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https://www.readbyqxmd.com/read/28655176/a-systematic-review-and-meta-analysis-of-the-effectiveness-of-nudging-to-increase-fruit-and-vegetable-choice
#1
Valérie J V Broers, Céline De Breucker, Stephan Van den Broucke, Olivier Luminet
Background: Nudging refers to interventions that organize the choice architecture in order to alter people's behaviour in a predictable way without forbidding any options or significantly changing their economic incentives. As a strategy to encourage healthy behaviour, nudging can serve as a complement to health education. However, the empirical evidence regarding the effectiveness of nudging as a way to influence food choice remains contradictory. To address this issue, a systematic review and meta-analysis was conducted to test the effects of nudging to encourage people to select more fruit and vegetables...
June 25, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28655027/zolpidem-for-the-treatment-of-neurologic-disorders-a-systematic-review
#2
Martin N Bomalaski, Edward S Claflin, Whitney Townsend, Mark D Peterson
Importance: Given its selective action on the ω1 subtype of the γ-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. Objective: To synthesize studies that used zolpidem to treat neurologic disorders. Evidence Review: Eligibility criteria included any published English-language article that examined the use of zolpidem for noninsomnia neurologic disorders in humans for all dates up to March 20, 2015...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28654986/association-between-initial-use-of-e-cigarettes-and-subsequent-cigarette-smoking-among-adolescents-and-young-adults-a-systematic-review-and-meta-analysis
#3
Samir Soneji, Jessica L Barrington-Trimis, Thomas A Wills, Adam M Leventhal, Jennifer B Unger, Laura A Gibson, JaeWon Yang, Brian A Primack, Judy A Andrews, Richard A Miech, Tory R Spindle, Danielle M Dick, Thomas Eissenberg, Robert C Hornik, Rui Dang, James D Sargent
Importance: The public health implications of e-cigarettes depend, in part, on whether e-cigarette use affects the risk of cigarette smoking. Objective: To perform a systematic review and meta-analysis of longitudinal studies that assessed initial use of e-cigarettes and subsequent cigarette smoking. Data Sources: PubMed, EMBASE, Cochrane Library, Web of Science, the 2016 Society for Research on Nicotine and Tobacco 22nd Annual Meeting abstracts, the 2016 Society of Behavioral Medicine 37th Annual Meeting & Scientific Sessions abstracts, and the 2016 National Institutes of Health Tobacco Regulatory Science Program Conference were searched between February 7 and February 17, 2017...
June 26, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28654900/specific-microrna-library-of-ifn-%C3%AF-on-bovine-endometrial-epithelial-cells
#4
Haichong Wu, Tao Zhang, Xiaofei Ma, Kangfeng Jiang, Gan Zhao, Changwei Qiu, Ganzhen Deng
IFN-τ is specifically secreted by the conceptus in ruminants during early pregnancy, and it plays a vital role in the immunological function of pregnancy. However, its mechanism involving microRNA (miRNA) is still not well understood. Deep sequencing was used to explore the specific miRNA library of IFN-τ on bovine endometrial epithelial cells (bEECs). The results showed that 574 known bovine miRNAs and 109 novel miRNAs were identified. We found 74 differentially expressed miRNAs, including 30 commonly expressed miRNAs in the experiment...
June 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654884/specific-and-selective-probes-for-staphylococcus-aureus-from-phage-displayed-random-peptide-libraries
#5
Laura M De Plano, Santina Carnazza, Grazia M L Messina, Maria Giovanna Rizzo, Giovanni Marletta, Salvatore P P Guglielmino
Staphylococcus aureus is a major human pathogen causing health care-associated and community-associated infections. Early diagnosis is essential to prevent disease progression and to reduce complications that can be serious. In this study, we selected, from a 9-mer phage peptide library, a phage clone displaying peptide capable of specific binding to S. aureus cell surface, namely St.au9IVS5 (sequence peptide RVRSAPSSS).The ability of the isolated phage clone to interact specifically with S. aureus and the efficacy of its bacteria-binding properties were established by using enzyme linked immune-sorbent assay (ELISA)...
June 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28654733/target-directed-dynamic-combinatorial-chemistry-a-study-on-potentials-and-pitfalls-as-exemplified-on-a-bacterial-target
#6
Beat Ernst, Priska Frei, Lijuan Pang, Marleen Silbermann, Deniz Eris, Tobias Mühlethaler, Oliver Schwardt
Target-directed dynamic combinatorial chemistry (DCC) is an emerging technique for the efficient identification of inhibitors of pharmacologically relevant targets. In this contribution, we present an application for a bacterial target, the lectin FimH, a crucial virulence factor of uropathogenic E. coli being the main cause of urinary tract infections. A small dynamic library of acylhydrazones was formed from aldehydes and hydrazides and equilibrated at neutral pH in presence of aniline as nucleophilic catalyst...
June 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28654662/generation-of-a-rabbit-single-chain-fragment-variable-scfv-antibody-for-specific-detection-of-bradyrhizobium-sp-doa9-in-both-free-living-and-bacteroid-forms
#7
Nguyen Xuan Vu, Natcha Pruksametanan, Witsanu Srila, Watcharin Yuttavanichakul, Kamonluck Teamtisong, Neung Teaumroong, Nantakorn Boonkerd, Panlada Tittabutr, Montarop Yamabhai
A simple and reliable method for the detection of specific nitrogen-fixing bacteria in both free-living and bacteroid forms is essential for the development and application of biofertilizer. Traditionally, a polyclonal antibody generated from an immunized rabbit was used for detection. However, the disadvantages of using a polyclonal antibody include limited supply and cross-reactivity to related bacterial strains. This is the first report on the application of phage display technology for the generation of a rabbit recombinant monoclonal antibody for specific detection and monitoring of nitrogen-fixing bacteria in both free-living form and in plant nodules...
2017: PloS One
https://www.readbyqxmd.com/read/28654627/effect-of-programmed-exercise-on-insulin-sensitivity-in-postmenopausal-women-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
Juan Bueno-Notivol, Julia Calvo-Latorre, Vanesa Alonso-Ventura, Vinay Pasupuleti, Adrian V Hernandez, Faustino R Pérez-López
OBJECTIVE: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effect of programmed exercise for at least 12 weeks, in postmenopausal women on insulin sensitivity-related outcomes (ISROs), including fasting insulin, C-peptide, insulin growth factor (IGF-1) and IGF-binding protein (IGFBP-3), Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), and anthropometric variables. METHODS: Searches were conducted in PubMed-Medline, Embase, Scopus, Web of Science, and Cochrane Library from inception through May 3, 2016, for studies published in all languages...
June 26, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28654308/does-parenteral-nutrition-increase-the-risk-of-catheter-related-bloodstream-infection-a-systematic-literature-review
#9
Nicole Clare Gavin, Elise Button, Samantha Keogh, David McMillan, Claire Rickard
BACKGROUND: Central venous access devices (CVADs) are used for parenteral nutrition (PN) delivery. We systematically reviewed research-based publications that reported comparative rates of catheter-related bloodstream infection (CRBSI) in patients with CVADs who received PN vs those who did not receive PN therapy. MATERIALS AND METHODS: The literature search included the Cochrane Library, MEDLINE, CINAHL, and PubMed up to July 14, 2015, to identity studies that compared patients with a CVAD who did and did not have PN therapy...
June 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28654179/exploiting-the-evolutionary-relationship-between-malarial-parasites-and-plants-to-develop-new-herbicides
#10
Maxime G Corral, Julie Leroux, Stefan Tresch, Trevor Newton, Keith A Stubbs, Joshua S Mylne
Herbicide resistance is driving a need to develop new herbicides. The evolutionary relationship between apicomplexan parasites, such as those causing malaria, and plants is close enough that many antimalarial drugs are herbicidal and so represent novel scaffolds for herbicide development. Using a compound library from the Malaria Vaccine Venture initiative, the model plant Arabidopsis thaliana and a physicochemical database of known herbicides, a compound was discovered that showed post-emergence herbicidal activity equal to commercial herbicides...
June 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28654159/acute-alcohol-exposure-and-risk-of-mortality-of-patients-with-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#11
Qiuping Ding, Zhuo Wang, Meifen Shen, Zhongzhou Su, Liang Shen
After traumatic brain injury (TBI), patients usually live with significant disability and socioeconomic burdens. Acute exposure to alcohol is considered a major risk factor for TBI. Numerous studies have examined whether alcohol exposure is related to the risk of mortality in patients with TBI, yet the results remain inconsistent. We performed a meta-analysis to assess whether acute alcohol exposure affects the mortality rate of TBI patients. We searched PubMed, Embase and the Cochrane Library up to November 2015 for relevant studies...
June 27, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28654140/epidermal-growth-factor-receptor-egfr-inhibitors-for-metastatic-colorectal-cancer
#12
REVIEW
David Lok Hang Chan, Eva Segelov, Rachel Sh Wong, Annabel Smith, Rebecca A Herbertson, Bob T Li, Niall Tebbutt, Timothy Price, Nick Pavlakis
BACKGROUND: Epidermal growth factor receptor (EGFR) inhibitors prevent cell growth and have shown benefit in the treatment of metastatic colorectal cancer, whether used as single agents or in combination with chemotherapy. Clear benefit has been shown in trials of EGFR monoclonal antibodies (EGFR MAb) but not EGFR tyrosine kinase inhibitors (EGFR TKI). However, there is ongoing debate as to which patient populations gain maximum benefit from EGFR inhibition and where they should be used in the metastatic colorectal cancer treatment paradigm to maximise efficacy and minimise toxicity...
June 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28654111/direct-access-to-isoxazolino-and-isoxazolo-benzazepines-from-2-hydroxyimino-methyl-benzoic-acid-via-a-post-ugi-heteroannulation
#13
Saeed Balalaie, Mohammad Shamakli, Ali Nikbakht, Nahid S Alavijeh, Frank Rominger, Shahnaz Rostamizadeh, Hamid Reza Bijanzadeh
A diversity-oriented access to isoxazolino and isoxazolo benzazepines is elaborated via a post-Ugi heteroannulation involving intramolecular 1,3-dipolar cycloaddition reaction of nitrile oxides with alkenes and alkynes. This sequence offers an interesting multicomponent entry to a library of isoxazolino and isoxazolo benzazepines under mild reaction conditions in good to excellent yields.
June 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28654083/targeted-metagenomic-sequencing-data-of-human-gut-microbiota-associated-with-blastocystis-colonization
#14
Léa Siegwald, Christophe Audebert, Gaël Even, Eric Viscogliosi, Ségolène Caboche, Magali Chabé
In the past decade, metagenomics studies have become widespread due to the arrival of second-generation sequencing platforms characterized by low costs, high throughput and short read lengths. Today, although benchtop sequencers are considered to be accurate platforms to deliver data for targeted metagenomics studies, the limiting factor has become the analysis of these data. In a previous paper, we performed an Ion Torrent PGM 16S rDNA gene sequencing of faecal DNAs from 48 Blastocystis-colonized patients and 48 Blastocystis-negative subjects, in order to decipher the impact of this widespread protist on gut microbiota composition and diversity...
June 27, 2017: Scientific Data
https://www.readbyqxmd.com/read/28654052/flow-sorting-and-exome-sequencing-of-the-reed-sternberg-cells-of-classical-hodgkin-lymphoma
#15
Jonathan B Reichel, Jason McCormick, Jonathan R Fromm, Olivier Elemento, Ethel Cesarman, Mikhail Roshal
The Hodgkin Reed-Sternberg cells of classical Hodgkin lymphoma are sparsely distributed within a background of inflammatory lymphocytes and typically comprise less than 1% of the tumor mass. Material derived from bulk tumor contains tumor content at a concentration insufficient for characterization. Therefore, fluorescence activated cell sorting using eight antibodies, as well as side- and forward-scatter, is described here as a method of rapidly separating and concentrating with high purity thousands of HRS cells from the tumor for subsequent study...
June 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654001/profiling-the-extended-cleavage-specificity-of-the-house-dust-mite-protease-allergens-der-p-1-der-p-3-and-der-p-6-for-the-prediction-of-new-cell-surface-protein-substrates
#16
Alain Jacquet, Vincenzo Campisi, Martyna Szpakowska, Marie-Eve Dumez, Moreno Galleni, Andy Chevigné
House dust mite (HDM) protease allergens, through cleavages of critical surface proteins, drastically influence the initiation of the Th2 type immune responses. However, few human protein substrates for HDM proteases have been identified so far, mainly by applying time-consuming target-specific individual studies. Therefore, the identification of substrate repertoires for HDM proteases would represent an unprecedented key step toward a better understanding of the mechanism of HDM allergic response. In this study, phage display screenings using totally or partially randomized nonameric peptide substrate libraries were performed to characterize the extended substrate specificities (P₅-P₄') of the HDM proteases Der p 1, Der p 3 and Der p 6...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28653911/bacterial-communities-in-soil-samples-from-the-mingyong-glacier-of-southwestern-china
#17
Haoyu Li, Muhammad Kamran Taj, Xiuling Ji, Qi Zhang, Liangbing Lin, Zhimei Zhou, Yunlin Wei
The present study was an effort to determine the bacterial diversity of soils in Mingyong Glacier located at the Meili Snow Mountains of southwestern China. Mingyong Glacier has different climatic zones within a very narrow area, and bacterial community diversity in this low temperature area remains largely unknown. In this study, soil samples were collected from four different climatic zones: M11A (dry warm valley), M14 (forest), M15 (grass land), and M16 (glacier zones). Phylogenetic analysis based on 16S rRNA gene V6 hypervariable region showed high bacterial abundance in the glacier...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653747/pharmacological-treatment-of-orofacial-pain-health-technology-assessment-including-a-systematic-review-with-network-meta-analysis
#18
REVIEW
B Häggman-Henrikson, P Alstergren, T Davidson, Ed Högestätt, P Östlund, S Tranaeus, S Vitols, T List
This health technology assessment evaluated the efficacy of pharmacological treatment in patients with orofacial pain. Randomised controlled trials were included if they reported pharmacological treatment in patients ≥18 years with chronic (≥3 months) orofacial pain. Patients were divided into subgroups: TMD-muscle [Temporomandibular disorders (TMD) mainly associated with myalgia]; TMD-joint (TMD mainly associated with temporomandibular joint pain); and Burning mouth syndrome (BMS). The primary outcome was pain intensity reduction after pharmacological treatment...
June 27, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28653538/cationic-polypeptoids-with-optimized-molecular-characteristics-toward-efficient-non-viral-gene-delivery
#19
Lipeng Zhu, Jessica M Simpson, Xin Xu, Hua He, Donghui Zhang, Lichen Yin
The rational design of gene vectors relies on the understanding of their structure-property relationship. Polypeptoids, structural isomers of natural polypeptides, hold great potentials as gene delivery vectors due to their facial preparation, structural tunability, and most importantly, desired proteolytic stability. We herein designed a library of polypeptoids with different cationic side-chain terminal groups, degrees of polymerization (DP), side-chain lengths, and incorporated aliphatic side chains, attempting to unravel the structure-property relationship toward maximized gene delivery efficiency while minimized cytotoxicity...
June 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28653482/stimvision-software-examples-and-applications-in-subcallosal-cingulate-deep-brain-stimulation-for-depression
#20
Angela M Noecker, Ki Sueng Choi, Patricio Riva-Posse, Robert E Gross, Helen S Mayberg, Cameron C McIntyre
OBJECTIVE: Create a software tool to facilitate tractography-based deep brain stimulation (DBS) electrode targeting within the patient-specific stereotactic coordinate system used in the operating room. APPROACH: StimVision was developed with Visualization Toolkit libraries and integrates four major components: 1) medical image visualization, 2) tractography visualization, 3) DBS electrode positioning, and 4) DBS activation volume calculation with tractography intersection...
June 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
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