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https://www.readbyqxmd.com/read/29602286/comparison-of-th17-cells-mediated-immunological-response-among-asthmatic-children-with-or-without-allergic-rhinitis
#1
Miao Qing, Liu Yongge, Xu Wei, Wang Yan, Li Zhen, Ren Yixin, Guan Hui, Xiang Li
OBJECTIVE: To investigate whether there were differences in Th17 cells mediated immunological responses among asthmatics with or without allergic rhinitis. METHODS: A case-control comparison was conducted in a cohort of 67 children with asthma (AS), 50 children with allergic rhinitis (AR), 52 children with both AS and AR (ASR), 25 infectious rhinitis (IR), and 55 healthy controls (HC). The percentages of circulating Th17 cells were determined by flow cytometry. The Th2- and Th17-related cytokines in plasma and culture supernatants were measured by enzyme-linked immunosorbent assay...
March 31, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29600943/silent-arterial-inflammation-during-the-apparent-remission-state-of-takayasu-s-arteritis-what-do-cytokines-tell-us
#2
Bruna Savioli, Bruno Ramos Salu, Marlon Vilela de Brito, Maria Luiza Vilela Oliva, Alexandre W S de Souza
OBJECTIVES: To evaluate serum cytokines as biomarkers of smoldering disease activity in patients with Takayasu's arteritis (TAK) in remission. METHODS: Thirty-four TAK patients with stable disease during the last 6 months and 22 healthy controls (HC) were included in a cross-sectional study. Serum levels of pro-inflammatory, anti-inflammatory, Th1, Th2, Th9, Th17 and Th22 cytokines were measured by the multiplex technique. RESULTS: No significant differences regarding serum cytokine levels were found between TAK patients and HC...
March 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29572351/interleukin-25-il-25-has-a-protective-role-in-atherosclerosis-development-in-the-aortic-arch-in-mice
#3
Polyxeni T Mantani, Pontus Dunér, Eva Bengtsson, Irena Ljungcrantz, Lena Sundius, Fong To, Jan Nilsson, Harry Björkbacka, Gunilla Nordin Fredrikson
Atherosclerosis is a chronic inflammatory disease characterized by the entrapment of apolipoprotein B-containing lipoproteins in the arterial intima, leading to local inflammation. T helper (Th) cell 1-mediated immune responses have been associated with atherosclerosis, and the cytokine interleukin-25 (IL-25 or IL-17E) has been reported to potentially regulate Th1 cell- and Th17 cell-related immune responses. In this study, we evaluated the effects of complete IL-25 deficiency or of a temporal IL-25 blockade on atherosclerosis development in apolipoprotein E-deficient ( Apoe -/- ) mice...
May 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29548809/expression-and-location-of-il-17a-e-f-and-their-receptors-in-colorectal-adenocarcinoma-comparison-with-benign-intestinal-disease
#4
Yanbo Liu, Xuemei Sun, Xiaohui Zhao, Liping An, Zhuxing Wang, Jing Jiang, Weigao Shen, Xueliang Yang, Ying Sun
The research aimed to investigate secretion, expression and location of IL-17 relative ligands, IL-17 relative receptors, infiltrating inflammatory cells and parenchymal structural cells in colorectal cancer (CRC) compared with ulcerative colitis (UC) and benign hyperplastic polyp. 29 human intestinal tissues with CRC, 17 with UC and 7 with polyp were stained using immunohistochemistry to evaluate immunoreactivity for IL-17 family relative ligands including IL-17A, E, F and their respective relative receptors such as IL-17RA, IL-17RB and IL-17RC...
April 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29399438/type-2-cytokine-responses-regulating-immunity-to-helminth-parasites-and-allergic-inflammation
#5
Everett K Henry, Juan M Inclan-Rico, Mark C Siracusa
Purpose of Review: It is well established that T helper type 2 (TH 2) immune responses are necessary to provide protection against helminth parasites but also to promote the detrimental inflammation associated with allergies and asthma. Given the importance of type 2 immunity and inflammation, many studies have focused on better understanding the factors that regulate TH 2 cell development and activation. As a result, significant progress has been made in understanding the signaling pathways and molecular events necessary to promote TH 2 cell polarization...
December 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/29205464/interleukin-17-family-cytokines-in-protective-immunity-against-infections-role-of-hematopoietic-cell-derived-and-non-hematopoietic-cell-derived-interleukin-17s
#6
REVIEW
Goro Matsuzaki, Masayuki Umemura
Interleukin-17 family cytokines, consisting of six members, participate in immune response in infections and autoimmune and inflammatory diseases. The prototype cytokine of the family, IL-17A, was originally identified from CD4+ T cells which are now termed Th17 cells. Later, IL-17A-producing cells were expanded to include various hematopoietic cells, namely CD8+ T cells (Tc17), invariant NKT cells, γδ T cells, non-T non-B lymphocytes (termed type 3 innate lymphoid cells) and neutrophils. Some IL-17 family cytokines other than IL-17A are also expressed by CD4+ T cells: IL-17E by Th2 cells and IL-17F by Th17 cells...
January 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/28969940/immune-response-of-th17-associated-cytokines-by-peripheral-blood-mononuclear-cells-from-patients-with-chronic-hepatitis-c-virus-infection
#7
Milena S Cabral, Taciana P S Santos, Priscila L Santos, Maria Isabel Schinoni, Isabela S Oliveira, Ariana B Pereira, Ajax M Atta, Maria Luiza B Sousa-Atta
Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with interferon-α plus ribavirin with or without HCV protease inhibitors, and patients who were nonresponders to HCV therapy. PBMCs were stimulated with HCV core and nonstructural antigens, and the production of Th17-associated cytokines was measured with a Milliplex MAP immunoassay...
February 2018: Cytokine
https://www.readbyqxmd.com/read/28675899/serum-anticytokine-autoantibody-levels-are-not-increased-in-hidradenitis-suppurativa-a-case-control-pilot-study
#8
Peter Theut Riis, Jakob Hjorth von Stemann, Rune Kjærsgaard Andersen, Morten Bagge Hansen, Gregor B E Jemec
BACKGROUND: Hidradenitis suppurativa is a skin disease of recurrent episodes of inflammatory nodules, abscesses, and scarring of the intertriginous regions, e.g. the axillae and groin. A dysregulated immune response to one or more unknown antigens in hidradenitis suppurativa has been suggested. One hypothetical element of this dysregulation may be the functionality of the cytokines. This study examines the serum level of anticytokine autoantibodies for interleukin (IL)-1α, IL-6, IL-10, IL-17A, IL-17E, IL-17F, and interferon-α...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28658555/il-25-in-allergic-inflammation
#9
REVIEW
Miao Xu, Chen Dong
IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer. This review summarizes the literature on IL-25 and discusses the unsolved questions...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28489721/tear-cytokine-levels-in-contact-lens-wearers-with-acanthamoeba-keratitis
#10
Nicole Carnt, Vicente M Montanez, Grazyna Galatowicz, Neyme Veli, Virginia Calder
PURPOSE: To determine differences in key tear film cytokines between mild and severe cases of acanthamoeba keratitis (AK) and control contact lens (CL) wearers. METHODS: This was a prospective study of CL wearers with AK attending Moorfields Eye Hospital and control CL wearers from the Institute of Optometry, London. Basal tear specimens were collected by 10-μL capillary tubes (BLAUBRAND intraMark, Wertheim, Germany), and tear protein levels were measured with a multiplex magnetic bead array (Luminex 100; Luminex Corporation, Austin, TX) for cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17A, IL-17E, IL-17F, IL-22, and interferon gamma and with enzyme-linked immunosorbent assay (Abcam, Cambridge, United Kingdom) for CXCL2...
July 2017: Cornea
https://www.readbyqxmd.com/read/28352347/one-mechanism-of-glucocorticoid-action-in-asthma-may-involve-the-inhibition-of-il-25-expression
#11
Wei Lu, Chao Lu, Chengming Zhang, Chenghao Zhang
While the mechanism of action of classic cytokines in asthma has received increased attention from researchers, certain non-classical cytokines, such as IL-25, also participate in this mechanism. The present study was performed to investigate the changes in IL-25 (IL-17E) mRNA and protein in bronchial asthma and to further characterize the mechanism underlying the action of glucocorticoids in asthma. A total of 96 specific pathogen-free BALB/c male mice were randomly divided into three normal groups (after the first allergization, after the second allergization and after excitation), three asthma groups (with the same three subgroups), a dexamethasone group and a budesonide group (n=12/group)...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28099429/vitamin-d-insufficiency-in-neonatal-hypoxic-ischemic-encephalopathy
#12
Danielle W Lowe, Bruce W Hollis, Carol L Wagner, Thomas Bass, David A Kaufman, Michael J Horgan, Laurence M Givelichian, Koravangatta Sankaran, Jerome Y Yager, Lakshmi D Katikaneni, Don Wiest, Dorothea Jenkins
BACKGROUND: Vitamin D has neuroprotective and immunomodulatory properties, and deficiency is associated with worse stroke outcomes. Little is known about effects of hypoxia-ischemia or hypothermia treatment on vitamin D status in neonates with hypoxic-ischemic encephalopathy (HIE). We hypothesized vitamin D metabolism would be dysregulated in neonatal HIE altering specific cytokines involved in Th17 activation, which might be mitigated by hypothermia. METHODS: We analyzed short-term relationships between 25(OH) and 1,25(OH)2 vitamin D, vitamin D binding protein, and cytokines related to Th17 function in serum samples from a multicenter randomized controlled trial of hypothermia 33 (°)C for 48 h after HIE birth vs...
July 2017: Pediatric Research
https://www.readbyqxmd.com/read/27979026/il-17rb-granulocytes-are-associated-with-airflow-obstruction-in-asthma
#13
Lin Li, Nicholas W Lukacs, Matthew A Schaller, Bryan Petersen, Alan P Baptist
BACKGROUND: Interleukin (IL)-25 (IL-17E) is a proinflammatory cytokine that plays an important role in the T-helper type 2 cell pathway. The effects of IL-25 are mediated by its specific receptor, IL-17RB. Previous studies have defined an IL-17RB+ granulocyte population known as type 2 myeloid (T2M) cells that express T-helper type 2 cell cytokines. The correlation of IL-17RB+ granulocytes, T2M cells, and asthma parameters is unknown. OBJECTIVE: To investigate the relation of IL-17RB+ granulocytes (and its subset, T2M cells) in patients with asthma with clinical parameters including spirometric values and the Asthma Control Test (ACT)...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27930337/genetic-immunological-and-clinical-features-of-patients-with-bacterial-and-fungal-infections-due-to-inherited-il-17ra-deficiency
#14
Romain Lévy, Satoshi Okada, Vivien Béziat, Kunihiko Moriya, Caini Liu, Louis Yi Ann Chai, Mélanie Migaud, Fabian Hauck, Amein Al Ali, Cyril Cyrus, Chittibabu Vatte, Turkan Patiroglu, Ekrem Unal, Marie Ferneiny, Nobuyuki Hyakuna, Serdar Nepesov, Matias Oleastro, Aydan Ikinciogullari, Figen Dogu, Takaki Asano, Osamu Ohara, Ling Yun, Erika Della Mina, Didier Bronnimann, Yuval Itan, Florian Gothe, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Natalia Tahuil, Caner Aytekin, Aicha Salhi, Saleh Al Muhsen, Masao Kobayashi, Julie Toubiana, Laurent Abel, Xiaoxia Li, Yildiz Camcioglu, Fatih Celmeli, Christoph Klein, Suzan A AlKhater, Jean-Laurent Casanova, Anne Puel
Chronic mucocutaneous candidiasis (CMC) is defined as recurrent or persistent infection of the skin, nails, and/or mucosae with commensal Candida species. The first genetic etiology of isolated CMC-autosomal recessive (AR) IL-17 receptor A (IL-17RA) deficiency-was reported in 2011, in a single patient. We report here 21 patients with complete AR IL-17RA deficiency, including this first patient. Each patient is homozygous for 1 of 12 different IL-17RA alleles, 8 of which create a premature stop codon upstream from the transmembrane domain and have been predicted and/or shown to prevent expression of the receptor on the surface of circulating leukocytes and dermal fibroblasts...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909985/il-25-blockade-inhibits-metastasis-in-breast-cancer
#15
Zhujun Jiang, Jingtao Chen, Xuemei Du, Hang Cheng, Xiaohu Wang, Chen Dong
Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was expressed by tumor-infiltrating CD4(+) T cells and macrophages. An IL-25 neutralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung...
March 2017: Protein & Cell
https://www.readbyqxmd.com/read/27871325/impact-of-placental-plasmodium-falciparum-malaria-infection-on-the-cameroonian-maternal-and-neonate-s-plasma-levels-of-some-cytokines-known-to-regulate-t-cells-differentiation-and-function
#16
Jean Claude Djontu, Stalone Siewe Siewe, Yolande Delphine Mpeke Edene, Benderli Christine Nana, Edwige Vanessa Chomga Foko, Jude Daiga Bigoga, Rose F G Leke, Rosette Megnekou
BACKGROUND: The impact of placental malaria (PM) infection on the expression profile of some cytokines known to regulate T cell differentiation and function and their influence on birth weight remain unclear. Moreover, there are no reports showing the relationship between PM and IL-27 or IL-28A. This study therefore sought to investigate whether placental P. falciparum infection alters the expression profile of the cytokines IL-28A, IL-27, IL-17E and IL-6 in mothers and their new born...
November 21, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27716046/immune-analysis-of-expression-of-il-17-relative-ligands-and-their-receptors-in-bladder-cancer-comparison-with-polyp-and-cystitis
#17
COMPARATIVE STUDY
Yanbo Liu, Wanguo Yang, Lijing Zhao, Zuowen Liang, Weigao Shen, Qinlong Hou, Zhenjiang Wang, Jing Jiang, Sun Ying
BACKGROUND: Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign prostatic hyperplasia (BPH) and prostate cancer (Pca) while IL-17E interacting with IL-17RB might have an anti-tumor effect. RESULTS: Using imunohistochemistry, we systemically compared immunoreactivity of ligands (IL-17A, E and F) and receptors (IL-17RA, IL-17RB and IL-17RC) of IL-17 family, infiltration of inflammatory cells and changes of structural cells (fibroblast cells, smooth muscle and vascular endothelial cells) in sections of bladder tissues from subjects with bladder cancer, cystitis and bladder polyp...
October 3, 2016: BMC Immunology
https://www.readbyqxmd.com/read/27594509/a-heterodimeric-cytokine-consisting-of-il-17a-and-il-17f-promotes-migration-and-capillary-like-tube-formation-of-human-vascular-endothelial-cells
#18
Muneo Numasaki, Hiroki Tsukamoto, Yoshihisa Tomioka, Yasuhiko Nishioka, Takashi Ohrui
The interleukin (IL)-17 family, consisting of six homodimeric cytokines IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, mediates a variety of biological activities including regulation of chemokine secretion and angiogenesis. Among the IL-17 family members, IL-17A and IL-17E/IL-25 are angiogenesis stimulators, while IL-17B and IL-17F are angiogenesis inhibitors. Recently, IL-17A/F heterodimer, comprised of the IL-17A and IL-17F subunits, was found as another member of the IL-17 cytokine family. However, to date, it has been unknown whether IL-17A/F has biological actions to affect the angiogenesis-related vascular endothelial functions...
September 2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27591988/il17a-and-il17f-gene-polymorphism-association-with-psoriasis-risk-and-response-to-treatment-in-a-polish-population
#19
Monika Białecka, Roksana Ostasz, Mateusz Kurzawski, Adam Klimowicz, Honorata Fabiańczyk, Piotr Bojko, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzyńska, Marek Droździk
BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27589729/targeting-the-tumor-microenvironment-the-protumor-effects-of-il-17-related-to-cancer-type
#20
REVIEW
Joseph Fabre, Jerome Giustiniani, Christian Garbar, Frank Antonicelli, Yacine Merrouche, Armand Bensussan, Martine Bagot, Reem Al-Dacak
The inflammatory process contributes to immune tolerance as well as to tumor progression and metastasis. By releasing extracellular signals, cancerous cells constantly shape their surrounding microenvironment through their interactions with infiltrating immune cells, stromal cells and components of extracellular matrix. Recently, the pro-inflammatory interleukin 17 (IL-17)-producing T helper lymphocytes, the Th17 cells, and the IL-17/IL-17 receptor (IL-17R) axis gained special attention. The IL-17 family comprises at least six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F...
August 30, 2016: International Journal of Molecular Sciences
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