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https://www.readbyqxmd.com/read/28511038/attributable-risks-of-emergency-hospital-visits-due-to-air-pollutants-in-china-a-multi-city-study
#1
Gongbo Chen, Yongming Zhang, Wenyi Zhang, Shanshan Li, Gail Williams, Guy B Marks, Bin Jalaludin, Michael J Abramson, Fengming Luo, Dong Yang, Xin Su, Qichang Lin, Laiyu Liu, Jiangtao Lin, Yuming Guo
Air pollution is associated with risks of mortality in China, but the evidence is still limited for morbidity. This study aims to examine overall effects of ambient air pollutants on emergency hospital visits (EHVs) at the national level in China and calculate corresponding attributable risks. We collected daily data for EHVs from 33 largest hospitals in China between Oct 2013 and Dec 2014, as well as daily measurements of particulate matter (PM10 and PM2.5: particles with aerodynamic diameter < 10 μm and 2...
May 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28505483/the-effects-of-ingested-aqueous-aluminum-on-floral-fidelity-and-foraging-strategy-in-honey-bees-apis-mellifera
#2
Ana M Chicas-Mosier, Bree A Cooper, Alexander M Melendez, Melina Pérez, Devrim Oskay, Charles I Abramson
Pollinator decline is of international concern because of the economic services these organisms provide. Commonly cited sources of decline are toxicants, habitat fragmentation, and parasites. Toxicant exposure can occur through uptake and distribution from plant tissues and resources such as pollen and nectar. Metals such as aluminum can be distributed to pollinators and other herbivores through this route especially in acidified or mined areas. A free-flying artificial flower patch apparatus was used to understand how two concentrations of aluminum (2mg/L and 20mg/L) may affect the learning, orientation, and foraging behaviors of honey bees (Apis mellifera) in Turkey...
May 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28481326/the-dose-response-association-between-nitrogen-dioxide-exposure-and-serum-interleukin-6-concentrations
#3
Jennifer L Perret, Gayan Bowatte, Caroline J Lodge, Luke D Knibbs, Lyle C Gurrin, Rangi Kandane-Rathnayake, David P Johns, Adrian J Lowe, John A Burgess, Bruce R Thompson, Paul S Thomas, Richard Wood-Baker, Stephen Morrison, Graham G Giles, Guy Marks, James Markos, Mimi L K Tang, Michael J Abramson, E Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
Systemic inflammation is an integral part of chronic obstructive pulmonary disease (COPD), and air pollution is associated with cardiorespiratory mortality, yet the interrelationships are not fully defined. We examined associations between nitrogen dioxide (NO₂) exposure (as a marker of traffic-related air pollution) and pro-inflammatory cytokines, and investigated effect modification and mediation by post-bronchodilator airflow obstruction (post-BD-AO) and cardiovascular risk. Data from middle-aged participants in the Tasmanian Longitudinal Health Study (TAHS, n = 1389) were analyzed by multivariable logistic regression, using serum interleukin (IL)-6, IL-8 and tumor necrosis factor-α (TNF-α) as the outcome...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28447828/gender-differences-in-depression-in-representative-national-samples-meta-analyses-of-diagnoses-and-symptoms
#4
Rachel H Salk, Janet S Hyde, Lyn Y Abramson
In 2 meta-analyses on gender differences in depression in nationally representative samples, we advance previous work by including studies of depression diagnoses and symptoms to (a) estimate the magnitude of the gender difference in depression across a wide array of nations and ages; (b) use a developmental perspective to elucidate patterns of gender differences across the life span; and (c) incorporate additional theory-driven moderators (e.g., gender equity). For major depression diagnoses and depression symptoms, respectively, we meta-analyzed data from 65 and 95 articles and their corresponding national data sets, representing data from 1,716,195 and 1,922,064 people in over 90 different nations...
April 27, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28445962/psma-homing-dsrna-chimeric-protein-vector-kills-prostate-cancer-cells-and-activates-anti-tumor-bystander-responses
#5
Yael Langut, Nufar Edinger, Efrat Flashner-Abramson, Naomi Melamed-Book, Mario Lebendiker, Yael Levi-Kalisman, Shoshana Klein, Alexander Levitzki
The treatment of metastatic androgen-resistant prostate cancer remains a challenge. We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on the surface of prostate cancer cells.The chimeric protein is built from the double stranded RNA (dsRNA) binding domain of PKR tethered to a single chain anti-PSMA antibody. When complexed with polyIC, the chimera demonstrates selective and efficient killing of prostate cancer cells...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28442138/the-role-of-personal-values-in-children-s-costly-sharing-and-non-costly-giving
#6
Lior Abramson, Ella Daniel, Ariel Knafo-Noam
This study examined whether children's values, global and abstract motivations serving as guiding principles, are organized similarly to those of adults, whether values can predict individual differences in children's sharing behaviors, and whether the normative nature of the situation influences the expression of these individual differences. Children (N=243, ages 5-12years) participated in a values ranking task as part of a visit to a science museum. The majority of children (n=150) also participated in a task examining costly sharing (i...
April 22, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28420794/structural-features-and-lipid-binding-domain-of-tubulin-on-biomimetic-mitochondrial-membranes
#7
David P Hoogerheide, Sergei Y Noskov, Daniel Jacobs, Lucie Bergdoll, Vitalii Silin, David L Worcester, Jeff Abramson, Hirsh Nanda, Tatiana K Rostovtseva, Sergey M Bezrukov
Dimeric tubulin, an abundant water-soluble cytosolic protein known primarily for its role in the cytoskeleton, is routinely found to be associated with mitochondrial outer membranes, although the structure and physiological role of mitochondria-bound tubulin are still unknown. There is also no consensus on whether tubulin is a peripheral membrane protein or is integrated into the outer mitochondrial membrane. Here the results of five independent techniques-surface plasmon resonance, electrochemical impedance spectroscopy, bilayer overtone analysis, neutron reflectometry, and molecular dynamics simulations-suggest that α-tubulin's amphipathic helix H10 is responsible for peripheral binding of dimeric tubulin to biomimetic "mitochondrial" membranes in a manner that differentiates between the two primary lipid headgroups found in mitochondrial membranes, phosphatidylethanolamine and phosphatidylcholine...
May 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28420644/smokers-and-postcessation-weight-gain-after-acute-coronary-syndrome
#8
Payam Dehghani, Bettina Habib, Sarah B Windle, Nathalie Roy, Wayne Old, François R Grondin, Iqbal Bata, Ayman Iskander, Claude Lauzon, Nalin Srivastava, Adam Clarke, Daniel Cassavar, Danielle Dion, Herbert Haught, Shamir R Mehta, Jean-François Baril, Charles Lambert, Mina Madan, Beth L Abramson, Mark J Eisenberg
BACKGROUND: Smoking cessation and weight management are recommended after acute coronary syndrome (ACS); however, little is known about the effects of smoking cessation on weight change after ACS. We aimed to assess the effect of smoking cessation after ACS on weight over a 12-month follow-up period. METHODS AND RESULTS: Data were prospectively collected from the EVITA (Evaluation of Varenicline in Smoking Cessation for Patients Post-Acute Coronary Syndrome) trial...
April 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28400579/water-carbon-dioxide-solid-phase-equilibria-at-pressures-above-4-gpa
#9
E H Abramson, O Bollengier, J M Brown
A solid phase in the mixed water-carbon dioxide system, previously identified as carbonic acid, was observed in the high-pressure diamond-anvil cell. The pressure-temperature paths of both its melting and peritectic curves were measured, beginning at 4.4 GPa and 165 °C (where it exists in a quadruple equilibrium, together with an aqueous fluid and the ices H2O(VII) and CO2(I)) and proceeding to higher pressures and temperatures. Single-crystal X-ray diffraction revealed a triclinic crystal with unit cell parameters (at 6...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28399037/ocular-argyrosis-mimicking-conjunctival-melanoma
#10
Irwin Tendler, Melissa P Pulitzer, Victor Roggli, David H Abramson, Brian P Marr
PURPOSE: To present a novel case of ocular argyrosis mimicking conjunctival melanoma. METHODS: A 48-year-old man who is a jewelry manufacturer presented with raised pigmented lesions in the inferior fornices of both eyes. Brown-black colored, follicle-like, masses were observed in both fornices. RESULTS: An incisional biopsy confirmed the presence of silver and the diagnosis of ocular argyrosis. CONCLUSIONS: Despite its limited negative health effects, ocular argyrosis should be considered in the differential diagnosis of conjunctival pigmented lesions because of the potential for misidentification of neoplastic growth...
June 2017: Cornea
https://www.readbyqxmd.com/read/28396346/photoaffinity-labeling-with-cholesterol-analogues-precisely-maps-a-cholesterol-binding-site-in-voltage-dependent-anion-channel-1
#11
Melissa M Budelier, Wayland Wl Cheng, Lucie Bergdoll, Zi-Wei Chen, James W Janetka, Jeff Abramson, Kathiresan Krishnan, Laurel Mydock-McGrane, Douglas F Covey, Julian P Whitelegge, Alex S Evers
Voltage-dependent anion channel-1 (VDAC1) is a highly regulated β-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell. VDAC1 co-purifies with cholesterol and is functionally regulated by cholesterol, among other endogenous lipids. Molecular modeling studies based on NMR observations have suggested five cholesterol-binding sites in VDAC1, but direct experimental evidence for these sites is lacking. Here, to determine the sites of cholesterol binding, we photolabeled purified mouse VDAC1 (mVDAC1) with photoactivatable cholesterol analogues and analyzed the photolabeled sites with both top-down mass spectrometry (MS), and bottom-up MS paired with a clickable, stable isotope labeled tag, FLI-tag...
April 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28390496/kindling-of-life-stress-in-bipolar-disorder-effects-of-early-adversity
#12
Benjamin G Shapero, Rachel B Weiss, Taylor A Burke, Elaine M Boland, Lyn Y Abramson, Lauren B Alloy
Most theoretical frameworks regarding the role of life stress in bipolar disorders (BD) do not incorporate the possibility of a changing relationship between psychosocial context and episode initiation across the course of the disorder. The kindling hypothesis theorizes that over the longitudinal course of recurrent affective disorders, the relationship between major life stressors and episode initiation declines (Post, 1992). The present study aimed to test an extension of the kindling hypothesis in BD by examining the effect of early life adversity on the relationship between proximal life events and prospectively assessed mood episodes...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28390495/aggression-protects-against-the-onset-of-major-depressive-episodes-in-individuals-with-bipolar-spectrum-disorder
#13
Tommy H Ng, Rachel D Freed, Madison K Titone, Jonathan P Stange, Rachel B Weiss, Lyn Y Abramson, Lauren B Alloy
A growing body of research suggests that bipolar spectrum disorders (BSDs) are associated with high aggression. However, little research has prospectively examined how aggression may affect time to onset of hypomanic/manic versus major depressive episodes. In a longitudinal study, we tested the hypothesis that aggression would prospectively predict a shorter time to the onset of hypomanic/manic episodes and a longer time to the onset of major depressive episodes, based on the behavioral approach system theory of BSDs...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28379322/international-working-group-consensus-response-evaluation-criteria-in-lymphoma-recil-2017
#14
A Younes, P Hilden, B Coiffier, A Hagenbeek, G Salles, W Wilson, J F Seymour, K Kelly, J Gribben, M Pfreunschuh, F Morschhauser, H Schoder, A D Zelenetz, J Rademaker, R Advani, N Valente, C Fortpied, T E Witzig, L H Sehn, A Engert, R I Fisher, P-L Zinzani, M Federico, M Hutchings, C Bollard, M Trneny, Y A Elsayed, K Tobinai, J S Abramson, N Fowler, A Goy, M Smith, S Ansell, J Kuruvilla, M Dreyling, C Thieblemont, R F Little, I Aurer, M H J Van Oers, K Takeshita, A Gopal, S Rule, S de Vos, I Kloos, M S Kaminski, M Meignan, L H Schwartz, J P Leonard, S J Schuster, V E Seshan
In recent years, the number of approved and investigational agents that can be safely administered for the treatment of lymphoma patients for a prolonged period of time has substantially increased. Many of these novel agents are evaluated in early-phase clinical trials in patients with a wide range of malignancies, including solid tumors and lymphoma. Furthermore, with the advances in genome sequencing, new "basket" clinical trial designs have emerged that select patients based on the presence of specific genetic alterations across different types of solid tumors and lymphoma...
April 3, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28369451/association-between-birthweight-and-later-body-mass-index-an-individual-based-pooled-analysis-of-27-twin-cohorts-participating-in-the-codatwins-project
#15
Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietiläinen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, Toos Cem van Beijsterveldt, Syuichi Ooki, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Kauko Heikkilä, Tessa L Cutler, John L Hopper, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth Jf Loos, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, S Alexandra Burt, Kelly L Klump, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire Ma Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Robert F Krueger, Matt McGue, Shandell Pahlen, Dorret I Boomsma, Thorkild Ia Sørensen, Jaakko Kaprio, Karri Silventoinen
Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries...
March 19, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28368159/personality-disorder-symptom-severity-predicts-onset-of-mood-episodes-and-conversion-to-bipolar-i-disorder-in-individuals-with-bipolar-spectrum-disorder
#16
Tommy H Ng, Taylor A Burke, Jonathan P Stange, Patricia D Walshaw, Rachel B Weiss, Snezana Urosevic, Lyn Y Abramson, Lauren B Alloy
Although personality disorders (PDs) are highly comorbid with bipolar spectrum disorders (BSDs), little longitudinal research has been conducted to examine the prospective impact of PD symptoms on the course of BSDs. The aim of this study is to examine whether PD symptom severity predicts shorter time to onset of bipolar mood episodes and conversion to bipolar I disorder over time among individuals with less severe BSDs. Participants (n = 166) with bipolar II disorder, cyclothymia, or bipolar disorder not otherwise specified completed diagnostic interview assessments of PD symptoms and self-report measures of mood symptoms at baseline...
April 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28362516/reply-to-bias-in-association-between-fev1-fvc-predicted-at-7-years-and-asthma-copd-overlap-syndrome
#17
Dinh S Bui, John A Burgess, Minh Bui, Michael J Abramson, E Haydn Walters, Shyamali C Dharmage
No abstract text is available yet for this article.
March 31, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28355232/a-genome-wide-trans-ethnic-interaction-study-links-the-pigr-fcamr-locus-to-coronary-atherosclerosis-via-interactions-between-genetic-variants-and-residential-exposure-to-traffic
#18
Cavin K Ward-Caviness, Lucas M Neas, Colette Blach, Carol S Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Z Elaine Dowdy, Robert B Devlin, David Diaz-Sanchez, Wayne E Cascio, Marie Lynn Miranda, Simon G Gregory, Svati H Shah, William E Kraus, Elizabeth R Hauser
Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic-related air pollution is a widespread environmental exposure and is associated with multiple cardiovascular outcomes such as coronary atherosclerosis, peripheral arterial disease, and myocardial infarction. Despite the recognition of the importance of both genetic and environmental exposures to the pathogenesis of cardiovascular disease, studies of how these two contributors operate jointly are rare. We performed a genome-wide interaction study (GWIS) to examine gene-traffic exposure interactions associated with coronary atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28352656/trafficking-receptor-signatures-define-blood-plasmablasts-responding-to-tissue-specific-immune-challenge
#19
Yekyung Seong, Nicole H Lazarus, Lusijah Sutherland, Aida Habtezion, Tzvia Abramson, Xiao-Song He, Harry B Greenberg, Eugene C Butcher
Antibody-secreting cells are generated in regional lymphoid tissues and traffic as plasmablasts (PBs) via lymph and blood to target sites for local immunity. We used multiparameter flow cytometry to define PB trafficking programs (TPs, combinations of adhesion molecules and chemoattractant receptors) and their imprinting in patients in response to localized infection or immune insults. TPs enriched after infection or autoimmune inflammation of mucosae correlate with sites of immune response or symptoms, with different TPs imprinted during small intestinal, colon, throat, and upper respiratory immune challenge...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28346034/evidence-of-binaural-integration-benefits-following-aria-training-for-children-and-adolescents-diagnosed-with-amblyaudia
#20
Deborah Moncrieff, William Keith, Maria Abramson, Alicia Swann
OBJECTIVE: The purpose of this study was to demonstrate the efficacy of Auditory Rehabilitation for Interaural Asymmetry (ARIA) to improve dichotic listening scores in children and adolescents diagnosed with amblyaudia and other binaural integration deficits. DESIGN: The study is a field experiment without randomisation. STUDY: Participants placed into groups based on dichotic listening test scores received four sessions of ARIA training. Baseline scores were compared to performance during the final session of training and to scores obtained 2 or more months after completion of ARIA...
March 27, 2017: International Journal of Audiology
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