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https://www.readbyqxmd.com/read/28544776/comparison-of-histologic-margin-status-in-low-grade-cutaneous-and-subcutaneous-canine-mast-cell-tumours-examined-by-radial-and-tangential-sections
#1
C B Dores, M Milovancev, D S Russell
BACKGROUND: Radial sections are widely used to estimate adequacy of excision in canine cutaneous mast cell tumours (MCTs); however, this sectioning technique estimates only a small fraction of total margin circumference. This study aimed to compare histologic margin status in grade II/low grade MCTs sectioned using both radial and tangential sectioning techniques. MATERIALS AND METHODS: A total of 43 circumferential margins were evaluated from 21 different tumours...
May 23, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28543840/imaging-of-nuclear-overhauser-enhancement-at-7-and-3%C3%A2-t
#2
Yuanyu Shen, Gang Xiao, Zhiwei Shen, Xiaolei Zhang, Xiangyong Tang, Wei Hu, Zhiyan Zhang, Jitian Guan, Renhua Wu
Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross-relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation of tumor features. We studied the value of NOE imaging at 7 and 3 T and suggest a utility for diagnosing human brain tumors. Two types of protein solution at different concentrations and pH values, and six normal Sprague Dawley (SD) rats, were used to detect NOE signal with a 7 T scanner. Then, six healthy volunteers and 11 patients with brain tumors (six gliomas and five meningiomas) were included at 3 T...
May 24, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28543360/relationship-between-the-uplc-q-tof-ms-fingerprinted-constituents-from-daphne-genkwa-and-their-anti-inflammatory-anti-oxidant-activities
#3
Wen-Juan Du, Jun Ji, Ling Wang, Xin-Yi Lan, Jia Li, Jun-Qiu Lei, Xin He, Chun-Feng Zhang, Wen-Ze Huang, Zhen-Zhong Wang, Wei Xiao, Chong-Zhi Wang, Chun-Su Yuan
Daphne genkwa Sieb.et Zucc. is a well-known medicinal plant. This study was designed to apply the ultra-high performance liquid chromatography (UPLC) system to establish a quality control method of Daphne genkwa. Data revealed that there were fifteen common peaks in ten batches of D. genkwa Sieb. Et Zucc.(Thymelaeaceae) from different provinces of China. On this basis, the fingerprint chromatogram was established to provide references for quality control. Afterwards, the chemical constitutions of these common peaks were analyzed using the UPLC-Q-TOF-MS system and nine of them were identified primarily...
May 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28543166/chronic-emgs-in-treadmill-running-sod1-mice-reveal-early-changes-in-muscle-activation
#4
K A Quinlan, E Kajtaz, J D Ciolino, R D Imhoff-Manuel, M C Tresch, C J Heckman, V M Tysseling
To improve our understanding of early disease mechanisms and find reliable biomarkers of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease, we measured electromyogram (EMG) activity in hind limb muscles of SOD1G93A mice. In contrast to clinical diagnostic measures using EMGs, which are performed on quiescent patients, we monitored activity during treadmill running in order to detect presymptomatic changes in motor patterning. Chronic EMG electrodes were implanted into vastus lateralis (VL), biceps femoris posterior (BFP), lateral gastrocnemius (LG), and tibialis anterior (TA) in mice from postnatal day (P) 55-100, and results were assessed using linear mixed models...
May 24, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28540942/comparison-of-high-pressure-and-nanoscale-confinement-effects-on-crystallization-of-the-molecular-glass-forming-liquid-dimethyl-phthalate
#5
K Adrjanowicz, G Szklarz, K Koperwas, M Paluch
High pressure and nanoscopic confinement are two different strategies commonly employed to modify the physicochemical properties of various materials. Both strategies act mostly by changing the molecular packing. In this work, we performed a comparative study on the effect of compression and confined geometry on crystallization of a molecular liquid. Dielectric spectroscopy was employed to investigate the crystallization of the van der Waals liquid, dimethyl phthalate, in nanoporous alumina of different pore sizes as well as on increased pressure (up to 200 MPa)...
May 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28540169/establishment-of-a-new-acute-on-chronic-liver-failure-model
#6
Fangfang Li, Luyang Miao, Hua Sun, Yuyang Zhang, Xiuqi Bao, Dan Zhang
To establish an animal model of acute-on-chronic liver failure (ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum (PS) for 11 weeks. Liver fibrosis was determined by pathological and biochemical assessments. The animals then were injected with d-galactosamine (d-gal) and lipopolysaccharide (LPS). The survival times of animals with cirrhosis and ACLF were determined over 48 h. Other animals were killed at 0, 4, 8 and 12 h after administration of d-gal/LPS...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28539748/rapid-development-and-validation-of-improved-reversed-phase-high-performance-liquid-chromatography-method-for-the-quantification-of-mangiferin-a-polyphenol-xanthone-glycoside-in-mangifera-indica
#7
P Naveen, H B Lingaraju, K Shyam Prasad
Mangiferin, a polyphenolic xanthone glycoside from Mangifera indica, is used as traditional medicine for the treatment of numerous diseases. The present study was aimed to develop and validate a reversed-phase high-performance liquid chromatography (RP-HPLC) method for the quantification of mangiferin from the bark extract of M. indica. RP-HPLC analysis was performed by isocratic elution with a low-pressure gradient using 0.1% formic acid: acetonitrile (87:13) as a mobile phase with a flow rate of 1.5 ml/min...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539726/development-and-validation-of-a-simultaneous-rp-hplcuv-dad-method-for-determination-of-polyphenols-in-gels-containing-s-terebinthifolius-raddi-anacardiaceae
#8
Melina G Carvalho, Cícero F S Aragão, Fernanda N Raffin, Túlio F A de L Moura
Topical gels containing extracts of Schinus terebinthifolius have been used to treat bacterial vaginosis. It has been reported that this species has antimicrobial, anti-inflammatory and anti-ulcerogenic properties, which can be attributed to the presence of phenolic compounds. In this work, a sensitive and selective reversed-phase HPLC-UV/DAD method for the simultaneous assay of six polyphenols that could be present in S. terebinthifolius was developed. The method was shown to be accurate and precise. Peak purity and similarity index both exceeded 0...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28538187/bivariate-genomic-footprinting-detects-changes-in-transcription-factor-activity
#9
Songjoon Baek, Ido Goldstein, Gordon L Hager
In response to activating signals, transcription factors (TFs) bind DNA and regulate gene expression. TF binding can be measured by protection of the bound sequence from DNase digestion (i.e., footprint). Here, we report that 80% of TF binding motifs do not show a measurable footprint, partly because of a variable cleavage pattern within the motif sequence. To more faithfully portray the effect of TFs on chromatin, we developed an algorithm that captures two TF-dependent effects on chromatin accessibility: footprinting and motif-flanking accessibility...
May 23, 2017: Cell Reports
https://www.readbyqxmd.com/read/28537484/epidemiological-characterizations-pathogen-spectrum-and-molecular-characteristics-of-coxsackievirus-a16-from-patients-with-hfmd-in-yantai-shandong-china-between-2011-and-2015
#10
Zhenlu Sun, Guifang Zhang, Peijun Guo, Juan Liu, Qiao Gao, Xiaowen Xu, Lianfeng Gong
This study aimed to investigate the epidemiological characterizations and pathogen spectrum of hand, foot, and mouth disease (HFMD) in Yantai City, Shandong Province, China, during 2011-2015, and to study the nucleotide evolution and amino acid variation of coxsackievirus A16 (CV-A16) epidemic strains that caused HFMD. The HFMD epidemic began to rise in March, and became prevalent from May to August, reached its peak in June, and then declined in September every year, children aged one to five years-old had the highest incidence rate whereas the incidence in children under 6 months was very low, and there were more males than females...
May 24, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28537394/3d-double-quantum-double-quantum-exchange-spectroscopy-of-protons-under-100-khz-magic-angle-spinning
#11
Rongchun Zhang, Nghia Tuan Duong, Yusuke Nishiyama, Ayyalusamy Ramamoorthy
Solid-state 1H NMR spectroscopy has attracted much attention in the recent years due to the remarkable spectral resolution improvement by ultrafast magic-angle-spinning (MAS) as well as due to the sensitivity enhancement rendered by proton detection. Although these developments have enabled the investigation of a variety of challenging chemical and biological solids, the proton spectral resolution is still poor for many rigid solid systems owing to the presence of conformational heterogeneity and the unsuppressed residual proton-proton dipolar couplings even with the use of the highest currently feasible sample spinning speed of ~130 kHz...
May 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28537081/high-prevalence-of-brachyspira-spp-in-layers-kept-in-alternative-husbandry-systems-associated-with-frequent-species-variations-from-end-of-rearing-to-slaughter
#12
Claudia Hess, Angelika Zloch, Ivana Bilic, Katrin Hacksteiner, Sabrina Kuchling, Michael Hess
A longitudinal survey was conducted to investigate the presence of Brachyspira species in layer flocks. A total of 66 layer flocks kept in alternative husbandry systems were sampled at three time points: end of rearing, at peak of lay and at end of lay. Content from caecal samples of freshly killed birds was cultured at each sampling time point and processed for further investigations. Gross pathological lesions in caeca were recorded during post mortem investigation. Spirochaetes were isolated from 50 flocks: three flocks were positive at all three sampling points, 25 flocks at two and 22 flocks at one sampling point, respectively...
May 24, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28536868/caffeine-increases-the-velocity-of-rapid-eye-movements-in-unfatigued-humans
#13
Charlotte J W Connell, Benjamin Thompson, Jason Turuwhenua, Robert F Hess, Nicholas Gant
BACKGROUND: Caffeine is a widely used dietary stimulant that can reverse the effects of fatigue on cognitive, motor and oculomotor function. However, few studies have examined the effect of caffeine on the oculomotor system when homeostasis has not been disrupted by physical fatigue. This study examined the influence of a moderate dose of caffeine on oculomotor control and visual perception in participants who were not fatigued. METHODS: Within a placebo-controlled crossover design, 13 healthy adults ingested caffeine (5 mg·kg(-1) body mass) and were tested over 3 h...
May 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28535947/geoepidemiology-clinical-manifestations-and-outcome-of-primary-biliary-cholangitis-in-greece
#14
Nikolaos K Gatselis, Kalliopi Zachou, Vasiliki Lygoura, Kalliopi Azariadis, Pinelopi Arvaniti, Elias Spyrou, Georgia Papadamou, George K Koukoulis, George N Dalekos, Eirini I Rigopoulou
BACKGROUND & AIMS: Primary biliary cholangitis (PBC) is a disease with rising prevalence and considerable geographical variation. To describe the prevalence, spatial and time distribution, baseline characteristics, response to treatment, outcome and the validity of GLOBE score in a large cohort of Greek PBC patients as an independent validation of this score has not been done so far. METHODS: The last 16years, 482 PBC patients (86.5% females) were evaluated and analysed retrospectively, using a prospectively collected database...
May 20, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28535886/fluorescent-nanocellulosic-hydrogels-based-on-graphene-quantum-dots-for-sensing-laccase
#15
Celia Ruiz-Palomero, Sandra Benítez-Martínez, M Laura Soriano, Miguel Valcárcel
A novel low-cost fluorimetric platform based on sulfur, nitrogen-codoped graphene quantum dots immersed into nanocellulosic hydrogels is designed and applied in detecting the laccase enzyme. Although most of methods for detecting laccase are based on their catalytic activity, which is strongly dependent on environmental parameters, we report a sensitive and selective method based on the fluorescence response of hydrogels containing graphene quantum dots (GQDs) acting as luminophore towards laccase. The easily-prepared gel matrix not only improves the fluorescence signal of GQDs by avoiding their self-quenching but also stabilizes their fluorescence signal and improves their sensitivity towards laccase...
June 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28534900/interplay-between-many-body-effects-and-coulomb-screening-in-the-optical-bandgap-of-atomically-thin-mos2
#16
Youngsin Park, Sang Wook Han, Christopher C S Chan, Benjamin P L Reid, Robert A Taylor, Nammee Kim, Yongcheol Jo, Hyunsik Im, Kwang S Kim
Due to its unique layer-number dependent electronic band structure and strong excitonic features, atomically thin MoS2 is an ideal 2D system where intriguing photoexcited-carrier-induced phenomena can be detected in excitonic luminescence. We perform micro-photoluminescence (PL) measurements and observe that the PL peak redshifts nonlinearly in mono- and bi-layer MoS2 as the excitation power is increased. The excited carrier-induced optical bandgap shrinkage is found to be proportional to n(4/3), where n is the optically-induced free carrier density...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28534415/sequence-and-structure-dual-dependent-interaction-between-small-molecules-and-dna-for-the-detection-of-residual-silver-ions-in-as-prepared-silver-nanomaterials
#17
Zhaoyin Wang, Jian Zhao, Zijun Li, Jianchun Bao, Zhihui Dai
Investigations on interaction between small molecules and DNA are the basis of designing advanced bioanalytical systems. We herein propose a novel interaction between heterocyclic aromatic compounds (HACs) and single-stranded DNA (ssDNA). Taking methylene blue (MB) as a typical HAC, it is found that MB can interact with cytosine (C)-rich ssDNA in an enthalpy-driven process. The interaction between MB and C-rich ssDNA is sequence and structure dual-dependent: at least three consecutive C and single-stranded structure are necessary...
May 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28533844/utility-of-first-trimester-obstetric-ultrasonography-before-13-weeks-of-gestation-a-retrospective-study
#18
Felix Uduma Uduma, Anelkan Abaslattai, Dianabasi Udoete Eduwem, Morgan Ekanem, Philip Chinedu Okere
INTRODUCTION: First trimester pregnancy is defined as twelve weeks after the last menstrual period. Ultrasonography has revolutionized validation and management of first trimester pregnancies. The aim was to analyze ultrasonographic findings of first trimester pregnancies in University of Uyo teaching hospital (UUTH), Uyo, Nigeria. METHODS: The departmental ultrasonographic records of pregnant women who were referred to Radiology department of UUTH, Uyo, Nigeria...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28533093/safety-and-immunogenicity-of-a-live-attenuated-influenza-h5-candidate-vaccine-strain-a-17-turkey-turkey-05-133-h5n2-and-its-priming-effects-for-potential-pre-pandemic-use-a-randomised-double-blind-placebo-controlled-trial
#19
Punnee Pitisuttithum, Kobporn Boonnak, Supat Chamnanchanunt, Pilaipan Puthavathana, Viravarn Luvira, Hatairat Lerdsamran, Jaranit Kaewkungwal, Saranath Lawpoolsri, Vipa Thanachartwet, Udomsak Silachamroon, Wanibtisam Masamae, Alexandra Schuetz, Ponthip Wirachwong, Sit Thirapakpoomanunt, Larisa Rudenko, Erin Sparrow, Martin Friede, Marie-Paule Kieny
BACKGROUND: The emergence of highly pathogenic avian influenza H5N1 viruses has raised concerns about their pandemic potential. Vaccination is the most effective way of preventing influenza. In this study, we investigated the safety and immunogenicity of an avian H5N2 live attenuated influenza vaccine (LAIV H5N2) in healthy Thai adults and its priming immune responses with an H5N1 inactivated vaccine boost. METHODS: This study was done at the Vaccine Trial Centre at Mahidol University, Bangkok, Thailand and was divided into two parts...
May 19, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28533029/determination-of-mineral-oil-aromatic-hydrocarbons-moah-in-edible-oils-and-fats-by-online-liquid-chromatography-gas-chromatography-flame-ionization-detection-lc-gc-fid-evaluation-of-automated-removal-strategies-for-biogenic-olefins
#20
Marco Nestola, Torsten C Schmidt
The determination of mineral oil aromatic hydrocarbons (MOAH) in foodstuffs gained in importance over the last years as carcinogenicity cannot be excluded for certain MOAH. The existence of olefins in foodstuffs, such as edible oils and fats, can be problematic for the determination of MOAH by LC-GC-FID. Removal of these interfering substances by HPLC based on polarity differences is not possible. During gas chromatographic separation heavily overloaded peaks are observed rendering the detection of small mineral oil contaminations almost impossible...
May 16, 2017: Journal of Chromatography. A
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