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https://www.readbyqxmd.com/read/29678453/latex-glove-use-among-healthcare-workers-in-australia
#1
Renee N Carey, Lin Fritschi, Timothy R Driscoll, Michael J Abramson, Deborah C Glass, Ellie Darcey, Si Si, Geza Benke, Alison Reid, Sonia El-Zaemey
BACKGROUND: Exposure to natural rubber latex, primarily through the use of gloves, is a well-recognized cause of occupational asthma. We investigated latex glove use among Australian workers and estimated the resultant burden of occupational asthma among healthcare workers (HCWs). METHODS: Data were collected in 2014 as part of the Australian Work Exposures Study-Asthma, a telephone survey investigating the prevalence of current occupational exposure to asthmagens, including latex...
April 17, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29674730/birth-size-and-gestational-age-in-opposite-sex-twins-as-compared-to-same-sex-twins-an-individual-based-pooled-analysis-of-21-cohorts
#2
Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon-Mi Hur, Vilhelmina Ullemar, Catarina Almqvist, Patrik Ke Magnusson, Gonneke Willemsen, Meike Bartels, Catharina Em van Beijsterveldt, Leonie H Bogl, Kirsi H Pietiläinen, Eero Vuoksimaa, Fuling Ji, Feng Ning, Zengchang Pang, Tracy L Nelson, Keith E Whitfield, Esther Rebato, Clare H Llewellyn, Abigail Fisher, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, Syuichi Ooki, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Tessa L Cutler, John L Hopper, Robert F Krueger, Matt McGue, Shandell Pahlen, Jeffrey M Craig, Richard Saffery, Claire Ma Haworth, Robert Plomin, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Robert F Vlietinck, Catherine A Derom, Ruth Jf Loos, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), including 67,850 dizygotic twin individuals. Linear regression analyses showed that boys having a co-twin sister were, on average, 31 g (95% CI 18 to 45) heavier and 0...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29668412/on-quality-metrics-and-quantitative-imaging
#3
Richard G Abramson
No abstract text is available yet for this article.
May 2018: Radiology
https://www.readbyqxmd.com/read/29656171/associations-between-birth-size-and-later-height-from-infancy-through-adulthood-an-individual-based-pooled-analysis-of-28-twin-cohorts-participating-in-the-codatwins-project
#4
Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Yoon-Mi Hur, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Syuichi Ooki, Vilhelmina Ullemar, Catarina Almqvist, Patrik K E Magnusson, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Tessa L Cutler, John L Hopper, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Robert F Krueger, Matt McGue, Shandell Pahlen, S Alexandra Burt, Kelly L Klump, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Gonneke Willemsen, Meike Bartels, Catharina E M van Beijsterveld, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Kauko Heikkilä, Kirsi H Pietiläinen, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire M A Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Jina Kim, Jooyeon Lee, Sooji Lee, Joohon Sung, Ruth J F Loos, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries...
April 12, 2018: Early Human Development
https://www.readbyqxmd.com/read/29653349/the-role-of-lifetime-anxiety-history-in-the-course-of-bipolar-spectrum-disorders
#5
Madison K Titone, Rachel D Freed, Jared K O'Garro-Moore, Andrew Gepty, Tommy H Ng, Jonathan P Stange, Lyn Y Abramson, Lauren B Alloy
Individuals with bipolar spectrum disorder (BSD) frequently meet criteria for comorbid anxiety disorders, and anxiety may be an important factor in the etiology and course of BSDs. The current study examined the association of lifetime anxiety disorders with prospective manic/hypomanic versus major depressive episodes. Participants were 244 young adults (aged 17-26) with milder forms of BSDs (i.e., bipolar-II, cyclothymia, BD-NOS). First, bivariate analyses assessed differences in baseline clinical characteristics between participants with and without DSM-IV anxiety diagnoses...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29629819/efficacy-and-safety-of-anti-trop-2-antibody-drug-conjugate-sacituzumab-govitecan-immu-132-in-heavily-pretreated-patients-with-metastatic-triple-negative-breast-cancer
#6
Aditya Bardia, Ingrid A Mayer, Jennifer R Diamond, Rebecca L Moroose, Steven J Isakoff, Alexander N Starodub, Nikita C Shah, Joyce O'Shaughnessy, Kevin Kalinsky, Michael Guarino, Vandana Abramson, Dejan Juric, Sara M Tolaney, Jordan Berlin, Wells A Messersmith, Allyson J Ocean, William A Wegener, Pius Maliakal, Robert M Sharkey, Serengulam V Govindan, David M Goldenberg, Linda T Vahdat
Purpose Trop-2, expressed in most triple-negative breast cancers (TNBCs), may be a potential target for antibody-drug conjugates. Sacituzumab govitecan, an antibody-drug conjugate, targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan. Patients and Methods We evaluated sacituzumab govitecan in a single-arm, multicenter trial in patients with relapsed/refractory metastatic TNBC who received a 10 mg/kg starting dose on days 1 and 8 of 21-day repeated cycles. The primary end points were safety and objective response rate; secondary end points were progression-free survival and overall survival...
June 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29628376/childhood-predictors-of-lung-function-trajectories-and-future-copd-risk-a-prospective-cohort-study-from-the-first-to-the-sixth-decade-of-life
#7
Dinh S Bui, Caroline J Lodge, John A Burgess, Adrian J Lowe, Jennifer Perret, Minh Q Bui, Gayan Bowatte, Lyle Gurrin, David P Johns, Bruce R Thompson, Garun S Hamilton, Peter A Frith, Alan L James, Paul S Thomas, Deborah Jarvis, Cecilie Svanes, Melissa Russell, Stephen C Morrison, Iain Feather, Katrina J Allen, Richard Wood-Baker, John Hopper, Graham G Giles, Michael J Abramson, Eugene H Walters, Melanie C Matheson, Shyamali C Dharmage
BACKGROUND: Lifetime lung function is related to quality of life and longevity. Over the lifespan, individuals follow different lung function trajectories. Identification of these trajectories, their determinants, and outcomes is important, but no study has done this beyond the fourth decade. METHODS: We used six waves of the Tasmanian Longitudinal Health Study (TAHS) to model lung function trajectories measured at 7, 13, 18, 45, 50, and 53 years. We analysed pre-bronchodilator FEV1 z-scores at the six timepoints using group-based trajectory modelling to identify distinct subgroups of individuals whose measurements followed a similar pattern over time...
April 5, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29621434/isocyanates-in-australia-current-exposure-to-an-old-hazard
#8
Sonia El Zaemey, Deborah Glass, Lin Fritschi, Ellie Darcey, Renee Carey, Tim Driscoll, Michael Abramson, Si Si, Geza Benke, Alison Reid
Exposure to isocyanates has consistently been reported as the most common cause of occupational asthma. The objectives of this study were to assess how many Australian workers are currently exposed to isocyanates, identify the occupations with highest proportion of exposed workers and identify the main circumstances of exposures. Data comes from the Australian Workplace Exposure Study-Asthma, a national telephone survey which explored the prevalence of current occupational exposure to 227 asthmagens, grouped into 27 groups, among current Australian workers aged 18-65 years...
April 5, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29618007/subphenotype-meta-analysis-of-testicular-cancer-genome-wide-association-study-data-suggests-a-role-for-rbfox-family-genes-in-cryptorchidism-susceptibility
#9
Yanping Wang, Dione R Gray, Alan K Robbins, Erin L Crowgey, Stephen J Chanock, Mark H Greene, Katherine A McGlynn, Katherine Nathanson, Clare Turnbull, Zhaoming Wang, Marcella Devoto, Julia Spencer Barthold
STUDY QUESTION: Can subphenotype analysis of genome-wide association study (GWAS) data from subjects with testicular germ cell tumor (TGCT) provide insight into cryptorchidism (undescended testis, UDT) susceptibility? SUMMARY ANSWER: Suggestive intragenic GWAS signals common to UDT, TGCT case-case and TGCT case-control analyses occur in genes encoding RBFOX RNA-binding proteins (RBPs) and their neurodevelopmental targets. WHAT IS KNOWN ALREADY: UDT is a strong risk factor for TGCT, but while genetic risk factors for TGCT are well-known, genetic susceptibility to UDT is poorly understood and appears to be more complex...
March 29, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29596098/a-dedicated-acute-pain-service-is-associated-with-reduced-postoperative-opioid-requirements-in-patients-undergoing-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#10
Engy T Said, Jacklynn F Sztain, Wendy B Abramson, Minhthy N Meineke, Timothy J Furnish, Ulrich H Schmidt, Gerard R Manecke, Rodney A Gabriel
BACKGROUND: The Acute Pain Service (APS) was initially introduced to optimize multimodal postoperative pain control. The aim of this study was to evaluate the association between the implementation of an APS and postoperative pain management and outcomes for patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). METHODS: In this propensity-matched retrospective cohort study, we performed a before-after study without a concurrent control group...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29587425/radiofrequency-electromagnetic-radiation-and-memory-performance-sources-of-uncertainty-in-epidemiological-cohort-studies
#11
REVIEW
Christopher Brzozek, Kurt K Benke, Berihun M Zeleke, Michael J Abramson, Geza Benke
Uncertainty in experimental studies of exposure to radiation from mobile phones has in the past only been framed within the context of statistical variability. It is now becoming more apparent to researchers that epistemic or reducible uncertainties can also affect the total error in results. These uncertainties are derived from a wide range of sources including human error, such as data transcription, model structure, measurement and linguistic errors in communication. The issue of epistemic uncertainty is reviewed and interpreted in the context of the MoRPhEUS, ExPOSURE and HERMES cohort studies which investigate the effect of radiofrequency electromagnetic radiation from mobile phones on memory performance...
March 26, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29581161/smoking-abstinence-1-year-after-acute-coronary-syndrome-follow-up-from-a-randomized-controlled-trial-of-varenicline-in-patients-admitted-to-hospital
#12
Sarah B Windle, Payam Dehghani, Nathalie Roy, Wayne Old, François R Grondin, Iqbal Bata, Ayman Iskander, Claude Lauzon, Nalin Srivastava, Adam Clarke, Daniel Cassavar, Danielle Dion, Herbert Haught, Shamir R Mehta, Jean-François Baril, Charles Lambert, Mina Madan, Beth L Abramson, Mark J Eisenberg
BACKGROUND: Patients who continue to smoke after acute coronary syndrome are at increased risk of reinfarction and death. We previously found use of varenicline to increase abstinence 24 weeks after acute coronary syndrome; here we report results through 52 weeks. METHODS: The EVITA trial was a multicentre, double-blind, randomized, placebo-controlled trial of varenicline for smoking cessation in patients admitted to hospital with acute coronary syndrome. Participants were randomly assigned (1:1) to receive varenicline or placebo for 12 weeks, in conjunction with low-intensity counselling...
March 26, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29571419/women-and-peripheral-arterial-disease-a-review-of-sex-differences-in-epidemiology-clinical-manifestations-and-outcomes
#13
REVIEW
Kajenny Srivaratharajah, Beth L Abramson
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in women. Peripheral arterial disease (PAD), a manifestation of CVD and a marker for other adverse CVD outcomes such as ischemic heart disease and stroke, remains underrecognized and undertreated in women. Contrary to the previous belief that PAD is mainly a disease of white men, contemporary data suggest equal, if not higher, prevalence rates in nonwhite women. Women often present with asymptomatic or atypical disease and seek medical attention with more advanced disease...
April 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29570895/repeatability-reproducibility-and-accuracy-of-quantitative-mri-of-the-breast-in-the-community-radiology-setting
#14
Anna G Sorace, Chengyue Wu, Stephanie L Barnes, Angela M Jarrett, Sarah Avery, Debra Patt, Boone Goodgame, Jeffery J Luci, Hakmook Kang, Richard G Abramson, Thomas E Yankeelov, John Virostko
BACKGROUND: Quantitative diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) have the potential to impact patient care by providing noninvasive biological information in breast cancer. PURPOSE/HYPOTHESIS: To quantify the repeatability, reproducibility, and accuracy of apparent diffusion coefficient (ADC) and T1 -mapping of the breast in community radiology practices. STUDY TYPE: Prospective. SUBJECTS/PHANTOM: Ice-water DW-MRI and T1 gel phantoms were used to assess accuracy...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29566869/clinicopathologic-correlation-of-choroidal-invasion-in-retinoblastoma
#15
David H Abramson, Robert Folberg, Jasmine H Francis
No abstract text is available yet for this article.
April 2018: Ophthalmology
https://www.readbyqxmd.com/read/29564165/a-kras-wild-type-mutational-status-confers-a-survival-advantage-in-pancreatic-ductal-adenocarcinoma
#16
Annika L Windon, Arturo Loaiza-Bonilla, Christopher E Jensen, Michael Randall, Jennifer J D Morrissette, Stuti G Shroff
Background: The KRAS oncogene is a driver mutation and is present in greater than 90% of pancreatic ductal adenocarcinomas (PDAC). A subset of these tumors, however, do not harbor mutations in KRAS (wild type KRAS ). Studies have shown that patients with mutated KRAS have a poorer survival on first-line gemcitabine-based chemotherapy compared to wild type KRAS . In this study, we examined a cohort of patients with PDAC at our institution who were either wild type or mutant for the KRAS gene and assessed for differences in survival and response to different chemotherapeutic regimens...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29560611/childhood-measles-contributes-to-post-bronchodilator-airflow-obstruction-in-middle-aged-adults-a-cohort-study
#17
Jennifer L Perret, Melanie C Matheson, Lyle C Gurrin, David P Johns, John A Burgess, Bruce R Thompson, Adrian J Lowe, James Markos, Stephen S Morrison, Christine F McDonald, Richard Wood-Baker, Cecilie Svanes, Paul S Thomas, John L Hopper, Graham G Giles, Michael J Abramson, E Haydn Walters, Shyamali C Dharmage
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) has potential origins in childhood but an association between childhood measles and post-bronchodilator (BD) airflow obstruction (AO) has not yet been shown. We investigated whether childhood measles contributed to post-BD AO through interactions with asthma and/or smoking in a non-immunized middle-aged population. METHODS: The population-based Tasmanian Longitudinal Health Study (TAHS) cohort born in 1961 (n = 8583) underwent spirometry in 1968 before immunization was introduced...
March 20, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29558313/case-256
#18
Amanda M Eisenberg, Christine N Eppelheimer, Tamara A Fulop, Lisa L Abramson
No abstract text is available yet for this article.
April 2018: Radiology
https://www.readbyqxmd.com/read/29513055/intravitreal-chemotherapy-and-laser-for-newly-visible-subretinal-seeds-in-retinoblastoma
#19
David H Abramson, Federica Catalanotti, Scott E Brodie, Michael G Kellick, Jasmine H Francis
BACKGROUND: There has been no effective method for treating newly visible ("new") subretinal seeding in retinoblastoma except enucleation. The objective of this report is to determine whether intravitreal chemotherapy combined with 810 nm indirect laser can successfully treat retinoblastoma eyes with "new" subretinal seeding which appeared after intra-arterial chemotherapy (ophthalmic arterial chemosurgery: OAC). MATERIAL AND METHODS: Single center retrospective study from a tertiary cancer hospital of a case series of 14 eyes treated with combined intravitreal chemotherapy and laser from 2012 to 2017...
March 7, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29511941/the-modification-of-cell-wall-properties-by-expression-of-recombinant-resilin-in-transgenic-plants
#20
Itan Preis, Miron Abramson, Oded Shoseyov
Plant tissue is composed of many different types of cells. Plant cells required to withstand mechanical pressure, such as vessel elements and fibers, have a secondary cell wall consisting of polysaccharides and lignin, which strengthen the cell wall structure and stabilize the cell shape. Previous attempts to alter the properties of the cell wall have mainly focused on reducing the amount of lignin or altering its structure in order to ease its extraction from raw woody materials for the pulp and paper and biorefinery industries...
March 6, 2018: Molecular Biotechnology
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