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Graves disease

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https://www.readbyqxmd.com/read/28529524/antithyroid-drug-therapy-for-graves-disease-and-implications-for-recurrence
#1
REVIEW
Jia Liu, Jing Fu, Yuan Xu, Guang Wang
Graves' disease (GD) is the most common cause of hyperthyroidism worldwide. Current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine, and thyroidectomy. ATD treatment is generally well accepted by patients and clinicians due to some advantages including normalizing thyroid function in a short time, hardly causing hypothyroidism, and ameliorating immune disorder while avoiding radiation exposure and invasive procedures. However, the relatively high recurrence rate is a major concern for ATD treatment, which is associated with multiple influencing factors like clinical characteristics, treatment strategies, and genetic and environmental factors...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28521825/association-of-4p14-and-6q27-variation-with-graves-disease-a-case-control-study-and-a-meta-analysis-of-available-evidence
#2
Fa-Mei Li, Lin Liu, Li-Nan Pang, Min Shen, Hong-Wen Lu, Xiao-Hong Zhang, Xun Chu, Zhen-Ju Song
BACKGROUND: The etiology of the Graves' disease (GD) is largely unknown. However, genetic factors are believed to play a major role. A recent genome-wide association study in a Han Chinese sample collection revealed two new Graves' disease (GD) risk loci within chromosome band 4p14 and 6q27. In this study, we aimed to investigate these associations with Weifang Han Chinese population of Shandong province and perform a meta-analysis of associations with GD. METHODS: A case-control study was conducted to investigate association of variation within 4p14 and 6q27 to GD susceptibility in Weifang Han Chinese population of Shandong province...
May 18, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28515387/functional-polymorphisms-affecting-th1-differentiation-are-associated-with-the-severity-of-autoimmune-thyroid-diseases
#3
Naoya Inoue, Mikio Watanabe, Azusa Nakaguchi, Daishi Ueda, Hayaka Kawaguti, Yoh Hidaka, Yoshinori Iwatani
The prognosis for autoimmune thyroid diseases (AITDs), such as Hashimoto's disease (HD) and Graves' disease (GD), varies among patients. Interleukin (IL)-12 and IL-18 also induce Th1 differentiation, and SOCS1 (Suppressor of cytokine signaling 1) and TIM-3 (T cell immunoglobulin and mucin domain-3) are known to be negative regulators of Th1 cells. To clarify the association of functional polymorphisms in the IL12, IL12Rβ1, IL18, SOCS1 and TIM3 genes with the intractability and severity of autoimmune thyroid disease (AITD), we genotyped these polymorphisms in 151 GD patients, including 61 patients with intractable GD and 51 patients with GD in remission, in 140 HD patients, including 59 patients with severe HD and 55 patients with mild HD, and in 74 healthy controls...
May 16, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28502931/graves-disease-in-pediatric-and-elderly-patients-with-22q11-2-deletion-syndrome
#4
Yoko Ueda, Shinsuke Uraki, Hidefumi Inaba, Sakiko Nakashima, Hiroyuki Ariyasu, Hiroshi Iwakura, Takayuki Ota, Hiroto Furuta, Masahiro Nishi, Takashi Akamizu
22q11.2 Deletion Syndrome (22qDS) is often complicated by autoimmune diseases. To clarify the causal relationship, we examined the lymphocyte subset distribution and the human leucocyte antigen (HLA) in two female patients (one child and an elderly) with Graves' disease (GD) and 22qDS. Thymus dysgenesis might have contributed to the T-cell imbalance and the lack of negative selection in both cases. Notably, HLA-DR14, a known risk factor for GD in Japanese individuals and the decreased regulatory T-cell numbers that were seen in the pediatric case, may affect the early onset of GD...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28500376/the-ptpn22-r263q-polymorphism-confers-protection-against-systemic-lupus-erythematosus-and-rheumatoid-arthritis-while-ptpn22-r620w-confers-susceptibility-to-graves-disease-in-a-mexican-population
#5
Daniela Josabeth López-Cano, Daniel Cadena-Sandoval, Olga Beltrán-Ramírez, Rosa Elda Barbosa-Cobos, Fausto Sánchez-Muñoz, Luis Manuel Amezcua-Guerra, Yaneli Juárez-Vicuña, María Concepción Aguilera-Cartas, José Moreno, Jesús Bautista-Olvera, Guillermo Valencia-Pacheco, Ricardo F López-Villanueva, Julian Ramírez-Bello
OBJECTIVE: The functional PTPN22 R620W polymorphism (rs2476601) is clearly associated with susceptibility to several autoimmune diseases (ADs). However, the PTPN22 R263Q polymorphism (rs33996649) has been scarcely explored in different ADs. Here we aimed to examine the associations of the PTPN22 R620W and R263Q polymorphisms with susceptibility to or protection against rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD) among Mexican patients. METHODS: We conducted a case-control study including 876 patients (405 with SLE, 388 with RA, and 83 with GD) and 336 healthy control individuals...
May 12, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28497925/increased-risk-of-chronic-spontaneous-urticaria-in-patients-with-autoimmune-thyroid-diseases-a-nationwide-population-based-study
#6
Yoon Seob Kim, Kyungdo Han, Ji Hyun Lee, Nack In Kim, Joo Young Roh, Seong Jun Seo, Hae Jun Song, Min Geol Lee, Jee Ho Choi, Young Min Park
There was no previous population-based study on the comparison of the risk of chronic spontaneous urticaria (CSU) between autoimmune thyroid diseases (AITD) and age- and gender-matched controls. The primary objective of this study was to evaluate the risk of CSU after diagnosis of AITD using national registry data from Korea. The secondary objective was to evaluate other risk factors of CSU. Based on the disease code diagnoses in 2003-2005, we composed an AITD group (n=3,659) and an age- and gender-matched control group (n=18,295)...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28492006/evaluation-of-prolactin-levels-in-patients-with-newly-diagnosed-pemphigus-vulgaris-and-its-correlation-with-pemphigus-disease-area-index
#7
Vahideh Lajevardi, Zahra Hallaji, Maryam Daneshpazhooh, Narges Ghandi, Peyman Shekari, Sepideh Khani
BACKGROUND: Prolactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves' disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies...
June 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28489238/quality-of-life-outcomes-in-graves-disease-patients-after-total-thyroidectomy
#8
Lukas H Kus, Wilma M Hopman, Ian J Witterick, Jeremy L Freeman
Historically, research into surgical treatment of Graves disease has assessed subtotal rather than total thyroidectomy. Most clinicians now recommend total thyroidectomy, but little information is available regarding quality-of-life (QOL) outcomes for this procedure. Our aim was to assess QOL after total thyroidectomy. This is a retrospective, pilot study of patients with Graves disease who underwent total thyroidectomy from 1991 to 2007 at a high-volume tertiary referral center in Toronto, Canada. Questionnaires addressing disease-specific symptoms and global QOL concerns were sent to 54 patients...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28486791/rare-nox3-variants-confer-susceptibility-to-agranulocytosis-during-thyrostatic-treatment-of-graves-disease
#9
T S Plantinga, P Arts, G H Knarren, A H Mulder, I M Wakelkamp, A R Hermus, L A Joosten, M G Netea, P H Bisschop, W W de Herder, H J Beijers, I J de Bruin, C Gilissen, J A Veltman, A Hoischen, J W Smit, R T Netea-Maier
Agranulocytosis is a rare and serious adverse effect of antithyroid drugs, with unknown etiology. The present study aimed to uncover genetic susceptibility and underlying mechanisms of antithyroid drug-induced agranulocytosis (ATDAC). We studied two independent families with familial Graves' disease, of which several members developed ATDAC. In addition, six sporadic ATDAC patients with Graves' disease were investigated. Whole exome sequencing analysis of affected and unaffected family members was performed to identify genetic susceptibility variants for ATDAC, followed by functional characterization of primary granulocytes from patients and unrelated healthy controls...
May 9, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28480067/radiation-therapy-for-hepatobiliary-malignancies
#10
REVIEW
Jonathan W Lischalk, Michael C Repka, Keith Unger
Hepatobiliary malignancies represent a heterogeneous group of diseases, which often arise in a background of underlying hepatic dysfunction complicating their local management. Surgical resection continues to be the standard of care for hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC); unfortunately the majority of patients are inoperable at presentation. The aggressiveness of these lesions makes locoregional control of particular importance. Historical experience with less sophisticated radiotherapy resulted in underwhelming efficacy and oftentimes prohibitive liver toxicity...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28473357/atrioventricular-block-an-unusual-complication-of-graves-disease
#11
Akintayo Adesokan, Trisha Vigneswaran, Michal Ajzensztejn, Sujeev Mathur
We report the case of a 10-year-old girl treated with atenolol and carbimazole for tachycardia and hypertension associated with Graves' disease who developed symptomatic 2:1 heart block. 2:1 heart block resolved following cessation of atenolol, reduction in carbimazole dose and treatment of suspected tonsillitis. First-degree atrioventricular block persisted, but gradually normalised following improvement in thyroid status.
May 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28472357/thyroid-dysfunction-and-autoimmune-thyroid-diseases-among-atomic-bomb-survivors-exposed-in-childhood
#12
Misa Imaizumi, Waka Ohishi, Eiji Nakashima, Nobuko Sera, Kazuo Neriishi, Michiko Yamada, Yoshimi Tatsukawa, Ikuno Takahashi, Saeko Fujiwara, Keizo Sugino, Takao Ando, Toshiro Usa, Atsushi Kawakami, Masazumi Akahoshi, Ayumi Hida
Context: The risk of thyroid cancer increases and persists for decades among individuals exposed to ionizing radiation in childhood, while long-term effects of childhood exposure to medium to low doses radiation on thyroid dysfunction and autoimmune thyroid diseases have remained unclear. Objective: To evaluate radiation-dose responses for the prevalence of thyroid dysfunction and autoimmune thyroid disease among atomic -bomb survivors exposed in childhood. Design, Setting, and Participants: Hiroshima and Nagasaki atomic-bomb survivors who were younger than 10 years old at exposure underwent thyroid examinations at the Radiation Effects Research Foundation between 2007 and 2011, which was 62-66 years after the bombing...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28471814/sepsis-associated-30-day-risk-standardized-readmissions-analysis-of-a-nationwide-medicare-sample
#13
Brett C Norman, Colin R Cooke, E Wes Ely, John A Graves
OBJECTIVES: To determine national readmission rates among sepsis survivors, variations in rates between hospitals, and determine whether measures of quality correlate with performance on sepsis readmissions. DESIGN: Cross-sectional study of sepsis readmissions between 2008 and 2011 in the Medicare fee-for-service database. SETTING: Acute care, Medicare participating hospitals from 2008 to 2011. PATIENTS: Septic patients as identified by International Classification of Diseases, Ninth Revision codes using the Angus method...
April 29, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28471268/increased-cardiovascular-mortality-and-morbidity-in-patients-treated-for-toxic-nodular-goiter-compared-to-graves-disease-and-nontoxic-goiter
#14
Peter Giesecke, Mårten Rosenqvist, Viveka Frykman, Leif Friberg, Göran Wallin, Jonas Höijer, Stefan Lonn, Ove Törring
Background Previous research has suggested an increased risk of death and cardiovascular disease in patients treated for hyperthyroidism. However, studies on this subject are heterogenous, often based on old data, or have not considered the impact that treatment for hyperthyroidism might have on cardiovascular risk. It is also unclear whether long-term prognosis differs between Graves' disease and toxic nodular goiter. Our aim was to use a very large cohort built on recent data to assess whether improvements in cardiovascular care might have changed the prognosis over time...
May 4, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28469599/the-role-of-thyrotropin-receptor-activation-in-adipogenesis-and-modulation-of-fat-phenotype
#15
Mohd Shazli Draman, Michael Stechman, David Scott-Coombes, Colin M Dayan, Dafydd Aled Rees, Marian Ludgate, Lei Zhang
Evidence from clinical and experimental data suggests that thyrotropin receptor (TSHR) signaling is involved in energy expenditure through its impact on white adipose tissue (WAT) and brown adipose tissue (BAT). TSHR expression increases during mesenchymal stem cell (MSC) differentiation into fat. We hypothesize that TSHR activation [TSHR*, elevated thyroid-stimulating hormone, thyroid-stimulating antibodies (TSAB), or activating mutation] influences MSC differentiation, which contributes to body composition changes seen in hypothyroidism or Graves' disease (GD)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28467880/teprotumumab-for-thyroid-associated-ophthalmopathy
#16
RANDOMIZED CONTROLLED TRIAL
Terry J Smith, George J Kahaly, Daniel G Ezra, James C Fleming, Roger A Dailey, Rosa A Tang, Gerald J Harris, Alessandro Antonelli, Mario Salvi, Robert A Goldberg, James W Gigantelli, Steven M Couch, Erin M Shriver, Brent R Hayek, Eric M Hink, Richard M Woodward, Kathleen Gabriel, Guido Magni, Raymond S Douglas
BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. METHODS: We conducted a multicenter, double-masked, randomized, placebo-controlled trial to determine the efficacy and safety of teprotumumab, a human monoclonal antibody inhibitor of IGF-IR, in patients with active, moderate-to-severe ophthalmopathy...
May 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28465846/a-rare-complication-following-thyroid-percutaneous-ethanol-injection-plummer-adenoma
#17
Roberto Cesareo, Anda Mihaela Naciu, Valerio Pasqualini, Giuseppe Pelle, Silvia Manfrini, Gaia Tabacco, Angelo Lauria Pantano, Alessandro Casini, Roberto Cianni, Andrea Palermo
Percutaneous ethanol injection (PEI) is a technique used only for benign thyroid nodules, cystic or mixed cystic-solid with a large fluid component. It is a quite low-cost, safe, and outpatient method of treatment. Rare and severe complications have been described after PEI: jugular vein thrombosis and severe ethanol toxic necrosis of the larynx combined with necrotic dermatitis. Moreover, only four thyrotoxicosis cases due to Graves' disease have been reported. We report a case of 58-year-old female with a voluminous thyroid cystic nodule, occupying almost the entire left thyroid lobe...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28465796/adding-carbimazole-to-levothyroxine-increases-triiodothyronine-and-improves-outcome-in-patients-with-primary-hypothyroidism-a-preliminary-study-from-egypt
#18
Khaled Nagy Elfayoumy, Usama Bahgat Elgazzar, Mohamed Aboalabbas, Ahmed Salama Al-Adl
BACKGROUND: Many hypothyroid patients are not tolerant and not satisfied with levothyroxine (LT4). Older studies used large doses of both carbimazole and LT4 for Hashimoto's thyroiditis (HT), because Graves' disease (GD) and HT were considered as very closely related syndromes produced by thyroid autoimmunity. OBJECTIVE: The aim of the study was to determine the outcome after adding small doses of carbimazole to reduced doses of LT4 for patients with primary hypothyroidism, who are unable to tolerate LT4...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28464261/measuring-kinase-activity-a-global-challenge
#19
Marissa L Cann, Ian M McDonald, Michael P East, Gary L Johnson, Lee M Graves
The kinase enzymes within a cell, known collectively as the kinome, play crucial roles in many signaling pathways, including survival, motility, differentiation, stress response, and many more. Aberrant signaling through kinase pathways is often linked to cancer, among other diseases. A major area of scientific research involves understanding the relationships between kinases, their targets, and how the kinome adapts to perturbations of the cellular system. This review will discuss many of the current and developing methods for studying kinase activity, and evaluate their applications, advantages, and disadvantages...
May 2, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28458939/isotretinoin-as-a-possible-environmental-trigger-to-autoimmunity-in-genetically-susceptible-patients
#20
Jocelyn Nugroho, Bahareh Schweiger
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne...
2017: Case Reports in Pediatrics
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