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https://www.readbyqxmd.com/read/29332238/normal-variation-in-sagittal-spinal-alignment-parameters-in-adult-patients-an-eos-study-using-serial-imaging
#1
Hwee Weng Dennis Hey, Kian Loong Melvin Tan, Vikaesh Moorthy, Eugene Tze-Chun Lau, Leok-Lim Lau, Gabriel Liu, Hee-Kit Wong
PURPOSE: To describe normal variations in sagittal spinal radiographic parameters over an interval period and establish physiological norms and guidelines for which these images should be interpreted. METHODS: Data were prospectively collected from a continuous series of adult patients with first-episode mild low back pain presenting to a single institution. The sagittal parameters of two serial radiographic images taken 6-months apart were obtained with the EOS® slot scanner...
January 13, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29332227/accommodative-esotropia-the-state-of-the-art
#2
REVIEW
Andrea Lembo, Massimiliano Serafino, Marika Dello Strologo, Richard A Saunders, Rupal H Trivedi, Edoardo Villani, Paolo Nucci
PURPOSE: To review the state of the art of Accommodative Esotropia (AE) through careful study of what has been reported up to the point in literature. METHODS: A literature search was done on PubMed using key words including "Accommodative esotropia", "Infantile esotropia", "Strabismus" and "Accommodation". We systematically reviewed and critically appraised what has been written about AE and we tried to analyze that according to the current management of AE. RESULTS: Accommodative Esotropia (AE) is a form of strabismus characterized by convergent misalignment of the visual axes that can be associated with hyperopia and abnormal fusional divergence...
January 13, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29332145/the-experiences-and-beliefs-of-older-people-in-scottish-very-sheltered-housing-about-using-multi-compartment-compliance-aids
#3
Derek Stewart, Kathrine Gibson Smith, Joan MacLeod, Alison Strath, Vibhu Paudyal, Katrina Forbes-McKay, Scott Cunningham, Katie MacLure
Background Multi-compartment compliance aids (MCAs) are promoted as a potential solution to medicines non-adherence despite the absence of high quality evidence of effectiveness of MCA use impacting medicines adherence or any clinical outcomes. Furthermore, there is a lack of qualitative research which focuses on the perspectives of older people receiving MCAs. Objectives To describe experiences and beliefs surrounding very sheltered housing (VSH) residents' use of MCAs with emphasis on issues of personalisation, reablement, shared decision-making, independence and support...
January 13, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29331293/toric-lens-implantation-in-cataract-surgery-automated-versus-manual-horizontal-axis-marking-analysis-of-50%C3%A2-cases
#4
M Raucau, H El Chehab, E Agard, C Lagenaite, C Dot
SUBJECT: The main objective of our study was to evaluate the contribution of automated conjunctival registration in the alignment of toric intraocular lenses by comparing automated registration optimized with Callisto® to manual marking of the horizontal axis. MATERIALS AND METHODS: We performed a prospective, descriptive, monocentric study on patients undergoing cataract surgery with a toric intraocular lens (Asphina 709 Zeiss), performed by a surgeon with good experience in toric implants, between September 2016 and March 2017...
January 10, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29331254/technology-alignment-in-the-presence-of-regulatory-changes-the-case-of-meaningful-use-of-information-technology-in-healthcare
#5
Anand Nair, David Dreyfus
OBJECTIVES: Using the context of the healthcare sector, this study examines the impact of regulatory change on technology implementation and use. Hospitals are now federally mandated to showcase meaningful use of information technology (IT). We theorize that IT plan scope structured prior to a regulatory change by means of a long-term planning horizon, top management involvement, and steering committee engagement impacts organizations' ability to fulfill meaningful use requirements three to five years later...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29330855/getting-innovative-therapies-faster-to-patients-at-the-right-dose-impact-of-quantitative-pharmacology-towards-first-registration-and-expanding-therapeutic-use
#6
Satyaprakash Nayak, Oliver Sander, Nidal Al-Huniti, Dinesh de Alwis, Anne Chain, Marylore Chenel, Soujanya Sunkaraneni, Shruti Agrawal, Neeraj Gupta, Sandra A G Visser
Quantitative pharmacology (QP) applications in translational medicine, drug-development, and therapeutic use were crowd-sourced by the ASCPT Impact and Influence initiative. Highlighted QP case studies demonstrated faster access to innovative therapies for patients through 1) rational dose selection for pivotal trials; 2) reduced trial-burden for vulnerable populations; or 3) simplified posology. Critical success factors were proactive stakeholder engagement, alignment on the value of model-informed approaches, and utilizing foundational clinical pharmacology understanding of the therapy...
January 13, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29330745/-treatment-of-rotational-malalignment-of-the-lower-leg
#7
REVIEW
P Keppler
BACKGROUND: Rotational malalignment after intramedullary nailing of tibial shaft fractures is not uncommon. In-toeing and out-toeing conditions in children are often the reason for orthopedic and traumatological medical consultation. OBJECTIVE: Evaluation of diagnostic modalities and therapeutic options for rotational malalignment in relationship to the patient's age. Surgical indications and efficacy of specific surgical techniques. MATERIAL AND METHODS: Systematic literature search in the German Institute for Medical Documentation and Information (DIMDI) and MEDLINE and evaluation of the currently published articles...
January 12, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29330658/patient-specific-model-based-segmentation-of-brain-tumors-in-3d-intraoperative-ultrasound-images
#8
Elisee Ilunga-Mbuyamba, Juan Gabriel Avina-Cervantes, Dirk Lindner, Felix Arlt, Jean Fulbert Ituna-Yudonago, Claire Chalopin
PURPOSE: Intraoperative ultrasound (iUS) imaging is commonly used to support brain tumor operation. The tumor segmentation in the iUS images is a difficult task and still under improvement because of the low signal-to-noise ratio. The success of automatic methods is also limited due to the high noise sensibility. Therefore, an alternative brain tumor segmentation method in 3D-iUS data using a tumor model obtained from magnetic resonance (MR) data for local MR-iUS registration is presented in this paper...
January 12, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29330648/cloning-expression-and-characterization-of-the-esterase-estut1-from-ureibacillus-thermosphaericus-which-belongs-to-a-new-lipase-family-xviii
#9
Yuliya V Samoylova, Ksenia N Sorokina, Margarita V Romanenko, Valentin N Parmon
A new esterase gene from thermophilic bacteria Ureibacillus thermosphaericus was cloned into the pET32b vector and expressed in Escherichia coli BL21(DE3). Alignment of the estUT1 amino acid sequence revealed the presence of a novel canonical pentapeptide (GVSLG) and 41-47% identity to the closest family of the bacterial lipases XIII. Thus the esterase estUT1 from U. thermosphaericus was assigned as a member of the novel family XVIII. It also showed a strong activity toward short-chain esters (C2-C8), with the highest activity for C2...
January 12, 2018: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29330588/whole-body-3d-kinematics-of-bird-take-off-key-role-of-the-legs-to-propel-the-trunk
#10
Pauline Provini, Anick Abourachid
Previous studies showed that birds primarily use their hindlimbs to propel themselves into the air in order to take-off. Yet, it remains unclear how the different parts of their musculoskeletal system move to produce the necessary acceleration. To quantify the relative motions of the bones during the terrestrial phase of take-off, we used biplanar fluoroscopy in two species of birds, diamond dove (Geopelia cuneata) and zebra finch (Taeniopygia guttata). We obtained a detailed 3D kinematics analysis of the head, the trunk and the three long bones of the left leg...
January 6, 2018: Die Naturwissenschaften
https://www.readbyqxmd.com/read/29330498/replication-of-biocompatible-nanotopographic-surfaces
#11
Xiaoyu Sun, Matt J Hourwitz, Eleni M Baker, B U Sebastian Schmidt, Wolfgang Losert, John T Fourkas
The ability of cells to sense and respond to nanotopography is being implicated as a key element in many physiological processes such as cell differentiation, immune response, and wound healing, as well as in pathologies such as cancer metastasis. To understand how nanotopography affects cellular behaviors, new techniques are required for the mass production of biocompatible, rigid nanotopographic surfaces. Here we introduce a method for the rapid and reproducible production of biocompatible, rigid, acrylic nanotopographic surfaces, and for the functionalization of the surfaces with adhesion-promoting molecules for cell experiments...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330318/shifting-meiotic-to-mitotic-spindle-assembly-in-oocytes-disrupts-chromosome-alignment
#12
Isma Bennabi, Isabelle Quéguiner, Agnieszka Kolano, Thomas Boudier, Philippe Mailly, Marie-Hélène Verlhac, Marie-Emilie Terret
Mitotic spindles assemble from two centrosomes, which are major microtubule-organizing centers (MTOCs) that contain centrioles. Meiotic spindles in oocytes, however, lack centrioles. In mouse oocytes, spindle microtubules are nucleated from multiple acentriolar MTOCs that are sorted and clustered prior to completion of spindle assembly in an "inside-out" mechanism, ending with establishment of the poles. We used HSET (kinesin-14) as a tool to shift meiotic spindle assembly toward a mitotic "outside-in" mode and analyzed the consequences on the fidelity of the division...
January 12, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29330243/task-delegation-and-burnout-trade-offs-among-primary-care-providers-and-nurses-in-veterans-affairs-patient-aligned-care-teams-va-pacts
#13
Samuel T Edwards, Christian D Helfrich, David Grembowski, Elizabeth Hulen, Walter L Clinton, Gordon B Wood, Linda Kim, Danielle E Rose, Greg Stewart
PURPOSE: Appropriate delegation of clinical tasks from primary care providers (PCPs) to other team members may reduce employee burnout in primary care. However, (1) the extent to which delegation occurs within multidisciplinary teams, (2) factors associated with greater delegation, and (3) whether delegation is associated with burnout are all unknown. METHODS: We performed a national cross-sectional survey of Veterans Affairs (VA) PCP-nurse dyads in Department of VA primary care clinics, 4 years into the VA's patient-centered medical home initiative...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330237/-the-hand-on-the-doorknob-visit-agenda-setting-by-complex-patients-and-their-primary-care-physicians
#14
Christine P Kowalski, Deanna B McQuillan, Neetu Chawla, Courtney Lyles, Andrea Altschuler, Connie S Uratsu, Elizabeth A Bayliss, Michele Heisler, Richard W Grant
BACKGROUND: Choosing which issues to discuss in the limited time available during primary care visits is an important task for complex patients with chronic conditions. DESIGN, SETTING, AND PARTICIPANTS: We conducted sequential interviews with complex patients (n = 40) and their primary care physicians (n = 17) from 3 different health systems to investigate how patients and physicians prepare for visits, how visit agendas are determined, and how discussion priorities are established during time-limited visits...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330131/response-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-to-several-pharmacological-agents-when-intrinsic-syncytial-pacing-is-overcome-by-acute-external-stimulation
#15
Haoyu Zeng, Bharathi Balasubramanian, Armando Lagrutta, Frederick Sannajust
We challenged human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) syncytia, mainly, CDI iCells with several classes of well-characterized pharmacological agents (including hERG blocker, Nav1.5 blocker, Cav1.2 blocker and opener, β-adrenergic agonist, and If blocker) under pacing conditions, utilizing the Cardio-ECR instrument, a non-invasive platform featuring simultaneous and continuous measurement of synchronized beating rate and contractility (both signals were acquired simultaneously and well aligned) ...
January 9, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29330032/a-free-sugars-daily-value-dv-identifies-more-less-healthy-prepackaged-foods-and-beverages-than-a-total-sugars-dv
#16
Jodi T Bernstein, Marie-Ève Labonté, Beatriz Franco-Arellano, Alyssa Schermel, Mary R L'Abbé
Regulatory changes in Canada will require food labels to have a benchmark [% Daily Value, %DV] for total sugars, based on 100 g/day, while US labels will require a %DV for added sugars, based on 50 g/day. The objective of this study was to compare two labelling policies, a total sugars DV (100 g/day) and a free sugars DV (50 g/day) on food labels. This cross-sectional analysis of the Food Label Information Program database focussed on top sources of total sugars intake in Canada (n = 6924 foods)...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29329952/molecular-characterization-and-expression-of-complement-factor-i-in-pelteobagrus-vachellii-during-aeromonas-hydrophila-infection
#17
Chuanjie Qin, Quan Gong, Zhengyong Wen, Dengyue Yuan
Complement factor I (CFI) is a novel regulatory serine protease that plays an important role in resistance to pathogen infection. In this study, the CFI gene of Pelteobagrus vachellii (Pv-CFI) was sequenced and characterized. The full-length cDNA of 2320 bp includes a 155 bp 5'-untranslated region (UTR), a 164 bp 3'-UTR, and a 2001 bp open reading frame (ORF) encoding a 667 amino acids. Multiple sequence alignment revealed five highly conserved domains with a typical modular architecture and identical active sites in vertebrates, indicating a conserved function...
January 9, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29329788/effect-of-individualized-distal-femoral-valgus-resection-angle-in-primary-total-knee-arthroplasty-a-systematic-review-and-meta-analysis-involving-1300-subjects
#18
REVIEW
Kai Zhou, Tingxian Ling, Yuan Xu, Jinglong Li, Haoda Yu, Haoyang Wang, Zongke Zhou, Fuxing Pei
BACKGROUND: Proper limb alignment and implant positioning are important for successful total knee arthroplasty (TKA). Whether any differences exist in restoration of limb alignment for valgus knees between fixed and individual femoral valgus correction angle (VCA) for distal femoral resection remains unknown. METHODS: The PubMed, Medline, Embase, and Wangfang databases were searched to identify studies comparing individualized VCA and fixed VCA in the distal femoral valgus resection...
January 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29329669/prevalence-and-predictors-of-symptom-resolution-and-functional-restoration-in-the-index-knee-following-knee-arthroplasty-a-longitudinal-study
#19
Daniel L Riddle
OBJECTIVES: To determine the prevalence of a one- to two-year postsurgical pain-free state and pain plus symptom-free state as well as function restoration following knee arthroplasty (KA). A second purpose was to identify predictors of these outcomes. DESIGN: An inception cohort from the Osteoarthritis Initiative (OAI) dataset, a nine-year NIH funded cohort study of persons with or at high risk for knee osteoarthritis was studied. SETTING: Subjects were recruited from the communities of four sites in the Midwest, Eastern and Southeastern United States...
January 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29329459/using-pool-seq-to-search-for-genomic-regions-affected-by-hybrid-inviability-in-the-copepod-t-californicus
#20
Thiago G Lima, Christopher S Willett
The formation of reproductive barriers between allopatric populations involves the accumulation of incompatibilities that lead to intrinsic postzygotic isolation. The evolution of these incompatibilities is usually explained by the Dobzhansky-Muller model, where epistatic interactions that arise within the diverging populations, lead to deleterious interactions when they come together in a hybrid genome. These incompatibilities can lead to hybrid inviability, killing individuals with certain genotypic combinations, and causing the population's allele frequency to deviate from Mendelian expectations...
January 10, 2018: Journal of Heredity
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