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Ulcerative colitis

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https://www.readbyqxmd.com/read/28343172/novel-immunoassays-for-detection-of-cuzd1-autoantibodies-in-serum-of-patients-with-inflammatory-bowel-diseases
#1
Sofia Farkona, Antoninus Soosaipillai, Panagiota Filippou, Christos Liaskos, Dimitrios P Bogdanos, Eleftherios P Diamandis, Ivan M Blasutig
BACKGROUND: Pancreatic autoantibodies (PABs) are detected in patients with inflammatory bowel disease (IBD). Their prevalence is higher in Crohn's disease (CrD) than in ulcerative colitis (UC). Glycoprotein 2 (GP2) and, more recently, CUB and zona pellucida-like domain-containing protein 1 (CUZD1) have been identified as target autoantigens of PAB. The clinical utility of CUZD1 autoantibodies has only recently been assessed by indirect immunofluorescence (IIF) assays. In this study, we developed and validated novel immunoassays for the detection of CUZD1 autoantibodies...
March 27, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28342949/use-of-thiopurines-during-conception-and-pregnancy-not-associated-with-adverse-pregancy-outcomes-or-health-of-infants-at-1-year-in-a-prospective-study
#2
Shannon L Kanis, Alison de Lima-Karagiannis, Nanne K H de Boer, C Janneke van der Woude
BACKGROUND & AIMS: Most data on the safety of thiopurine therapy for inflammatory bowel disease (IBD) during pregnancy come from retrospective studies, making it difficult to adjust for confounding factors. We performed a prospective cohort study to determine whether thiopurine use affects pregnancy outcomes or health outcomes of children. METHODS: We performed a prospective study of all women who visited the IBD preconception outpatient clinic at our tertiary health center in The Netherlands from December 2008 through May 2016...
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28338111/g-protein-coupled-receptor-30-gpr30-expression-pattern-in-inflammatory-bowel-disease-patients-suggests-its-key-role-in-the-inflammatory-process-a-preliminary-study
#3
Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Adam I Cygankiewicz, Damian Jacenik, Aleksandra Piechota-Polańczyk, Krystyna Stec-Michalska, Wanda M Krajewska, Jakub Fichna, Maria Wiśniewska-Jarosińska
BACKGROUND AND AIMS: G protein-coupled receptor 30 (GPR30) is a recently de-orphanized estrogen receptor that mediates the effects of estrogens on different cells. It has been postulated that in inflammatory bowel diseases (IBD) activation of GPR30 blocks the pathways dependent on pro-inflammatory cytokines. The aim of our study was to investigate GPR30 expression in patients with IBD and its potential implication in future therapies. METHODS: Fifty-seven patients were enrolled in our study: 20 subjects with Crohn's disease (CD), 22 with ulcerative colitis (UC) and 15 controls...
March 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28337881/indoleamine-2-3-dioxygenase-and-regulatory-t-cells-in-intestinal-mucosa-in-children-with-inflammatory-bowel-disease
#4
K Sznurkowska, A Żawrocki, J Sznurkowski, E Iżycka-Świeszewska, P Landowski, A Szlagatys-Sidorkiewicz, K Plata-Nazar, B Kamińska
Impaired immune regulation has been suggested as an underlying mechanism of inflammatory bowel disease. Indoleamine 2,3-dioxygenase (IDO) and regulatory T cells expressing FOXP3 are crucial elements of immune regulation. Conversion of FOXP3- lymphocytes to Tregs is one of the functions of IDO. The aim of this study was to evaluate the number of cells expressing FOXP3 and IDO in the lamina propria of intestinal mucosa and to evaluate correlations between these parameters and disease activity. Sixty-six children newly diagnosed with inflammatory bowel disease (41 patients with ulcerative colitis and 25 patients with Crohn’s disease) were included in the study...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337639/the-impact-of-mangiferin-from-belamcanda-chinensis-on-experimental-colitis-in-rats
#5
Marta Szandruk, Anna Merwid-Ląd, Adam Szeląg
BACKGROUND: Inflammatory bowel disease (IBD) [including Crohn's disease (CD) and ulcerative colitis (UC)] constitutes an important clinical problem. The pathogenesis of IBD remains unclear. It is believed that immune dysfunction, inflammatory mediators and oxidative damage play crucial roles in development of IBD. The condition is clinically associated with symptoms ranging from mild to severe during relapses, depending on the affected segment of the gastrointestinal tract. Bloody diarrhea with mucus, abdominal pain, weight loss and anemia are initial symptoms of both CD and UC...
March 24, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28337239/disease-activity-quality-of-life-and-indirect-costs-of-ulcerative-colitis-in-poland
#6
Paweł Kawalec, Ewa Stawowczyk, Małgorzata Mossakowska, Andrzej Pilc
INTRODUCTION: Ulcerative colitis (UC) require expensive, lifelong treatment, which generates huge direct costs and has a significant impact on the quality of life, especially in the active state of the disease. AIM: To assess the indirect costs, health-related quality of life, and clinical characteristics of patients with UC in Poland. Additionally, we investigated the association between activity of UC and productivity loss of patients in a Polish setting. MATERIAL AND METHODS: A questionnaire survey was conducted using the Patient Simple Clinical Colitis Activity Index (P-SCCAI) to assess disease activity, as well as the modified Work Productivity and Activity Impairment Questionnaire to assess productivity loss...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28337238/body-composition-as-an-indicator-of-the-nutritional-status-in-children-with-newly-diagnosed-ulcerative-colitis-and-crohn-s-disease-a-prospective-study
#7
Paweł Więch, Monika Binkowska-Bury, Bartosz Korczowski
INTRODUCTION: The prevalence of nutritional status disorders in children with ulcerative colitis (UC) is much lower than in the case of Crohn's disease (CD). The largest variability in the components of body composition occurs at the time of a new diagnosis and in periods of disease exacerbation. AIM: Assessment of body composition in children with UC and CD. MATERIAL AND METHODS: The preliminary study included 59 children with inflammatory bowel disease (IBD) (34 children with UC vs...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28337230/health-related-quality-of-life-assessment-among-patients-with-inflammatory-bowel-diseases-after-surgery-review
#8
REVIEW
Grażyna Bączyk, Dorota Formanowicz, Łukasz Gmerek, Piotr Krokowicz
Aim of the work was to review systematically the published literature addressing whether quality of life (QoL) and health-related QoL (HRQoL) are influenced by surgery among patients with inflammatory bowel disease (IBD). Electronic databases and published articles were searched to identify relevant studies published in the years 1990-2015. Then, a multistep selection was undertaken to identify articles that met specific selection criteria, such us specific key-words (IBD, HRQoL, ulcerative colitis (UC), Crohn's disease (CD), and surgery), and the population was assessed (studies concerning patients < 18 years old were excluded)...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28333769/the-incidence-of-low-seroimmunity-to-hepatitis-b-virus-in-children-with-inflammatory-bowel-disease
#9
Abhishek Watts, William E Bennett, Jean P Molleston, Sandeep K Gupta, Joseph M Croffie, Shamaila Waseem, Brian A McFerron, Steven J Steiner, Sanjay Kumar, Charles P Vanderpool, Emily C Hon, Molly A Bozic, Girish C Subbarao, Marian D Pfefferkorn
OBJECTIVES: Patients with inflammatory bowel disease (IBD) often receive immunosuppressive therapy which may make them vulnerable to infections such as hepatitis B. We hypothesized that hepatitis B virus (HBV) titers are low in the vaccinated pediatric IBD population. The aims of our study were to identify the incidence of lower titers of hepatitis B surface antibody (HBsAb) and determine which patient factors may be associated with lower HBsAb titers. METHODS: Patients with diagnosis of IBD, ages 5-18 years, were prospectively enrolled...
March 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28333362/budesonide-multi-matrix-is-efficacious-for-mesalamine-refractory-mild-to-moderate-ulcerative-colitis-a-randomized-placebo-controlled-trial
#10
David T Rubin, Russell D Cohen, William J Sandborn, Gary R Lichtenstein, Jeffrey Axler, Robert H Riddell, Cindy Zhu, Andrew C Barrett, Enoch Bortey, William P Forbes
Background and Aims.: Safety and efficacy of budesonide multimatrix, an oral extended-release second-generation corticosteroid designed for targeted delivery throughout the colon, was examined for induction of remission in patients with mild to moderate ulcerative colitis refractory to baseline mesalamine therapy. Methods.: A randomized, double-blind, placebo-controlled, multicenter trial evaluated efficacy and safety of budesonide multimatrix for induction of remission [ulcerative colitis disease activity index score ≥ 4 and ≤ 10] in 510 adults randomized to once-daily oral budesonide multimatrix 9 mg or placebo for 8 weeks...
March 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333358/cancer-risk-in-the-early-stages-of-inflammatory-bowel-disease-in-korean-patients-a-nationwide-population-based-study
#11
Yoon Suk Jung, Minkyung Han, Won Ho Kim, Sohee Park, Jae Hee Cheon
Background and Aims: The association between inflammatory bowel disease (IBD) and cancer remains poorly defined in Asian populations. Therefore, we conducted a nationwide population-based study to determine the cancer risk in Korean patients with IBD. Methods: Using the National Health Insurance claims data, we collected data on patients diagnosed with IBD (5,595 Crohn's disease [CD] and 10,049 ulcerative colitis [UC]) from 2011 to 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in IBD patients in comparison with the general population were calculated...
March 16, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333341/systemic-administration-of-sialorphin-attenuates-experimental-colitis-in-mice-via-interaction-with-mu-and-kappa-opioid-receptors
#12
M Salaga, A Mokrowiecka, D Jacenik, A I Cygankiewicz, E Malecka-Panas, R Kordek, W M Krajewska, M K Sobocinska, E Kamysz, J Fichna
Background and Aims: Pharmacological treatment and/or maintenance of remission in inflammatory bowel disease (IBD) is currently one of the biggest challenges in the field of gastroenterology. Here we aimed to assess the anti-inflammatory effect and the mechanism of action of sialorphin, the natural blocker of the endogenous opioid peptide-degrading enzymes neprilysin (NEP) and aminopeptidase N (APN), in the mouse models of IBD and the changes in the expression of these enzymes in IBD patients...
March 18, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333328/the-time-course-of-diagnostic-delay-in-inflammatory-bowel-disease-over-the-last-sixty-years-an-italian-multicentre-study
#13
Laura Cantoro, Antonio Di Sabatino, Claudio Papi, Giovanna Margagnoni, Sandro Ardizzone, Paolo Giuffrida, Diana Giannarelli, Alessandro Massari, Rita Monterubbianesi, Marco Vincenzo Lenti, Gino Roberto Corazza, Anna Kohn
Background and Aims: Inflammatory bowel disease (IBD) patients are still under-diagnosed or diagnosed with serious delay. We examined whether diagnostic delay (DD) in IBD has changed over the last 60 years, and explored the risk factors of longer DD. Methods: 3392 IBD patients recorded in the registry of four IBD Italian centres were divided according to the year of diagnosis into a historical cohort (HC: 1955-1984) and modern cohort (MC: 1985-2014). DD, i.e. time lapse between onset of symptoms indicative of IBD and definitive diagnosis, was divided into four sub-periods (0-6, 7-12, 13-24, >24 months) which were correlated with age and disease location/behaviour at diagnosis...
March 17, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333288/exposure-efficacy-relationships-for-vedolizumab-induction-therapy-in-patients-with-ulcerative-colitis-or-crohn-s-disease
#14
Maria Rosario, Jonathan L French, Nathanael L Dirks, Serap Sankoh, Asit Parikh, Huyuan Yang, Silvio Danese, Jean-Frédéric Colombel, Michael Smyth, William J Sandborn, Brian G Feagan, Walter Reinisch, Bruce E Sands, Miguel Sans, Irving Fox
Background and Aims: A positive relationship between vedolizumab trough serum concentrations and clinical outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) has been reported. Here we further explore exposure-efficacy relationships for vedolizumab induction therapy in post hoc analyses of GEMINI study data. Methods: Vedolizumab trough concentrations at Week 6 or 10 were grouped in quartiles and clinical outcome rates calculated. Exposure-efficacy relationships at Week 6 and potential baseline covariate effects were explored using logistic regression and individual predicted cumulative average concentration through Week 6 (Caverage) as exposure measure...
February 17, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333213/x-chromosome-wide-association-study-identifies-a-susceptibility-locus-for-inflammatory-bowel-disease-in-koreans
#15
Ho-Su Lee, Hyunjung Oh, Jiwon Baek, Seulgi Jung, Myunghee Hong, Kyung Mo Kim, Hyoung Doo Shin, Kyung-Jo Kim, Sang Hyoung Park, Byong Duk Ye, Buhm Han, Suk-Kyun Yang, Kyuyoung Song
Background and Aims: Genome-wide association studies of inflammatory bowel disease identified >200 susceptibility loci only in autosomes. This study aimed to identify inflammatory bowel disease susceptibility loci on the X chromosome. Methods: We performed an X chromosome-wide association study in Korean patients with inflammatory bowel disease. We analyzed X chromosome data from our recent genome-wide association studies, including 1,505 cases (922 Crohn's disease and 583 ulcerative colitis) and 4,041 controls during the discovery phase, followed by replication in additional 1,989 cases (993 Crohn's disease, 996 ulcerative colitis) and 3,491 controls...
February 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333209/assessment-of-endoscopic-mucosal-healing-of-ulcerative-colitis-using-linked-colour-imaging-a-novel-endoscopic-enhancement-system
#16
Kazuhiko Uchiyama, Tomohisa Takagi, Saori Kashiwagi, Yuki Toyokawa, Makoto Tanaka, Yuma Hotta, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Mitsuo Kishimoto, Nobuaki Yagi, Yuji Naito, Yoshito Itoh
Background and Aims: Mucosal healing and control of intestinal mucosal inflammation are important treatment goals for maintaining clinical remission in ulcerative colitis (UC) patients. Here, we investigated the efficacy of LCI, a novel endoscopic enhancement system, to diagnose mucosal inflammation in UC patients. Methods: All examinations were carried out with a LASEREO endoscopic system (FUJIFILM Co., Tokyo, Japan). Fifty-two patients with UC were enrolled, and 193 areas assessed by LCI were examined...
February 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333203/budesonide-mmx-add-on-to-5-aminosalicylic-acid-therapy-in-mild-to-moderate-ulcerative-colitis-a-favourable-risk-benefit-profile
#17
Silvio Danese, Stefanos Bonovas, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
February 21, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333202/risk-of-rectal-neoplasia-after-colectomy-and-ileorectal-anastomosis-for-ulcerative-colitis
#18
Mathieu Uzzan, Julien Kirchgesner, Nadia Oubaya, Aurélien Amiot, Jean-Marc Gornet, Philippe Seksik, Stéphane Nancey, Eddy Cotte, Matthieu Allez, Gilles Boschetti, David Laharie, Nicola de Angelis, Maria Nachury, Anne-Laure Pelletier, Vered Abitbol, Mathurin Fumery, Antoine Brouquet, Anthony Buisson, Romain Altwegg, Jacques Cosnes, Yves Panis, Xavier Treton
Introduction-: Colectomy can be required in the management of ulcerative colitis (UC). While ileal pouch anal-anastomosis (IPAA) is the recommended reconstruction technique, ileorectal anastomosis (IRA) is still performed and might present some advantages. However, the risk of rectal neoplasia might limit its indication. The aims of our study were to determine the incidence of rectal neoplasias following IRA for UC and to identify risk factors associated with rectal carcinomas. Methods-: We performed a multicenter retrospective study including patients who underwent IRA for UC from 1960 to 2014 in 13 centers...
February 21, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28332106/inadequate-gestational-weight-gain-predicts-adverse-pregnancy-outcomes-in-mothers-with-inflammatory-bowel-disease-results-from-a-prospective-us-pregnancy-cohort
#19
May-Bente Bengtson, Christopher F Martin, Geir Aamodt, Morten H Vatn, Uma Mahadevan
BACKGROUND: Malnutrition and weight loss are common features of patients with inflammatory bowel disease (IBD). AIM: To explore the impact of inadequate gestational weight gain (GWG) on adverse outcomes among IBD mothers in the prospective US pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes (PIANO) cohort. METHODS: The PIANO cohort comprises 559 and 363 pregnant mothers with Crohn's disease (CD) and ulcerative colitis (UC), respectively, enrolled between 2006 and 2014...
March 22, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28329471/first-report-of-mesalamine-5-aminosalicylic-acid-as-the-causative-agent-in-a-case-of-acute-generalized-exanthamous-pustulosis
#20
Erin Rocci, Kelly Park, Kelli Hutchens, Laura Winterfield
Acute generalized exanthamous pustulosis (AGEP)is a rare eruption of non-follicular sterile pustuleson a diffuse background of erythema and edema,commonly associated with fever and leukocytosis.Antibiotics are implicated in most cases; however,other drugs have been reported to cause AGEP. Wereport a case of a 73-year-old man with a historyof ulcerative colitis who presented with a diffusepustular rash, renal failure, elevated liver functiontests, and leukocytosis with neutrophilia. A week priorto admission, the patient was started on mesalamineto treat colitis...
January 15, 2017: Dermatology Online Journal
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