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Celiac Disease

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https://www.readbyqxmd.com/read/28530848/splanchnic-thoracoabdominal-and-cerebral-blood-flow-volumes-in-healthy-children-and-young-adults-in-fasting-and-postprandial-states-determining-reference-ranges-by-using-phase-contrast-mr-imaging
#1
Prakash Muthusami, Shi-Joon Yoo, Rajiv Chaturvedi, Navjot Gill, Jonathan Windram, Daryl Schantz, Milan Prsa, Pablo Caro-Dominguez, Mike Seed, Lars Grosse-Wortmann, Simon C Ling, Govind B Chavhan
Purpose To estimate reference ranges for blood flow volume (BFV) in major splanchnic, thoracoabdominal, and neck vessels by using phase-contrast magnetic resonance (MR) imaging in children and young adults in fasting and postprandial states. Materials and Methods In this institutional research ethics board-approved prospective study, healthy volunteers underwent phase-contrast MR imaging in a fasting state and again after a standardized meal. BFV values were reported as medians and ranges, and postmeal to premeal BFV ratios were calculated...
May 22, 2017: Radiology
https://www.readbyqxmd.com/read/28526528/gluten-degrading-bacteria-are-present-in-the-human-small-intestine-of-healthy-volunteers-and-celiac-patients
#2
Alexandra R Herrán, Jénifer Pérez-Andrés, Alberto Caminero, Esther Nistal, Santiago Vivas, José María Ruiz de Morales, Javier Casqueiro
Gluten is the only known environmental factor that triggers celiac disease. Several studies have described an imbalance between the intestinal microbiota of different individuals based on diagnoses. Moreover, recent studies have suggested that human bacteria may play an important role in gluten hydrolysis. However, there has been no research focusing on the small intestine. This study aimed to characterize the adult small intestine microbiota possibly implicated in gluten hydrolysis. Duodenal biopsies from different diagnosed individuals were cultured in a gluten-containing medium, and the grown microbiota was analyzed by culture dependent/independent methods...
May 16, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28514313/clinical-and-biological-correlations-in-celiac-disease-in-children-the-prospective-single-experience-of-a-romanian-tertiary-center-a-case-control-study-strobe-compliant-study
#3
Cristina Oana Marginean, Lorena Elena Meliţ, Roxana-Cristina Mareş, Maria Oana Mărginean, Septimiu Voidăzan, Minodora Dobreanu
Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also to evaluate the clinical and laboratory characteristics of patients admitted with the suspicion of celiac disease (CD)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28514243/celiac-disease-symptom-resolution-effectiveness-of-the-gluten-free-diet
#4
Naire Sansotta, Stefano Guandalini, Karine Amirikian, Hilary Jericho
OBJECTIVE: To evaluate the efficacy of the gluten free diet (GFD) on gastrointestinal and extra-intestinal symptom resolution and identify predictors for persistence of symptoms in all celiac patients at the University of Chicago. METHODS: We conducted a retrospective chart review from 2002 to 2015. Gastrointestinal (GI) symptoms included: abdominal pain, bloating, constipation, diarrhea, failure to thrive/weight loss, nausea, reflux and vomiting. Extra-intestinal (EI) symptoms included: abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis, alopecia, fatigue, headache, anemia, stomatitis, myalgia, psychiatric disorders, rashes, seizures, neuropathy, short stature, delayed puberty, osteoporosis, and infertility...
May 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28508029/a-b-cell-gene-signature-correlates-with-the-extent-of-gluten-induced-intestinal-injury-in-celiac-disease
#5
Mitchell E Garber, Alok Saldanha, Joel S Parker, Wendell D Jones, Katri Kaukinen, Kaija Laurila, Marja-Leena Lähdeaho, Purvesh Khatri, Chaitan Khosla, Daniel C Adelman, Markku Mäki
BACKGROUND & AIMS: Celiac disease (CeD) provides an opportunity to study autoimmunity and the transition in immune cells as dietary gluten induces small intestinal lesions. METHODS: Seventy-three celiac disease patients on a long-term, gluten-free diet ingested a known amount of gluten daily for 6 weeks. A peripheral blood sample and intestinal biopsy specimens were taken before and 6 weeks after initiating the gluten challenge. Biopsy results were reported on a continuous numeric scale that measured the villus-height-to-crypt-depth ratio to quantify gluten-induced intestinal injury...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28507749/splenic-volume-differentiates-complicated-and-non-complicated-celiac-disease
#6
Tom van Gils, Petula Nijeboer, Jan Hein Tm van Waesberghe, Veerle Mh Coupé, Kiki Janssen, Jessy A Zegers, Shaikh A Nurmohamed, Georg Kraal, Sabine Ci Jiskoot, Gerd Bouma, Chris Jj Mulder
BACKGROUND: Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). OBJECTIVE: The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. METHODS: The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28507424/migraine-celiac-disease-and-intestinal-microbiota
#7
COMMENT
Hakim Rahmoune, Nada Boutrid
Investigators from four European tertiary care hospitals (in Paris, France; Milan, Udine and Perugia, Italy) performed a case-control study of children and adolescents aged 6 to 17 years diagnosed with primary headaches in the emergency department by a pediatric neurologist using the validated ICHD-3 criteria.
February 2017: Pediatric neurology briefs
https://www.readbyqxmd.com/read/28507006/perspective-gluten-free-products-for-patients-with-celiac-disease-should-not-contain-trace-levels
#8
Peter Makovicky, Pavol Makovicky, Iulia Lupan, Gabriel Samasca, Genel Sur, Hugh James Freeman
No abstract text is available yet for this article.
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28506952/retrospective-evaluation-of-pregnant-women-with-celiac-disease
#9
Kemal Beksaç, Gökçen Örgül, Murat Çağan, Ergun Karaağaoğlu, Serap Arslan, Mehmet Sinan Beksaç
OBJECTIVE: To show celiac disease (CD) and its poor pregnancy outcome relationship, and to demonstrate the importance of a gluten-free diet together with low-dose low-molecular-weight heparin (LMWH) and low-dose corticosteroid (LDC) in the management of pregnancies with CD. MATERIAL AND METHODS: This study consisted of 2 groups of patients. Six patients with CD (control group) on a gluten-free diet were monitored during their first pregnancies within the framework of antenatal care program and their pregnancy outcomes were compared with eight poorly-treated pregnant patients with CD (study group) who were referred from other medical institutions...
March 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28505210/whole-exome-sequencing-of-a-consanguineous-family-identifies-the-possible-modifying-effect-of-a-globally-rare-ak5-allelic-variant-in-celiac-disease-development-among-saudi-patients
#10
Jumana Yousuf Al-Aama, Noor Ahmad Shaik, Babajan Banaganapalli, Mohammed A Salama, Omran Rashidi, Ahmed N Sahly, Mohammed O Mohsen, Harbi A Shawoosh, Hebah Ahmad Shalabi, Mohammad Al Edreesi, Sameer E Alharthi, Jun Wang, Ramu Elango, Omar I Saadah
Celiac disease (CD), a multi-factorial auto-inflammatory disease of the small intestine, is known to occur in both sporadic and familial forms. Together HLA and Non-HLA genes can explain up to 50% of CD's heritability. In order to discover the missing heritability due to rare variants, we have exome sequenced a consanguineous Saudi family presenting CD in an autosomal recessive (AR) pattern. We have identified a rare homozygous insertion c.1683_1684insATT, in the conserved coding region of AK5 gene that showed classical AR model segregation in this family...
2017: PloS One
https://www.readbyqxmd.com/read/28502679/the-association-between-semaphorin-3a-levels-and-gluten-free-diet-in-patients-with-celiac-disease
#11
Aharon Kessel, Chen Lin, Zahava Vadasz, Regina Peri, Nasren Eiza, Drora Berkowitz
Celiac disease (CD) is an inflammatory disease affecting the small intestine. We aim to assess serum level and expression of semaphorin 3A (Sema3A) on T regulatory (Treg) cells in CD patients. Twenty-six newly diagnosed celiac patients, 13 celiac patients on a gluten-free diet and 16 healthy controls included in the study. Sema3A protein level in the serum of celiac patients was significantly higher compared to healthy group (7.17±1.8ng/ml vs. 5.67±1.5ng/ml, p=0.012). Sema3A expression on Treg cells was statistically lower in celiac patients compared to healthy subjects (p=0...
May 11, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28502438/celiac-disease-and-nonceliac-gluten-sensitivity
#12
REVIEW
Runa D Watkins, Shamila Zawahir
Gluten-related disorders include celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity. CD is an autoimmune enteropathy caused by damage to small intestinal mucosa when gluten is ingested in genetically susceptible individuals. Currently, the only available treatment of CD is gluten-free diet. Several potential treatments are being researched. Wheat allergy is a hypersensitivity reaction caused by IgE-mediated and/or non-IgE-mediated immune response, and can involve the gastrointestinal tract, skin, or respiratory tract...
June 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28500039/selected-probiotic-lactobacilli-have-the-capacity-to-hydrolyze-gluten-peptides-during-simulated-gastro-intestinal-digestion
#13
Ruggiero Francavilla, Maria De Angelis, Carlo Giuseppe Rizzello, Noemi Cavallo, Fabio Dal Bello, Marco Gobbetti
The aim of this study was to demonstrate the capacity of probiotic lactobacilli to hydrolyze immunogenic gluten peptides. Eighteen commercial strains of probiotic lactobacilli with highly variable peptidase activity (i.e., aminopeptidase N, iminopeptidase, prolyl endopeptidyl peptidase, tripeptidase, prolidase, prolinase and dipeptidase), including towards Pro-rich peptides, were tested in this study. Ten probiotic strains were selected based on their specific enzyme activity. When pooled, these ten strains provide the peptidase portfolio that is required to completely degrade the immunogenic gluten peptides involved in celiac disease (CD)...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28499697/assessment-of-dietary-compliance-in-celiac-children-using-a-standardized-dietary-interview
#14
Margaretha M S Wessels, Marije Te Lintelo, Sabine L Vriezinga, Hein Putter, Erica G Hopman, M Luisa Mearin
BACKGROUND & AIMS: Compliance to a gluten free diet (GFD) in celiac disease (CD) is ideally assessed by dietary interviews, albeit time-consuming. Short dietary questionnaires have been developed for adults but not for children. Primary aim was to compare GFD compliance in celiac children, measured by a short dietary questionnaire against a dietary interview. Secondary aims were correlation between both questionnaires and celiac antibodies and identifying variables predicting noncompliance...
April 17, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28496327/anorexia-nervosa-of-the-restrictive-type-and-celiac-disease-in-adolescence
#15
Renata Nacinovich, Lucio Tremolizzo, Fabiola Corbetta, Elisa Conti, Francesca Neri, Monica Bomba
BACKGROUND: Anorexia nervosa (AN) is usually present in adolescence with symptoms partially overlapping celiac disease (CD), but the relationship between these two conditions has received little attention in the literature. The aim of this work was to explore this relationship, considering if CD could be associated with specific baseline AN-related clinical features. METHODS: In this retrospective study, 82 adolescent female out- and inpatients with AN of the restrictive type (ANr), according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria, were recruited...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28491884/association-of-autoimmune-hepatitis-and-celiac-disease-role-of-gluten-free-diet-in-reversing-liver-dysfunction
#16
Umair Iqbal, Ahmad Chaudhary, Muhammad Arsalan Karim, Muhammad Arsalan Siddiqui, Hafsa Anwar, Nancy Merrell
Autoimmune hepatitis (AIH) is a chronic inflammation of liver with unclear etiology. It is frequently associated other autoimmune diseases, and its association with celiac disease (CD) is well established. In this article, we describe the case of a 50-year-old male with long-standing AIH taking azathioprine for 10 years, evaluated for flares in transaminases. Despite adding high-dose corticosteroids, his transaminases and bilirubin remained high. Serology for CD was ordered, which revealed elevated tissue transglutaminase antibody IgG and endomysial IgA, which was further confirmed by endoscopic biopsy...
April 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28489931/cortical-involvement-in-celiac-disease-before-and-after-long-term-gluten-free-diet-a-transcranial-magnetic-stimulation-study
#17
Manuela Pennisi, Giuseppe Lanza, Mariagiovanna Cantone, Riccardo Ricceri, Raffaele Ferri, Carmela Cinzia D'Agate, Giovanni Pennisi, Vincenzo Di Lazzaro, Rita Bella
OBJECTIVE: Transcranial Magnetic Stimulation in de novo patients with Celiac Disease previously revealed an imbalance in the excitability of cortical facilitatory and inhibitory circuits. After a median period of 16 months of gluten-free diet, a global increase of cortical excitability was reported, suggesting a glutamate-mediated compensation for disease progression. We have now evaluated cross-sectionally the changes of cortical excitability to TMS after a much longer gluten-free diet...
2017: PloS One
https://www.readbyqxmd.com/read/28489675/no-need-for-routine-endoscopy-in-children-with-celiac-disease-on-a-gluten-free-diet
#18
Sibylle Koletzko, Renata Auricchio, Jernej Dolinsek, Peter Gillett, Ilma Korponay-Szabo, Kalle Kurppa, Luisa Mearin, Markkku Mäki, Alina Popp, Carmen Ribes, Raanan Shamir, Ketil Stordal, Riccardo Troncone, Katharina Werkstetter, Margreet Wessels, Klaus-Peter Zimmer, Steffen Husby
No abstract text is available yet for this article.
May 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28489059/the-impact-of-diet-wheat-source-on-the-onset-of-type-1-diabetes-mellitus-lessons-learned-from-the-non-obese-diabetic-nod-mouse-model
#19
Jonathan Gorelick, Ludmila Yarmolinsky, Arie Budovsky, Boris Khalfin, Joshua D Klein, Yosi Pinchasov, Maxim A Bushuev, Tatiana Rudchenko, Shimon Ben-Shabat
Nutrition, especially wheat consumption, is a major factor involved in the onset of type 1 diabetes (T1D) and other autoimmune diseases such as celiac. While modern wheat cultivars possess similar gliadin proteins associated with the onset of celiac disease and T1D, alternative dietary wheat sources from Israeli landraces and native ancestral species may be lacking the epitopes linked with T1D, potentially reducing the incidence of T1D. The Non-Obese Diabetic (NOD) mouse model was used to monitor the effects of dietary wheat sources on the onset and development of T1D...
May 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28487600/dietary-compliance-in-celiac-disease
#20
EDITORIAL
Hugh James Freeman
Celiac disease is an immune-mediated disorder that causes severe architectural disturbance in the small intestinal mucosa of genetically-predisposed individuals. Impaired absorption of multiple nutrients results and diarrhea and weight loss develop. Evidence has accumulated that a strict gluten-free diet can result in resolution of diarrhea, weight gain and normalization of nutrient malabsorption. In addition, histopathological changes also normalize, but this histopathological response appears to be time-dependent, sex-dependent and age-dependent...
April 21, 2017: World Journal of Gastroenterology: WJG
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