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https://www.readbyqxmd.com/read/28922717/magnetic-nanoparticle-loaded-alginate-beads-for-local-micro-actuation-of-in-vitro-tissue-constructs
#1
Awatef M Alshehri, Otto C Wilson, Bishnu Dahal, John Philip, Xiaolong Luo, Christopher B Raub
Magnetic nanoparticles (MNPs) self-align and transduce magnetic force, two properties which lead to promising applications in cell and tissue engineering. However, the toxicity of MNPs to cells which uptake them is a major impediment to applications in engineered tissue constructs. To address this problem, MNPs were embedded in millimeter-scale alginate beads, coated with glutaraldehyde cross-linked chitosan, and loaded in acellular and MDA-MB-231 cancer cell-seeded collagen hydrogels, providing local micro-actuation under an external magnetic field...
September 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28922635/fucoidan-coated-ciprofloxacin-loaded-chitosan-nanoparticles-for-the-treatment-of-intracellular-and-biofilm-infections-of-salmonella
#2
Elbi S, Nimal T R, Rajan V K, Gaurav Baranwal, Raja Biswas, Jayakumar R, Sathianarayanan S
Salmonella infections and their gallstone associated biofilm infections are difficult to treat due to poor penetration of antibiotics into the intracellular compartments of macrophages and within biofilms. Here we developed ciprofloxacin loaded chitosan nanoparticles (cCNPs) and fucoidan (Fu) coated cCNPs (Fu-cCNPs). Characterizations of these nanoparticles were carried out using Dynamic Light Scattering‎, Transmission electron microscopy and Fourier transform infrared spectroscopy. The prepared cCNPs and Fu-cCNPs have the size range of 124±7nm and 320±18nm, respectively...
September 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28922603/semiconductor-plasmon-induced-upconversion-enhancement-in-mcu2-xs-sio2-y2o3-yb-3-er-3-core-shell-nanocomposites
#3
Donglei Zhou, Dongyu Li, Xiangyu Zhou, Wen Xu, Xu Chen, Dali Liu, Yongsheng Zhu, Hongwei Song
The ability to modulate the intensity of electromagnetic field by semiconductor plasmon nanoparticles is becoming attractive owing to its unique doping induced local surface plasmon resonance (LSPR) effect different from metals. Herein, we synthesized the mCu2-xS@SiO2@Y2O3:Yb(3+),Er(3+) core-shell composites and experimentally and theoretically studied the semiconductor plasmon induced upconversion (UC) enhancement, and obtained 30 folds UC enhancement compared to that of SiO2@Y2O3:Yb(3+),Er(3+) composites...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28922597/core-shell-silver-nanoparticles-in-endodontic-disinfection-solutions-enable-long-term-antimicrobial-effect-on-oral-biofilms
#4
Elif Ertem Bekdemir, Beatrice Gutt, Flavia Zuber, Sergio Allegri, Benjamin Le Ouay, Selma Mefti, Kitty Formentin, Francesco Stellacci, Qun Ren
To achieve effective long-term disinfection of the root canals, we synthesized core-shell silver nanoparticles (AgNPs@SiO2) and used them to develop two irrigation solutions containing sodium phytate (SP) and ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), respectively. Ex vivo studies with instrumented root canals revealed that the developed irrigation solutions can effectively remove the smear layer from the dentinal surfaces. Further in vitro experiments with single and multi-species biofilms demonstrated for the first time that AgNPs@SiO2 based irrigation solutions possess excellent antimicrobial activities for at least 7 days, whereas the bare AgNPs lose the activity almost immediately and do not show any antibacterial activity after 2 days...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28922574/super-resolution-microscopy-unveils-dynamic-heterogeneities-in-nanoparticle-protein-corona
#5
Natalia Feiner-Gracia, Michaela Beck, Sílvia Pujals, Sébastien Tosi, Tamoghna Mandal, Christian Buske, Mika Linden, Lorenzo Albertazzi
The adsorption of serum proteins, leading to the formation of a biomolecular corona, is a key determinant of the biological identity of nanoparticles in vivo. Therefore, gaining knowledge on the formation, composition, and temporal evolution of the corona is of utmost importance for the development of nanoparticle-based therapies. Here, it is shown that the use of super-resolution optical microscopy enables the imaging of the protein corona on mesoporous silica nanoparticles with single protein sensitivity...
September 18, 2017: Small
https://www.readbyqxmd.com/read/28922572/s-doped-tise2-nanoplates-fe3-o4-nanoparticles-heterostructure
#6
Jun Yang, Yufei Zhang, Yizhou Zhang, Jinjun Shao, Hongbo Geng, Yu Zhang, Yun Zheng, Mani Ulaganathan, Zhengfei Dai, Bing Li, Yun Zong, Xiaochen Dong, Qingyu Yan, Wei Huang
2D Sulfur-doped TiSe2 /Fe3 O4 (named as S-TiSe2 /Fe3 O4 ) heterostructures are synthesized successfully based on a facile oil phase process. The Fe3 O4 nanoparticles, with an average size of 8 nm, grow uniformly on the surface of S-doped TiSe2 (named as S-TiSe2 ) nanoplates (300 nm in diameter and 15 nm in thickness). These heterostructures combine the advantages of both S-TiSe2 with good electrical conductivity and Fe3 O4 with high theoretical Li storage capacity. As demonstrated potential applications for energy storage, the S-TiSe2 /Fe3 O4 heterostructures possess high reversible capacities (707...
September 18, 2017: Small
https://www.readbyqxmd.com/read/28922553/programmable-nucleic-acid-based-polygons-with-controlled-neuroimmunomodulatory-properties-for-predictive-qsar-modeling
#7
Morgan Brittany Johnson, Justin R Halman, Emily Satterwhite, Alexey V Zakharov, My N Bui, Kheiria Benkato, Victoria Goldsworthy, Taejin Kim, Enping Hong, Marina A Dobrovolskaia, Emil F Khisamutdinov, Ian Marriott, Kirill A Afonin
In the past few years, the study of therapeutic RNA nanotechnology has expanded tremendously to encompass a large group of interdisciplinary sciences. It is now evident that rationally designed programmable RNA nanostructures offer unique advantages in addressing contemporary therapeutic challenges such as distinguishing target cell types and ameliorating disease. However, to maximize the therapeutic benefit of these nanostructures, it is essential to understand the immunostimulatory aptitude of such tools and identify potential complications...
September 18, 2017: Small
https://www.readbyqxmd.com/read/28922528/mass-production-and-pore-size-control-of-holey-carbon-microcages
#8
Lei Zhang, Xiaoxiao Liu, Yuhai Dou, Binwei Zhang, Huiling Yang, Shixue Dou, Huakun Liu, Yunhui Huang, Xianluo Hu
Architectural control of porous solids, such as porous carbon cages, has received considerable attention for versatile applications because of their attractive ability to interact with liquids and gases not only at the surface, but throughout the bulk. Here we report a scalable, facile spray-pyrolysis route to synthesize holey carbon microcages with mosquito-net-like shells. Using the surfaces of water droplets as the growth templates, styrene-butadiene rubber macromolecules are controllably cross-linked, and size-tunable holes on the carbon shells are generated...
September 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28922508/single-oxidative-collision-events-of-silver-nanoparticles-understanding-the-rate-determining-chemistry
#9
Kamonwad Ngamchuea, Richard O D Clark, Stanislav V Sokolov, Neil P Young, Christopher Batchelor-McAuley, Richard G Compton
The oxidative dissolution of citrate-capped silver nanoparticles (AgNPs) is investigated herein by two electrochemical techniques: nano-impacts and anodic stripping voltammetry. Nano-impacts or single nanoparticle-electrode collisions allow the detection of individual nanoparticles. The technique offers an advantage over surface-immobilized methods such as anodic stripping voltammetry as it eliminates the effects of particle agglomeration/ aggregation. The electrochemical studies are performed in different electrolytes (KNO3, KCl, KBr and KI) at varied concentrations ( 20 mM)...
September 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28922494/magnetic-nanotransducers-in-biomedicine
#10
Agostina Grillone, Gianni Ciofani
Owing to their abilities to identify diseased conditions, to modulate biological process, and to control cellular activities, magnetic nanoparticles have become one of the most popular nanomaterials exploited in the biomedical field. Targeted drug delivery, controlled drug release, hyperthermia treatments, imaging, and stimulation of several biological entities are just some of the several tasks that can be accomplished by taking advantage of magnetic nanoparticles in tandem with magnetic fields. The huge interest towards this class of nanomaterials rises from the possibility to physically drive their spatiotemporal localization inside the body, and to deliver an externally applied stimulation at a target site...
September 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28922482/bottom-up-single-electron-transistors
#11
Ksenia S Makarenko, Zhihua Liu, Michel P de Jong, Floris A Zwanenburg, Jurriaan Huskens, Wilfred G van der Wiel
As the downscaling of conventional semiconductor electronics becomes more and more challenging, the interest in alternative material systems and fabrication methods is growing. A novel bottom-up approach for the fabrication of high-quality single-electron transistors (SETs) that can easily be contacted electrically in a controllable manner is developed. This approach employs the self-assembly of Au nanoparticles forming the SETs, and Au nanorods forming the leads to macroscopic electrodes, thus bridging the gap between the nano- and microscale...
September 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28922476/semiconducting-polymer-nanoparticles-for-centimeters-deep-photoacoustic-imaging-in-the-second-near-infrared-window
#12
Jiayingzi Wu, Liyan You, Lu Lan, Hyeon Jeong Lee, Saadia T Chaudhry, Rui Li, Ji-Xin Cheng, Jianguo Mei
Thienoisoindigo-based semiconducting polymer with a strong near-infrared absorbance is synthesized and its water-dispersed nanoparticles (TSPNs) are investigated as a contrast agent for photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1350 nm). The TSPNs generate a strong PA signal in the NIR-II optical window, where background signals from endogenous contrast agents, including blood and lipid, are at the local minima. By embedding a TSPN-containing tube in chicken-breast tissue, an imaging depth of more than 5 cm at 1064 nm excitation is achieved with a contrast-agent concentration as low as 40 µg mL(-1) ...
September 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28922358/quantifying-the-effects-of-antiangiogenic-and-chemotherapy-drug-combinations-on-drug-delivery-and-treatment-efficacy
#13
Sirin Yonucu, Defne Yιlmaz, Colin Phipps, Mehmet Burcin Unlu, Mohammad Kohandel
Tumor-induced angiogenesis leads to the development of leaky tumor vessels devoid of structural and morphological integrity. Due to angiogenesis, elevated interstitial fluid pressure (IFP) and low blood perfusion emerge as common properties of the tumor microenvironment that act as barriers for drug delivery. In order to overcome these barriers, normalization of vasculature is considered to be a viable option. However, insight is needed into the phenomenon of normalization and in which conditions it can realize its promise...
September 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28922111/optimization-of-the-working-conditions-for-magnetic-nanoparticle-enhanced-microwave-diagnostics-of-breast-cancer
#14
Gennaro Bellizzi, Gennaro G Bellizzi, Ovidio M Bucci, Lorenzo Crocco, Marko Helbig, Sebastian Ley, Juergen Sachs
Magnetic nanoparticle-aided microwave imaging is recently gaining an increasing interest as potential tool for breast cancer diagnostics. This is due to the peculiar features of magnetic nanoparticles, which are biocompatible, can be selectively targeted to the tumor and may change their microwave magnetic response when modulated by a polarizing magnetic field. This latter aspect is particularly appealing, as it enables the physical separation of the microwave signal due the malignancy, targeted by the nanoparticles, from that due to healthy tissue...
September 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28921953/new-antimony-selenide-nickel-oxide-photocathode-boosts-the-efficiency-of-graphene-quantum-dots-co-sensitized-solar-cell
#15
Ankita Kolay, Ramesh K Kokal, Ankarao Kalluri, Isaac Macwan, Prabir K Patra, Partha Ghosal, Melepurath Deepa
A novel assembly of a photocathode and photoanode is investigated to explore their complementary effects in enhancing the photovoltaic performance of a quantum dot solar cell (QDSC). While p-type nickel oxide (NiO) has been used previously, antimony selenide (Sb2Se3) has not been used in a QDSC, especially as a component of a counter electrode (CE) architecture that doubles up as the photocathode. Here, near infrared (NIR) light absorbing Sb2Se3 nanoparticles (NPs) coated over electrodeposited NiO nanofibers on a carbon (C)-fabric substrate was employed as the highly efficient photocathode...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921952/nano-air-seeds-trapped-in-mesoporous-janus-nanoparticles-facilitate-cavitation-and-enhance-ultrasound-imaging
#16
Konstantin Tamarov, Andrey Sviridov, Wujun Xu, Markus Malo, Valery Andreev, Victor Yu Timoshenko, Vesa-Pekka Lehto
The current contrast agents utilized in ultrasound (US) imaging are based on microbubbles which, however, suffer from a short lifetime in the systemic circulation. The present study introduces a new type of contrast agents for US imaging based on bioresorbable Janus nanoparticles (NPs) that are able to generate microbubbles in situ under US radiation for extended time. The Janus NPs were fabricated from porous silicon (PSi) that was modified via a nanostopper technique. The technique was exploited to prepare PSi NPs which had hydrophobic pore walls (inner face) while the external surfaces of the NPs (outer face) were hydrophilic...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921950/highly-efficient-and-rapid-neural-differentiation-of-mouse-embryonic-stem-cells-based-on-retinoic-acid-encapsulated-porous-nanoparticle
#17
Se-Jin Park, Seongchan Kim, Sung-Yon Kim, Noo Li Jeon, Joon Myong Song, Cheolhee Won, Dal-Hee Min
An improved cell conversion strategy for neural differentiation of mouse embryonic stem (mES) cells is developed by incorporating functionalized mesoporous silica nanoparticle (MSN) as an efficient delivery carrier of retinoic acid (RA), which is pleiotropic factor required for initiation of neural differentiation. Traditional RA-mediated neural differentiation methods required either pre-activation of the cells to the differentiating state by embryoid body (EB) formation or repetitive treatment of the differentiation factor...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921902/mechanistic-parameters-of-electrocatalytic-water-oxidation-on-limn2o4-in-comparison-to-natural-photosynthesis
#18
Lennart Köhler, Majid Ebrahimizadeh Abrishami, Vladimir Roddatis, Janis Geppert, Marcel Risch
Targeted improvement of the low efficiency of water oxidation during the oxygen evolution reaction (OER) is severely hindered by insufficient knowledge of the electrocatalytic mechanism on heterogeneous surfaces. We chose LiMn2O4 as a model system for mechanistic investigations as it shares the cubane structure with the active site of photosystem II and the valence of Mn3.5+ with the dark-stable S1 state in the mechanism of natural photosynthesis. The investigated LiMn2O4 nanoparticles are electrochemically stable in NaOH electrolytes and show respectable activity in any of the main metrics...
September 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28921705/green-tea-makes-polyphenol-nanoparticles-with-radical-scavenging-activities
#19
Siying Xiang, Peng Yang, Hao Guo, Shu Zhang, Xiaokang Zhang, Fang Zhu, Yiwen Li
The constant demand for functional nanomaterials from natural biomass polymers usually requires new "green" synthetic strategies without using any foreign additives. Here, the green fabrication of a series of polyphenol nanoparticles (PNs) only from green tea extraction compounds is reported (i.e., tea polyphenols and theophylline). It is found that the nanoparticle formation process involves covalent copolymerization of monomers, as well as noncovalent self-assembly pathways. Additionally, the resulting PNs exhibit better free-radical scavenging activities compared with similar-sized, polydopamine-based synthetic melanin nanoparticles...
September 15, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28921444/polyester-based-nanoparticles-for-delivery-of-therapeutic-proteins
#20
Pedro Fonte, Flávia Sousa, Bruno Sarmento
Therapeutic proteins are widely used to treat severe conditions, such as oncologic and metabolic diseases, and also for vaccination. They are recognized for its high biopotency, but their hydrophilicity and high molecular weight make its transport through membranes difficult to achieve. They may also suffer in vivo structural instability caused by a proteolytic cleavage, turning them biological inactive. Polyester-based nanoparticles are useful tools to overcome such problems, and deliver therapeutic proteins in a controlled and localized manner, decreasing the number of administrations needed and enhancing the therapeutic outcome...
2018: Methods in Molecular Biology
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