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https://www.readbyqxmd.com/read/29793074/cross-linked-electrospun-cartilage-acellular-matrix-poly-caprolactone-co-lactide-co-glycolide-nanofiber-as-an-antiadhesive-barrier
#1
Jin Woo Lee, Joon Yeong Park, Seung Hun Park, Min Ju Kim, Bo Ram Song, Hee-Woong Yun, Tae Woong Kang, Hak Soo Choi, Young Jick Kim, Byoung Hyun Min, Moon Suk Kim
In this work, we chose cartilage acellular matrix (CAM) as a promising antiadhesive material because CAM effectively inhibits the formation of blood vessels, and we used electrospinning to prepare antiadhesive barriers. Additionally, we synthesized N-hydroxysuccinimide (NHS)-poly(caprolactone-co-lactide-co-glycolide)-NHS (MP) copolymers (to tune degradation) as a cross-linking agent for CAM. This is the first report on the development of electrospun cross-linked (Cx) CAM/MP (CA/P) nanofiber (NF) (Cx-CA/P-NF) with a tunable degradation period as an antiadhesive barrier...
May 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29792715/quantitative-analysis-of-peptide-matrix-interactions-in-lyophilized-solids-using-photolytic-labeling
#2
Yuan Chen, Elizabeth M Topp
Peptide-matrix interactions in lyophilized solids were explored using photolytic labeling and reversed phase high performance liquid chromatography (rp-HPLC) and mass spectrometric (MS) analysis. A model peptide (Ac-QELHKLQ-NHCH3 ) derived from salmon calcitonin was first labeled with a heterobifunctional cross-linker NHS-diazirine (succinimidyl 4,4'-azipentanoate; SDA) at Lys5 in solution, with ~ 100% conversion. The SDA labeled peptide was then formulated with the following excipients at a 1:400 molar ratio and lyophilized: sucrose, trehalose, mannitol, histidine, arginine, urea and NaCl...
May 24, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29791223/flexible-working-in-the-nhs
#3
Sam Foster
Sam Foster, Chief Nurse, Oxford University Hospitals, questions whether NHS policies around flexible working are fit for purpose.
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29791221/an-insight-into-living-with-diabetes
#4
Laura Lennard
Laura Lennard, Children's Diabetes Nurse, West Hertfordshire Hospitals NHS Trust, reflects on the challenges of encouraging behaviour change and the importance of understanding patients' real-life experiences.
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29791219/approaches-to-leadership-and-managing-change-in-the-nhs
#5
Melanie Lumbers
The NHS is continually changing as research evidence leads to new practices and technology transforms the workplace. Resistance to some changes may occur because of staff fears about adapting to and coping with new methods. This is where change models and leadership are important. This article discusses changes taking place in the NHS, and some theoretical models of change. Leadership styles are also discussed, including those most useful for the nurse to use when leading a team and implementing change.
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29790930/a-machine-learning-recommender-system-to-tailor-preference-assessments-to-enhance-person-centered-care-among-nursing-home-residents
#6
Gerald C Gannod, Katherine M Abbott, Kimberly Van Haitsma, Nathan Martindale, Alexandra Heppner
Background and Objectives: Nursing homes (NHs) using the Preferences for Everyday Living Inventory (PELI-NH) to assess important preferences and provide person-centered care find the number of items (72) to be a barrier to using the assessment. Research Design and Methods: Using a sample of n = 255 NH resident responses to the PELI-NH, we used the 16 preference items from the MDS 3.0 Section F to develop a machine learning recommender system to identify additional PELI-NH items that may be important to specific residents...
May 21, 2018: Gerontologist
https://www.readbyqxmd.com/read/29790251/chitosan-biphasic-calcium-phosphate-scaffolds-functionalized-with-bmp-2-encapsulated-nanoparticles-and-rgd-for-bone-regeneration
#7
Donglin Gan, Min Liu, Tong Xu, Kefeng Wang, Hui Tan, Xiong Lu
The BMP-2 encapsulated BNPs are prepared by a desolvation method, and are further coated by chitosan (CHI) coatings to obtain positively charged NPs (CBNPs). Va The BMP-2 encapsulated BNPs are prepared by a desolvation method, and are further coated by chitosan (CHI) coatings to obtain positively charged NPs (CBNPs) Advancements in bone tissue engineering require the improvement of tissue scaffolds, which should not only exhibit suitable mechanical properties and highly porous structures, but also effectively carry signaling molecules that can mediate bone formation and tissue regeneration...
May 23, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29789328/bapio-calls-for-single-visa-route-for-non-eu-doctors-to-boost-nhs-workforce-and-prevent-brain-drain
#8
Abi Rimmer
No abstract text is available yet for this article.
May 22, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29789227/cost-effectiveness-analysis-of-sensor-augmented-pump-therapy-with-low-glucose-suspend-in-patients-with-type-1-diabetes-mellitus-and-high-risk-of-hypoglycemia-in-spain
#9
Ignacio Conget, Pilar Martín-Vaquero, Stéphane Roze, Isabel Elías, Cristina Pineda, María Álvarez, Alexis Delbaere, Francisco Javier Ampudia-Blasco
OBJECTIVE: To compare the cost-effectiveness of sensor-augmented pump therapy (SAP) [continuous subcutaneous insulin infusion (CSII) plus real-time continuous glucose monitoring (RT-CGM)] with low glucose suspend (MiniMed™ Veo™) and CSII alone in patients with type 1 diabetes mellitus (T1DM) at high risk of hypoglycemia in Spain. METHODS: The IQVIA CORE Diabetes Model was used to estimate healthcare outcomes as life-years gained (LYGs) and quality-adjusted life years (QALYs), and to project lifetime costs...
May 19, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29789205/genetic-variants-related-to-urate-and-risk-of-parkinson-s-disease
#10
Katherine C Hughes, Xiang Gao, Eilis J O'Reilly, Iris Y Kim, Molin Wang, Marc G Weisskopf, Michael A Schwarzschild, Alberto Ascherio
INTRODUCTION: Higher urate concentrations have been associated with a lower risk of developing Parkinson's disease (PD) and with slower rates of clinical decline in PD patients. Whether these associations reflect a neuroprotective effect of urate is unclear. Our objective was to assess whether genetic variants that modify circulating urate levels are also associated with altered PD risk. METHODS: Participants were from three large ongoing cohort studies: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Cancer Prevention Study II Nutrition Cohort (CPS-IIN)...
May 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29788982/tisu-extracorporeal-shockwave-lithotripsy-as-first-treatment-option-compared-with-direct-progression-to-ureteroscopic-treatment-for-ureteric-stones-study-protocol-for-a-randomised-controlled-trial
#11
Samuel McClinton, Sarah Cameron, Kathryn Starr, Ruth Thomas, Graeme MacLennan, Alison McDonald, Thomas Lam, James N'Dow, Mary Kilonzo, Robert Pickard, Ken Anson, Frank Keeley, Neil Burgess, Charles Terry Clark, Sara MacLennan, John Norrie
BACKGROUND: Urinary stone disease is very common with an estimated prevalence among the general population of 2-3%. Ureteric stones are associated with severe pain as they pass through the urinary tract and have significant impact on patients' quality of life due to the detrimental effect on their ability to work and need for hospitalisation. Most ureteric stones can be expected to pass spontaneously with supportive care. However, between one-fifth and one-third of cases require an intervention...
May 22, 2018: Trials
https://www.readbyqxmd.com/read/29788136/an-experimental-evaluation-of-the-benefits-and-costs-of-providing-fertility-information-to-adolescents-and-emerging-adults
#12
J Boivin, E Koert, T Harris, L O'Shea, A Perryman, K Parker, C Harrison
STUDY QUESTION: Does the provision of fertility (compared to control) information affect fertility-related knowledge, perceived threat of infertility, anxiety, physical stress and fertility plans in adolescents and emerging adults? SUMMARY ANSWER: The provision of fertility information was associated with increased fertility knowledge (emerging adults) and greater infertility threat (adolescents and emerging adults). WHAT IS KNOWN ALREADY: According to fertility education research, adolescents and emerging adults know less than they should know about fertility topics...
May 17, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29787684/trends-and-variation-in-prescribing-of-low-priority-treatments-identified-by-nhs-england-a-cross-sectional-study-and-interactive-data-tool-in-english-primary-care
#13
Alex J Walker, Helen J Curtis, Seb Bacon, Richard Croker, Ben Goldacre
Objectives NHS England recently announced a consultation seeking to discourage the use of treatments it considers to be low-value. We set out to produce an interactive data resource to show savings in each NHS general practice and to assess the current use of these treatments, their change in use over time, and the extent and reasons for variation in such prescribing. Design Cross-sectional analysis. Setting English primary care. Participants English general practices. Main outcome measures We determined the cost per 1000 patients for prescribing of each of 18 treatments identified by NHS England for each month from July 2012 to June 2017, and also aggregated over the most recent year to assess total cost and variation among practices...
January 1, 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29787524/critical-appraisal-of-international-clinical-practice-guidelines-in-kidney-transplantation-using-the-appraisal-of-guidelines-for-research-and-education-agree-ii-tool-a-systematic-review
#14
Katriona Jane Marie OʼDonoghue, Rhiannon D Reed, Simon R Knight, John M O'Callaghan, Anam A Ayaz-Shah, Sevda Hassan, Annemarie Weissenbacher, Peter J Morris, Liset H M Pengel
BACKGROUND: Whilst Clinical Practice Guidelines (CPGs) are used for the development of local protocols in kidney transplantation (Ktx), the quality of their methodology is variable. This systematic review aimed to critically appraise international CPGs in all aspects of Ktx using the Appraisal of Guidelines for Research and Evaluation (AGREE) II tool. METHODS: CPGs in Ktx and donation published between 2010 and 2017 were identified from MEDLINE, Embase, National Guideline Clearinghouse, NHS and NICE Evidence Searches, and the websites of transplant societies...
May 22, 2018: Transplantation
https://www.readbyqxmd.com/read/29787261/selective-conversion-of-planar-trans-chlorins-into-highly-twisted-doubly-fused-porphyrins-or-chlorins-via-oxidative-fusion
#15
Nivedita Chaudhri, Nitika Grover, Muniappan Sankar
β-to- o-phenyl doubly fused porphyrins (DFPs) or chlorins (DFCs) were selectively synthesized by facile oxidative fusion of trans-chlorins using 2,3-dichloro-5,6-dicyano-1,4- benzoquinone (DDQ) in good-to-excellent yields (70-92%) under mild reaction conditions with high atom economy. The selectivity in product formation (difused porphyrin or chlorin) was controlled by the presence or absence of a Ni(II) ion in the macrocyclic core. Notably, nickel(II) trans-chlorins selectively yielded DFPs, whereas free-base trans-chlorins afforded only DFCs...
May 22, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29785281/impact-of-the-applied-simulated-and-integrated-learning-approach-on-nursing-assistants-knowledge-and-confidence-caring-for-frail-seniors-in-nursing-homes
#16
Veronique M Boscart, George Heckman, Meaghan Davey, Michelle Heyer, John P Hirdes
Background: Increasing importance is being placed on optimizing the role of Nursing Aides (NAs) in improving quality of care for nursing home (NH) residents. One approach to do so is to have NAs participate in assessments embedded within the Minimum Data Set (MDS). This pilot study aimed to design and evaluate the Applied Simulated and Integrated Learning Approach (ASILA) program, a novel innovative training program for NAs employed in NHs to enhance their ability to assess residents within an inter-professional framework...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29784655/lessons-identified-from-the-2017-manchester-and-london-terrorism-incidents-part-3-the-postincident-and-recovery-phase
#17
REVIEW
Paul Hunt
This is the third paper in a three-part series detailing the lessons identified during the National Health Service (NHS) England clinical debrief meetings which followed the response to the 2017 Manchester and London terrorist incidents. It covers the postincident and recovery phases including rehabilitation, bereavement support, psychological support, network and regional lessons, NHS communications and supply organisations. It also summarises the military application of these lessons and outlines the next steps for further development...
May 21, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29782077/mindfulness-based-cognitive-therapy-an-efficacy-study-for-mental-health-care-staff
#18
Ryan Askey-Jones
INTRODUCTION: Burnout is a major concern within the NHS impacting negatively on mental healthcare professionals. Evidence suggests that burnout can lead to reduced productivity and reduced quality of care for patients. Mindfulness-based interventions (MBIs) have demonstrated effectiveness in mitigating burnout for healthcare professionals; however no previous research has directly reported correlations between burnout and mindfulness. AIM: Does mindfulness-based cognitive therapy (MBCT) reduce burnout amongst mental healthcare professionals and are there any direct correlations between mindfulness and burnout itself?...
May 21, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29780892/understanding-barriers-to-the-introduction-of-precision-medicines-in-non-small-cell-lung-cancer-a-qualitative-interview-protocol
#19
Stuart Wright, Gavin Daker-White, William Newman, Katherine Payne
Background: While precision medicines targeting genetic mutations and alterations in non-small cell lung cancer (NSCLC) have been available since 2010, their adoption into clinical practice has been slow. Evidence suggests that a number of barriers, such as insufficient clinician knowledge, a need for training of test providers, or a lack of specific clinical guidelines, may slow the implementation of precision in general. However, little attention has been given to the barriers to providing precision medicines in NSCLC...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29780033/public-attitudes-in-england-towards-the-sharing-of-personal-data-following-a-mass-casualty-incident-a-cross-sectional-study
#20
G James Rubin, Rebecca Webster, Antonia N Rubin, Richard Amlot, Nick Grey, Neil Greenberg
OBJECTIVES: To assess public attitudes towards data sharing to facilitate a mental health screening programme for people caught up in a mass casualty incident. DESIGN: Two, identical, cross-sectional, online surveys, using quotas to ensure demographic representativeness of people aged 18-65 years in England. Participants were randomly allocated to consider a scenario in which they witness a terrorism-related radiation incident or mass shooting, after which a police officer records their contact details...
May 20, 2018: BMJ Open
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