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https://www.readbyqxmd.com/read/29135952/integrated-pest-management-of-coffee-berry-borer-in-hawaii-and-puerto-rico-current-status-and-prospects
#1
Luis F Aristizábal, Melissa Johnson, Suzanne Shriner, Robert Hollingsworth, Nicholas C Manoukis, Roxana Myers, Paul Bayman, Steven P Arthurs
The coffee berry borer (CBB), Hypothenemus hampei, is the most significant insect pest of coffee worldwide. Since CBB was detected in Puerto Rico in 2007 and Hawaii in 2010, coffee growers from these islands are facing increased costs, reduced coffee quality, and increased pest management challenges. Here, we outline the CBB situation, and summarize the findings of growers, researchers, and extension professionals working with CBB in Hawaii. Recommendations for the Integrated Pest Management (IPM) program for CBB in Hawaiian Islands and Puerto Rico include: (1) establish a CBB monitoring program, (2) synchronize applications of insecticides with peak flight activity of CBB especially during the early coffee season, (3) conduct efficient strip-picking as soon as possible after harvest and perform pre-harvest sanitation picks in CBB hotspots if needed, (4) establish protocols to prevent the escape of CBB from processing areas and when transporting berries during harvest, and (5) stump prune by blocks...
November 14, 2017: Insects
https://www.readbyqxmd.com/read/29079454/the-adenosine-a2a-receptor-agonist-t1-11-ameliorates-neurovisceral-symptoms-and-extends-the-lifespan-of-a-mouse-model-of-niemann-pick-type-c-disease
#2
Antonella Ferrante, Antonella Pezzola, Andrea Matteucci, Antonella Di Biase, Lucilla Attorri, Monica Armida, Alberto Martire, Yijuang Chern, Patrizia Popoli
Niemann-Pick C is a fatal neurovisceral disorder caused, in 95% of cases, by mutation of NPC1 gene. Therapeutic options are extremely limited and new "druggable" targets are highly warranted. We previously demonstrated that the stimulation of the adenosine A2A receptor (A2AR) normalized the pathological phenotype of cellular models of NPC1. Since the validation of A2ARs as a therapeutic target for NPC1 can be obtained only conducting studies in in vivo models of the disease, in the present paper, the effects of two agonists of A2ARs were evaluated in the mouse model Balb/c Npc1(nih), hereafter indicated as NPC1-/-...
October 25, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29043470/comprehensive-analysis-of-nmr-data-using-advanced-line-shape-fitting
#3
Markus Niklasson, Renee Otten, Alexandra Ahlner, Cecilia Andresen, Judith Schlagnitweit, Katja Petzold, Patrik Lundström
NMR spectroscopy is uniquely suited for atomic resolution studies of biomolecules such as proteins, nucleic acids and metabolites, since detailed information on structure and dynamics are encoded in positions and line shapes of peaks in NMR spectra. Unfortunately, accurate determination of these parameters is often complicated and time consuming, in part due to the need for different software at the various analysis steps and for validating the results. Here, we present an integrated, cross-platform and open-source software that is significantly more versatile than the typical line shape fitting application...
October 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29039932/annotation-a-computational-solution-for-streamlining-metabolomics-analysis
#4
Xavier Domingo-Almenara, J Rafael Montenegro-Burke, H Paul Benton, Gary Siuzdak
The aim of any untargeted metabolomics experiment is to identify and quantify dysregulated compounds relevant to a particular disease or stressor. However, metabolite identification is still considered an imposing bottleneck in untargeted metabolomics. Untargeted data analysis workflows for liquid chromatography/electrospray ionization/mass spectrometry (LC/ESI/MS) usually consist in applying peak-picking algorithms, align those peaks across multiple samples to obtain the so-called peak features (defined as a peak, or a set of aligned peaks across samples with a unique \textit{m/z} and a specific retention time), and subsequently discover statistically significant variations between experimental groups or conditions...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29023073/reproductive-biology-of-sardinella-sp-sardinella-aurita-and-sardinella-maderensis-in-the-south-of-morocco
#5
Ayoub Baali, Hajar Bourassi, Samira Falah, Wahbi Abderrazik, Khalid Manchih, Khadija Amenzoui, Ahmed Yahyaoui
BACKGROUND AND OBJECTIVE: Sardinella sp. has gained much attention lately because of its biomass increase, which might be the result of climatic changes occurring across the Atlantic sea. Little information is known about reproduction of these species particularly in the Moroccan Atlantic area. The objective of the this study was to explore some aspects of the reproductive biology of Sardinella in the South of Atlantic Moroccan coast. MATERIALS AND METHODS: Monthly samples were collected during the period between February, 2015 and January, 2016 in the area between Cape Boujdor and Cape Blanc...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28977750/data-independent-mass-spectrometry-approach-for-screening-and-identification-of-dna-adducts
#6
Jingshu Guo, Peter W Villalta, Robert J Turesky
Long-term exposures to environmental toxicants and endogenous electrophiles are causative factors for human diseases including cancer. DNA adducts reflect the internal exposure to genotoxicants and can serve as biomarkers for risk assessment. Liquid chromatography-multistage mass spectrometry (LC-MS(n)) is the most common method for biomonitoring DNA adducts, generally targeting single exposures and measuring up to several adducts. However, the data often provide limited evidence for a role of a chemical in the etiology of cancer...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926221/fourier-transform-ms-and-closed-path-multireflection-time-of-flight-ms-using-an-electrostatic-linear-ion-trap
#7
Eric T Dziekonski, Joshua T Johnson, Kenneth W Lee, Scott A McLuckey
An electrostatic linear ion trap (ELIT) has been configured to allow for the simultaneous acquisition of mass spectra via Fourier transform (FT) techniques (frequency measurement) and via time-of-flight (TOF; time measurement). In the former case, the time-domain image charge derived from a pick-up electrode in the field-free region of the ELIT is converted to frequency-domain data via Fourier transformation (i.e., FT-ELIT MS). In the latter case, the time difference between ion injection into the ELIT and ion detection after release from the ELIT using a microchannel plate (MCP) enables the acquisition of multireflection time-of-flight mass spectra (MR-TOF MS)...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28890673/navigating-freely-available-software-tools-for-metabolomics-analysis
#8
REVIEW
Rachel Spicer, Reza M Salek, Pablo Moreno, Daniel Cañueto, Christoph Steinbeck
INTRODUCTION: The field of metabolomics has expanded greatly over the past two decades, both as an experimental science with applications in many areas, as well as in regards to data standards and bioinformatics software tools. The diversity of experimental designs and instrumental technologies used for metabolomics has led to the need for distinct data analysis methods and the development of many software tools. OBJECTIVES: To compile a comprehensive list of the most widely used freely available software and tools that are used primarily in metabolomics...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28862997/a-novel-optically-transparent-rf-shielding-for-fully-integrated-pet-mri-systems
#9
C Parl, A Kolb, A M Schmid, H F Wehrl, J A Disselhorst, P D Soubiran, D Stricker-Shaver, B J Pichler
Preclinical imaging benefits from simultaneous acquisition of high-resolution anatomical and molecular data. Additionally, PET/MRI systems can provide functional PET and functional MRI data. To optimize PET sensitivity, we propose a system design that fully integrates the MRI coil into the PET system. This allows positioning the scintillators near the object but requires an optimized design of the MRI coil and PET detector. It further requires a new approach in realizing the radiofrequency (RF) shielding. Thus, we propose the use of an optically transparent RF shielding material between the PET scintillator and the light sensor, suppressing the interference between both systems...
September 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28843027/lc-ms-smrm-method-development-and-validation-of-different-classes-of-pain-panel-drugs-and-analysis-of-clinical-urine-samples
#10
M Athar Masood, Timothy D Veenstra
Urine Drug Testing (UDT) is an important analytical/bio-analytical technique that has inevitably become an integral and vital part of a testing program for diagnostic purposes. This manuscript presents a tailor-made LC-MS/MS quantitative assay method development and validation for a custom group of 33 pain panel drugs and their metabolites belonging to different classes (opiates, opioids, benzodiazepines, illicit, amphetamines, etc.) that are prescribed in pain management and depressant therapies. The LC-MS/MS method incorporates two experiments to enhance the sensitivity of the assay and has a run time of about 7 min...
August 26, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28833398/assessment-of-time-to-glucose-peak-during-an-oral-glucose-tolerance-test
#11
LETTER
Adam Hulman, Daniel R Witte, Dorte Vistisen, Kristine Faerch
No abstract text is available yet for this article.
August 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28830233/investigating-and-analyzing-three-cohorts-of-mushroom-poisoning-caused-by-amanita-exitialis-in-yunnan-china
#12
J Sun, H-J Li, H-S Zhang, Y-Z Zhang, J-W Xie, P-B Ma, C Guo, C Y Sun
Amanita exitialis is a lethal mushroom found in China. Knowledge regarding taxonomic characterization, toxin detection, general poisoning conditions, clinical manifestations, laboratory examinations, and clinical treatments for this species is currently lacking. We investigated three A. exitialis mushroom poisoning cohorts in Yunnan Province in 2014 and 2015, involving 10 patients. Mushroom samples were identified by morphological and molecular studies. Ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry was used to detect the peptide toxins in the mushroom samples...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28783153/pecan-library-free-peptide-detection-for-data-independent-acquisition-tandem-mass-spectrometry-data
#13
Ying S Ting, Jarrett D Egertson, James G Bollinger, Brian C Searle, Samuel H Payne, William Stafford Noble, Michael J MacCoss
Data-independent acquisition (DIA) is an emerging mass spectrometry (MS)-based technique for unbiased and reproducible measurement of protein mixtures. DIA tandem mass spectrometry spectra are often highly multiplexed, containing product ions from multiple cofragmenting precursors. Detecting peptides directly from DIA data is therefore challenging; most DIA data analyses require spectral libraries. Here we present PECAN (http://pecan.maccosslab.org), a library-free, peptide-centric tool that robustly and accurately detects peptides directly from DIA data...
September 2017: Nature Methods
https://www.readbyqxmd.com/read/28783002/non-targeted-workflow-for-identification-of-antimicrobial-compounds-in-animal-feed-using-bioassay-directed-screening-in-combination-with-liquid-chromatography-high-resolution-mass-spectrometry
#14
Robin S Wegh, Bjorn J A Berendsen, Wilma D M Driessen-Van Lankveld, Mariël G Pikkemaat, Tina Zuidema, Leen A Van Ginkel
A non-targeted workflow is reported for the isolation and identification of antimicrobial active compounds using bioassay-directed screening and LC coupled to high-resolution MS. Suspect samples are extracted using a generic protocol and fractionated using two different LC conditions (A and B). The behaviour of the bioactive compound under these different conditions yields information about the physicochemical properties of the compound and introduces variations in co-eluting compounds in the fractions, which is essential for peak picking and identification...
November 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28753686/understanding-individual-differences-in-color-appearance-of-thedress-based-on-the-optimal-color-hypothesis
#15
Keiji Uchikawa, Takuma Morimoto, Tomohisa Matsumoto
We performed a theoretical analysis based on our optimal color hypothesis to explain why "#TheDress" image had a different color appearance for different observers (observer-dependent perception). We then carried out an experiment to test the hypothesis derived from the aforementioned theoretical analysis. In the optimal color hypothesis, the visual system picks the optimal color distribution that provides the best fit to the luminance distribution at a scene. The peak of the best-fit optimal color distribution corresponds with the illuminant's color temperature...
July 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28752757/detailed-investigation-and-comparison-of-the-xcms-and-mzmine-2-chromatogram-construction-and-chromatographic-peak-detection-methods-for-preprocessing-mass-spectrometry-metabolomics-data
#16
Owen D Myers, Susan J Sumner, Shuzhao Li, Stephen Barnes, Xiuxia Du
XCMS and MZmine 2 are two widely used software packages for preprocessing untargeted LC/MS metabolomics data. Both construct extracted ion chromatograms (EICs) and detect peaks from the EICs, the first two steps in the data preprocessing workflow. While both packages have performed admirably in peak picking, they also detect a problematic number of false positive EIC peaks and can also fail to detect real EIC peaks. The former and latter translate downstream into spurious and missing compounds and present significant limitations with most existing software packages that preprocess untargeted mass spectrometry metabolomics data...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28703318/ft-artifacts-and-power-function-resolution-filter-in-fourier-transform-mass-spectrometry
#17
Basem Kanawati, Theresa Bader, Karl-Peter Wanczek, Yan Li, Philippe Schmitt-Kopplin
RATIONALE: Peak picking algorithms in mass spectrometry face the challenge of picking the correct signals from a mass spectrum. In some cases signal wiggles (side lobes) are also chosen in the produced mass list as if they were real signals. Constraints which are defined in such algorithms do not always guarantee wiggle free accurate mass list generation out of raw mass spectra. This problem intensifies with acquisitions, which are accompanied with longer transients. Thus, the problem represents a contemporary issue, which propagates with modern high memory digitizers and exists in both MS and MS/MS spectra...
July 13, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28622319/flicker-electroretinograms-recorded-with-mydriasis-free-reteval-system-before-and-after-cataract-surgery
#18
G Miura, E Sato, S Yamamoto
PurposeThe purpose of this study is to compare the amplitudes and peak times of the flicker electroretinograms (ERGs) recorded before and after cataract surgery with the RETeval system (LKC Technologies, Gaithersburg, MD, USA) from eyes without dilation.Patients and methodsThirty-two eyes of 32 patients (77.3±6.5 years) that had grade 2 Emery-Little nuclear or cortical cataract without any other abnormalities were studied. Flicker ERGs were recorded with the RETeval system under mydriatic-free conditions. Skin electrodes were used to pick-up the ERGs that were elicited by white light delivered at a rate of 28...
November 2017: Eye
https://www.readbyqxmd.com/read/28542374/targeted-box-and-blocks-test-normative-data-and-comparison-to-standard-tests
#19
Kimberly Kontson, Ian Marcus, Barbara Myklebust, Eugene Civillico
BACKGROUND: The Box and Block Test (BBT) is a functional outcome measure that is commonly used across multiple clinical populations due to its benefits of ease and speed of implementation; reliable, objective measurement; and repetition of motion. In this study, we introduce a novel outcome measure called the targeted BBT that allows for the study of initiation, grasping, and transport of objects, and also of object release. These modifications to the existing test may increase the ecological validity of the measure while still retaining the previously stated benefits of the standard BBT...
2017: PloS One
https://www.readbyqxmd.com/read/28520864/from-chromatogram-to-analyte-to-metabolite-how-to-pick-horses-for-courses-from-the-massive-web-resources-for-mass-spectral-plant-metabolomics
#20
Leonardo Perez de Souza, Thomas Naake, Takayuki Tohge, Alisdair R Fernie
The grand challenge currently facing metabolomics is the expansion of the coverage of the metabolome from a minor percentage of the metabolic complement of the cell toward the level of coverage afforded by other post-genomic technologies such as transcriptomics and proteomics. In plants, this problem is exacerbated by the sheer diversity of chemicals that constitute the metabolome, with the number of metabolites in the plant kingdom generally considered to be in excess of 200 000. In this review, we focus on web resources that can be exploited in order to improve analyte and ultimately metabolite identification and quantification...
July 1, 2017: GigaScience
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