keyword
https://read.qxmd.com/read/38498089/robotic-versus-open-hepatic-arterial-infusion-pump-placement-for-unresectable-intrahepatic-cholangiocarcinoma
#1
JOURNAL ARTICLE
Britte H E A Ten Haaft, Stijn Franssen, Roderick W J J van Dorst, Merve Rousian, Gabriela Pilz da Cunha, Roeland F de Wilde, Joris I Erdmann, Bas Groot Koerkamp, Jeroen Hagendoorn, Rutger-Jan Swijnenburg
BACKGROUND: Hepatic arterial infusion pump (HAIP) chemotherapy is an effective treatment for patients with unresectable intrahepatic cholangiocarcinoma (iCCA). HAIP chemotherapy requires a catheter inserted in the gastroduodenal artery and a subcutaneous pump. The catheter can be placed using an open or robotic approach. OBJECTIVE: This study aimed to compare perioperative outcomes of robotic versus open HAIP placement in patients with unresectable iCCA. METHODS: We analyzed patients with unresectable iCCA included in the PUMP-II trial from January 2020 to September 2022 undergoing robotic or open HAIP placement at Amsterdam UMC, Erasmus MC, and UMC Utrecht...
March 18, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38498004/potential-i-nos-arg-1-switch-with-nlrp3-and-parasitic-load-down-regulation-in-experimental-schistosoma-mansoni-infection-via-chloroquine-repurposing
#2
JOURNAL ARTICLE
Marwa A Hasby Saad, Esraa G El-Saadi, Dareen A Ali, Mona M Watany, Mohammed M Eid
In previous studies, the inhibitory effect of chloroquine on NLRP3 inflammasome and heme production was documented. This may be employed as a double-bladed sword in schistosomiasis (anti-inflammatory and parasiticidal). In this study, chloroquine's impact on schistosomiasis mansoni was investigated. The parasitic load (worm/egg counts and reproductive capacity index [RCI]), i-Nos/Arg-1 expression, splenomegaly, hepatic insult and NLRP3-immunohistochemical expression were assessed in infected mice after receiving early and late repeated doses of chloroquine alone or dually with praziquantel...
March 2024: Parasite Immunology
https://read.qxmd.com/read/38497934/clinical-criteria-accurately-diagnose-severe-but-not-moderate-alcohol-associated-hepatitis-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Nipun Verma, Rohit Mehtani, Jacob Martin Haiar, Pranita Pradhan, Ajay Duseja, Gene Young Im, Ashwani K Singal
BACKGROUND: The precision of clinical criteria and the utility of liver biopsy for diagnosis or prognosis remain unclear in patients with alcohol-associated hepatitis (AH). We systematically reviewed the literature to answer these questions. METHODS: Four databases were searched for studies describing the precision of clinical criteria (National Institute on Alcohol Abuse and Alcoholism, European Association for Study of Liver, or classical) and the role of histology in AH...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497932/granulomatous-liver-diseases
#4
JOURNAL ARTICLE
Maria Mironova, Harish Gopalakrishna, Gian Rodriguez Franco, Steven M Holland, Christopher Koh, David E Kleiner, Theo Heller
A granuloma is a discrete collection of activated macrophages and other inflammatory cells. Hepatic granulomas can be a manifestation of localized liver disease or be a part of a systemic process, usually infectious or autoimmune. A liver biopsy is required for the detection and evaluation of granulomatous liver diseases. The prevalence of granulomas on liver biopsy varies from 1% to 15%. They may be an incidental finding in an asymptomatic individual, or they may represent granulomatous hepatitis with potential to progress to liver failure, or in chronic disease, to cirrhosis...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497931/racial-and-ethnic-disparities-in-alcohol-associated-liver-disease-in-the-united-states-a-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Ahmad Anouti, Karim Seif El Dahan, Nicole E Rich, Jeremy Louissaint, William M Lee, Sarah R Lieber, Juan Pablo Arab, Bill Y Zhang, Mausam J Patel, Chanattha Thimphittaya, Luis Antonio Díaz, Dyanna L Gregory, Julia Kozlitina, Lisa B VanWagner, Andrea C King, Mack C Mitchell, Amit G Singal, Thomas G Cotter
BACKGROUND: Alcohol-associated liver disease (ALD), encompassing alcohol-associated hepatitis and alcohol-associated cirrhosis, is rising in the United States. Racial and ethnic disparities are evident within ALD; however, the precise nature of these disparities is poorly defined. METHODS: We conducted a search of the PubMed/MEDLINE and EMBASE databases to identify studies published from inception through September 2023 that reported ALD incidence, prevalence, and mortality within the United States, stratified by race and ethnicity...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497873/hepatitis-e-virus-infection-increases-the-risk-of-obstetric-complications-and-perinatal-adverse-outcomes-in-pregnant-women-with-chronic-hepatitis-b-virus-infection
#6
JOURNAL ARTICLE
C Chen, M-L Wang, W-X Li, X Qi, Q Li, L Chen
OBJECTIVE: Hepatitis E virus (HEV) infection may occur in pregnant women who had chronic hepatitis B virus (HBV) infection. This study aimed to evaluate whether HEV-HBV co-infection increases the risk of obstetric complications and perinatal adverse outcomes in pregnant women. PATIENTS AND METHODS: We investigated the clinical data of 3,251 pregnant women with chronic HBV infection. The obstetric complications and perinatal adverse outcomes were compared between patients with HEV-HBV co-infection and patients who had pure chronic HBV infection...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497865/therapeutic-potential-of-ramipril-losartan-and-spironolactone-against-sepsis-associated-liver-tissue-injury-induced-by-cecal-ligation-and-puncture-in-rats
#7
JOURNAL ARTICLE
A Al-Kadi, M El-Daly, N F G El-Tahawy, O Fahmi, A B Abdel-Naim, M M A Khalifa, A F Ahmed
OBJECTIVE: Sepsis-associated liver injury is responsible for the high morbidity and mortality rates seen with septic shock. Activation of the renin-angiotensin-aldosterone system (RAAS) is an essential counteractive mechanism during the hypotensive phase of sepsis; however, excessive activation is associated with exaggerated pro-oxidant and inflammatory response, which aggravates organ damage. This study aimed to evaluate the effect of RAAS inhibition on sepsis-induced liver damage. MATERIALS AND METHODS: The cecal ligation and puncture (CLP) model was employed as a model of sepsis...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497497/annual-risk-of-hepatitis-e-virus-infection-and-seroreversion-insights-from-a-serological-cohort-in-sitakunda-bangladesh
#8
JOURNAL ARTICLE
Amy Dighe, Ashraful Islam Khan, Taufiqur Rahman Bhuiyan, Md Taufiqul Islam, Zahid Hasan Khan, Ishtiakul Islam Khan, Juan Dent Hulse, Shakeel Ahmed, Mamunur Rashid, Md Zakir Hossain, Rumana Rashid, Sonia T Hegde, Emily S Gurley, Firdausi Qadri, Andrew S Azman
No abstract text is available yet for this article.
March 18, 2024: Epidemiology and Infection
https://read.qxmd.com/read/38497081/amino-acid-pattern-reveals-multi-functionality-of-orf3-protein-from-hev
#9
JOURNAL ARTICLE
Zoya Shafat, Asimul Islam, Shama Parveen
The smallest open reading frame (ORF) encoded protein ORF3 of hepatitis E virus (HEV), recently, has been demonstrated to perform multiple functions besides accessory roles. ORF3 could act as a target for vaccine against HEV infections. The IDR (intrinsically disordered region); IDP (ID protein)/IDPR (ID protein region), plays critical role in various regulatory functions of viruses. The dark proteome of HEV-ORF3 protein including its structure and function was systematically examined by computer predictors to explicate its role in viral pathogenesis and drug resistance beyond its functions as accessory viral protein...
2024: Bioinformation
https://read.qxmd.com/read/38496773/knowledge-attitude-and-factors-associated-with-self-efficacy-in-screening-and-treatment-of-hepatitis-c-among-primary-care-doctors-in-selangor
#10
JOURNAL ARTICLE
Nurulhana Shaikh Mansoor, Farnaza Ariffin, Leny Suzana Suddin, Zati Sabrina Ahmad Zubaidi
INTRODUCTION: Primary care doctors (PCDs) play an increasingly important role in the management of hepatitis C. It is essential for PCDs to have good self-efficacy in screening and treating hepatitis C to achieve good outcomes. This study aimed to determine the knowledge and attitude towards and other factors associated with self-efficacy in screening and treating hepatitis C. METHODS: This cross-sectional study was conducted using an online Google Form. PCDs working at primary healthcare clinics were selected via simple random sampling...
2024: Malaysian Family Physician
https://read.qxmd.com/read/38496629/pkhd1l1-is-required-for-stereocilia-bundle-maintenance-prolonged-hearing-function-and-enhanced-resilience-to-noise-exposure
#11
Olga S Strelkova, Richard T Osgood, Chunjie J Tian, Xinyuan Zhang, Evan Hale, Pedro De-la-Torre, Daniel M Hathaway, Artur A Indzhykulian
Sensory hair cells of the cochlea are essential for hearing, relying on the mechanosensitive stereocilia bundle at their apical pole for their function. Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1) is a stereocilia protein required for normal hearing in mice, and for the formation of the transient stereocilia surface coat, expressed during early postnatal development. While the function of the stereocilia coat remains unclear, growing evidence supports PKHD1L1 as a human deafness gene. In this study we carry out in depth characterization of PKHD1L1 expression in mice during development and adulthood, analyze hair-cell bundle morphology and hearing function in aging PKHD1L1-defficient mouse lines, and assess their susceptibility to noise damage...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38496485/comparative-associations-of-masld-and-mafld-with-the-presence-and-severity-of-coronary-artery-calcification
#12
Min Kyu Kang, Jeong Song, Rohit Loomba, Soo Park, Won Tak, Young Kweon, Yu Lee, Jung Gil Park
We aimed to compare the associations of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) with coronary artery calcification (CAC). Patients who simultaneously underwent ultrasonography to diagnose hepatic steatosis and cardiac computed tomography to detect CAC were included. The presence and severity of CAC were defined with CAC-score thresholds of > 0 and > 300, respectively, and patients were divided into the following groups: no MASLD or MAFLD (reference), MASLD-only, MAFLD-only, and overlapping groups...
March 5, 2024: Research Square
https://read.qxmd.com/read/38496355/ifn-%C3%AE-il-17-il-22-cd4-subset-in-patients-with-hepatitis-c-virus-and-correlation-with-clinical-factor
#13
JOURNAL ARTICLE
Soolmaz Khansalar, Zahra Faghih, Shaghik Barani, Mehdi Kalani, Mohammad Reza Ataollahi, Zeinab Mohammadi, Sepideh Namdari, Kurosh Kalantar
BACKGROUND: CD4+ T cell responses in HCV infection have a crucial role in the immunopathology of hepatitis C virus (HCV) infection. Our aim was to investigate the frequency of Th1, Th17, and Th22 cells in HCV-infected patients and elucidate their role in the progression of the disease. METHODS: Twenty-six HCV-infected patients and 26 healthy individuals were recruited. Peripheral blood mononuclear cells (PBMCs) were stained to separate CD4, IFN-γ, IL-17, and IL-22 producing cells using flow cytometry...
2024: American Journal of Clinical and Experimental Immunology
https://read.qxmd.com/read/38496311/cecropin-a-investigation-of-a-host-defense-peptide-with-multifaceted-immunomodulatory-activity-in-a-chicken-hepatic-cell-culture
#14
JOURNAL ARTICLE
Rege Anna Márton, Csilla Sebők, Máté Mackei, Patrik Tráj, Júlia Vörösházi, Ágnes Kemény, Zsuzsanna Neogrády, Gábor Mátis
INTRODUCTION: Host defense peptides (HDPs) are increasingly referred to as promising candidates for the reduction of the use of conventional antibiotics, thereby combating antibiotic resistance. As HDPs have been described to exert various immunomodulatory effects, cecropin A (CecA) appears to be a potent agent to influence the host inflammatory response. METHODS: In the present study, a chicken primary hepatocyte-non-parenchymal cell co-culture was used to investigate the putative immunomodulatory effects of CecA alone and in inflammatory conditions evoked by polyinosinic-polycytidylic acid (Poly I:C)...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38496200/riedel-s-lobe-and-beaver-tail-variant-a-cadaveric-case-report
#15
Femina Sam, Jenny Jacob, Suganthy Rabi
Variations of the liver in the form of accessory lobes account for about less than 1%. One of the commonest accessory lobes on the right is Riedel's lobe. An occasional anatomical variant of the left lobe is the beaver tail variant. Both variants are reported to be common in females. We hereby report two cases. A 45-year-old female cadaver was noticed to have Riedel's lobe and beaver tail variant. Riedel's lobe appeared to be a tongue-like projection from the right inferior margin of the liver, almost reaching the level of the iliac crest...
February 2024: Curēus
https://read.qxmd.com/read/38496121/role-of-portosystemic-shunt-and-portal-vein-stent-in-managing-portal-hypertension-due-to-hematological-diseases
#16
JOURNAL ARTICLE
Ji Hoon Kim, Suho Kim, Hee-Chul Nam, Chang Wook Kim, Jae-Sung Yoo, Ji Won Han, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Ho-Jong Chun, Sung-Eun Lee, Jung-Suk Oh, Pil Soo Sung
INTRODUCTION: Patients with hematological diseases experience complications related to portal hypertension, including life-threatening complications such as variceal bleeding. METHODS: We analyzed the prognosis of patients with hematological diseases and portal hypertension treated with transjugular intrahepatic portosystemic shunts (TIPS) or portal vein stents. We retrospectively assessed patients with hematological diseases and portal hypertension who had variceal bleeding...
February 2024: Curēus
https://read.qxmd.com/read/38496100/altered-liver-biochemistry-and-mortality-in-patients-hospitalized-with-covid-19
#17
JOURNAL ARTICLE
Felipe A Muñoz Rossi, Diana Marcela Gallo Orjuela, Ana Maria Guaiquil, Camilo Gonzalez, Juanita Salazar Agudelo, Néstor Israel Quinapanta Castro, Angie Osorio, Diana Villegas Valle, Angel Moncayo Castillo, Jose Cabarcas Rua
UNLABELLED: COVID-19 is an illness caused by the SARS-CoV-2 virus, a type of coronavirus initially identified in China in late 2019, emerging as the leading cause of death attributed to a single infectious agent worldwide. The COVID-19 pandemic poses a substantial challenge to global public health in the first quarter of this century. The rapid evolution of the pandemic and its intricate response have hindered the formulation of definitive conclusions, and it may take years to comprehend its long-term effects...
February 2024: Curēus
https://read.qxmd.com/read/38496080/evaluation-of-the-general-population-s-knowledge-concerning-liver-health-a-cross-sectional-study
#18
JOURNAL ARTICLE
Hidar Alibrahim, Haidara Bohsas, Sarya Swed, Khaled Albakri, Yossef H AbdeQadir, Sara Ramadan, Lazaward Kazan, Heba Haj Saleh, Fatema Ali Asgar Tashrifwala, Mohamad Al Ibrahim, Sabine Tayfour, Touka Abo Alsel, Abdullah Alnehlawi, Ubaid Khan, Ashraf N B Boktor, Ibrahim Elbialy, Hekmieh Manad, Reem Rizk Abazid, Wael Hafez
INTRODUCTION: Liver disease is among the leading causes of global mortality and morbidity. Given their substantial impact on public health, raising awareness about liver diseases is paramount for their prevention and effective management. This study aimed to evaluate the knowledge, awareness, attitudes, and behaviors of Syrians regarding liver health, chronic liver disorders, and their associated serious and irreversible complications. METHODS: We conducted a cross-sectional study encompassing the adult Syrian population between August 25 and September 29, 2023, excluding non-Syrians and individuals below the age of 18 years...
February 2024: Curēus
https://read.qxmd.com/read/38495918/graft-versus-leukaemia-immunity-is-retained-following-treatment-with-post-transplant-cyclophosphamide-alone-or-combined-with-tocilizumab-in-humanised-mice
#19
JOURNAL ARTICLE
Chloe Sligar, Ellie Reilly, Peter Cuthbertson, Kara L Vine, Katrina M Bird, Amal Elhage, Stephen I Alexander, Ronald Sluyter, Debbie Watson
OBJECTIVES: Donor haematopoietic stem cell transplantation treats leukaemia by inducing graft-versus-leukaemia (GVL) immunity. However, this benefit is often mitigated by graft-versus-host disease (GVHD), which is reduced by post-transplant cyclophosphamide (PTCy) alone or combined with tocilizumab (TOC) in humanised mice. This study established a preclinical humanised mouse model of GVL and investigated whether PTCy alone or combined with TOC impacts GVL immunity. METHODS: NOD- scid -IL2Rγnull mice were injected with 2 × 107 human peripheral blood mononuclear cells (hPBMCs) on day 0 and with 1 × 106 THP-1 acute myeloid leukaemia cells on day 14...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38495785/associations-between-type-2-diabetes-mellitus-and-chronic-liver-diseases-evidence-from-a-mendelian-ranldomization-study-in-europeans-and-east-asians
#20
JOURNAL ARTICLE
Yue Zhao, Di Li, Hanyu Shi, Wei Liu, Jiaojiao Qiao, Shanfu Wang, Yiwei Geng, Ruiying Liu, Feng Han, Jia Li, Wei Li, Fengyun Wu
OBJECTIVE: Multiple observational studies have demonstrated an association between type 2 diabetes mellitus (T2DM) and chronic liver diseases (CLDs). However, the causality of T2DM on CLDs remained unknown in various ethnic groups. METHODS: We obtained instrumental variables for T2DM and conducted a two-sample mendelian randomization (MR) study to examine the causal effect on nonalcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), viral hepatitis, hepatitis B virus (HBV) infection, and hepatitis C virus (HCV) infection risk in Europeans and East Asians...
2024: Frontiers in Endocrinology
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