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Susan C Potter, Karin K Coyle, Jill R Glassman, Sarah Kershner, Mary S Prince
OBJECTIVES: To evaluate the effectiveness of an evidence-based HIV/sexually transmitted infection (STI)/pregnancy prevention program for middle schools implemented by school staff in South Carolina. METHODS: Twenty-four schools, representing 3143 youths, participated in a randomized trial from 2011 to 2014. Students completed surveys before programming (fall of seventh grade), after completing the 2-year It's Your Game…Keep It Real program (spring of eighth grade), and 1-year postprogram (spring of ninth grade)...
September 2016: American Journal of Public Health
Francesc Marco, Michael J Dowzicky
Here we report in vitro activity data from the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) for tigecycline and comparators against Gram-positive and Gram-negative organisms collected from 27 medical centres in Spain between 2004 and 2014. Minimum inhibitory concentrations (MICs) were determined according to the broth microdilution methodology of the Clinical and Laboratory Standards Institute (CLSI) and susceptibility were determined according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) interpretive criteria...
September 2016: Journal of Global Antimicrobial Resistance
Atif Adnan, Arwin Ralf, Allah Rakha, Nefeli Kousouri, Manfred Kayser
Y-chromosomal short tandem repeat (Y-STR) markers are commonly used in forensic genetics. Male-specific haplotypes provided by commercial Y-STR kits allow discriminating between many - but not all - unrelated men, while they mostly fail to separate related ones. Aiming to improve male relative and paternal lineage differentiation, a set of 13 rapidly-mutating (RM) Y-STRs was previously identified and introduced to forensic Y-chromosome analysis. Recently, their value was highlighted by separating 99% of over 12,200 unrelated men from 111 global populations, as well as 29% of over 2500 male relative pairs, the vast majority were father-sons...
July 9, 2016: Forensic Science International. Genetics
J Czerwiński, K Antoszkiewicz, K Grygiel, E Karpeta, Ł Górski, M Dudkiewicz, D Lewandowska
BACKGROUND: In 2006, the National Transplants Registry, administered by the national transplant organization, was introduced in Poland for monitoring the results of organ transplantations. Statistical analysis is published yearly in Poltransplant Bulletin and publicly available on the website and reported to European institutions. The Transplants Registry cooperates with another registers functioning on-line, based on the web-net tool We present the formal analysis of data collected for the years 1998 to 2014...
June 2016: Transplantation Proceedings
Jacob Gehrman, Ingela Björholt, Eva Angenete, John Andersson, Jaap Bonjer, Eva Haglind
BACKGROUND: Previous studies regarding the comparative costs of laparoscopic and open surgery for rectal cancer provide ambiguous conclusions, and there are no large randomized trials or long-term follow-up. METHODS: A prospective cost-minimization analysis was carried out by using data of clinical resource use from the randomized controlled trial COLOR II. Some data needed for the health economic evaluation were not collected in the clinical trial; therefore, a retrospective data collection was made for COLOR II-patients operated at the largest participating Swedish hospital (n = 105)...
July 15, 2016: Surgical Endoscopy
Ranjodh Singh, Zhiping Zhou, Jamie Tisnado, Sofia Haque, Kyung K Peck, Robert J Young, Apostolos John Tsiouris, Sunitha B Thakur, Mark M Souweidane
OBJECTIVE Accurately determining diffuse intrinsic pontine glioma (DIPG) tumor volume is clinically important. The aims of the current study were to 1) measure DIPG volumes using methods that require different degrees of subjective judgment; and 2) evaluate interobserver agreement of measurements made using these methods. METHODS Eight patients from a Phase I clinical trial testing convection-enhanced delivery (CED) of a therapeutic antibody were included in the study. Pre-CED, post-radiation therapy axial T2-weighted images were analyzed using 2 methods requiring high degrees of subjective judgment (picture archiving and communication system [PACS] polygon and Volume Viewer auto-contour methods) and 1 method requiring a low degree of subjective judgment (k-means clustering segmentation) to determine tumor volumes...
July 8, 2016: Journal of Neurosurgery. Pediatrics
Rodney C Wade, Ashraf S Gorgey, Jennifer Hubert, Ryan Sumrell, Justin Bengel, Rehan Khan
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
A M Kögel, A Dinkel, B Marten-Mittag, J Baron, P Albers, C Arsov, B Hadaschik, M Hohenfellner, F Imkamp, M Kuczyk, J E Gschwend, K Herkommer
BACKGROUND: Self-concept consists of self-perceptions and is influenced by the life course of the person. OBJECTIVES: This study investigated associations between self-concept and erectile dysfunction (ED) in 45-year-old German men. MATERIALS AND METHODS: Forty-five-year-old, heterosexual men who had participated in the PROBASE-study were included. Erectile Function was evaluated using the International Index of Erectile Function (IIEF-6)...
May 2, 2016: Der Urologe. Ausg. A
Şenay Görücü Yılmaz, Sırma Geyik, Ayşe Münife Neyal, Nyarai D Soko, Hakan Bozkurt, Collet Dandara
Parkinson's disease (PD) is a frequently occurring neurodegenerative motor disorder adversely impacting global health. There is a paucity of biomarkers and diagnostics that can forecast susceptibility to PD. A new research frontier for PD pathophysiology is the study of variations in microRNA (miRNA) expression whereby miRNAs serve as "upstream regulators" of gene expression in relation to functioning of the dopamine neuronal pathways. Leucine-Rich Repeat Kinase 2 (LRRK2) is a frequently studied gene in PD...
April 2016: Omics: a Journal of Integrative Biology
Mohammad Sorowar Hossain, Mamtaz Begum, Md Mahmuduzzaman Mian, Shameema Ferdous, Shahinur Kabir, Humayun Kabir Sarker, Sabina Karim, Salma Choudhury, Asaduzzaman Khan, Zohora Jameela Khan, Henrike E Karim-Kos
BACKGROUND: Cancer burden among children and adolescents is largely unknown in Bangladesh. This study aims to provide a comprehensive overview on childhood and adolescent cancers and to contribute to the future strategies to deal with these diseases in Bangladesh. METHODS: Data on malignant neoplasms in patients aged less than 20 years diagnosed between 2001 and 2014 (N = 3143) in Bangladesh was collected by the National Institute of Cancer Research and Hospital and ASHIC Foundation...
2016: BMC Cancer
Denis Nam, Ryan M Nunley, Staci R Johnson, James A Keeney, John C Clohisy, Robert L Barrack
BACKGROUND: This study's purpose was to present our institution's experience with the use of a risk stratification protocol for venous thromboembolism (VTE) prophylaxis in joint arthroplasty in which "routine" risk patients receive a mobile compression device in conjunction with aspirin and "high"-risk patients receive warfarin for thromboprophylaxis. METHODS: This was a prospective study of patients undergoing primary or revision knee or hip arthroplasty. Exclusion criteria were patients with a current deep vein thrombosis, history of pulmonary embolism, chronic warfarin therapy, planned multiple surgeries, and prolonged postoperative immobilization...
June 2016: Journal of Arthroplasty
Nega Assefa, Lemessa Oljira, Negga Baraki, Melake Demena, Desalew Zelalem, Wondimye Ashenafi, Melkamu Dedefo
Kersa HDSS was established in 12 sub-districts of Kersa district, Eastern Hararge, Oromia Region, Ethiopia. The site is principally rural with two small towns (Kersa and Weter). The baseline census was conducted in 2007 and since then has been updated every 6 months, with registration of demographic and health events. Data are entered into the HRS-2 relational database. At baseline a total of 10,085 houses, 10,522 households and 50,830 people were registered. The sex ratio and number of persons per household were 1...
February 2016: International Journal of Epidemiology
Eyal Shemesh, Brianna J Lewis, Melissa Rubes, Michael A Ambrose, Meghan K Cahill, Christopher Knight, Scott H Sicherer, Rachel A Annunziato
OBJECTIVE: To evaluate whether a psychosocial screening program that included free and flexible access to mental health (MH) consultation resulted in increased rate of consultations. STUDY DESIGN: This is a post hoc review of a clinical screening program in a pediatric food allergy clinic in New York City. Screening was limited to 2 days per week, providing an opportunity to compare screened and nonscreened cohorts. Previous results from more than 1000 other families were analyzed to create the 1-page screening questionnaire...
January 2016: Journal of Pediatrics
Sabine Riethdorf, Sabrina Frey, Sonja Santjer, Malgorzata Stoupiec, Benjamin Otto, Lutz Riethdorf, Christina Koop, Waldemar Wilczak, Ronald Simon, Guido Sauter, Klaus Pantel, Volker Assmann
The transcription factor grainyhead-like 2 (GRHL2) plays a crucial role in various developmental processes. Although GRHL2 recently has attracted considerable interest in that it could be identified as a novel suppressor of the epithelial-to-mesenchymal transition, evidence is emerging that GRHL2 also exhibits tumour-promoting activities. Aim of the present study therefore was to help defining the relevance of GRHL2 for human cancers by performing a comprehensive immunohistochemical analysis of GRHL2 expression in normal (n = 608) and (n = 3,143) tumour tissues using tissue microarrays...
February 15, 2016: International Journal of Cancer. Journal International du Cancer
Bihan Tang, Yang Ge, Zhipeng Liu, Xu Liu, Peng Kang, Yuan Liu, Lulu Zhang
BACKGROUND: An earthquake struck Ludian in Yunnan province of China on August 3, 2014, resulting in 3143 injuries, 617 deaths, and 112 missing persons. Our study aimed at estimating the quality of life and associated determinants among medical rescuers after Ludian earthquake. METHODS: A cross-sectional survey was performed among personnel from three hospitals that assumed rescue tasks in Ludian earthquake. Descriptive statistics, t-tests, ANOVA and stepwise linear regression analysis were used for data analysis...
2015: Health and Quality of Life Outcomes
Chantel L Martin, Daniela Sotres-Alvarez, Anna Maria Siega-Riz
BACKGROUND: Preterm birth is one of the leading causes of neonatal morbidity in the United States. Despite decades of research, the etiology is largely unknown. OBJECTIVE: The purpose of our study was to examine the association between maternal dietary patterns during pregnancy and preterm birth. METHODS: This prospective cohort study used data from the PIN (Pregnancy, Infection, and Nutrition) study (n = 3143). Dietary intake was assessed at 26-29 wk of gestation by using a food-frequency questionnaire, and patterns were derived by using factor analysis and the Dietary Approaches to Stop Hypertension (DASH) diet...
August 2015: Journal of Nutrition
Bihan Tang, Yang Ge, Chen Xue, Peng Kang, Yuan Liu, Xu Liu, Zhipeng Liu, Wenya Yu, Lulu Zhang
BACKGROUND: An earthquake struck Ludian in Yunnan Province (China) on 3 August 2014, resulting in 3143 injuries, 617 deaths, and 112 missing persons. Our study aimed at estimating the health status and associated determinants among adolescent survivors after the Ludian earthquake. METHODS: A cross-sectional survey of 845 was conducted at the Ludian No. 1 Middle School. Descriptive statistics, t-tests, ANOVA and stepwise linear regression analysis were used for data analysis...
June 2015: International Journal of Environmental Research and Public Health
Laura Addis, Joo Wook Ahn, Richard Dobson, Abhishek Dixit, Caroline M Ogilvie, Dalila Pinto, Andrea K Vaags, Hilary Coon, Pauline Chaste, Scott Wilson, Jeremy R Parr, Joris Andrieux, Bruno Lenne, Zeynep Tumer, Vincenzo Leuzzi, Kristina Aubell, Hannele Koillinen, Sarah Curran, Christian R Marshall, Stephen W Scherer, Lisa J Strug, David A Collier, Deb K Pal
Copy-number variations (CNVs) are important in the aetiology of neurodevelopmental disorders and show broad phenotypic manifestations. We compared the presence of small CNVs disrupting the ELP4-PAX6 locus in 4,092 UK individuals with a range of neurodevelopmental conditions, clinically referred for array comparative genomic hybridization, with WTCCC controls (n = 4,783). The phenotypic analysis was then extended using the DECIPHER database. We followed up association using an autism patient cohort (n = 3,143) compared with six additional control groups (n = 6,469)...
September 2015: Human Mutation
Bhim B Ghaley, Harpinder S Sandhu, John R Porter
Land use and management intensity can influence provision of ecosystem services (ES). We argue that forest/agroforestry production systems are characterized by relatively higher C:O/C:N and ES value compared to arable production systems. Field investigations on C:N/C:O and 15 ES were determined in three diverse production systems: wheat monoculture (Cwheat), a combined food and energy system (CFE) and a beech forest in Denmark. The C:N/C:O ratios were 194.1/1.68, 94.1/1.57 and 59.5/1.45 for beech forest, CFE and Cwheat, respectively...
2015: PloS One
Greg Bowden, Hideyuki Kano, Ellen Caparosa, Seong-Hyun Park, Ajay Niranjan, John Flickinger, L Dade Lunsford
OBJECT: Non-small cell lung cancer (NSCLC) is the most frequent cancer that metastasizes to brain. Stereotactic radiosurgery (SRS) has become the management of choice for most patients with such metastatic tumors. Therefore, the authors endeavored to elucidate the survival and SRS outcomes for patients with NSCLC metastasis at their center. METHODS: In this single-institution retrospective analysis, the authors reviewed their experience with NSCLC metastasis during a 10-year period from 2001 to 2010...
April 2015: Journal of Neurosurgery
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