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https://www.readbyqxmd.com/read/28333992/improved-epidermal-barrier-formation-in-human-skin-models-by-chitosan-modulated-dermal-matrices
#1
Arnout Mieremet, Marion Rietveld, Samira Absalah, Jeroen van Smeden, Joke A Bouwstra, Abdoelwaheb El Ghalbzouri
Full thickness human skin models (FTMs) contain an epidermal and a dermal equivalent. The latter is composed of a collagen dermal matrix which harbours fibroblasts. Current epidermal barrier properties of FTMs do not fully resemble that of native human skin (NHS), which makes these human skin models less suitable for barrier related studies. To further enhance the resemblance of NHS for epidermal morphogenesis and barrier formation, we modulated the collagen dermal matrix with the biocompatible polymer chitosan...
2017: PloS One
https://www.readbyqxmd.com/read/28333338/drug-discovery-for-male-subfertility-using-high-throughput-screening-a-new-approach-to-an-unsolved-problem
#2
Sarah J Martins da Silva, Sean G Brown, Keith Sutton, Louise V King, Halil Ruso, David W Gray, Paul G Wyatt, Mark C Kelly, Christopher L R Barratt, Anthony G Hope
STUDY QUESTION: Can pharma drug discovery approaches be utilized to transform investigation into novel therapeutics for male infertility? SUMMARY ANSWER: High-throughput screening (HTS) is a viable approach to much-needed drug discovery for male factor infertility. WHAT IS KNOWN ALREADY: There is both huge demand and a genuine clinical need for new treatment options for infertile men. However, the time, effort and resources required for drug discovery are currently exorbitant, due to the unique challenges of the cellular, physical and functional properties of human spermatozoa and a lack of appropriate assay platform...
March 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28332762/the-effect-of-senior-obstetric-presence-on-maternal-and-neonatal-outcomes-in-uk-nhs-maternity-units-a-systematic-review-and-meta-analysis
#3
Holly E Reid, Dexter J L Hayes, Anja Wittkowski, Sarah Vause, Jo Whitcombe, Alexander E P Heazell
BACKGROUND: There is little consensus regarding the hypothesised link between obstetric consultant presence and maternal and neonatal outcomes. OBJECTIVES: To pool existing data on the impact of consultant presence on the outcomes of women who have given birth in UK NHS maternity units. SEARCH STRATEGY: Twelve databases, grey literature and reference lists were searched. SELECTION CRITERIA: Studies conducted in UK NHS maternity units comparing outcomes during lesser consultant presence versus increased consultant presence that reported mode of delivery and adverse maternal or neonatal outcomes...
March 23, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28332761/a-uk-national-survey-of-care-pathways-and-support-offered-to-patients-receiving-revision-surgery-for-prosthetic-joint-infection-in-the-highest-volume-nhs-orthopaedic-centres
#4
Andrew J Moore, Michael R Whitehouse, Rachael Gooberman-Hill, Jason Heddington, Andrew D Beswick, Ashley W Blom, Tim J Peters
BACKGROUND: Deep prosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. It is difficult to treat, and patients often require multiple major revision surgeries to eradicate the infection. Treatment can have negative and long-term impact on patients' quality of life. Understanding current service provision provides valuable information needed to design and evaluate support interventions for patients. AIM: This survey aimed to identify usual care pathways and support in UK National Health Service (NHS) orthopaedic centres for patients receiving revision surgery for PJI after hip or knee replacement...
March 23, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28328277/finding-the-right-frameworks
#5
Sam Foster
Sam Foster, Chief Nurse at Heart of England NHS Foundation Trust, discusses the issues around job descriptions, curricula and opportunities for progression needed to ensure care delivery is fit for existing and future patients.
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28328275/digitising-the-nhs-again
#6
Ian Peate
No abstract text is available yet for this article.
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28328266/the-high-cost-of-clinical-negligence-litigation-in-the-nhs
#7
John Tingle
John Tingle, Reader in Health Law at Nottingham Trent University, discusses a consultation document from the Department of Health on introducing fixed recoverable costs in lower-value clinical negligence claims.
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28328264/management-of-patients-with-psoriasis
#8
Stacey Croney
Stacey Croney, Clinical Nurse Lead Dermatology, Medway NHS Foundation Trust, Kent discusses the care of patients with psoriasis, including the latest drug treatments.
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28328263/the-nursing-associate-a-welcome-new-member-of-the-nhs-family
#9
Alan Glasper
Emeritus Professor Alan Glasper, from the University of Southampton, discusses the Nursing and Midwifery Council's announcement that it will regulate the new nursing associate role.
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28327185/economic-evaluation-of-interventions-delivered-by-primary-care-providers-to-improve-neurodevelopment-in-children-aged-under-5%C3%A2-years-protocol-for-a-scoping-review
#10
Karen M Edmond, Natalie A Strobel, Kimberley McAuley, Elizabeth Geelhoed, Lisa Hurt
BACKGROUND: Frequently cited benefit-cost ratios suggest that interventions to improve neurodevelopment have high economic returns when implemented during pregnancy and early childhood. However, there are many challenges when primary care providers implement these interventions at scale, and it is unclear how many research studies or programmes have examined cost-effectiveness and which methods were used. There are no current scoping or systematic reviews which have assessed economic evaluations of interventions delivered by primary care providers to improve child neurodevelopment...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28327039/-new-roles-are-no-replacement
#11
(no author information available yet)
Nursing associates and apprentices should not replace registered nurses, the chief executive of NHS England has told senior nurses and midwives.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28327037/meeting-patients-unmet-needs
#12
(no author information available yet)
Macmillan consultant nurse (breast) Victoria Harmer qualified with distinction in 1995 and has devoted her career to caring for patients with cancer. She specialised in breast cancer 17 years ago, after taking up a clinical nurse specialist post at London's St Mary's Hospital. She has been in her current role at Imperial College Healthcare NHS Trust since October 2016, and is also a published author and script adviser for television programmes featuring breast cancer storylines.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28327036/nurses-deserve-more-but-funds-are-tight-says-hunt
#13
Matthew Mckew
Health secretary Jeremy Hunt says he 'dearly' wants to increase nurse pay, but is restricted by limited resources and other pressures on the NHS.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28327025/managers-must-listen-to-nurses-in-nhs-crisis
#14
Helene Donnelly
Staff throughout the health and social care system are determined to deliver the best possible care and treatment to their patients, but, given current pressures on the system, we have to consider what is possible, and how far away it is from the 'best' care.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28327022/the-nhs-leads-positive-change-for-bme-people-in-the-workplace
#15
Yvonne Coghill
At the end of last month, I attended the launch of Race in the Workplace: The McGregor-Smith Review.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28327015/half-of-nurses-considering-leaving-nhs-survey-finds
#16
Erin Dean
More than half of nurses (52%) are considering quitting the NHS as work pressures continue to mount, an exclusive survey by Nursing Standard and the Sunday Mirror reveals.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28325172/travelling-for-treatment-does-distance-and-deprivation-affect-travel-for-intensity-modulated-radiotherapy-in-the-rural-setting-for-head-and-neck-cancer
#17
B Cosway, L Douglas, N Armstrong, A Robson
OBJECTIVE: NHS England has commissioned intensity-modulated radiotherapy for head and neck cancers from Newcastle hospitals for patients in North Cumbria. This study assessed whether travel distances affected the decision to travel to Newcastle (to receive intensity-modulated radiotherapy) or Carlisle (to receive conformal radiotherapy). METHODS: All patients for whom the multidisciplinary team recommended intensity-modulated radiotherapy between December 2013 and January 2016 were included...
March 22, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28324877/association-of-adherence-to-a-healthy-diet-with-cognitive-decline-in-european-and-american-older-adults-a-meta-analysis-within-the-chances-consortium
#18
Agnes A M Berendsen, Jae H Kang, Ondine van de Rest, Nicole Jankovic, Ellen Kampman, Jessica C Kiefte-de Jong, Oscar H Franco, M Arfan Ikram, Hynek Pikhart, Lena Maria Nilsson, Hermann Brenner, Paolo Boffetta, Snorri Bjorn Rafnsson, Deborah Gustafson, Andreas Kyrozis, Antonia Trichopoulou, Edith J M Feskens, Francine Grodstein, Lisette C P G M de Groot
AIM: To examine the association between a healthy diet, assessed by the Healthy Diet Indicator (HDI), and cognitive decline in older adults. METHODS: Data from 21,837 participants aged ≥55 years from 3 cohorts (Survey in Europe on Nutrition and the Elderly, a Concerted Action [SENECA], Rotterdam Study [RS], Nurses' Health Study [NHS]) were analyzed. HDI scores were based on intakes of saturated fatty acids, polyunsaturated fatty acids, mono- and disaccharides, protein, cholesterol, fruits and vegetables, and fiber...
March 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28322808/uk-nhs-home-office-agreement-undermines-patient-trust
#19
Becky McCall
No abstract text is available yet for this article.
March 18, 2017: Lancet
https://www.readbyqxmd.com/read/28320707/total-center-percutaneous-coronary-intervention-volume-and-30-day-mortality-a-contemporary-national-cohort-study-of-427%C3%A2-467-elective-urgent-and-emergency-cases
#20
Darragh O'Neill, Owen Nicholas, Chris P Gale, Peter Ludman, Mark A de Belder, Adam Timmis, Keith A A Fox, Iain A Simpson, Simon Redwood, Simon G Ray
BACKGROUND: The relationship between procedural volume and prognosis after percutaneous coronary intervention (PCI) remains uncertain, with some studies finding in favor of an inverse association and some against. This UK study provides a contemporary reassessment in one of the few countries in the world with a nationally representative PCI registry. METHODS AND RESULTS: A nationwide cohort study was performed using the national British Cardiovascular Intervention Society registry...
March 2017: Circulation. Cardiovascular Quality and Outcomes
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