keyword
MENU ▼
Read by QxMD icon Read
search

Diabetes type 2

keyword
https://www.readbyqxmd.com/read/28829997/msx2-is-required-for-vascular-smooth-muscle-cells-osteoblastic-differentiation-but-not-calcification-in-insulin-resistant-ob-ob-mice
#1
Maria Claudina Andrade, Luciana S Carmo, Elisangela Farias-Silva, Marcel Liberman
BACKGROUND AND AIMS: Obesity and diabetes potentiate vascular calcification by increasing vascular smooth muscle cells osteoblastic differentiation mediated by the transcription factor Msx2 and bone morphogenetic protein-2 signaling. However, Bmp-2/Msx2 crosstalk to induce VSMC osteogenic phenotype transition and calcification is poorly understood in diabetes. We aimed to investigate mechanisms underlying Bmp-2-driven VSMC osteogenic differentiation and calcification in leptin-deficient ob/ob mice...
July 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28829977/hdl-subclasses-and-the-common-cetp-taqib-variant-predict-the-incidence-of-microangiopatic-complications-in-type-2-diabetic-women-a-9years-follow-up-study
#2
Giuseppina T Russo, Annalisa Giandalia, Elisabetta L Romeo, Marco Muscianisi, Maria Concetta Ruffo, Angela Alibrandi, Alessandra Bitto, Fiorella Forte, Andrea Grillone, Bela Asztalos, Domenico Cucinotta
AIMS: Diabetic kidney disease (DKD) and retinopathy (DR) develop in a considerable number of subjects with Type 2 Diabetes (T2D) despite the achievement of the recommended targets for glycaemia and blood pressure. Atherogenic dyslipidemia may play a relevant role, especially in T2DM women. METHODS: We report our findings on the effect of diabetic dyslipidaemia, the HDL subclasses distribution and the common cholesteryl ester transfer protein (CETP)TaqIB variant on the incidence or the progression of DKD and DR in 97 T2D women, after a ∼9years of follow-up...
July 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28829491/the-effect-of-sitagliptin-on-obese-patients-with-insulin-treatment-induced-diabetes-mellitus
#3
S Li, H Li, R Wang, J-P Zhang
OBJECTIVE: The objective of the present study was to observe the effect of sitagliptin on obese patients with insulin treatment-induced diabetes mellitus. PATIENTS AND METHODS: A total of 120 obese patients with insulin treatment-induced diabetes mellitus were consecutively selected and divided into the control group (n=35), observation group 1 (n=40), and observation group 2 (n=45). The control group received different types or doses of insulin, observation group 1 received insulin combined with metformin, and observation group 2 received insulin combined with sitagliptin...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28829398/prevention-and-therapy-of-type-2-diabetes-what-is-the-potential-of-daily-water-intake-and-its-mineral-nutrients
#4
REVIEW
Johannes Naumann, Diana Biehler, Tania Lüty, Catharina Sadaghiani
We aim to present an overview of the possible influence of drinking water in general and mineral water in particular in improving glycemic parameters in persons with or without type 2 diabetes. We performed a literature search that produced 15 randomized controlled trials (RCTs) on this topic with mainly small sample sizes. We also discuss relevant observational and animal studies as well as the effects of important supplements in mineral water such as hydrogencarbonate and magnesium. There is low evidence for the positive effects of water or mineral water in improving glycemic parameters in diabetic and non-diabetic persons, and the results are heterogenous, making it difficult to reach an unequivocal conclusion...
August 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28829397/precision-nutrition-a-review-of-personalized-nutritional-approaches-for-the-prevention-and-management-of-metabolic-syndrome
#5
REVIEW
Juan de Toro-Martín, Benoit J Arsenault, Jean-Pierre Després, Marie-Claude Vohl
The translation of the growing increase of findings emerging from basic nutritional science into meaningful and clinically relevant dietary advices represents nowadays one of the main challenges of clinical nutrition. From nutrigenomics to deep phenotyping, many factors need to be taken into account in designing personalized and unbiased nutritional solutions for individuals or population sub-groups. Likewise, a concerted effort among basic, clinical scientists and health professionals will be needed to establish a comprehensive framework allowing the implementation of these new findings at the population level...
August 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28829354/long-noncoding-rnas-as-diagnostic-and-therapeutic-targets-in-type-2-diabetes-and-related-complications
#6
REVIEW
Fatjon Leti, Johanna K DiStefano
Protein-coding genes represent only a small fraction of the human genome. In the past, the majority of the genomic sequence has been considered transcriptionally silent, but recent large-scale studies have uncovered an array of functionally significant elements, including non-protein-coding transcripts, within these noncoding regions of the human genome. Long noncoding RNAs (lncRNAs), a class of noncoding transcripts with lengths >200 nucleotides, are pervasively transcribed in the genome and function as signals, decoys, guides, or scaffolds to regulate gene expression...
August 22, 2017: Genes
https://www.readbyqxmd.com/read/28829328/promoting-engagement-with-a-digital-health-intervention-help-diabetes-using-email-and-text-message-prompts-mixed-methods-study
#7
Ghadah Alkhaldi, Kerstin Modrow, Fiona Hamilton, Kingshuk Pal, Jamie Ross, Elizabeth Murray
BACKGROUND: Engagement with digital health interventions (DHIs) may be regarded as a prerequisite for the intervention to achieve positive health or behavior change outcomes. One method employed to promote engagement is the use of prompts such as emails and text messages. However, little is known about the characteristics of prompts that promote engagement. This study explored the association between the content and delivery mode of prompts and the users' engagement with HeLP-Diabetes (Healthy Living for People with type 2 Diabetes), a DHI that aimed to promote self-management in adults with type 2 diabetes...
August 22, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28829247/distinct-predictors-and-comorbidities-in-early-onset-type-2-diabetes-mellitus-among-asian-indians
#8
Gadadharan Vijayakumar, Ganapathy K Sreehari, Aswathi Vijayakumar, Abdul Jaleel
BACKGROUND: The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide, and the age of disease onset is falling. Although there is rising prevalence of early onset T2DM in India, little is known about their clinical characteristics and cardiovascular risks profiles. The aim of this study was to address this knowledge gap by comparing the characteristics of early onset T2DM and usual onset T2DM patients from our clinic population in India. METHODS: We studied the clinical and biochemical parameters of 98 consecutive early onset T2DM patients of age <45 and <5 years of disease duration and compared those parameters with 86 consecutive usual onset T2DM patients of age >50 years and similar disease duration...
August 22, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28829213/safety-evaluation-of-trelagliptin-in-the-treatment-of-japanese-type-2-diabetes-mellitus-patients
#9
Kohei Kaku
Trelagliptin is a novel, long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM) in Japan. The safety and efficacy of trelagliptin has been evaluated in three published clinical trials to date: one phase 2 and two phase 3 studies. As trelagliptin only requires dosing once per week, this new agent has the potential to improve compliance and subsequently, glycaemic control, in patients with T2DM. Areas covered: This article reviews the available safety data for trelagliptin from published clinical trials, and evaluates the published safety profile relative to competitor once-daily and once-weekly DPP-4 inhibitors...
August 22, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28829163/effect-of-dapagliflozin-on-glycemic-control-weight-and-blood-pressure-in-patients-with-type-2-diabetes-attending-a-specialist-endocrinology-practice-in-canada-a-retrospective-cohort-analysis
#10
Ruth E Brown, Nikhil Gupta, Ronnie Aronson
BACKGROUND: In randomized clinical trials, dapagliflozin has been shown to improve glycemic control, weight, and blood pressure. However, there is little real-world evidence of the effectiveness of dapagliflozin. The objective of this study is to investigate the real-world treatment outcomes of patients with type 2 diabetes (T2D) who initiated dapagliflozin in a referral-based endocrinology practice. METHODS: This study was a retrospective cohort analysis of patients with T2D who initiated dapagliflozin in 2015, using data from a large, specialist diabetes registry in Canada...
August 22, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28829122/olive-component-oleuropein-promotes-%C3%AE-cell-insulin-secretion-and-protects-%C3%AE-cells-from-amylin-amyloid-induced-cytotoxicity
#11
Ling Wu, Paul Velander, Dongmin Liu, Bin Xu
Oleuropein, a natural product derived from olive leaves, has reported anti-diabetic functions. However, detailed molecular mechanisms on how it affects β-cell functions remain poorly understood. Here, we present evidence that oleuropein promotes glucose-stimulated insulin secretion (GSIS) in β-cells. The effect is dose-dependent and it stimulates ERK/MAPK signaling pathway. We further demonstrated that oleuropein inhibits the cytotoxicity induced by amylin amyloid, a hallmark feature of type 2 diabetes. We demonstrated that these dual functions are structural-specific: we identified 3-hydroxytyrosol moiety of oleuropein as the main functional entity for amyloid inhibition, but the novel GSIS function requires the entire structure scaffold of the molecule...
August 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28828979/chronic-latent-magnesium-deficiency-in-obesity-decreases-positive-effects-of-vitamin-d-on-cardiometabolic-risk-indicators
#12
Edita Stokic, Andrea Romani, Branislava Ilincic, Aleksandar Kupusinac, Zoran Stosic, Esma R Isenovic
BACKGROUND: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and cardiovascular disease (CVD). OBJECTIVE: We examined the frequency of concomitant deficit of magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. METHOD: Non-diabetic middle aged adults (n = 80; mean age 36 ± 4 years, 52% women) were recruited based on weight/adiposity parameters [i...
August 21, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28828937/development-and-psychometric-testing-of-the-diabetes-caregiver-activity-and-support-scale
#13
Lisa J Scarton, Tamilyn Bakas, Wendy R Miller, Susan M McLennon, Lesa L Huber, Margie A Hull
Purpose The purpose of this study was to develop and psychometrically test the Diabetes Caregiver Activity and Support Scale (D-CASS), a measure of how difficult or easy caregiver activity and supportive behaviors are for family caregivers of persons with type 2 diabetes (T2DM). Methods Internal consistency reliability, test-retest reliability, criterion-related validity, and construct validity were examined in 101 family caregivers of persons with T2DM. Participants were recruited using study brochures distributed at a large hospital in the Midwest and at statewide American Indian Pow Wows...
August 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28828933/impact-of-timely-treatment-intensification-on-glycemic-goal-achievement-in-patients-with-type-2-diabetes-failing-metformin-monotherapy
#14
Rohan Mahabaleshwarkar, Megan Templin, Frank Gohs, Holly Mulder, Andrea DeSantis, Flavia Ejzykowicz, Swapnil Rajpathak, Nick Wilkins
Purpose The purpose of the study was to examine the association between timely treatment intensification (TTI) and glycemic goal achievement in patients with type 2 diabetes (T2D) failing metformin monotherapy (MM). Methods This study was set at a large integrated health care system in the United States. The study cohort included T2D patients aged 18 to 85 years who were on MM between January 2009 and September 2013 and had an uncontrolled glycated hemoglobin (A1C) reading (≥8%) after at least 3 months of MM (corresponding date was index date)...
August 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28828879/social-support-and-coping-in-adults-with-type-2-diabetes
#15
Samantha Ramkisson, Basil J Pillay, Wilbert Sibanda
BACKGROUND: The diagnosis of diabetes has been described as a lifelong psychological burden on the patient and his or her family. Social support plays a pivotal role in patients with diabetes and is important in enabling them to cope effectively with the disease. There is a dearth of research on social support and coping in patients with diabetes in South Africa. OBJECTIVES: The aim of this study was to explore whether patients with poor perceived social support have lower levels of well-being and coping than patients with good social support...
July 31, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28828521/recombinant-lactococcus-lactis-expressing-bioactive-exendin-4-to-promote-insulin-secretion-and-beta-cell-proliferation-in-vitro
#16
Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang, Huiqin Ma, Shangwu Chen
In recent years, therapeutic peptides have garnered great interest in the pharmaceutical industry for the treatment of diabetes. Lactic acid bacteria (LAB) are an appealing vehicle for safe and convenient oral delivery of bioactive peptide and protein drugs. Exendin-4 (Exd4) is a glucagon-like protein-1 (GLP-1) receptor agonist that is considered an excellent therapeutic peptide drug for type 2 diabetes due to its longer-lasting bioactivity, resulting from resistance to dipeptidyl peptidase 4. We explored Lactococcus lactis with the nisin-controlled gene expression (NICE) system as an oral delivery system for recombinant (r) Exd4 peptide in situ...
August 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28828490/continuous-glucose-monitoring-in-patients-with-type-2-diabetes-receiving-insulin-injections-does-this-mean-continuous-glucose-monitoring-for-everyone
#17
Vanessa Arguello, Matthew Freeby
No abstract text is available yet for this article.
August 22, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28828488/continuous-glucose-monitoring-in-patients-with-type-2-diabetes
#18
(no author information available yet)
No abstract text is available yet for this article.
August 22, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28828487/continuous-glucose-monitoring-versus-usual-care-in-patients-with-type-2-diabetes-receiving-multiple-daily-insulin-injections-a-randomized-trial
#19
Roy W Beck, Tonya D Riddlesworth, Katrina Ruedy, Andrew Ahmann, Stacie Haller, Davida Kruger, Janet B McGill, William Polonsky, David Price, Stephen Aronoff, Ronnie Aronson, Elena Toschi, Craig Kollman, Richard Bergenstal
Background: Continuous glucose monitoring (CGM), which studies have shown is beneficial for adults with type 1 diabetes, has not been well-evaluated in those with type 2 diabetes receiving insulin. Objective: To determine the effectiveness of CGM in adults with type 2 diabetes receiving multiple daily injections of insulin. Design: Randomized clinical trial. (The protocol also included a type 1 diabetes cohort in a parallel trial and subsequent second trial...
August 22, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28828484/presence-of-peripheral-neuropathy-is-associated-with-progressive-thinning-of-retinal-nerve-fiber-layer-in-type-1-diabetes
#20
Cirous Dehghani, Sangeetha Srinivasan, Katie Edwards, Nicola Pritchard, Anthony W Russell, Rayaz A Malik, Nathan Efron
Purpose: Reduced retinal nerve fiber layer (RNFL) thickness has been demonstrated in patients with diabetic peripheral neuropathy (DPN) in cross-sectional studies. This prospective study defines longitudinal alterations to the RNFL thickness in individuals with type 1 diabetes without (DPN-ve) and with (DPN+ve) DPN and in relation to risk factors for nerve damage. Methods: A cohort of 105 individuals with type 1 diabetes (20% DPN+ve) with predominantly mild or no retinopathy and no previous retinal photocoagulation underwent spectral-domain optical coherence tomography (SD-OCT) at baseline, 2 years, and 4 years...
May 1, 2017: Investigative Ophthalmology & Visual Science
keyword
keyword
12762
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"