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https://www.readbyqxmd.com/read/28919067/impact-of-iron-deficiency-diagnosis-using-hepcidin-mass-spectrometry-dosage-methods-on-hospital-stay-and-costs-after-a-prolonged-icu-stay-study-protocol-for-a-multicentre-randomised-single-blinded-medico-economic-trial
#1
Sigismond Lasocki, Hervé Puy, Grégoire Mercier, Sylvain Lehmann
BACKGROUND: Iron deficiency (ID) is frequent but difficult to diagnose in critically ill patients. ID may be responsible for prolonged post-ICU hospital stays, since it results in fatigue, muscle weakness and anaemia. Hepcidin, the key iron metabolism hormone, may be a good marker of ID in these patients. The aim of this study is to determine whether using mass spectrometry hepcidin determination to diagnose (and treat) ID after prolonged ICU stays may reduce patients' subsequent hospital stays and costs in comparison with conventional (ferritin) methods...
September 14, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28874591/mutation-in-human-clpx-elevates-levels-of-%C3%AE-aminolevulinate-synthase-and-protoporphyrin-ix-to-promote-erythropoietic-protoporphyria
#2
Yvette Y Yien, Sarah Ducamp, Lisa N van der Vorm, Julia R Kardon, Hana Manceau, Caroline Kannengiesser, Hector A Bergonia, Martin D Kafina, Zoubida Karim, Laurent Gouya, Tania A Baker, Hervé Puy, John D Phillips, Gaël Nicolas, Barry H Paw
Loss-of-function mutations in genes for heme biosynthetic enzymes can give rise to congenital porphyrias, eight forms of which have been described. The genetic penetrance of the porphyrias is clinically variable, underscoring the role of additional causative, contributing, and modifier genes. We previously discovered that the mitochondrial AAA+ unfoldase ClpX promotes heme biosynthesis by activation of δ-aminolevulinate synthase (ALAS), which catalyzes the first step of heme synthesis. CLPX has also been reported to mediate heme-induced turnover of ALAS...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28873533/speciation-of-zn-fe-ca-and-mg-in-wine-with-the-donnan-membrane-technique
#3
Mireia Lao, Encarnació Companys, Liping Weng, Jaume Puy, Josep Galceran
Free concentrations of Zn(2+), Fe(3+), Ca(2+) and Mg(2+) in a red wine (Raimat, Catalonia, Spain) have been determined, with the Donnan Membrane Technique (DMT) for the first time. The required equilibration time benefits from the acceptor solution including major cations. K(+) and Na(+), mainly unbound to any ligand in the sample, have been identified as suitable reference ions. A free Zn concentration of 1.76μmolL(-1) determined with DMT was in excellent agreement with the free Zn concentration independently provided by the electroanalytical technique Absence of Gradients and Nernstian Equilibrium Stripping (AGNES), 1...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28842512/cerebral-microbleeds-and-the-risk-of-incident-ischemic-stroke-in-cadasil-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy
#4
Laurent Puy, François De Guio, Ophélia Godin, Marco Duering, Martin Dichgans, Hugues Chabriat, Eric Jouvent
BACKGROUND AND PURPOSE: Cerebral microbleeds are associated with an increased risk of intracerebral hemorrhage. Recent data suggest that microbleeds may also predict the risk of incident ischemic stroke. However, these results were observed in elderly individuals undertaking various medications and for whom causes of microbleeds and ischemic stroke may differ. We aimed to test the relationship between the presence of microbleeds and incident stroke in CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy)-a severe monogenic small vessel disease known to be responsible for both highly prevalent microbleeds and a high incidence of ischemic stroke in young patients...
August 25, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28842024/selenocystine-modified-screen-printed-electrode-as-an-alternative-sensor-for-the-voltammetric-determination-of-metal-ions
#5
Jaume Puy-Llovera, Clara Pérez-Ràfols, Núria Serrano, José Manuel Díaz-Cruz, Cristina Ariño, Miquel Esteban
A novel selenium based screen-printed electrode was developed based on the immobilization of selenocystine on aryl diazonium salt monolayers anchored to a carbon-nanofiber screen-printed electrode support (SeCyst-SPCNFE). SeCyst-SPCNFE was analytically compared to a screen-printed carbon nanofiber electrode modified with L-Cystine (Cyst-SPCNFE) for the determination of Pb(II) and Cd(II) by stripping voltammetric techniques. Their analytical performance suggests that SeCyst-SPCNFE could be a much better alternative for metal ion determination at trace levels than Cyst-SPCNFE...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28838792/vascular-cognitive-impairment-advances-and-trends
#6
REVIEW
M Barbay, H Taillia, C Nedelec-Ciceri, A Arnoux, L Puy, E Wiener, S Canaple, C Lamy, O Godefroy, M Roussel
The presence of vascular neurocognitive impairment (whatever the severity) is always associated with a functional impact and increased risk of dependency and institutionalization. However, vascular cognitive impairment remains underdiagnosed, and the mechanisms underlying post-stroke cognitive disorders are still poorly understood. However, the advent of new criteria and a standardized international neuropsychological battery is expected to lead to improved diagnosis and management, and the development of novel techniques (such as brain imaging and amyloid PET) should improve our understanding of the mechanisms underlying vascular cognitive impairment and help to identify potential targets for therapy...
August 21, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28792539/active-microorganisms-thrive-among-extremely-diverse-communities-in-cloud-water
#7
Pierre Amato, Muriel Joly, Ludovic Besaury, Anne Oudart, Najwa Taib, Anne I Moné, Laurent Deguillaume, Anne-Marie Delort, Didier Debroas
Clouds are key components in Earth's functioning. In addition of acting as obstacles to light radiations and chemical reactors, they are possible atmospheric oases for airborne microorganisms, providing water, nutrients and paths to the ground. Microbial activity was previously detected in clouds, but the microbial community that is active in situ remains unknown. Here, microbial communities in cloud water collected at puy de Dôme Mountain's meteorological station (1465 m altitude, France) were fixed upon sampling and examined by high-throughput sequencing from DNA and RNA extracts, so as to identify active species among community members...
2017: PloS One
https://www.readbyqxmd.com/read/28770457/exercise-induced-polymorphic-ventricular-tachycardia-during-treadmill-stress-test
#8
Federico G De Puy, Ayman A Farag, Vineet Kumar
No abstract text is available yet for this article.
August 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28734553/dietary-inflammatory-index-and-liver-status-in-subjects-with-different-adiposity-levels-within-the-predimed-trial
#9
Irene Cantero, Itziar Abete, Nancy Babio, Fernando Arós, Dolores Corella, Ramón Estruch, Montse Fitó, James R Hebert, M Ángel Martínez-González, Xavier Pintó, M Puy Portillo, Miguel Ruiz-Canela, Nitin Shivappa, Julia Wärnberg, Enrique Gómez-Gracia, J Antoni Tur, Jordi Salas-Salvadó, M Angeles Zulet, J Alfredo Martínez
BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted...
July 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28694661/relevance-of-proteolysis-and-proteasome-activation-in-fatty-liver-graft-preservation-an-institut-georges-lopez-1-vs-university-of-wisconsin-appraisal
#10
Mohamed Amine Zaouali, Arnau Panisello-Roselló, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Agustín García-Gil, Teresa Carbonell, René Adam, Joan Roselló-Catafau
AIM: To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions. METHODS: Fatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 °Cand subjected to "ex vivo" normo-thermic perfusion (2 h; 37 °C). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28679870/the-cytosolic-5-nucleotidase-cn-ii-lowers-the-adaptability-to-glucose-deprivation-in-human-breast-cancer-cells
#11
Gabriel Bricard, Octavia Cadassou, Laure-Estelle Cassagnes, Emeline Cros-Perrial, Léa Payen-Gay, Jean-Yves Puy, Isabelle Lefebvre-Tournier, Maria Grazia Tozzi, Charles Dumontet, Lars Petter Jordheim
The cytosolic 5'-nucleotidase cN-II is a highly conserved enzyme implicated in nucleotide metabolism. Based on recent observations suggesting additional roles not directly associated to its enzymatic activity, we studied human cancer cell models with basal or decreased cN-II expression. We developed cancer cells with stable inhibition of cN-II expression by transfection of shRNA-coding plasmids, and studied their biology. We show that human breast cancer cells MDA-MB-231 with decreased cN-II expression better adapt to the disappearance of glucose in growth medium under normoxic conditions than cells with a baseline expression level...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28656348/pap-reg3a-favors-perineural-invasion-in-pancreatic-adenocarcinoma-and-serves-as-a-prognostic-marker
#12
Jérémy Nigri, Meritxell Gironella, Christian Bressy, Elena Vila-Navarro, Julie Roques, Sophie Lac, Caroline Bontemps, Coraline Kozaczyk, Jérôme Cros, Daniel Pietrasz, Raphaël Maréchal, Jean-Luc Van Laethem, Juan Iovanna, Jean-Baptiste Bachet, Emma Folch-Puy, Richard Tomasini
Pancreatic ductal adenocarcinoma (PDA) is a fatal and insidious malignant disease for which clinicians' tools are restricted by the current limits in knowledge of how tumor and stromal cells act during the disease. Among PDA hallmarks, neural remodeling (NR) and perineural invasion (PNI) drastically influence quality of life and patient survival. Indeed, NR and PNI are associated with neuropathic pain and metastasis, respectively, both of which impact clinicians' decisions and therapeutic options. The aim of this study was to determine the impact and clinical relevance of the peritumoral microenvironment, through pancreatitis-associated protein (PAP/REG3A) expression, on PNI in pancreatic cancer...
June 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28545892/technical-feasibility-and-carbon-footprint-of-biochar-co-production-with-tomato-plant-residue
#13
Pere Llorach-Massana, Elisa Lopez-Capel, Javier Peña, Joan Rieradevall, Juan Ignacio Montero, Neus Puy
World tomato production is in the increase, generating large amounts of organic agricultural waste, which are currently incinerated or composted, releasing CO2 into the atmosphere. Organic waste is not only produced from conventional but also urban agricultural practices due recently gained popularity. An alternative to current waste management practices and carbon sequestration opportunity is the production of biochar (thermally converted biomass) from tomato plant residues and use as a soil amendment. To address the real contribution of biochar for greenhouse gas mitigation, it is necessary to assess the whole life cycle from the production of the tomato biomass feedstock to the actual distribution and utilisation of the biochar produced in a regional context...
May 22, 2017: Waste Management
https://www.readbyqxmd.com/read/28534353/subcutaneous-versus-intravenous-administration-of-trastuzumab-preference-of-her2-breast-cancer-patients-and-financial-impact-of-its-use
#14
Andrea Lazaro Cebas, Susana Cortijo Cascajares, Siria Pablos Bravo, Maria Del Puy Goyache Goñi, Gema Gonzalez Monterrubio, Maria Dolores Perez Cardenas, Jose Miguel Ferrari Piquero
PURPOSE: To investigate the preference of HER2+ breast cancer patients and nursing professionals for subcutaneous (SC) versus intravenous (IV) trastuzumab and to evaluate the financial impact derived from the use of the SC formulation. METHODS: A cross-sectional questionnaire-based study was carried out to investigate preferences of all patients who started treatment with SC trastuzumab while they had received the IV formulation before. The preference of nursing staff in charge of preparation and administration was also analysed...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28533320/electrocardiogram-challenge-syncope-in-a-woman-with-nausea-and-diarrhea
#15
Federico De Puy, G Neal Kay
No abstract text is available yet for this article.
May 23, 2017: Circulation
https://www.readbyqxmd.com/read/28516737/iron-status-and-inflammatory-biomarkers-in-patients-with-acutely-decompensated-heart-failure-early-in-hospital-phase-and-30-day-follow-up
#16
Lucas N L Van Aelst, Marjorie Abraham, Malha Sadoune, Thibaud Lefebvre, Philippe Manivet, Damien Logeart, Jean-Marie Launay, Zoubida Karim, Hervé Puy, Alain Cohen-Solal
No abstract text is available yet for this article.
May 17, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28508621/extending-the-use-of-diffusive-gradients-in-thin-films-dgt-to-solutions-where-competition-saturation-and-kinetic-effects-are-not-negligible
#17
Martín Jiménez-Piedrahita, Alexandra Altier, Joan Cecilia, Jaume Puy, Josep Galceran, Carlos Rey-Castro, Hao Zhang, William Davison
DGT (Diffusion Gradients in Thin films) was designed to sample trace metals in situ at their natural concentrations. The setup and the experimental deployment conditions were established to allow interpretation of a linear accumulation of metal with time, using a simple expression based on a steady-state flux under perfect sink conditions. However, the extension of DGT to a wide range of analytes and its use under varied conditions has shown that, in some situations, these conditions are not fulfilled, so that accumulations with time are nonlinear...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28467383/polyphenol-levels-are-inversely-correlated-with-body-weight-and-obesity-in-an-elderly-population-after-5-years-of-follow-up-the-randomised-predimed-study
#18
Xiaohui Guo, Anna Tresserra-Rimbau, Ramón Estruch, Miguel A Martínez-González, Alexander Medina-Remón, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó, Maria Puy Portillo, Juan J Moreno, Xavier Pi-Sunyer, Rosa M Lamuela-Raventós
Overweight and obesity have been steadily increasing in recent years and currently represent a serious threat to public health. Few human studies have investigated the relationship between polyphenol intake and body weight. Our aim was to assess the relationship between urinary polyphenol levels and body weight. A cross-sectional study was performed with 573 participants from the PREDIMED (Prevención con Dieta Mediterránea) trial (ISRCTN35739639). Total polyphenol levels were measured by a reliable biomarker, total urinary polyphenol excretion (TPE), determined by the Folin-Ciocalteu method in urine samples...
May 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28415014/determination-and-quantification-of-intracellular-fludarabine-triphosphate-cladribine-triphosphate-and-clofarabine-triphosphate-by-lc-ms-ms-in-human-cancer-cells
#19
Jean-Yves Puy, Lars Petter Jordheim, Emeline Cros-Perrial, Charles Dumontet, Suzanne Peyrottes, Isabelle Lefebvre-Tournier
Purine nucleoside analogues are widely used in the treatment of haematological malignancies, and their biological activity is dependent on the intracellular accumulation of their triphosphorylated metabolites. In this context, we developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to study the formation of 5'-triphosphorylated derivatives of cladribine, fludarabine, clofarabine and 2'-deoxyadenosine in human cancer cells. Br-ATP was used as internal standard. Separation was achieved on a hypercarb column...
May 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28408624/activated-protein-c-inhibits-neutrophil-extracellular-trap-formation-in-vitro-and-activation-in-vivo
#20
Laura D Healy, Cristina Puy, José A Fernández, Annachiara Mitrugno, Ravi S Keshari, Nyiawung A Taku, Tiffany T Chu, Xiao Xu, András Gruber, Florea Lupu, John H Griffin, Owen J T McCarty
Activated protein C (APC) is a multifunctional serine protease with anticoagulant, cytoprotective, and anti-inflammatory activities. In addition to the cytoprotective effects of APC on endothelial cells, podocytes, and neurons, APC cleaves and detoxifies extracellular histones, a major component of neutrophil extracellular traps (NETs). NETs promote pathogen clearance but also can lead to thrombosis; the pathways that negatively regulate NETosis are largely unknown. Thus, we studied whether APC is capable of directly inhibiting NETosis via receptor-mediated cell signaling mechanisms...
May 26, 2017: Journal of Biological Chemistry
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