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https://www.readbyqxmd.com/read/27914364/structure-based-exploration-and-exploitation-of-the-s4-subsite-of-norovirus-3cl-protease-in-the-design-of-potent-and-permeable-inhibitors
#1
Anushka C Galasiti Kankanamalage, Yunjeong Kim, Athri D Rathnayake, Vishnu C Damalanka, Pathum M Weerawarna, Sean T Doyle, Amer F Alsoudi, D M Padmasankha Dissanayake, Gerald H Lushington, Nurjahan Mehzabeen, Kevin P Battaile, Scott Lovell, Kyeong-Ok Chang, William C Groutas
Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitute a serious public health concern. There are currently no approved human vaccines or norovirus-specific small-molecule therapeutics or prophylactics. Norovirus 3CL protease has recently emerged as a potential therapeutic target for the development of anti-norovirus agents...
November 14, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27914021/surface-modified-cobalt-ferrite-nanoparticles-for-rapid-capture-detection-and-removal-of-pathogens-a-potential-material-for-water-purification
#2
Raghvendra A Bohara, Nanasaheb D Throat, Nayeem A Mulla, Shivaji H Pawar
Enteric infections resulting from the consumption of contaminated drinking water, inadequate supply of water for personal hygiene, and poor sanitation take a heavy toll worldwide, and developing countries are the major sufferers. Consumption of microbiologically contaminated water leads to diseases such as amoebiasis, cholera, shigellosis, typhoid, and viral infections leading to gastroenteritis and hepatitis B. The present investigation deals with the development of effective method to capture and eliminate microbial contamination of water and improve the quality of water and thus decreasing the contaminated waterborne infections...
December 2, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27912886/medicinal-plants-and-natural-molecules-with-in-vitro-and-in-vivo-activity-against-rotavirus-a-systematic-review
#3
REVIEW
Gopalsamy Rajiv Gandhi, Paula Gurgel Barreto, Bruno Dos Santos Lima, Jullyana de Souza Siqueira Quintans, Adriano Antunes de Souza Araújo, Narendra Narain, Lucindo Jose Quintans-Júnior, Ricardo Queiroz Gurgel
BACKGROUND: Rotaviruses can cause life-threatening health disorders, such as severe dehydrating gastroenteritis and diarrhea in children. Vaccination is the main preventive strategy to reduce rotavirus diarrhea and the severity of episodes, but vaccines are not fully effective and new episodes may occur, even in vaccinated children. The WHO recommends oral rehydration therapy and zinc supplementation for rotavirus-induced diarrhea management. There is little preclinical evidence to support the use of phytotherapeutics in the management of rotaviral infections...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27910936/genome-analysis-of-campylobacter-concisus-strains-from-patients-with-inflammatory-bowel-disease-and-gastroenteritis-provides-new-insights-into-pathogenicity
#4
Heung Kit Leslie Chung, Alfred Tay, Sophie Octavia, Jieqiong Chen, Fang Liu, Rena Ma, Ruiting Lan, Stephen M Riordan, Michael C Grimm, Li Zhang
Campylobacter concisus is an oral bacterium that is associated with inflammatory bowel disease. C. concisus has two major genomospecies, which appear to have different enteric pathogenic potential. Currently, no studies have compared the genomes of C. concisus strains from different genomospecies. In this study, a comparative genome analysis of 36 C. concisus strains was conducted including 27 C. concisus strains sequenced in this study and nine publically available C. concisus genomes. The C. concisus core-genome was defined and genomospecies-specific genes were identified...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909946/norovirus-gii-17-outbreak-linked-to-an-infected-post-symptomatic-food-worker-in-a-french-military-unit-located-in-france
#5
Marc-Antoine Sanchez, Simon-Pierre Corcostégui, Charles-Arnaud De Broucker, Olivier Cabre, Stéphanie Watier-Grillot, Sylvie Perelle, Katia Ambert-Balay, Vincent Pommier de Santi
In February 2016, an outbreak of gastroenteritis occurred in a French military unit located in Poitiers, France. Attack rate was of 34% (103/300). A case-control study identified association between illness and cake consumption. Stool samples were tested positive for Norovirus GII.17 for one patient and one post-symptomatic food worker (FW). The FW presented vomiting one day before cake preparation. The NoV strain was probably spread through food worker hand contact. Prevention of Norovirus foodborne outbreaks implies new guidelines for FWs management in France and Europe...
December 1, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27909068/use-of-multiplex-pcr-to-rapidly-diagnose-febrile-patients-during-a-gastroenteritis-outbreak-among-ebola-virus-treatment-unit-workers
#6
Tom O Evans, T Fominyam, S W Matthews, M S Bailey, E J Hutley
Multiplex PCR can provide rapid diagnosis for patients presenting with an acute undifferentiated febrile illness. Such technology is useful in deployed settings, where access to conventional microbiological diagnosis is limited. It was used in Sierra Leone to guide management of febrile healthcare workers, in whom Ebola virus disease was a possible cause. In particular, it informed appropriate antibiotic treatment while minimising the risk to clinicians of exposure to the causative organism.
December 1, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27908796/detection-of-novel-gii-17-norovirus-in-argentina-2015
#7
Juan I Degiuseppe, Karina A Gomes, María F Hadad, Gabriel I Parra, Juan A Stupka
During the winter of 2014-2015 a novel GII.17 norovirus strain emerged as a cause of large gastroenteritis outbreaks in Asia; displacing the long-term predominant strain, GII.4. Although sporadically detected, the emerging GII.17 virus was described in North America and Europe. In this study, we describe the presence of this novel strain in Argentina (South America), and provide new information on the genetic diversity of GII.17 noroviruses. Ten stool samples from individuals (1-88years old; median: 5years old) experiencing gastroenteritis symptoms from San Martín de los Andes, Argentina were tested for Norovirus using RT-PCR...
November 28, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27907974/-salmonellosis-a-real-threat-for-infants
#8
Václav Musil, Lenka Krbková, Peter Mikolášek, Lukáš Homola, Adriana Braunová
Salmonella spp. are a common cause of bacterial gastroenteritis. In infants, Salmonella infection is uncommon, posing a higher risk for a severe course. The authors present a case of a 3-month-old infant with suspected Salmonella sepsis. Also discussed are the correct approach to therapy and potential errors in the treatment of the youngest age groups.
September 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27903324/epidemiological-and-serological-investigation-of-a-waterborne-campylobacter-jejuni-outbreak-in-a-danish-town
#9
K Gaardbo Kuhn, G Falkenhorst, H-D Emborg, T Ceper, M Torpdahl, K A Krogfelt, S Ethelberg, K Mølbak
Following an unusually heavy rainfall in June 2009, a community-wide outbreak of Campylobacter gastroenteritis occurred in a small Danish town. The outbreak investigation consisted of (1) a cohort study using an e-questionnaire of disease determinants, (2) microbiological study of stool samples, (3) serological study of blood samples from cases and asymptomatic members of case households, and (4) environmental analyses of the water distribution system. The questionnaire study identified 163 cases (respondent attack rate 16%)...
December 1, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27902379/genetic-characterization-of-emergent-gii-17-norovirus-variants-from-2013-to-2015-in-nanjing-china
#10
Xuan Wang, Xuefei Du, Wei Yong, Mengkai Qiao, Min He, Limin Shi, Baofu Guo, Lei Hong, Yun Jiang, Guoxiang Xie, Jie Ding
During the 2014/15 winter season, a newly emergent GII.P17-GII.17 variant overwhelmed currently dominant GII.4 viruses, causing outbreaks of acute gastroenteritis in China and Japan. In Nanjing area, this novel GII.17 variant was first identified in a sporadic case of acute gastroenteritis in July 2013, 18 months ahead of reports from other parts of China. In this study, epidemiological features and genotyping of noroviruses from 2013 to 2015 were depicted. Twenty-eight local GII.17 sequences of capsid N-terminus originating from July 2013 to August 2015 were aligned, among which complete genome of seven strains obtained from two outbreaks and five sporadic cases was extensively characterized...
November 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902376/detection-of-a-novel-equine-like-g3-rotavirus-associated-with-acute-gastroenteritis-in-brazil
#11
Sylvia F S Guerra, Luana S Soares, Patrícia S Lobo, Edvaldo T Penha Júnior, Edivaldo C Sousa Júnior, Delana A M Bezerra, Lívia R Vaz, Alexandre C Linhares, Joana D P Mascarenhas
Genotype G3P[8] of rotavirus A (RVA) is detected worldwide, usually associated with Wa-like constellation and exhibiting a long RNA migration pattern. More recently, a novel intergenogroup, G3P[8] reassortant variant with a short electropherotype has emerged in Asia, Oceania and Europe, denoting an overall potential of unusual rotavirus strains. During a RVA surveillance in Brazil, G3P[8] strains were found displaying a short electropherotype pattern, which had not been detected before in this region. This study aims to characterize the complete genomes of 10 G3P[8] strains detected in Northern region of Brazil...
October 18, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27900889/campylobacter-jejuni-strains-coresistant-to-tetracycline-and-ciprofloxacin-in-patients-with-gastroenteritis-in-croatia
#12
Merica Carev, Ana Kovačić, Anita Novak, Marija Tonkić, Ana Jerončić
BACKGROUND: Antibiotic-resistant Campylobacter jejuni strains are rapidly emerging worldwide. Here, we aimed to determine the antibiotic-resistance patterns and genetic structure of C. jejuni from stool samples of symptomatic patients in Dalmatia, the largest Croatian county. METHODS: In a population-based laboratory surveillance programme for campylobacteriosis in Dalmatia from May 2012 to May 2013, C. jejuni (n = 76) were collected from stool samples of all the patients hospitalized with gastroenteritis and matched positive outpatients (n = 77)...
November 30, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27899409/variation-in-diagnostic-testing-and-hospitalization-rates-in-children-with-acute-gastroenteritis
#13
Carrie H Lind, Matt Hall, Donald H Arnold, Whitney Browning, David P Johnson, Gregory Plemmons, Nusrat Zaman, Derek J Williams
No abstract text is available yet for this article.
December 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27899145/bibliometric-analysis-of-publications-on-campylobacter-2000-2015
#14
Waleed M Sweileh, Samah W Al-Jabi, Ansam F Sawalha, Adham S AbuTaha, Sa'ed H Zyoud
BACKGROUND: Campylobacter species are widespread zoonotic pathogens. Campylobacter jejuni causes a form of gastroenteritis called campylobacteriosis. Campylobacter drug resistance is considered a serious threat. In order to better understand national and international research output on Campylobacter, we conducted this bibliometric overview of publications on Campylobacter. This study can be used to assess extent of interaction and response of researchers, food regulators, and health policy makers to global burden of campylobacateriosis...
November 29, 2016: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/27895976/microscopic-colitis-in-patients-with-mild-duodenal-damage-a-new-clinical-and-pathological-entity-lymphocytic-enterocolitis
#15
Gabriele Antonio Bonagura, Davide Giuseppe Ribaldone, Sharmila Fagoonee, Nicoletta Sapone, Gian Paolo Caviglia, Giorgio Maria Saracco, Marco Astegiano, Rinaldo Pellicano
AIM: To evaluate the potential association between mild duodenal damage and microscopic colitis (MC). METHODS: We retrospectively included 105 consecutive patients with type I Marsh-Oberhuber duodenal damage and negativity for immunoglobulin A anti-endomysium and anti-tissue transglutaminase. The following parameters were analyzed: Sex, age at execution of esophagogastroduodenoscopy, duodenal damage, and number of intraepithelial lymphocytes at biopsies, prevalence of Helicobacter pylori infection, age at execution of colonoscopy, macroscopic and microscopic features of colonoscopy, family history of gastrointestinal and autoimmune diseases, smoking habits, biochemical parameters of inflammation and autoimmunity, use of proton pump inhibitors or nonsteroidal anti-inflammatory drugs, adverse reactions to drugs or foods, pathologies known to be associated with celiac disease or MC, living on a gluten-free diet or on a gluten-low diet for at least 1 mo...
November 15, 2016: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/27895859/dysbiosis-of-fecal-microbiota-and-high-frequency-of-citrobacter-klebsiella-spp-and-actinomycetes-in-patients-with-irritable-bowel-syndrome-and-gastroenteritis
#16
Leila Ganji, Masoud Alebouyeh, Mohammad Hassan Shirazi, Seyed Saeed Eshraghi, Abbas Mirshafiey, Naser Ebrahimi Daryani, Mohammad Reza Zali
AIM: This study was aimed to characterize putative differences of fecal microbiota between irritable bowel syndrome (IBS) and gastroenteritis patients and healthy controls. BACKGROUND: New evidence proposed that gut microbiota has a deep effect on the balance between health and disease. PATIENTS AND METHODS: The presence of Clostridium difficile, Campylobacter spp., Enterobacteriacea and Staphylococci were detected in the samples using selective and specific culture media...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27895857/frequency-of-vana-vanb-and-vanh-variants-amongst-vancomycin-resistant-enterococci-isolated-from-patients-in-central-region-of-iran
#17
Jaafar Rezvani, Reza Nasr, Fatemeh T Shamsabadi, Mohammad Reza Akbari Eidgahi
AIM: The aim of this study was to investigate the VRE frequency and the rate of each gene in isolated enterococci from patients with intestinal infection in the central region of Iran. BACKGROUND: Enterococci infections are a public health growing concern due to the glycopeptide antibiotics resistance especially vancomycin. Genes, vanA, B, and H contribute to the influence of vancomycin-resistant enterococci (VRE). PATIENTS AND METHODS: This study was conducted from January to July 2014 in Shahrood university hospital...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27895856/genetic-characterization-of-cryptosporidium-spp-among-patients-with-gastrointestinal-complaints
#18
Reza Ranjbar, Kaveh Baghaei, Ehsan Nazemalhosseini Mojarad
AIM: This study investigated subtypes of Cryptosporidium in patients with gastrointestinal complaints in Tehran, Iran. BACKGROUND: Cryptosporidium, an intracellular protozean parasite, is among the major causative agents of gastroenteritis disorders in humans. It also causes water-borne and food-borne outbreaks of diarrheal diseases. PATIENTS AND METHODS: A total of 1685 fecal samples were collected from patients with gastrointestinal complaints who had been referred to clinical laboratories Tehran, Iran...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27895844/effect-of-human-rotavirus-vaccine-on-severe-diarrhea-in-african-infants
#19
Shabir A Madhi, Nigel A Cunliffe, Duncan Steele, Desirée Witte, Mari Kirsten, Cheryl Louw, Bagrey Ngwira, John C Victor, Paul H Gillard, Brigitte B Cheuvart, Htay H Han, Kathleen M Neuzil
BACKGROUND: Rotavirus is the most common cause of severe gastroenteritis among young children worldwide. Data are needed to assess the efficacy of the rotavirus vaccine in African children. METHODS: We conducted a randomized, placebo-controlled, multicenter trial in South Africa (3166 infants; 64.1% of the total) and Malawi (1773 infants; 35.9% of the total) to evaluate the efficacy of a live, oral rotavirus vaccine in preventing severe rotavirus gastroenteritis...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27895289/management-prevention-and-treatment-of-canine-leishmaniosis-in-north-eastern-spain-an-online-questionnaire-based-survey-in-the-province-of-girona-with-special-emphasis-on-new-preventive-methods-canileish-vaccine-and-domperidone
#20
S Lladró, A Picado, C Ballart, M Portús, M Gállego
Knowledge of how canine leishmaniosis (CanL) is being managed clinically and its epidemiology is very important, since dogs are the main reservoir of human leishmaniosis. This study reports the results obtained through a questionnaire-based survey of veterinary practitioners in Girona province, a recognised, but non-documented endemic area in north-eastern Spain. The primary objective was to obtain data on the clinical management of CanL, focusing particularly on new preventive methods and therapeutic tools...
November 28, 2016: Veterinary Record
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