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https://www.readbyqxmd.com/read/27936516/neuroprotection-of-hypoxic-postconditioning-against-global-cerebral-ischemia-through-influencing-posttranslational-regulations-of-heat-shock-protein-27-in-adult-rats
#1
Lixuan Zhan, Liu Liu, Kongping Li, Baoxing Wu, Dandan Liu, Donghai Liang, Haixia Wen, Yanmei Wang, Weiwen Sun, Weiping Liao, En Xu
We previously reported that hypoxic postconditioning (HPC) ameliorated hippocampal neuronal death induced by transient global cerebral ischemia (tGCI) in adult rats. However, the mechanism of HPC-induced neuroprotection is still elusive. Notably, heat shock protein 27 (Hsp27) has recently emerged as a potent neuroprotectant in cerebral ischemia. Although its robust protective effect on stroke has been recognized, the mechanism of Hsp27-mediated neuroprotection is largely unknown. Here, we investigated the potential molecular mechanism by which HPC modulates the posttranslational regulations of Hsp27 after tGCI...
December 9, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27936511/znf208-polymorphisms-associate-with-ischemic-stroke-in-southern-chinese-han-population
#2
Jianzhong Yu, Feng Zhou, Dong Luo, Nianzhen Wang, Chong Zhang, Tianbo Jin, Xiongfei Liang, Dan Yu
BACKGROUND: Ischemic stroke is one of the most common diseases with a high burden of neurological deficits, disability and death. Zinc finger protein 208 (ZNF208) was found to be involved in coronary heart disease, but little information was about its association with ischemic stroke. We performed this case-control study to elucidate the association between single-nucleotide polymorphisms (SNPs) within ZNF208 and risk of ischemic stroke in southern Chinese Han population. METHODS: A total of 799 subjects (400 cases and 399 health controls) were enrolled in this study...
December 9, 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27936262/-a-mental-health-hygiene-experiment-the-case-of-les-pinceaux-d-or
#3
Hubert Wallot
Many research, notably that of Gene Cohen (2007), have shown positive impact of artistic activities for seniors. In 2006 in Quebec City, three professional painters have created a none lucrative organization called Les Pinceaux d'Or (The Golden Brushes). Its mission is to create a positive experience of painting learning in elderly needing persons. The organization operates in long-term health-care facilities or in low-income housings and day centers. It offers free painting courses to elderly persons referred by local community health centers or community organizations as seniors with psychosocial needs...
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27936187/stroke-as-the-first-manifestation-of-atrial-fibrillation
#4
Jussi Jaakkola, Pirjo Mustonen, Tuomas Kiviniemi, Juha E K Hartikainen, Antti Palomäki, Päivi Hartikainen, Ilpo Nuotio, Antti Ylitalo, K E Juhani Airaksinen
Atrial fibrillation may remain undiagnosed until an ischemic stroke occurs. In this retrospective cohort study we assessed the prevalence of ischemic stroke or transient ischemic attack as the first manifestation of atrial fibrillation in 3,623 patients treated for their first ever stroke or transient ischemic attack during 2003-2012. Two groups were formed: patients with a history of atrial fibrillation and patients with new atrial fibrillation diagnosed during hospitalization for stroke or transient ischemic attack...
2016: PloS One
https://www.readbyqxmd.com/read/27936074/association-between-metabolic-syndrome-and-cognitive-impairment-after-acute-ischemic-stroke-a-cross-sectional-study-in-a-chinese-population
#5
Pan Li, Wei Quan, Da Lu, Yan Wang, Hui-Hong Zhang, Shuai Liu, Rong-Cai Jiang, Yu-Ying Zhou
BACKGROUND AND OBJECTIVES: Metabolic syndrome (MetS), a risk factor for many vascular conditions, is associated with vascular cognitive disorders. The objective of the present study was to explore the associations of MetS and its individual components with the risks of cognitive impairment and neurological dysfunction in patients after acute stroke. METHODS: This cross-sectional study enrolled 840 patients ranging in age from 53 to 89 years from the Tianjin area of North China...
2016: PloS One
https://www.readbyqxmd.com/read/27936005/rare-variants-in-nod1-associated-with-carotid-bifurcation-intima-media-thickness-in-dominican-republic-families
#6
Nicole D Dueker, Ashley Beecham, Liyong Wang, Susan H Blanton, Shengru Guo, Tatjana Rundek, Ralph L Sacco
Cardiovascular disorders including ischemic stroke (IS) and myocardial infarction (MI) are heritable; however, few replicated loci have been identified. One strategy to identify loci influencing these complex disorders is to study subclinical phenotypes, such as carotid bifurcation intima-media thickness (bIMT). We have previously shown bIMT to be heritable and found evidence for linkage and association with common variants on chromosome 7p for bIMT. In this study, we aimed to characterize contributions of rare variants (RVs) in 7p to bIMT...
2016: PloS One
https://www.readbyqxmd.com/read/27935987/patient-reported-treatment-satisfaction-with-rivaroxaban-for-stroke-prevention-in-atrial-fibrillation-a-french-observational-study-the-safari-study
#7
Olivier Hanon, Edouard Chaussade, Pierre Gueranger, Elise Gruson, Sabrina Bonan, Alain Gay
BACKGROUND: For antithrombotic treatments, Patient Reported Outcomes (PRO) and patient satisfaction with treatment are essential data for physicians because of the strong relationship between patient satisfaction and adherence to treatment. The impact of rivaroxaban on patient satisfaction and quality of life was not sufficiently documented in phase III studies. There is a need for further data in this field especially in real life conditions. METHODS: The SAFARI study is composed of patients with non-valvular atrial fibrillation (AF), previously treated with vitamin K antagonist (VKA) and switched to rivaroxaban...
2016: PloS One
https://www.readbyqxmd.com/read/27935977/the-effects-of-a-community-based-sodium-reduction-program-in-rural-china-a-cluster-randomized-trial
#8
Nicole Li, Lijing L Yan, Wenyi Niu, Chen Yao, Xiangxian Feng, Jianxin Zhang, Jingpu Shi, Yuhong Zhang, Ruijuan Zhang, Zhixin Hao, Hongling Chu, Jing Zhang, Xian Li, Jianhong Pan, Zhifang Li, Jixin Sun, Bo Zhou, Yi Zhao, Yan Yu, Michael Engelgau, Darwin Labarthe, Jixiang Ma, Stephen MacMahon, Paul Elliott, Yangfeng Wu, Bruce Neal
BACKGROUND: Average sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed. OBJECTIVE: We sought to determine the effects of a community-based sodium reduction program on salt consumption in rural northern China. DESIGN: This study was a cluster-randomized trial done over 18 months in 120 townships (one village from each township) from five provinces...
2016: PloS One
https://www.readbyqxmd.com/read/27935930/acute-ischemic-stroke-and-acute-on-chronic-kidney-disease
#9
R A Aftab, A H Khan, H A AbdulRazzaq, A S Adnan
Ischemic stroke is due to either local thrombus formation or emboli that occlude a cerebral artery, together with chronic kidney disease represent major mortality and morbidity.Here we present a case of 53 years old Malay man, admitted to a hospital in Malaysia complaining of sudden on set of weakness on right sided upper and lower limb associated with slurred speech. Patient was also suffering from uncontrolled hypertension, hyperlipidemia, chronic kidney disease stage 4, and diabetes mellitus (uncontrolled)...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935890/-surgical-prevention-of-ischaemic-strokes-by-means-of-an-extraintracranial-microanastomosis-eicma-in-the-carotid-basin
#10
V V Krylov, V A Luk'yanchikov, A S Tokarev, O Yu Nakhabin, N A Polunina, I V Sen'ko, V A Dalibaldyan, E V Grigor'eva, N E Kudryashova, G K Guseinova, E V Udodov, T A Fedulova
BACKGROUND: Not less than 50% of all ischaemic strokes appear to occur resulting from pathology of extracranial arteries. Occlusions and stenoses are more commonly encountered in carotid arteries, with the incidence of occlusion of the internal carotid artery (ICA) ranging from 5 to 10% within the structure of all lesions of brachiocephalic arteries (BCA). AIM: The study was aimed at assessing the results of a surgical procedure of extra-intracranial microanastomosis (EICMA) performed in patients presenting with occlusive and stenotic lesions of BCA at the Neurosurgical Department...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935736/pioglitazone-and-risk-for-bone-fracture-safety-data-from-a-randomized-clinical-trial
#11
Catherine M Viscoli, Silvio E Inzucchi, Lawrence H Young, Karl L Insogna, Robin Conwit, Karen L Furie, Mark Gorman, Michael A Kelly, Anne M Lovejoy, Walter N Kernan
CONTEXT: Pioglitazone reduces cardiovascular risk in non-diabetic patients after an ischemic stroke or transient ischemic attack (TIA) but is associated with increased risk for bone fracture. OBJECTIVE: To characterize fractures associated with pioglitazone by location, mechanism, severity, timing, and sex. DESIGN, SETTING AND PATIENTS: Patients were 3876 non-diabetic participants in the Insulin Resistance Intervention after Stroke trial randomized to pioglitazone or placebo after an ischemic stroke or TIA and followed for a median of 4...
December 9, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27935582/global-ischemia-induces-lysosomal-mediated-degradation-of-mtor-and-activation-of-autophagy-in-hippocampal-neurons-destined-to-die
#12
Jee-Yeon Hwang, Michael Gertner, Fabrizio Pontarelli, Brenda Court-Vazquez, Michael Vander Laan Bennett, Dimitry Ofengeim, Ruth Suzanne Zukin
The mammalian target of rapamycin (mTOR) is a key regulator of cell growth, autophagy, translation, and survival. Dysregulation of mTOR signaling is associated with cancer, diabetes, and autism. However, a role for mTOR signaling in neuronal death is not well delineated. Here we show that global ischemia triggers a transient increase in mTOR phosphorylation at S2448, whereas decreasing p-mTOR and functional activity in selectively vulnerable hippocampal CA1 neurons. The decrease in mTOR coincides with an increase in biochemical markers of autophagy, pS317-ULK-1, pS14-Beclin-1, and LC3-II, a decrease in the cargo adaptor p62, and an increase in autophagic flux, a functional readout of autophagy...
December 9, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27935558/evaluation-of-body-temperature-in%C3%A2-individuals-with-stroke
#13
Fábio Marcon Alfieri, Ayrton Roberto Massaro, Thais Raquel Filippo, Leslie Andrews Portes, Linamara Rizzo Battistella
BACKGROUND: A stroke can cause alterations in thermal sensitivity. OBJECTIVE: to verify the conditions of body temperature in hemiplegic patients after stroke as compared to healthy individuals, as well as establish relations between thermal sensitivity and gender, age, Body Mass Index (BMI), plegic side, time after stroke, reports of thermal alterations and the motricity of patients with stroke sequelae. METHODS: This cross-sectional study included 100 patients (55...
December 8, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27935557/wearable-tubing-assistive-walking-device-immediately-enhances-gait-parameters-in-subjects-with-stroke-a-randomized-controlled-study
#14
Seung-Mi Lee, Heon-Seock Cynn, Chung-Hwi Yi, Tae-Lim Yoon, Ji-Hyun Lee
BACKGROUND: Stroke patients develop compensatory movements due to limitations of ankle dorsiflexion and knee flexion. To solve the limitations, there are many adjustable walking assistive devices such as robotic devices, ankle-foot orthoses, and functional electric stimulation in rehabilitation session. However, these assistive devices have some disadvantages, including expense and discomforts. Therefore, the development of a new assistive device for stroke patients is needed to assist ankle dorsiflexion and knee flexion...
December 8, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27935472/trunk-compensation-during-bimanual-reaching-at-different-heights-by-healthy-and-hemiparetic-adults
#15
Bulmaro A Valdés, Stephanie M N Glegg, H F Machiel Van der Loos
The authors explored how trunk compensation and hand symmetry in stroke survivors and healthy controls were affected by the distance and height of virtual targets during a bimanual reaching task. Participants were asked to reach to 4 different virtual targets set at: 90% of their arm length at shoulder, xiphoid process, and knee height, and 50% of their arm length at xiphoid process height. For the stroke group, for all targets, the hands' movements were more asymmetrical than those of the healthy group, with more asymmetry observed in the direction of gravity, and trunk forward displacement values were larger and more variable...
December 9, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27935469/preoperative-transdural-collateral-vessels-in-moyamoya-as-radiographic-biomarkers-of-disease
#16
Armide Storey, R Michael Scott, Richard Robertson, Edward Smith
OBJECTIVE The prevalence of angiographically evident preoperative transdural collateral vessels in moyamoya is not well documented. The authors hypothesized that transdural collaterals could be used as radiographic biomarkers of disease, and that their presence is associated with more advanced moyamoya arteriopathy at diagnosis, which is a harbinger of more frequent operative complications and a predictor of better long-term angiographic results following surgery. METHODS The study consists of a single-institution case series of patients with moyamoya who underwent pial synangiosis between 2005 and 2013...
December 9, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27935151/patient-related-characteristics-associated-with-non-persistence-with-statin-therapy-in-elderly-patients-following-an-ischemic-stroke
#17
Martin Wawruch, Dusan Zatko, Gejza Wimmer, Jan Luha, Vasil Hricak, Jan Murin, Peter Kukumberg, Tomas Tesar, Adam Hloska, Rashmi Shah
PURPOSE: This study was aimed at evaluating the extent of non-persistence with statin therapy in elderly patients after an ischemic stroke and identifying patient-related characteristics that are risk factors for non-persistence. METHODS: The evaluable study cohort (n = 2748) was derived from the database of the largest health insurance provider in the Slovak Republic. Patients aged ≥65 years who were initiated on statin therapy following the diagnosis of an ischemic stroke during one full year (1 January 2010 to 31 December 2010) constituted this cohort...
December 9, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27935138/characteristics-of-accredited-transcranial-doppler-ultrasound-laboratories-in-the-united-states
#18
Mary Beth Farrell, John Y Choi, Endrit Ziu, Kevin M Cockroft
PURPOSE: The aim of this study was to describe in detail the characteristics and accreditation compliance of laboratories in the United States applying for Intersocietal Accreditation Commission (IAC) transcranial Doppler (TCD) accreditation. METHODS: This was a retrospective study of all applicant laboratories from 2012 to 2015. We used the IAC database to extract laboratory characteristics and guideline compliance metrics. RESULTS: Evaluation of 97 laboratories demonstrated that 67% were hospital-based and located in the South (43...
December 9, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27934941/oral-cnm-positive-streptococcus-mutans-expressing-collagen-binding-activity-is-a-risk-factor-for-cerebral-microbleeds-and-cognitive-impairment
#19
Isao Watanabe, Nagato Kuriyama, Fumitaro Miyatani, Ryota Nomura, Shuhei Naka, Kazuhiko Nakano, Masafumi Ihara, Komei Iwai, Daisuke Matsui, Etsuko Ozaki, Teruhide Koyama, Masaru Nishigaki, Toshiro Yamamoto, Aiko Tamura, Toshiki Mizuno, Kentaro Akazawa, Akihiro Takada, Kazuo Takeda, Kei Yamada, Masanori Nakagawa, Tokutaro Tanaka, Narisato Kanamura, Robert P Friedland, Yoshiyuki Watanabe
Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934548/arhgef10-gene-polymorphism-is-closely-associated-with-the-risk-of-ischemic-stroke-in-northern-han-chinese-population
#20
Hong Li, Shasha Yu, Rui Wang, Zhaoqing Sun, Xinghu Zhou, Liqiang Zheng, Zhihua Yin, Xingang Zhang, Yingxian Sun
Stroke is a common disease with high mortality and morbidity. It is of high importance to identify biomarkers of stroke. Rho guanine nucleotide-exchange factor(GEF) 10 (ARHGEF10) gene polymorphism has been found to be associated with various human diseases, but its correlation with stroke remains unknown. This study aims to evaluate the potential association of the single nucleotide polymorphisms (SNPs) of ARHGEF10 with ischemic stroke (IS) in northern Han Chinese population. Three SNPs of ARHGEF10 gene were analyzed in 385 IS patients and 362 hypertension control patients using the ligase detection reaction (LDR) method...
December 9, 2016: Neurological Research
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