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https://www.readbyqxmd.com/read/29452017/fractional-non-ablative-laser-assisted-drug-delivery-leads-to-improvement-in-male-and-female-pattern-hair-loss
#1
Ana Carina Junqueira Bertin, Adriana Vilarinho, Ana Lúcia Ariano Junqueira
Androgenetic alopecia, also known as male and female pattern hair loss, is a very prevalent condition; however, approved therapeutic options are limited. Fractionated laser has been proposed to assist in penetration of topical medications to the cutaneous tissue. We present four cases of androgenetic alopecia that underwent treatment with a non-ablative erbium glass fractional laser followed by the application of topical finasteride 0,05% and growth factors including basic fibroblast growth factor, insulin-like growth factor, vascular endothelial growth factor, and copper peptide 1%...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29449755/catalytic-liquefaction-of-human-feces-over-ni-tm-tio-2-catalyst-and-the-influence-of-operating-conditions-on-products
#2
Wenjia Wang, Lei Yang, Zhaosen Yin, Shengyan Kong, Wei Han, Jinglai Zhang
In this study, human feces were hydrothermal liquefied and converted into biocrude over Ni-Tm/TiO 2 catalyst. The influence of catalysts, reaction temperature, and holding time on the distribution of products and element content of biocrude was assessed. The biocrude yield increased to 53.16% with a reaction temperature of 330 °C, a holding time of 30 min, and adding Ni-Tm/TiO 2 catalyst while the liquefaction conversion peaked at 89.61%. The biocrude had an HHV of 36.64 MJ/kg and was similar to heavy crude oil...
February 1, 2018: Energy Conversion and Management
https://www.readbyqxmd.com/read/29448683/using-krf-ela-to-improve-gate-stacked-laalo%C3%A2-zro%C3%A2-indium-gallium-zinc-oxide-thin-film-transistors-with-novel-atmospheric-pressure-plasma-enhanced-chemical-vapor-deposition-technique
#3
Chien-Hung Wu, Kow-Ming Chang, Yi-Ming Chen, Bo-Wen Huang, Yu-Xin Zhang, Shui-Jinn Wang
Atmospheric pressure plasma-enhanced chemical vapor deposition (AP-PECVD) technique and KrF excimer laser annealing (ELA) were employed for the fabrication of indium gallium zinc oxide thin-film transistors (IGZO-TFTs). Device with a 150 mJ/cm2 laser annealing densities demonstrated excellent electrical characteristics with improved on/off current ratio of 4.7×107, high channel mobility of 10 cm2/V-s, and low subthreshold swing of 0.15 V/dec. The improvements are attributed to the adjustment of oxygen vacancies in the IGZO channel to an appropriate range of around 28...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448528/removal-of-waterborne-pathogen-by-nanomaterial-membrane-coupling-system
#4
Rong Cheng, Xing-Yan Xue, Li Liu, Jin-Lin Wang, Ya-Ping Liu, Zhi-Peng Shen, Tao Zhang, Xiang Zheng
The waterborne pathogenic viruses threaten human health. And the nanomaterial-membrane coupling system is promising in virus removal. In this study, phage MS2 was selected as the model virus to investigate the removal of virus with the coupling system. Results revealed that commercial nano TiO2 (Degussa Aeroxide P25) showed both of excellent adsorption and photocatalysis performance for virus removal compared with nano ZnO, nano Fe3O4, carbon nanotube, graphene, nano Ni and Nano TiO2 (anatase). In P25 photocatalysis process, the removal efficiency of phage MS2 increased with the increase of P25 concentration (0~1000 mg L-1), virus initial concentration (102~106 PFU mL-1), UV irradiation doses (5~120 mJ cm-2) and UV light intensity (0...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442703/microstructure-in-plane-magnetic-properties-and-surface-energy-of-co-60-fe-20-v-20-thin-films
#5
Wen-Jen Liu, Yuan-Tsung Chen, Wei-Hsiang Chan, Sung-Hsiang Fu, Te-Ho Wu
Co60Fe20V20 thin films with thicknesses ranging from 3 to 13 nm were sputtered onto a Si(100) substrate at room temperature (RT). Captured selected-area diffraction patterns (SADs) and high-resolution cross-sectional transmission electron microscopy (HR X-TEM) images revealed that the microstructures of the Co60Fe20V20 thin films were amorphous. The hysteresis loop of the thinner Co60Fe20V20 thin films displayed the in-plane magnetic anisotropy, possibly as a result of atmo-spheric exposure. A comparison of saturation magnetization (Ms) and thicknesses indicated a concave-down phenomenon due to magnetic coupling...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442039/design-and-production-of-methyl-jasmonate-nanoemulsions-using-experimental-design-technique-and-evaluation-of-its-anti-cancer-efficacy
#6
K Habibi, H Sepehri, L Delphi, M H Mirjalili, H Rafati
Methyl jasmonate (MJ), a plant-derived stress hormone, has been shown to be a promising anti-cancer agent with high selectivity toward cancerous cells. The aim of the present study was to design a MJ loaded nanoemulsion (NE) to overcome the low MJ water solubility and also improve its anti-cancer efficiency. Box-Behnken design (BBD) was employed to optimize the composition effect of three independent manufacturing variables on two responses including average droplet size and poly dispersity index (PDI). ANOVA analysis indicated that both of the studied responses were well fitted by resultant quadratic models with the coefficient of determinations (R2) 0...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440152/protocol-for-validation-of-the-4at-a-rapid-screening-tool-for-delirium-a-multicentre-prospective-diagnostic-test-accuracy-study
#7
Susan D Shenkin, Christopher Fox, Mary Godfrey, Najma Siddiqi, Steve Goodacre, John Young, Atul Anand, Alasdair Gray, Joel Smith, Tracy Ryan, Janet Hanley, Allan MacRaild, Jill Steven, Polly L Black, Julia Boyd, Christopher J Weir, Alasdair Mj MacLullich
INTRODUCTION: Delirium is a severe neuropsychiatric syndrome of rapid onset, commonly precipitated by acute illness. It is common in older people in the emergency department (ED) and acute hospital, but greatly under-recognised in these and other settings. Delirium and other forms of cognitive impairment, particularly dementia, commonly coexist. There is a need for a rapid delirium screening tool that can be administered by a range of professional-level healthcare staff to patients with sensory or functional impairments in a busy clinical environment, which also incorporates general cognitive assessment...
February 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29435761/fibroblasts-potentiate-melanoma-cells-in-vitro-invasiveness-induced-by-uv-irradiated-keratinocytes
#8
Njainday Pulo Jobe, Veronika Živicová, Alžběta Mifková, Daniel Rösel, Barbora Dvořánková, Ondřej Kodet, Hynek Strnad, Michal Kolář, Aleksi Šedo, Karel Smetana, Karolina Strnadová, Jan Brábek, Lukáš Lacina
Melanoma represents a malignant disease with steadily increasing incidence. UV-irradiation is a recognized key factor in melanoma initiation. Therefore, the efficient prevention of UV tissue damage bears a critical potential for melanoma prevention. In this study, we tested the effect of UV irradiation of normal keratinocytes and their consequent interaction with normal and cancer-associated fibroblasts isolated from melanoma, respectively. Using this model of UV influenced microenvironment, we measured melanoma cell migration in 3-D collagen gels...
February 12, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29434689/lower-energy-radial-shock-wave-therapy-improves-characteristics-of-hypertrophic-scar-in-a-rabbit-ear-model
#9
Jing-Chun Zhao, Bo-Ru Zhang, Kai Shi, Jian Wang, Qing-Hua Yu, Jia-Ao Yu
The aim of the present study was to investigate the effects of radial extracorporeal shock wave therapy (rESWT) on scar characteristics and transforming growth factor (TGF)-β1/Smad signaling in order to explore a potential modality for the treatment of hypertrophic scars (HS). The HS model was generated in rabbit ears, then rabbits were randomly divided into 3 groups: Lower (L)-ESWT [treated with rESWT with lower energy flux density (EFD) of 0.1 mJ/mm2], higher (H)-ESWT (treated with a higher EFD of 0.18 mJ/mm2) and the sham ESWT group (S-ESWT; no ESWT treatment)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434666/life-cycle-assessment-of-transportation-biofuels-from-hydrothermal-liquefaction-of-forest-residues-in-british-columbia
#10
Yuhao Nie, Xiaotao Bi
Background: Biofuels from hydrothermal liquefaction (HTL) of abundantly available forest residues in British Columbia (BC) can potentially make great contributions to reduce the greenhouse gas (GHG) emissions from the transportation sector. A life-cycle assessment was conducted to quantify the GHG emissions of a hypothetic 100 million liters per year HTL biofuel system in the Coast Region of BC. Three scenarios were defined and investigated, namely, supply of bulky forest residues for conversion in a central integrated refinery (Fr-CIR), HTL of forest residues to bio-oil in distributed biorefineries and subsequent upgrading in a central oil refinery (Bo-DBR), and densification of forest residues in distributed pellet plants and conversion in a central integrated refinery (Wp-CIR)...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29431710/effect-of-salinity-on-medium-and-low-pressure-uv-disinfection-of-vibrio-cholerae
#11
P Y Chen, X N Chu, L Liu, J Y Hu
The problem of biological invasions attributed to ballast water release is an ongoing problem that threatens ecosystems and human health. Ultraviolet (UV) radiation has been increasingly used for ballast water treatment mainly due to the advantages of short contact time and minimized harmful disinfection by products. In this study, the impact of salinity on the inactivation of Vibrio cholerae (NCTC 7253) was examined, and comparison of inactivation level and disinfection kinetics after medium-pressure (MP) (1 kW) and low-pressure (LP) (10 W) UV irradiation was made...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29431534/organisation-of-dietary-control-for-nutrition-training-intervention-involving-periodized-carbohydrate-cho-availability-and-ketogenic-low-cho-high-fat-lchf-diet
#12
Joanne G Mirtschin, Sara F Forbes, Louise E Cato, Ida A Heikura, Nicki Strobel, Rebecca Hall, Louise M Burke
We describe the implementation of a 3-week dietary intervention in elite race walkers at the Australian Institute of Sport, with a focus on the resources and strategies needed to accomplish a complex study of this scale. Interventions involved: traditional guidelines of high carbohydrate (CHO) availability for all training sessions (HCHO); a periodized CHO diet which integrated sessions with low CHO and high CHO availability within the same total CHO intake, and a ketogenic low-CHO high-fat diet (LCHF). 7-day menus and recipes were constructed for a communal eating setting to meet nutritional goals as well as individualized food preferences and special needs...
February 12, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29428894/optimizing-laser-crater-enhanced-raman-scattering-spectroscopy
#13
V N Lednev, P A Sdvizhenskii, M Ya Grishin, A N Fedorov, O V Khokhlova, V B Oshurko, S M Pershin
The laser crater enhanced Raman scattering (LCERS) spectroscopy technique has been systematically studied for chosen sampling strategy and influence of powder material properties on spectra intensity enhancement. The same nanosecond pulsed solid state Nd:YAG laser (532 nm, 10 ns, 0.1-1.5 mJ/pulse) was used for laser crater production and Raman scattering experiments for l-aspartic acid powder. Increased sampling area inside crater cavity is the key factor for Raman signal improvement for the LCERS technique, thus Raman signal enhancement was studied as a function of numerous experimental parameters including lens-to-sample distance, wavelength (532 and 1064 nm) and laser pulse energy utilized for crater production...
January 31, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29428778/base-catalyzed-hydrolysis-and-speciation-dependent-photolysis-of-two-cephalosporin-antibiotics-ceftiofur-and-cefapirin
#14
Alyson R Ribeiro, Holger V Lutze, Torsten C Schmidt
Lately, special attention has been given to veterinary cephalosporin antibiotics due to their broad activity spectrum and significant consumption. Indeed, the determination of hydrolytic and photolytic kinetics provides a better comprehension of the undesired persistence of cephalosporins in aqueous matrices. In this work, the two widely used veterinary antibiotics ceftiofur (CEF) and cefapirin (CEPA) showed high instability under alkaline conditions, degrading in few minutes at pH > 11. In buffered solutions at neutral pH and natural temperature (T = 22 ± 1 °C), both drugs presented moderate stability (t½ = 3 d, CEPA and 1...
December 22, 2017: Water Research
https://www.readbyqxmd.com/read/29428712/quantification-of-atmospheric-emissions-and-energy-metrics-from-simulated-clamp-kiln-technology-in-the-clay-brick-industry
#15
Oladapo Akinshipe, Gerrit Kornelius
The quantification of atmospheric emissions from clamp kilns in the clay brick industry has met with limited success globally. The complex configuration of clamp kilns using coal or other carbonaceous fuels and uncertainties regarding kiln combustion conditions, has proven to be a hurdle in measurement of emissions and standardization of process and energy metrics. To enable quantification of these metrics, a model kiln was designed to simulate operating conditions and configuration similar to transverse slice of a typical full-scale clamp kiln, but with lower capacity (20,000 to 35,000 bricks per cycle)...
February 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29427970/removal-of-antiretroviral-drugs-stavudine-and-zidovudine-in-water-under-uv254-and-uv254-h2o2-processes-quantum-yields-kinetics-and-ecotoxicology-assessment
#16
Danilo Russo, Antonietta Siciliano, Marco Guida, Roberto Andreozzi, Nuno M Reis, Gianluca Li Puma, Raffaele Marotta
The concentration of antiretroviral drugs in wastewater treatment plants (WWTP) effluents and surface waters of many countries has increased significantly due to their widespread use for HIV treatment. In this study, the removal of stavudine and zidovudine under UV254 photolysis or UV254/H2O2 was investigated in a microcapillary film (MCF) photoreactor, using minimal water samples quantities. The UV254 quantum yield of zidovudine, (2.357 ± 0.0589)·10-2 mol ein-1 (pH 4.0-8.0), was 28-fold higher that the yield of stavudine (8...
February 7, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29426899/far-uvc-light-a-new-tool-to-control-the-spread-of-airborne-mediated-microbial-diseases
#17
David Welch, Manuela Buonanno, Veljko Grilj, Igor Shuryak, Connor Crickmore, Alan W Bigelow, Gerhard Randers-Pehrson, Gary W Johnson, David J Brenner
Airborne-mediated microbial diseases such as influenza and tuberculosis represent major public health challenges. A direct approach to prevent airborne transmission is inactivation of airborne pathogens, and the airborne antimicrobial potential of UVC ultraviolet light has long been established; however, its widespread use in public settings is limited because conventional UVC light sources are both carcinogenic and cataractogenic. By contrast, we have previously shown that far-UVC light (207-222 nm) efficiently inactivates bacteria without harm to exposed mammalian skin...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29423833/assessment-of-improved-buccal-permeation-and-bioavailability-of-felodipine-microemulsion-based-cross-linked-polycarbophil-gel
#18
Mahendra Singh, Jovita Kanoujia, Poonam Parashar, Malti Arya, Chandra B Tripathi, V R Sinha, Shailendra K Saraf, Shubhini A Saraf
The oral bioavailability of felodipine (FEL) is very low, i.e., about 15%. This could be due to low water solubility and hepatic first-pass effect. The objective of the present study was to develop FEL microemulsion-based gel, to bypass the first pass effect, for buccal delivery. The optimized FEL microemulsion (OPT-MEF) was used to prepare buccoadhesive gels, with varying concentrations of hydroxypropyl methylcellulose (HPMC) E4M and polycarbophil (PCP), and evaluated. The cross-linking of the PCP gelling agent was done by adjusting the pH with a neutralizing agent, triethanolamine (TEA)...
February 8, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29422871/age-related-vascular-changes-affect-turbulence-in-aortic-blood-flow
#19
Hojin Ha, Magnus Ziegler, Martin Welander, Niclas Bjarnegård, Carl-Johan Carlhäll, Marcus Lindenberger, Toste Länne, Tino Ebbers, Petter Dyverfeldt
Turbulent blood flow is implicated in the pathogenesis of several aortic diseases but the extent and degree of turbulent blood flow in the normal aorta is unknown. We aimed to quantify the extent and degree of turbulece in the normal aorta and to assess whether age impacts the degree of turbulence. 22 young normal males (23.7 ± 3.0 y.o.) and 20 old normal males (70.9 ± 3.5 y.o.) were examined using four dimensional flow magnetic resonance imaging (4D Flow MRI) to quantify the turbulent kinetic energy (TKE), a measure of the intensity of turbulence, in the aorta...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29417318/gastrointestinal-and-hepatic-enzyme-activities-in-juvenile-silvery-black-porgy-sparidentex-hasta-fed-essential-amino-acid-deficient-diets
#20
Morteza Yaghoubi, Mansour Torfi Mozanzadeh, Omid Safari, Jasem G Marammazi
As amino acids (AAs) are vital molecules in the metabolism of all living organisms and are the building blocks of enzymes, a 6-week feeding trial was conducted for determining the influence of dietary essential amino acid (EAA) deficiencies on pancreatic, plasma, and hepatic enzyme activities in silvery-black porgy (initial weight 4.7 ± 0.01 g) juveniles. Eleven isoproteic (ca. 47%) and isoenergetic (ca. 20.5 MJ kg-1) diets were formulated including a control diet, in which 60% of dietary nitrogen were provided by intact protein (fish meal, gelatin, and wheat meal) and 40% by crystalline AA...
February 7, 2018: Fish Physiology and Biochemistry
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