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https://www.readbyqxmd.com/read/28321375/cost-effectiveness-analysis-of-surgical-versus-medical-treatment-of-prolactinomas
#1
Corinna C Zygourakis, Brandon S Imber, Rebecca Chen, Seunggu J Han, Lewis Blevins, Annette Molinaro, James G Kahn, Manish K Aghi
Background Few studies address the cost of treating prolactinomas. We performed a cost-utility analysis of surgical versus medical treatment for prolactinomas. Materials and Methods We determined total hospital costs for surgically and medically treated prolactinoma patients. Decision-tree analysis was performed to determine which treatment produced the highest quality-adjusted life years (QALYs). Outcome data were derived from published studies. Results Average total costs for surgical patients were $19,224 ( ± 18,920)...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28321344/pituitary-adenoma-and-hyperprolactinemia-accompanied-by-idiopathic-granulomatous-mastitis
#2
Sebahattin Destek, Vahit Onur Gul, Serkan Ahioglu, Kursat Rahmi Serin
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of the breast, and its etiology remains not fully elucidated. IGM is observed more often in patients with autoimmune disease. Hyperprolactinemia is observed during pregnancy, lactation, and a history of oral contraceptive use. A 39-year-old patient with no history of oral contraceptive use presented with complaints such as redness, pain, and swelling in her left breast. Ultrasound and magnetic resonance imaging (MRI) revealed a suspicious inflamed mass lesion...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28278079/breast-carcinoma-associated-with-prolactinoma-a-case-report
#3
Yurong Zheng, Wenju Mo, Yang Yu, Dehong Zou, Xiangming He, Xianghou Xia, Jiejie Hu
We report a 28-year-old woman who presented with a 6-year history of milk-like discharge from both of her nipples and was diagnosed with prolactinoma based on computed tomography (CT) findings and serum prolactin level. Further breast examination revealed a mass located in the upper outer region of the left breast. She underwent subtotal pituitary tumor resection. Thereafter, modified radical mastectomy was performed for left breast cancer. Twelve years after treatment, prolactinoma recurrence was detected, and bromocriptine therapy was administered...
February 17, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28259983/therapeutic-effects-of-schisandra-chinensis-on-the-hyperprolactinemia-in-rat
#4
So-Hye Hong, Mei Li, Eui-Bae Jeung, Geun-Shik Lee, Eui-Ju Hong, Young-Whan Choi, Beum-Soo An
Prolactin (PRL) is secreted from the pituitary gland in response to eating, mating, and ovulation. Increased serum concentration of PRL during pregnancy contributes to enlargement of the mammary glands of the breasts and prepares for production of milk. However, high PRL levels derived from prolactinoma and hyperprolactinemia induce physiological disorders such as infertility and early menopause. Natural compounds isolated from S. chinensis have been known to possess anti-oxidative, anti-inflammatory and anti-diabetic effects...
February 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28238271/clozapine-treatment-for-cabergoline-induced-psychosis-in-a-patient-with-a-giant-prolactinoma
#5
Rodrigo Pérez-Esparza, Carlos Alberto Rojas-Guerrero, Gerson Geovany Andino-Rios, Patricia Arias-Garro, Jesús Ramírez-Bermúdez, Lesly Portocarrero-Ortiz
No abstract text is available yet for this article.
February 27, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28217516/long-term-cardiac-valvulopathy-safety-of-cabergoline-in-prolactinoma
#6
Shruti Khare, Anurag R Lila, Rishikesh Patil, Milind Phadke, Prafulla Kerkar, Tushar Bandgar, Nalini S Shah
BACKGROUND: Clinical relevance of association of cabergoline use for hyperprolactinemia and cardiac valvulopathy remains unclear. OBJECTIVE: The aim of the study was to determine the prevalence of valvular heart abnormalities in patients taking cabergoline for the treatment of prolactinoma and to explore any associations with the cumulative dose of drug used. DESIGN: A cross-sectional echocardiographic study was performed in patients who were receiving cabergoline therapy for prolactinoma...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28197925/giant-prolactinoma-presenting-as-a-base-of-skull-tumor-with-nasopharyngeal-extension-a-potential-diagnostic-pitfall-in-neuroendocrine-lesions-of-the-base-of-skull
#7
Amy Prawira, Dorothy Lazinski, Lillian L Siu, Bayardo Perez-Ordonez
Pituitary adenomas presenting in uncommon anatomical locations are commonly misdiagnosed. Dramatic clinical presentation with hemorrhage and infarction, along with a lack of endocrine symptoms may further confound the diagnosis in some patients as illustrated in one of our two previously reported cases of non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. This report presents the clinical progress of case number 2, which has a revised diagnosis of giant lactotroph pituitary adenoma...
February 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28170483/diagnosis-and-treatment-of-pituitary-adenomas-a-review
#8
REVIEW
Mark E Molitch
Importance: Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are important. Observations: Prevalence of pituitary adenomas ranges from 1 in 865 adults to 1 in 2688 adults. Approximately 50% are microadenomas (<10 mm); the remainder are macroadenomas (≥10 mm). Mass effects cause headache, hypopituitarism, and visual field defects. Treatments include transsphenoidal surgery, medical therapies, and radiotherapy...
February 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28163656/global-expression-profile-of-tumor-stem-like-cells-isolated-from-mmq-rat-prolactinoma-cell
#9
Zhipeng Su, Lin Cai, Jianglong Lu, Chuzhong Li, Songbai Gui, Chunhui Liu, Chengde Wang, Qun Li, Qichuan Zhuge, Yazhuo Zhang
BACKGROUND: Cancer stem cells (CSCs), which have been isolated from various malignancies, were closely correlated with the occurrence, progression, metastasis and recurrence of the malignant cancer. Little is known about the tumor stem-like cells (TSLCs) isolated from benign tumors. Here we want to explore the global expression profile of RNA of tumor stem-like cells isolated from MMQ rat prolactinoma cells. METHODS: In this study, total RNA was extracted from MMQ cells and MMQ tumor stem-like cells...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28160129/hypersexuality-in-men-with-prolactinomas-treated-with-dopamine-agonists
#10
EDITORIAL
Irina Bancos, Todd B Nippoldt, Dana Erickson
No abstract text is available yet for this article.
February 4, 2017: Endocrine
https://www.readbyqxmd.com/read/28145933/an-economic-analysis-of-bromocriptine-versus-trans-sphenoidal-surgery-for-the-treatment-of-prolactinoma
#11
Lian Duan, Hua Yan, Minqiang Huang, Yuhui Zhang, Feng Gu
Prolactinomas account for ∼40% of all pituitary adenomas and are important causes of infertility and gonadal dysfunction. In general, most prolactinomas are treated medically with dopaminergic agonists, while surgery is reserved for patients intolerant or nonresponsive to these medications. The aim of this study was to carry out a comparative analysis of the cost-effectiveness of medical therapy with bromocriptine and surgical therapy with trans-sphenoidal surgery. A Markov model was developed based on retrospective data from 126 patients with prolactinoma treated in our hospital between October 2008 and May 2009, and from data published previously...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28144772/a-combined-opiate-agonist-and-antagonist-treatment-reduces-prolactin-secreting-pituitary-tumor-growth
#12
George Maglakelidze, Olivia Wynne, Dipak K Sarkar
Prolactin secreting pituitary adenomas (prolactinomas) is the most common pituitary tumors in humans. Animal studies have identified aggressive prolactinoma development in fetal alcohol exposed rats. We have recently identified a combination treatment of a μ opioid receptor antagonist naltrexone and a δ opioid receptor agonist D-Ala2-,N-Me-Phe4,Gly-ol Enkephalin (DPDPE) increases innate immune function. In this study, we tested whether naltrexone and DPDPE combination therapy is useful to control pituitary tumor growth...
January 31, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28137551/bromocriptine-induces-autophagy-dependent-cell-death-in-pituitary-adenomas
#13
Xin Geng, Lixin Ma, Zefu Li, Zhenzhu Li, Jianmin Li, Meng Li, Qingbo Wang, Zheng Chen, Qikai Sun
BACKGROUND: Bromocriptine(BRC) is effective in patients with prolactinoma. However, the cytotoxic mechanism of BRC remains unknown. METHODS: Slices for immunohistochemical pathology were randomly selected from 37 paraffin-embedded prolactinoma tissue sections. LC3 was detected by immunohistochemistry. GH3 and MMQ cells were treated by BRC and/or rapamycin (RAPA). Cell viability and the cell cycle were measured by CCK-8 and flow cytometry, respectively. ELISA measured prolactin secretion...
January 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28127130/endovascular-therapy-using-flow-diversion-for-giant-internal-carotid-artery-pseudoaneurysm-arising-in-the-setting-of-an-invasive-pituitary-macroadenoma
#14
Amin F Saad, Almas Syed, Keyan B Marashi, Brian D O'Rourke, Joseph H Hise, Michael J Opatowsky, Kennith F Layton
This report illustrates the unusual occurrence of a pseudoaneurysm arising in the setting of a skull base mass and describes the first reported use of endovascular flow diversion therapy in such a setting. A 63-year-old man with occasional headaches during the preceding month presented with the acute onset of severe left retroorbital headache and oculomotor nerve palsy. Computed tomography (CT) and CT angiogram revealed a destructive skull base mass with an associated giant probable pseudoaneurysm of the cavernous segment of the left internal carotid artery...
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28120110/identification-of-m2-macrophages-in-anterior-pituitary-glands-of-normal-rats-and-rats-with-estrogen-induced-prolactinoma
#15
Ken Fujiwara, Megumi Yatabe, Alimuddin Tofrizal, Depicha Jindatip, Takashi Yashiro, Ryozo Nagai
Macrophages are present throughout the anterior pituitary gland. However, the features and function of macrophages in the gland are poorly understood. Recent studies have indicated that there are two main macrophage classes: M1 (classically activated) and M2 (alternatively activated). In this study, we examine whether both M1 and M2 macrophages are present in the anterior pituitary gland of rats. Our findings indicate that macrophages that are positive for CD68 (a pan-macrophage marker) were localized near capillaries in rat anterior pituitary gland...
January 24, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28110235/relationship-between-expression-of-vascular-endothelial-growth-factor-and-the-proliferation-of-prolactinomas
#16
Nan Li Ya, ZhiQuan Jiang
OBJECTIVE: Prolactinomas are the most common functional hormone-producing pituitary lesions, accounting for 30-40% of all pituitary tumors, while in autopsy series their incidence reaches 50%. However, patients with prolactinoma had a higher recurrence percentage and rate than patients with acromegaly or Cushing's disease. Furthermore, prolactinomas have the highest rate of recurrence post-surgery as compared with other pituitary adenomas. At present, this behavior of prolactinoma is largely unexplained, but may be related to definition of cure, or to more frequent microscopic tumor infiltration into normal pituitary tissue, which is not removed at surgery...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28096982/the-birth-and-rise-of-a-craniopharyngioma-the-radiological-evolution-of-an-incidental-craniopharyngioma-detected-on-serial-mri-during-medical-treatment-of-a-macroprolactinoma
#17
Stefano Mariotti, Marco Losa, Pietro Mortini, Luca Saba
This case demonstrates the rare coexistence of a prolactinoma with craniopharyngioma and documents its radiological growth. This case suggests that patients with pituitary neoplasms should be followed closely and although prolactinomas can often be managed medically, a coexistent other lesion may require surgery for histological assessment and to reduce mass effect.
January 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28096433/sex-differences-in-the-development-of-prolactinoma-in-mice-overexpressing-hcg%C3%AE-role-of-tgf%C3%AE-1
#18
Erika Y Faraoni, María Andrea Camilletti, Alejandra Abeledo-Machado, Laura D Ratner, Fernanda De Fino, Ilpo Huhtaniemi, Susana B Rulli, Graciela Díaz-Torga
Female transgenic mice that overexpress the human chorionic gonadotrophin β subunit (hCGβ+) develop prolactinomas, whereas hCGβ+ males do not. The high levels of circulating hCG induce massive luteinization in the ovary of hCGβ+ females, and progesterone becomes the primary steroid hormone produced, but estradiol remains at physiological level. The involvement of high levels of progesterone in lactotroph proliferation is not clearly understood; hence, the pathogenesis of prolactinomas in hCGβ+ females remains unclear...
March 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28089836/delayed-csf-rhinorrhea-after-gamma-knife-radiosurgery-with-or-without-preceding-transsphenoidal-resection-for-pituitary-pathology
#19
Avital Perry, Christopher S Graffeo, William R Copeland, Kathryn M Van Abel, Matthew L Carlson, Bruce E Pollock, Michael J Link
BACKGROUND: Skull base cerebrospinal fluid (CSF) leak after gamma knife radiosurgery (GKRS) is a very rare complication. In patients who were treated with both GKRS and transsphenoidal resection (TSR) for pituitary lesions, early CSF leak occurs at a comparable rate to the general TSR population (4%). Delayed CSF leak occurring more than a year after TSR, GKRS, or dual therapy, is exceedingly rare. METHODS: Retrospective chart review and review of the literature RESULTS: We present two cases of delayed CSF leak following GKRS to treat pituitary adenoma...
January 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28079813/surgical-treatment-for-male-prolactinoma-a-retrospective-study-of-184-cases
#20
Yi-Jun Song, Mei-Ting Chen, Wei Lian, Bing Xing, Yong Yao, Ming Feng, Ren-Zhi Wang
A total of 184 cases of surgically treated male prolactinoma were analyzed retrospectively to summarize the outcome of this surgical intervention. We analyzed the general characteristics, clinical manifestations, hormone levels, imaging features, preoperative treatments, surgical outcomes, pathology results, and follow-up records for all included patients. The most common clinical manifestations included sexual dysfunction (47.4%), headache (55.9%), and visual disturbance (46.7%). Serum prolactin levels ranged from 150 to 204,952 ng/mL...
January 2017: Medicine (Baltimore)
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