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https://www.readbyqxmd.com/read/29150915/epidemiology-of-rhdv2-lagovirus-europaeus-gi-2-in-free-living-wild-european-rabbits-in-portugal
#1
C Rouco, J Abrantes, A Serronha, A M Lopes, E Maio, M J Magalhães, E Blanco, J Bárcena, P J Esteves, N Santos, P C Alves, P Monterroso
As the detection of the first outbreak of a novel aetiological agent of rabbit haemorrhagic disease commonly called RHDV2 or RHDVb (Lagovirus europaeus/GI.2, henceforth GI.2) in France in 2010, the virus rapidly spread throughout continental Europe and nearby islands such as Great Britain, Sardinia, Sicily, the Azores and the Canary Islands among others. The outbreaks of this new lagovirus cause important economic losses in rabbitries, and ecological disruptions by affecting the conservation of rabbit-sensitive top predators...
November 17, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29150366/optimal-ultrasound-criteria-for-grading-stenosis-of-the-superficial-femoral-artery
#2
Mingjie Gao, Yang Hua, Xinyu Zhao, Lingyun Jia, Jie Yang, Beibei Liu
This retrospective study determined the duplex ultrasound scanning criteria for detecting 50%-69% and 70%-99% stenosis of the superficial femoral artery (SFA). Examinations of 278 limbs in 185 patients with peripheral arterial disease were performed. Duplex ultrasound scanning was used to measure the diameter of the vascular lumen, the peak systolic velocity (PSV) at the stenotic segment of the SFA (PSVst), the segment proximal to the stenosis (PSVpro) and the popliteal artery (PSVpop, distal to the stenosis)...
November 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29150004/dynamics-of-indel-profiles-induced-by-various-crispr-cas9-delivery-methods
#3
Michael Kosicki, Sandeep S Rajan, Flaminia C Lorenzetti, Hans H Wandall, Yoshiki Narimatsu, Emmanouil Metzakopian, Eric P Bennett
The introduction of CRISPR/Cas9 gene editing in mammalian cells is a scientific breakthrough, which has greatly affected basic research and gene therapy. The simplicity and general access to CRISPR/Cas9 reagents has in an unprecedented manner "democratized" gene targeting in biomedical research, enabling genetic engineering of any gene in any cell, tissue, organ, and organism. The ability for fast, precise, and efficient profiling of the double-stranded break induced insertions and deletions (indels), mediated by any of the available programmable nucleases, is paramount to any given gene targeting approach...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29149352/prognostic-potential-of-markers-of-bone-turnover-in-delayed-healing-tibial-diaphyseal-fractures
#4
Malhar Kumar, Dnyaneshwar Shelke, Saumil Shah
INTRODUCTION: Clinical and radiographic examinations detect delayed or nonunion only after the event has occurred. Biochemical markers of bone turnover (BTMs) are promising laboratory tools that offer an early insight into the likelihood of delayed union. We hypothesized that BTMs display temporal variations following fractures and the behavior of BTMs differ between normal and delayed union of fractures. METHODS: This was a prospective study of patients with closed fracture of tibia treated with intramedullary, interlocking nailing...
November 17, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29149215/longitudinal-survey-of-two-serotine-bat-eptesicus-serotinus-maternity-colonies-exposed-to-eblv-1-european-bat-lyssavirus-type-1-assessment-of-survival-and-serological-status-variations-using-capture-recapture-models
#5
Emmanuelle Robardet, Christophe Borel, Marie Moinet, Dorothée Jouan, Marine Wasniewski, Jacques Barrat, Franck Boué, Elodie Montchâtre-Leroy, Alexandre Servat, Olivier Gimenez, Florence Cliquet, Evelyne Picard-Meyer
This study describes two longitudinal serological surveys of European Bat Lyssavirus type 1 (EBLV-1) antibodies in serotine bat (Eptesicus serotinus) maternity colonies located in the North-East of France. This species is currently considered as the main EBLV-1 reservoir. Multievent capture-recapture models were used to determine the factors influencing bat rabies transmission as this method accounts for imperfect detection and uncertainty in disease states. Considering the period of study, analyses revealed that survival and recapture probabilities were not affected by the serological status of individuals, confirming the capacity of bats to be exposed to lyssaviruses without dying...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29147936/effect-of-breeding-method-and-season-on-pregnancy-rate-and-embryonic-and-fetal-losses-in-lactating-nili-ravi-buffaloes
#6
Arslan Qayyum, Usman Arshad, Muhammad Rizwan Yousuf, Nasim Ahmad
The aim of this study was to determine the effect of breeding method and season on pregnancy rate and cumulative embryonic and fetal losses in Nili-Ravi buffalo. Estrus detection was performed twice a day by teaser buffalo bull for 1 hour each. A 2 × 2 factorial design was used to address the breeding method and season. Buffaloes (n = 130) exhibiting estrus were randomly assigned to be bred either in peak breeding season (PBS; n = 80) or low breeding season (LBS; n = 50). Within each season, buffaloes were divided to receive either natural service (NS; n = 65) or artificial insemination (AI; n = 65)...
November 16, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29146902/single-molecule-multiplexed-nanopore-protein-screening-in-human-serum-using-aptamer-modified-dna-carriers
#7
Jasmine Y Y Sze, Aleksandar P Ivanov, Anthony E G Cass, Joshua B Edel
The capability to screen a range of proteins at the single-molecule level with enhanced selectivity in biological fluids has been in part a driving force in developing future diagnostic and therapeutic strategies. The combination of nanopore sensing and nucleic acid aptamer recognition comes close to this ideal due to the ease of multiplexing, without the need for expensive labelling methods or extensive sample pre-treatment. Here, we demonstrate a fully flexible, scalable and low-cost detection platform to sense multiple protein targets simultaneously by grafting specific sequences along the backbone of a double-stranded DNA carrier...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146462/individual-serum-bile-acid-profiling-in-rats-aids-in-human-risk-assessment-of-drug-induced-liver-injury-due-to-bsep-inhibition
#8
Steven Cepa, David Potter, Lisa Wong, Leah Schutt, Jacqueline Tarrant, Jodie Pang, Xiaolin Zhang, Roxanne Andaya, Laurent Salphati, Yingqing Ran, Le An, Ryan Morgan, Jonathan Maher
Drug-induced liver injury (DILI) has been the most frequent cause of post-marketing drug withdrawals in the last 50years. The multifactorial nature of events that precede severe liver injury in human patients is difficult to model in rodents due to a variety of confounding or contributing factors that include disease state, concurrent medications, and translational species differences. In retrospective analyses, a consistent risk factor for DILI has been the inhibition of the Bile Salt Export Pump (BSEP). One compound known for potent BSEP inhibition and severe DILI is troglitazone...
November 13, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29144732/ratiometric-detection-of-intracellular-lysine-and-ph-with-one-pot-synthesized-dual-emissive-carbon-dots
#9
Wei Song, Wenxiu Duan, Yinghua Liu, Zhongju Ye, Yonglei Chen, Hongli Chen, Shengda Qi, Jiang Wu, Dan Liu, Lehui Xiao, Cuiling Ren, Xingguo Chen
Recently, the development of new fluorescent probes for the ratiometric detection of target objects inside living cells has received great attention. Normally, the preparation, modification as well as conjugation procedures of these probes are complicated. On this basis, great efforts have been paid to establish convenient method for the preparation of dual emissive nanosensor. In this work, a functional dual emissive carbon dots (dCDs) was prepared by a one-pot hydrothermal carbonization method. The dCDs exhibits two distinctive fluorescence emission peaks at 440 and 624 nm with the excitation at 380 nm...
November 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29144728/simultaneous-analysis-of-a-non-lipidated-protein-and-its-lipidated-counterpart-enabling-quantitative-investigation-of-protein-lipidation-s-impact-on-cellular-regulation
#10
Agnesa Shala-Lawrence, Melanie Jane Blanden, Svetlana M Krylova, Soumyashree A Gangopadhyay, Stanislav S Beloborodov, James L Hougland, Sergey N Krylov
Here we introduce Protein-Lipidation Quantitation (PLQ) - the first method for quantitative analysis of both a substrate and a product of protein lipidation in a biologically relevant context. Such analysis is required to study roles of protein lipidation in cellular regulation. In PLQ, the substrate is fused with a fluorescent protein to facilitate quantitative detection of both the non-lipidated substrate and the lipidated product. When expressed in cells with endogenous lipidation activity, the substrate is intracellularly lipidated...
November 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29144214/circadian-rhythms-of-trematode-parasites-applying-mixed-models-to-test-underlying-patterns
#11
Emily R Hannon, Dana M Calhoun, Sindhu Chadalawada, Pieter T J Johnson
Circadian rhythms of parasites and their hosts can influence processes such as transmission, pathology and life cycle evolution. For trematode parasites that depend on free-living infectious stages (i.e. cercariae) to move among host species, the timing of parasite release is hypothesized to increase the likelihood of contacting a host. Yet, a persistent challenge in studying such biorhythms involves selection of appropriate analytical techniques. Here, we extend a generalized linear mixed modelling (GLMM) framework to cosinor analyses, thereby allowing flexibility in the statistical distribution of the response variable, incorporation of multiple covariates and inclusion of hierarchical grouping effects...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29143137/segmental-biventricular-analysis-of-myocardial-function-using-high-temporal-and-spatial-resolution-tissue-phase-mapping
#12
Marius Menza, Daniela Föll, Jürgen Hennig, Bernd Jung
OBJECTIVE: Myocardial dysfunction of the right ventricle (RV) is an important indicator of RV diseases, e.g. RV infarction or pulmonary hypertension. Tissue phase mapping (TPM) has been widely used to determine function of the left ventricle (LV) by analyzing myocardial velocities. The analysis of RV motion is more complicated due to the different geometry and smaller wall thickness. The aim of this work was to adapt and optimize TPM to the demands of the RV. MATERIALS AND METHODS: TPM measurements were acquired in 25 healthy volunteers using a velocity-encoded phase-contrast sequence and kt-accelerated parallel imaging in combination with optimized navigator strategy and blood saturation...
November 15, 2017: Magma
https://www.readbyqxmd.com/read/29142392/quantitative-analysis-of-benzyl-isothiocyanate-in-salvadora-persica-extract-and-dental-care-herbal-formulations-using-reversed-phase-c18-high-performance-liquid-chromatography-method
#13
Maged Saad Abdel-Kader, Y T Kamal, Prawez Alam, Mohammed Hamed Alqarni, Ahmed Ibrahim Foudah
Context: Benzyl isothiocyanate is the active antimicrobial agent in Salvadora persica (siwak) widely used in Islamic countries for oral hygiene. Aims: Quantification of benzyl isothiocyanate in the ethanol extract of S. persica and some dental care herbal formulations labeled to contain siwak. Settings and Design: Simple and sensitive high-performance liquid chromatography method was designed. Subjects and Methods: Separation was achieved on reverse phase C18 (250 mm × 4...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142122/adaptive-immune-responses-following-senecavirus-a-infection-in-pigs
#14
Mayara F Maggioli, Steve Lawson, Marcelo de Lima, Lok R Joshi, Tatiane C Faccin, Fernando V Bauermann, Diego G Diel
Senecavirus A (SVA), an emerging picornavirus of swine, causes vesicular disease (VD) that is clinically indistinguishable from foot-and-mouth disease (FMD) in pigs. Many aspects of SVA interactions with the host and the host immune responses to infection, however, remain unknown. In the present study, humoral and cellular immune responses to SVA were evaluated following infection in pigs. We show that SVA infection elicited an early and robust neutralizing antibody (NA) response, which coincided with and was strongly correlated with VP2- and VP3-specific IgM responses...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29140287/interaction-between-diethyldithiocarbamate-and-cu-ii-on-gold-in-non-cyanide-wastewater
#15
Nguyễn Hoàng Ly, Thanh Danh Nguyen, Kyung-Duk Zoh, Sang-Woo Joo
A surface-enhanced Raman scattering (SERS) detection method for environmental copper ions (Cu(2+)) was developed according to the vibrational spectral change of diethyldithiocarbamate (DDTC) on gold nanoparticles (AuNPs). The ultraviolet-visible (UV-Vis) absorption spectra indicated that DDTC formed a complex with Cu(2+), showing a prominent peak at ~450 nm. We found Raman spectral changes in DDTC from ~1490 cm(-1) to ~1504 cm(-1) on AuNPs at a high concentration of Cu(2+) above 1 μM. The other ions of Zn(2+), Pb(2+), Ni(2+), NH₄⁺, Mn(2+), Mg(2+), K⁺, Hg(2+), Fe(2+), Fe(3+), Cr(3+), Co(2+), Cd(2+), and Ca(2+) did not produce such spectral changes, even after they reacted with DDTC...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29140167/intra-tester-reliability-and-construct-validity-of-a-hip-abductor-eccentric-strength-test
#16
Richard A Brindle, D David Ebaugh, Clare E Milner
CONTEXT: Side-lying hip abductor strength tests are commonly used to evaluate muscle strength. In a 'break' test the tester applies sufficient force to lower the limb to the table while the patient resists. The peak force is postulated to occur while the leg is lowering, thus representing the participant's eccentric muscle strength. However, it is unclear whether peak force occurs before or after the leg begins to lower. OBJECTIVES: To determine intra-rater reliability and construct validity of a hip abductor eccentric strength test...
November 15, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29139031/in-vivo-analysis-of-the-anti-atrial-fibrillatory-proarrhythmic-and-cardiodepressive-profiles-of-dronedarone-as-a-guide-for-safety-pharmacological-evaluation-of-antiarrhythmic-drugs
#17
Yoshiyuki Motokawa, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Hiroshi Yamazaki, Atsushi Sugiyama
Anti-atrial fibrillatory, proarrhythmic and cardiodepressive profiles of dronedarone were analyzed using the halothane-anesthetized beagle dogs (n = 4) to create a standard protocol for clarifying both efficacy and adverse effects of anti-atrial fibrillatory drugs. Intravenous administration of dronedarone hydrochloride in doses of 0.3 and 3 mg/kg over 30 s attained the peak plasma concentrations of 61 and 1248 ng/mL, respectively, reflecting sub- to supra-therapeutic ones. The low dose decreased the left ventricular contraction and mean blood pressure, which were enhanced at the high dose...
November 14, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29138635/nmr-confirmation-and-hplc-quantification-of-javamide-i-and-javamide-ii-in-green-coffee-extract-products-available-in-the-market
#18
Jae B Park
Javamide-I/javamide-II are phenolic amides found in coffee. Recent reports suggested that they may contain several biological activities related to human health. Therefore, there is emergent interest about their quantities in coffee-related products. Green coffee extract is a powder extract made of unroasted green coffee beans, available as a dietary supplement. However, there is little information about the amounts of javamide-I/javamide-II in green coffee extract products in the market. Therefore, in this paper, javamide-I/javamide-II were extracted from green coffee extract products and their identifications were confirmed by NMR...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/29138230/head-to-head-comparison-of-global-and-regional-two-dimensional-speckle-tracking-strain-versus-cardiac-magnetic-resonance-tagging-in-a-multicenter-validation-study
#19
Mihaela Silvia Amzulescu, Hélène Langet, Eric Saloux, Alain Manrique, Laurianne Boileau, Alisson Slimani, Pascal Allain, Clotilde Roy, Christophe de Meester, Agnès Pasquet, Mathieu De Craene, David Vancraeynest, Anne-Catherine Pouleur, Jean-Louis J Vanoverschelde, Bernhard L Gerber
BACKGROUND: Despite widespread use to characterize and refine prognosis, validation data of two-dimensional (2D) speckle tracking (2DST) echocardiography myocardial strain measurement remain scarce. METHODS AND RESULTS: Global and regional subendocardial peak-systolic Lagrangian longitudinal (LS) and circumferential strain (CS) by 2DST and 2D-tagged (2DTagg) cardiac magnetic resonance imaging were compared against sonomicrometry in a dynamic heart phantom and among each other in 136 patients included prospectively at 2 centers...
November 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29137964/oral-glucose-tolerance-test-and-continuous-glucose-monitoring-to-assess-diabetes-development-in-cystic-fibrosis-patients
#20
María Clemente León, Laura Bilbao Gassó, Antonio Moreno-Galdó, Ariadna Campos Martorrell, Silvia Gartner Tizzano, Diego Yeste Fernández, Antonio Carrascosa Lezcano
INTRODUCTION: Patients with cystic fibrosis (CF) undergo a slow and progressive process toward diabetes. Oral glucose tolerance test (OGTT) is recommended to diagnose impaired glucose levels in these patients. Continuous glucose monitoring (CGM) measures glucose profiles under real-life conditions. OBJECTIVE: To compare OGTT and CGM results in CF patients. METHODS: Paired OGTT and 6-day CGM profiles (146.2±9.1h/patient) were performed in 30 CF patients aged 10-18 years...
November 11, 2017: Endocrinología, diabetes y nutrición
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