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JOURNAL ARTICLE
Stefan D Holubar, Douglas Nachand, Olga Lavryk, Mikhael Belkovsky, Rita Brienza, Nour Mohammed, Justin Ream, Tracy Hull, Scott R Steele, Miguel Regueiro, Benjamin L Cohen, Taha Qazi, Florian Rieder
BACKGROUND: Herein, we present a proof-of-concept study of 3-dimensional (3D) pouchography using virtual and printed 3D models of ileal pouch-anal anastomosis (IPAA) in patients with normal pouches and in cases of mechanical pouch complications. MATERIALS & METHODS: We performed a retrospective, descriptive case series of a convenience sample of 10 pouch patients with or without pouch dysfunction who had CT scans appropriate for segmentation were identified from our pouch registry...
April 22, 2024: Journal of Crohn's & Colitis
#2
JOURNAL ARTICLE
Jackson L Amaral, Naiara C Lucredi, Victor L B França, Samuel J M Santos, Francisco F Maia, Pablo A Morais, Pedro F N Souza, Jurandir F Comar, Valder N Freire
Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis, are associated with an uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. Their therapy is currently focused on the inhibition of cytokine receptors, such as the Janus kinase (JAK) protein family. Tofacitinib and peficitinib are JAK inhibitors that have been recently approved to treat rheumatoid arthritis. In this study, an in-depth analysis was carried out through quantum biochemistry to understand the interactions involved in the complexes formed by JAK1 and tofacitinib or peficitinib...
April 22, 2024: Physical Chemistry Chemical Physics: PCCP
#3
JOURNAL ARTICLE
Guannan Ye, Jiayi Zhang, Jin Peng, Zhen Zhou, Weining Wang, Si Yao
BACKGROUND AND AIM: Circular RNA (circRNA) has been found to mediate ulcerative colitis (UC) progression by regulating intestinal mucosal barrier function. However, the role of circSOD2 in UC process and its underlying molecular mechanism still need to be further elucidated. METHODS: Lipopolysaccharide (LPS)-induced Caco2 cells were used to mimic UC cell models. CircSOD2, miR-378g, and Snail1 levels were determined by quantitative real-time PCR. Cell viability was detected using MTT assay, and inflammatory cytokine levels were measured using ELISA...
April 22, 2024: Journal of Gastroenterology and Hepatology
#4
Nicole Ann E Villa, Dragos G Pausescu, Eduardo D Espiridion
Psychiatric polypharmacy involves the use of two or more psychotropic medications to manage a mental and emotional condition. The prevalence of psychotropic polypharmacy has been increasing since the 1990s and has been attributed to the rise in multiple psychiatric conditions presenting in one patient. However, as the prevalence of polypharmacy increases to maximize therapeutic advantages, so does the adverse effect profile of those drugs used in combination, leading to very life-threatening effects such as agranulocytosis...
March 2024: Curēus
#5
Yushi Oyama, Satoshi Koiwa, Takuya Maruyama, Ayako Kozuka, Seiichi Hiramori, Takahiro Kobayashi, Kumiko Yahikozawa, Takuya Miyagi, Takahiro Sakai, Kyuhachi Otagiri, Hiroshi Kitabayashi
UNLABELLED: Aortic mural thrombus (AMT) in the absence of aneurysm or atherosclerosis is a rare clinical finding and an uncommon cause of peripheral arterial embolization. AMT in a normal artery is usually attributed to systemic hypercoagulability. We describe a case of subacute lower limb ischemia due to AMT associated with active ulcerative colitis (UC). A 46-year-old man with active UC was referred to our hospital for the evaluation and treatment of left leg pain. Ultrasound and contrast computed tomography showed occlusion of the left popliteal artery, and an AMT in the abdominal aorta between the inferior mesenteric artery and the aortic bifurcation...
April 2024: Journal of Cardiology Cases
#6
Shun Okamura, Chie Bujo, Eisuke Amiya, Ken Kurokawa, Masaru Hatano, Junichi Ishida, Masaki Tsuji, Sozaburo Ihara, Keita Murakami, Chihiro Shiomi, Yoku Hayakawa, Mitsuhiro Fujishiro, Minoru Ono, Issei Komuro
UNLABELLED: Inflammatory bowel disease (IBD) is a complex chronic inflammatory intestinal disease. The development of de novo IBD after solid organ transplantation with immunosuppressive agents has been rarely reported. We present the case of a 65-year-old man with repeated colitis after heart transplantation (HTx) who was diagnosed with Crohn's disease (CD). The patient underwent HTx due to non-ischemic dilated cardiomyopathy. Six months after HTx, he developed serious diarrhea and a transient fever, which persisted for about 6 months...
April 2024: Journal of Cardiology Cases
#7
JOURNAL ARTICLE
Xiaoqi Liu, Hai Xiao, Mingxia Luo, Junpeng Meng, Lin Zhong, Tao Wu, Yongxia Zhao, Faming Wu, Jian Xie
Introduction: P. candolleana Wight et Arn. Is a traditional Chinese herbal medicine used by the Gelao nationality in southwest China, has been historically applied to treat various gastrointestinal disorders. Despite its traditional usage, scientific evidence elucidating its efficacy and mechanisms in treating ulcerative colitis (UC) remains sparse. This study aimed to determine the quality and chemical composition of Pimpinella candolleana and to identify its potential therapeutic targets and mechanisms in acetic acid-induced ulcerative colitis (UC) rats through integrated approaches...
2024: Frontiers in Pharmacology
#8
JOURNAL ARTICLE
Gihan F Asaad, Rasha E Mostafa
OBJECTIVES: Ulcerative colitis is a chronic inflammatory bowel disease (IBD) that causes inflammation and ulcers in the rectum and the innermost layer of the large intestine. Our study aimed to elucidate the ameliorative effect of cetirizine (CTZ) and loratadine (LOR) against acetic acid-induced ulcerative colitis in rats via assessment of the PI3K/p-Akt/Nrf2 signaling pathway and proinflammatory cytokine release. MATERIALS AND METHODS: Thirty-two rats were allocated into four groups (n=8)...
2024: Iranian Journal of Basic Medical Sciences
#9
JOURNAL ARTICLE
Xiuli Guo, DongPeng Wang, Yangxin Xiao, Huangliang Cao, Ding Yao, Gaoyuan Chen, Shuiqing Li, Guangzhong Wang, Jiyuan Tu, Yanju Liu
BACKGROUND: Appropriate conditions for storage of Artemisia argyi leaves reduce irritation during treatment and increase the active ingredient content. Naturally aged A. argyi leaves (≥1 year) are optimal for moxibustion; however, this process is time-consuming and costly. A comprehensive understanding of the conditions for artificial aging of A. argyi leaves and the mechanism of quality-marker conversion are required to guarantee A. argyi quality and moxibustion efficacy. OBJECTIVE: To identify the optimal conditions for artificial aging of A...
April 16, 2024: Phytomedicine
#10
EDITORIAL
Shinji Okabayashi, Taku Kobayashi
No abstract text is available yet for this article.
April 21, 2024: Alimentary Pharmacology & Therapeutics
#11
JOURNAL ARTICLE
Yasuharu Maeda, Shin-Ei Kudo, Giovanni Santacroce, Noriyuki Ogata, Masashi Misawa, Marietta Iacucci
This systematic review evaluated the current status of AI-assisted colonoscopy to identify histologic remission and predict the clinical outcomes of patients with ulcerative colitis. The use of artificial intelligence (AI) has increased substantially across several medical fields, including gastrointestinal endoscopy. Evidence suggests that it may be helpful to predict histologic remission and relapse, which would be beneficial because current histological diagnosis is limited by the inconvenience of obtaining biopsies and the high cost and time-intensiveness of pathological diagnosis...
April 19, 2024: Digestive and Liver Disease
#12
JOURNAL ARTICLE
Jun Yan He, Yang-Joon Kim, Elvira Mennillo, Iulia Rusu, Jared Bain, Arjun A Rao, Christopher Andersen, Karen Law, Hai Yang, Jessica Tsui, Alan Shen, Brittany Davidson, Divyashree Kushnoor, Yimin Shi, Frances Fan, Alexander Cheung, Li Zhang, Lawrence Fong, Alexis J Combes, Angela O Pisco, Michael G Kattah, David Y Oh
BACKGROUND: Colitis caused by checkpoint inhibitors (CPI) is frequent and is treated with empiric steroids, but CPI colitis mechanisms in steroid-experienced or refractory disease are unclear. METHODS: Using colon biopsies and blood from predominantly steroid-experienced CPI colitis patients, we performed multiplexed single-cell transcriptomics and proteomics to nominate contributing populations. RESULTS: CPI colitis biopsies showed enrichment of CD4+ resident memory (RM) T cells in addition to CD8+ RM and cytotoxic CD8+ T cells...
April 19, 2024: Journal for Immunotherapy of Cancer
#13
JOURNAL ARTICLE
Chen Wang, Qiao Chu, Wenxiao Dong, Xin Wang, Wenjing Zhao, Xin Dai, Wentian Liu, Bangmao Wang, Tianyu Liu, Weilong Zhong, Changtao Jiang, Hailong Cao
High-fat diet (HFD) has long been recognized as risk factors for the development and progression of ulcerative colitis (UC), but the exact mechanism remained elusive. Here, HFD increased intestinal deoxycholic acid (DCA) levels, and DCA further exacerbated colonic inflammation. Transcriptome analysis revealed that DCA triggered ferroptosis pathway in colitis mice. Mechanistically, DCA upregulated hypoxia-inducible factor-2α (HIF-2α) and divalent metal transporter-1 (DMT1) expression, causing the ferrous iron ions accumulation and ferroptosis in intestinal epithelial cells, which was reversed by ferroptosis inhibitor ferrostatin-1...
April 18, 2024: Molecular Metabolism
#14
JOURNAL ARTICLE
Ya-Na Yang, Bing Han, Mao-Qing Zhang, Na-Nan Chai, Feng-Lin Yu, Wen-Hui Qi, Meng-Yuan Tian, Dong-Zhi Sun, Ying Huang, Qing-Xin Song, Yan Li, Mao-Cui Zhu, Yuan Zhang, Xing Li
Ulcerative colitis (UC) is a severe hazard to human health. Since pathogenesis of UC is still unclear, current therapy for UC treatment is far from optimal. Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, possesses anti-microbial, anti-oxidant, anti-inflammatory, and anti-angiogenic properties. However, the potential effects of IXN on the alleviation of colitis and the action of the mechanism is rarely studied. Here, we found that administration of IXN (60 mg/kg/day, gavage) significantly attenuated dextran sodium sulfate (DSS)-induced colitis, evidenced by reduced DAI scores and histological improvements, as well as suppressed the pro-inflammatory Th17/Th1 cells but promoted the anti-inflammatory Treg cells...
April 20, 2024: Inflammopharmacology
#15
JOURNAL ARTICLE
Aakash Desai, Himsikhar Khataniar, Jana G Hashash, Francis A Farraye, Miguel Regueiro, Gursimran S Kochhar
BACKGROUND: Semaglutide, a glucagon-like peptide-1 receptor agonist, has shown sustained and clinically significant weight loss in the general population. There are limited data on outcomes of its use in patients with inflammatory bowel disease (IBD). METHODS: A retrospective cohort study was conducted between June 4, 2021, and December 11, 2023, using TriNetX, a U.S. multi-institutional database in patients with obesity who had IBD compared with patients without IBD...
April 20, 2024: Inflammatory Bowel Diseases
#16
JOURNAL ARTICLE
Pablo Canales-Herrerias, Mathieu Uzzan, Akihiro Seki, Rafael S Czepielewski, Bram Verstockt, Alexandra E Livanos, Fiona Raso, Alexandra Dunn, Daniel Dai, Andrew Wang, Zainab Al-Taie, Jerome Martin, Thomas Laurent, Huaibin M Ko, Minami Tokuyama, Michael Tankelevich, Hadar Meringer, Francesca Cossarini, Divya Jha, Azra Krek, John D Paulsen, Matthew D Taylor, Mohammad Zuber Nakadar, Joshua Wong, Emma C Erlich, Rachel L Mintz, Emily J Onufer, Beth A Helmink, Keshav Sharma, Adam Rosenstein, Danielle Ganjian, Grace Chung, Travis Dawson, Julius Juarez, Vijay Yajnik, Andrea Cerutti, Jeremiah J Faith, Mayte Suarez-Farinas, Carmen Argmann, Francesca Petralia, Gwendalyn J Randolph, Alexandros D Polydorides, Andrea Reboldi, Jean-Frederic Colombel, Saurabh Mehandru
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7+ ) plasmablasts in circulation of VDZ-treated patients suggested that VDZ targets gut-associated lymphoid tissue (GALT). Anti-α4β7 blockade in wild-type and photoconvertible (KikGR) mice confirmed a loss of GALT size and cellularity because of impaired cellular entry...
April 19, 2024: Science Immunology
#17
JOURNAL ARTICLE
Jian Liang, Weigang Dai, Chuanghui Liu, Yifan Wen, Chen Chen, Yifei Xu, Song Huang, Shaozhen Hou, Chun Li, Yongming Chen, Wei Wang, Hailin Tang
Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently to be developed. Gingerenone A (GA) is a phenolic compound known for its anti-inflammatory effect, but its effect on UC remains unknown. Here, it is shown that GA protects mice against UC, which is closely associated with inhibiting intestinal mucosal inflammation and enhancing intestinal barrier integrity in vivo and in vitro...
April 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#18
JOURNAL ARTICLE
Qian Zeng, Da Hu, Yuan Li, Zhiwei Zhou, Jinfeng Wu, Xiaodong Li, Xiqiu Yu
BACKGROUND AND OBJECTIVES: Previous observational studies have established a connection between bronchiectasis and inflammatory bowel disease (IBD), but none of these studies have provided a clear explanation for the underlying cause of this relationship. The present study thus implemented Mendelian randomization (MR) design to explore possible bidirectional relationships between IBD and bronchiectasis risk, with an additional focus on Crohn's disease (CD) and ulcerative colitis (UC) as IBD subtypes...
2024: Frontiers in Immunology
#19
REVIEW
Fei Hou, Xixi Bian, Dehuai Jing, Huikuan Gao, Fengqin Zhu
Adequate oxygen supply is essential for maintaining the body's normal physiological function. In chronic inflammatory conditions such as inflammatory bowel disease (IBD), insufficient oxygen reaching the intestine triggers the regulatory system in response to environmental changes. However, the pathogenesis of IBD is still under investigation. Recent research has highlighted the significant role of hypoxia in IBD, particularly the involvement of hypoxia-inducible factors (HIF) and their regulatory mechanisms, making them promising therapeutic targets for IBD...
2024: Gastroenterology Report
#20
Sareena Ali, Meghana Doniparthi, Nahren Asado, Kristina Borgen, Alan Shapiro
There is a known association between inflammatory bowel disease (IBD) and vasculitis, which can present with mesenteric ischemia or cutaneous manifestations. Infliximab, an anti-tumor necrosis factor (anti-TNF) used to treat IBD, has been implicated as a potential culprit. We present a unique case of a patient with ulcerative colitis who developed isolated celiac artery vasculitis presenting with abdominal pain and ileus after decreasing his dosage of azathioprine. Vasculitis resolved with steroids and increasing azathioprine dosage, while continuing anti-TNF therapy, suggesting that anti-TNF agents are not the only cause of vasculitis in patients with IBD or that thiopurines may be protective...
April 2024: ACG Case Reports Journal
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