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Isotretinoin

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https://www.readbyqxmd.com/read/27895437/isotretinoin-increased-carotid-intima-media-thickness-in-acne-patients
#1
A Saklamaz, B Uyar, M Yalcin, H Cengiz
BACKGROUND: Isotretinoin (Iso) in acne treatment may cause dyslipidemia and increase in liver enzymes. Moreover, its effect on lipid and glucose metabolism may induce atherosclerotic complications. The aim of this study was to evaluate carotid intima-media thickness (CIMT), osteopontin (OPN), lipid, high sensitive C-reaktive protein (hs-CRP) levels, and insulin resistance (HOMA-IR) in acne patients before and after Iso treatment. MATERIALS: Twenty-one acne patients were treated with Iso (0...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27869375/aktueller-stand-der-systemischen-rosazea-therapie
#2
M Schaller, H Schöfer, B Homey, U Gieler, P Lehmann, T A Luger, T Ruzicka, M Steinhoff
Basierend auf den Daten zahlreicher Studien sind orale Tetracycline - und hier insbesondere Doxycyclin als Tetracyclin der zweiten Generation - die Grundpfeiler der systemischen Rosazea-Therapie. Bisher ist dafür jedoch nur Doxycyclin 40 mg in antientzündlicher Dosierung mit veränderter Wirkstofffreisetzung zugelassen. Seit Einführung der Therapie mit Doxycyclin einmal täglich in nicht antibiotischer Dosierung wird die orale Therapie häufiger als Erstbehandlung bei mittelschwerer bis schwerer papulopustulöser Rosazea verschrieben...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27869374/state-of-the-art-systemic-rosacea-management
#3
M Schaller, H Schöfer, B Homey, U Gieler, P Lehmann, T A Luger, T Ruzicka, M Steinhoff
Based on numerous trials, oral tetracyclines and most commonly their second-generation derivative doxycycline have become the main pillar in systemic rosacea treatment. However, the only preparation that has been approved so far in this setting is 40 mg doxycycline in an anti-inflammatory dosage and with a modified release formulation. With the introduction of this once-daily, non-antibiotic dosing of doxycycline, oral therapy is more commonly prescribed as first-line treatment in moderate to severe papulopustular rosacea...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27867744/iga-pemphigus-showing-iga-antibodies-to-desmoglein-1-and-3
#4
Salama Hegazy, Sana Bouchouicha, Aida Khaled, Lilia Laadher, Maryem Kallel Sellami, Faten Zeglaoui
BACKGROUND: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). CASE REPORT: We report the case of an 60-year-old man with intraepidermal neutrophilic IgA pemphigus with IgA antibodies to Dsg1 and Dsg3. Histologic examination revealed subcorneal neutrophilic pustules with few acantholytic cells...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27853192/doxycycline-metronidazole-and-isotretinoin-do-they-modify-microrna-mrna-expression-profiles-and-function-in-murine-t-cells
#5
Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Claudia Stanzel, Pedro A Ruiz Castro, Gerhard Rogler, Isabelle Frey-Wagner
Inflammatory bowel disease (IBD) may develop due to an inflammatory response to commensal gut microbiota triggered by environmental factors in a genetically susceptible host. Isotretinoin (acne therapy) has been inconsistently associated with IBD onset and flares but prior treatment with antibiotics, also associated with IBD development, complicates the confirmation of this association. Here we studied in mice whether doxycycline, metronidazole or isotretinoin induce epigenetic modifications, and consequently change T-cell mRNA expression and/or function directly after treatment and after a 4 week recovery period...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27843919/rosacea-management
#6
REVIEW
Manal Abokwidir, Steven R Feldman
BACKGROUND: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. PURPOSE: To review the different kinds of management for all subtypes. METHODS: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. RESULTS: Flushing is better prevented rather than treated, by avoiding specific triggers, decreasing transepidermal water loss by moisturizers, and blocking ultraviolet light...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27820130/prolonged-isotretinoin-in-ultra-high-risk-neuroblastoma
#7
Thomas Cash, Adina Alazraki, Muna Qayed, Howard M Katzenstein
Patients with high-risk neuroblastoma remain a therapeutic challenge with significant numbers of patients failing to respond sufficiently to initial therapy. These patients with poor response to induction are considered as ultra high-risk and are in need of novel treatment strategies. Isotretinoin is part of the standard of care treatment for patients with high-risk disease who undergo high-dose chemotherapy with autologous stem cell rescue although some have questioned the optimal administration schedule. Prolonged use of isotretinoin was well tolerated and may have contributed to long-term survival in a group of patients with ultra high-risk neuroblastoma...
November 4, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27816123/consensus-based-acne-classification-system-and-treatment-algorithm-for-spain
#8
J L López-Estebaranz, P Herranz-Pinto, B Dréno
Acne is a chronic inflammatory disease whose psychosocial effects can greatly impair quality of life. Various scales are used to classify the severity of acne, and several treatment algorithms are currently applied: no consensus on a common scale or treatment guidelines has been reached. A group of Spanish experts therefore met to identify a scale the majority could accept as the most appropriate for classifying severity and treating accordingly. The group chose the following classifications: comedonal acne, mild or moderate papulopustular acne, severe papulopustular acne, moderate nodular acne, and nodular-cystic acne (or acne tending to leave scars)...
November 2, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27796155/investigation-of-the-effects-of-systemic-isotretinoin-treatment-on-retinal-nerve-fiber-layer-and-macula
#9
Uğur Yılmaz, Erkut Kucuk, Cagdas Koc, Ayse Ozkose
PURPOSE: To investigate the effects of systemic isotretinoin therapy on retina by measuring retinal nevre fiber layer(RNFL) and macular thicknesses. METHOD: This prospective, cross-sectional study was conducted in patients prescribed systemic isotretinoin therapy. 72 eyes of 36 patients were included in the study. The patients were followed during three months. Detailed opthalmologic examination including anterior and posterior segment examination, best corrected visual acuity and intraocular pressure measurement, RNFL and macular thicknesses measurement by Spectral Domain Cirrus Optical Coherence Tomography Model 400 (Carl Zeiss Meditech, Jena, Germany) were performed at baseline, first, second and third months after the beginning of systemic isotretinoin therapy in ophthalmology clinic...
October 31, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27785852/severe-osteoarticular-involvement-in-isotretinoin-triggered-acne-fulminans-two-cases-successfully-treated-with-anakinra
#10
T Oranges, A Insalaco, A Diociaiuti, C Carnevale, R Strippoli, G Zambruno, P Tomà, M El Hachem
Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia(1) . Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in synovitis - acne - pustulosis - hyperostosis and osteitis (SAPHO) syndrome(2,3) . SAPHO is an autoinflammatory disease characterized by osteoarticular and cutaneous manifestations, the latter including nodular and fulminans acne, hidroadenitis suppurativa, and palmo-plantar pustolosis(3) ...
October 27, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27778328/low-dose-oral-isotretinoin-for-moderate-to-severe-seborrhea-and-seborrheic-dermatitis-a-randomized-comparative-trial
#11
Cristhine de Souza Leão Kamamoto, Adriana Sanudo, Karime M Hassun, Ediléia Bagatin
BACKGROUND: The efficacy of low-dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies. OBJECTIVES: This study was designed to determine the efficacy and safety of low-dose oral isotretinoin in the treatment of moderate to severe seborrhea and seborrheic dermatitis on the scalp and/or face. METHODS: A randomized, comparative clinical trial, using two groups, was conducted over 6 months...
October 25, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27765163/isotretinoin-induced-elkonyxis
#12
F Allegue, D González-Vilas, A Zulaica
No abstract text is available yet for this article.
October 17, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27764978/the-prevalence-of-sacroiliitis-in-patients-with-acne-vulgaris-using-isotretinoin
#13
Leyla Baykal Selçuk, Deniz Aksu Arıca, Hanife Baykal Şahin, Savas Yaylı, Sevgi Bahadır
BACKGROUND/OBJECTIVE: Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit in the skin. Isotretinoin is a synthetic vitamin A derivative regarded as the most effective agent in the treatment of acne. There have recently been increasing reports of adverse effects of isotretinoin on the skeletal system. Our aim in this study was to evaluate the rheumatic side-effects triggered by this drug, and particularly the prevalence of sacroiliitis. MATERIALS AND METHODS: A total of 73 patients receiving isotretinoin due to moderate or severe acne vulgaris were included...
November 16, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27738837/utilizing-non-ablative-fractional-photothermolysis-prior-to-ala-photodynamic-therapy-in-the-treatment-of-acne-vulgaris-a-case-series
#14
Sarah Qureshi, Jennifer Y Lin
Aminolevulinic acid (ALA) photodynamic therapy (PDT) is an emerging modality in the treatment of acne. While ablative fractional lasers have been used to enhance drug delivery into the epidermis, recent evidence suggests that non-ablative fractional photothermolysis may also improve uptake of ALA. We explored the use of non-ablative 1550 nm laser as a safe alternative in the delivery of ALA prior to red-light PDT for refractory inflammatory and cystic acne. Subjects referred for treatment of acne refractory to several topical and oral regimens, including isotretinoin, were pre-treated with non-ablative fractional photothermolysis (NAFP)...
October 14, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27730042/sapho-syndrome-with-acne-fulminans-and-severe-polyosteitis-involving-axial-skeleton
#15
B Lakshmi Divya, P Narasimha Rao
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the face with pain at both the wrists and lower back associated with high-grade fever and chills. On physical examination, he had severe tenderness at both wrist joints and lower back, along with swelling of right wrist...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27730033/a-randomized-comparative-trial-of-two-low-dose-oral-isotretinoin-regimens-in-moderate-to-severe-acne-vulgaris
#16
Daulat Ram Dhaked, Ram Singh Meena, Anshul Maheshwari, Uma Shankar Agarwal, Saroj Purohit
BACKGROUND: Oral isotretinoin is highly effective in all forms and grades of acne, even in lower dosages (<0.5 mg/kg/day). There is a paucity of comparative data on the various low-dose regimens of oral isotretinoin in the Indian literature. OBJECTIVES: To assess and compare the efficacy and tolerability of two low-dose oral isotretinoin treatment regimens (20 mg daily and 20 mg alternate days) in moderate to severe acne vulgaris. MATERIALS AND METHODS: A total of 240 patients with moderate to severe acne vulgaris were selected and randomized into two groups and treated with a fixed dose of 20 mg of isotretinoin (Group A - daily and Group B - alternate days) for 24 weeks and followed up for 12 weeks post therapy...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27721552/isotretinoin-induced-acute-severe-myopathy-involving-pelvic-girdle-muscles-a-case-report
#17
Farah Sameem, Semira
Oral isotretinoin has been in widespread use for more than three decades. It causes numerous side effects; skin and mucous membrane being commonly involved. Musculoskeletal adverse effects are also known to occur, but pelvic girdle myopathy is rarely reported. We report myopathy involving pelvic girdle muscles in a young male who received oral isotretinoin for folliculitis decalvans.
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27703816/sudden-appearance-of-indurated-erythematous-plaques-on-a-man-s-face
#18
A Carter, K Viswanathan, K Shulman
Rosacea fulminans (RF), previously known as pyoderma faciale, is a rare presentation of rosacea mostly seen in young women. RF is seen very rarely in men. We present below a case of a fifty-year-old male who presented with RF and was successfully treated with a combination of corticosteroids and isotretinoin.
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/27699859/acne-fulminans-case-series-and-review-of-the-literature
#19
Abdullah Alakeel, Marie Ferneiny, Nicole Auffret, Christine Bodemer
Acne fulminans (AF) is a rare manifestation and the most severe form of the entire clinical spectrum of acne. The disease is destructive and is characterized by the sudden onset of painful and ulcerative pustules and systemic symptoms including high fever, hepatomegaly, polyarthralgia, leukocytosis, plaquetose, and increased inflammatory markers and transaminases. Osteolytic lesions in multiple skeletal sites could also be associated. The use of isotretinoin is considered a related trigger, as well as the use and cessation of testosterone, although a bacterial infection, a drug-induced disease, or an intake of anabolic androgenic steroids has been suggested...
October 4, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27671426/apoptosis-may-explain-the-pharmacological-mode-of-action-and-adverse-effects-of-isotretinoin-including-teratogenicity
#20
Bodo C Melnik
Isotretinoin (13-cis retinoic acid) is the most effective sebum-suppressive drug for the treatment of severe acne. Its effect depends on sebocyte apoptosis, which results from isotretinoin-induced expression of the apoptotic protein tumour necrosis factor-related apoptosis-inducing ligand, insulin-like growth factor-binding protein-3 and neutrophil gelatinase-associated lipocalin. This review proposes that the pharmacological mode of action of isotretinoin in the treatment of severe acne, acute promyelocytic leukaemia, and neuroblastoma results from apoptosis...
September 27, 2016: Acta Dermato-venereologica
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