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https://www.readbyqxmd.com/read/28817226/the-stochastic-resonance-algorithm-with-the-direct-current-signal-as-external-force-and-its-application-to-the-detection-of-weak-chromatographic-peaks
#1
Rui Li, Bingren Xiang, Haishan Deng, Shaofei Xie
As a potential tool for amplifying weak chromatographic peaks, the stochastic resonance algorithm was developed based upon a counterintuitive physical phenomenon. Therefore, the essential step, parameter optimization, was perplexing and difficult for analysts. In order to avoid optimizing the system parameters on a case-by-case basis, an improved algorithm was proposed by introducing a constant or direct current signal into the signal to be measured as the external force. The weak chromatographic peak can be amplified and detected by the new algorithm using the same set of parameters...
August 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28816534/seven-familial-dysalbuminemic-hyperthyroxinemia-cases-in-three-unrelated-japanese-families-and-high-performance-liquid-chromatography-analysis-of-the-thyroxine-binding-profile
#2
Hidekazu Nagano, Yoshinori Nakagawa, Naofumi Ishikawa, Yuya Watanabe, Yui Miyabayashi, Akitoshi Nakayama, Masanori Fujimoto, Eri Komai, Akina Shiga, Ai Tamura, Takashi Kono, Tomoko Takiguchi, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Hisashi Koide, Kotaro Yokote, Tomoaki Tanaka
OBJECTIVE: Familial dysalbuminemic hyperthyroxinemia (FDH) is caused by abnormal human serum albumin (HSA) with an increased thyroxine (T4) affinity leading to euthyroid hyperthyroxinemia. One- and two-step immunoassay of serum samples from FDH patients (e.g., Japanese patients) with the HSA R218P mutation can yield false-positive free thyroxine (FT4) results. Therefore, it is difficult to distinguish FDH from syndrome of inappropriate secretion of thyroid-stimulating hormone (e.g., syndrome of resistance to thyroid hormone, thyroid-stimulating hormone [TSH]-producing pituitary adenoma), even when multiple assays are used...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28816526/echocardiographic-assessment-of-right-ventricle-dimensions-and-function-after-exposure-to-extreme-altitude-is-an-expedition-to-8000%C3%A2-m-hazardous-for-right-ventricular-function
#3
Marta Kurdziel, Jarosław Wasilewski, Karolina Gierszewska, Anna Kazik, Gracjan Pytel, Jacek Wacławski, Adam Krajewski, Anna Kurek, Lech Poloński, Mariusz Gąsior
Kurdziel, Marta, Jarosław Wasilewski, Karolina Gierszewska, Anna Kazik, Gracjan Pytel, Jacek Wacławski, Adam Krajewski, Anna Kurek, Lech Poloński, and Mariusz Gąsior. Echocardiographic assessment of right ventricle dimensions and function after exposure to extreme altitude: Is an expedition to 8000 m hazardous for right ventricular function? High Alt Med Biol 00:000-000, 2017.-Although the right ventricle (RV) is under great hypoxic stress at altitude, still little is known what happens to the RV after descent...
August 17, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28816397/a-flow-through-column-electrolytic-cell-for-supercritical-fluid-chromatography
#4
Kazuhiro Yamamoto, Tatsuya Ueki, Naoyuki Higuchi, Kouji Takahashi, Akira Kotani, Hideki Hakamata
A novel flow-through column electrolytic cell was proposed as a detector to obtain current signals for supercritical fluid chromatography. The electrochemical cell consisted of two electrodes and its holder, and a working and a counter electrode were fabricated from 192 carbon strings, which were composed of 400 carbon fibers of 10 μm in diameter filled into a heat-shrinkable tube. These electrodes were placed in the center of a holder made from polyether ether ketone blocks and they were separated by polytetrafluoroethylene membrane filters...
August 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28816145/strain-imaging-detects-dose-dependent-segmental-cardiac-dysfunction-in-the-acute-phase-after-breast-irradiation
#5
Queenie Lo, Leia Hee, Vikneswary Batumalai, Christine Allman, Peter MacDonald, Denise Lonergan, Geoff P Delaney, Liza Thomas
PURPOSE: We examined the utility of echocardiographic 2-dimensional speckle tracking strain imaging (SI) for the evaluation of segmental myocardial dysfunction before and after radiation therapy (RT) and the relationship to dose exposure. METHODS AND MATERIALS: We prospectively recruited 40 women with left-sided breast cancer, undergoing only adjuvant RT to the left chest. Comparisons of traditional echocardiographic parameters and SI parameters at baseline and 6 weeks after RT were analyzed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815397/detecting-and-accounting-for-multiple-sources-of-positional-variance-in-peak-list-registration-analysis-and-spin-system-grouping
#6
Andrey Smelter, Eric C Rouchka, Hunter N B Moseley
Peak lists derived from nuclear magnetic resonance (NMR) spectra are commonly used as input data for a variety of computer assisted and automated analyses. These include automated protein resonance assignment and protein structure calculation software tools. Prior to these analyses, peak lists must be aligned to each other and sets of related peaks must be grouped based on common chemical shift dimensions. Even when programs can perform peak grouping, they require the user to provide uniform match tolerances or use default values...
August 16, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28815272/gold-nanoparticle-based-localized-surface-plasmon-immunosensor-for-staphylococcal-enterotoxin-a-sea-detection
#7
Maroua Ben Haddada, David Hu, Michèle Salmain, Lu Zhang, Chen Peng, Yi Wang, Bo Liedberg, Souhir Boujday
We describe the engineering of stable gold nanoparticle (AuNP) bioconjugates for the detection of staphylococcal enterotoxin A (SEA) using localized surface plasmon resonance (LSPR). Two types of AuNP bioconjugates were prepared by covalently attaching anti-SEA antibody (Ab) or SEA to AuNPs. This was achieved by reacting Traut's reagent with lysine residues of both proteins to generate thiol groups that bind to gold atoms on the AuNP surface. These bioconjugates were characterized in-depth by absorption spectroscopy, cryo-transmission electron microscopy, dynamic light scattering, and zeta potential measurements...
August 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28814850/increased-parasympathetic-cardiac-modulation-in-patients-with-acute-exacerbation-of-copd-how-should-we-interpret-it
#8
Erika Zavaglia Kabbach, Adriana Mazzuco, Audrey Borghi-Silva, Ramona Cabiddu, Aline Galvão Agnoleto, Jessica Fernanda Barbosa, Luiz Carlos Soares de Carvalho Junior, Renata Gonçalves Mendes
BACKGROUND: Cardiac autonomic modulation (CAM) is impaired in patients with stable COPD. Exacerbation aggravates the patients' health status and functional capacity. While the clinical and functional effects of exacerbation are known, no studies investigated CAM during exacerbation and whether there is a relationship between CAM and functional capacity and dyspnea. METHODS: Thirty-two patients with moderate to severe COPD were enrolled into two groups: stable COPD (GSta, n=16) and acute exacerbation of COPD (GAE, n=16)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28814124/comparative-metabolic-profiling-of-costus-speciosus-leaves-and-rhizomes-using-nmr-gc-ms-and-uplc-esi-ms-ms
#9
Ashish Kumar, Antim K Maurya, Gopi Chand, Vijai K Agnihotri
Costus speciosus had been used in oriental systems of medicines, to treat diverse ailments. The present study was focused on NMR, GC-MS and UPLC/ESI-MS/MS-based metabolic profiling of C. speciosus. This metabolic study resulted in the identification of 91 and quantification of 69 metabolites. Caffeic acid derivatives previously unreported in C. speciosus were also identified. High quantity of steroidal saponins namely methyl protogracillin (297.97 ± 0.07 mg/g dried wt.) and dioscin (158.72 ± 0.27 mg/g dried wt...
August 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28813416/large-turbulent-reservoirs-of-cold-molecular-gas-around-high-redshift-starburst-galaxies
#10
E Falgarone, M A Zwaan, B Godard, E Bergin, R J Ivison, P M Andreani, F Bournaud, R S Bussmann, D Elbaz, A Omont, I Oteo, F Walter
Starburst galaxies at the peak of cosmic star formation are among the most extreme star-forming engines in the Universe, producing stars over about 100 million years (ref. 2). The star-formation rates of these galaxies, which exceed 100 solar masses per year, require large reservoirs of cold molecular gas to be delivered to their cores, despite strong feedback from stars or active galactic nuclei. Consequently, starburst galaxies are ideal for studying the interplay between this feedback and the growth of a galaxy...
August 14, 2017: Nature
https://www.readbyqxmd.com/read/28812356/single-molecule-nanopore-spectrometry-for-peptide-detection
#11
Amy E Chavis, Kyle T Brady, Grace A Hatmaker, Christopher E Angevine, Nuwan Kothalawala, Amala Dass, Joseph W F Robertson, Joseph E Reiner
Sensing and characterization of water-soluble peptides is of critical importance in a wide variety of bioapplications. Single molecule nanopore spectrometry (SMNS) is based on the idea that one can use biological protein nanopores to resolve different sized molecules down to limits set by the blockade duration and noise. Previous work has shown that this enables discrimination between polyethylene glycol (PEG) molecules that differ by a single monomer unit. This paper describes efforts to extend SMNS to a variety of biologically relevant, water-soluble peptides...
August 16, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28812108/ultra-early-detection-of-microcirculatory-injury-as-predictor-of-developing-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#12
Philipp Gölitz, Philip Hoelter, Julie Rösch, Karl Roessler, Frauke Knossalla, Arnd Doerfler
PURPOSE: Delayed cerebral ischemia (DCI) still remains a major complication after subarachnoid hemorrhage (SAH). The aim of our study was to evaluate whether flow analysis of admission digital subtraction angiography (DSA) using parametric color coding (PCC), a postprocessing algorithm, allows ultra-early identification of SAH patients at risk for developing subsequent symptomatic vasospasm. METHODS: In this study 52 patients who suffered SAH from aneurysm rupture, were retrospectively enrolled...
August 15, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28811657/colorimetric-fingerprints-of-gold-nanorods-for-discriminating-catecholamine-neurotransmitters-in-urine-samples
#13
Somayeh Jafarinejad, Mahmoud Ghazi-Khansari, Forough Ghasemi, Pezhman Sasanpour, M Reza Hormozi-Nezhad
Catecholamine neurotransmitters, generally including dopamine (DA), epinephrine (EP) and norepinephrine (NE) are known as substantial indicators of various neurological diseases. Simultaneous detection of these compounds and their metabolites is highly recommended in early clinical diagnosis. To this aim, in the present contribution, a high performance colorimetric sensor array has been proposed for the detection and discrimination of catecholamines based on their reducing ability to deposit silver on the surface of gold nanorods (AuNRs)...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811555/identification-of-novel-micrornas-in-the-sheep-heart-and-their-regulation-in-heart-failure
#14
Lee Lee Wong, Miriam T Rademaker, Eng Leng Saw, Kar Sheng Lew, Leigh J Ellmers, Christopher J Charles, Arthur Mark Richards, Peipei Wang
Study of microRNA (miRNAs) using sheep models is limited due to lack of miRNA information. We therefore investigated oar-miRNAs and their regulation in an ovine model of heart failure (HF). Left ventricular (LV) tissue was collected from normal (Cont), HF (LV pacing @ ~220bpm for 13-days) and HF-recovery sheep (HF-R, 26-days after pacing cessation). MiRNA expression was profiled using next-generation sequencing (NGS) and miRNA array, and validated by stem-loop qPCR. Detected sequences were mapped against the ovine genome (Oar v4...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811087/real-time-qrt-pcr-assay-for-the-detection-of-mirnas-using-bi-directional-extension-sequences
#15
Kyung Jin Kim, Jiwon Kwak, Jae-Hoon Lee, Soo Suk Lee
Highly specific detection of miRNAs was performed using a novel bi-directional extension (BDE) assay. After reverse transcription, the cDNA was hybridized to a uniquely designed specific BDE sequence; this cDNA-BDE hybrid forms the PCR template. The PCR template was amplified in a SYBR Green-based quantitative real-time PCR. The miR-145 in human brain total RNA could be detected quantitatively in the range of seven orders of magnitude with high linearity and reproducibility. This innovative BDE assay has several performance advantages over the poly(A) tailing method that include lower CT values, clear gel electrophoresis images, and distinct nucleotide peaks in sequencing chromatograms...
August 12, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28811031/bayesian-approach-to-peak-deconvolution-and-library-search-for-high-resolution-gas-chromatography-mass-spectrometry
#16
A Barcaru, H G J Mol, M Tienstra, G Vivó-Truyols
A novel probabilistic Bayesian strategy is proposed to resolve highly coeluting peaks in high-resolution GC-MS (Orbitrap) data. Opposed to a deterministic approach, we propose to solve the problem probabilistically, using a complete pipeline. First, the retention time(s) for a (probabilistic) number of compounds for each mass channel are estimated. The statistical dependency between m/z channels was implied by including penalties in the model objective function. Second, Bayesian Information Criterion (BIC) is used as Occam's razor for the probabilistic assessment of the number of components...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28810948/development-and-validation-of-a-robust-and-efficient-hplc-method-for-the-simultaneous-quantification-of-levodopa-carbidopa-benserazide-and-entacapone-in-complex-matrices
#17
Erik Wollmer, Sandra Klein
PURPOSE: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available. The objective of the present work was thus to develop and validate an analytical method for the simultaneous quantification of levodopa, carbidopa, benserazide and entacapone. The method should be applicable for quantifying samples from drug release experiments with marketed products and prototype formulations performed under compendial and biorelevant test conditions...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28810731/the-impact-of-hydrogen-bonding-on-the-dynamics-and-structure-of-protic-ionic-liquid-water-binary-mixtures
#18
Heather E Bailey, Yong-Lei Wang, Michael D Fayer
The orientational dynamics and microscopic liquid structure of a protic ionic liquid, 1-ethylimidazolium bis(trifluoromethylsulfonyl)imide (EhimNTf2), and its aprotic analogue, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EmimNTf2), were studied at various water concentrations using optical heterodyne-detected optical Kerr Effect (OHD-OKE) spectroscopy, linear infrared spectroscopy, and atomistic simulations. The OHD-OKE experiments essentially measure the orientational relaxation of the Ehim+ and Emim+ cations...
August 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28809925/salivary-peptidome-profiling-analysis-for-occurrence-of-new-carious-lesions-in-patients-with-severe-early-childhood-caries
#19
Chang Tian, Xiangyu Sun, Xiaochen Liu, Xin Huang, Feng Chen, Shuguo Zheng
This study aimed to identify differences of peptide profiles in stimulated whole saliva among children with and without occurrence of new carious lesions, and to provide a simple way for early diagnosis and prevention of the relapse of severe early childhood caries (s-ECC). Overall, 26 children aged 3-4 years were selected out from all the children in the kindergarten to be involved in the present study, among them 13 were diagnosed as s-ECC and underwent dental treatment, whilst the other 13 were matched by age and sex as control...
2017: PloS One
https://www.readbyqxmd.com/read/28808955/exploring-the-biological-and-mechanical-properties-of-abdominal-aortic-aneurysms-using-uspio-mri-and-peak-tissue-stress-a-combined-clinical-and-finite-element-study
#20
Noel Conlisk, Rachael O Forsythe, Lyam Hollis, Barry J Doyle, Olivia M B McBride, Jennifer M J Robson, Chengjia Wang, Calum D Gray, Scott I K Semple, Tom MacGillivray, Edwin J R van Beek, David E Newby, Peter R Hoskins
Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm...
August 14, 2017: Journal of Cardiovascular Translational Research
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