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Acromegaly

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https://www.readbyqxmd.com/read/28316158/-cost-effectiveness-analysis-of-octreotide-long-acting-release-and-lanreotide-slow-release-for-the-treatment-of-postoperative-patients-with-active-acromegaly-in-china
#1
J W Xuan, Z Y Zhang, Y F Wang, Z G Mao, Y J Lu, R Z Wang
Objective: To evaluate the cost-effectiveness of octreotide long acting release (LAR) vs lanreotide slow release (SR) for the treatment of postoperative acromegalic patients with elevated levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in China. Methods: A decision tree model was constructed and the treatment impact was projected for one year in Chinese setting. The clinical efficacy measure used was the percentage of patients achieving normalization (control) of either IGF-1 or GH levels...
March 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28316090/impaired-quality-of-life-in-patients-with-treated-acromegaly-despite-long-term-biochemically-stable-disease-results-from-a-5-year-prospective-study
#2
Nikolaos Kyriakakis, Julie Lynch, Stephen G Gilbey, Susan M Webb, Robert D Murray
OBJECTIVE: Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN: The study consists of a cross-sectional arm comparing QoL between patients with treated and controlled acromegaly and healthy controls; and a longitudinal arm assessing QoL changes in patients with biochemically stable disease during 5...
March 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28301972/efficacy-of-transsphenoidal-surgery-in-achieving-biochemical-cure-of-growth-hormone-secreting-pituitary-adenomas-among-patients-with-cavernous-sinus-invasion-a-systematic-review-and-meta-analysis
#3
Vanessa Briceno, Hasan A Zaidi, Joanne A Doucette, Kaho B Onomichi, Amer Alreshidi, Rania A Mekary, Timothy R Smith
OBJECTIVES: Growth hormone-secreting pituitary adenomas in adults can result in severe craniofacial disfigurement and potentially fatal medical complications. Surgical resection leading to remission of the disease is dependent on complete surgical resection of the tumor. Lesions that invade the cavernous sinus may not be safely accessible via an endonasal transsphenoidal surgery (TSS), and the rates of biochemical remission of patients with residual disease vary widely in the literature...
March 16, 2017: Neurological Research
https://www.readbyqxmd.com/read/28292926/management-of-endocrine-disease-acromegaly-and-pregnancy-a-contemporary-review
#4
Julio Abucham, M D Bronstein, Monike Lourenço Dias
Although fertility is frequently impaired in women with acromegaly, pregnancy is apparently becoming more common due to improvement in acromegaly treatment as well as in fertility therapy. As a result, several studies on pregnancy in patients with acromegaly have been published in recent years adding new and relevant information to the preexisting literature. Also, new GH assays with selective specificities and the knowledge of the expression of the various GH genes have allowed a better understanding of somatotrophic axis function during pregnancy...
March 14, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28291214/-modern-diagnosis-and-postoperative-monitoring-of-acromegaly-patients-at-a-neurosurgical-clinic
#5
L I Astaf'eva, P L Kalinin, B A Kadashev
Acromegaly is a severe disease associated with chronic overproduction of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1), which is caused in most cases by pituitary adenoma. The main causes of mortality in acromegaly are cardiovascular diseases, respiratory diseases, and cancers. At present, the most effective treatment for acromegaly is surgical pituitary adenomectomy. Complete resection of pituitary tumors leads to the normalization of GH and IGF-1 levels, regression of symptoms, and a reduction in the risk of death...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28279554/a-case-of-coexistence-of-tsh-gh-secreting-pituitary-tumor-and-papillary-thyroid-carcinoma-challenges-in-pathogenesis-and-management
#6
Phatharaporn Kiatpanabhikul, Shanop Shuangshoti, Kraisri Chantra, Patpong Navicharern, Kanaungnit Kingpetch, Natnicha Houngngam, Thiti Snabboon
Co-existence of thyrotropin/growth hormone-secreting pituitary adenoma with differentiated thyroid carcinoma is exceedingly rare, with less than 15 cases having been reported. Its clinical presentation and treatment strategy are challenging. We report a case of pituitary macroadenoma, with clinical syndromes of acromegaly and hyperthyroidism, and a thyroid nodule, with cytologically confirmed to be a papillary thyroid carcinoma. Clinical implications, focusing on the strategy for proper management, and possible pathogenesis were discussed...
March 6, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28279153/the-association-between-biochemical-control-and-cardiovascular-risk-factors-in-acromegaly
#7
John D Carmichael, Michael S Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P Neary, Vivien Bonert
BACKGROUND: The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors. METHODS: Data were from a single-center acromegaly registry. Study patients were followed for ≥12 months after initial treatment. Study period was from first to last insulin-like growth factor-I and growth hormone tests. RESULTS: Of 121 patients, 55% were female...
March 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28260207/biochemical-assessment-of-disease-control-in-acromegaly-reappraisal-of-the-glucose-suppression-test-in-somatostatin-analogue-sa-treated-patients
#8
Mai Christiansen Arlien-Søborg, Christian Trolle, Elin Alvarson, Amanda Bæk, Jakob Dal, Jens Otto Lunde Jørgensen
BACKGROUND: It is recommended not to measure growth hormone during oral glucose suppression (oral glucose tolerance test) during somatostatin analog treatment in acromegaly. However, we have observed that failure to suppress growth hormone in response to oral glucose tolerance test during somatostatin analog unmasks insufficient disease control and hypothesize that somatostatin analog also induces insufficient growth hormone suppression to mixed meals. METHODS: We therefore compared serum growth hormone levels during two mixed meals in patients with controlled insulin-like growth factor-I levels after either surgery alone (n = 9) or somatostatin analog treatment (n = 9)...
March 4, 2017: Endocrine
https://www.readbyqxmd.com/read/28255974/thyroid-lesions-in-patients-with-acromegaly-case-control-study-and-update-to-the-meta-analysis
#9
Kosma Woliński, Adam Stangierski, Edyta Gurgul, Barbara Bromińska, Agata Czarnywojtek, Martha Lodyga, Marek Ruchała
INTRODUCTION: Acromegaly results from oversecretion of growth hormone and subsequently insulin growth factor-1. According to some authors, the disease can cause increased prevalence of nodular goitre and thyroid cancer (TC). However, the number of studies comparing acromegalic patients with control groups is low. We aimed to assess the prevalence of thyroid lesions in patients with acromegaly in comparison to an age- and sex-matched control group and to update the meta-analysis previously performed in our department by the same authors...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28255899/acromegaly-a-pituitary-special-issue
#10
EDITORIAL
Maria Fleseriu, Monica Gadelha
No abstract text is available yet for this article.
February 2017: Pituitary
https://www.readbyqxmd.com/read/28250352/frequency-of-achilles-tendon-xanthoma-in-patients-with-acute-coronary-syndrome
#11
Taro Harada, Kyoko Inagaki-Tanimura, Mototsugu Nagao, Yuki Sato, Mariko Sudo, Fumitaka Okajima, Hitoshi Sugihara, Shinichi Oikawa
AIM: We studied the frequency of Achilles tendon xanthoma (ATX) in patients with acute coronary syndrome (ACS). Furthermore, we investigated the differences in clinical findings between ACS patients with and without ATX. METHODS: Patients with ACS (n=335) were admitted to the coronary care unit of Nippon Medical School between July 2011 and December 2014. Informed consent for the measurement of Achilles tendon thickness (ATT) on a radiograph was obtained from 228 patients without tendon rupture...
March 2, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28246150/changes-in-the-management-and-comorbidities-of-acromegaly-over-three-decades-the-french-acromegaly-registry
#12
Luigi Maione, Thierry Brue, Albert Beckers, Brigitte Delemer, Patrick Petrossians, Francoise Borson-Chazot, Olivier Chabre, Patrick Francois, Jerome Bertherat, Christine Cortet, Philippe Chanson
CONTEXT: Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN: The French registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and prospectively from 1999 until 2012. RESULTS: Data could be analyzed for 999 of the 1034 patients included in the registry (46% males)...
February 28, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28225314/the-prevalence-of-colonic-polyps-in-patients-with-acromegaly-a-case-control-nested-in-a-cohort-colonoscopic-study
#13
Baldomero Gonzalez, Guadalupe Vargas, Victoria Mendoza, Mariana Nava, Moisés Rojas, Moisés Mercado
BACKGROUND: Acromegaly is associated with an increased risk of colonic polyps. The magnitude of such risk is controversial and the characteristics that distinguish patients who develop polyps from those who do not are not well established. OBJECTIVE: To determine the prevalence of colonic polyps upon the diagnosis of acromegaly. To compare the clinical and biochemical features of patients with and without polyps Patients and methods: Out of 165 patients who underwent a full colonoscopy upon diagnosis of acromegaly, 53 were found to harbor colonic lesions (cases), whereas the remaining 112 conformed the group of controls...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28224726/a%C3%A4-rway-and-sleep-d%C3%A4-sorders-%C3%A4-n-pat%C3%A4-ents-w%C3%A4-th-acromegaly
#14
Onur Turan, Barış Akıncı, Ahmet Omer Ikız, Oya Itıl, Ibrahim Oztura, Emel Ada, Bahri Akdenız, Serkan Yener, Murat Kaya, Arzu Gedık, Abdurrahman Comlekcı
INTRODUCTION-OBJECTIVE: Acromegaly is a multisystemic disorder caused by excessive secretion of growth hormone (GH). Sleep-disordered breathing (SDB) such as sleep apnea syndrome (SAS) may occur in acromegaly. The aim of study was to assess the presence of sleep disorders and evaluate the systemic complications on respiratory, cardiovascular and upper airway systems in acromegalic patients. METHODS: The study group consisted of 30 acromegaly outpatients. GH and insulin-like growth factor 1 (IGF-1) measurements were obtained; body pletysmography, arterial blood gas analysis,tissue-doppler imaging,echocardiography,polysomnography,otorhinolaryngologic examination and head-neck computed tomography were performed...
February 22, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28224405/complications-of-acromegaly-cardiovascular-respiratory-and-metabolic-comorbidities
#15
REVIEW
Rosario Pivonello, Renata S Auriemma, Ludovica F S Grasso, Claudia Pivonello, Chiara Simeoli, Roberta Patalano, Mariano Galdiero, Annamaria Colao
Acromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction...
February 21, 2017: Pituitary
https://www.readbyqxmd.com/read/28220351/two-dimensional-speckle-tracking-echocardiography-demonstrates-no-effect-of-active-acromegaly-on-left-ventricular-strain
#16
I C M Volschan, L Kasuki, C M S Silva, M L Alcantara, R M Saraiva, S S Xavier, M R Gadelha
BACKGROUND: Speckle tracking echocardiography (STE) allows for the study of myocardial strain (ε), a marker of early and subclinical ventricular systolic dysfunction. Cardiac disease may be present in patients with acromegaly; however, STE has never been used to evaluate these patients. OBJECTIVE: To evaluate left ventricular (LV) global longitudinal strain in patients with active acromegaly with normal LV systolic function. DESIGN: Cross-sectional clinical study...
February 20, 2017: Pituitary
https://www.readbyqxmd.com/read/28217984/widening-of-joint-spaces-in-acromegaly
#17
Masei Suda, Yasuhiro Suyama, Masato Okada
No abstract text is available yet for this article.
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28217888/computed-tomography-airway-lumen-volumetry-in-patients-with-acromegaly-association-with-growth-hormone-levels-and-lung-function
#18
Gustavo Bittencourt Camilo, Alysson Roncally Silva Carvalho, Alan Ranieri Medeiros Guimarães, Leandro Kasuki, Mônica Roberto Gadelha, Roberto Mogami, Pedro Lopes de Melo, Agnaldo José Lopes
INTRODUCTION: The segmentation and skeletonisation of images via computed tomography (CT) airway lumen volumetry provide a new perspective regarding the incorporation of this technique in medical practice. Our aim was to quantify morphological changes in the large airways of patients with acromegaly through CT and, secondarily, to correlate these findings with hormone levels and pulmonary function testing (PFT) parameters. METHODS: This was a cross-sectional study in which 28 non-smoker patients with acromegaly and 15 control subjects underwent CT analysis of airway lumen volumetry with subsequent image segmentation and skeletonisation...
February 19, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28217565/therapeutic-use-of-hormones-on-tendinopathies-a-narrative-review
#19
REVIEW
Michele Abate, Matteo Guelfi, Andrea Pantalone, Daniele Vanni, Cosima Schiavone, Isabel Andia, Vincenzo Salini
BACKGROUND: Hormones can modify tendon homeostasis, some of them leading to tendon damage, while others are essentials for healing. This narrative review summarizes the current knowledge on the topic, focusing on the hormones normally secreted by endocrine glands. METHODS: A search in PubMed, Web of Knowledge and EMBASE, using the terms tendinopathy or tendon, combined with estrogens, testosterone, thyroid and parathyroid hormones, glucocorticoids and growth hormone, independently, was performed...
October 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28214144/ultrasound-and-radiographic-abnormalities-in-a-patient-with-chronic-severe-acromegaly
#20
Rita Fonseca, Alberto Fernández-Martínez, Roberto Miguélez, Jacqueline Uson
No abstract text is available yet for this article.
February 14, 2017: Reumatología Clinica
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