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Isotretinoin

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https://www.readbyqxmd.com/read/29204395/mutilating-keratoderma-with-concomitant-alopecia-and-keratoses-follicularis-spinulosa-decalvans-x-linked-olmsted-syndrome-and-its-response-to-isotretinoin
#1
Gunjan Verma, Kabir Sardana, R K Gautam
We report a case of mutilating keratoderma with alopecia and keratoses follicularis spinulosa decalvans (KFSD), which was initially diagnosed as ectodermal dysplasia and Olmsted syndrome but was revisited as a case of X-linked Olmsted (XLO) syndrome. We focus on this uncommon entity (XLO) to highlight the differentials of alopecia with palmoplantar keratoderma.
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29190629/suppressed-adiponectin-levels-and-increased-adiponectin-response-to-oral-glucose-load-in-lean-women-with-severe-acne-normalizes-after-isotretinoin-treatment
#2
Kadriye Aydin, Fatma Çetinözman, Gonca Elcin, Duygu Yazgan Aksoy, Fatma Ucar, Bulent O Yildiz
BACKGROUND/AIM: Isotretinoin, the drug of choice for severe acne, might be associated with a decrease in insulin sensitivity. Adiponectin is an adipose tissue-derived protein that increases insulin sensitivity. In this study, we aimed to investigate adiponectin levels in postadolescent severe acne and the effect of isotretinoin on adiponectin levels. METHODS: Participants included 18 female patients with severe acne and 18 healthy women matched for age and body mass index (BMI)...
December 1, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29158813/vascularized-tissue-engineered-model-for-studying-drug-resistance-in-neuroblastoma
#3
A Villasante, K Sakaguchi, J Kim, N K Cheung, M Nakayama, H Parsa, T Okano, T Shimizu, G Vunjak-Novakovic
Neuroblastoma is a vascularized pediatric tumor derived from neural crest stem cells that displays vasculogenic mimicry and can express a number of stemness markers, such as SOX2 and NANOG. Tumor relapse is the major cause of succumbing to this disease, and properties attributed to cancer stem-like cells (CSLC), such as drug-resistance and cell plasticity, seem to be the key mechanisms. However, the lack of controllable models that recapitulate the features of human neuroblastoma limits our understanding of the process and impedes the development of new therapies...
2017: Theranostics
https://www.readbyqxmd.com/read/29104042/isotretinoin-treatment-for-acne-and-risk-of-depression-a-systematic-review-and-meta-analysis
#4
Y-C Huang, Y-C Cheng
No abstract text is available yet for this article.
November 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29103005/the-effects-of-microduplication-1q21-1-and-in-utero-isotretinoin-exposure
#5
Sarah Kirsten Taylor, Remy Toko
The impact of in-utero isotretinoin exposure has been widely reported, with many affected pregnancies failing to reach term.(1 2) Due to the low numbers of in-utero isotretinoin exposed pregnancies, the interactions between this drug and rare genetic defects such as microduplication 1q21.1 are unclear, particularly how they might manifest phenotypically. We present this case of in-utero isotretinoin exposure occurring in a child with microduplication 1q21.1. The child was born with congenital abnormalities which did not fit into a single syndrome...
November 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29099437/isotretinoin-induced-angle-closure-and-myopic-shift
#6
Young-Myoung Park, Tae-Eun Lee
PURPOSE: To report and describe the management a rare case of transient bilateral angle closure with increased intraocular pressure (IOP) and myopic shift while on isotretinoin therapy for acne. METHODS: A 28-year-old woman presented with bilateral myopic shift, angle closure with IOP increase, and supraciliary effusion 1 week after acne therapy with isotretinoin. Two weeks after stopping isotretinoin, and treatment with topical prednisolone acetate, atropine, and fixed combination of timolol and dorzolamide, refraction, IOP returned to normal and supraciliary effusions was decreased on ultrasound biomicroscopy...
November 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29063150/drug-safety-in-pregnancy-the-german-embryotox-institute
#7
Katarina Dathe, Christof Schaefer
Since 1988, the German Embryotox institute combines individual counselling of pregnant women and their health care providers (HCP) with research on drug safety in pregnancy. In addition, Embryotox offers web-based information which covers the most important and most frequently requested pharmaceutical substances. In contrast to ready-made drug risk information in package leaflets and other product information, individual counselling considers different clinical settings such as (1) looking for a drug of choice or planning pregnancy under medication, (2) risk assessment of a particular drug that has already been taken during an (unplanned) pregnancy and (3) evaluation of an adverse pregnancy outcome in association with a particular medication...
October 24, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29039999/treatment-and-survival-of-childhood-neuroblastoma-evidence-from-a-population-based-study-in-the-united-states
#8
Diarmuid Coughlan, Matthew Gianferante, Charles F Lynch, Jennifer L Stevens, Linda C Harlan
BACKGROUND: Childhood neuroblastoma describes a heterogeneous group of extracranial solid tumors, that are treated per risk profile. We sought to describe treatment patterns and survival using population-based data from throughout the United States. MATERIALS AND METHODS: Using the National Cancer Institute (NCI)'s Patterns of Care data, we analyzed treatment provided to newly diagnosed, histologically confirmed neuroblastoma patients in 2010 and 2011, registered to one of 14 Surveillance, Epidemiology, and End Results (SEER) cancer registries...
October 17, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29036252/efficacy-of-isotretinoin-and-acitretin-in-treatment-of-frontal-fibrosing-alopecia-retrospective-analysis-of-54-cases
#9
Adriana Rakowska, Agnieszka Gradzińska, Małgorzata Olszewska, Lidia Rudnicka
This study aimed to assess the efficacy of systemic retinoids in treating frontal fibrosing alopecia (FFA). It was based on a retrospective analysis of 54 female patients with FFA treated with: oral isotretinoin at the daily dose of 20 mg (29/54) or acitretin at the daily dose of 20 mg (11/54) or with oral finasteride 5 mg/daily (14/54). The study was conducted between 2007 and 2017. The basic of the study is the measurement of distance between the frontal hairline and the glabellar crease prior to the commencement of treatment and after 6, 12, and 24 months...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29030873/a-feasibility-study-for-a-triple-blind-randomized-controlled-trial-investigating-the-effects-of-oral-isotretinoin-on-mood-and-quality-of-life-in-patients-with-acne-vulgaris
#10
S Rea, S Tucker, V Frittelli, R Gunnarsson
Isotretinoin is used in the treatment of severe acne vulgaris (AV), but has controversially been associated with depression and suicide. Large prospective studies have failed to translate this clinically. We undertook a feasibility study to investigate the parameters of a triple-blind, randomized controlled trial (RCT) assessing the effect of oral isotretinoin on quality of life (QoL) and mood in patients with AV. Patients meeting the inclusion criteria were randomized for 2 weeks to isotretinoin or doxycycline...
October 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28992847/-rhabdomyolysis-after-isotretinoin-treatment-in-a-17-year-old-male
#11
Cecilie Paulsrud, Ida-Marie Stender, Lisbeth Samsø Schmidt
Rhabdomyolysis is a rare, but known complication to treat-ment with systemic isotretinoin in patients with acne and can lead to severe kidney damage. In our case report a 17-year-old male, exercising moderately, developed rhab-domyolysis without kidney injury after two-month treatment with isotretinoin 20 mg daily. He complained of some muscle pain and was treated according to guidelines for rhabdomyolysis with no sequelae. Frequent monitoring of muscle complaints and control of serum creatine kinase in patients with affected liver and kidney function is essential...
October 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28990802/correction-to-cozzolino-et%C3%A2-al-ovarian-stimulation-under-the-effect-of-isotretinoin
#12
(no author information available yet)
No abstract text is available yet for this article.
October 9, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28980413/isotretinoin-administration-improves-sperm-production-in-men-with-infertility-from-oligoasthenozoospermia-a-pilot-study
#13
J K Amory, K A Ostrowski, J R Gannon, K Berkseth, F Stevison, N Isoherranen, C H Muller, T Walsh
There is currently no effective medical therapy for men with infertility due to oligoasthenozoospermia. As men with abnormal sperm production have lower concentrations of 13-cis-retinoic acid in their testes, we hypothesized that men with infertility from oligoasthenozoospermia might have improved sperm counts when treated with isotretinoin (13-cis-retinoic acid). We conducted a single-site, single-arm, pilot study to determine the effect of therapy with isotretinoin on sperm indices in 19 infertile men with oligoasthenozoospermia...
November 2017: Andrology
https://www.readbyqxmd.com/read/28979664/oily-skin-a-review-of-treatment-options
#14
REVIEW
Dawnielle C Endly, Richard A Miller
One of the most common dermatologic concerns is oily skin, and the demand for effective treatment options is ever apparent. This review article addresses numerous topical treatment options such as retinoids, olumacostat glasaretil, and various cosmeceutical agents. several systemic and procedural techniques that incorporate isotretinoin, spironolactone, oral contraceptives, botulinum toxin, photodynamic therapy, and lasers are reviewed as well. Each treatment option is analyzed in terms of the proposed mechanism of action, efficacy reported in the literature, and potential adverse effects...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28972044/neuroblastoma-patients-kir-and-kir-ligand-genotypes-influence-clinical-outcome-for-dinutuximab-based-immunotherapy-a-report-from-the-children-s-oncology-group
#15
Amy K Erbe, Wei Wang, Lakeesha Carmichael, KyungMann Kim, Eneida A Mendonca, Yiqiang Song, Dustin Hess, Patrick K Reville, Wendy B London, Arlene Naranjo, Jacquelyn A Hank, Mitchell B Diccianni, Ralph A Reisfeld, Stephen D Gillies, Katherine K Matthay, Susan L Cohn, Michael D Hogarty, John M Maris, Julie R Park, Mehmet Fevzi Ozkaynak, Andrew Gilman, Alice L Yu, Paul M Sondel
PURPOSE: In 2010, a Children's Oncology Group (COG) phase III randomized trial for high-risk neuroblastoma patients (ANBL0032) demonstrated improved event-free survival (EFS) and overall survival (OS) following treatment with an immunotherapy regimen of dinutuximab, GM-CSF, IL-2, and isotretinoin compared to treatment with isotretinoin alone. Dinutuximab, a chimeric anti-GD2 monoclonal antibody, acts in part via NK cells. Killer Immunoglobulin-like Receptors (KIRs) on NK cells and their interactions with KIR-ligands can influence NK cell function...
October 2, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28942695/ovarian-stimulation-under-the-effect-of-isotretinoin
#16
Mauro Cozzolino, Javier Domingo, Sérgio Reis Soares
Isotretinoin (13-cis-retinoic acid) is a pharmaceutical vitamin A analog that is frequently used in the treatment of severe cystic acne, many women at reproductive age being exposed to this substance. This drug has a clearly documented teratogenicity and data from rodents and humans indicate that a direct aggression to ovarian follicles also occurs. Here we report the case of a 29-year-old woman with breast cancer referred for emergency preservation of reproductive potential that used isotretinoin up to the day before the initiation of ovarian stimulation...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28940619/eruptive-milia-during-isotretinoin-therapy
#17
William Farmer, Kyle Cheng, Kalyani Marathe
Isotretinoin (13-cis-retinoic acid) is a synthetic vitamin A derivative that is effective in the treatment of recalcitrant, nodulocystic acne. To our knowledge, there are no reports in the medical literature of milia as a side effect of isotretinoin. We report a case of eruptive facial milia in the setting of isotretinoin treatment for acne.
September 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28932071/keratosis-follicularis-spinulosa-decalvans-with-associated-mental-retardation-response-to-isotretinoin
#18
Sarita Sanke, Vibhu Mendiratta, Archana Singh, Ram Chander
No abstract text is available yet for this article.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28927457/p53-key-conductor-of-all-anti-acne-therapies
#19
REVIEW
Bodo C Melnik
This review based on translational research predicts that the transcription factor p53 is the key effector of all anti-acne therapies. All-trans retinoic acid (ATRA) and isotretinoin (13-cis retinoic acid) enhance p53 expression. Tetracyclines and macrolides via inhibiting p450 enzymes attenuate ATRA degradation, thereby increase p53. Benzoyl peroxide and hydrogen peroxide elicit oxidative stress, which upregulates p53. Azelaic acid leads to mitochondrial damage associated with increased release of reactive oxygen species inducing p53...
September 19, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28917459/yellow-facial-papules-associated-with-frontal-fibrosing-alopecia-a-distinct-histologic-pattern-and-response-to-isotretinoin
#20
LETTER
Ana Filipa Pedrosa, Ana Filipa Duarte, Eckart Haneke, Osvaldo Correia
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
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