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https://www.readbyqxmd.com/read/29684669/the-impact-of-associated-injuries-and-fracture-classifications-on-the-treatment-of-capitellum-and-trochlea-fractures-a-systematic-review-and-meta-analysis
#1
REVIEW
Shu-Kun He, Long Xu, Jin-Hai Guo, Jing-Ping Liao, Ting-Wu Qin, Fu-Guo Huang
BACKGROUND: Capitellum and trochlea fractures are truly rare and the treatment is not fully appreciated. So we evaluate the impact of associated injuries and fracture classifications on elbow functional outcomes after open reduction and internal fixation. MATERIALS AND METHODS: PubMed, Embase, Ovid Medline, and the Cochrane Library were searched from January 1, 1974 to January 1, 2017. All English literature with the treatment of capitellum and trochlea fractures by open reduction and internal fixation were included...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684666/systematic-review-of-preservation-solutions-for-allografts-for-liver-transplantation-based-on-a-network-meta-analysis
#2
REVIEW
Fengying Rao, Jian Yang, Cheng Gong, Rong Huang, Qi Wang, Jun Shen
AIMS: The aim of this work was to determine the best preservation solutions for allografts for liver transplantation by quantitative network meta-analysis. METHODS: Global electronic databases including PubMed, EMBASE, and Cochrane Library were searched for relevant randomized controlled trials. Seven pieces of parametric data were extracted from included studies for pooled estimation. A consistency model was used for direct and indirect comparisons. The cumulative probability P value was utilized to rank the solutions...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684489/analysis-of-the-microrna-transcriptome-of-daphnia-pulex-during-aging
#3
Jiabao Hu, Chongyuan Lin, Mengdi Liu, Qiaoqiong Tong, Shanliang Xu, Danli Wang, Yunlong Zhao
Daphnia pulex is an important food organism that exhibits a particular mode of reproduction known as cyclical parthenogenesis (asexual) and sexual reproduction. Regulation of the aging process by microRNAs (miRNAs) is a research hotspot in miRNA studies. To investigate a possible role of miRNAs in regulating aging and senescence, we used Illumina HiSeq to sequence two miRNA libraries from 1-day-old (1d) and 25-day-old (25d) D. pulex specimens. In total, we obtained 11,218,097 clean reads and 28,569 unique miRNAs from 1d specimens and 11,819,106 clean reads and 44,709 unique miRNAs from 25d specimens...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29684288/endobronchial-ultrasound-for-nodal-staging-of-non-small-cell-lung-cancer-patients-with-radiologically-normal-mediastinum-a-meta-analysis
#4
Hazem El-Osta, Pushan Jani, Ali Mansour, Philip Rascoe, Syed Jafri
RATIONALE: An accurate assessment of the mediastinal lymph nodes status is essential in the staging and treatment planning of potentially resectable non-small cell lung cancer (NSCLC). OBJECTIVES: We performed this meta-analysis to evaluate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in detecting occult mediastinal disease in NSCLC with no radiologic mediastinal involvement. METHODS: The PubMed, Embase, and Cochrane libraries were searched for studies describing the role of EBUS-TBNA in lung cancer patients with radiologically negative mediastinum...
April 23, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29684250/electronic-medication-administration-records-in-long-term-care-facilities-a-scoping-review
#5
REVIEW
Andrew E C Fuller, Lisa M Guirguis, Cheryl A Sadowski, Mark J Makowsky
OBJECTIVES: To map the extent, range, and nature of research on the effectiveness, level of use, and perceptions about electronic medication administration records (eMARs) in long-term care facilities (LTCFs) and identify gaps in current knowledge and priority areas for future research. DESIGN: Scoping review of quantitative and qualitative literature. SETTING: Literature review. PARTICIPANTS: Original research relating to eMAR in LTCF was eligible for inclusion...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29684190/can-online-social-support-be-detrimental-in-stigmatized-chronic-diseases-a-quadratic-model-of-the-effects-of-informational-and-emotional-support-on-self-care-behavior-of-hiv-patients
#6
Xunyi Wang, Srikanth Parameswaran, Darshan Mahendra Bagul, Rajiv Kishore
Objective: We studied the impact of online social support on patient self-care behavior in an online health community for human immunodeficiency virus (HIV) patients. We conceptualized emotional and informational support provided by community members into nuanced sub-dimensions. We explored how the direct and interaction effects of these sub-dimensions impact the self-care behavior of a support seeker. Methods: We used data from 330 255 posts in 30 050 threads from POZ, an online health community for HIV patients...
April 18, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29684023/in-vivo-insertion-pool-sequencing-identifies-virulence-factors-in-a-complex-fungal-host-interaction
#7
Simon Uhse, Florian G Pflug, Alexandra Stirnberg, Klaus Ehrlinger, Arndt von Haeseler, Armin Djamei
Large-scale insertional mutagenesis screens can be powerful genome-wide tools if they are streamlined with efficient downstream analysis, which is a serious bottleneck in complex biological systems. A major impediment to the success of next-generation sequencing (NGS)-based screens for virulence factors is that the genetic material of pathogens is often underrepresented within the eukaryotic host, making detection extremely challenging. We therefore established insertion Pool-Sequencing (iPool-Seq) on maize infected with the biotrophic fungus U...
April 2018: PLoS Biology
https://www.readbyqxmd.com/read/29683493/dna-encoded-chemical-libraries-achievements-and-remaining-challenges
#8
REVIEW
Nicholas Favalli, Gabriele Bassi, Jörg Scheuermann, Dario Neri
DNA-encoded chemical libraries (DECLs) are collections of compounds, individually coupled to DNA tags serving as amplifiable identification barcodes. Since individual compounds can be identified by the associated DNA tag, they can be stored as a mixture, allowing the synthesis and screening of combinatorial libraries of unprecedented size, facilitated by the implementation of split&pool synthetic procedures or other experimental methodologies. In this review, we briefly present relevant concepts and technologies, which are required for the implementation and interpretation of screening procedures with DNA-encoded chemical libraries...
April 23, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29683449/optimizing-the-genetic-incorporation-of-chemical-probes-into-gpcrs-for-photo-crosslinking-mapping-and-bioorthogonal-chemistry-in-live-mammalian-cells
#9
Robert Serfling, Lisa Seidel, Thore Böttke, Irene Coin
The genetic incorporation of non-canonical amino acids (ncAAs) via amber stop codon suppression is a powerful technique to install artificial probes and reactive moieties onto proteins directly in the live cell. Each ncAA is incorporated by a dedicated orthogonal suppressor-tRNA/amino-acyl-tRNA-synthetase (AARS) pair that is imported into the host organism. The incorporation efficiency of different ncAAs can greatly differ, and be unsatisfactory in some cases. Orthogonal pairs can be improved by manipulating either the AARS or the tRNA...
April 9, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683381/pseudouridines-have-context-dependent-mutation-and-stop-rates-in-high-throughput-sequencing
#10
Katherine I Zhou, Wesley C Clark, David W Pan, Matthew J Eckwahl, Qing Dai, Tao Pan
The abundant RNA modification pseudouridine (Ψ) has been mapped transcriptome-wide by chemically modifying pseudouridines with carbodiimide and detecting the resulting reverse transcription stops in high-throughput sequencing. However, these methods have limited sensitivity and specificity, in part due to the use of reverse transcription stops. We sought to use mutations rather than just stops in sequencing data to identify pseudouridine sites. Here, we identify reverse transcription conditions that allow read-through of carbodiimide-modified pseudouridine (CMC-Ψ), and we show that pseudouridines in carbodiimide-treated human ribosomal RNA have context-dependent mutation and stop rates in high-throughput sequencing libraries prepared under these conditions...
April 23, 2018: RNA Biology
https://www.readbyqxmd.com/read/29683322/furoxans-oxadiazole-4n-oxides-with-attenuated-reactivity-are-neuroprotective-cross-the-blood-brain-barrier-and-improve-passive-avoidance-memory
#11
Austin Horton, Kevin Nash, Ethel Tackie-Yarboi, Alexander Kostrevski, Adam Novak, Aparna Raghavan, Jatin Tulsulkar, Qasim Alhadidi, Nathan Wamer, Bryn Langenderfer, Kalee Royster, Maxwell Ducharme, Katelyn Hagood, Megan Post, Zahoor A Shah, Isaac T Schiefer
Nitric oxide (NO) mimetics and other agents capable of enhancing NO/cGMP signaling have demonstrated efficacy as potential therapies for Alzheimer's disease. A group of thiol-dependent NO mimetics known as furoxans may be designed to exhibit attenuated reactivity to provide slow onset NO effects. The present study describes the design, synthesis, and evaluation of a furoxan library resulting in the identification of a prototype furoxan, 5a, which was profiled for use in the CNS. 5a demonstrated negligible reactivity toward generic cellular thiols under physiological conditions...
April 23, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29683269/multiple-machine-learning-based-chemoinformatics-models-for-identification-of-histone-acetyl-transferase-inhibitors
#12
Shagun Krishna, Sushil Kumar, Deependra Kumar Singh, Amar Deep Lakra, Dibyendu Banerjee, Mohammad Imran Siddiqi
The histone acetyl transferase (HAT) are involved in acetylation of histones that lead to transcription activation in numerous gene regulatory mechanisms. There are very few GCN5 HAT inhibitors reported despite of their role in cancer progression. In this study, we have utilized in-silico virtual screening approaches based on various machine learning algorithm to identify potent inhibitors of GCN5 HAT from commercially available Maybridge library. We have generated predictive chemoinformatics models based on k-Nearest neighbour, naïve Bayesian, Random Forest and Support Vector Machine...
April 23, 2018: Molecular Informatics
https://www.readbyqxmd.com/read/29683066/identification-of-circulating-micrornas-as-diagnostic-biomarkers-for-ovarian-cancer-a-pooled-analysis-of-individual-studies
#13
Quan Zhou, Man-Zhen Zuo, Ze He, Hai-Rong Li, Wei Li
BACKGROUND: Circulating microRNAs (miRNAs) are proposed as promising non-invasive diagnostic biomarkers for many cancers. However, the diagnostic value of circulating miRNAs in ovarian cancer is inconsistent in different studies. Thus we performed this meta-analysis to systematically evaluate the diagnostic value of circulating miRNAs in ovarian cancer. METHODS: Eligible studies that were published prior to 30 June 2017 were searched from the PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29682791/prevalence-of-refractive-errors-in-children-in-india-a-systematic-review
#14
REVIEW
Sethu Sheeladevi, Bharani Seelam, Phanindra B Nukella, Aditi Modi, Rahul Ali, Lisa Keay
Uncorrected refractive error is an avoidable cause of visual impairment which affects children in India. The objective of this review is to estimate the prevalence of refractive errors in children ≤ 15 years of age. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in this review. A detailed literature search was performed to include all population and school-based studies published from India between January 1990 and January 2017, using the Cochrane Library, Medline and Embase...
April 22, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29682718/-meta-analysis-for-high-risk-factor-of-anastomotic-leakage-after-anal-preserving-surgery-for-rectal-cancer
#15
Yingjiang Ye, Hongpeng Jiang
OBJECTIVE: To systematically evaluate the effect of defunctioning stoma, preoperative radiotherapy, and level of inferior mesenteric artery (IMA) ligation on the postoperative anastomotic leakage in rectal cancer by meta-analysis. METHODS: Randomized controlled trials (RCT) published before December 2017 regarding the effects of defunctioning stoma, preoperative radiotherapy, and level of inferior mesenteric artery ligation on the postoperative anastomotic leakage in rectal cancer were searched from PubMed, Embase, Scopus, Cochrane Library, CNKI, Wanfang database, meanwhile open data in unpublished trials from clinicaltrials...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682699/effects-of-continuous-positive-airway-pressure-on-cardiovascular-biomarkers-in-patients-with-obstructive-sleep-apnea-a-meta-analysis-of-randomized-controlled-trials
#16
Yu Ning, Tian-Song Zhang, Wan-Wan Wen, Kun Li, Yun-Xiao Yang, Yan-Wen Qin, Hui-Na Zhang, Yun-Hui Du, Lin-Yi Li, Song Yang, Yun-Yun Yang, Miao-Miao Zhu, Xiao-Lu Jiao, Yan Zhang, Ming Zhang, Yong-Xiang Wei
PURPOSE: Obstructive sleep apnea (OSA) is associated with increased levels of systemic inflammatory markers, increased arterial stiffness, and endothelial dysfunction, which may lead to increased cardiovascular risk. We aimed to quantify the effects of continuous positive airway pressure (CPAP) on cardiovascular biomarkers and to establish predictors of response to CPAP. METHODS: We searched PubMed and the Cochrane Library from inception to May 31, 2017. Randomized controlled trials (RCTs) assessing the efficacy of CPAP on high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor- alpha (TNF-α), augmentation index (AIx), pulse wave velocity (PWV), and flow-mediated dilatation (FMD) in patients with OSA were selected by consensus...
April 22, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29682546/melatonin-for-atypical-antipsychotic-induced-metabolic-adverse-effects-a-meta-analysis-of-randomized-controlled-trials
#17
Ashwin Kamath, Zahoor Ahmad Rather
The objective of our study was to determine the effect of melatonin administration on atypical antipsychotic-induced metabolic adverse effects in patients with psychiatric disorders. A systematic search was performed in PUBMED, Cochrane Library, Scopus, Web of Science, and EBSCOhost electronic databases. Randomized controlled trials studying the effect of melatonin on antipsychotic-induced metabolic adverse effects were identified and subjected to meta-analysis. Four studies were included in the meta-analysis, including 57 patients on melatonin and 61 patients on placebo...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682210/age-at-menarche-and-risks-of-gestational-diabetes-mellitus-a-meta-analysis-of-prospective-studies
#18
Ya Xiao, Ruixue Chen, Minghao Chen, Anling Luo, Dayi Chen, Qiuer Liang, Yunfei Cai, Liguo Chen, Xiaoshan Zhao
Background: Accumulating evidence suggests that early menarche is associated with adult obesity, which in turn may increase the risk of insulin resistance and hyperglycemia. However, the relation of menarcheal age with gestational diabetes mellitus (GDM) remains inconsistent across studies. The objective of this meta-analysis was to evaluate the association between age at menarche and GDM risk. Materials and Methods: We searched Medline (PubMed), Embase, Web of Knowledge and the Cochrane library through the end of May 2017...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681929/efficacy-and-safety-of-argon-plasma-coagulation-for-hemorrhagic-chronic-radiation-proctopathy-a-systematic-review
#19
REVIEW
Yanan Peng, Haizhou Wang, Juerong Feng, Shilin Fang, Meng Zhang, Fan Wang, Ying Chang, Xianyan Shi, Qiu Zhao, Jing Liu
Hemorrhagic chronic radiation proctopathy (CRP) is a common complication after pelvic radiotherapy in patients with prostate or gynecological cancers. This systematic review was conducted to evaluate the efficacy and safety of argon plasma coagulation (APC) in treating hemorrhagic CRP. The databases of PubMed, Embase, and Cochrane Library were searched for related studies from inception to July 2017. Finally, 33 studies were identified with a total of 821 hemorrhagic CRP patients. After APC treatment, hemoglobin levels increased from 7...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29681911/fine-mapping-of-csvyl-conferring-virescent-leaf-through-the-regulation-of-chloroplast-development-in-cucumber
#20
Mengfei Song, Qingzhen Wei, Jing Wang, Wenyuan Fu, Xiaodong Qin, Xiumei Lu, Feng Cheng, Kang Yang, Lu Zhang, Xiaqing Yu, Ji Li, Jinfeng Chen, Qunfeng Lou
Leaf color mutants in higher plants are ideal materials for investigating the structure and function of photosynthetic system. In this study, we identified a cucumber vyl (virescent-yellow leaf) mutant in the mutant library, which exhibited reduced pigment contents and delayed chloroplast development process. F2 and BC1 populations were constructed from the cross between vyl mutant and cucumber inbred line 'Hazerd' to identify that the vyl trait is controlled by a simply recessive gene designated as CsVYL. The CsVYL gene was mapped to a 3...
2018: Frontiers in Plant Science
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