keyword
https://read.qxmd.com/read/38491339/effect-of-post-transplant-diabetes-mellitus-on-cardiovascular-events-and-mortality-a-single-center-retrospective-cohort-study
#21
JOURNAL ARTICLE
Uğur Ünlütürk, Tolga Yıldırım, Merve Savaş, Seda Hanife Oğuz, Büşra Fırlatan, Deniz Yüce, Nesrin Damla Karakaplan, Cemile Selimova, Rahmi Yılmaz, Yunus Erdem, Miyase Bayraktar
PURPOSE: This study aims to investigate the impact of post-transplant diabetes mellitus (PTDM) on cardiovascular events, graft survival, and mortality and to determine the risk factors involved in developing PTDM. METHODS: A total of 703 patients who underwent kidney transplantation were included in the study. The total sample was subdivided into three groups: (i) patients with PTDM; (ii) patients who had diabetes before the transplantation (DM); and (iii) patients without diabetes (NoDM)...
March 15, 2024: Endocrine
https://read.qxmd.com/read/38491114/plasma-extracellular-vesicle-micrornas-reflecting-the-therapeutic-effect-of-the-cbp-%C3%AE-catenin-inhibitor-pri-724-in-patients-with-liver-cirrhosis
#22
JOURNAL ARTICLE
Mayu Yoshida, Juntaro Matsuzaki, Koji Fujita, Masamichi Kimura, Tomohiro Umezu, Noi Tokuda, Tomoko Yamaguchi, Masahiko Kuroda, Takahiro Ochiya, Yoshimasa Saito, Kiminori Kimura
There is an unmet need for antifibrotic therapies to prevent the progression of liver cirrhosis. Previously, we conducted an exploratory trial to assess the safety and antifibrotic efficacy of PRI-724, a selective CBP/β-catenin inhibitor, in patients with liver cirrhosis. PRI-724 was well tolerated and exerted a potential antifibrotic effect. Here, we investigated whether the profiles of circulating microRNAs packaged in extracellular vesicles (EV-miRNAs) are associated with responses to liver fibrosis treatments...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38491051/an-adenosine-derivative-promotes-mitochondrial-supercomplexes-reorganization-and-restoration-of-mitochondria-structure-and-bioenergetics-in-a-diethylnitrosamine-induced-hepatocellular-carcinoma-model
#23
JOURNAL ARTICLE
Rosendo García-Carrillo, Francisco A Molina-Pelayo, David Zarate-Lopez, Alejandro Cabrera-Aguilar, Bibiana Ortega-Domínguez, Mariana Domínguez-López, Natalia Chiquete-Félix, Adan Dagnino-Acosta, Gabriela Velasco-Loyden, Enrique Chávez, Luis Castro-Sánchez, Victoria Chagoya de Sánchez
Hepatocellular carcinoma (HCC) progression is associated with dysfunctional mitochondria and bioenergetics impairment. However, no data about the relationship between mitochondrial supercomplexes (hmwSC) formation and ATP production rates in HCC are available. Our group has developed an adenosine derivative, IFC-305, which improves mitochondrial function, and it has been proposed as a therapeutic candidate for HCC. We aimed to determine the role of IFC-305 on both mitochondrial structure and bioenergetics in a sequential cirrhosis-HCC model in rats...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490954/prophylactic-enoxaparin-dosing-using-anti-factor-xa-levels-in-hepatic-surgery-patients-a-pilot-study
#24
JOURNAL ARTICLE
Samuel Coster, Ali Shammout, Michael Chaney, Kyra Folkert, Kent Grosh, Saad Shebrain, Gitonga Munene
This study examines the safety and efficacy of using peak anti-Xa levels to achieve prophylactic enoxaparin (Lovenox, Sanofi-Aventis) levels in patients who underwent hepatic surgery. Prospectively enrolled patients undergoing major and minor hepatic procedures received postoperative enoxaparin dosing. The enoxaparin dose was adjusted to attain a peak anti-Xa level ≥ 0.20 U/ml. This group was compared to a historical cohort of patients who underwent similar procedures and received standard postoperative VTE chemoprophylaxis dosing...
March 15, 2024: American Surgeon
https://read.qxmd.com/read/38490890/biomimetic-hepatic-lobules-from-three-dimensional-imprinted-cell-sheets
#25
JOURNAL ARTICLE
Jinglin Wang, Danqing Huang, Hanxu Chen, Yuanjin Zhao
Liver-tissue engineering has proven valuable in treating liver diseases, but the construction of liver tissues with high fidelity remains challenging. Here, we present a novel three-dimensional (3D)-imprinted cell-sheet strategy for the synchronous construction of biomimetic hepatic microtissues with high accuracy in terms of cell type, density, and distribution. To achieve this, the specific composition of hepatic cells in a normal human liver was determined using a spatial proteogenomics dataset. The data and biomimetic hepatic micro-tissues with hexagonal hollow cross-sections indicate that cell information was successfully generated using a homemade 3D-imprinted device for layer-by-layer imprinting and assembling the hepatic cell sheets...
February 28, 2024: Science Bulletin
https://read.qxmd.com/read/38490825/the-role-of-pcsk9-in-metabolic-dysfunction-associated-steatotic-liver-disease-and-its-impact-on-bariatric-surgery-outcomes
#26
JOURNAL ARTICLE
Daniel Castellano-Castillo, María Ángeles Núñez-Sánchez, Andrés Balaguer-Román, María Antonia Martínez-Sánchez, Virginia Esperanza Fernández-Ruiz, Mercedes Ferrer-Gómez, Carlos Manuel Martínez, María Dolores Frutos, María Isabel Queipo-Ortuño, Fernando Cardona, Bruno Ramos-Molina
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely tied to obesity. The degree ranges from steatosis (MASL) and steatohepatitis (MASH) to liver cirrhosis. PCSK9 controls cholesterol and lipid particle transport to the liver. PCSK9 might interfere with the pathophysiology of MASLD and bariatric surgery (BS) outcomes of patients with MASLD. OBJECTIVES: Evaluate the relationship between serum and hepatic PCSK9 levels with the degree of MASLD and the metabolic outcome of BS...
February 6, 2024: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/38490526/microcystin-lr-and-polystyrene-microplastics-jointly-lead-to-hepatic-histopathological-damage-and-antioxidant-dysfunction-in-male-zebrafish
#27
JOURNAL ARTICLE
Wang Lin, Fen Hu, Fang Liu, Ling Liao, Ling Ling, Li Li, Jifeng Yang, Pinhong Yang
The co-occurrence of cyanobacterial blooms and nano-microplastic pollution in the water is becoming an emerging risk. To assess the combined hepatotoxicity of microcystin-LR (MC-LR) and polystyrene microplastics (PSMPs) on zebrafish (Danio rerio), male adult zebrafish were exposed to single MC-LR (0, 1, 5, 25 μg/L) and a mixture of MC-LR and PSMPs (100 μg/L). After 60 d exposure, the results indicated that PSMPs significantly increased the MC-LR bioaccumulation in the livers in contrast to the single 25 μg/L MC-LR treatment group...
March 13, 2024: Environmental Pollution
https://read.qxmd.com/read/38490364/modified-radiation-lobectomy-strategy-of-radioembolization-for-right-sided-unresectable-primary-liver-tumors
#28
JOURNAL ARTICLE
Qian Yu, Yating Wang, Ethan Ungchusri, Anjana Pillai, Chih-Yi Liao, John Fung, Diego DiSabato, Talia Baker, Mikin Patel, Thuong Van Ha, Osman Ahmed
PURPOSE: To assess the safety and effectiveness of using modified radiation lobectomy (mRL) to treat primary hepatic tumors located in the right hepatic lobe (segments V-VIII) and determine future liver remnant (FLR) hypertrophy. METHODS: A retrospective review was performed at a single institution to include 19 consecutive patients (7 Female, 12 Male) who underwent single-session mRL for right sided primary hepatic tumors: 15 received segmentectomy plus lobectomy (segmental dose >190 Gy and lobar dose >80 Gy); 4 were treated with the double-segmental approach (dominant segments >190 Gy and non-dominant segments > 80 Gy)...
March 13, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38490157/therapeutic-potential-of-angelica-sinensis-in-addressing-organ-fibrosis-a-comprehensive-review
#29
REVIEW
Xiaodong Zhi, Chunzhen Ren, Qianrong Li, Huaqing Xi, Dong Li, Qilin Chen, Xinfang Lv, Xiang Gao, Xue Wu, Chunling Wang, Bing Jiang, Zhongnan Mao, Hugang Jiang, Kai Liu, Xinke Zhao, Yingdong Li
Fibrosis-related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern anti-fibrosis drugs in clinical practice. However, Chinese medicine has a certain beneficial effect on the treatment of such diseases. Angelica sinensis, with its considerable medicinal value, has garnered attention for its anti-fibrosis properties in recent investigations...
March 13, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38490091/chronic-inflammatory-demyelinating-polyneuropathy-and-hev-antibody-status-a-case-control-study-from-lazio-italy
#30
JOURNAL ARTICLE
Federica Moret, Enea Spada, Marco Ceccanti, Laura Libonati, Edoardo D'Andrea, Umbertina Villano, Elisabetta Madonna, Paola Chionne, Alberto Carocci, Giulio Pisani, Laura Fionda, Giovanni Antonini, Antonio Petrucci, Roberto Bruni, Anna Rita Ciccaglione, Gloria Taliani, Marco Rivano Capparuccia, Eduardo Nobile-Orazio, Maurizio Inghilleri, Chiara Cambieri
INTRODUCTION: Few studies have pointed to the possible role of infectious diseases in triggering Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). Given the association of Hepatitis E Virus (HEV) with Guillain Barrè syndrome, we conducted a case-control study to determine the possible association of HEV infection with CIDP, analyzing possible risk factors for acquiring HEV infection in both CIDP patients and controls. MATERIALS AND METHODS: 82 CIDP and 260 from the general population have provided some personal information (demographics, anamnestic data and recognized risk factors for HEV infection) and underwent venipuncture blood sampling for virological assays testing for anti-HEV IgG and IgM with ELISA and RNA-HEV performing RT-PCR...
March 12, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38489995/iron-homeostasis-in-older-adults-balancing-nutritional-requirements-and-health-risks
#31
REVIEW
Rola S Zeidan, Matthew Martenson, Javier A Tamargo, Christian McLaren, Armin Ezzati, Yi Lin, Jae Jeong Yang, Hyung-Suk Yoon, Taylor McElroy, James F Collins, Christiaan Leeuwenburgh, Robert T Mankowski, Stephen Anton
Iron plays a crucial role in many physiological processes, including oxygen transport, bioenergetics, and immune function. Iron is assimilated from food and also recycled from senescent red blood cells. Iron exists in two dietary forms: heme (animal based) and non-heme (mostly plant based). The body uses iron for metabolic purposes, and stores the excess mainly in splenic and hepatic macrophages. Physiologically, iron excretion in humans is inefficient and not highly regulated, so regulation of intestinal absorption maintains iron homeostasis...
March 14, 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38489890/paeoniflorin-promotes-ppar%C3%AE-expression-to-suppress-hscs-activation-by-inhibiting-ezh2-mediated-histone-h3k27-trimethylation
#32
JOURNAL ARTICLE
Tian Lan, Ping Li, Si-Jia Zhang, Shi-Yu Liu, Xi-Xi Zeng, Fang Chai, Yu-Hua Tong, Zhu-Jun Mao, Si-Wei Wang
BACKGROUND: The alleviating effect of paeoniflorin (Pae) on liver fibrosis has been established; however, the molecular mechanism and specific target(s) underlying this effect remain elusive. PURPOSE: This study was to investigate the molecular mechanism underlying the regulatory effect of Pae on hepatic stellate cells (HSCs) activation in liver fibrosis, with a specific focus on the role of Pae in modulating histone methylation modifications. METHODS: The therapeutic effect of Pae was evaluated by establishing in vivo and in vitro models of carbon tetrachloride (CCl4 )-induced mice and transforming growth factor β1 (TGF-β1 )-induced LX-2 cells, respectively...
February 24, 2024: Phytomedicine
https://read.qxmd.com/read/38489889/jaceosidin-attenuates-the-progression-of-hepatic-fibrosis-by-inhibiting-the-vgll3-hmgb1-tlr4-signaling-pathway
#33
JOURNAL ARTICLE
Youli Yao, Xiaoling Zuo, Feng Shao, Kexin Yu, Quanquan Liang
BACKGROUND: Jaceosidin (JA) is a natural flavone extracted from Artemisia that is used as a food and traditional medicinal herb. It has been reported to possess numerous biological activities. However, the regulatory mechanisms underlying amelioration of hepatic fibrosis remain unclear. HYPOTHESIS/PURPOSE: We hypothesized that jaceosidin acid (JA) modulates hepatic fibrosis and inflammation. METHODS: Thioacetamide (TAA) was used to establish an HF mouse model...
March 10, 2024: Phytomedicine
https://read.qxmd.com/read/38489847/corn-oligopeptide-alleviates-nonalcoholic-fatty-liver-disease-by-regulating-the-sirtuin-signaling-pathway
#34
JOURNAL ARTICLE
Yali Xu, Ting Su, Hricha Mishra, Reiko Ando, Yutaka Furutani, Jun Lu, Muyi Cai, Harukazu Suzuki, Wenkui Yu, Xian-Yang Qin
Nonalcoholic fatty liver disease (NAFLD) represents the most prevalent type of chronic liver disease, spanning from simple steatosis to nonalcoholic steatohepatitis (NASH). Corn oligopeptide (CP) is a functional peptide known for its diverse pharmacological effects on metabolism. In this study, we evaluated the protective activity of CP against fatty liver disease. Oral administration of CP significantly reduced body weight gain by 2.95%, serum cholesterol by 22.54%, and liver injury, as evidenced by a reduction of 32...
March 15, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38489722/apathetic-graves-disease-with-severe-hepatic-and-renal-dysfunction-induced-by-covid-19-infection-case-report-and-literature-review
#35
JOURNAL ARTICLE
Liting Deng, Yingtong Zhang, Huilin Sun
RATIONALE: A rare and intractable case of apathetic Graves' disease (GD) with severe liver and kidney damage induced by coronavirus disease 2019 (COVID-19) carries a certain risk of missing diagnosis and delayed treatment during the COVID-19 pandemic. PATIENT CONCERN: A 60-year-old female patient developed anorexia, exhaustion, jaundice, nausea, and vomiting 10 days after COVID-19 infection. She was admitted to the Infectious Diseases Department because of recurring symptoms for more than a month...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489699/gynura-segetum-induces-hepatic-sinusoidal-obstruction-syndrome-in-a-child-a-case-report
#36
JOURNAL ARTICLE
Qian Zheng, Haiyang Zhang
RATIONALE: Hepatic sinusoidal obstruction syndrome (HSOS), which includes hepatic stasis and portal hypertension, is a rare vascular disorder of the liver. It is often associated with hematopoietic stem cell transplantation. It is also possible to treat this disease using Chinese herbal medicines that contain pyrrolizidine alkaloids (PAs). This disease is extremely rare in children and poses a serious threat to their health. To our knowledge, this is the first case of HSOS in a child with PAs...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489674/idiopathic-mesenteric-phlebosclerosis-occurring-in-a-patient-with-liver-cirrhosis-a-case-report
#37
JOURNAL ARTICLE
Congjie Zhang, Haijun Huang, Beibei Guo
BACKGROUND: Idiopathic mesenteric phlebosclerosis (IMP) is a rare gastrointestinal disease with unclear etiology and pathogenesis. IMP occurring in a patient with liver cirrhosis is more scarcely reported than independent IMP. In this study, we reported a case of IMP occurring in a patient with liver cirrhosis, so as to provide a reference for understanding liver cirrhosis with IMP. METHOD: A 63-year-old man with liver cirrhosis was admitted in the hospital's department of infectious disease because of fatigue and constipation for 1 month...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489662/relation-between-non-alcoholic-fatty-liver-disease-and-carotid-artery-intimal-media-thickness-as-a-surrogate-for-atherosclerosis-a-systematic-review-and-meta-analysis
#38
JOURNAL ARTICLE
Hazem Abosheaishaa, Mahmoud Nassar, Omar Abdelhalim, Ammar Ayman Bahbah, Sharif Abbas, Samah M Morsi, Muhammad Ghallab, Zakaria Alagha, Ahmed Omran, Khaled Elfert, Praneeth Bandaru, Arnold Nongmoh Forlemu, Madhavi Reddy
BACKGROUND AND OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis without heavy alcohol consumption or other chronic conditions, encompasses a spectrum from non-alcoholic fatty liver to non-alcoholic steatohepatitis leading to cirrhosis. This analysis aimed to investigate the correlation between NAFLD and carotid intimal media thickness (C-IMT), a non-invasive surrogate for atherosclerosis. METHODOLOGY: Database searches, including PubMed, EMBASE and Cochrane Library, yielded studies up to April 2023...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38489523/aasld-practice-guideline-on-blood-based-non-invasive-liver-disease-assessments-of-hepatic-fibrosis-and-steatosis
#39
JOURNAL ARTICLE
Richard K Sterling, Keyur Patel, Andres Duarte-Rojo, Sumeet K Asrani, Mouaz Alsawas, Jonathan Dranoff, Maria Isabel Fiel, M Hassan Murad, Daniel H Leung, Deborah Levine, Tamar H Taddei, Bachir Taouli, Don C Rockey
No abstract text is available yet for this article.
March 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38489518/aasld-practice-guideline-on-imaging-based-non-invasive-liver-disease-assessments-of-hepatic-fibrosis-and-steatosis
#40
JOURNAL ARTICLE
Richard K Sterling, Andres Duarte-Rojo, Keyur Patel, Sumeet K Asrani, Mouaz Alsawas, Jonathan Dranoff, Maria Isabel Fiel, M Hassan Murad, Daniel H Leung, Deborah Levine, Tamar H Taddei, Bachir Taouli, Don C Rockey
No abstract text is available yet for this article.
March 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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