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https://www.readbyqxmd.com/read/27921330/the-new-face-of-isotopic-nmr-at-natural-abundance
#1
Tangi Jézéquel, Valentin Joubert, Patrick Giraudeau, Gérald S Remaud, Serge Akoka
The most widely used method for isotope analysis at natural abundance is isotope ratio monitoring by Mass Spectrometry (irm-MS) which provides bulk isotopic composition in (2) H, (13) C, (15) N, (18) O or (34) S. However, in the 1980s, the direct access to Site-specific Natural Isotope Fractionation by Nuclear Magnetic Resonance (SNIF-NMR(TM) ) was immediately recognized as a powerful technique to authenticate the origin of natural or synthetic products. The initial - and still most popular - application consisted in detecting the chaptalization of wines by irm-(2) H NMR...
November 7, 2016: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/27920895/organosilane-functionalization-of-nanostructured-indium-tin-oxide-films
#2
R Pruna, F Palacio, M Martínez, O Blázquez, S Hernández, B Garrido, M López
Fabrication and organosilane-functionalization and characterization of nanostructured ITO electrodes are reported. Nanostructured ITO electrodes were obtained by electron beam evaporation, and a subsequent annealing treatment was selectively performed to modify their crystalline state. An increase in geometrical surface area in comparison with thin-film electrodes area was observed by atomic force microscopy, implying higher electroactive surface area for nanostructured ITO electrodes and thus higher detection levels...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920473/na-hco3-cotransporter-is-expressed-on-%C3%AE-and-%C3%AE-cells-during-rat-pancreatic-development
#3
Li-Hua Cao, Cheng-Cai Xia, Zhao-Chun Shi, Ning Wang, Zheng-Hua Gu, Li-Zhi Yu, Qi Wan, Wei De
AIM: To determine the expression and localization of the electrogenic Na(+)/HCO3(-) cotransporter (NBC1) in rat pancreas during development. METHODS: The rat pancreas from postnatal and embryos removed from the uterus of pregnant rats that had been sacrificed by CO2 asphyxiation were used. Rat pancreas from embryonic day (E) 15.5 and E18.5 rat embryos was isolated under a stereomicroscope. Rat pancreas from postnatal (P) days 0, 7, 14, 21 and adult was directly isolated by the unaided eye...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27920177/surveillance-for-chikungunya-and-dengue-during-the-first-year-of-chikungunya-virus-circulation-in-puerto-rico
#4
Tyler M Sharp, Kyle R Ryff, Luisa Alvarado, Wun-Ju Shieh, Sherif R Zaki, Harold S Margolis, Brenda Rivera-Garcia
After chikungunya virus (CHIKV) transmission was detected in Puerto Rico in May 2014, multiple surveillance systems were used to describe epidemiologic trends and CHIKV-associated disease. Of 28 327 cases reported via passive surveillance, 6472 were tested for evidence of CHIKV infection, and results for 4399 (68%) were positive. Of 250 participants in household cluster investigations, 70 (28%) had evidence of recent CHIKV infection. Enhanced surveillance for chikungunya at 2 hospitals identified 1566 patients who tested positive for CHIKV, of whom 10...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27919485/the-required-coefficient-of-friction-for-evaluating-gait-alterations-in-people-with-multiple-sclerosis-during-gait
#5
Ilaria Pacifici, Manuela Galli, Ana Francisca Rozin Kleiner, Federica Corona, Giancarlo Coghe, Elisabetta Marongiu, Andrea Loi, Antonio Crisafulli, Eleonora Cocco, Maria Giovanna Marrosu, Massimiliano Pau
BACKGROUND: Required Coefficient of Friction (RCOF) is one of the most critical gait parameters associated to the occurrence of slipping in individuals affected by neurological disorders characterized by balance impairments. This study aims to calculate RCOF in people with Multiple Sclerosis (MS) on the basis of three-dimensional Gait Analysis (GA) data. METHODS: This study enrolls 22 people with MS (pwMS) who were characterized by an Expanded Disability Status Score in the range 1...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919350/identification-and-characterization-of-severe-familial-hypercholesterolemia-in-patients-presenting-for-cardiac-catheterization
#6
Barak Zafrir, Chen Shapira, Gil Lavie, David A Halon, Moshe Y Flugelman
BACKGROUND: Patients with severe familial hypercholesterolemia (FH) are often unrecognized despite typical presentation. The introduction of PCSK9 inhibitors opens new therapeutic options and emphasizes the need for identification of severe FH patients. OBJECTIVES: The objective was identification, characterization, and management of severe FH patients by screening of cardiac catheterization (CC) database. METHODS: Retrospective analysis of CC database from 2002 to mid-2015 was performed for low-density lipoprotein cholesterol (LDL-C) ≥130 mg/dL (n = 2383)...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919101/the-risk-of-pedestrian-collisions-with-peripheral-visual-field-loss
#7
Eli Peli, Henry Apfelbaum, Eliot L Berson, Robert B Goldstein
Patients with peripheral field loss complain of colliding with other pedestrians in open-space environments such as shopping malls. Field expansion devices (e.g., prisms) can create artificial peripheral islands of vision. We investigated the visual angle at which these islands can be most effective for avoiding pedestrian collisions, by modeling the collision risk density as a function of bearing angle of pedestrians relative to the patient. Pedestrians at all possible locations were assumed to be moving in all directions with equal probability within a reasonable range of walking speeds...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27918991/sample-preparation-of-serum-to-allow-capillary-electrophoresis-analysis-of-prostate-specific-antigen-isoforms
#8
Noemi Farina-Gomez, Silvia Barrabes, Jorge E Gomez-Lopez, Monica Gonzalez, Angel Puerta, Diana Navarro-Calderon, Eduardo Albers-Acosta, Carlos Olivier, Jose C Diez-Masa, Rosa Peracaula, Mercedes de Frutos
Prostate cancer is the second most frequently diagnosed cancer in men worldwide. Currently prostate specific antigen (PSA) serum concentration is the most used prostate cancer marker, but it only shows limited specificity. Because PSA glycosylation is altered by prostate cancer, detecting glycosylation changes could increase PSA specificity as a prostate cancer marker. Changes in PSA glycosylation can modify its electrophoretic- behavior and techniques such as capillary zone electrophoresis (CZE) and two-dimensional electrophoresis (2-DE) could be applied to detect changes in PSA glycosylation...
November 24, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27918419/a-theoretical-study-of-love-wave-sensors-based-on-zno-glass-layered-structures-for-application-to-liquid-environments
#9
Cinzia Caliendo, Muhammad Hamidullah
The propagation of surface acoustic Love modes along ZnO/glass-based structures was modeled and analysed with the goal of designing a sensor able to detect changes in the environmental parameters, such as liquid viscosity changes and minute amounts of mass supported in the viscous liquid medium. Love mode propagation was modeled by numerically solving the system of coupled electro-mechanical field equations and Navier-Stokes equations. The phase and group velocities and the attenuation of the acoustic wave propagating along the 30° tilted c-axis ZnO/glass structure contacting a viscous non-conductive liquid were calculated for different ZnO guiding layer thicknesses, added mass thicknesses, and liquid viscosity and density...
December 2, 2016: Biosensors
https://www.readbyqxmd.com/read/27918255/outbreak-of-enterovirus-d68-of-the-new-b3-lineage-in-stockholm-sweden-august-to-september-2016
#10
Robert Dyrdak, Malin Grabbe, Berit Hammas, Jonas Ekwall, Karin E Hansson, Joachim Luthander, Pontus Naucler, Henrik Reinius, Maria Rotzén-Östlund, Jan Albert
We report an enterovirus D68 (EV-D68) outbreak in Stockholm Sweden in 2016. Between 22 August and 25 September EV-D68 was detected in 74/495 respiratory samples analysed at the Karolinska University Hospital. During the peak week, 30/91 (33%) samples were EV-D68 positive. Viral protein (VP)P4/VP2 sequencing revealed that cases were caused by B3 lineage strains. Forty-four (59%) EV-D68-positive patients were children aged ≤ 5 years. Ten patients had severe respiratory or neurological symptoms and one died...
November 17, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27918144/a-novel-rat-tail-discitis-model-using-bioluminescent-staphylococcus-aureus
#11
Phillip A Bostian, Jonathan M Karnes, Shari Cui, Lisa J Robinson, Scott D Daffner, Michelle R Witt, Sanford E Emery
Management of spondylodiscitis is a challenging clinical problem requiring medical and surgical treatment strategies. The purpose of this study was to establish a rat model of spondylodiscitis that utilizes bioluminescent Staphylococcus aureus, thus permitting in-vivo surveillance of infection intensity. Inocula of the bioluminescent S. aureus strain XEN36 were created in concentrations of 10(2) CFU/0.1 mL, 10(4) CFU/0.1 mL, and 10(6) CFU/0.1 mL. Three groups of rats were injected with the bacteria in the most proximal intervertebral tail segment...
December 5, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27917869/neurophysiological-characterization-of-attentional-performance-dysfunction-in-schizophrenia-patients-in-a-reverse-translated-task
#12
Jared W Young, Andrew W Bismark, Yinming Sun, Wendy Zhang, Meghan McIlwain, Ibrahim Grootendorst, Gregory A Light
Attentional dysfunction in schizophrenia (SZ) contributes to the functional deficits ubiquitous to the disorder. Identifying the neural substrates of translational measures of attentional dysfunction would prove invaluable for developing therapeutics. Attentional performance is typically assessed via continuous performance tasks (CPTs), though many place additional cognitive demands with little cross-species test-relevance. Herein, event related potentials (ERPs) were utilized to investigate the neurophysiological correlates of attention and response inhibition of SZ and healthy participants, while they performed the cross-species translated five-choice CPT (5C-CPT)...
December 5, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27917463/decision-making-regarding-mammography-screening-for-older-women
#13
Mara A Schonberg
The population is aging, and breast cancer incidence increases with age, peaking between the ages of 75 and 79. However, it is not known whether mammography screening helps women aged 75 and older live longer because they have not been included in randomized controlled trials evaluating mammography screening. Guidelines recommend that older women with less than a 10-year life expectancy not be screened because it takes approximately 10 years before a screen-detected breast cancer may affect an older woman's survival...
December 5, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27916920/dielectrically-loaded-cylindrical-resonator-based-wireless-passive-high-temperature-sensor
#14
Jijun Xiong, Guozhu Wu, Qiulin Tan, Tanyong Wei, Dezhi Wu, Sanmin Shen, Helei Dong, Wendong Zhang
The temperature sensor presented in this paper is based on a microwave dielectric resonator, which uses alumina ceramic as a substrate to survive in harsh environments. The resonant frequency of the resonator is determined by the relative permittivity of the alumina ceramic, which monotonically changes with temperature. A rectangular aperture etched on the surface of the resonator works as both an incentive and a coupling device. A broadband slot antenna fed by a coplanar waveguide is utilized as an interrogation antenna to wirelessly detect the sensor signal using a radio-frequency backscattering technique...
December 1, 2016: Sensors
https://www.readbyqxmd.com/read/27916716/effects-of-a-non-competitive-n-methyl-d-aspartate-nmda-antagonist-tiletamine-in-adult-zebrafish
#15
Tatiana O Kolesnikova, Sergey L Khatsko, Vadim A Shevyrin, Yuri Yu Morzherin, Allan V Kalueff
Tiletamine is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist chemically related to ketamine and phencyclidine. A common veterinary anesthetic drug, tiletamine is currently a Schedule III controlled substance. This compound exerts sedative effects in humans and animals, also having an abuse potential, toxicity and dissociative hallucinogenic properties clinically. However, the neurotropic profile of tiletamine remains poorly understood, necessitating novel models and in-vivo screens, including non-mammalian species...
December 1, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27916346/cardiopulmonary-exercise-testing-is-a-better-outcome-predictor-than-exercise-echocardiography-in-asymptomatic-aortic-stenosis
#16
Olivia Domanski, Marjorie Richardson, Augustin Coisne, Anne-Sophie Polge, Stephanie Mouton, François Godart, Jean Louis Edmé, Regis Matran, Patrizio Lancellotti, David Montaigne
BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship between peak VO2 and AS severity criteria derived from rest and supine exercise echocardiography (SEE) has never been explored. OBJECTIVES: We aimed to determine whether low peak VO2 (<85% of predicted value) is associated with severity parameters in SEE, and poor clinical outcome...
November 3, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27916264/the-use-of-conifer-needles-as-biomonitor-candidates-for-the-study-of-temporal-air-pollution-variation-in-the-strasbourg-region
#17
Josephine Al-Alam, Ziad Fajloun, Asma Chbani, Maurice Millet
The continuous emission of polluting chemicals into the atmosphere requires the implementation of monitoring of ambient air quality. The use of vegetation for environmental monitoring can be considered as a simple monitoring technique by providing a cheap and accessible matrix. In this study, needles of two conifers (Pinus nigra and Cedrus atlantica), were used for the consecutive biomonitoring of multipollutants such as pesticides, polychlorinated biphenyls, and polyaromatic hydrocarbons (PAHs) in an urban area in Strasbourg (France)...
December 1, 2016: Chemosphere
https://www.readbyqxmd.com/read/27916236/strain-imaging-with-a-bull-s-eye-map-for-detecting-significant-coronary-stenosis-during-dobutamine-stress-echocardiography
#18
Li-Tan Yang, Yuichiro Kado, Yasufumi Nagata, Kyoko Otani, Yutaka Otsuji, Masaaki Takeuchi
BACKGROUND: Accurate visual assessment of wall motion during dobutamine stress echocardiography (DSE) requires expertise; strain stress echocardiography thus has potential for the objective and reliable evaluation of stress-induced wall motion abnormalities. The aim of this study was to test the hypothesis that strain imaging also requires expertise. Diagnostic accuracy for significant coronary artery disease was compared between visual and strain analysis with a bull's-eye map, and the effect of expertise on readers' accuracy during DSE was determined...
December 1, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27916128/a-paper-based-platform-with-a-pencil-drawn-dual-amperometric-detector-for-the-rapid-quantification-of-ortho-diphenols-in-extravirgin-olive-oil
#19
Nicolò Dossi, Rosanna Toniolo, Flavia Impellizzieri, Franco Tubaro, Gino Bontempelli, Fabio Terzi, Evandro Piccin
A simple, sensitive and fast responding device is described for the discrimination of hydrophilic ortho-diphenols, whose presence in abundant enough amounts is typical for extra virgin olive oils (EVOOs), from hydrophilic mono-phenols instead present in almost all vegetable oils. It consists of a dual electrode detector pencil-drawn at the end of a paper microfluidic channel, defined by hydrophobic barriers, where samples of these antioxidants, extracted from vegetable oils by a 80:20% v/v acetonitrile/water mixture, were applied...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27915454/round-fruit-shape-in-wi7239-cucumber-is-controlled-by-two-interacting-quantitative-trait-loci-with-one-putatively-encoding-a-tomato-sun-homolog
#20
Yupeng Pan, Xinjing Liang, Meiling Gao, Hanqiang Liu, Huanwen Meng, Yiqun Weng, Zhihui Cheng
QTL analysis revealed two interacting loci, FS1.2 and FS2.1, underlying round fruit shape in WI7239 cucumber; CsSUN , a homolog of tomato fruit shape gene SUN , was a candidate for FS1.2. Fruit size is an important quality and yield trait in cucumber, but its genetic basis remains poorly understood. Here we reported QTL mapping results on fruit size with segregating populations derived from the cross between WI7238 (long fruit) and WI7239 (round fruit) inbred cucumber lines. Phenotypic data of fruit length and diameter were collected at anthesis, immature and mature fruit stages in four environments...
December 3, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
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