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https://www.readbyqxmd.com/read/29776349/randomised-controlled-trial-rct-of-cannabinoid-replacement-therapy-nabiximols-for-the-management-of-treatment-resistant-cannabis-dependent-patients-a-study-protocol
#1
Anjali K Bhardwaj, David J Allsop, Jan Copeland, Iain S McGregor, Adrian Dunlop, Marian Shanahan, Raimondo Bruno, Nghi Phung, Mark Montebello, Craig Sadler, Jessica Gugusheff, Melissa Jackson, Jennifer Luksza, Nicholas Lintzeris
BACKGROUND: The cannabis extract nabiximols (Sativex®) effectively supresses withdrawal symptoms and cravings in treatment resistant cannabis dependent individuals, who have high relapse rates following conventional withdrawal treatments. This study examines the efficacy, safety and cost-effectiveness of longer-term nabiximols treatment for outpatient cannabis dependent patients who have not responded to previous conventional treatment approaches. METHODS/DESIGN: A phase III multi-site outpatient, randomised, double-blinded, placebo controlled parallel design, comparing a 12-week course of nabiximols to placebo, with follow up at 24 weeks after enrolment...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29773262/-smoking-cessation-pharmacological-strategies-different-from-standard-treatments
#2
REVIEW
M Underner, J Perriot, G Peiffer, G Harika-Germaneau, N Jaafari
INTRODUCTION: Three drugs are used as an aid for smoking cessation: nicotine replacement therapy (NRT), varenicline and bupropion. Standard pharmacological strategies have proven their efficacy but may have poor efficacy, especially among "Hard-core smokers" who display low smoking abstinence rates and high relapse rates. OBJECTIVES: Systematic literature review of data on pharmacological strategies for smoking cessation which are different from standard treatments...
May 14, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29766615/barriers-and-facilitators-to-smoking-cessation-in-pregnancy-and-in-the-post-partum-period-the-health-care-professionals-perspective
#3
Felix Naughton, Sarah Hopewell, Lesley Sinclair, Dorothy McCaughan, Jennifer McKell, Linda Bauld
OBJECTIVES: Health care professionals and the health care environment play a central role in protecting pregnant and post-partum women and their infants from smoking-related harms. This study aimed to better understand the health professional's perspective on how interactions between women, health care professionals, and the environment influence how smoking is managed. DESIGN: Semi-structured interviews and focus groups. METHODS: Data were from 48 health care staff involved in antenatal or post-partum care at two UK sites, including midwives, obstetricians, health visitors, GPs, pharmacists, service commissioners, and Stop Smoking Service (SSS) advisors and managers...
May 15, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29751076/tobacco-specific-nitrosamines-a-literature-review
#4
Evangelia Konstantinou, Foteini Fotopoulou, Athanasios Drosos, Nektaria Dimakopoulou, Zoi Zagoriti, Athanasios Niarchos, Dimitra Makrynioti, Dimitrios Kouretas, George Lagoumintzis, Konstantinos Poulas
Cigarette smoke is a complex mixture of chemicals, including several tobacco-specific nitrosamines (TSNA). Most TSNA are formed in tobacco during the post-harvest period, while a number are produced when a cigarette is burned. Considerable evidence supports the role of TSNA important causative factors for cancers of the lung, pancreas, esophagus, and oral cavity in people who use tobacco products. Of the known TSNA, nicotine-derived nitrosamine ketone (NNK) and N-nitrosonornicotine (NNN) are the most carcinogenic...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29747516/impact-and-effectiveness-of-a-stand-alone-nrt-starter-kit-in-a-statewide-tobacco-cessation-program
#5
Amy N Kerr, Barbara A Schillo, Paula A Keller, Randi B Lachter, Rebecca K Lien, Heather G Zook
PURPOSE: To examine 2-week nicotine replacement therapy (NRT) starter kit quit outcomes and predictors and the impact of adding this new service on treatment reach. DESIGN: Observational study of a 1-year cohort of QUITPLAN Services enrollees using registration and utilization data and follow-up outcome survey data of a subset of enrollees who received NRT starter kits. SETTING: ClearWay Minnesota's QUITPLAN Services provides a quit line that is available to uninsured and underinsured Minnesotans and NRT starter kits (a free 2-week supply of patches, gum, or lozenges) that are available to all Minnesota tobacco users...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29746451/tobacco-cessation-interventions-and-smoke-free-policies-in-mental-health-and-substance-abuse-treatment-facilities-united-states-2016
#6
Kristy Marynak, Brenna VanFrank, Sonia Tetlow, Margaret Mahoney, Elyse Phillips, Ahmed Jamal Mbbs, Anna Schecter, Doug Tipperman, Stephen Babb
Persons with mental or substance use disorders or both are more than twice as likely to smoke cigarettes as persons without such disorders and are more likely to die from smoking-related illness than from their behavioral health conditions (1,2). However, many persons with behavioral health conditions want to and are able to quit smoking, although they might require more intensive treatment (2,3). Smoking cessation reduces smoking-related disease risk and could improve mental health and drug and alcohol recovery outcomes (1,3,4)...
May 11, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29746088/structure-activity-studies-reveal-the-molecular-basis-for-gabab-receptor-mediated-inhibition-of-high-voltage-activated-calcium-channels-by-%C3%AE-conotoxin-vc1-1
#7
Mahsa Sadeghi, Bodil B Carstens, Brid P Callaghan, James T Daniel, Han Shen Tae, Tracey O'Donnell, Joel Castro, Stuart M Brierley, David J Adams, David J Craik, Richard J Clark
α-Conotoxins are disulfide-bonded peptides from cone snail venoms and are characterized by their affinity for nicotinic acetylcholine receptors (nAChR). Several α-conotoxins with distinct selectivity for nAChR subtypes have been identified as potent analgesics in animal models of chronic pain. However, a number of α-conotoxins have been shown to inhibit N-type calcium channel currents in rodent dissociated dorsal root ganglion (DRG) neurons via activation of G protein-coupled GABAB receptors (GABABR). Therefore it is unclear whether activation of GABABR or inhibition of α9α10 nAChRs is the analgesic mechanism...
May 10, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29727588/disparities-in-hospital-smoking-cessation-treatment-by-immigrant-status
#8
Jenny Chen, Ellie Grossman, Alissa Link, Binhuan Wang, Scott Sherman
Despite the efficacy of nicotine replacement therapy (NRT) in promoting smoking cessation, no studies have been done to evaluate NRT prescribing rates among immigrants, a vulnerable minority population in the United States. The aim of this study is to explore for differences in NRT prescribing behavior by immigrant status. Participants were enrolled in a smoking cessation trial for hospitalized patients between July 2011 and April 2014 at two NYC hospitals. For this analysis, we used baseline data from patient surveys and electronic medical-record reviews to examine associations between immigrant status and prescription of NRT in-hospital and on discharge, as well as acceptance of NRT in-hospital...
May 4, 2018: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29723802/integrating-smoking-cessation-care-into-routine-service-delivery-in-a-medically-supervised-injecting-facility-an-acceptability-study
#9
Eliza Skelton, Flora Tzelepis, Anthony Shakeshaft, Ashleigh Guillaumier, William Wood, Marianne Jauncey, Allison M Salmon, Sam McCrabb, Kerrin Palazzi, Billie Bonevski
BACKGROUND: Among people who inject drugs (PWIDs) the prevalence of tobacco smoking exceeds 80%; making smoking cessation intervention a priority for this population. This study aims to examine staff and client perspectives from a supervised injecting facility regarding: i) whether an organizational change intervention increased rates of smoking cessation care delivery (pre- to post-intervention); and ii) acceptability of the intervention. METHODS: A pre-and-post intervention pilot study in a supervised injecting facility was conducted in Sydney, Australia between July 2014-December 2015...
April 5, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29718549/are-australian-smokers-with-mental-illness-receiving-adequate-smoking-cessation-and-harm-reduction-information
#10
Ratika Sharma-Kumar, Carla Meurk, Pauline Ford, Diana Beere, Coral Gartner
Provision of smoking cessation support in the form of advice and information is central to increasing quit rates, including among people with mental illness (MI), who have 3-5 times higher odds of smoking than those without MI. This study investigated the extent and perceived utility of quit smoking advice and information available to Australian smokers with MI through face-to-face, semi-structured, in-depth interviews with 29 current smokers with MI. Qualitative analysis identified four major sources of quit smoking advice and information: (i) mental health practitioners; (ii) Quitline; (iii) social networks; and (iv) Internet and media...
May 2, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29700882/a-qualitative-approach-exploring-the-experiences-of-smoking-and-quitting-attempts-in-type-1-diabetes
#11
Haya Abu Ghazaleh, Henrietta Mulnier, Maria Duaso
AIMS AND OBJECTIVES: To explore the experiences of smoking and quitting attempts in people with Type 1 Diabetes (T1D), including their perceptions of existing services for smoking cessation. BACKGROUND: In the UK, approximately a fifth of the population with T1D smoke and despite the adverse effects of smoking, these individuals continue with their smoking habits. There is limited information on the barriers and facilitators to quitting smoking in people with T1D...
April 27, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29696311/can-we-increase-smokers-adherence-to-nicotine-replacement-therapy-and-does-this-help-them-quit
#12
Tanya R Schlam, Jessica W Cook, Timothy B Baker, Todd Hayes-Birchler, Daniel M Bolt, Stevens S Smith, Michael C Fiore, Megan E Piper
OBJECTIVE: To examine the effects of five intervention components on smokers' adherence to combined nicotine patch and nicotine gum during a quit attempt and assess whether adherence is related to cessation. METHOD: Smokers interested in quitting (N = 513; 59% female; 87% White) received nicotine patch plus nicotine gum and participated in a 2x2x2x2x2 randomized factorial experiment (i.e., 32 treatment conditions) evaluating five intervention components: (1) medication adherence counseling versus none; (2) automated medication adherence calls versus none; (3) electronic medication monitoring with feedback and counseling versus e-monitoring alone; (4) 26 versus 8 weeks of nicotine patch plus nicotine gum; and (5) maintenance counseling versus none...
April 25, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29696216/effectiveness-of-intensive-smoking-reduction-counselling-plus-combination-nicotine-replacement-therapy-in-promoting-long-term-abstinence-in-patients-with-chronic-obstructive-pulmonary-disease-not-ready-to-quit-smoking-protocol-of-the-reduq-trial
#13
Petra Hagens, Marcel Pieterse, Paul van der Valk, Job van der Palen
Introduction: Limited tobacco dependence treatment resources exist for smoking COPD patients not ready to quit. Smoking reduction may be a viable treatment approach if it prompts quit attempts and subsequent abstinence. This article describes the protocol of the REDUQ (REDUce and Quit) study, which examines whether smoking reduction counselling plus combination nicotine replacement therapy (NRT) is (cost-)effective in achieving long-term abstinence in smoking COPD patients not ready to quit...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29694428/differences-in-vaping-topography-in-relation-to-adherence-to-exclusive-electronic-cigarette-use-in-veterans
#14
Andrea Guerrero-Cignarella, Landy V Luna Diaz, Kira Balestrini, Gregory Holt, Mehdi Mirsaeidi, Rafael Calderon-Candelario, Philip Whitney, Matthias Salathe, Michael A Campos
BACKGROUND: Understanding vaping patterns of electronic cigarette (EC) use is important to understand the real-life exposure to EC vapor. Long term information on vaping topography in relation to tobacco cigarette (TC) smoking cessation success has not been explored. METHODS: Observational non-blinded study where active TC smokers were asked to replace TC with EC over 4 weeks (replacement phase, RP) followed by exclusive EC use for an additional 12 weeks (maintenance phase, MP)...
2018: PloS One
https://www.readbyqxmd.com/read/29691198/direct-observation-of-medicaid-beneficiary-attempts-to-fill-prescriptions-for-nicotine-replacement-medications
#15
Kimber P Richter, Elena Shergina, Amanda Grodie, Justin K Massey, Edward F Ellerbeck, Amanda Applegate, Babalola Faseru
OBJECTIVES: Although many states have expanded Medicaid coverage of cessation medications, utilization remains low. Anecdotal reports suggest that beneficiaries are at times denied coverage of cessation medications at the pharmacy counter. We conducted an observational community-wide case study of Medicaid beneficiary attempts to fill over-the-counter nicotine replacement therapy at pharmacies. METHODS: We recruited tobacco-using beneficiaries from a Federally Qualified Health Center, whose providers wrote paper prescriptions for nicotine patches...
April 21, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29684418/a-comprehensive-examination-of-own-and-cross-price-elasticities-of-tobacco-and-nicotine-replacement-products-in-the-u-s
#16
Jidong Huang, Cezary Gwarnicki, Xin Xu, Ralph S Caraballo, Roy Wada, Frank J Chaloupka
While much is known about the demand for cigarettes, research on the demand for non-cigarette tobacco products and the cross-price impacts among those products is limited. This study aims to comprehensively examine the own- and cross-price elasticities of demand for tobacco and nicotine replacement products (NRPs) in the U.S. We analyzed market-level quarterly data on sales and prices of 15 different types of tobacco products and NRPs from 2007 to 2014, compiled from retail store scanner data. Fixed effects models with controls were used to estimate their own-price elasticities and cross-price elasticities between cigarettes and the other 14 products...
April 20, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29671928/electronic-cigarette-use-among-cancer-patients-reasons-for-use-beliefs-and-patient-provider-communication
#17
John B Correa, Karen O Brandon, Lauren R Meltzer, Hannah J Hoehn, Bárbara Piñeiro, Thomas H Brandon, Vani N Simmons
OBJECTIVE: Smoking tobacco cigarettes after a cancer diagnosis increases risk for several serious adverse outcomes. Thus, patients can significantly benefit from quitting smoking. Electronic cigarettes are an increasingly popular cessation method. Providers routinely ask about combustible cigarette use, yet little is known about use and communication surrounding e-cigarettes among cancer patients. This study aims to describe cancer patient patterns, beliefs, and communication with oncology providers about e-cigarette use...
April 19, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29664530/-clinical-practice-guidelines-for-smoking-cessation
#18
María Paz Corvalán B, Leonardo Véjar M, Claudia Bambs S, Juana Pavié G, Mónica Zagolin B, Jaime Cerda L
Considering that a high proportion of the Chilean general population smokes, the Chilean Society of Respiratory Diseases in collaboration with the Chilean Societies of Cardiology and, Endocrinology and Diabetes, formed an interdisciplinary group, who issued a set of recommendations for the treatment of the smoker, methodologically advised by experts. These interventions should be prioritized in high-risk groups. Methods The panel elaborated and graded the recommendations following the GRADE methodology. To assess the effect of each intervention, systematic reviews and randomized clinical trials were identified...
November 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29661542/helping-patients-with-esrd-and-earlier-stages-of-ckd-to-quit-smoking
#19
REVIEW
Perry Formanek, Elizabeth Salisbury-Afshar, Majid Afshar
Among the many adverse effects of tobacco exposure is the increased risk for progression of kidney disease. Individuals with chronic kidney disease (CKD), who already face increased cardiovascular event rates compared to the general population, are at even greater risk if they smoke. Despite these risks and the increased focus on smoking cessation in the general population in recent years, national guidelines have not specifically targeted individuals with CKD. There are similarly sparse data specific to individuals with CKD regarding the safety and efficacy of evidence-based smoking cessation modalities...
April 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29650283/-interventions-for-smoking-cessation-in-2018
#20
REVIEW
J Abdul-Kader, G Airagnes, S D'almeida, F Limosin, A-L Le Faou
Smoking cessation treatments have been proved effective to stop smoking. For pharmacological treatments, nicotine replacement therapies (NRT) as well as bupropion allow to increase 6 month-abstinence rates by more than 80% in comparison with placebo while varenicline prescription doubles success rates in the same conditions. These results mean that for 10 smokers who quit with placebo, 18 are expected to quit with NRT or bupropion and 28 are expected to quit with varenicline. Varenicline is 50% more effective than nicotine patch and 70% more effective than nicotine gum...
April 9, 2018: Revue de Pneumologie Clinique
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