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Diabetes type 2

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https://www.readbyqxmd.com/read/29684904/excess-hospitalization-expenses-attributable-to-type-2-diabetes-mellitus-in-singapore
#1
May Ee Png, Joanne Yoong, Chuen Seng Tan, Kee Seng Chia
OBJECTIVES: To estimate the excess hospitalization expenses attributable to type 2 diabetes mellitus (T2DM) in a high-income Asian country from the health system perspective and the patient perspective. METHODS: Electronic medical records from a tertiary academic hospital in Singapore from 2012 to 2013 were used to create propensity score-matched cohorts with and without T2DM on the basis of their entry characteristics. A two-part model was then used to control for remaining differences between the cohorts...
April 20, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29684848/protective-effects-of-ifn-%C3%AE-on-the-kidney-of-type-2-diabetic-kkay-mice
#2
Juan Du, Wenpeng Dong, Huifeng Li, Bo Li, Xiaodan Liu, Qinghui Kong, Wei Sun, Tingli Sun, Peilong Ma, Yan Cui, Ping Kang
BACKGROUND: Development of novel therapeutic strategies that specifically target diabetic kidney disease (DKD) is urgently needed. METHODS: Male KKAy mice were divided randomly into three equal groups - KK, KI, and KF; Male C57BL/6 mice were the control group. All KKAy mice were fed a high-fat diet. From the 16th week, the KI group was given IFN-γ, and the KF group was assigned to be treated with fludarabine. C57BL/6 mice were always fed a normal mouse diet. Every 4 weeks, body weight, random blood sugar, urine albumin and urea of all mice were measured...
December 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29684667/demographics-and-socioeconomic-status-as-predictors-of-weight-loss-after-laparoscopic-sleeve-gastrectomy-a-prospective-cohort-study
#3
Amani Jambhekar, Amy Maselli, Shawn Robinson, Krystyna Kabata, Piotr Gorecki
BACKGROUND: Prior studies have established that race and socioeconomic factors may influence weight loss after bariatric surgery. Few studies have focused on laparoscopic sleeve gastrectomy (LSG). The objective of this study is to determine if demographic factors may predict postoperative weight loss following LSG. METHODS: Prospectively collected data on 713 consecutive primary LSG operations performed with the same technique between February 2010 and May 2016 by a single surgeon (PG) were analyzed...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684619/preventing-type-2-diabetes-and-cardiovascular-disease-in-women-with-gestational-diabetes-the-evidence-and-potential-strategies
#4
REVIEW
Graziano Di Cianni, Emilia Lacaria, Cristina Lencioni, Veronica Resi
Gestational Diabetes Mellitus is a condition strongly related to the development of type 2 diabetes later in life, although the risk and the onset have not been fully identified yet. Although glucose tolerance returns to normal levels after delivery in the majority of women with GDM, this condition represents an early stage in the natural history of T2DM. In addition, women with previous GDM exhibit an increased cardiovascular risk profile and a raised incidence of cardiovascular diseases. Lifestyle changes and pharmacological interventions might be able to reduce the incidence of type 2 diabetes in pGDM women, although results are still not conclusive...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29684616/serum-fibrinogen-predicts-diabetic-esrd-in-patients-with-type-2-diabetes-mellitus
#5
Junlin Zhang, Yiting Wang, Rui Zhang, Hanyu Li, Qianqian Han, Yucheng Wu, Shanshan Wang, Ruikun Guo, Tingli Wang, Li Li, Fang Liu
AIMS: Although increased serum fibrinogen level was often observed in patients with diabetic nephropathy (DN), its association with DN severity and progression remains unclear. The aim of this study was to investigate the relationship between the serum fibrinogen levels and clinicopathological features and renal prognosis in Chinese patients with type 2 diabetes mellitus (T2DM) and DN. METHODS: A total of 174 patients with T2DM and biopsy-proven DN were enrolled...
April 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29684558/effects-of-exercise-on-brown-and-beige-adipocytes
#6
REVIEW
Revati S Dewal, Kristin I Stanford
Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise. Studies investigating the effects of exercise on BAT have produced conflicting results, with some showing an increase in the thermogenic activity of BAT and some demonstrating a decrease in the thermogenic activity of BAT...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684544/the-international-childhood-cardiovascular-cohort-i3c-consortium-outcomes-study-of-childhood-cardiovascular-risk-factors-and-adult-cardiovascular-morbidity-and-mortality-design-and-recruitment
#7
Alan R Sinaiko, David R Jacobs, Jessica G Woo, Lydia Bazzano, Trudy Burns, Tian Hu, Markus Juonala, Ronald Prineas, Olli Raitakari, Julia Steinberger, Elaine Urbina, Alison Venn, Cashell Jaquish, Terry Dwyer
Although it is widely thought that childhood levels of cardiovascular (CV) risk factors are related to adult CV disease, longitudinal data directly linking the two are lacking. This paper describes the design and organization of the International Childhood Cardiovascular Cohort Consortium Outcomes Study (i3C Outcomes), the first longitudinal cohort study designed to locate adults with detailed, repeated, childhood biological, physical, and socioeconomic measurements and a harmonized database. I3C Outcomes uses a Heart Health Survey (HHS) to obtain information on adult CV endpoints, using mail, email, telephone, and clinic visits in the United States (U...
April 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29684505/protective-effects-of-sulforaphane-on-cognitive-impairments-and-ad-like-lesions-in-diabetic-mice-are-associated-with-the-upregulation-of-nrf2-transcription-activity
#8
Die Pu, Yuxing Zhao, Jinliang Chen, Yue Sun, Ankang Lv, Shiyu Zhu, Cheng Luo, Kexiang Zhao, Qian Xiao
Type 2 diabetes mellitus (T2DM)-associated oxidative stress contributes to cognitive deficiencies and Alzheimer's disease (AD). Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions. This study investigated the effects of SFN on DM-related cognitive decline and its potential mechanisms. Morris water maze (MWM) tests showed that SFN (1 mg/kg i.p. for 28 days) mitigated the cognitive decline of db/db mice, a transgenic mouse model of T2DM...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29684344/er-stress-attenuation-by-aloe-derived-polysaccharides-in-the-protection-of-pancreatic-%C3%AE-cells-from-free-fatty-acid-induced-lipotoxicity
#9
K S Kim, M H Chung, S Y Park, J M Cha, J H Baek, S Y Lee, S-Y Choi
Insulin resistance, a pathophysiology of type 2 diabetes, is associated with obesity. Lipotoxicity in obesity leads to the dysfunction and death of pancreatic β-cells and inadequate insulin production, thereby aggravating type 2 diabetes. The present study was conducted to determine the effect of Aloe vera polysaccharides (APs) as an anti-hyperglycemic agent and their mechanisms of action. Gel polysaccharides from Aloe extracts were separated using ultrafiltration devices with molecular weight-cutoff membranes, and the protective effect of APs on pancreatic β-cells in response to free fatty acids (FFAs) was determined...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29684298/the-efficacy-of-selected-bariatric-surgery-methods-on-lipid-and-glucose-metabolism-a-retrospective-12-month-study
#10
Marek Bužga, Petra Marešová, Karin Petřeková, Pavol Holéczy, Kamil Kuča
OBJECTIVE: Approximately 25% of the Czech population is currently obese. Obesity rates are expected to increase in the future. Obesity not only raises the risk of health complications for individuals, but increasing rates also represent a significant and steadily growing economic burden for healthcare systems and society as a whole. The aim of this study was to evaluate the therapeutic efficacy of three methods of bariatric surgery: laparoscopic greater curve plication (LGCP), laparoscopic sleeve gastrectomy (LSG), and Roux-en-Y gastric bypass (RYBG) in patients with type 2 diabetes mellitus (DM)...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684218/what-is-the-evidence-for-a-role-for-diet-and-nutrition-in-osteoarthritis
#11
Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman
As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29684121/incidence-and-prevalence-of-diabetes-and-cost-of-illness-analysis-of-polycystic-ovary-syndrome-a-bayesian-modelling-study
#12
Tao Ding, Paul J Hardiman, Irene Petersen, Gianluca Baio
STUDY QUESTION: What is the incidence/prevalence of type 2 diabetes in women with polycystic ovary syndrome (PCOS) and the economic burden associated with PCOS in the UK? SUMMARY ANSWER: The incidence and prevalence of type 2 diabetes in women with PCOS are 3-33 per 1000 person years and 26.5%, respectively, with an associated annual healthcare burden of at least £237 million in the UK. WHAT IS KNOWN ALREADY: Although observational studies have been designed to assess the incidence of diabetes in women with PCOS, these have been open to criticism because of short periods of follow-up, small sample sizes or invalidated diagnosis of PCOS...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684031/computationally-identified-novel-agonists-for-gprc6a
#13
Min Pi, Karan Kapoor, Ruisong Ye, Dong-Jin Hwang, Duane D Miller, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
New insights into G protein coupled receptor regulation of glucose metabolism by β-cells, skeletal muscle and liver hepatocytes identify GPRC6A as a potential therapeutic target for treating type 2 diabetes mellitus (T2D). Activating GPRC6A with a small molecule drug represents a potential paradigm-shifting opportunity to make significant strides in regulating glucose homeostasis by simultaneously correcting multiple metabolic derangements that underlie T2D, including abnormalities in β-cell proliferation and insulin secretion and peripheral insulin resistance...
2018: PloS One
https://www.readbyqxmd.com/read/29683909/acog-committee-opinion-no-734-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#14
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683904/acog-committee-opinion-no-734-summary-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#15
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#16
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29683271/piperine-promotes-glucose-uptake-through-ros-dependent-activation-of-the-camkk-ampk-signaling-pathway-in-skeletal-muscle
#17
Ayumi Maeda, Takeshi Shirao, Daishi Shirasaya, Yasukiyo Yoshioka, Yoko Yamashita, Mitsugu Akagawa, Hitoshi Ashida
SCOPE: The prevalence of type 2 diabetes mellitus (T2DM) is increasing yearly worldwide. Glycemic control is the basis for the treatment of T2DM, as it can prevent the progress of associated complications. Spices possess various health beneficial effects on humans. The aim of this study was to search for spices that can promote glucose uptake and to elucidate the underlying molecular mechanism(s). METHODS AND RESULTS: Among 24 spice extracts, the extracts from black and white pepper significantly increased glucose uptake in L6 myotubes...
April 23, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29683147/corrigendum-to-urinary-exosomal-microrna-profiling-in-incipient-type-2-diabetic-kidney-disease
#18
Yijun Xie, Yijie Jia, Cuihua Xie, Fang Hu, Meng Xue, Yaoming Xue
[This corrects the article DOI: 10.1155/2017/6978984.].
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29683100/pioglitazone-therapy-and-fractures-systematic-review-and-meta-analysis
#19
Velichka Pavlova, Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
INTRODUCTION: Thiazolidinediones are group of synthetic medications used in type 2 diabetes treatment. Among available thiazolidinediones pioglitazone is gaining increased attention due to its lower cardiovascular risk in type 2 diabetes mellitus sufferers and seems a promising future therapy. Accumulating evidence suggests that diabetic patients may exert bone fractures due to such treatments. Simultaneously, female population is thought to be at greater risk. Still the safety outcomes of pioglitazone treatment especially in terms of fractures are questionable and need to be clarified...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29683094/role-of-inflammatory-markers-in-elderly-type-2-diabetic-patients-with-mild-cognitive-impairment
#20
Salwa S Hosny, Ahmed M Bahaaeldin, Mohamed S Khater, Meram M Bekhet, Hayam A Hebah, Ghada A Hasanin
BACKGROUND: Type 2 diabetes (T2DM) is a risk factor for Alzheimer's disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. OBJECTIVES: to determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI)...
April 22, 2018: Current Diabetes Reviews
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