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Graves disease

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https://www.readbyqxmd.com/read/29144795/relationship-between-the-effectiveness-of-inorganic-iodine-and-the-severity-of-graves-thyrotoxicosis-a-retrospective-study
#1
Akira Honda, Toyoyoshi Uchida, Koji Komiya, Hiromasa Goto, Kageumi Takeno, Junko Sato, Ruriko Suzuki, Miwa Himuro, Hirotaka Watada
OBJECTIVE: Inorganic iodine is often used to treat patients with Graves' thyrotoxicosis who do not tolerate thionamides due to adverse effects. However, predictors of continued inorganic iodine efficacy have not been fully elucidated yet. This study aimed to investigate the factors affecting the continued efficacy of potassium iodide (KI) in patients with Graves' thyrotoxicosis. METHODS: In this study, among 1197 patients with Graves' disease who were initially treated with thionamides, we retrospectively studied 24 consecutive Japanese patients whose treatment were changed to KI alone due to the adverse effects of thionamides...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143969/the-molecular-basis-of-cytotoxicity-of-%C3%AE-spinasterol-from-ganoderma-resinaceum-induction-of-apoptosis-and-overexpression-of-p53-in-breast-and-ovarian-cancer-cell-lines
#2
Nada K Sedky, Zaynab El Gammal, Amir E Wahba, Eman Mosad, Zahraa Y Waly, Amira Ali El-Fallal, Reem K Arafa, Nagwa El-Badri
OBJECTIVES: Despite advances in therapy of breast and ovarian cancers, they still remain among the most imperative causes of cancer death in women. The first can be considered one of the most widespread diseases among females, while the latter is more lethal and needs prompt treatment. Thus, the research field can still benefit from discovery of new compounds that can be of potential use in management of these grave illnesses. We hereby aimed to assess the antitumor activity of the phytosterol α-spinasterol isolated from Ganoderma resinaceum mushroom on human breast cancer cell lines (MCF-7, MDA-MB-231), as well as, on human ovarian cancer cell line (SKOV-3)...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29142837/preoperative-management-in-patients-with-graves-disease
#3
REVIEW
Eliana Piantanida
Graves' disease is the most frequent cause of hyperthyroidism in iodine-sufficient geographical areas and is characterized by the presence in patients' serum of autoantibodies directed against the thyrotropin receptor (TRAb) that cause overproduction and release of thyroid hormones. Clinical presentation results from both hyperthyroidism and underlying autoimmunity. The diagnosis is based on characteristic clinical features and biochemical abnormalities. If serum thyrotropin (TSH) is low, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations should be measured to distinguish between subclinical (with normal circulating thyroid hormones) and overt hyperthyroidism (with increased circulating thyroid hormones)...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29141802/examining-the-contributions-of-environmental-quality-to-pediatric-multiple-sclerosis
#4
Amy M Lavery, Amy T Waldman, T Charles Casper, Shelly Roalstad, Meghan Candee, John Rose, Anita Belman, Bianca Weinstock-Guttman, Greg Aaen, Jan-Mendelt Tillema, Moses Rodriguez, Jayne Ness, Yolanda Harris, Jennifer Graves, Lauren Krupp, Leslie Benson, Mark Gorman, Manikum Moodley, Mary Rensel, Manu Goyal, Soe Mar, Tanuja Chitnis, Teri Schreiner, Tim Lotze, Benjamin Greenberg, Ilana Kahn, Jennifer Rubin, Emmanuelle Waubant
BACKGROUND: Multiple sclerosis (MS) is a presumed autoimmune disease caused by genetic and environmental factors. It is hypothesized that environmental exposures (such as air and water quality) trigger the innate immune response thereby activating a pro-inflammatory cascade. OBJECTIVE: To examine potential environmental factors in pediatric MS using geographic information systems (GIS). METHODS: Pediatric MS cases and healthy controls were identified as part of an ongoing multicenter case-control study...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141603/detect-i-detect-ii-a-study-protocol-for-a-prospective-multicentre-observational-study-to-validate-the-uromark-assay-for-the-detection-of-bladder-cancer-from-urinary-cells
#5
Wei Shen Tan, Andrew Feber, Liqin Dong, Rachael Sarpong, Sheida Rezaee, Simon Rodney, Pramit Khetrapal, Patricia de Winter, Frelyn Ocampo, Rumana Jalil, Norman R Williams, Chris Brew-Graves, John D Kelly
BACKGROUND: Haematuria is a common finding in general practice which requires visual inspection of the bladder by cystoscopy as well as upper tract imaging. In addition, patients with non-muscle invasive bladder cancer (NMIBC) often require surveillance cystoscopy as often as three monthly depending on disease risk. However, cystoscopy is an invasive procedure which is uncomfortable, requires hospital attendance and is associated with a risk of urinary tract infection. We have developed the UroMark assay, which can detect 150 methylation specific alteration specific to bladder cancer using DNA from urinary sediment cells...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29138656/-hyperthyroidism-in-children-at-the-university-hospital-in-dakar-senegal
#6
Djibril Boiro, Demba Diédhiou, Babacar Niang, Djiby Sow, Mandiaye Mbodj, Anna Sarr, Aliou Abdoulaye Ndongo, Aliou Thiongane, Modou Guèye, Lamine Thiam, Ndiogou Seck, Yaay Joor Dieng, Abou Ba, Idrissa Demba Ba, Ibrahima Mané Diallo, Ousmane Ndiaye, Said Nourou Diop
Introduction: Hyperthyroidism in children is rare and constitutes a problem because of its psychosomatic impact. This study aimed to present an overview of the state of knowledge on these aspects in children from Dakar. Methods: We conducted a multicenter, descriptive study over a period of 15 years. We evaluated the epidemiological, clinical and etiologic aspects of hyperthyroidism in children. Results: 239 patients were included in the study with a prevalence of 2...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29137069/graves-disease-following-radioiodine-therapy-for-toxic-adenoma-clinical-case-report
#7
Guohua Shen, Futao Cui, Rui Huang, Anren Kuang
RATIONALE: There is a low risk of developing Graves disease (GD) with elevated thyrotropin receptor antibodies (TRAbs) in patients undergoing radioiodine therapy for toxic adenoma. PATIENT CONCERNS: An old female patient with a history of Hashimoto thyroiditis was referred to our department due to thyrotoxic symptoms. After the administration of radioiodine, a significant remission was achieved. However, after 4 months, she was referred to our department again due to recurrence of hyperthyroid symptoms...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29130077/study-of-the-factors-leading-to-fetal-and-neonatal-dysthyroidism-in-children-of-patients-with-graves-disease
#8
Maïa Banigé, Candice Estellat, Valerie Biran, Luc Desfrere, Valerie Champion, Alexandra Benachi, Yves Ville, Marc Dommergues, Pierre-Henri Jarreau, Mostafa Mokhtari, Claire Boithias, Frederic Brioude, Laurent Mandelbrot, Pierre-François Ceccaldi, Delphine Mitanchez, Michel Polak, Dominique Luton
Context: Neonatal hyperthyroidism was first described in 1912 and in 1964 was shown to be linked to transplacental passage of maternal antibodies. Few multicenter studies have described the perinatal factors leading to fetal and neonatal dysthyroidism. Objective: To show how fetal dysthyroidism (FD) and neonatal dysthyroidism (ND) can be predicted from perinatal variables, in particular, the levels of anti-thyrotropin receptor antibodies (TRAbs) circulating in the mother and child...
June 2017: J Endocr Soc
https://www.readbyqxmd.com/read/29127767/marine-lenhart-syndrome-in-two-adolescents-including-one-with-thyroid-cancer-a-case-series-and-review-of-the-literature
#9
REVIEW
Animesh Sharma
BACKGROUND: The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature. CONTENT: In this case report, two adolescent female patients with Marine-Lenhart syndrome, aged 15 and 16 years, exhibited biochemical evidence of hyperthyroidism, and were found to have unilateral hyperfunctioning thyroid nodules via thyroid scintigraphy...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29127744/-endocrine-orbitopathy-the-present-view-of-a-clinical-endocrinologist
#10
Jan Jiskra
Graves orbitopathy (GO) occurs in 25-50 % cases of Graves disease. Only in 5 % of patients the eye threatening GO is present. About 5-10 % and 10 % cases are present in euthyroid and hypothyroid patients respectively. All patients with GO should be assessed for activity (clinical activity score - CAS) and severity of the disease. Basic preconditions of the treatment are maintenance of euthyroidism, an effort to stop smoking, and referring of patients with moderate to severe and sight threatening GO to specialized thyroid eye centers...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29127443/astragaloside-iv-attenuates-orbital-inflammation-in-graves-orbitopathy-through-suppression-of-autophagy
#11
Hong Li, Yali Zhang, Jie Min, Long Gao, Ren Zhang, Yucheng Yang
INTRODUCTION: Graves' orbitopathy (GO) is an autoimmune inflammatory disorder affecting the orbit around the eye. Astragaloside IV (AS-VI) is the main active ingredient of the Chinese herbal medicine Huangqi (Radix Astragali Mongolici). AS-IV exhibits antioxidant and anti-inflammatory properties, and shows therapeutic potential in a number of ischemic and inflammatory diseases; however, its pharmaceutical activities in GO remain undefined. MATERIALS AND METHODS: In this study, we investigated the effects of AS-IV on interleukin (IL)-1β-induced orbital fibroblast inflammation in vitro and GO orbital inflammation and ocular histopathological changes in vivo, as well as the underlying mechanisms responsible for these effects...
November 10, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29125145/the-2017-doyne-lecture-the-orbit-as-a-window-to-systemic-disease
#12
REVIEW
A A McNab
A very large number of disorders affect the orbit, and many of these occur in the setting of systemic disease. This lecture covers selected aspects of orbital diseases with systemic associations in which the author has a particular clinical or research interest. Spontaneous orbital haemorrhage often occurs in the presence of bleeding diatheses. Thrombosis of orbital veins and ischaemic necrosis of orbital and ocular adnexal tissues occur with thrombophilic disorders, vasculitis, and certain bacterial and fungal infections...
November 10, 2017: Eye
https://www.readbyqxmd.com/read/29120123/the-value-of-multidetector-computed-tomography-of-orbits-in-globe-protrusion-in-comparison-to-hertel-exophthalmometry
#13
Igor Đorić, Miloš Žarković, Zoran Radojičić, Nikola Repac, Aleksandar Janićijević, Krešimir Rotim, Goran Tasić, Lukas Rasulić
The use of multidetector computed tomography (MDCT) is an integral part of contemporary diagnostics of Graves‘ orbitopathy. The aim of this study was to assess proptosis measurement by MDCT and to compare it to the current standard, Hertel exophthalmometry. A cross-sectional study was conducted at the Clinical Centre of Serbia and included 91 patients (19 male and 72 female) with verified Graves‘ orbitopathy. Globe protrusion measured by MDCT (globe protrusion, GPR) was correlated to Hertel measured protrusion (HR)...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29113356/prediction-of-thyroidal-131-i-effective-half-life-in-patients-with-graves-disease
#14
Ruiguo Zhang, Guizhi Zhang, Renfei Wang, Jian Tan, Yajing He, Zhaowei Meng
Purpose: Calculation of effective thyroidal half-life (Teff) of iodine-131((131)I) is cumbersome and tedious. The aim of this study was to investigate factors that could be used to predict Teff and to develop a Teff prediction model in Graves' disease patients. Methods: A total of 256 patients with GD were involved in this study. We investigated the influences of age, gender, disease duration, thyroid weight, antithyroid drugs, antithyroid drugs discontinuation period (ADP), thyroid function indexes, thyroid autoantibodies, thyroid-stimulating hormone receptor antibody (TRAb) level and radioactive iodine uptake (RAIU) values before (131)I therapy on Teff, applying univariate and multivariate analyses...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108702/the-use-of-potassium-iodide-in-graves-disease
#15
Dina M Elaraj, Thomas J Fahey
No abstract text is available yet for this article.
November 3, 2017: Surgery
https://www.readbyqxmd.com/read/29108701/impact-of-potassium-iodide-on-thyroidectomy-for-graves-disease-implications-for-safety-and-operative-difficulty
#16
Reese W Randle, Maria F Bates, Kristin L Long, Susan C Pitt, David F Schneider, Rebecca S Sippel
BACKGROUND: Potassium iodide often is prescribed prior to thyroidectomy for Graves' disease, but the effect of potassium iodide on the ease and safety of thyroidectomy for Graves' is largely unknown. METHODS: We conducted a prospective, cohort study of patients with Graves' disease undergoing thyroidectomy. For the first 8 months, no patients received potassium iodide; for the next 8 months, potassium iodide was added to the preoperative protocol for all patients...
November 3, 2017: Surgery
https://www.readbyqxmd.com/read/29108394/comparative-study-of-3-exophthalmometers-and-computed-tomographic-biometry
#17
Juliette Delmas, Jean-Marie Loustau, Sylvain Martin, Loïc Bourmault, Jean-Paul Adenis, Pierre-Yves Robert
PURPOSE: Accurate and reproducible exophthalmometry is mandatory to diagnose and follow-up orbital patients, especially in Graves disease. However, many variations are described among the different commercially available exophthalmometers. METHODS: Sixty patients, who underwent a cerebral computed tomography (CT) scan, were included. External prebicanthal segments (EPBCS) for right and left eyes (RE and LE), interorbital distance, and globe axial length were recorded by a first observer (O1), more experienced than a second (O2)...
November 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29103088/left-ventricular-functions-in-children-with-newly-diagnosed-graves-disease-a-single-center-study-from-upper-egypt
#18
Kotb Abbass Metwalley, Hekma Saad Farghaly, Abdelrahman Abdelhamid
This study aimed to evaluate the left ventricular (LV) functions in a cohort of children with Graves' disease (GD). This is a cross-sectional case-control study. It included 36 children with GD and 36 healthy children matched for age and gender. Thyroid hormones (TSH, FT4, and FT3) and anti-thyroid autoantibodies [anti-thyroid peroxidase (anti-TPO), thyrotropin receptor (TRAbs), and thyroglobulin antibodies] were measured. Conventional and tissue Doppler imaging (TDI) echocardiographies were used to assess left ventricular systolic and diastolic functions...
November 4, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29102101/iodinated-contrast-administration-resulting-in-cardiogenic-shock-in-patient-with-uncontrolled-graves-disease
#19
Wes Brundridge, Jack Perkins
BACKGROUND: Thyroid storm (also known as thyroid or thyrotoxic crisis) is part of the spectrum of thyrotoxicosis and represents the extreme end of that spectrum. The condition is quite rare, yet mortality rates are high and may approach 10-30%. CASE REPORT: A 34-year-old-man who had a history of Graves disease presented in atrial fibrillation with rapid ventricular response and mild congestive heart failure. During the course of his Emergency Department (ED) stay he deteriorated into cardiogenic shock...
October 25, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29096933/modified-lateral-orbital-wall-decompression-in-graves-orbitopathy-using-computer-assisted-planning
#20
S Spalthoff, P Jehn, R Zimmerer, M Rana, N-C Gellrich, J Dittmann
Graves' orbitopathy, a condition seen in the autoimmune syndrome Graves' disease, affects the fatty tissue and muscles inside the orbit. Graves' orbitopathy is associated with increasing exophthalmos and sometimes leads to compressive dysthyroid optic neuropathy, resulting in progressive vision loss. Dysthyroid compressive optic neuropathy, functional problems, and cosmetic problems are the main indications for surgical decompression of the orbit, especially if conservative treatment has not led to a reduction in symptoms...
October 30, 2017: International Journal of Oral and Maxillofacial Surgery
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