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Isotretinoin

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https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#1
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29644707/perinuclear-antineutrophil-cytoplasmic-antibody-positive-vasculitis-oligoarthritis-tendinitis-and-myositis-associated-with-isotretinoin-in-a-15-year-old-boy-case-report-and-review-of-literature
#2
Thomas C Mangodt, Rik Joos, Vasiliki Siozopoulou, Pieter-Jan Cortoos, Hans Baeten, Martine Docx, Machiel van den Akker
We present a patient in whom a combination of perinuclear antineutrophil cytoplasmic antibody-positive vasculitis, oligoarthritis, tendinitis, and myositis was considered to be associated with isotretinoin use. Discontinuation of the drug resulted in complete clinical and biochemical remission (normalization of perinuclear antineutrophil cytoplasmic antibody titer). Although we were unable to prove causality, no other underlying cause for the patient's course was found. We report this occurrence to bring it to the attention of physicians prescribing isotretinoin...
April 11, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29603591/phase-i-study-of-vorinostat-in-combination-with-isotretinoin-in-patients-with-refractory-recurrent-neuroblastoma-a-new-approaches-to-neuroblastoma-therapy-nant-trial
#3
Navin Pinto, Steven G DuBois, Araz Marachelian, Scott J Diede, Agne Taraseviciute, Julia L Glade Bender, Denice Tsao-Wei, Susan G Groshen, Joel M Reid, Daphne A Haas-Kogan, C Patrick Reynolds, Min H Kang, Meredith S Irwin, Margaret E Macy, Judith G Villablanca, Katherine K Matthay, Julie R Park
BACKGROUND: Vorinostat combined with retinoids produces additive antitumor effects in preclinical studies of neuroblastoma. Higher systemic exposures of vorinostat than achieved in pediatric phase I trials with continuous daily dosing are necessary for in vivo increased histone acetylation and cytotoxic activity. We conducted a phase I trial in children with relapsed/refractory neuroblastoma to determine the maximum tolerated dose (MTD) of vorinostat on an interrupted schedule, escalating beyond the previously identified pediatric MTD...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29590288/depression-screening-in-dermatology-think-isotretinoin
#4
Kory Patrick Schrom, Eliot N Mostow, Terri Nagy
No abstract text is available yet for this article.
March 28, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29577262/galli-galli-disease-responsive-to-isotretinoin-treatment
#5
Elizabeth Dupuy, Serge Alexanian, Jennifer Hsiao
No abstract text is available yet for this article.
March 25, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29575091/transgender-adolescents-and-acne-a-cases-series
#6
Lucía Campos-Muñoz, Diego López-De Lara, Marina L Rodríguez-Rojo, Alberto Conde-Taboada, Eduardo López-Bran
We describe the difficulties of treating acne in a series of female-to-male transgender adolescents, including concerns about potential hepatotoxicity with concomitant use of testosterone with isotretinoin or tetracyclines. Acne is a foreseeable adverse effect of testosterone treatment in transgender adolescents, so monitoring for acne is advised. The treatment of acne in transgender adolescents is important given that severe acne and transgenderism are associated with higher rates of depression and suicide...
March 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29569740/the-medication-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-asians-the-major-drug-causality-and-comparison-to-the-usa-fda-label
#7
Yu-Hsin Wang, Chun-Bing Chen, Wichittra Tassaneeyakul, Yoshiro Saito, Michiko Aihara, Siew Eng Choon, Haur Yueh Lee, Mimi Mee Chang, Francisca D Roa, Cheng-Wei Wu, Jing Zhang, Nontaya Nakkam, Parinya Konyoung, Yoshimi Okamoto-Uchida, Christina Man-Tung Cheung, Jin-Wen Huang, Chao Ji, Bo Cheng, Rosaline Chung-Yee Hui, Chia-Yu Chu, Yi-Ju Chen, Ching-Ying Wu, Chao-Kai Hsu, Tsu-Man Chiu, Hsin-Chun Ho, Jing-Yi Lin, Chih-Hsun Yang, Ya-Ching Chang, Shih-Chi Su, Chuang Wei Wang, Wen-Hung Chung
Specific ethnic genetic backgrounds associated with risk of Stevens-Johnson syndrome/toxic epidermal necrolysis(SJS/TEN) especially in Asians. However, there have been no large cohort, multiple-country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998-2017. A total 1028 SJS/TEN cases were identified by ALDEN. Furthermore, those medications labeled by USFDA as carrying a risk of SJS/TEN were also compared to the common causes of SJS/TEN in Asian countries...
March 23, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29564872/reducing-the-oral-isotretinoin-skin-side-effects-efficacy-of-8-omega-ceramides-hydrophilic-sugars-5-niacinamide-cream-compound-in-acne-patients
#8
Maria V Cannizzaro, Annunziata Dattola, Virginia Garofalo, Ester Del Duca, Luca Bianchi
BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment...
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29558234/development-of-a-stability-indicating-uplc-method-for-determination-of-isotretinoin-in-bulk-drug
#9
Shih-Liang Hsi, Peter Surman, Raida Al-Kassas
A highly sensitive and rapid stability indicating Ultra Performance Liquid Chromatographic (UPLC) method was developed for the quantification and identification of isotretinoin in bulk. Chromatographic separation was developed using a gradient elution in a reversed-phase system at flow rate of 0.5 ml/min with 12 minutes run time. The mobile phase was a gradient mixture of mobile phase A (contained a 30:70:0.5 mixture solution of methanol/Purified water/Glacial Acetic Acid) and mobile phase B (contained a 70:25:4...
March 20, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29557621/-isotretinoin-embryopathy-an-entity-that-can-be-avoided
#10
Francisco Cammarata-Scalisi, Dairelis Nieves, Andrea Avendaño, María A Lacruz-Rengel, Karelys Alviárez, Francys Dávila, Izzet Yavuz, Michele Callea
Isotretinoin is the most effective drug in the treatment of severe recalcitrant nodulocystic acne. However, treatment with this drug is associated with adverse effects, the most severe being teratogenesis. It has been estimated that 40% of pregnancies exposed to isotretinoin present spontaneous abortion and 35% develop embryopathy. We present the case of a newborn with a history of prenatal exposure to isotretinoin, a clinical entity that can be avoided, with severe congenital defects in the central nervous system and important facial dysmorphisms, with unfavorable clinical course...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29551370/treating-isotretinoin-associated-cheilitis-with-hydrocortisone-containing-lip-balm
#11
Brett C Neill, Christopher D Willis, John A Neill, Cody Hanson, Anand Rajpara, Daniel J Aires
No abstract text is available yet for this article.
March 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29542350/pharmacotherapy-of-retinal-disease-with-visual-cycle-modulators
#12
Rehan M Hussain, Ninel Z Gregori, Thomas A Ciulla, Byron L Lam
Pharmacotherapy with visual cycle modulators (VCMs) is under investigation for retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt macular dystrophy (SMD) and nonexudative age-related macular degeneration (AMD), all blinding diseases that lack effective treatment options. Areas covered: The authors review investigational VCMs, including oral retinoids, 9-cis-retinyl-acetate (zuretinol) and 9-cis-β-carotene, which restore 11-cis-retinal levels in RP and LCA caused by LRAT and RPE65 gene mutations, and may improve visual acuity and visual fields...
March 15, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29537444/efficacy-and-safety-of-adapalene-0-3-benzoyl-peroxide-2-5-gel-plus-oral-doxycycline-in-subjects-with-severe-inflammatory-acne-who-are-candidates-for-oral-isotretinoin
#13
James Q Del Rosso, Linda Stein Gold, Sandra Marchese Johnson, Maria Jose Rueda, Hilary Baldwin, Edward L Lain, Megan Landis, Marta Rendon, Emil Tanghetti, Jonathan Weiss
INTRODUCTION: Acne treatment guidelines suggest a combination approach with topical therapy including a topical retinoid, benzoyl peroxide and an oral antibiotic, or oral isotretinoin (OI), as first-line treatment options for severe acne vulgaris (AV). This study evaluated the efficacy and safety of a daily regimen of 0.3% adapalene and 2.5% benzoyl peroxide (0.3% A/BPO) gel and oral doxycycline 100 mg twice daily in severe (nonnodulocystic, non-conglobate) inflammatory AV. METHODS: This was a phase 4, 12-week, single-arm, openlabel, multi-center investigational study...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29512421/isotretinoin-induced-urethritis-versus-non-gonococcal-urethritis-in-a-man-who-has-sex-with-men-an-open-debate
#14
Rami A Ballout, Ismael Maatouk
This is the case of a young man presenting with urethritis despite a negative infectious work-up. Careful history taking elucidated a strong correlation between symptom onset and a recent dose escalation of isotretinoin for treatment of his refractory cystic acne. The urethral symptoms quickly resolved with dose reduction, suggesting urethritis as a rare adverse reaction of isotretinoin.
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29512201/isotretinoin-treatment-and-peanut-allergy-a-new-case-report-and-review-of-the-literature
#15
C Paugam, M Saint-Jean, L Colas, C Bernier, B Dréno
Isotretinoin is a common and effective retinoid drug that remains the gold standard for the treatment of severe acne. The package leaflet clearly mentions its contraindication in patients with peanut and/or soya allergy. As isotretinoin is solubilized in refined soya oil, it is contraindicated in patients with soya IgE mediated allergy. Because of possible cross-reactivity, concerns have been raised about giving the drug to patients presenting with peanut allergy. This article is protected by copyright. All rights reserved...
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29508918/a-comparative-review-of-the-isotretinoin-pregnancy-risk-management-programs-across-four-continents
#16
REVIEW
Tom Kovitwanichkanont, Tim Driscoll
Isotretinoin has revolutionized the treatment of severe acne vulgaris, a condition which if left untreated may result in significant socio-psychological implications for those affected. Timely access to isotretinoin therapy is important to avoid the risks of potential physical and emotional scarring. However, due to its high risks of teratogenicity, isotretinoin must be used with care in females of childbearing potential. Since isotretinoin's introduction, numerous risk management programs have been implemented across the world in an attempt to prevent isotretinoin use in pregnancy...
March 6, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29491653/standard-guidelines-of-care-performing-procedures-in-patients-on-or-recently-administered-with-isotretinoin
#17
Venkataram Mysore, Omprakash H Mahadevappa, Shyamanta Barua, Imran Majid, Vishalakshi Viswanath, Ramesh M Bhat, Suresh Talwar, Salim Thurakkal, Sanjeev J Aurangabadkar, Manas Chatterjee, Anil Ganjoo
Background: Currently, the standard protocol regarding the performance of procedures on patients receiving or having recently received isotretinoin (13- cis -retinoic acid) states that the procedures should not be performed. The recommendations in standard books and drug insert require discontinuation of isotretinoin for 6 months before performing cosmetic procedures, including waxing, dermabrasion, chemical peels, laser procedures, or incisional and excisional cold-steel surgery. These recommendations have been followed for over two decades despite little evidence for the stated increased risk of scarring...
October 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29488816/a-2017-update-challenging-the-cosmetic-procedural-delay-following-oral-isotretinoin-therapy
#18
Katherine Ann McDonald, Amanda Jane Shelley, Tadeusz Pierscianowski, Afsaneh Alavi
For decades it has been widely accepted that elective procedures should be delayed for at least 6-months following completion of isotretinoin therapy. However, numerous 2017 publications demonstrate the need for change in best practice. The evidence has yet to be succinctly summarized in a single article or in a stand-alone quick reference algorithm for physicians. This article's review of all 2017 publications confirms that the 6-month delay is not necessary for all procedures and provides a simple algorithmic approach to summarize the updated recommendations for procedural delay of cosmetic procedures following systemic isotretinoin therapy...
February 28, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29480033/dermatological-indications-for-the-use-of-isotretinoin-beyond-acne
#19
E Forbat, F R Ali, F Al-Niaimi
Whilst the use of isotretinoin has revolutionized the treatment of acne vulgaris, isotretinoin is increasingly recognized as a useful therapeutic option for many other cutaneous conditions. We review the evidence underlying the use of isotretinoin for a variety of dermatological indications including hidradenitis suppurativa, sebaceous gland pathology, rosacea, scarring alopecia, cosmetic dermatology and non-melanoma skin cancer prophylaxis amongst other uses, and thus consider alternative uses within dermatology practice...
February 26, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29477732/isotretinoin-therapy-a-retrospective-cohort-analysis-of-completion-rates-and-factors-associated-with-non-adherence
#20
Tiana Kazemi, Suzanne M Sachsman, Holly M Wilhalme, Carolyn Goh
No abstract text is available yet for this article.
February 22, 2018: Journal of the American Academy of Dermatology
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