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https://www.readbyqxmd.com/read/27863633/intersurgical-interval-increased-with-use-of-quadrivalent-human-papillomavirus-vaccine-gardasil-in-a-pediatric-patient-with-recurrent-respiratory-papillomatosis-a-case-report
#1
Maraya M Baumanis, Charles A Elmaraghy
This is a case of a 4 year old female with recalcitrant recurrent respiratory papillomatosis with decreasing intersurgical interval that had improvement in clinical course after administration of the quadrivalent HPV vaccine.
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27803416/two-cases-of-acute-disseminated-encephalomyelitis-following-vaccination-against-human-papilloma-virus
#2
Kenji Sekiguchi, Naoko Yasui, Hisatomo Kowa, Fumio Kanda, Tatsushi Toda
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27771183/manufacturing-costs-of-hpv-vaccines-for-developing-countries
#3
Chaevia Clendinen, Yapei Zhang, Rebecca N Warburton, Donald W Light
BACKGROUND: Nearly all of the 500,000 new cases of cervical cancer and 270,000 deaths occur in middle or lower income countries. Yet the two most prevalent HPV vaccines are unaffordable to most. Even prices to Gavi, the Vaccine Alliance, are unaffordable to graduating countries, once they lose Gavi subsidies. Merck and Glaxosmithkline (GSK) claim their prices to Gavi equal their manufacturing costs; but these costs remain undisclosed. We undertook this investigation to estimate those costs...
October 19, 2016: Vaccine
https://www.readbyqxmd.com/read/27737666/experiences-and-lessons-learned-from-29-hpv-vaccination-programs-implemented-in-19-low-and-middle-income-countries-2009-2014
#4
Joël Ladner, Marie-Hélène Besson, Etienne Audureau, Mariana Rodrigues, Joseph Saba
BACKGROUND: Cervical cancer is the greatest cause of age-weighted years of life lost in the developing world. Human papillomavirus (HPV) infection is associated with a high proportion of cervical cancers, and HPV vaccination may help to reduce the incidence of cancer. The aim of the study was to identify barriers, obstacles, and strategies and to analyze key concerns and lessons learned with respect to the implementation of HPV vaccination program in low- and middle-income countries. METHODS: The Gardasil Access Program (GAP) is a donation program established to enable organizations and institutions in eligible low-resource countries to gain operational experience designing and implementing HPV vaccination programs...
October 13, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27659388/-condydav-a-multicentre-observational-study-of-patients-presenting-external-genital-warts-in-france
#5
J Chanal, S Fouéré, F Yassir-Oria, N Spenatto, F Bouscarat, E Picot, P Martinet, C Vernay-Vaisse, F Pelletier, C Courtieu, V Baclet, C Bernier, D Aymar-Moulene, F Dupuis-Fourdan, A Passeron, C Bara-Passot, A-L Pinault, L Misery, M Janier, N Dupin
BACKGROUND: Since 2007 in France, human papilloma virus (HPV) vaccination has been licensed for use as a vaccine against HPV 6, 11, 16 and 18. The impact on the epidemiology of external genital warts (EGWs) in a large population remains unclear. OBJECTIVES: To determine epidemiologic and clinical features of patients presenting EGWs in France in the era of HPV vaccination. PATIENTS AND METHODS: In this prospective, observational study, we analyzed clinical features and treatments between January 1st, 2012 and March 31, 2012 for patients consulting for EGWs at 15 STI clinics throughout France...
September 19, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27644649/human-papillomavirus-infection-and-its-vaccines-knowledge-and-attitudes-of-primary-health-clinic-nurses-in-kelantan-malaysia
#6
K Jeyachelvi, S Juwita, D Norwati
BACKGROUND: Cervical cancer though preventable is still the leading cause of cancer death among women secondary to breast cancer. Persistent infection with HPV has been causally linked to the disease. A school based HPV vaccination program was introduced in late 2010 in Malaysia and nurse support is essential for its success. OBJECTIVES: To determine nurses knowledge and attitudes about HPV infection and its vaccines, and factors associated with their knowledge...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27511896/quadrivalent-human-papillomavirus-hpv-vaccine-induces-hpv-specific-antibodies-in-the-oral-cavity-results-from-the-mid-adult-male-vaccine-trial
#7
Ligia A Pinto, Troy J Kemp, B Nelson Torres, Kimberly Isaacs-Soriano, Donna Ingles, Martha Abrahamsen, Yuanji Pan, Eduardo Lazcano-Ponce, Jorge Salmeron, Anna R Giuliano
BACKGROUND: Human papillomavirus virus type 16 (HPV-16) and HPV-18 cause a large proportion of oropharyngeal cancers, which are increasing in incidence among males, and vaccine efficacy against oral HPV infections in men has not been previously evaluated. METHODS: Sera and saliva collected in mouthwash and Merocel sponges at day 1 and month 7 were obtained from 150 men aged 27-45 years from Tampa, Florida, and Cuernavaca, Mexico, who received Gardasil at day 1 and months 2 and 6...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27503625/severe-somatoform-and-dysautonomic-syndromes-after-hpv-vaccination-case-series-and-review-of-literature
#8
Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi
Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil(®) and Cervarix(®). Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our "Second Opinion Medical Network" for the evaluation of "neuropathy with autonomic dysfunction" after HPV vaccination...
August 9, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27481200/-the-importance-of-hpv-vaccination-in-men
#9
Borek Sehnal, Roman Chlíbek, Jiří Sláma
The important goal of immunization programs in many countries is the reduction of the incidence of cervical cancer using either the quadrivalent (Silgard/Gardasil) or the bivalent (Cervarix) HPV (human papillomavirus) vaccine. Nevertheless, HPV infection is associated with the development of cancers of anus, vagina, vulva and penis, and cancers of the head and neck and genital warts, too. Large trials for both vaccines find efficacy against HPV-related infection and different HPV associated diseases.Infection with HPV and diseases caused by HPV are common in boys and men, too...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27465467/phospholipid-supplementation-can-attenuate-vaccine-induced-depressive-like-behavior-in-mice
#10
Shaye Kivity, Maria-Teresa Arango, Nicolás Molano-González, Miri Blank, Yehuda Shoenfeld
Human papillomavirus vaccine (HPVv) is used worldwide for prevention of infection. However several reports link this vaccine, with immune-mediated reactions, especially with neurological manifestations. Our previous results showed that HPVv-Gardasil and aluminum-immunized mice developed behavioral impairments. Studies have shown a positive effect of phospholipid supplementation on depression and cognitive functions in mice. Therefore, our goal was to evaluate the effect of a dietary supplement on vaccine-induced depression...
July 27, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27421722/behavioral-abnormalities-in-female-mice-following-administration-of-aluminum-adjuvants-and-the-human-papillomavirus-hpv-vaccine-gardasil
#11
Rotem Inbar, Ronen Weiss, Lucija Tomljenovic, Maria-Teresa Arango, Yael Deri, Christopher A Shaw, Joab Chapman, Miri Blank, Yehuda Shoenfeld
Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals. We sought to evaluate the effects of Al adjuvant and the HPV vaccine Gardasil versus the true placebo on behavioral and inflammatory parameters in female mice. Six-week-old C57BL/6 female mice were injected with either, Gardasil, Gardasil + pertussis toxin (Pt), Al hydroxide, or, vehicle control in amounts equivalent to human exposure...
July 16, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27421720/pancreatitis-after-human-papillomavirus-vaccination-a-matter-of-molecular-mimicry
#12
Mojca Bizjak, Or Bruck, Sonja Praprotnik, Shani Dahan, Yehuda Shoenfeld
A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil(®)). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elevated pancreatic enzymes, and with concomitant abdominal pain and vomiting, he was diagnosed with acute pancreatitis. This case of acute pancreatitis after HPV vaccination is not a novel entity...
July 16, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27406936/immunogenicity-and-persistence-of-immunity-of-a-quadrivalent-human-papillomavirus-hpv-vaccine-in-immunocompromised-children
#13
C Raina MacIntyre, Peter Shaw, Fiona E Mackie, Christina Boros, Helen Marshall, Michelle Barnes, Holly Seale, Sean E Kennedy, Aye Moa, Andrew Hayen, Abrar Ahmad Chughtai, Edward V O'Loughlin, Michael Stormon
AIM: The aim of this study was to determine the immunogenicity and reactogenicity of HPV vaccine in immunocompromised children. METHODS: A multi-centre clinical trial was conducted in three paediatric hospitals in Australia. Unvaccinated children 5-18years of age attending one of three paediatric hospitals with a range of specified conditions associated with immunosuppression were included. Quadrivalent HPV vaccine (Gardasil) was given to the participants and serum anti-HPV antibody levels were measured at baseline (before first dose), 7 and 24months after the first dose of vaccine...
August 5, 2016: Vaccine
https://www.readbyqxmd.com/read/27406735/quadrivalent-human-papillomavirus-vaccine-and-autoimmune-adverse-events-a-case-control-assessment-of-the-vaccine-adverse-event-reporting-system-vaers-database
#14
David A Geier, Mark R Geier
Gardasil is a quadrivalent human papillomavirus (HPV4) vaccine that was approved for use by the US Food and Drug Administration in June 2006. HPV4 vaccine is routinely recommended for administration to women in the USA who are 11-12 years old by the Advisory Committee on Immunization Practices. Previous studies suggest HPV4 vaccine administration was associated with autoimmune diseases. As a consequence, an epidemiological assessment of the vaccine adverse event reporting system database was undertaken for adverse event reports associated with vaccines administered from 2006 to 2014 to 6-39 year-old recipients with a listed US residence and a specified female gender...
July 13, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27366939/an-estimate-of-the-public-health-impact-and-cost-effectiveness-of-universal-vaccination-with-a-9-valent-hpv-vaccine-in-germany
#15
Nathalie Largeron, Karl Ulrich Petry, Jorge Jacob, Florence Bianic, Delphine Anger, Mathieu Uhart
INTRODUCTION: Since 2007, the German Standing Vaccination Committee recommends HPV vaccination for girls aged 12-17 with a 2- (Cervarix®) or 4-valent (Gardasil®) vaccine. A 9-valent vaccine (Gardasil 9®) recently received a European market authorization in 2015. METHODS: A dynamic transmission model was calibrated to the German setting and used to estimate costs and QALYs associated with vaccination strategies. RESULTS: Compared to the current vaccination program, the 9-valent vaccine extended to boys shows further reductions of 24% in the incidence of cervical cancer, 30% and 14% in anal cancer for males and females, as well as over a million cases of genital warts avoided after 100 years...
July 1, 2016: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/27329199/immunotherapy-for-human-papillomavirus-associated-disease-and-cervical-cancer-review-of-clinical-and-translational-research
#16
REVIEW
Sung Jong Lee, Andrew Yang, T C Wu, Chien Fu Hung
Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic agents. However, despite the various treatments utilized for the treatment of cervical cancer, its disease burden remains a global issue. Persistent infection of human papillomavirus (HPV) has been identified as an essential step of pathogenesis of cervical cancer and many other cancers, and nation-wide HPV screening as well as preventative HPV vaccination program have been introduced globally...
September 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27188508/immunological-response-to-quadrivalent-hpv-vaccine-in-treatment-of-recurrent-respiratory-papillomatosis
#17
Robin E A Tjon Pian Gi, Michel R M San Giorgi, Michael Pawlita, Angelika Michel, Bettien M van Hemel, Ed M D Schuuring, Edwin R van den Heuvel, Bernard F A M van der Laan, Frederik G Dikkers
Aim of this study was to explore influence of the quadrivalent HPV vaccine (Gardasil(®)) on the immune status of recurrent respiratory papillomatosis (RRP) patients. In retrospective observational study, six RRP patients who received the quadrivalent HPV vaccine and whose HPV seroreactivity was measured were included. Multiplex HPV Serology was used to determine HPV-specific antibodies pre- and post-vaccination. Surgical interventions and patient records were analyzed. Five HPV6 and 1 HPV11 infected patient were included...
October 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27138671/the-costs-of-delivering-human-papillomavirus-vaccination-to-grade-4-learners-in-kwazulu-natal-south-africa
#18
Indres Moodley, Nerisha Tathiah, Ben Sartorius
BACKGROUND: The national human papillomavirus (HPV) vaccination roll-out in South Africa provides two doses of Cervarix to all female Grade 4 learners in state schools. This study estimated the costs of vaccinating all learners in KwaZulu-Natal Province (females or males and females) using either the two- or three-dose strategies for both the bivalent and quadrivalent vaccines. OBJECTIVE: To determine costs of the HPV vaccination programme in KwaZulu-Natal. METHODS: Costs were determined adapting World Health Organization vaccination costing guidelines...
May 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27137484/develpoment-of-human-papillomavirus-hpv-vaccines-a-review-of-literature-and-clinical-update
#19
Vikrant Chadrakant Sangar, Balasaheb Ghongane, Gaurav Mathur
The casual relationship concerning Human papillomaviruses (HPV) and cervical cancer already established. Therefore, such HPV-associated malignancies might be prevented by prophylactic HPV vaccines. From 2009, two prophylactic HPV L1 Virus-Like Particle vaccines namely, Gardasil® - quadrivalent (Merck) and Cervarix™ - bivalent (GlaxoSmithKline) are widely commercially available. By Aug 2014, 58 countries had introduced HPV vaccination in their national immunization program; this has led to numerous publications on safety and real world effectiveness...
May 2, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27113165/characterization-of-serum-antibodies-from-women-immunized-with-gardasil-a-study-of-hpv-18-infection-of-primary-human-keratinocytes
#20
Hsu-Kun Wang, Qing Wei, Zina Moldoveanu, Warner K Huh, Huong Lan Vu, Thomas R Broker, Jiri Mestecky, Louise T Chow
The prevalent human papillomaviruses (HPVs) infect human epithelial tissues. Infections by the mucosotropic HPV genotypes cause hyperproliferative ano-genital lesions. Persistent infections by high-risk (HR) HPVs such as HPV-16, HPV-18 and related types can progress to high grade intraepithelial neoplasias and cancers. Prophylactic HPV vaccines are based on DNA-free virus-like particles (VLPs) composed of the major capsid protein L1 of HPV-16, -18, -6 and -11 (Gardasil) or HPV-16 and -18 (Cervarix). Sera from vaccinated animals effectively prevent HPV pseudovirions to infect cell lines and mouse cervical epithelia...
June 8, 2016: Vaccine
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