated to a fatal septis shock...
December 18, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29299899/clinical-guidelines-for-the-antibiotic-treatment-for-community-acquired-skin-and-soft-tissue-infection
#3
Yee Gyung Kwak, Seong Ho Choi, Tark Kim, Seong Yeon Park, Soo Hong Seo, Min Bom Kim, Sang Ho Choi
Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. This clinical guideline provides recommendations for the diagnosis and management of SSTI, including impetigo/ecthyma, purulent skin and soft tissue infection, erysipelas and cellulitis, necrotizing fasciitis, pyomyositis, clostridial myonecrosis, and human/animal bite. This guideline targets community-acquired skin and soft tissue infection occurring among adult patients aged 16 years and older...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29282420/rapid-identification-of-pathogens-responsible-for-necrotizing-fasciitis-on-an-integrated-microfluidic-system
#4
Ju-Ching Yu, Pang-Hsin Hsieh, Hsing-Wen Tsai, Wen-Hsin Chang, Ting-Hang Liu, Mel S Lee, Kuo-Ti Peng, Kuo-Chin Huang, Gwo-Bin Lee
Necrotic fasciitis (NF) is a particularly aggressive and serious infection of the fascia that can penetrate into the musculature and internal organs, resulting in death if not treated promptly. In this work, an integrated microfluidic system composed of micropumps, microvalves, and micromixers was used to automate the detection of pathogens associated with NF. The entire molecular diagnostic process, including bacteria isolation, lysis, nucleic acid amplification and optical detection steps, was enacted on this developed system...
November 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/29281989/necrotizing-soft-tissue-infection-clinical-characteristics-and-outcomes-at-a-reconstructive-center-in-jilin-province
#5
Jing-Chun Zhao, Bo-Ru Zhang, Kai Shi, Xi Zhang, Chun-Hui Xie, Jian Wang, Qing-Hua Yu, Xin-Xin Gao, Lei Hong, Jia-Ao Yu
BACKGROUND: To investigate the clinical characteristics and treatment outcomes in necrotizing fasciitis (NF) patients in a reconstructive unit in northeastern China. METHODS: Medical records of patients diagnosed with and treated for NF in the extremities from November 2013 to December 2016 were retrospectively reviewed. Demographic data, clinical presentation, duration of signs and symptoms, location of infection, predisposing factors, causative microbiological organisms, laboratory risk indicator for necrotizing fasciitis (LRINEC) score, number of surgical debridements, length of hospital stay, treatments, and outcomes were recorded...
December 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29278528/treatment-of-severe-skin-and-soft-tissue-infections-a-review
#6
Jason P Burnham, Marin H Kollef
PURPOSE OF REVIEW: To review the salient features of the management of severe skin and soft tissue infections (SSTIs), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis. RECENT FINDINGS: For severe SSTIs, intensive care, source control, and broad-spectrum antimicrobials are required for the initial phase of illness. There is an increasing focus on the utility of rapid diagnostic tests to help in selection and de-escalation of antimicrobials for SSTIs...
December 22, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29250312/severe-fournier-s-gangrene-a-conjoint-challenge-of-gynaecology-and-plastic-surgery
#7
M Wähmann, M Wähmann, F Schütz, C Sohn, S Schott, T Kremer, J F Hernekamp, U Kneser
Necrotizing fasciitis (NF) is a rare soft tissue infection characterized by rapidly progressing necroses and a high mortality. Prompt diagnosis and immediate medical treatment including radical debridement and broad spectrum antibiotics are the key to successful management. We report on a 46-year-old diabetic female who developed extensive, deep necroses in the perineal area and proximal thighs within a few days. After initial gynaecological consultation, she was transferred directly to our department. Due to the suspicion of NF, an immediate radical debridement was performed...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29241843/quantifying-the-effect-of-diabetes-on-surgical-hand-and-forearm-infections
#8
Ketan Sharma, Deng Pan, James Friedman, Jenny L Yu, Aaron Mull, Amy M Moore
PURPOSE: Diabetes has long been established as a risk factor for hand and forearm infections. The purpose of this study was to review the effect of glycemic factors on outcomes among diabetic patients with surgical upper-extremity infections. We hypothesized that diabetic inpatients may benefit from stronger peri-infection glycemic control. METHODS: A prospective cohort study enrolled diabetic and nondiabetic surgical hand and forearm infections over 3 years. Glycemic factors included baseline glycosylated hemoglobin, blood glucose (BG) at presentation, and inpatient BG...
December 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29239728/wound-healing-of-cutaneous-substance-losses-based-on-infectious-inflammatory-and-traumatic-skin-disorders-the-experience-of-a-center
#9
K Khoshim, B Hersant, C Hotz, M SidAhmed-Mezi, J P Meningaud
INTRODUCTION: There is no reference available concerning the standard healing time based on dermatological diseases responsible for cutaneous substance losses. The aim of our study was to assess the healing time after surgical debridement of necrotizing fasciitis (NF), hidradenitis suppurativa (HS) and skin necrosis due to trauma (SNT) based on multiples existing co-morbidities among these patients to provide surgeons with accurate scientific data in order to inform and educate patients and nurses who are practicing care under the supervision of the surgeon...
November 24, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29231774/modern-management-of-diabetic-foot-osteomyelitis-the-when-how-and-why-of-conservative-approaches
#10
Javier Aragón-Sánchez, Benjamin A Lipsky
Diabetic foot osteomyelitis (DFO) has long been considered a complex infection that is both difficult to diagnose and treat, and is associated with a high rate of relapse and limb loss. Areas covered: DFO can usually be diagnosed by a combination of clinical evaluation, serum inflammatory markers and plain X-ray. When the results of these procedures are negative or contradictory, advanced imaging tests or bone biopsy may be necessary. Staphylococcus aureus remains the most frequent microorganism isolated from bone specimens, but infection is often polymicrobial...
December 19, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29229358/thigh-necrotizing-fasciitis-secondary-to-perforated-sigmoid-diverticulitis
#11
Jorge Sancho Muriel, Matteo Frasson, Salvador Pous, Eduardo García-Granero
No abstract text is available yet for this article.
December 8, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29208199/-amputation-of-an-arm-due-to-infection-with-vibrio-vulnificus-after-beach-holiday
#12
Esra Arici, Allan Evald, Dennis Back Holmgaard, Lars Quist, Susanne Dam Poulsen, Signe W Worm
Infection with Vibrio vulnificus is a rare condition with approximately 11 cases reported in the Danish literature. It is characterized by soft tissue infection/wound, necrotizing fasciitis and septicaemia. In this case report we present a patient admitted with a rapid progression and sepsis consistent with V. vulnificus infection but with no informa-tion of water exposure. The initial treatment was surgery and sepsis management including broad-spectrum antibiotics. On day eight the patient's right arm was amputated...
November 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29205142/necrotizing-fasciitis-associated-with-primary-cutaneous-b-cell-lymphoma-a-case-report
#13
K G Spiridakis, D S Intzepogazoglou, M E Flamourakis, E E Sfakianakis, A V Daskalaki, E K Vakonaki, E Rahmanis, G E Kostakis, M S Christodoulakis
Necrotizing fasciitis is a rapidly progressive and life-threatening infection of the deeper skin layers and subcutaneous tissues that moves along the facial planes. OBJECTIVES: We present the rare case of a patient with necrotizing fasciitis associated with high malignancy b-cell lymphoma. Our purpose is to investigate the probable connection between the two pathologies and evaluate the importance of early surgical intervention. CASE REPORT: 51-year old Caucasian woman presented at the E...
May 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29201525/complete-penile-skin-necrosis
#14
Abdulkadir Pektaş, Ali Özgür Karakaş, Ali Çift, Mehmet Özgür Yücel
Superficial penile skin infections may be presented in different clinical situations that vary from simple infection to organ loss and serious morbidity and mortality. Antibiotic treatment and, if necessary, urgent debridement is required. A 46-year-old male patient with the complaints of urethral discharge and pain admitted to our outpatient clinic. He declared that there were midpenil tenderness and erythema 14 days ago which occurred after sexual intercourse. Complete penile skin necrosis with purulent discharge was detected in physical examination...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29184830/orofacial-bacterial-infectious-diseases-an-update
#15
REVIEW
Soussan Irani
Objectives: Most of the oral infections with odontogenic origin are very common and can be treated by tooth extraction, endodontic therapy, or surgical treatment. Other infectious lesions are the manifestations of systemic diseases such as tuberculosis and syphilis. Skin and underlying subcutaneous tissue, fascia, or muscle is also involved with infectious diseases which range from superficial epidermal infections to very serious necrotizing fasciitis. Materials and Methods: An extensive literature in PubMed, Google Scholar, and Scopus search was performed from 1980 to 2017...
October 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29180205/effect-of-transfer-status-on-outcomes-for-necrotizing-soft-tissue-infections
#16
Angela M Ingraham, Hee Soo Jung, Amy E Liepert, Charles Warner-Hillard, Caprice C Greenberg, John E Scarborough
BACKGROUND: Whether patients with necrotizing soft tissue infections (NSTI) who presented to under-resourced hospitals are best served by immediate debridement or expedited transfer is unknown. We examined whether interhospital transfer status impacts outcomes of patients requiring emergency debridement for NSTI. METHODS AND MATERIALS: We conducted a retrospective review studying patients with an operative diagnosis of necrotizing fasciitis, Fournier's gangrene, or gas gangrene in the 2010-2015 American College of Surgeons National Surgical Quality Improvement Program Participant Use Data Files...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29179775/fusobacterium-emphysematous-pyomyositis-with-necrotizing-fasciitis-of-the-leg-presenting-as-compartment-syndrome-a-case-report
#17
Eduardo Smith-Singares, Joseph Adjei Boachie, Izaskun M Iglesias, Leland Jaffe, Adam Goldkind, Eric I Jeng
BACKGROUND: Fusobacterium necrophorum is a common agent of disease in humans, but the occurrence of primary infections outside the head and neck area is extremely rare. While infection with Fusobacterium necrophorum has a rather benign course above the thorax, the organism is capable of producing very severe disease when located in unusual sites, including various forms of septic thrombophlebitis. No infections of the leg have been documented before; thus, antibiotic coverage for Fusobacterium is currently not recommended in this area...
November 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29166257/raoultella-planticola-a-rare-cause-of-wound-infection
#18
Shana S Kalaria, Kristina Elliott, Neal Combs, Linda G Phillips
Raoultella planticola is a gram-negative, aerobic, rod bacterium commonly found in the environment, particularly in water, soil, and fish. This organism has been found to cause a variety of infections, such as necrotizing fasciitis, cystitis, cholecystitis, pancreatitis, hepatic disease, and soft tissue infections. The authors report the case of a 73-year-old-woman who presented with a R planticola wound infection of her left lower extremity after a dog scratch. She was treated successfully with local wound care using dehydrated human amnion/chorion and oral levofloxacin...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29162067/necrotizing-fasciitis-after-high-dose-rate-brachytherapy-and-external-beam-radiation-for-prostate-cancer-a-case-report
#19
Shimpei Yamashita, Yasuo Kohjimoto, Akinori Iba, Kazuro Kikkawa, Isao Hara
BACKGROUND: In recent years, the delayed side effects associated with radiotherapy for prostate cancer have drawn the interest of urologists. Although urosymphyseal fistula is one of these delayed side effects, this serious complication is rarely described in literature and is poorly recognized. CASE PRESENTATION: We report our experience in treating a 77-year-old male patient with necrotizing fasciitis after high-dose rate brachytherapy plus external beam radiation for prostate cancer...
November 21, 2017: BMC Urology
https://www.readbyqxmd.com/read/29158081/streptococcus-pyogenes-nuclease-a-spna-mediated-virulence-does-not-exclusively-depend-on-nuclease-activity
#20
Callum Chalmers, Adrina Hema J Khemlani, Chae Ryeong Sohn, Jacelyn Mei San Loh, Catherine Jia-Yun Tsai, Thomas Proft
BACKGROUND: Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen that causes a wide range of diseases, including pharyngitis, necrotizing fasciitis and toxic shock syndrome. The bacterium produces a large arsenal of virulence factors, including the cell wall-anchored Streptococcus pyogenes nuclease A (SpnA), which facilitates immune evasion by degrading the DNA backbone of neutrophil extracellular traps. SpnA consists of a C-terminal endo/exonuclease domain and a N-terminal domain of unknown function...
November 13, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
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