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Hui Zhang, Pengcheng Yu, Shengwei Zhong, Tingting Ge, Shasha Peng, Xiaoquan Guo, Zuohong Zhou
Telocytes (TCs), novel interstitial cells, have been identified in various organs of many mammals. However, information about TCs of lower animals remains rare. Herein, pancreatic TCs of the Chinese giant salamanders (Andrias davidianus) were identified by CD34 immunohistochemistry (IHC) and transmission electron microscopy (TEM). The IHC micrographs revealed CD34(+) TCs with long telopodes (Tps) that were located in the interstitium of the pancreas. CD34(+) TCs/Tps were frequently observed between exocrine acinar cells and were close to blood vessels...
September 20, 2016: Journal of Cellular and Molecular Medicine
Hui Zhang, Shengwei Zhong, Pengcheng Yu, Tingting Ge, Shasha Peng, Xiaoquan Guo, Zuohong Zhou
In this study, we attempt to identify gastric telocytes (TCs) of the Chinese giant salamander Andrias davidianus, by light microscopy, immunohistochemistry and transmission electron microscopy (TEM) methods. Toluidine blue staining showed TCs with one to two very thin and long telopodes (Tps) that were located in gastric lamina propria. Tps had characteristic structures, including podoms, podomers and dichotomous branching. Immunohistochemistry showed the existence of CD34(+)/PDGFRα(+) TCs with moniliform Tps in stroma and were close to gastric glands and blood vessels...
2016: Scientific Reports
Ping Yang, Xudong Zhu, Lingling Wang, Nisar Ahmed, Yufei Huang, Hong Chen, Qian Zhang, Shakeeb Ullah, Tengfei Liu, Dawei Guo, Sarfaraz Ahmed Brohi, Qiusheng Chen
Telocytes are a novel type of interstitial cells recently identified in many organs of mammals, but little information in the avian. So this study shows the latest findings associated with telocytes, with a special attention on the magnum of chicken oviduct, in the muscular layer and lamina propria by transmission electron microscopy. Telocytes are characterized by telopodes, which are thin and long prolongations, and a small amount of cytoplasm rich with mitochondria. Different shaped telocytes (spindle to triangular) depending on the number of prolongations...
September 1, 2016: Cell Transplantation
Dragos Cretoiu, Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Sanda Maria Cretoiu
Telocytes (TCs), located ubiquitously in the internal organs of vertebrates, are a heterogeneous, recently described, cell population of the stromal space. Characterized by lengthy cytoplasmic extensions that can reach tens of microns and are called telopodes (Tps), TCs are difficult to see using conventional microscopes. It was the electron microscopy which led to their first identification and Popescu's team the first responsible for the reconstructions indicating TCs 'organization' in a three-dimensional (3D) network that is believed to be accountable for the complex roles of TCs...
August 25, 2016: Seminars in Cell & Developmental Biology
Diane Catherine Wang, Xiangdong Wang
The concept of systems heterogeneity was firstly coined and explained in the Special Issue, as a new alternative to understand the importance and complexity of heterogeneity in cancer. Systems heterogeneity can offer a full image of heterogeneity at multi-dimensional functions and multi-omics by integrating gene or protein expression, epigenetics, sequencing, phosphorylation, transcription, pathway, or interaction. The Special Issue starts with the roles of epigenetics in the initiation and development of cancer heterogeneity through the interaction between permanent genetic mutations and dynamic epigenetic alterations...
August 20, 2016: Seminars in Cell & Developmental Biology
Dragos Cretoiu, Jiahong Xu, Junjie Xiao, Sanda M Cretoiu
Entering the new millennium, nobody believed that there was the possibility of discovering a new cellular type. Nevertheless, telocytes (TCs) were described as a novel kind of interstitial cell. Ubiquitously distributed in the extracellular matrix of any tissue, TCs are regarded as cells with telopodes involved in intercellular communication by direct homo- and heterocellular junctions or by extracellular vesicle (EVs) release. Their discovery has aroused the interest of many research groups worldwide, and many researchers regard them as potentially regenerative cells...
2016: International Journal of Molecular Sciences
Artur Pasternak, Jolanta Bugajska, Mirosław Szura, Jerzy A Walocha, Andrzej Matyja, Mariusz Gajda, Krystyna Sztefko, Krzysztof Gil
It has been reported that intake of ω-3 polyunsaturated fatty acids (PUFA) reduces the risk of coronary heart disease. It also influences the bile composition, decreasing biliary cholesterol saturation in the bile of patients with gallstones. In addition to bile composition disturbances, gallbladder hypomotility must be co-factor in the pathogenesis of cholelithiasis as it leads to the prolonged nucleation phase. Our current knowledge about gallbladder motility has been enhanced by the study of a population of newly described interstitial (stromal) cells - telocytes (TCs)...
August 5, 2016: Cell Transplantation
Te Liu, Suwei Wang, Qiong Li, Yongyi Huang, Chuan Chen, Jin Zheng
Premature ovarian failure (POF) refers to the presence of ovarian atrophic permanent amenorrhea in women under the age of 40. The pathogenesis of POF remains to be fully elucidated. Telocytes are a group of specialized cells with a small cell volume and very long cytoplasmic prolongations with dichotomous branching. Previous studies have indicated that telocytes function to support the trachea and serve as stem cell niches. Although it has been confirmed that telocytes are present in numerous organs in mammals, it remains to be determined whether they are present in ovarian tissues and whether they are involved in the development of POF...
September 2016: Molecular Medicine Reports
Dongli Song, Dragos Cretoiu, Sanda M Cretoiu, Xiangdong Wang
Telocytes (TCs) represent a new distinct type of interstitial cells found in many organs, including lungs. TCs are mainly defined by a small cellular body from which arise very long (hundreds of micrometers) extensions named telopodes. During the last years, TCs were characterized in respect with their microRNA profiles, gene features and proteome signatures. Also, the ultrastructural 3D configuration was further elucidated by the aid of the FIB-SEM technology. TCs are able to communicate by homo- and heterocellular contacts with neighboring cells and are also able to transfer genetic information and signaling molecules to influence other cells by means of extracellular vesicle release...
December 2016: Histology and Histopathology
Frank A Wollheim
No abstract text is available yet for this article.
July 21, 2016: Joint, Bone, Spine: Revue du Rhumatisme
Ivan Varga, Lubos Danisovic, Jan Kyselovic, Andrea Gazova, Peter Musil, Michal Miko, Stefan Polak
Key morphological discoveries in recent years have included the discovery of new cell populations inside the heart called cardiac telocytes. These newly described cells of the connective tissue have extremely long cytoplasmic processes through which they form functionally connected three-dimensional networks that connect cells of the immune system, nerve fibers, cardiac stem cells, and cardiac muscle cells. Based on their functions, telocytes are also referred to as "connecting cells" or "nurse cells" for cardiac progenitor stem cells...
May 19, 2016: Canadian Journal of Physiology and Pharmacology
Eetmad A Arafat
Telocytes (TCs) are newly described interstitial cells that might play a role in normal and pathological conditions. The aim of this study was designed to investigate its existence in the skin and skeletal muscle of one day old newborn rats and to study their ultrastructure and immunohistochemical characteristics. Ten rats (one day old newborn) were used in this study. Dorsal skin and femoral skeletal muscle samples were obtained and examined by CD117, CD34, semi-thin and ultrathin sections examination. Semi-thin sections examination revealed multiple spindle shape cells with cytoplasmic extension in the skin and in between muscle fibers...
July 2016: Acta Histochemica
Yan-Yan Li, Song Zhang, Yi-Gang Li, Yan Wang
Telocytes (TCs), a novel type of stromal cells, are crucial to cardiac renovation and regeneration. To dissect the pathophysiological effects of cardiac TCs in heart disease, it is essential to develop an effective method to isolate, culture, purify and characterize these cells. In the present study, cardiac TCs were isolated from the hearts of rats by enzymatic digestion. Histology and CD34/PDGFRα expression by flow cytometric assay were used to characterize the cultured cardiac TCs, which were purified by flow cytometric sorting and confirmed by immunofluorescence and electron microscopy...
August 2016: Molecular Medicine Reports
Yanyan Li, Xiuxiu Zhang, Juan Gao, Han Xiao, Ming Xu
Telocytes (TCs) are a novel type of interstitial cells that are thought to be involved in tissue regeneration and repair. However, the possible roles of TCs in vascular diseases remain unclear. In this study, we used a rat model of carotid artery balloon injury (CABI) to study the changes and potential roles of vascular TCs after vascular injury. Transmission electron microscopy (TEM) and CD34/vimentin immunolabeling were used to identify and quantify TCs in normal and injured carotid arteries. Quantitative immunofluorescence analysis revealed that, compared with the sham group, the number of TCs in the CABI group increased from 7...
July 2016: Science China. Life Sciences
L Urban, M Miko, M Kajanova, S Bozikova, H Mrazova, I Varga
BACKGROUND: Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement. METHODS: Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8±9.1) were stained for the expression of five different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1...
2016: Bratislavské Lekárske Listy
Siyi Fu, Hui Zhu, Siyi Li, Yalong Wang, Yihua Bei, Junjie Xiao
Telocytes (TCs) are a distinct type of stromal cells with extremely thin and long prolongations called telopodes (Tps). TCs have been ubiquitously reported in almost all tissues and organs across species including heart. TCs are distinct from fibroblasts as evidenced by ultrastructural characteristics, immunohistochemistry features, gene profiles, proteome features, and miRNA signatures. By means of heterocellular junctions and extracellular vesicles, TCs may be able to regulate cardiac stem cells, angiogenesis, and anti-fibrosis...
2016: Current Stem Cell Research & Therapy
Changqing Yang, Junjie Xiao
No abstract text is available yet for this article.
2016: Current Stem Cell Research & Therapy
Kelly C S Roballo, Natalia J N Gonçalves, Naira C G Pieri, Aline F Souza, André F C Andrade, Carlos E Ambrósio
The choroid plexus is a tissue on the central nervous system responsible for producing cerebrospinal fluid, maintaining homeostasis and neural stem cells support; though, all of its functions still unclear. This study aimed to demonstrate the niches of choroid plexus cells for a better understanding of the cell types and functions, using the porcine as the animal model. The collected material was analyzed by histology, immunohistochemistry, and cell culture. The cell culture was characterizated by immunocytochemistry and flow cytometry...
July 28, 2016: Neuroscience Letters
Nicolae Mirancea
Here we review on the infrastructure, relationships and putative role of a new cell phenotype termed telocyte. Ultrastructural and immunochemical characteristics of telocytes, their identification in different tissues, homo- and heterocellular telocyte's contacts and considerations concerning their putative role in normal as well as pathological conditions are largely presented. A special section of the paper is devoted to our opinion÷hypothesis concerning the possibility that, to some extent, endoneurial fibroblast dendritic phenotype (existed in the peripheral nerve endoneurium) can be assimilated to the telocyte or, at least to the telocyte-like...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Mugurel Constantin Rusu, Dragos Cretoiu, Alexandra Diana Vrapciu, Sorin Hostiuc, Dan Dermengiu, Vasile Sorin Manoiu, Sanda Maria Cretoiu, Nicolae Mirancea
Telocytes (TCs) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in various organs, however little is known about their presence in human trigeminal ganglion. To address this issue, samples of trigeminal ganglia were tested by immunocytochemistry for CD34 and examined by transmission electron microscopy (TEM). We found that TCs are CD34 positive and form networks within the ganglion in close vicinity to microvessels and nerve fibers around the neuronal-glial units (NGUs)...
June 2016: Cell Biology and Toxicology
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