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Anabolics in medicine

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https://www.readbyqxmd.com/read/27852127/artemisia-capillaris-alleviates-bone-loss-by-stimulating-osteoblast-mineralization-and-suppressing-osteoclast-differentiation-and-bone-resorption
#1
Chung-Jo Lee, Ki-Shuk Shim, Jin Yeul Ma
Artemisia capillaris has been used to treat jaundice and relieve high liver-heat in traditional medicine. In this study, we found that the administration of a water extract from A. capillaris (WEAC) to the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced bone loss model significantly prevents osteoporotic bone loss, increasing bone volume/trabecular volume by 22% and trabecular number by 24%, and decreasing trabecular separation by 29%. WEAC stimulated in vitro osteoblast mineralization from primary osteoblasts in association with increasing expression of osterix, nuclear factor of activated T cells cytoplasmic 1, and activator protein-1, as well as phosphorylation of extracellular signal-regulated kinase...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27758689/mechanisms-of-anorexia-cancer-cachexia-syndrome-and-potential-benefits-of-traditional-medicine-and-natural-herbs
#2
Cong Ming-Hua, Zou Bao-Hua, Yu Lei
Anorexia cancer cachexia syndrome is prevalent in advanced cancer patients, which is featured by anorexia, decreased dietary intake, body weight loss (skeletal muscle mass loss), and unable to be reversed by routine nutritional support therapy. Up to now, the main mechanisms involved in cancer cachexia include excessive systemic inflammation, which is represented by increased plasma levels of IL-1, IL-6, TNF-alpha, tumor-induced factors, such as PIF and LMF. These factors eventually act on orexigenic and anorexigenic neurons located in hypothalamus or protein and lipid metabolism of peripheral tissues, which lead to anorexia, decreased dietary intake, enhanced basic metabolism rate and hyper catabolism...
October 18, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27610386/prp-treatment-efficacy-for-tendinopathy-a-review-of-basic-science-studies
#3
REVIEW
Yiqin Zhou, James H-C Wang
Platelet-Rich Plasma (PRP) has been widely used in orthopaedic surgery and sport medicine to treat tendon injuries. However, the efficacy of PRP treatment for tendinopathy is controversial. This paper focuses on reviewing the basic science studies on PRP performed under well-controlled conditions. Both in vitro and in vivo studies describe PRP's anabolic and anti-inflammatory effects on tendons. While some clinical trials support these findings, others refute them. In this review, we discuss the effectiveness of PRP to treat tendon injuries with evidence presented in basic science studies and the potential reasons for the controversial results in clinical trials...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27552474/potential-harmful-effects-of-dietary-supplements-in-sports-medicine
#4
Louise Deldicque, Marc Francaux
PURPOSE OF REVIEW: The purpose of this article is to collect the most recent data regarding the safety of well-known or emerging dietary supplements used by athletes. RECENT FINDINGS: From January 2014 to April 2016, about 30 articles have been published in the field. New data show that 90% of sports supplements contain trace of estrogenic endocrine disruptors, with 25% of them having a higher estrogenic activity than acceptable. About 50% of the supplements are contaminated by melamine, a source of nonprotein nitrogen...
November 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27516660/complementary-and-alternative-medicine-for-osteoporosis
#5
Zahra Alsadat Hejazi, Forough Namjooyan, Marjan Khanifar
BACKGROUND: A systemic skeletal disease is characterized by low bone mass and micro-architectural deterioration with a consequent increase in bone fragility and susceptibility to fracture. Asia has the highest increment in the elderly population; therefore, osteoporotic fracture should be a noticeable health issue. The incidence rate of hip fractures in Asia could rise to 45% by the year 2050. Complementary and alternative medicine (CAM) is a group of various medical and health care systems, practices, and products that are not presently considered as part of formal medicine...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27411303/stem-cell-procedures-in-arthroscopic-surgery
#6
REVIEW
Felix Dyrna, Elmar Herbst, Alexander Hoberman, Andreas B Imhoff, Andreas Schmitt
The stem cell as the building block necessary for tissue reparation and homeostasis plays a major role in regenerative medicine. Their unique property of being pluripotent, able to control immune process and even secrete a whole army of anabolic mediators, draws interest. While new arthroscopic procedures and techniques involving stem cells have been established over the last decade with improved outcomes, failures and dissatisfaction still occur. Therefore, there is increasing interest in ways to improve the healing response...
2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/27392567/mechanical-and-vascular-cues-synergistically-enhance-osteogenesis-in-human-mesenchymal-stem-cells
#7
Andrew J Steward, Jacqueline H Cole, Frances S Ligler, Elizabeth G Loboa
Development and maintenance of a vascular network are critical for bone growth and homeostasis; strategies that promote vascular function are critical for clinical success of tissue-engineered bone constructs. Co-culture of endothelial cells (ECs) with mesenchymal stem cells (MSCs) and exposure to 10% cyclic tensile strain have both been shown to regulate osteogenesis in isolation, but potential synergistic effects have yet to be explored. The objective of this study was to expose an MSC-EC co-culture to 10% cyclic tensile strain to examine the role of this mechanical stimulus on MSC-EC behavior...
August 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27391622/champ-symposium-on-androgens-anabolic-steroids-and-related-substances-what-we-know-and-what-we-need-to-know
#8
Melissa L Givens, Patricia A Deuster, Brian R Kupchak
The Consortium of Health and Military Performance hosted a symposium in April 2015 entitled "Androgens, Anabolic Steroids, and Related Substances: What We Know and What We Need to Know" in response to concerns from the field regarding Anabolic Androgenic Steroids use by U.S. service members. The symposium was attended by military and civilian subject-matter experts in sports medicine and anabolic steroids and was held at the United Service Organizations (Naval Support Activity Bethesda) in Bethesda, Maryland...
July 2016: Military Medicine
https://www.readbyqxmd.com/read/27354458/use-of-performance-enhancing-substances
#9
Michele LaBotz, Bernard A Griesemer
Performance-enhancing substances (PESs) are used commonly by children and adolescents in attempts to improve athletic performance. More recent data reveal that these same substances often are used for appearance-related reasons as well. PESs include both legal over-the-counter dietary supplements and illicit pharmacologic agents. This report reviews the current epidemiology of PES use in the pediatric population, as well as information on those PESs in most common use. Concerns regarding use of legal PESs include high rates of product contamination, correlation with future use of anabolic androgenic steroids, and adverse effects on the focus and experience of youth sports participation...
July 2016: Pediatrics
https://www.readbyqxmd.com/read/27339274/plant-ecdysteroids-plant-sterols-with-intriguing-distributions-biological-effects-and-relations-to-plant-hormones
#10
REVIEW
Danuše Tarkowská, Miroslav Strnad
The present review summarises current knowledge of phytoecdysteroids' biosynthesis, distribution within plants, biological importance and relations to plant hormones. Plant ecdysteroids (phytoecdysteroids) are natural polyhydroxylated compounds that have a four-ringed skeleton, usually composed of either 27 carbon atoms or 28-29 carbon atoms (biosynthetically derived from cholesterol or other plant sterols, respectively). Their physiological roles in plants have not yet been confirmed and their occurrence is not universal...
September 2016: Planta
https://www.readbyqxmd.com/read/27316792/a-neoflavonoid-dalsissooal-isolated-from-heartwood-of-dalbergia-sissoo-roxb-has-bone-forming-effects-in-mice-model-for-osteoporosis
#11
Priyanka Kushwaha, Vikram Khedgikar, Naseer Ahmad, Anirudha Karvande, Jyoti Gautam, Padam Kumar, Rakesh Maurya, Ritu Trivedi
Dalbergia sissoo Roxb. is a well known medicinal plant of India, enriched with various flavonoids used for treating multiple diseases. Earlier, we have shown that extract of Dalbergia sissoo Roxb. leaves mitigate ovariectomy induced bone loss and pure compounds (neoflavonoids) isolated from it, promote osteoblastogenesis in primary calvarial osteoblasts cells in vitro. Here, we hypothesize that dalsissooal (DSL), a novel neoflavonoid isolated from the heartwood of Dalbergia sissoo Roxb. is an important constituent of the extract that imparts bone forming effects...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27280935/effects-of-a-hot-water-extract-of-allium-hookeri-roots-on-bone-formation-in-human-osteoblast-like-mg-63-cells-in-vitro-and-in-rats-in-vivo
#12
Heajin Park, Jaehoon Jeong, Hanbit Hyun, Jihye Kim, Haesung Kim, Hyun Il Oh, Jai Yeon Choi, Hye Seong Hwang, Doo Byung Oh, Jae Il Kim, Ha Hyung Kim
Allium hookeri is a wild herb found mainly in the Himalayas, growing at altitudes of 1400-4200 m. A. hookeri is widely consumed as a vegetable and herbal medicine in Asia, but its effects on bone health have not been reported previously. This study investigated the effects of a hot-water extract of A. hookeri roots on bone formation. The hot-water extract significantly increased the proliferation of in vitro human osteoblast-like MG-63 cells and the stimulatory effects on osteoblast differentiation were noticeably greater for the hot-water extract than for daidzein (a positive control), as reflected by alkaline phosphatase activity, collagen content, and mineral deposition...
June 9, 2016: Planta Medica
https://www.readbyqxmd.com/read/27264191/ethanol-extract-of-cissus-quadrangularis-enhances-osteoblast-differentiation-and-mineralization-of-murine-pre-osteoblastic-mc3t3-e1-cells
#13
Raazia Tasadduq, Jonathan Gordon, Khalid A Al-Ghanim, Jane B Lian, Andre J Van Wijnen, Janet L Stein, Gary S Stein, Abdul Rauf Shakoori
Traditional medicinal literature and previous studies have reported the possible role of Cissus quadrangularis (CQ) as an anti-osteoporotic agent. This study examines the effectiveness of CQ in promoting osteoblast differentiation of the murine pre-osteoblast cell line, MC3T3-E1. Ethanolic extract of CQ (CQ-E) was found to affect growth kinetics of MC3T3-E1 cells in a dosage-dependent manner. High concentrations of CQ-E (more than 10 μg/ml) have particularly adverse effects, while lower concentrations of 0...
March 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27160996/characteristics-and-health-benefits-of-phytochemicals
#14
Claus Leitzmann
In food science the term 'phytochemicals' includes a variety of plant ingredients with different structures that are capable of health-promoting effects. Phytonutrients are natural substances but are not called nutrients in the traditional sense, since they are synthesized by plants neither in energy metabolism nor in anabolic or catabolic metabolism, but only in specific cell types. They differ from primary plant compounds in that they are not essential to the plant. Phytonutrients perform important tasks in the secondary metabolism of plants as repellents to pests and sunlight as well as growth regulators...
2016: Forschende Komplementärmedizin, Research in Complementary Medicine
https://www.readbyqxmd.com/read/26990774/specific-characterization-of-non-steroidal-selective-androgen-peceptor-modulators-using-supercritical-fluid-chromatography-coupled-to-ion-mobility-mass-spectrometry-application-to-the-detection-of-enobosarm-in-bovine-urine
#15
Laure Beucher, Gaud Dervilly-Pinel, Nora Cesbron, Mylène Penot, Audrey Gicquiau, Fabrice Monteau, Bruno Le Bizec
Currently under development for therapeutic purposes in human medicine, non-steroidal selective androgen receptor modulators (non-steroidal SARMs) are also known to impact growth associated pathways. As such, they present a potential for abuse in sports and food-producing animals as interesting alternative anabolic substances. Forbidden since 2008 by the World Anti-Doping Agency (WADA) these compounds are however easily available and could be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies have to be developed for specific and sensitive detection of these compounds in biological matrices...
March 16, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/26983755/coordinate-regulatory-osteogenesis-effects-of-icariin-timosaponin-b-ii-and-ferulic-acid-from-traditional-chinese-medicine-formulas-on-umr-106-osteoblastic-cells-and-osteoblasts-in-neonatal-rat-calvaria-cultures
#16
Mei Li, Nai-Dan Zhang, Yin Wang, Ting Han, Yi-Ping Jiang, Khalid Rahman, Lu-Ping Qin, Hai-Liang Xin, Qiao-Yan Zhang
ETHNOPHARMACOLOGICAL SIGNIFICANCE: Icariin (I), ferulic acid (F) and timosaponin B II (T) derived respectively from the leaf of Epimedium brevicornu Maxim (EBM, Berberidaceae), rhizome of Anemarrhena asphodeloides Bunge (AAB, Liliaceae) and root of Angelica sinensis (Oliv.) Diels (ASD, Umbelliferae) are included in several traditional Chinese medicine (TCM) formulas for the treatment of osteoporosis. In addition, the medicinal materials and chemical constituents in many traditional Chinese formulas have been shown to have potential synergistic, additive and antagonistic effects...
June 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26927096/de-novo-transcriptome-assembly-in-shiraia-bambusicola-to-investigate-putative-genes-involved-in-the-biosynthesis-of-hypocrellin-a
#17
Ning Zhao, Xi Lin, Shan-Shan Qi, Zhi-Mei Luo, Shuang-Lin Chen, Shu-Zhen Yan
Shiraia bambusicola is a species of the monotypic genus Shiraia in the phylum Ascomycota. In China, it is known for its pharmacological properties that are used to treat rheumatic arthritis, sciatica, pertussis, tracheitis and so forth. Its major medicinal active metabolite is hypocrellin A, which exhibits excellent antiviral and antitumor properties. However, the genes involved in the hypocrellin A anabolic pathways were still unknown due to the lack of genomic information for this species. To investigate putative genes that are involved in the biosynthesis of hypocrellin A and determine the pathway, we performed transcriptome sequencing for Shiraia bambusicola S4201-W and the mutant S4201-D1 for the first time...
February 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26849131/diacerein-benefits-risks-and-place-in-the-management-of-osteoarthritis-an-opinion-based-report-from-the-esceo
#18
REVIEW
Karel Pavelka, Olivier Bruyère, Cyrus Cooper, John A Kanis, Burkhard F Leeb, Emmanuel Maheu, Johanne Martel-Pelletier, Jordi Monfort, Jean-Pierre Pelletier, René Rizzoli, Jean-Yves Reginster
Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA...
February 2016: Drugs & Aging
https://www.readbyqxmd.com/read/26799635/bioenergetic-reprogramming-of-articular-chondrocytes-by-exposure-to-exogenous-and-endogenous-reactive-oxygen-species-and-its-role-in-the-anabolic-response-to-low-oxygen
#19
H K Heywood, D A Lee
Monolayer culture is integral to many cell-based cartilage repair strategies, but chondrocytes lose regenerative potential with increasing duration in vitro. This coincides with elevated reactive oxygen species (ROS) levels and a bioenergetic transformation characterized by increasing mitochondrial function. This study investigates ROS as stimuli for bioenergetic reprogramming and the effect of antioxidants on the propensity of chondrocytes to regenerate a cartilaginous matrix. Articular chondrocytes were cultured in monolayer under a 2% O2 atmosphere...
January 22, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/26793854/peculiarities-of-pharmacotherapy-in-arterial-hypertension-and-comorbid-pathology
#20
Nataliia Tofan, Muza Marish, V Shtanko
UNLABELLED: In patients with arterial hypertension (AH) pharmacotherapy often remains ineffective because of comorbid pathology. Research of haemodynamic and metabolic processes in such patients allows prescribe effective antihypertensive medicines, improve life quality and prognosis. MATERIAL AND METHODS: 60 patients with AH, coronary artery disease and obesity were divided into three groups: 1st group was treated with lisinopril + atorvastatin + aspirin (regimen I); 2nd group was treated with lisinopril + atorvastatin + bisoprolol + aspirin (regimen II); 3rd group was treated with lisinopril + bisoprolol + indapamide + atorvastatin + aspirin (regimen III)...
October 2015: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
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