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Acromegaly

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https://www.readbyqxmd.com/read/28079576/mixed-gangliocytoma-pituitary-adenoma-insights-on-the-pathogenesis-of-a-rare-sellar-tumor
#1
M Beatriz S Lopes, Emily Sloan, Julie Polder
Gangliocytomas originating in the sellar region are rare; most are tumors composed of gangliocytic and pituitary adenomatous elements, forming the so-called mixed gangliocytoma-pituitary adenoma. The majority of mixed gangliocytoma adenomas are associated with endocrinopathies, mainly acromegaly and less often Cushing disease and hyperprolactinemia. In the present study, 10 cases of mixed gangliocytoma and somatotroph adenomas were evaluated for patterns of cellular differentiation and expression of lineage-specific transcription factors...
January 10, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28077497/bone-material-strength-index-as-measured-by-impact-microindentation-is-altered-in-patients-with-acromegaly
#2
Frank Malgo, Neveen Hamdy, Ton J Rabelink, H Kroon, Kim M J A Claessen, Alberto M Pereira, N R Biermasz, Natasha M Appelman-Dijkstra
OBJECTIVE: Acromegaly is a rare disease caused by excess growth hormone (GH) production by a pituitary adenoma. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of relatively normal Bone Mineral Density (BMD). We aimed to evaluate tissue-level properties of bone using impact microindentation (IMI) in well-controlled patients with acromegaly aged ≥18 years compared to 44 controls from the outpatient clinic of the Centre for Bone Quality...
January 11, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28060097/assessment-of-nasal-carriage-of-staphylococcus-aureus-and-axillar-flora-in-patients-with-acromegaly
#3
Ramazan Gen, Elif Şahin Horasan, Ümit Çinkir, Kerem Sezer, Esen Akbay
PURPOSE: Recent study showed that patients with acromegaly have typical skin findings including increased sebum secretion, decreased transepidermal water loss, more alkaline, and colder skin surface correlated with serum growth hormone and insulin-like growth factor 1 levels. Different anatomic localizations and texture of the skin differ in bacterial concentrations.Nasal carriage of Staphylococcus aureus and axillar flora in patients with acromegaly was compared with normal population with regard to duration of acromegaly as well as the growth hormone and insulin-like growth factor 1 levels...
January 5, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28042644/cardiovascular-comorbidities-in-acromegaly-an-update-on-their-diagnosis-and-management
#4
REVIEW
Ana M Ramos-Leví, Mónica Marazuela
Comorbidities related to the cardiovascular system are one of the most prevalent in patients with acromegaly, and contribute to an increased risk of morbidity and all-cause mortality. Specifically, hypertension, cardiomyopathy, heart valve disease, arrhythmias, atherosclerosis, coronary artery disease, and cardiac dysfunction may be frequent findings. Although the underlying physiopathology for each comorbidity may not be fully elucidated, uncontrolled growth hormone/insulin-like growth factor 1 excess, age, prolonged disease duration, and coexistence of other cardio-vascular risk factors are significant influencing variables...
January 2, 2017: Endocrine
https://www.readbyqxmd.com/read/28035526/auditory-changes-in-acromegaly
#5
S Tabur, H Korkmaz, E Baysal, E Hatipoglu, I Aytac, E Akarsu
OBJECTIVE: The aim of this study is to determine the changes involving auditory system in cases with acromegaly. MATERIALS AND METHODS: Otological examinations of 41 cases with acromegaly (uncontrolled n = 22, controlled n = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the control group did only have otological examination and PTA...
December 29, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28025719/cabergoline-in-acromegaly
#6
REVIEW
Emmanuelle Kuhn, Philippe Chanson
Acromegaly, a rare disease due to growth hormone (GH) hypersecretion by a pituitary adenoma, is associated with severe comorbidity and premature death if not adequately treated. The usual first-line treatment is surgery. Various drugs, including somatostatin receptor ligands, dopamine agonists and GH receptor antagonists, are now available for use if surgery fails to suppress GH/IGF-I hypersecretion. Cabergoline, now the preferred dopamine agonist for treating hyperprolactinemia, is also used off-label for treating acromegaly...
December 26, 2016: Pituitary
https://www.readbyqxmd.com/read/28025627/patients-with-acromegaly-presenting-with-colon-cancer-a-case-series
#7
Murray B Gordon, Samer Nakhle, William H Ludlam
Introduction. Frequent colonoscopy screenings are critical for early diagnosis of colon cancer in patients with acromegaly. Case Presentations. We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon cancer was identified in 2 patients (4.5%). Case  1 patient was a 36-year-old male with acromegaly who underwent transsphenoidal surgery to remove the pituitary adenoma. After surgery, the patient underwent routine colonoscopy screening, which revealed a 40 mm tubular adenoma in the descending colon...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28012070/remission-of-acromegaly-after-treatment-withdrawal-in-patients-controlled-by-cabergoline-alone-or-in-combination-with-octreotide-results-from-a-multicenter-study
#8
A Casagrande, M D Bronstein, R S Jallad, J I Mota, A Tabet, J Abucham
PURPOSE: Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. METHODS: To establish the remission rates (normal IGF-1 for age/sex: IGF-1 ≤ 1.00 xULN) after withdrawal of combined treatment with octreotide LAR and cabergoline and of cabergoline alone, we prospectively studied 16 patients with acromegaly controlled by those treatments in the preceding 2 years as part of a larger study on remission of acromegaly after withdrawal of different medical treatments...
December 23, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28008238/communication-practices-and-awareness-of-resources-for-acromegaly-patients-among-endocrinologists
#9
Susan Polanco-Briceno, Daniel Glass, Cindy Plunkett
PURPOSE: This study was designed to assess the awareness and utilization of resources to improve patients' treatment experiences among endocrinologists who currently treat patients with acromegaly. METHODS: A total of 4,280 US endocrinologists were randomly selected from the CMS National Plan and Provider Enumeration System and were invited by mail to participate in a 20-minute online survey. In order to qualify, respondents had to be the primary physician making treatment decisions for at least one patient for their acromegaly...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28002537/cerebral-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-in-acromegalic-patient-with-severe-headache
#10
LuminiŢa Nicoleta Cima, Simona Vasilica Fica, Alice Ioana Albu, Ioana Maria Lambrescu, Ioana SmărăndiŢa Lăcău, Bogdan Ovidiu Popescu, Mihaela Gherghiceanu, Corin Virgil Badiu, Carmen Gabriela Barbu
A 68-year-old female patient was admitted in our clinic with severe frontal bilateral headache, dizziness, depression and cognitive decline in the context of a previously diagnosed acromegaly. She also had high blood pressure, dyslipidemia, secondary diabetes mellitus. Acromegaly was caused by a growth hormone (GH) secreting-pituitary macroadenoma, so a transsphenoidal surgery was performed. The postoperative magnetic resonance imaging (MRI) scan revealed a 20÷22÷25 mm pituitary mass remnant and medical therapy with somatostatin analogues (SSAs) was started...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27998919/impact-of-aip-and-inhibitory-g-protein-alpha-2-proteins-on-clinical-features-of-sporadic-gh-secreting-pituitary-adenomas
#11
Elina Ritvonen, Esa Pitkänen, Atte Karppinen, Satu Vehkavaara, Hande Demir, Anders Paetau, Camilla Schalin-Jäntti, Auli Karhu
INTRODUCTION: In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumor features and reduced responsiveness to somatostatin analogues. AIP is a regulator of Gai signaling, but it is not known how the biological function of the Gai pathway is controlled. AIM: To study GNAS and AIP mutation status, AIP and Gai-2 protein expressions, Ki-67 proliferation indices and clinical parameters in patients having primary surgery because of acromegaly at a single center between years 2000 and 2010...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27998805/acromegaly-genetic-variants-of-the-aryl-hydrocarbon-receptor-pathway-and-environmental-burden
#12
S Cannavo, F Trimarchi, F Ferraù
Increasing evidence suggests that environmental contaminants can exert endocrine disruptors activities and that pollution exposition can have a role in tumorigenic processes. Several environmental pollutants have been shown to affect pituitary cells biology and function. The aryl hydrocarbon receptor (AHR) pathway is involved in xenobiotics' metabolism and in tumorigenesis. A deregulation of the AHR pathway could have a role in pituitary tumours' pathophysiology, especially in the GH secreting ones. AHR-interacting protein (AIP) is one of the key partners of AHR and is implicated in pituitary tumours' pathogenesis...
December 18, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27987061/management-of-aggressive-growth-hormone-secreting-pituitary-adenomas
#13
REVIEW
Daniel A Donoho, Namrata Bose, Gabriel Zada, John D Carmichael
Aggressive GH-secreting pituitary adenomas (GHPAs) represent an important clinical problem in patients with acromegaly. Surgical therapy, although often the mainstay of treatment for GHPAs, is less effective in aggressive GHPAs due to their invasive and destructive growth patterns, and their proclivity for infrasellar invasion. Medical therapies for GHPAs, including somatostatin analogues and GH receptor antagonists, are becoming increasingly important adjuncts to surgical intervention. Stereotactic radiosurgery serves as an important fallback therapy for tumors that cannot be cured with surgery and medications...
December 16, 2016: Pituitary
https://www.readbyqxmd.com/read/27982201/incidence-and-prevalence-of-clinically-relevant-pituitary-adenomas-retrospective-cohort-study-in-a-health-management-organization-in-buenos-aires-argentina
#14
Patricia Fainstein Day, Monica Graciela Loto, Mariela Glerean, María Fabiana Russo Picasso, Soledad Lovazzano, Diego Hernán Giunta
Objectives: The main purpose of this study was to estimate the incidence rate and prevalence of clinically relevant pituitary adenomas (PAs) within the Hospital Italiano Medical Care Program (HIMCP), a well-defined population of 150,000 members living in the urban and suburban area of the city of Buenos Aires. We defined clinically relevant PAs as those associated with endocrine dysfunction and/or mass effect. Subjects and methods: A retrospective open cohort study was conducted, including all members of the HIMCP over 18 years old, with active memberships during the period of the study, from January 1st 2003, to January 1, 2014...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27982199/elevated-igf-1-with-gh-suppression-after-an-oral-glucose-overload-incipient-acromegaly-or-false-positive-igf-1
#15
Pedro W Rosario, Maria R Calsolari
Objective: To report the evolution of patients with a suggestive clinical scenario and elevated serum insulin-like growth factor-1 (IGF-1), but growth hormone (GH) suppression in the oral glucose tolerance test (OGTT), in whom acromegaly was not initially excluded. Subjects and methods: Forty six patients with a suggestive clinical scenario, who had elevated IGF-1 (outside puberty and pregnancy) in two measurements, but GH < 0.4 µg/L in the OGTT, were selected...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27982196/diagnosis-of-acromegaly-black-white%C3%A2-and-sometimes-gray
#16
EDITORIAL
Philippe Chanson
No abstract text is available yet for this article.
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27974387/decrease-of-serum-igf-i-following-transsphenoidal-pituitary-surgery-for-acromegaly
#17
Min Yu, David E Bruns, John A Jane, Ralf M Nass, Edward H Oldfield, Mary Lee Vance, Michael O Thorner
BACKGROUND: In the immediate postoperative period following resection of growth hormone (GH)-secreting pituitary tumors, serum concentrations of GH have limited ability to predict remission of acromegaly. Since many actions of GH actions are mediated by insulin-like growth factor-1 (IGF-I), we aimed to determine the rates of fall of IGF-I during 72 h after surgical resection of pituitary tumors. METHODS: We studied patients who were undergoing pituitary surgery for acromegaly...
December 14, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27972240/real-world-comorbidities-treatment-pattern-and-cost-of-patients-with-acromegaly-in-poland-based-on-retrospective-analysis-of-administrative-claims-data
#18
A Sliwczynski, M Brzozowska, A Labenda, K Orlewska, M Milkowski, E Orlewska
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972170/cost-of-illness-of-acromegaly-in-sweden-a-register-linkage-population-based-study
#19
E Lesén, D Granfeldt, A Houchard, J Dinet, A Berthon, D S Olsson, I Björholt, G Johannsson
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972167/budget-impact-analysis-of-lanreotide-autogel-120-mg-in-the-treatment-of-acromegaly-in-poland
#20
E Orlewska, B Kos-Kudla, J Sowinski, K Sworczak, W Zgliczynski
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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