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https://www.readbyqxmd.com/read/29228513/an-analysis-of-the-morbidity-and-mortality-of-diabetes-mellitus-in-a-forensic-context
#1
Chong Zhou, Roger W Byard
To investigate the spectrum of diseases seen in diabetes mellitus in a forensic context, all autopsy reports of diabetic individuals who presented to Forensic Science, South Australia (FSSA), over a 5-year period from 2005 to 2009 were studied. The leading cause of death was cardiovascular disease (55.0%), followed by unnatural deaths (15.4%) and infections (9.4%). In type 1 diabetics, principal causes of death included cardiovascular disease (44.7%), acute metabolic complications (18.7%), unnatural deaths (17...
December 11, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29228501/hcv-clearance-by-direct-acting-antiviral-treatments-reverses-insulin-resistance-in-chronic-hepatitis-c-patients
#2
Luigi E Adinolfi, Riccardo Nevola, Barbara Guerrera, Giovanni D'Alterio, Aldo Marrone, Mauro Giordano, Luca Rinaldi
BACKGROUND AND AIM: Chronic hepatitis C (HCV), particularly genotype 1, is associated with insulin resistance (IR) and diabetes. We evaluated the impact of HCV clearance by all-oral direct-acting antiviral (DAAs) treatments on IR and glycemic control. METHODS: Included in this prospective case-control study were 133 consecutive HCV-genotype 1 patients with advance liver fibrosis (F3-F4) without type 2 diabetes. Sixty-eight treated with DAAs and 65 untreated. Liver fibrosis was assessed by transient elastography...
December 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29228058/altered-intragenic-dna-methylation-of-hook2-gene-in-adipose-tissue-from-individuals-with-obesity-and-type-2-diabetes
#3
Sandra Rodríguez-Rodero, Edelmiro Menéndez-Torre, Gustavo Fernández-Bayón, Paula Morales-Sánchez, Lourdes Sanz, Estrella Turienzo, Juan José González, Ceferino Martinez-Faedo, Lorena Suarez-Gutiérrez, Jessica Ares, Lucia Díaz-Naya, Alicia Martin-Nieto, Juan L Fernández-Morera, Mario F Fraga, Elías Delgado-Álvarez
AIMS/HYPOTHESIS: Failure in glucose response to insulin is a common pathology associated with obesity. In this study, we analyzed the genome wide DNA methylation profile of visceral adipose tissue (VAT) samples in a population of individuals with obesity and assessed whether differential methylation profiles are associated with the presence of type 2 diabetes (T2D). METHODS: More than 485,000 CpG genome sites from VAT samples from women with obesity undergoing gastric bypass (n = 18), and classified as suffering from type 2 diabetes (T2D) or not (no type 2 diabetes, NT2D), were analyzed using DNA methylation arrays...
2017: PloS One
https://www.readbyqxmd.com/read/29228048/trends-in-the-management-levels-of-metabolic-risk-factors-in-middle-aged-and-elderly-patients-with-type-2-diabetes-mellitus-the-korean-national-health-and-nutrition-examination-survey-1998-2014
#4
Sukyung Cho, Haeun Jang, Kyong Park
The present study examined the temporal trends in the management of blood pressure, glucose, and lipid levels among middle-aged and elderly patients with type 2 diabetes using data from the Korean National Health and Nutrition Examination Survey (1998-2014). A total of 3,689 patients with diabetes were included and divided into middle-aged (30-64 years old) and elderly (≥65 years old) groups. Demographic and lifestyle data were obtained using a self-reported questionnaire, and trained medical staff obtained fasting blood samples and blood pressure data...
2017: PloS One
https://www.readbyqxmd.com/read/29228027/an-insulin-resistance-associated-neural-correlate-of-impulsivity-in-type-2-diabetes-mellitus
#5
Kristen L Eckstrand, Nishit Mummareddy, Hakmook Kang, Ronald Cowan, Minchun Zhou, David Zald, Heidi J Silver, Kevin D Niswender, Malcolm J Avison
Central insulin resistance (IR) influences striatal dopamine (DA) tone, an important determinant of behavioral self-regulation. We hypothesized that an association exists between the degree of peripheral IR and impulse control, mediated by the impact of IR on brain circuits controlling the speed of executing "go" and/or "stop" responses. We measured brain activation and associated performance on a stop signal task (SST) in obese adults with type 2 diabetes (age, 48.1 ± 6.9 yrs (mean ± SD); BMI, 36.5 ± 4...
2017: PloS One
https://www.readbyqxmd.com/read/29227971/association-of-1082a-g-polymorphism-in-the-interleukin-10-gene-with-estimated-glomerular-filtration-rate-in-type-2-diabetes
#6
Evelise Regina Polina, Bruna Letícia da Silva Pereira, Daisy Crispim, Renan Cesar Sbruzzi, Luis Henrique Canani, Kátia Gonçalves Dos Santos
BACKGROUND/AIMS: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the -1082A>G polymorphism is associated with DKD in white Brazilians with type 2 diabetes mellitus. METHODS: Genotyping was done by real-time polymerase chain reaction for 597 type 2 diabetic outpatients...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29227755/glycemic-variability-percentage-a-novel-method-for-assessing-glycemic-variability-from-continuous-glucose-monitor-data
#7
Thomas A Peyser, Andrew K Balo, Bruce A Buckingham, Irl B Hirsch, Arturo Garcia
BACKGROUND: High levels of glycemic variability are still observed in most patients with diabetes with severe insulin deficiency. Glycemic variability may be an important risk factor for acute and chronic complications. Despite its clinical importance, there is no consensus on the optimum method for characterizing glycemic variability. METHOD: We developed a simple new metric, the glycemic variability percentage (GVP), to assess glycemic variability by analyzing the length of the continuous glucose monitoring (CGM) temporal trace normalized to the duration under evaluation...
December 11, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29227582/role-of-the-sodium-hydrogen-exchanger-in-mediating-the-renal-effects-of-drugs-commonly-used-in-the-treatment-of-type-2-diabetes
#8
REVIEW
Milton Packer
Diabetes is characterized by an increased activity of the sodium-hydrogen exchanger (NHE) in the glomerulus and renal tubules, which contributes importantly to the development of nephropathy. Despite the established role played by the exchanger in experimental studies, it has not been specifically targeted by those seeking to develop novel pharmacological treatments for diabetes. This review demonstrates that many existing drugs that are commonly prescribed to patients with diabetes act on the NHE1 and NHE3 isoforms in the kidney...
December 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29227579/obesity-type-2-diabetes-increases-inflammation-periosteal-reactive-bone-formation-and-osteolysis-during-staphylococcus-aureus-implant-associated-bone-infection
#9
Christopher W Farnsworth, Eric M Schott, Abigail M Benvie, Jacob Zukoski, Stephen L Kates, Edward M Schwarz, Steven R Gill, Michael J Zuscik, Robert A Mooney
Obese and type 2 diabetic (T2D) patients have a 5-fold increased rate of infection following placement of an indwelling orthopaedic device. Though implant infections are associated with inflammation, periosteal reactive bone formation and osteolysis, the effect of obesity/T2D on these complicating factors has not been studied. To address this question, C57BL/6J mice were fed a high fat diet (60% Kcal from fat) to induce obesity/T2D, or a control diet (10% Kcal from fat) for three months, and challenged with a transtibial pin coated with a bioluminescent USA300 strain of S...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29227575/effect-of-a-single-dose-of-the-dpp-4-inhibitor-sitagliptin-on-%C3%AE-cell-function-and-incretin-hormone-secretion-after-meal-ingestion-in-healthy-volunteers-and-drug-na%C3%A3-ve-well-controlled-type-2-diabetes-subjects
#10
Wathik Alsalim, Olga Göransson, Richard D Carr, Roberto Bizzotto, Andrea Tura, Giovanni Pacini, Andrea Mari, Bo Ahrén
To explore the effects of a single dose of the DPP-4 inhibitor sitagliptin on glucose-standardized insulin secretion and β-cell glucose sensitivity after meal ingestion, twelve healthy- and twelve drug naïve well-controlled type 2 diabetes subjects (T2D; mean HbA1c 43 mmol/mol, 6.2%) received sitagliptin (100mg) or placebo before a meal (525 kcal). β-cell function was measured as the insulin secretory rate at a standardized glucose concentration and the β-cell glucose sensitivity (the slope between glucose and insulin secretory rate)...
December 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29227571/comparative-effectiveness-of-metformin-monotherapy-in-extended-release-and-immediate-release-formulations-for-the-treatment-of-type-2-diabetes-in-treatment-na%C3%A3-ve-chinese-patients-analysis-of-results-from-the-consent-trial
#11
Linong Ji, Jing Liu, Jing Yang, Yufeng Li, Li Liang, Dalong Zhu, Quanmin Li, Tianrong Ma, Haiyan Xu, Yanlan Yang, Jiaoe Zeng, Bo Feng, Shen Qu, Yiming Li, Lizhen Ma, Shanshan Lin, Jianping Wang, Wei Li, Weihong Song, Xiaoxing Li, Yong Luo, Shugang Xi, Mei Lin, Yu Liu, Zerong Liang
AIMS: Metformin treatment for type 2 diabetes (T2DM) can be limited by gastrointestinal (GI) adverse events (AEs), resulting in treatment discontinuation. We investigated whether once-daily metformin extended release (XR) is superior in terms of GI tolerability, with non-inferior efficacy, compared with thrice-daily metformin immediate release (IR) in treatment-naïve Chinese patients with T2DM. MATERIALS AND METHODS: This prospective, open-label, randomized, multicenter, phase IV interventional study enrolled Chinese T2DM patients to receive either metformin XR or metformin IR with a 2-week screening period, 16-week treatment period, and 2-week follow-up period without treatment...
December 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29227535/antidiabetic-and-lipid-lowering-effects-of-the-polyphenol-extracts-from-the-leaves-of-clausena-lansium-lour-skeels-on-streptozotocin-induced-type-2-diabetic-rats
#12
Fansheng Kong, Zhipeng Su, Xiaoming Guo, Feng Zeng, Yongguang Bi
Clausena lansium (Lour.) Skeels (Wampee) is widely grown in China and considered as a healthy fruit. Its leaves are also considered as traditional herbs. This study analyzed polyphenol compounds in polyphenol extracts of the leaves C. lansium (lour.) Skeels (PEL) and investigated the protective effect of PEL against hyperglycemia and hyperlipidemia in T2DM rats. The result showed that PEL is composed mainly of gallic acid, chlorogenic acid, coffee acid, ferulic acid, and rutin. PEL could obviously relieve some symptoms of T2DM rats, including emaciation, hyperhidrosis, polyphagia, diuresis, liver swelling, kidney, and pancreas hypertrophy, as well as reduce fasting blood glucose...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29227493/prophylactic-role-of-vitamin-k-supplementation-on-vascular-inflammation-in-type-2-diabetes-by-regulating-the-nf-%C3%AE%C2%BAb-nrf2-pathway-via-activating-gla-proteins
#13
Anjum Dihingia, Dibyajyoti Ozah, Pranab Kumar Baruah, Jatin Kalita, Prasenjit Manna
There is no previous study that has examined the relationship between circulating vitamin K1 (VK1) and vascular inflammation in type 2 diabetes (T2D). This study aims to examine the hypothesis that circulating VK1 deficiency may be associated with higher inflammation and insulin resistance in T2D patients and that VK1 supplementation regulates the NF-κB/Nrf2 pathway via activating VK-dependent Gla proteins and reduces vascular inflammation. The results showed that plasma VK1 levels were significantly lower and MCP-1, fasting glucose, HbA1c, and insulin resistance (HOMA-IR) were significantly higher in T2D patients compared to those in the controls...
December 11, 2017: Food & Function
https://www.readbyqxmd.com/read/29227039/mid-term-results-of-bariatric-surgery-in-morbidly-obese-japanese-patients-with-slow-progressive-autoimmune-diabetes
#14
Kohei Uno, Yosuke Seki, Kazunori Kasama, Kotaro Wakamatsu, Kenkichi Hashimoto, Akiko Umezawa, Katsuhiko Yanaga, Yoshimochi Kurokawa
INTRODUCTION: Bariatric surgery is recognized as an effective treatment for type 2 diabetes mellitus, but data on its efficacy for type 1 diabetes mellitus, especially slowly progressive insulin-dependent diabetes mellitus, are limited. METHODS: We investigated five Japanese patients with slowly progressive insulin-dependent diabetes mellitus who underwent bariatric surgery at our center. RESULTS: Five morbidly obese glutamic acid decarboxylase antibody-positive diabetic patients underwent two different types of bariatric surgery...
December 11, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29226787/bayesian-proportional-hazards-model-with-latent-variables
#15
Deng Pan, Kai Kang, Chunjie Wang, Xinyuan Song
We consider a joint modeling approach that incorporates latent variables into a proportional hazards model to examine the observed and latent risk factors of the failure time of interest. An exploratory factor analysis model is used to characterize the latent risk factors through multiple observed variables. In commonly used confirmatory factor analysis, the number of latent variables and their observed indicators are specified prior to analysis. By contrast, the exploratory factor analysis model allows such information to be fully determined by the data...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29226694/effectiveness-of-motivational-interviewing-for-improving-physical-activity-self-management-for-adults-with-type-2-diabetes-a-review
#16
Patricia Davern Soderlund
Objectives This review examines the effectiveness of motivational interviewing for physical activity self-management for adults diagnosed with diabetes mellitus type 2. Motivational interviewing is a patient centered individually tailored counseling intervention that aims to elicit a patient's own motivation for health behavior change. Review questions include (a) How have motivational interviewing methods been applied to physical activity interventions for adults with diabetes mellitus type 2? (b) What motivational interviewing approaches are associated with successful physical activity outcomes with diabetes mellitus 2? Methods Database searches used PubMed, CINAHL, and PsycINFO for the years 2000 to 2016...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/29226685/size-effect-on-lipid-nanocapsules-mediated-glp-1-secretion-from-enteroendocrine-l-cells
#17
Yining Xu, Dario Carradori, Mireille Alhouayek, Giulio G Muccioli, Patrice D Cani, Veronique Preat, Ana Beloqui
L cells are enteroendocrine cells located throughout the gastrointestinal tract that secrete physiologically important peptides. The most characterized peptides secreted by L cells are the peptide YY (PYY) and the glucagon-like peptide (GLP) -1 and -2. These peptides are released rapidly into the circulation after oral nutrient ingestion. Recently, lipid-based nanoparticles (NP) have been described as triggers for GLP-1 secretion by L cells. NP physicochemical properties play a key role in the NP-cell interaction, and drive NP cell internalization...
December 11, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29226654/evaluation-of-hepcidin-and-atherosclerosis-in-dialysis-patients
#18
Victor Manolov, Julia Petrova, Boris Bogov, Savina Hadjidekova, Vasil Vasilev, Dyana Yonova, Maria Petrova, Todor Kunchev, Yavor Jelev, Petar Jeliazkov, Borislav Marinov, Ivo Bogov, Zlatina Gramatikova, Silviya Voleva, Kamen Tzatchev, Latchezar Traykov
BACKGROUND: Chronic kidney disease (CKD) is a condition that involves 10% - 15% of population worldwide, which increases the risk of cardio-vascular diseases (CVD). Chronic kidney disease is one of the main reasons for illness and mortality in the world. Chronic kidney disease is a serious health problem caused by involvement of a large number of patients with kidney injury, especially in industrial countries. Among the main reasons for this are population living longer and the number of diseases in elderly persons, such as diabetes mellitus type 2, hypertension, and cardio-vascular diseases...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226514/hospital-admission-in-children-and-adolescents-with-or-without-type-1-diabetes-from-germany-an-analysis-of-statutory-health-insurance-data-on-12-million-subjects
#19
Barbara Bohn, Anke Schwandt, Peter Ihle, Andrea Icks, Joachim Rosenbauer, Beate Karges, Reinhard W Holl
OBJECTIVE: To compare the chance of hospital admissions in children and adolescents with type 1 diabetes (T1D) to that without T1D from Germany. METHODS: Data were provided by the German information system for health care data which contains information on all patients with a statutory health insurance. The years 2009 and 2011 were considered. Children and adolescents (0 to ≤19 years of age; n = 12 030 242) were included. Unadjusted odds ratios (ORs) with 95% confidence interval (95% CI) were used to compare the hospitalization rate for patients with (n = 26 444) or without T1D (12 003 798)...
December 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29226116/alcohol-consumption-in-diabetic-patients-with-nonalcoholic-fatty-liver-disease
#20
Preya J Patel, David Smith, Jason P Connor, Leigh U Horsfall, Kelly L Hayward, Fabrina Hossain, Suzanne Williams, Tracey Johnson, Katherine A Stuart, Nigel N Brown, Nivene Saad, Andrew D Clouston, Katharine M Irvine, Anthony W Russell, Patricia C Valery, Elizabeth E Powell
Aim: To examine the association between lifetime alcohol consumption and significant liver disease in type 2 diabetic patients with NAFLD. Methods: A cross-sectional study assessing 151 patients with NAFLD at risk of clinically significant liver disease. NAFLD fibrosis severity was classified by transient elastography; liver stiffness measurements ≥8.2 kPa defined significant fibrosis. Lifetime drinking history classified patients into nondrinkers, light drinkers (always ≤20 g/day), and moderate drinkers (any period with intake >20 g/day)...
2017: Canadian Journal of Gastroenterology & Hepatology
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