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https://www.readbyqxmd.com/read/29468242/electronic-structure-of-dipeptides-in-the-gas-phase-and-as-an-adsorbed-monolayer
#1
Cunlan Guo, Soumyajit Sarkar, Sivan Refaely-Abramson, David A Egger, Tatyana Bendikov, Keiichirou Yonezawa, Yosuke Suda, Takuma Yamaguchi, Israel Pecht, Satoshi Kera, Nobuo Ueno, Mordechai Sheves, Leeor Kronik, David Cahen
Peptide-based molecular electronic devices are promising due to the large diversity and unique electronic properties of biomolecules. These electronic properties can change considerably with peptide structure, allowing diverse design possibilities. In this work, we explore the effect of the side-chain of the peptide on its electronic properties, by using both experimental and computational tools to detect the electronic energy levels of two model peptides. The peptides include 2Ala and 2Trp as well as their 3-mercaptopropionic acid linker which is used to form monolayers on an Au surface...
February 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29467271/correction-to-imitation-of-novel-conspecific-and-human-speech-sounds-in-the-killer-whale-orcinus-orca
#2
J Z Abramson, M V Hernández-Lloreda, L García, F Colmenares, F Aboitiz, J Call
No abstract text is available yet for this article.
February 28, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29467204/the-role-of-air-pollution-and-lung-function-in-cognitive-impairment
#3
Anke Hüls, Andrea Vierkötter, Dorothea Sugiri, Michael J Abramson, Ulrich Ranft, Ursula Krämer, Tamara Schikowski
Air pollution has been associated with impaired lung and cognitive function, especially impairment in visuo-construction performance (VCP). In this article, we evaluate whether the effect of air pollution on VCP is mediated by lung function.We used data from the SALIA cohort (baseline 1985-1994 and follow-up 2007-2010) including 587 women aged 55 years at baseline. Particulate matter (PM) and nitrogen dioxide (NO2 ) exposures at baseline were estimated via land-use regression models. Lung function was characterised by averages between baseline and follow-up...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29448048/scholarly-activity-training-during-residency-are-we-hitting-the-mark-a-national-assessment-of-pediatric-residents
#4
Erika L Abramson, Monique M Naifeh, Michelle D Stevenson, Elizabeth Mauer, Hoda T Hammad, Linda M Gerber, Su-Ting T Li
OBJECTIVE: Participation in scholarly activity (SA) is an ACGME requirement. Yet, the authors' previous research with program directors (PDs) suggests pediatric SA training is variable and suboptimal. To help programs better meet requirements, our objective was to understand the resident perspective regarding SA training, including factors associated with satisfaction and productivity. METHODS: The authors conducted cross-sectional surveys of second and third year pediatric residents and PDs at 22 diverse programs in 2016...
February 12, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29443558/reducing-disparities-in-adolescent-pregnancy-among-us-tribal-youths
#5
Kendra King Bowes, Barri B Burrus, Sarah Axelson, Milagros Garrido, Adriana Kimbriel, Lisa Abramson, Gwenda Gorman, Angela Dancer, Terrill White, P J Beaudry
No abstract text is available yet for this article.
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29440449/impact-of-the-anti-cancer-drug-nt157-on-tyrosine-kinase-signalling-networks
#6
Shih-Ping Su, Efrat Flashner-Abramson, Shoshana Klein, Mor Gal, Rachel S Lee, Jianmin Wu, Alexander Levitzki, Roger J Daly
The small molecule drug NT157 has demonstrated promising efficacy in pre-clinical models of a number of different cancer types, reflecting activity against both cancer cells and the tumour microenvironment. Two known mechanisms of action are degradation of insulin-receptor substrates (IRS)-1/2, and reduced Stat3 activation, although it is possible that others exist. In order to interrogate the effects of this drug on cell signalling pathways in an unbiased manner, we have undertaken mass spectrometry-based global tyrosine phosphorylation profiling of NT157-treated A375 melanoma cells...
February 12, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29431361/statins-in-persons-at-low-risk-of-cardiovascular-disease
#7
John Abramson
No abstract text is available yet for this article.
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29427878/traffic-related-air-pollution-and-development-and-persistence-of-asthma-and-low-lung-function
#8
Gayan Bowatte, Caroline J Lodge, Luke D Knibbs, Bircan Erbas, Jennifer L Perret, Bin Jalaludin, Geoffrey G Morgan, Dinh S Bui, Graham G Giles, Garun S Hamilton, Richard Wood-Baker, Paul Thomas, Bruce R Thompson, Melanie C Matheson, Michael J Abramson, E Haydn Walters, Shyamali C Dharmage
BACKGROUND AND AIMS: Traffic Related Air Pollution (TRAP) exposure is known to exacerbate existing respiratory diseases. We investigated longer term effects of TRAP exposure for individuals with or without existing asthma, and with or without lower lung function. METHODS: Associations between TRAP exposure and asthma (n = 689) and lung function (n = 599) were investigated in the prospective Tasmanian Longitudinal Health Study (TAHS). TRAP exposure at age 45 years was measured using two methods based on residential address: mean annual NO2 exposure; and distance to nearest major road...
February 7, 2018: Environment International
https://www.readbyqxmd.com/read/29427697/barriers-and-strategies-for-oral-medication-adherence-among-children-and-adolescents-with-type-2-diabetes
#9
E M Venditti, K Tan, N Chang, L Laffel, G McGinley, N Miranda, J B Tryggestad, N Walders-Abramson, P Yasuda, L Delahanty
AIMS: Examine barriers for taking glucose-lowering oral medications, associated baseline characteristics, strategies used, and the adherence impact in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. METHODS: We studied youth prescribed oral diabetes medications over two years (N = 611, 583, and 525 at 6, 12, and 24 months). Clinicians documented barriers (e.g. forgetting, routines, other concerns) in the subsample that reported missed doses (N=423 [69...
February 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29421471/gender-matters-in-cardiac-rehabilitation-and-diabetes-using-bourdieu-s-concepts
#10
Jan E Angus, Craig M Dale, Lisa Seto Nielsen, Marnie Kramer-Kile, Jennifer Lapum, Cheryl Pritlove, Beth Abramson, Jennifer A Price, Susan Marzolini, Paul Oh, Alex Clark
BACKGROUND: Habitual practices are challenged by chronic illness. Cardiac rehabilitation (CR) involves changes to habits of diet, activity and tobacco use, and although it is effective for people with diabetes and cardiovascular disease (CVD), some participants are reportedly less likely to complete programs and adopt new health related practices. Within the first three months of enrolling in CR, attrition rates are highest for women and for people with diabetes. Previous studies and reviews indicate that altering habits is very difficult, and the social significance of such change requires further study...
January 6, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29411446/factors-associated-with-nicotine-replacement-therapy-use-among-hospitalised-smokers
#11
Chang Yue Chui, Dennis Thomas, Simone Taylor, Billie Bonevski, Michael J Abramson, Eldho Paul, Susan G Poole, Gregory R Weeks, Michael J Dooley, Johnson George
INTRODUCTION AND AIMS: Nicotine replacement therapy (NRT) is recommended as a smoking cessation aid for hospitalised smokers. We examined factors associated with NRT use during hospitalisation and after discharge, and NRT uptake when systematically offered free of cost. DESIGN AND METHODS: A nested analysis was conducted using data from a clinical trial that evaluated the effectiveness of a pharmacist-led smoking cessation intervention in 600 hospitalised smokers...
February 7, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29392936/long-lived-correlated-triplet-pairs-in-a-%C3%AF-stacked-crystalline-pentacene-derivative
#12
Brendan D Folie, Jonah B Haber, Sivan Refaely-Abramson, Jeffrey B Neaton, Naomi S Ginsberg
Singlet fission is the spin-conserving process by which a singlet exciton splits into two triplet excitons. Singlet fission occurs via a correlated triplet pair intermediate, but direct evidence of this state has been scant, and in films of TIPS-pentacene, a small molecule organic semiconductor, even the rate of fission has been unclear. We use polarization-resolved transient absorption microscopy on individual crystalline domains of TIPS-pentacene to establish the fission rate and demonstrate that the initially created triplets remain bound for a surprisingly long time, hundreds of picoseconds, before separating...
February 2, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29389462/the-expanding-role-of-antimicrobial-stewardship-programs-in-hospitals-in-the-united-states-lessons-learned-from-a-multisite-qualitative-study
#13
Shashi N Kapadia, Erika L Abramson, Eileen J Carter, Angela S Loo, Rainu Kaushal, David P Calfee, Matthew S Simon
BACKGROUND: Misuse of antibiotics can lead to the development of antibiotic resistance, which adversely affects morbidity, mortality, length of stay, and cost. To combat the threat of antimicrobial resistance, The Joint Commission and the Centers for Medicare & Medicaid Services have initiated or proposed requirements for hospitals to have antimicrobial stewardship programs (ASPs), but implementation remains challenging. A key-informant interview study was conducted to describe the characteristics and innovative strategies of leading ASPs...
February 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29386364/imitation-of-novel-conspecific-and-human-speech-sounds-in-the-killer-whale-orcinus-orca
#14
José Z Abramson, Mª Victoria Hernández-Lloreda, Lino García, Fernando Colmenares, Francisco Aboitiz, Josep Call
Vocal imitation is a hallmark of human spoken language, which, along with other advanced cognitive skills, has fuelled the evolution of human culture. Comparative evidence has revealed that although the ability to copy sounds from conspecifics is mostly uniquely human among primates, a few distantly related taxa of birds and mammals have also independently evolved this capacity. Remarkably, field observations of killer whales have documented the existence of group-differentiated vocal dialects that are often referred to as traditions or cultures and are hypothesized to be acquired non-genetically...
January 31, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29376375/probing-charge-transport-through-peptide-bonds
#15
Joseph Murphy Brisendine, Sivan Refaely-Abramson, Zhen-Fei Liu, Jing Cui, Fay Ng, Jeffrey B Neaton, Ronald L Koder, Latha Venkataraman
We measure the conductance of unmodified peptides at the single molecule level using the scanning tunneling microscope-based break-junction method, utilizing the N-terminal amine group and the C-terminal carboxyl group as gold metal-binding linkers. Our conductance measurements of oligoglycine and oligoalanine backbones do not rely on peptide side-chain linkers. We compare our results with alkanes terminated asymmetrically with an amine group on one end and a carboxyl group on the other to show that peptide bonds decrease the conductance of an otherwise saturated carbon chain...
January 27, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29364118/robust-multicontrast-mri-spleen-segmentation-for-splenomegaly-using-multi-atlas-segmentation
#16
Yuankai Huo, Jiaqi Liu, Zhoubing Xu, Robert L Harrigan, Albert Assad, Richard G Abramson, Bennett A Landman
OBJECTIVE: Magnetic resonance imaging (MRI) is an essential imaging modality in noninvasive splenomegaly diagnosis. However, it is challenging to achieve spleen volume measurement from three-dimensional MRI given the diverse structural variations of human abdomens as well as the wide variety of clinical MRI acquisition schemes. Multi-atlas segmentation (MAS) approaches have been widely used and validated to handle heterogeneous anatomical scenarios. In this paper, we propose to use MAS for clinical MRI spleen segmentation for splenomegaly...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29332123/braf-nras-and-gnaq-mutations-in-conjunctival-melanocytic-nevi
#17
Jasmine H Francis, Hans E Grossniklaus, Larissa A Habib, Brian Marr, David H Abramson, Klaus J Busam
Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi. Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. One lesion with negative immunoreactivity and for all blue nevi, a hybridization capture-based next-generation sequencing method was employed for mutation analysis...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331087/outdoor-pollen-is-a-trigger-of-child-and-adolescent-asthma-ed-presentations-a-systematic-review-and-meta-analysis
#18
REVIEW
Bircan Erbas, Mitra Jazayeri, Katrina A Lambert, Constance H Katelaris, Luke A Prendergast, Rachel Tham, M Jeannette Parrodi, Janet Davies, Ed Newbigin, Michael J Abramson, Shyamali C Dharmage
BACKGROUND: In the context of increased asthma exacerbations associated with climatic changes such as thunderstorm asthma, interest in establishing the link between pollen exposure and asthma hospital admissions has intensified. Here, we systematically reviewed and performed a meta-analysis of studies on pollen and ED attendance. METHODS: A search for studies with appropriate search strategy in Medline, Embase, Web of Science and CINAHL was conducted. Each study was assessed for quality and risk of bias...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29328724/origins-of-singlet-fission-in-solid-pentacene-from-an-ab%C3%A2-initio-green-s-function-approach
#19
Sivan Refaely-Abramson, Felipe H da Jornada, Steven G Louie, Jeffrey B Neaton
We develop a new first-principles approach to predict and understand rates of singlet fission with an ab initio Green's-function formalism based on many-body perturbation theory. Starting with singlet and triplet excitons computed from a GW plus Bethe-Salpeter equation approach, we calculate the exciton-biexciton coupling to lowest order in the Coulomb interaction, assuming a final state consisting of two noninteracting spin-correlated triplets with finite center-of-mass momentum. For crystalline pentacene, symmetries dictate that the only purely Coulombic fission decay process from a bright singlet state requires a final state consisting of two inequivalent nearly degenerate triplets of nonzero, equal and opposite, center-of-mass momenta...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29327909/more-on-anti-cd19-car-t-cells-in-cns-diffuse-large-b-cell-lymphoma
#20
Jeremy S Abramson, Yi-Bin Chen
No abstract text is available yet for this article.
November 23, 2017: New England Journal of Medicine
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