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Jeremy S Abramson
No abstract text is available yet for this article.
October 25, 2016: Leukemia & Lymphoma
Miri Danan-Gotthold, Clotilde Guyon, Matthieu Giraud, Erez Y Levanon, Jakub Abramson
BACKGROUND: In order to become functionally competent but harmless mediators of the immune system, T cells undergo a strict educational program in the thymus, where they learn to discriminate between self and non-self. This educational program is, to a large extent, mediated by medullary thymic epithelial cells that have a unique capacity to express, and subsequently present, a large fraction of body antigens. While the scope of promiscuously expressed genes by medullary thymic epithelial cells is well-established, relatively little is known about the expression of variants that are generated by co-transcriptional and post-transcriptional processes...
October 24, 2016: Genome Biology
Chhavi Raj Bhatt, Mary Redmayne, Baki Billah, Michael J Abramson, Geza Benke
The aim of this study was to assess environmental and personal radiofrequency-electromagnetic field (RF-EMF) exposures in kindergarten children. Ten children and 20 kindergartens in Melbourne, Australia participated in personal and environmental exposure measurements, respectively. Order statistics of RF-EMF exposures were computed for 16 frequency bands between 88 MHz and 5.8 GHz. Of the 16 bands, the three highest sources of environmental RF-EMF exposures were: Global System for Mobile Communications (GSM) 900 MHz downlink (82 mV/m); Universal Mobile Telecommunications System (UMTS) 2100MHz downlink (51 mV/m); and GSM 900 MHz uplink (45 mV/m)...
October 19, 2016: Journal of Exposure Science & Environmental Epidemiology
Lauren B Alloy, Jessica L Hamilton, Elissa J Hamlat, Lyn Y Abramson
Adolescence marks the emergence of sex differences in internalizing symptoms and disorders, with girls at increased risk for depression and anxiety during the pubertal transition. However, the mechanisms through which puberty confers risk for internalizing psychopathology for girls, but not boys, remain unclear. We examined two pubertal indicators (pubertal status and timing) as predictors of the development of emotion regulation styles (rumination and emotional clarity) and depressive and anxiety symptoms and disorders in a three-wave study of 314 adolescents...
September 2016: Clinical Psychological Science
Bradley W Abramson, Benjamin Kachel, David M Kramer, Daniel C Ducat
In plants, a limited capacity to utilize or export the end products of the Calvin Benson cycle (CB) from photosynthetically-active source cells to non-photosynthetic sink cells can result in reduced carbon capture, photosynthetic electron transport (PET) and lowered photochemical efficiency. The downregulation of photosynthesis caused by reduced capacity to utilize photosynthate has been termed "sink limitation". Recently, several cyanobacterial and algal strains engineered to over-produce target metabolites have exhibited increased photochemistry suggesting possible source-sink regulatory mechanisms may be involved...
October 13, 2016: Plant & Cell Physiology
G Bowatt, C J Lodge, A J Lowe, B Erbas, J Perret, M J Abramson, M C Matheson, S C Dharmage
No abstract text is available yet for this article.
September 25, 2016: Allergy
Sandrine Isaac, Jose U Scher, Ana Djukovic, Nuria Jiménez, Dan R Littman, Steven B Abramson, Eric G Pamer, Carles Ubeda
BACKGROUND: Oral vancomycin remains the mainstay of therapy for severe infections produced by Clostridium difficile, the most prevalent cause of healthcare-associated infectious diarrhoea in developed countries. However, its short- and long-term effects on the human intestinal microbiota remain largely unknown. METHODS: We utilized high-throughput sequencing to analyse the effects of vancomycin on the faecal human microbiota up to 22 weeks post-antibiotic cessation...
October 5, 2016: Journal of Antimicrobial Chemotherapy
Stina Syrjänen, Jaana Rautava, Kari Syrjänen
The interesting history of papillomavirus (PV) research has been reviewed before. The history of human papillomavirus (HPV) in head and neck region starts in 1901 when the contagious transmission of warty lesions into the mouth via oral sex was described, although the confirmation of their viral etiology had to wait until 1907. Ullman was the first to associate the human wart virus with laryngeal warts. Parsons and Kidd described the natural history of oral PV infections in rabbits already in 1942, but these findings were corroborated in humans only recently...
2017: Recent Results in Cancer Research
Olga Katsara, Mukundan Attur, Rachel Ruoff, Steven B Abramson, Victoria Kolupaeva
Objectives Degeneration of articular cartilage is central to OA pathology; however, the molecular mechanisms leading to these irreversible changes are still poorly understood. Here, we investigated how changes in the chondrocyte translational apparatus may contribute to the pathology of OA. Methods Normal and OA human knee cartilage was used to analyze the activity of different components of the translational machinery. Chondrocytes isolated from lesional and non-lesional areas of OA cartilage were used to estimate relative rate of protein synthesis by metabolic labeling...
October 1, 2016: Arthritis & Rheumatology
Jasmine H Francis, Ariana M Levin, David H Abramson
PURPOSE: The aim of this study was to review peer-reviewed articles on ophthalmic oncology (specifically retinoblastoma and uveal melanoma) published from January to December 2014. DESIGN: This study is a literature review. METHODS: The terms retinoblastoma and uveal melanoma were used in a MEDLINE literature search. Abstracts were studied, and the most relevant articles were selected for inclusion and further in-depth review. RESULTS: In retinoblastoma, more eyes are being salvaged due to intravitreal melphalan...
September 2016: Asia-Pacific Journal of Ophthalmology
Charles I Abramson, Christopher W Dinges, Harrington Wells
The honey bee has been an important model organism for studying learning and memory. More recently, the honey bee has become a valuable model to understand perception and cognition. However, the techniques used to explore psychological phenomena in honey bees have been limited to only a few primary methodologies such as the proboscis extension reflex, sting extension reflex, and free flying target discrimination-tasks. Methods to explore operant conditioning in bees and other invertebrates are not as varied as with vertebrates...
2016: PloS One
Cunlan Guo, Xi Yu, Sivan Refaely-Abramson, Lior Sepunaru, Tatyana Bendikov, Israel Pecht, Leeor Kronik, Ayelet Vilan, Mordechai Sheves, David Cahen
Charge migration for electron transfer via the polypeptide matrix of proteins is a key process in biological energy conversion and signaling systems. It is sensitive to the sequence of amino acids composing the protein and, therefore, offers a tool for chemical control of charge transport across biomaterial-based devices. We designed a series of linear oligoalanine peptides with a single tryptophan substitution that acts as a "dopant," introducing an energy level closer to the electrodes' Fermi level than that of the alanine homopeptide...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
Connie Duer, Tom Tomasi, Charles I Abramson
Even in the best situations, the artificial social constructs of captivity alter natural elephant behavior and unfortunately create distress. Asian elephants are powerful and intelligent animals that require consideration for their well-being and prudent management. The males present particular difficulties due to a temporary state of heightened aggressive behavior unique to male elephants called "musth." When he is in this state, the danger the elephant poses to other animals and the people around him is considerable...
September 12, 2016: Psychological Reports
Paula Schaiquevich, Armida W Fabius, Jasmine H Francis, Guillermo L Chantada, David H Abramson
PURPOSE: To review preclinical and clinical pharmacokinetic studies of the three most important chemotherapy drugs used for intraocular retinoblastoma and the contribution of the reported results to optimize treatment. METHODS: Systemic review of pharmacokinetic studies identified by a literature search at Pubmed using the keywords carboplatin, melphalan, topotecan, intravitreal, ophthalmic artery chemosurgery, pharmacokinetics, and retinoblastoma. RESULTS: A total of 21 studies were reviewed for assessing the preclinical and clinical pharmacokinetics of carboplatin, topotecan, and melphalan delivered by intravenous, periocular, ophthalmic artery, and intravitreal routes...
September 8, 2016: Retina
Jasmine Jomichen, Sonia El-Zaemey, Jane S Heyworth, Renee N Carey, Ellie Darcey, Alison Reid, Deborah C Glass, Tim Driscoll, Susan Peters, Michael Abramson, Lin Fritschi
BACKGROUND: Pesticides are widely used in some occupational settings. Some pesticides have been classified as carcinogens; however, data on the number of workers exposed to pesticides are not available in Australia. The main aim of this study was to estimate the current prevalence of pesticide exposure in Australian workplaces. METHODS: The analysis used data from the Australian Work Exposures Study, a series of nationwide telephone surveys which investigated work-related prevalence and exposure to carcinogens and asthmagens, including pesticides, among current Australian workers...
September 8, 2016: Occupational and Environmental Medicine
Shatha A Alduraywish, Marie Standl, Caroline J Lodge, Michael J Abramson, Katrina J Allen, Bircan Erbas, Andrea von Berg, Joachim Heinrich, Adrian J Lowe, Shyamali C Dharmage
BACKGROUND: The march from early aeroallergen sensitization to subsequent respiratory allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. OBJECTIVE: To assess the association between food sensitization in the first 2 years of life and subsequent asthma and allergic rhinitis by age 10-12 years. METHODS: We used data from two independent cohorts: the high-risk Melbourne Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus (n = 3094)...
September 3, 2016: Pediatric Allergy and Immunology
Chhavi Raj Bhatt, Arno Thielens, Baki Billah, Mary Redmayne, Michael J Abramson, Malcolm R Sim, Roel Vermeulen, Luc Martens, Wout Joseph, Geza Benke
The purposes of this study were: i) to demonstrate the assessment of personal exposure from various RF-EMF sources across different microenvironments in Australia and Belgium, with two on-body calibrated exposimeters, in contrast to earlier studies which employed single, non-on-body calibrated exposimeters; ii) to systematically evaluate the performance of the exposimeters using (on-body) calibration and cross-talk measurements; and iii) to compare the exposure levels measured for one site in each of several selected microenvironments in the two countries...
August 30, 2016: Environmental Research
Steven M Horwitz, Andrew D Zelenetz, Leo I Gordon, William G Wierda, Jeremy S Abramson, Ranjana H Advani, C Babis Andreadis, Nancy Bartlett, John C Byrd, Luis E Fayad, Richard I Fisher, Martha J Glenn, Thomas M Habermann, Nancy Lee Harris, Francisco Hernandez-Ilizaliturri, Richard T Hoppe, Mark S Kaminski, Christopher R Kelsey, Youn H Kim, Susan Krivacic, Ann S LaCasce, Matthew Lunning, Auayporn Nademanee, Oliver Press, Rachel Rabinovitch, Nishitha Reddy, Erin Reid, Kenneth Roberts, Ayman A Saad, Lubomir Sokol, Lode J Swinnen, Julie M Vose, Joachim Yahalom, Nadeem Zafar, Mary Dwyer, Hema Sundar, Pierluigi Porcu
Peripheral T-cell lymphomas (PTCLs) represent a relatively uncommon heterogeneous group of non-Hodgkin's lymphomas (NHLs) with an aggressive clinical course and poor prognosis. Anthracycline-based multiagent chemotherapy with or without radiation therapy followed by first-line consolidation with high-dose therapy followed by autologous stem cell rescue (HDT/ASCR) is the standard approach to most of the patients with newly diagnosed PTCL. Relapsed or refractory disease is managed with second-line systemic therapy followed by HDT/ASCR or allogeneic stem cell transplant, based on the patient's eligibility for transplant...
September 2016: Journal of the National Comprehensive Cancer Network: JNCCN
Shyamali C Dharmage, Jennifer L Perret, John A Burgess, Caroline J Lodge, David P Johns, Paul S Thomas, Graham G Giles, John L Hopper, Michael J Abramson, E Haydn Walters, Melanie C Matheson
BACKGROUND AND OBJECTIVE: Personal smoking is widely regarded to be the primary cause of chronic bronchitis (CB) in adults, but with limited knowledge of contributions by other factors, including current asthma. We aimed to estimate the independent and relative contributions to adult CB from other potential influences spanning childhood to middle age. METHODS: The population-based Tasmanian Longitudinal Health Study cohort, people born in 1961, completed respiratory questionnaires and spirometry in 1968 (n=8,583)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Amanda O'Brien, Ralf W Schlosser, Howard C Shane, Jennifer Abramson, Anna A Allen, Suzanne Flynn, Christina Yu, Katherine Dimery
Using augmented input might be an effective means for supplementing spoken language for children with autism who have difficulties following spoken directives. This study aimed to (a) explore whether JIT-delivered scene cues (photos, video clips) via the Apple Watch(®) enable children with autism to carry out directives they were unable to implement with speech alone, and (b) test the feasibility of the Apple Watch(®) (with a focus on display size). Results indicated that the hierarchical JIT supports enabled five children with autism to carry out the majority of directives...
August 29, 2016: Journal of Autism and Developmental Disorders
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