keyword
https://read.qxmd.com/read/38493489/unpacking-the-perceptions-and-experiences-of-student-facilitators-in-interprofessional-education-a-qualitative-study
#1
JOURNAL ARTICLE
Qing He, Junru Lei, Doris Chong, Pauline Luk, Enoch Chan, Xiaoai Shen, George Lim Tipoe, Linda Chan, Michael M Manio, John Ian Wilzon T Dizon, Fraide A Ganotice
Enhancing health professional students' effective learning and collaborative practice requires a deep understanding of strategies for facilitating interprofessional learning. While faculty members and clinical preceptors are recognized as facilitators in interprofessional education (IPE), there is limited knowledge about the impact of student facilitators' engagement in IPE. Accordingly, this study aims to explore the perceptions and experiences of student facilitators in IPE. Thirteen student facilitators were recruited to lead an interprofessional learning program, and they were subsequently invited to participate in one-on-one interviews...
December 31, 2024: Medical Education Online
https://read.qxmd.com/read/38493447/clinical-practice-guidelines-for-molecular-tumor-marker-2nd-edition-review-part-2
#2
JOURNAL ARTICLE
Yoshinori Kikuchi, Hideaki Shimada, Fumiyuki Yamasaki, Taku Yamashita, Koji Araki, Kohei Horimoto, Satoshi Yajima, Masakazu Yashiro, Keigo Yokoi, Haruhiko Cho, Takuya Ehira, Kazunari Nakahara, Hiroshi Yasuda, Kazutoshi Isobe, Tetsu Hayashida, Shingo Hatakeyama, Koichiro Akakura, Daisuke Aoki, Hiroyuki Nomura, Yuji Tada, Yuki Yoshimatsu, Hayato Miyachi, Chiaki Takebayashi, Ichiro Hanamura, Hiroyuki Takahashi
In recent years, rapid advancement in gene/protein analysis technology has resulted in target molecule identification that may be useful in cancer treatment. Therefore, "Clinical Practice Guidelines for Molecular Tumor Marker, Second Edition" was published in Japan in September 2021. These guidelines were established to align the clinical usefulness of external diagnostic products with the evaluation criteria of the Pharmaceuticals and Medical Devices Agency. The guidelines were scoped for each tumor, and a clinical questionnaire was developed based on a serious clinical problem...
March 17, 2024: International Journal of Clinical Oncology
https://read.qxmd.com/read/38493428/the-estimation-of-acute-oral-toxicity-ld-50-of-g-series-organophosphorus-based-chemical-warfare-agents-using-quantitative-and-qualitative-toxicology-in-silico-methods
#3
JOURNAL ARTICLE
Maciej Noga, Agata Michalska, Kamil Jurowski
The idea of this study was the estimation of the theoretical acute toxicity (t-LD50 , rat, oral dose) of organophosphorus-based chemical warfare agents from the G-series (n = 12) using different in silico methods. Initially identified in Germany, the G-type nerve agents include potent compounds such as tabun, sarin, and soman. Despite their historical significance, there is a noticeable gap in acute toxicity data for these agents. This study employs qualitative (STopTox and AdmetSAR) and quantitative (TEST; CATMoS; ProTox-II and QSAR Toolbox) in silico methods to predict LD50 values, offering an ethical alternative to animal testing...
March 17, 2024: Archives of Toxicology
https://read.qxmd.com/read/38493417/a-reappraisal-of-the-deep-uterine-vein-a-multimodal-exploration-with-implications-for-pelvic-surgery
#4
JOURNAL ARTICLE
Fabien Robin, Léa Roux, Myra A Zaheer, Laurent Sulpice, Ludivine Dion, Vincent Lavoue, Julien Landreau, Xavier Morandi, Krystel Nyangoh Timoh
PURPOSE: Pelvic gynecological surgeries, whether for malignant or benign conditions, frequently result in functional complications due to injuries to the autonomic nervous system. Recognizing the deep uterine vein (DUV) as an essential anatomical reference can aid in preserving these structures. Despite its significance, the DUV is infrequently studied and lacks comprehensive documentation in Terminologia Anatomica. This research endeavors to elucidate a detailed characterization of the DUV...
March 17, 2024: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/38493342/scencore-leveraging-single-cell-epigenetic-data-to-predict-chromatin-conformation-using-graph-embedding
#5
JOURNAL ARTICLE
Ziheng Duan, Siwei Xu, Shushrruth Sai Srinivasan, Ahyeon Hwang, Che Yu Lee, Feng Yue, Mark Gerstein, Yu Luan, Matthew Girgenti, Jing Zhang
Dynamic compartmentalization of eukaryotic DNA into active and repressed states enables diverse transcriptional programs to arise from a single genetic blueprint, whereas its dysregulation can be strongly linked to a broad spectrum of diseases. While single-cell Hi-C experiments allow for chromosome conformation profiling across many cells, they are still expensive and not widely available for most labs. Here, we propose an alternate approach, scENCORE, to computationally reconstruct chromatin compartments from the more affordable and widely accessible single-cell epigenetic data...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38493211/sequence-structure-function-characterization-of-the-emerging-tetracycline-destructase-family-of-antibiotic-resistance-enzymes
#6
JOURNAL ARTICLE
Kevin S Blake, Hirdesh Kumar, Anisha Loganathan, Emily E Williford, Luke Diorio-Toth, Yao-Peng Xue, Wai Kwan Tang, Tayte P Campbell, David D Chong, Steven Angtuaco, Timothy A Wencewicz, Niraj H Tolia, Gautam Dantas
Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance to all generations of tetracycline antibiotics. The recent increase in the number and diversity of reported TDase sequences enables a deep investigation of the TDase sequence-structure-function landscape. Here, we evaluate the sequence determinants of TDase function through two complementary approaches: (1) constructing profile hidden Markov models to predict new TDases, and (2) using multiple sequence alignments to identify conserved positions important to protein function...
March 16, 2024: Communications Biology
https://read.qxmd.com/read/38493202/an-aligned-framework-of-actively-collected-and-passively-monitored-clinical-outcome-assessments-coas-for-measure-selection
#7
JOURNAL ARTICLE
Christine Manta Campbell, Courtney Webster, Megan Parisi, Roya Sherafat-Kazemzadeh, Jessica Braid, Thomas Switzer, Marcelo Alves Fávaro, Caprice Sassano, Andrea Coravos
Regulators increasingly require clinical outcome assessment (COA) data for approval. COAs can be collected via questionnaires or digital health technologies (DHTs), yet no single resource provides a side-by-side comparison of tools that collect complementary or related COA measures. We propose how to align ontologies for actively collected and passively monitored COAs into a single framework to allow for rapid, evidence-based, and fit-for-purpose measure selection.
March 16, 2024: NPJ Digital Medicine
https://read.qxmd.com/read/38493161/poincar%C3%A3-sphere-trajectory-encoding-metasurfaces-based-on-generalized-malus-law
#8
JOURNAL ARTICLE
Zi-Lan Deng, Meng-Xia Hu, Shanfeng Qiu, Xianfeng Wu, Adam Overvig, Xiangping Li, Andrea Alù
As a fundamental property of light, polarization serves as an excellent information encoding carrier, playing significant roles in many optical applications, including liquid crystal displays, polarization imaging, optical computation and encryption. However, conventional polarization information encoding schemes based on Malus' law usually consider 1D polarization projections on a linear basis, implying that their encoding flexibility is largely limited. Here, we propose a Poincaré sphere (PS) trajectory encoding approach with metasurfaces that leverages a generalized form of Malus' law governing universal 2D projections between arbitrary elliptical polarization pairs spanning the entire PS...
March 16, 2024: Nature Communications
https://read.qxmd.com/read/38493130/infrared-a-declarative-tree-decomposition-powered-framework-for-bioinformatics
#9
JOURNAL ARTICLE
Hua-Ting Yao, Bertrand Marchand, Sarah J Berkemer, Yann Ponty, Sebastian Will
MOTIVATION: Many bioinformatics problems can be approached as optimization or controlled sampling tasks, and solved exactly and efficiently using Dynamic Programming (DP). However, such exact methods are typically tailored towards specific settings, complex to develop, and hard to implement and adapt to problem variations. METHODS: We introduce the Infrared framework to overcome such hindrances for a large class of problems. Its underlying paradigm is tailored toward problems that can be declaratively formalized as sparse feature networks, a generalization of constraint networks...
March 16, 2024: Algorithms for Molecular Biology: AMB
https://read.qxmd.com/read/38492946/frailty-and-innovative-participatory-rehabilitation
#10
REVIEW
Martin Skoumal, Martina Honegger, Regina Roller-Wirnsberger
This Mini-Review showcases the latest evidence on rehabilitation opportunities for older people with multimorbidity and frailty. There is growing evidence, that a person-centered and contextualized rehabilitation approach may offer benefits, not only in the context of preserving mobility, but especially targeting social participation. Modern rehabilitation aligns with the bio-psycho-social model of the International Classification of Functioning, Disability and Health (ICF), emphasizing the individual and collaboratively determined definition of personalized rehabilitation goals at the activity and participation level...
March 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38492685/structural-functional-brain-network-coupling-predicts-human-cognitive-ability
#11
JOURNAL ARTICLE
Johanna L Popp, Jonas A Thiele, Joshua Faskowitz, Caio Seguin, Olaf Sporns, Kirsten Hilger
Individual differences in general cognitive ability (GCA) have a biological basis within the structure and function of the human brain. Network neuroscience investigations revealed neural correlates of GCA in structural as well as in functional brain networks. However, whether the relationship between structural and functional networks, the structural-functional brain network coupling (SC-FC coupling), is related to individual differences in GCA remains an open question. We used data from 1030 adults of the Human Connectome Project, derived structural connectivity from diffusion weighted imaging, functional connectivity from resting-state fMRI, and assessed GCA as a latent g-factor from 12 cognitive tasks...
March 14, 2024: NeuroImage
https://read.qxmd.com/read/38492681/efficient-removal-of-ciprofloxacin-and-ofloxacin-from-aqueous-solutions-using-a-novel-nano-scale-adsorbent-modeling-optimization-and-characterization
#12
JOURNAL ARTICLE
Omid Farzinmanesh, Mina Hosseini Sabzevari, Mohammad Reza Asghari
In the fascinating realm of water purification, our study unveils the remarkable potential of a cutting-edge nano-scale adsorbent-combining graphene oxide (GO), chitosan (CS), and polydopamine (PDA)-in efficiently remove ciprofloxacin (CPF) and ofloxacin (OFL) from aqueous solutions. Our exploration delves deep into the adsorbent's character, utilizing a range of analytical techniques including SEM, RAMAN, FTIR, TGA, BET, XRD, and Zeta potential analyses provided insights into the adsorbent's properties. Modeling the adsorption process with Response Surface Methodology (RSM), Artificial Neural Network (ANN) and General Regression Neural Network (GRNN) indicated excellent predictions by GRNN, with RMSE = 0...
March 14, 2024: Chemosphere
https://read.qxmd.com/read/38492568/sound-elicits-stereotyped-facial-movements-that-provide-a-sensitive-index-of-hearing-abilities-in-mice
#13
JOURNAL ARTICLE
Kameron K Clayton, Kamryn S Stecyk, Anna A Guo, Anna R Chambers, Ke Chen, Kenneth E Hancock, Daniel B Polley
Sound elicits rapid movements of muscles in the face, ears, and eyes that protect the body from injury and trigger brain-wide internal state changes. Here, we performed quantitative facial videography from mice resting atop a piezoelectric force plate and observed that broadband sounds elicited rapid and stereotyped facial twitches. Facial motion energy (FME) adjacent to the whisker array was 30 dB more sensitive than the acoustic startle reflex and offered greater inter-trial and inter-animal reliability than sound-evoked pupil dilations or movement of other facial and body regions...
March 6, 2024: Current Biology: CB
https://read.qxmd.com/read/38492563/structural-and-compositional-changes-in-two-marine-shell-traditional-chinese-medicines-a-comparative-analysis-pre-and-post-calcination
#14
JOURNAL ARTICLE
Lizhu Wu, Chenlu Liu, Tao Yao, Yun Shi, Jinyang Shen, Xun Gao, Qin Kunming
BACKGROUND: Arcae concha and Meretricis concha cyclinae concha are two marine shellfish herbs with similar composition and efficacy, which are usually calcined and used clinically. OBJECTIVE: This study investigated variations in the inorganic and organic components of Arcae concha and Meretricis concha cyclinae concha from different production regions, both Arcae concha and Meretricis concha cyclinae concha. The aim was to enhance the understanding of these two types of marine shell traditional Chinese medicine (msTCM) and provide a foundation for their future development and application...
March 16, 2024: Journal of AOAC International
https://read.qxmd.com/read/38492470/feasibility-and-limitations-of-using-commercial-databases-to-evaluate-residential-mobility-in-registry-based-research-on-childhood-cancer
#15
JOURNAL ARTICLE
Lisa M McKenzie, William B Allshouse, Myles Cockburn, Debashis Ghosh
BACKGROUND: Researchers have used commercial databases containing residential addresses to reduce exposure misclassification in case-control studies. Our objective is to evaluate the potential systematic bias regarding case status when reconstructing residential locations from commercial databases. METHODS: Our study population of 3640 Colorado-born children includes 520 children diagnosed with acute lymphocytic leukemia between 2002 and 2019. We aligned addresses and date ranges obtained from LexisNexis with registry dates to determine three dichotomous outcomes: Found in LexisNexis, conception date found in LexisNexis, and reference date/diagnosis date found in LexisNexis...
March 15, 2024: Cancer Epidemiology
https://read.qxmd.com/read/38492409/ophthalmic-care-may-not-align-with-patient-need-an-analysis-on-state-wide-patient-needs-and-provider-density-between-2008-and-2022
#16
JOURNAL ARTICLE
Aidan Gilson, Qingyu Chen, Ron A Adelman
PURPOSE: This study aims to assess the extent to which the demand for ophthalmologic care among patients at the state level is reflected in Google Trends data, serving as an indicator of patient desire in ophthalmology. METHODS: For each state, patient interest in ophthalmologic care was estimated using the Google Trends resource measuring web search and YouTube search rates for multiple ophthalmologic terms. We compared the change in search for ophthalmologic terms over time and used ordinary least squares regression to evaluate whether search interest for ophthalmologic terms was able to predict the rate of practicing ophthalmologists in each state...
March 11, 2024: International Journal of Medical Informatics
https://read.qxmd.com/read/38492252/stadnet-spatial-temporal-attention-guided-dual-path-network-for-cardiac-cine-mri-super-resolution
#17
JOURNAL ARTICLE
Jun Lyu, Shuo Wang, Yapeng Tian, Jing Zou, Shunjie Dong, Chengyan Wang, Angelica I Aviles-Rivero, Jing Qin
Cardiac cine magnetic resonance imaging (MRI) is a commonly used clinical tool for evaluating cardiac function and morphology. However, its diagnostic accuracy may be compromised by the low spatial resolution. Current methods for cine MRI super-resolution reconstruction still have limitations. They typically rely on 3D convolutional neural networks or recurrent neural networks, which may not effectively capture long-range or non-local features due to their limited receptive fields. Optical flow estimators are also commonly used to align neighboring frames, which may cause information loss and inaccurate motion estimation...
March 12, 2024: Medical Image Analysis
https://read.qxmd.com/read/38492188/choice-of-metric-divergence-in-genome-sequence-comparison
#18
JOURNAL ARTICLE
Soumen Ghosh, Jayanta Pal, Bansibadan Maji, Carlo Cattani, Dilip Kumar Bhattacharya
The paper introduces a novel probability descriptor for genome sequence comparison, employing a generalized form of Jensen-Shannon divergence. This divergence metric stems from a one-parameter family, comprising fractions up to a maximum value of half. Utilizing this metric as a distance measure, a distance matrix is computed for the new probability descriptor, shaping Phylogenetic trees via the neighbor-joining method. Initial exploration involves setting the parameter at half for various species. Assessing the impact of parameter variation, trees drawn at different parameter values (half, one-fourth, one-eighth)...
March 16, 2024: Protein Journal
https://read.qxmd.com/read/38492174/eucalyptus-oils-phytochemical-composition-in-correlation-with-their-newly-explored-anti-sars-cov-2-potential-in-vitro-and-in-silico-approaches
#19
JOURNAL ARTICLE
Riham A El-Shiekh, Mona M Okba, Asmaa A Mandour, Omnia Kutkat, Rana Elshimy, Hany A Nagaty, Rehab M Ashour
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest arisen contagious respiratory pathogen related to the global outbreak of atypical pneumonia pandemic (COVID-19). The essential oils (EOs) of Eucalyptus camaldulensis, E. ficifolia F. Muell., E. citriodora Hook, E. globulus Labill, E. sideroxylon Cunn. ex Woolls, and E. torquata Luehm. were investigated for its antiviral activity against SARS-CoV-2. The EOs phytochemical composition was determined using GC/MS analysis. Correlation with the explored antiviral activity was also studied using multi-variate data analysis and Pearson's correlation...
March 16, 2024: Plant Foods for Human Nutrition
https://read.qxmd.com/read/38492170/experiences-participating-in-a-telehealth-exercise-program-among-older-adults-with-cancer-a-qualitative-study
#20
JOURNAL ARTICLE
Emily R Dunston, Alec Malouf, Leslie W Podlog, Maria Newton, Yang Bai, Sonal Oza, Adriana M Coletta
PURPOSE: Telehealth delivery of exercise programs has rapidly increased in recent years; yet, little is known regarding older cancer survivors' (OCS) experiences participating in telehealth exercise. The purpose of this study was to determine OCS barriers and facilitators to participation in telehealth-delivered exercise. METHODS: OCS who participated in a 12-week, one-on-one telehealth exercise program were recruited to participate in one of three focus groups...
March 16, 2024: Journal of Cancer Survivorship: Research and Practice
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