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https://www.readbyqxmd.com/read/28530316/-radiosurgery-for-pituitary-adenomas
#1
REVIEW
Or Cohen-Inbar
Pituitary adenomas represent one of the most common types of intracranial tumors, accounting for 10-20% of intracranial tumors. While their macroscopic appearance and anatomical location are relatively homogeneous, pituitary tumors differ widely, generating a variety of neurological and endocrine clinical sequelae. Treatment options include hormone suppressive medical therapy, microscopic or endoscopic neurosurgical resection, radiosurgery, radiation therapy, or observation depending on the biochemical profile and the clinical status of the patient...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28530019/men1-in-children-and-adolescents-data-from-patients-of-a-regional-referral-center-for-hereditary-endocrine-tumors
#2
Letizia Vannucci, Francesca Marini, Francesca Giusti, Simone Ciuffi, Francesco Tonelli, Maria Luisa Brandi
PURPOSE: To retrospectively evaluate the age of onset of MEN1-associated lesions in a group of affected children and adolescents and to compare the clinical features of our series with the evidence derived from the literature. METHODS: The study population consisted of 22 Italian children and adolescents (age 6-31 years at the time of the inclusion in this study) all with a clinical and/or a genetic diagnosis of MEN1 performed before the age of 16 who have been followed-up regularly from 1998 to 2016 at the Regional Referral Center for Hereditary Endocrine Tumors...
May 22, 2017: Endocrine
https://www.readbyqxmd.com/read/28523537/prolactinoma-management-predictors-of-remission-and-recurrence-after-dopamine-agonists-withdrawal
#3
Margarida Teixeira, Pedro Souteiro, Davide Carvalho
OBJECTIVE: Prolactinomas are the most common functional pituitary tumour. Dopamine agonists (DA) are its principal treatment. The criteria that should guide therapy withdrawal and the factors that influence disease remission or relapse are not yet fully established. Our purpose is to evaluate the proportion of patients who attempted DA withdrawal, and to identify the factors that influence clinicians to try it. In addition, we aim to study the factors that are involved in prolactinoma remission/relapse after therapy withdrawal...
May 18, 2017: Pituitary
https://www.readbyqxmd.com/read/28520590/role-of-tyrosine-kinase-inhibitors-in-the-treatment-of-pituitary-tumours-from-bench-to-bedside
#4
Anat Ben-Shlomo, Odelia Cooper
PURPOSE OF REVIEW: Treatment of aggressive pituitary tumours often yields suboptimal control of the tumour and confers significant morbidity. Lactotroph and corticotroph-derived tumours express ErbB receptors and ligands, and mutations in ubiquitin-specific protease 8 (USP8), which alters epidermal growth factor receptor (EGFR) degradation, have been implicated in Cushing disease pathogenesis. EGFR tyrosine kinase inhibitor (TKI) therapy has emerged as a potential new therapeutic approach for patients with aggressive prolactinomas and Cushing disease...
May 17, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28511976/fertility-pregnancy-and-prolactinoma-a-survey-of-pituitary-surgeons-view-and-review-of-the-literature
#5
Walter C Jean, Daniel R Felbaum
OBJECTIVE: Pituitary surgeons frequently encounter female prolactinoma patients seeking treatment to restore fertility. Current medical guidelines recommend using dopamine agonist (DA) for this, but for fetal safety, DA should stop upon pregnancy confirmation. The probability that prolactinoma may grow during pregnancy makes this last recommendation imperfect. With the advances in endoscopic surgery, we queried the potential role for surgery in these infertile patients, who may be ambivalent about both stopping and continuing DA while pregnant...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28502303/-effect-of-metformin-on-proliferation-and-apoptosis-of-rat-prolactinoma-mmq-cells-and-related-mechanisms
#6
Kai Jin, Lunliang Ruan, Jiujun Pu, Ailing Zhong, Fuchao Wang, Song Tan, Hua Huang, Jiamin Mou, Gang Yang
Objective To investigate the effect of metformin on the cell proliferation, cell cycle and apoptosis of rat prolactinoma MMQ cells in vitro and related molecular mechanisms. Methods The MMQ cells were treated with 1.25, 2.5, 5, 10, 20 mmol/L metformin for 48 hours. CCK-8 assay was used to assess the cell proliferation ability; flow cytometry was used to analyze the cell cycle distribution and apoptosis; Western blotting was performed to detect the expressions of AMPKα1/2, p-AMPKα, mTOR, p-mTOR, insulin like growth factor 1 receptor (IGF-1R), ERK1/2, p-ERK1/2, AKT, p-AKT, P21, CDK4, cyclin D1, caspase-3, cleaved caspase-3(c-caspase-3), Bcl-2 and BAX...
May 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28501857/combined-treatment-with-artesunate-and-bromocriptine-has-synergistic-anticancer-effects-in-pituitary-adenoma-cell-lines
#7
Xin Wang, Qiu Du, Zhigang Mao, Xiang Fan, Bin Hu, Zhen Wang, Zhiyong Chen, Xiaobing Jiang, Zongming Wang, Ni Lei, Haijun Wang, Yonghong Zhu
Prolactinomas are the most prevalent functional pituitary adenomas. The preferred treatments for prolactinomas are dopamine agonists (DAs) such as bromocriptine (BRC), but DAs still have the challenges of tumor recurrence and drug resistance. This study demonstrates that the synergy of function and mechanism between artesunate (ART) and BRC inhibits prolactinoma cell growth in vitro. We found that low-dose ART combined with BRC synergistically inhibited the growth of GH3 and MMQ cell lines, caused cell death, attenuated cell migration and invasion, and suppressed the expression of extracellular prolactin...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28452619/comparison-of-mri-techniques-for-detecting-microadenomas-in-cushing-s-disease
#8
Yuval Grober, Hagit Grober, Max Wintermark, John A Jane, Edward H Oldfield
OBJECTIVE Many centers use conventional and dynamic contrast-enhanced MRI (DMRI) sequences in patients with Cushing's disease. The authors assessed the utility of the 3D volumetric interpolated breath-hold examination, a spoiled-gradient echo 3D T1 sequence (SGE) characterized by superior soft tissue contrast and improved resolution, compared with DMRI and conventional MRI (CMRI) for detecting microadenomas in patients with Cushing's disease. METHODS This study was a blinded assessment of pituitary MRI in patients with proven Cushing's disease...
April 28, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28450934/microscopic-surgery-for-pituitary-adenomas-to-preserve-the-pituitary-gland-and-stalk
#9
Hao-Yu Li, Cheng-Yuan Feng, Chi Zhang, Jun Su, Jian Yuan, Yuanyang Xie, Yiwei Liao, Xianrui Yuan, Qing Liu
Surgery is the primary treatment of choice for all symptomatic pituitary adenomas except prolactinomas. Common postoperative complications include endocrinopathies, vision impairment and cerebrospinal fluid leak. The present study assessed 153 continuous microscopic surgeries for pituitary adenomas performed by an author of the present study between 2010 to 2014. Patients underwent either transphenoidal or transcranial surgery depending on their individual tumor characteristics. Five typical cases are presented in the present study and intraoperative identification and preservation of the gland and stalk were discussed...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28450229/endoscopic-endonasal-surgery-for-tumors-of-the-cavernous-sinus-a-series-of-234-patients
#10
Maria Koutourousiou, Francisco Vaz Guimaraes Filho, Juan C Fernandez-Miranda, Eric W Wang, S Tonya Stefko, Carl H Snyderman, Paul A Gardner
BACKGROUND: Cavernous sinus (CS) tumors are often considered inoperable. We present our experience with endoscopic endonasal surgery (EES) and compare the outcomes for different tumor. METHODS: EES (medial or lateral approach) was used in 234 patients with CS tumors. The cohort included 175 (75%) pituitary adenomas and 59 (25%) non-adenomatous lesions. RESULTS: Presenting symptoms were significantly different between the two groups, with cranial neuropathies occurring mainly in non-adenomas (p<...
April 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28438863/the-role-of-p16-and-mdm2-gene-polymorphisms-in-prolactinoma-mdm2-gene-polymorphisms-may-be-associated-with-tumor-shrinkage
#11
Seda Turgut, Muzaffer Ilhan, Saime Turan, Ozcan Karaman, Ilhan Yaylim, Ozlem Kucukhuseyin, Ertugrul Tasan
AIM: Prolactinomas are thought to arise from clonal expansion of a single mutated cell which is subjected to growth stimuli of several permissive factors, although the pathogenetic mechanisms underlying tumorigenesis remain unclear. The present study aimed to investigate the role of p16 (540C→G and 580C→T) and mouse double minute 2 (MDM2) (SNP309T→G) gene polymorphisms in tumorigenesis and characteristics of prolactinoma. PATIENTS AND METHODS: A total of 74 patients with prolactinoma and 100 age- and gender-matched healthy individuals were enrolled in the study...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28434012/clinical-importance-of-somatostatin-receptor-2-sstr2-and-somatostatin-receptor-5-sstr5-expression-in-thyrotropin-producing-pituitary-adenoma-tshoma
#12
Benxia Yu, Zhongsheng Zhang, Hao Song, Yuchun Chi, Chunling Shi, Miao Xu
BACKGROUND Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism. Somatostatin analogs have proved to be effective for inhibiting pituitary hormones secretion, working via interactions with somatostatin receptors (SSTRs). Moreover, antiproliferative activity of somatostatin analog is now demonstrated in several studies. In the present study, we determined the relative predominance of SSTR2 and SSTR5 subtypes among the different types of adenomas, especially TSHoma, and investigated the relationship between efficacy of short-term octreotide (OCT) treatment and SSTR expression...
April 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28432860/high-ki-67-expression-is-associated-with-prolactin-secreting-pituitary-adenomas
#13
Bogdan Bălinişteanu, Anca Maria Cîmpean, Amalia Raluca Ceauşu, Ana Silvia Corlan, Eugen Melnic, Marius Raica
Pituitary adenomas represent the third most common primary intracranial tumor in neurosurgical practice. To understand the biological behaviour of the pituitary adenomas previous studies have determined the tumor proliferation rate using monoclonal antibodies targeted against the Ki-67 antigen. The aim of this study was to correlate the Ki-67 index with hormonal profiles of pituitary adenomas. The study included 50 pituitary adenoma cases. For histopathologic evaluation, the sections were stained with routine hematoxylin and eosin method...
April 22, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28411401/expression-of-stem-cell-markers-and-dopamine-d2-receptors-in-human-and-rat-prolactinomas
#14
Zhichao Gao, Lin Cai, Jianglong Lu, Chengde Wang, Qun Li, Jian Chen, Xiaoxiao Song, Xianbin Chen, Linlin Zhang, Weiming Zheng, Zhipeng Su
BACKGROUND Dopamine agonists (DAs) are the first-line treatment for prolactinomas. DAs primarily target the dopamine D2 receptor (D2R). Tumor stem-like cells (TSLCs) are associated with the tolerance to radiotherapy and chemotherapy. TSLCs have also been identified in pituitary adenomas. We aimed to characterize the expression pattern of stem cell markers and D2R in human and rat prolactinomas. MATERIAL AND METHODS Human prolactinoma specimens (n=14) were obtained from patients with surgical resection. The xenograft model of rat prolactinomas was generated by endermically injecting MMQ cells, HE and PRL were confirmed by immunohistochemical staining of tumor sections, and the expression of serum PRL was measured by ELISA...
April 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28396166/paeoniflorin-and-liquiritin-two-major-constituents-in-chinese-herbal-formulas-used-to-treat-hyperprolactinemia-associated-disorders-inhibits-prolactin-secretion-in-prolactinoma-cells-by-different-mechanisms
#15
Yuanyi Wei, Lei La, Lili Wang, Robert Batey, Yuhao Li, Chunxia Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Paeoniflorin and liquiritin are major constituents in some Chinese herbal formulas, such as Yiru Tiaojing (YRTJ) Granule (a hospitalized preparation) and Peony-Glycyrrhiza Decoction, used for hyperprolactinemia-associated disorders. AIM OF THE STUDY: To investigate the effect of paeoniflorin and liquiritin on prolactin secretion. MATERIALS AND METHODS: The effect of YRTJ Granule on metoclopramide-induced hyperprolactinemia was tested in rats...
April 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28390436/n-myc-downstream-regulated-gene-2-ndrg2-promoter-methylation-and-expression-in-pituitary-adenoma
#16
Paulina Vaitkiene, Indre Valiulyte, Brigita Glebauskiene, Rasa Liutkeviciene
BACKGROUND: Pituitary adenoma (PA) is a benign primary tumor that arises from the pituitary gland and is associated with ophthalmological, neurological and endocrinological abnormalities. However, causes that increase tumor progressing recurrence and invasiveness are still undetermined. Several studies have shown N-myc downstream regulated gene 2 (NDRG2) as a tumor suppressor gene, but the role of NDRG2 gene in pituitary adenoma pathogenesis has not been elucidated. The aim of our research has been to examine NDRG2 mRNA expression in PA and to determine the associations between the NDRG2 gene epigenetic changes and the development of recurrence or invasiveness of PA and patient clinical data...
April 8, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28383413/progressive-visual-disturbance-and-enlarging-prolactinoma-caused-by-melanoma-metastasis-a-case-report-and-literature-review
#17
REVIEW
Chuanwei Yang, Ling Liu, Xiaoqiang Lan, Shiqiang Zhang, Xinyu Li, Bo Zhang
RATIONALE: Melanoma metastases to the pituitary adenoma (MMPA) are extremely rare, with only 1 reported case. To date, the melanoma metastasis to the existing prolactinoma has not been reported in literatures. PATIENT CONCERNS: We report a case of 62-year-old woman presented with progressive visual disturbance and hyperprolactinemia. Magnetic resonance imaging demonstrated the presence of a round sellar mass. DIAGNOSES: Melanoma metastasis to the pituitary adenoma...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28377557/expression-of-ghrelin-and-ghrelin-functional-receptor-ghsr1a-in-human-pituitary-adenomas
#18
Mirosław Andrusiewicz, Hanna Komarowska, Izabela Skibińska, Małgorzata Chmielewska, Magdalena Jaskuła-Świtek, Włodzimierz Liebert, Ryszard Waśko, Małgorzata Kotwicka
INTRODUCTION    Pituitary adenomas are heterogenous lesions commonly observed in the central nervous system. Signal transduction of ghrelin, an endogenous ligand specific for growth hormone secretagogue receptor (GHSR), has been reported to be involved in the development of endocrine tumors. However, there are limited data concerning the role of ghrelin and its functional receptor in pituitary adenomas. OBJECTIVES    The aim of the study was to establish the expression pattern of GHRL and its functional receptor GHSR1a in human pituitary adenomas...
March 31, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28351913/management-of-endocrine-disease-quality-of-life-tools-for-the-management-of-pituitary-disease
#19
REVIEW
Susan M Webb, Iris Crespo, Alicia Santos, Eugenia Resmini, Anna Aulinas, Elena Valassi
BACKGROUND: In the last few years, quality of life (QoL) has become an outcome measure in patients with pituitary diseases. OBJECTIVE: To describe the available data on QoL impairment evaluated with questionnaires in patients with pituitary diseases. DESIGN: Critical review of the pertinent literature and pragmatic discussion of available information. METHODS: Selection of relevant literature from PubMed and WOK, especially from the last 5 years and comprehensive analysis...
July 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28346715/cabergoline-related-impulse-control-disorder-in-an-adolescent-with-a-giant-prolactinoma
#20
LETTER
C Bulwer, R Conn, A Shankar, F Ferrau, S Kapur, A Ederies, M Korbonits, H A Spoudeas
No abstract text is available yet for this article.
March 27, 2017: Clinical Endocrinology
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