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https://www.readbyqxmd.com/read/28158982/study-protocol-thyroid-hormone-replacement-for-untreated-older-adults-with-subclinical-hypothyroidism-a-randomised-placebo-controlled-trial-trust
#1
David J Stott, Jacobijn Gussekloo, Patricia M Kearney, Nicolas Rodondi, Rudi G J Westendorp, Simon Mooijaart, Sharon Kean, Terence J Quinn, Naveed Sattar, Kirsty Hendry, Robert Du Puy, Wendy P J Den Elzen, Rosalinde K E Poortvliet, Jan W A Smit, J Wouter Jukema, Olaf M Dekkers, Manuel Blum, Tinh-Hai Collet, Vera McCarthy, Caroline Hurley, Stephen Byrne, John Browne, Torquil Watt, Douglas Bauer, Ian Ford
BACKGROUND: Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the effect of thyroid hormone treatment. We describe the protocol of a large randomised controlled trial (RCT) of Levothyroxine treatment for SCH. METHODS: Participants are community-dwelling subjects aged ≥65 years with SCH, diagnosed by elevated TSH levels (≥4...
February 3, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28143953/hemolytic-anemia-repressed-hepcidin-level-without-hepatocyte-iron-overload-lesson-from-g%C3%A3-nther-disease-model
#2
Sarah Millot, Constance Delaby, Boualem Moulouel, Thibaud Lefebvre, Nathalie Pilard, Nicolas Ducrot, Cécile Ged, Philippe Lettéron, Lucia de Franceschi, Jean Charles Deybach, Carole Beaumont, Laurent Gouya, Hubert De Verneuil, Saïd Lyoumi, Hervé Puy, Zoubida Karim
Hemolysis occurring in hematologic diseases is often associated with an iron loading anemia. This iron overload is the result of a massive outflow of hemoglobin into the bloodstream, but the mechanism of hemoglobin handling has not been fully elucidated. Here, in a congenital erythropoietic porphyria mouse model, we evaluate the impact of hemolysis and regenerative anemia on hepcidin synthesis and iron metabolism. Hemolysis was confirmed by a complete drop in haptoglobin, hemopexin and increased plasma lactate dehydrogenase, an increased red blood cell distribution width and osmotic fragility, a reduced half-life of red blood cells, and increased expression of heme oxygenase 1...
February 2017: Haematologica
https://www.readbyqxmd.com/read/28124063/nucleic-acids-as-cofactors-for-factor-xi-and-prekallikrein-activation-different-roles-for-high-molecular-weight-kininogen
#3
Ivan Ivanov, Mao-Fu Sun, S Kent Dickeson, Cristina Puy, Owen J T McCarty, Andras Gruber, Anton Matafonov, David Gailani
The plasma zymogens factor XI (fXI) and prekallikrein (PK) are activated by factor XIIa (fXIIa) during contact activation. Polyanions such as DNA and RNA may contribute to thrombosis and inflammation partly by enhancing PK and fXI activation. We examined PK and fXI activation in the presence of nucleic acids, and determine the effects of the cofactor high molecular weight kininogen (HK) on the reactions. In the absence of HK, DNA and RNA induced of fXI autoactivation. Proteases known to activate fXI (fXIIa and thrombin) did not enhance this process appreciably...
January 26, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28118224/acute-hepatic-and-erythropoietic-porphyrias-from-ala-synthases-1-and-2-to-new-molecular-bases-and-treatments
#4
Hana Manceau, Laurent Gouya, Hervé Puy
PURPOSE OF REVIEW: Many studies over the past decade have together identified new genes including modifier genes and new regulation and pathophysiological mechanisms in inherited inborn diseases of the heme biosynthetic pathway. A new porphyria has been characterized: X-linked protoporphyria and the perspective to have innovative treatment at very short-term became a reality. We will summarize how recent data on both ALAS1 and ALAS2 have informed our understanding of disease pathogenesis with an emphasis on how this information may contribute to new therapeutic strategies...
January 21, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28096032/creation-of-an-intensive-care-unit-and-organizational-changes-in-an-adult-emergency-department-impact-on-acute-stroke-management
#5
Laurent Puy, Chantal Lamy, Sandrine Canaple, Audrey Arnoux, Nicolas Laine, Ella Iacob, Jean-Marc Constans, Olivier Godefroy
BACKGROUND AND PURPOSE: Following the reorganization of a University Medical Center onto a single campus, an Intensive Care Unit was created within the adult Emergency Department (ED ICU). We assessed the effects of these organizational changes on acute stroke management and the intravenous administration of recombinant tissue plasminogen activator (IV rtPA), as characterized by the thrombolysis rate, door-to-needle time (DNT) and outcome at 3months. METHODS: Between October 2013 and September 2015, we performed a retrospective, observational, single-center, comparative study of patients admitted for ischemic stroke and treated with IV rtPA during two 321-day periods (before and after the creation of the ED ICU)...
January 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28042864/synthesis-and-antibacterial-evaluation-of-new-sulfone-derivatives-containing-2-aroxymethyl-1-3-4-oxadiazole-thiadiazole-moiety
#6
Shihu Su, Xia Zhou, Guoping Liao, Puying Qi, Linhong Jin
Sulfones are one of the most important classes of agricultural fungicides. To discover new lead compounds with high antibacterial activity, a series of new sulfone derivatives were designed and synthesized by introducing the aroxymethyl moiety into the scaffold of 1,3,4-oxadiazole/thiadiazole sulfones. Antibacterial activities against three phytopathogens (Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, Xanthomonas axonopodis pv. citri.) were assayed in vitro. As compared to the control of commercial fungicides and some reported sulfone fungicides, seven compounds 5I-1-5I-7 exerted remarkably higher activities with EC50 values ranging from 0...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28031405/a-variant-of-peptide-transporter-2-predicts-the-severity-of-porphyria-associated-kidney-disease
#7
Dimitri Tchernitchko, Quentin Tavernier, Jérôme Lamoril, Caroline Schmitt, Neila Talbi, Said Lyoumi, Anne-Marie Robreau, Zoubida Karim, Laurent Gouya, Eric Thervet, Alexandre Karras, Hervé Puy, Nicolas Pallet
CKD occurs in most patients with acute intermittent porphyria (AIP). During AIP, δ-aminolevulinic acid (ALA) accumulates and promotes tubular cell death and tubulointerstitial damage. The human peptide transporter 2 (PEPT2) expressed by proximal tubular cells mediates the reabsorption of ALA, and variants of PEPT2 have different affinities for ALA. We tested the hypothesis that PEPT2 genotypes affect the severity and prognosis of porphyria-associated kidney disease. We analyzed data from 122 individuals with AIP who were followed from 2003 to 2013 and genotyped for PEPT2 At last follow-up, carriers of the PEPT2*1*1 genotype (higher affinity variant) exhibited worse renal function than carriers of the lower affinity variants PEPT2*1/*2 and PEPT2*2/*2 (mean±SD eGFR: 54...
December 28, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27979315/quality-criteria-in-bariatric-surgery-consensus-review-and-recommendations-of-the-spanish-association-of-surgeons-and-the-spanish-society-of-bariatric-surgery
#8
Fátima Sabench Pereferrer, Eduardo Domínguez-Adame Lanuza, Ainitze Ibarzabal, María Socas Macias, Víctor Valentí Azcárate, Amador García Ruiz de Gordejuela, Francisca García-Moreno Nisa, Jesús González Fernández, Ramón Vilallonga Puy, Nuria Vilarrasa García, Raquel Sánchez Santos
Bariatric surgery has proven to be highly effective in controlling obesity and metabolic syndrome; the results of this surgery are not only expressed in terms of weight loss, but also in terms of resolution of comorbidities, improved quality of life and complications. The different parameters used to measure these outcomes require uniformity and reference patterns. Therefore, it is essential to identify those indicators and quality criteria that are helpful in defining the «best practice» principles in bariatric surgery...
December 12, 2016: Cirugía Española
https://www.readbyqxmd.com/read/27976148/innovative-bioguided-fractionation-of-cranberry-juice-for-candida-biofilm-treatment-and-infected-wound-healing
#9
L Boudesocque-Delaye, T Puy, M Girardot, A Lanoue, L Bazinet, C Bodet, C Imbert, C Enguehard-Gueiffier
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27933406/differential-roles-for-the-coagulation-factors-xi-and-xii-in-regulating-the-physical-biology-of-fibrin
#10
Joanna L Sylman, Uranbileg Daalkhaijav, Ying Zhang, Elliot M Gray, Parsa A Farhang, Tiffany T Chu, Jevgenia Zilberman-Rudenko, Cristina Puy, Erik I Tucker, Stephanie A Smith, James H Morrissey, Travis W Walker, Xiaolin L Nan, András Gruber, Owen J T McCarty
In the contact activation pathway of the coagulation, zymogen factor XII (FXII) is converted to FXIIa, which triggers activation of FXI leading to the activation of FIX and subsequent thrombin generation and fibrin formation. Feedback activation of FXI by thrombin has been shown to promote thrombin generation in a FXII-independent manner and FXIIa can bypass FXI to directly activate FX and prothrombin in the presence of highly negatively charged molecules, such as long-chain polyphosphates (LC polyP). We sought to determine whether activation of FXII or FXI differentially regulate the physical biology of fibrin formation...
December 8, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27769258/reasons-for-transferral-to-emergency-departments-of-terminally-ill-patients-a-french-descriptive-and-retrospective-study
#11
Pierre Cornillon, Sébastien Loiseau, Bruno Aublet-Cuvelier, Virginie Guastella
BACKGROUND: Patients under palliative care and in hospital-at-home services are frequently transferred to emergency departments. We set out to identify the reasons for these presentations to determine the proportion that might be avoidable. METHODS: We conducted a retrospective study by assessment of patient files. We studied admissions to four emergency departments in an area of France (Puy-de-Dôme) between September 2011 and August 2013. Reasons for transfer and diagnostic conclusion by emergency doctors were noted...
October 21, 2016: BMC Palliative Care
https://www.readbyqxmd.com/read/27764259/platelet-derived-short-chain-polyphosphates-enhance-the-inactivation-of-tissue-factor-pathway-inhibitor-by-activated-coagulation-factor-xi
#12
Cristina Puy, Erik I Tucker, Ivan S Ivanov, David Gailani, Stephanie A Smith, James H Morrissey, András Gruber, Owen J T McCarty
INTRODUCTION: Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in vitro. Some of these reactions are now known to be enhanced by short-chain polyphosphates (SCP) derived from activated platelets. These SCPs act as a cofactor for the activation of FXI and FV by thrombin and FXIa, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27660851/accumulation-of-mg-to-diffusive-gradients-in-thin-films-dgt-devices-kinetic-and-thermodynamic-effects-of-the-ionic-strength
#13
Alexandra Altier, Martín Jiménez-Piedrahita, Carlos Rey-Castro, Joan Cecilia, Josep Galceran, Jaume Puy
Availability of magnesium is a matter of concern due to its role in many environmental and biological processes. Diffusive Gradients in Thin Films (DGT) devices can measure Mg availability in situ. This work shows that Mg accumulation in water largely increases when ionic strength (I) decreases. This phenomenon can be explained from (i) the increase of both the association equilibrium (K) and rate (ka,R) constants for the reaction between Mg cations and resin sites, and (ii) the growing contribution of the partitioning of Mg cations at the resin-gel interface, as I decreases...
October 5, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27658431/-fingolimod-effectiveness-and-safety-in-routine-clinical-practice-an-observational-retrospective-multi-centre-study-in-galicia
#14
A Pato-Pato, L Midaglia, E Costa-Arpin, A Rodriguez-Regal, A Puy-Nunez, M Rodriguez-Rodriguez, A Lopez-Real, M A Llaneza-Gonzalez, D A Garcia-Estevez, M J Moreno-Carretero, D Escriche-Jaime, M L Aguado-Valcarcel, D Munoz, J M Prieto, J R Lorenzo-Gonzalez, M C Amigo-Jorrin
INTRODUCTION: The effectiveness and safety of fingolimod in patients with relapsing-remitting multiple sclerosis (RRMS) have been proven in clinical trials. Yet, due to their limitations, it is important to know how it behaves under everyday clinical practice conditions. Hence, the aim of this study is to evaluate the effectiveness and safety of fingolimod after 12 months' usage in clinical practice in Galicia. PATIENTS AND METHODS: We conducted a retrospective, multi-centre study (n = 8) of patients with RRMS who were treated with one or more doses of fingolimod, 0...
September 5, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27611807/benefits-of-long-term-pulmonary-rehabilitation-maintenance-program-in-severe-copd-patients-3-year-follow-up
#15
Maria-Rosa Güell, Pilar Cejudo, Francisco Ortega, M Carmen Puy, Gema Rodríguez-Trigo, José Ignacio Pijoan, Lorea Martinez-Indart, Amaia Gorostiza, Khaled Bdeir, Bartolome Celli, Juan B Galdiz
INTRODUCTION: In COPD, the benefits of Pulmonary Rehabilitation (PR) tend to wane over time. Whether maintenance techniques may help sustain the benefits achieved after completion of the initial PR program remains controversial. OBJECTIVE: To determine whether a long-term (3-years) maintenance program after PR preserves the short-term effects on outcomes in patients with COPD. METHOD: This was a multi-center prospective randomized trial including 143 patients with moderate-severe COPD, with 3 years of PR maintenance following an 8-week outpatient PR program...
September 9, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27605884/polyethylene-glycols-an-effective-strategy-for-limiting-liver-ischemia-reperfusion-injury
#16
REVIEW
Gianfranco Pasut, Arnau Panisello, Emma Folch-Puy, Alexandre Lopez, Carlos Castro-Benítez, Maria Calvo, Teresa Carbonell, Agustín García-Gil, René Adam, Joan Roselló-Catafau
Liver ischemia-reperfusion injury (IRI) is an inherent feature of liver surgery and liver transplantation in which damage to a hypoxic organ (ischemia) is exacerbated following the return of oxygen delivery (reperfusion). IRI is a major cause of primary non-function after transplantation and may lead to graft rejection, regardless of immunological considerations. The immediate response involves the disruption of cellular mitochondrial oxidative phosphorylation and the accumulation of metabolic intermediates during the ischemic period, and oxidative stress during blood flow restoration...
July 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27572658/effects-of-recombinant-human-adenovirus-p53-on-the-regression-of-hepatic-fibrosis
#17
Yehong Liu, Puye Yang, Na Chen, Shumei Lin, Min Liu
Hepatic fibrosis is a scarring process that may progress to hepatic cirrhosis and even hepatic carcinoma if left untreated. Hepatic stellate cells (HSCs) play essential roles in the development of hepatic fibrosis. The tumor suppressor protein p53 is a transcription factor that is involved in cell proliferation, cell cycle regulation, apoptosis and DNA repair. Recombinant human adenovirus-p53 (Ad-p53) has been demonstrated to act as a promising antitumor gene therapy in various types of cancer. However, there is limited infomration regarding the therapeutic effect of Ad-p53 on the regression of hepatic fibrosis...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27479540/siderophores-in-cloud-waters-and-potential-impact-on-atmospheric-chemistry-production-by-microorganisms-isolated-at-the-puy-de-d%C3%A3-me-station
#18
Virginie Vinatier, Nolwenn Wirgot, Muriel Joly, Martine Sancelme, Magali Abrantes, Laurent Deguillaume, Anne-Marie Delort
A total of 450 bacteria and yeast strains isolated from cloud waters sampled at the puy de Dôme station in France (1465 m) were screened for their ability to produce siderophores. To achieve this, a high-throughput method in 96-well plates was adapted from the CAS (chrome azurol S) method. Notably, 42% of the isolates were siderophore producers. This production was examined according to the phyla of the tested strains and the type of chelating functional groups (i.e., hydroxamate, catechol, and mixed type)...
September 6, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27445797/interactions-between-flow-oscillations-and-biochemical-parameters-in-the-cerebrospinal-fluid
#19
Vincent Puy, Jadwiga Zmudka-Attier, Cyrille Capel, Roger Bouzerar, Jean-Marie Serot, Anne-Marie Bourgeois, Jérome Ausseil, Olivier Balédent
The equilibrium between the ventricular and lumbar cerebrospinal fluid (CSF) compartments may be disturbed (in terms of flow and biochemistry) in patients with chronic hydrocephalus (CH). Using flow magnetic resonance imaging (MRI) and CSF assays, we sought to determine whether changes in CSF were associated with biochemical alterations. Nine elderly patients with CH underwent phase-contrast MRI. An index of CSF dynamics (Idyn) was defined as the product of the lumbar and ventricular CSF flows. During surgery, samples of CSF were collected from the lumbar and ventricular compartments and assayed for chloride, glucose and total protein...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27433303/biomechanical-properties-of-a-novel-biodegradable-magnesium-based-interference-screw
#20
Marco Ezechieli, Hanna Meyer, Arne Lucas, Patrick Helmecke, Christoph Becher, Tilman Calliess, Henning Windhagen, Max Ettinger
Magnesium-based interference screws may be an alternative in anterior/posterior cruciate ligament reconstruction. The well-known osteoconductive effects of biodegradable magnesium alloys may be useful. It was the purpose of this study to evaluate the biomechanical properties of a magnesium based interference screw and compare it to a standard implant. A MgYREZr-alloy interference screw and a standard implant (Milagro®; De Puy Mitek, Raynham, MA, USA) were used for graft fixation. Specimens were placed into a tensile loading fixation of a servohydraulic testing machine...
June 27, 2016: Orthopedic Reviews
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