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https://www.readbyqxmd.com/read/29241238/hyperbaric-oxygen-associated-seizure-leading-to-stroke
#1
Jordan M Warchol, Jeffrey S Cooper, Thomas S Diesing
Oxygen toxicity seizures are a well-known complication of hyperbaric oxygen treatment (HBOT). Until now, there have not been any reported cases of an acute ischaemic event (stroke) as the result of a HBOT-associated oxygen toxicity seizure. We report an event in which a seizure and stroke occurred together and consider that the stroke may have been caused by seizure-induced demand ischaemia. This challenges the generally held view that oxygen toxicity seizures in the clinical hyperbaric setting are benign. A discussion of the literature on the subject of seizure-induced brain injury is included...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29241198/fam3a-protects-against-glutamate-induced-toxicity-by-preserving-calcium-homeostasis-in-differentiated-pc12-cells
#2
Qing Song, Wen-Li Gou, Yu-Liang Zou
BACKGROUND/AIMS: Stroke is the leading cause of adult disability, and glutamate-induced dysregulation of intracellular Ca2+ homeostasis is a key mechanism. FAM3A is the first member of the family with sequence similarity 3 (FAM3) gene family, and its biological function remains largely unknown. We have recently reported that FAM3A exerts protective effects against oxidative stress and mitochondrial dysfunction in HT22 cells. METHODS: Here, we investigated the protective effects of FAM3A using a glutamate-induced neuronal injury model in nerve growth factor (NGF)-differentiated PC12 cells...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241193/comparative-analysis-on-low-and-standard-dose-regimes-of-alteplase-thrombolytic-therapy-for-acute-ischemic-stroke-efficacy-and-safety
#3
Guangjian Zhao, Tingfen Huang, Mei Zheng, Yansen Cui, Yunyong Liu, Zhongrong Cheng, Ziran Wang
OBJECTIVE: This study analyzed the efficacy and safety of low-dose and standard-dose alteplase intravenous thrombolytic therapy for acute ischemic stroke (AIS). METHODS: Patients with AIS who underwent intravenous alteplase thrombolysis from July 2012 to December 2016 were retrospectively analyzed and correspondingly divided into low-dose (0.6-0.89 mg/kg) group and standard-dose group (0.9 mg/kg) according to alteplase dosage. The clinical outcome was evaluated by modified Rankin Scale (mRS) at 90 days after onset...
December 14, 2017: European Neurology
https://www.readbyqxmd.com/read/29241068/long-term-projections-of-temperature-related-mortality-risks-for-ischemic-stroke-hemorrhagic-stroke-and-acute-ischemic-heart-disease-under-changing-climate-in-beijing-china
#4
Tiantian Li, Radley M Horton, Daniel A Bader, Fangchao Liu, Qinghua Sun, Patrick L Kinney
BACKGROUND: Changing climates have been causing variations in the number of global ischemic heart disease and stroke incidences, and will continue to affect disease occurrence in the future. OBJECTIVES: To project temperature-related mortality for acute ischemic heart disease, and ischemic and hemorrhagic stroke with concomitant climate warming. METHODS: We estimated the exposure-response relationship between daily cause-specific mortality and daily mean temperature in Beijing...
December 11, 2017: Environment International
https://www.readbyqxmd.com/read/29240976/clopidogrel-plus-aspirin-versus-aspirin-alone-for-preventing-cardiovascular-events
#5
REVIEW
Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo Donadini
BACKGROUND: Aspirin is the prophylactic antiplatelet drug of choice for people with cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional benefit for people at high risk and people with established cardiovascular disease. This is an update to a previously published review from 2011. OBJECTIVES: To review the benefit and harm of adding clopidogrel to aspirin therapy for preventing cardiovascular events in people who have coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease, or were at high risk of atherothrombotic disease, but did not have a coronary stent...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29240808/altered-cerebral-hemodyamics-and-cortical-thinning-in-asymptomatic-carotid-artery-stenosis
#6
Randolph S Marshall, Iris Asllani, Marykay A Pavol, Ying-Kuen Cheung, Ronald M Lazar
Cortical thinning is a potentially important biomarker, but the pathophysiology in cerebrovascular disease is unknown. We investigated the association between regional cortical blood flow and regional cortical thickness in patients with asymptomatic unilateral high-grade internal carotid artery disease without stroke. Twenty-nine patients underwent high resolution anatomical and single-delay, pseudocontinuous arterial spin labeling magnetic resonance imaging with partial volume correction to assess gray matter baseline flow...
2017: PloS One
https://www.readbyqxmd.com/read/29240784/effects-of-calcium-channel-blockers-comparing-to-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-in-patients-with-hypertension-and-chronic-kidney-disease-stage-3-to-5-and-dialysis-a-systematic-review-and-meta-analysis
#7
Yen-Chung Lin, Jheng-Wei Lin, Mai-Szu Wu, Kuan-Chou Chen, Chiung-Chi Peng, Yi-No Kang
BACKGROUND: Calcium channel blocker (CCB) or two renin angiotensin aldosterone system blockades (RAAS), angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are major potent and prevalently used as initial antihypertensive agents for mild to moderate hypertension, but no uniform agreement as to which antihypertensive drugs should be given for initial therapy, especially among chronic kidney disease (CKD) patients. DESIGN: A systematic review and meta-analysis comparing CCBs and the two RAAS blockades for hypertensive patients with CKD stage 3 to 5D...
2017: PloS One
https://www.readbyqxmd.com/read/29240651/acute-impact-of-different-exercise-modalities-on-arterial-and-platelet-function
#8
Andrew Haynes, Matthew D Linden, Elisa Robey, Gerald F Watts, P Hugh R Barrett, Louise H Naylor, Daniel J Green
PURPOSE: Acute coronary syndromes and ischemic stroke are associated with arterial events involving platelets, the endothelium and atherosclerosis. Whilst regular physical activity is associated with lower risk of cardiovascular events and mortality, risk is transiently increased during and immediately following participation in an acute bout of exercise. No previous study has investigated the acute impact of exercise on platelet activation and arterial function in the same participants; it is also unknown if responses are dependent on exercise modality...
December 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29240533/investigation-of-perceptual-motor-behavior-across-the-expert-athlete-to-disabled-patient-skill-continuum-can-advance-theory-and-practical-application
#9
Sean Müller, Ann-Maree Vallence, Carolee Winstein
A framework is presented of how theoretical predictions can be tested across the expert athlete to disabled patient skill continuum. Common-coding theory is used as the exemplar to discuss sensory and motor system contributions to perceptual-motor behavior. Behavioral and neural studies investigating expert athletes and patients recovering from cerebral stroke are reviewed. They provide evidence of bi-directional contributions of visual and motor systems to perceptual-motor behavior. Majority of this research is focused on perceptual-motor performance or learning, with less on transfer...
December 14, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29240320/time-has-not-passed-for-the-tilt-table-test
#10
Jani Pirinen, Markku Walamies
INTRODUCTION: The tilt table test is used for determining the loss of consciousness, and in the case of reflex syncope, for gaining insight into the circulatory mechanism. In 2015, all tilt tests within the Hospital District of Helsinki and Uusimaa (HUS) were performed in the clinical physiology unit of the HUS Medical Imaging Center at Peijas Hospital. METHODS: The patients' medical history, circulation monitor printouts, and medical reports were recorded from all tilt tests carried out during 2015...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29240071/-remote-results-of-open-surgical-and-endovascular-treatment-of-internal-carotid-artery-stenoses
#11
REVIEW
R A Vinogradov, V S Pykhteev, K A Lashevich
The article is a review containing a comparative analysis of the remote results in patients presenting with carotid artery atherosclerosis and treated by means of either stenting or carotid endarterectomy. More than ten international randomized studies have up to now been conducted. Some of them prove the advantage of using either carotid endarterectomy or stenting of carotid arteries, others show equivalence of both methods of treatment. Carotid endarterectomy is currently a preferred operation for carotid artery stenoses, with lower incidence of the development of postoperative strokes and restenoses in the remote period...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29240063/-simultaneous-operation-in-a-patient-with-stenosis-of-the-extracranial-portion-and-an-intracranial-aneurysm-of-the-internal-carotid-artery
#12
A N Kazantsev, R S Tarasov, A I Anufriev, N N Burkov, A R Shabaev, E V Ruban
Presented herein is a clinical case report concerning surgical treatment of a patient with a rare combination of two pathologies, i. e., a haemodynamically significant stenosis of the extracranial portion and a sacciform aneurysm of the communicative portion of the right internal carotid artery on the background of multifocal atherosclerosis. The patient underwent a simultaneous operation consisting in clipping of the sacciform arterial aneurysm of the communicative portion of the right internal carotid artery and carotid endarterectomy on the right...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29239935/the-impact-of-primary-antiphospholipid-syndrome-on-long-term-cardiovascular-outcomes-after-percutaneous-coronary-intervention-and-stenting-in-patients-with-myocardial-infarction
#13
Mauricio Mora-Ramirez, Héctor Gonzalez-Pacheco, Luis M Amezcua-Guerra
Little is known about the incidence of major adverse cardiovascular events (MACEs) in patients with primary antiphospholipid syndrome (PAPS) undergoing percutaneous coronary intervention (PCI) and stenting due to myocardial infarction (MI).We performed a case-control study, nested in a cohort of 7238 patients with MI. Only 5 PAPS patients who underwent PCI and stenting were found, and they were compared with 15 non-antiphospholipid syndrome (APS) patients. A history of MI and stroke was noticeable in PAPS patients despite a lower frequency of traditional cardiovascular risk factors than in control subjects...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29239899/stroke-severity-quantification-by-critical-care-physicians-in-a-mobile-stroke-unit
#14
Maren R Hov, Jo Røislien, Thomas Lindner, Erik Zakariassen, Kristi C G Bache, Volker M Solyga, David Russell, Christian G Lund
BACKGROUND: Cerebral revascularization in acute stroke requires robust diagnostic tools close to symptom onset. The quantitative National Institute of Health Stroke Scale (NIHSS) is widely used in-hospital, whereas shorter and less specific stroke scales are used in the prehospital field. This study explored the accuracy and potential clinical benefit of using NIHSS prehospitally. PATIENTS AND METHODS: Thirteen anesthesiologists trained in prehospital critical care enrolled patients with suspected acute stroke in a mobile stroke unit...
December 12, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29239808/drug-class-renal-elimination-and-outcomes-of-direct-oral-anticoagulants-in-asian-patients-a-meta-analysis
#15
Kang-Ling Wang, Chun-Chih Chiu, Robert P Giugliano, Doreen Su-Yin Tan, Chun-Yi Lin, En-Yu Lai, Shinya Goto, Chern-En Chiang
BACKGROUND: Direct oral anticoagulants (DOACs) have a better risk benefit profile in Asian patients with atrial fibrillation (AF). Whether treatment effects could be modified by drug class and dependency on renal elimination of studied agents has not yet been explored. METHODS: We searched PubMed, CENTRAL, and CINAHL databases through November 2016 for phase III randomized controlled trials comparing DOACs with warfarin in patients with AF. Efficacy and safety outcomes were pooled according to drug class and dependency on renal elimination of DOACs and were compared with the Mantel-Haenszel fixed-effects model...
November 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29239807/an-objective-measurement-of-lacunar-infarct-location-from-the-middle-cerebral-artery-stem
#16
Shanal S Kumar, Bradford A Moffat, Simon Salinas, Leonid Churilov, Bernard Yan
BACKGROUND: There is emerging interest in the relationship between neuroimaging location of lacunar infarcts and underlying stroke risk factors. Recent methods used for localization of lacunar infarcts are affected by high inter-rater variability. We used a novel algorithm-driven method that provided quantitative assessment of the distance of the lacunar infarct from the origins of the lenticulostriate arteries. METHODS: We conducted a retrospective analysis of patients who presented with lacunar infarcts between 2007 and 2011...
November 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29239686/recurrent-posterior-circulation-infarcts-secondary-to-vertebral-artery-external-compression-treated-with-endovascular-deconstruction
#17
Aldo Fabrizio Berti, Atif Zafar, Asad Ikram, Christopher S Calder, Danielle Eckart Sorte
When multiple, recurrent infarcts occur in spite of maximal medical management, the level of suspicion for atypical vascular injury should be heightened. We present a case of a patient who presented with recurrent posterior circulation infarcts despite optimized medical management. On imaging, he was found to have external anatomical vertebral artery muscular and/or osseous compression leading to repetitive vascular injury and strokes. Recurrent intimal injury and vertebral artery to intracranial emboli despite anticoagulation and subsequent dual antiplatelet therapy necessitated definitive operative management...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29239394/quantitative-mr-image-analysis-for-brian-tumor
#18
Zeina A Shboul, Sayed M S Reza, Khan M Iftekharuddin
This paper presents an integrated quantitative MR image analysis framework to include all necessary steps such as MRI inhomogeneity correction, feature extraction, multiclass feature selection and multimodality abnormal brain tissue segmentation respectively. We first obtain mathematical algorithm to compute a novel Generalized multifractional Brownian motion (GmBm) texture feature. We then demonstrate efficacy of multiple multiresolution texture features including regular fractal dimension (FD) texture, and stochastic texture such as multifractional Brownian motion (mBm) and GmBm features for robust tumor and other abnormal tissue segmentation in brain MRI...
2018: VipIMAGE 2017 (2017)
https://www.readbyqxmd.com/read/29239331/ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-are-risk-factors-for-ischemic-stroke-in-patients-with-type-2-diabetes
#19
Ting Li, Xiu-Juan Wu, Xiao-Min Chen, Si-Bo Wang, Kang-Ding Liu, Ying-Qi Xing
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity (BaPWV) and ankle-brachial index (ABI) are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group (n = 55) and a diabetes and ischemic stroke group (n = 62)...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239328/leap-motion-based-virtual-reality-training-for-improving-motor-functional-recovery-of-upper-limbs-and-neural-reorganization-in-subacute-stroke-patients
#20
Zun-Rong Wang, Ping Wang, Liang Xing, Li-Ping Mei, Jun Zhao, Tong Zhang
Virtual reality is nowadays used to facilitate motor recovery in stroke patients. Most virtual reality studies have involved chronic stroke patients; however, brain plasticity remains good in acute and subacute patients. Most virtual reality systems are only applicable to the proximal upper limbs (arms) because of the limitations of their capture systems. Nevertheless, the functional recovery of an affected hand is most difficult in the case of hemiparesis rehabilitation after a stroke. The recently developed Leap Motion controller can track the fine movements of both hands and fingers...
November 2017: Neural Regeneration Research
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