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Periodontal Tx Atorvastatin

David R Rosenberg, Catherine X Andrade, Alejandra P Chaparro, Carolina M Inostroza, Valeria Ramirez, Déborah Violant, José Nart
BACKGROUND: The pleiotropic effects of statins, such as immunomodulation and anti-inflammatory effects, may also improve periodontal conditions. The aim of the present study is to assess the effectiveness of a dentifrice medicated with 2% atorvastatin in improving clinical periodontal parameters as a complement to non-surgical periodontal treatment (NSPT). METHODS: A randomized, double-masked clinical trial was performed with two parallel groups: 1) atorvastatin group (NSPT plus medicated 2% atorvastatin dentifrice) and 2) placebo group (NSPT plus placebo dentifrice)...
May 2015: Journal of Periodontology
Raimundo Fernandes de Araújo Júnior, Tatiana Oliveira Souza, Lígia Moreno de Moura, Kerginaldo Paulo Torres, Lélia Batista de Souza, Maria do Socorro Costa Feitosa Alves, Hugo Oliveira Rocha, Aurigena Antunes de Araújo
The aim of this study is to determine the effects of Atorvastatin treatment, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, in periodontal disease. Male Wistar albino rats were randomly divided into five groups of ten rats each: (1) non-ligated treatment (NL), (2) ligature only (L), (3) ligature plus 1 mg/kg Atorvastatin daily for 10 days, (4) ligature plus 5 mg/kg Atorvastatin daily for 10 days, and (5) ligature plus 10 mg/kg Atorvastatin daily for 10 days. Following the treatment course, the periodontal tissue of the animals was analyzed by Measurement of alveolar bone loss, Histopathology and immunohistochemistry to determine of the expression of COX-2, MMP-2, MMP9, and RANKL/RANK/OPG...
2013: PloS One
Sharath Subramanian, Hamed Emami, Esad Vucic, Parmanand Singh, Jayanthi Vijayakumar, Kenneth M Fifer, Achilles Alon, Sudha S Shankar, Michael Farkouh, James H F Rudd, Zahi A Fayad, Thomas E Van Dyke, Ahmed Tawakol
OBJECTIVES: The purpose of this study was to test whether high-dose statin treatment would result in a reduction in periodontal inflammation as assessed by (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT). BACKGROUND: Periodontal disease (PD) is an independent risk factor for atherosclerosis. METHODS: Eighty-three adults with risk factors or with established atherosclerosis and who were not taking high-dose statins were randomized to atorvastatin 80 mg vs...
December 24, 2013: Journal of the American College of Cardiology
P Goes, I M Melo, L M C M Silva, N M B Benevides, N M N Alencar, R A Ribeiro, V Lima
BACKGROUND AND OBJECTIVE: Atorvastatin (ATV) has bone anabolic properties, and alendronate (ALD) is an important antiresorptive drug. This study aimed to evaluate the effects of the combination of ALD and ATV on ligature-induced alveolar bone loss in rats. MATERIAL AND METHODS: Periodontitis was induced by ligature in 78 Wistar rats. Groups of six rats prophylactically received 0.9% saline (SAL), ALD (0.01 or 0.25 mg/kg subcutaneously) or ATV (0.3 or 27 mg/kg by gavage)...
February 2014: Journal of Periodontal Research
Umut Balli, Gonca Cayir Keles, Burcu Ozkan Cetinkaya, Ugur Mercan, Bulent Ayas, Deniz Erdogan
BACKGROUND: The aim of this study is to examine, for the first time, the role of systemic and local atorvastatin application on periodontium using histomorphometric and immunohistochemical analysis during and after experimental periodontitis induction with or without the presence of microbial dental biofilm. METHODS: One hundred ten male Wistar rats were used. Silk ligatures were placed around the cervical area of the mandibular first molars; rats in the healthy control group received no ligatures (n = 10)...
January 2014: Journal of Periodontology
A R Pradeep, Minal Kumari, Nishanth S Rao, Santosh S Martande, Savitha B Naik
BACKGROUND: Atorvastatin (ATV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Recently, statins have shown pleiotropic effects such as anti-inflammation and bone stimulation. The aim of the present study is to investigate the effectiveness of 1.2% ATV as an adjunct to scaling and root planing (SRP) in the treatment of intrabony defects (IBDs). METHODS: Sixty individuals were randomized into two treatment groups: SRP plus 1...
July 2013: Journal of Periodontology
Martha Eugenia Fajardo, Miriam Lucía Rocha, Francisco Javier Sánchez-Marin, Emanuel Jaime Espinosa-Chávez
AIM: We studied the effect of atorvastatin (ATV) treatment on bone loss prevention in subjects with chronic periodontitis. MATERIAL AND METHODS: In this controlled double-blind study, 38 subjects with chronic periodontitis were randomized into two groups, paired by age to receive ATV (20 mg) or placebo daily for 3 months. Periodontal mechanical treatment was carried out in both groups at baseline. Clinical and radiographic parameters and bone turnover markers were assessed at baseline and at 3 months...
November 2010: Journal of Clinical Periodontology
Otso Lindy, Kimmo Suomalainen, Marja Mäkelä, Seppo Lindy
BACKGROUND: Inflammatory processes are considered to participate in the development of cardiovascular disease (CVD). Statins have been used successfully in the prevention and treatment of coronary heart disease. Chronic periodontitis has been suggested to contribute to CVD. The aim of this study was to examine the association of statin use and clinical markers of chronic periodontitis. METHODS: Periodontal probing pocket depth (PPD) values were collected from dental records of 100 consecutive adult patients referred to a university dental clinic for treatment of advanced chronic periodontitis...
2008: BMC Oral Health
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