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Diabetes, cardiovascular, testosterone, sex steroids, alcohol, smoking

Kathryn M Rexrode, JoAnn E Manson, I-Min Lee, Paul M Ridker, Patrick M Sluss, Nancy R Cook, Julie E Buring
BACKGROUND: Despite diffuse effects of sex hormones on the cardiovascular system, few prospective studies have examined the relationship of plasma androgens and estrogens with risk of cardiovascular disease (CVD) in postmenopausal women. METHODS AND RESULTS: A nested case-control study was performed among women in the Women's Health Study. Two hundred women who developed CVD were matched 1:1 by age, smoking, and postmenopausal hormone therapy (HT) to controls who remained free of CVD...
October 7, 2003: Circulation
S M Haffner, R A Valdez, M P Stern, M S Katz
An unfavourable body fat distribution may cause metabolic abnormalities including diabetes and dyslipidemia. These effects may be mediated by alterations in sex hormones. In women the available data suggest that upper body adiposity is related to increased androgenicity (especially as indicated by low concentrations of sex hormone binding globulin). Few data, however, are available on these relationships in men. We therefore examined the association of total testosterone, free testosterone, oestradiol, dehydroepiandrosterone sulphate (DHEA-SO4) and sex hormone binding globulin (SHBG) to waist-to-hip ratio (WHR) and conicity index in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease...
November 1993: International Journal of Obesity and related Metabolic Disorders
M Pugeat, P Moulin, P Cousin, S Fimbel, M H Nicolas, J C Crave, H Lejeune
The incidence of coronary artery disease is significantly higher in men than in women, at least until menopause. This gender difference could be explained by the action of sex steroids on the lipoprotein profile. In prepubertal children, high-density lipoprotein (HDL) cholesterol and triglyceride levels are similar between sexes, while adult men have generally lower HDL cholesterol and higher triglyceride levels than premenopausal adult women. Most cross-sectional studies have reported that sex hormone binding globulin (SHBG) and testosterone levels correlate positively with HDL cholesterol levels between sexes...
June 1995: Journal of Steroid Biochemistry and Molecular Biology
P Björntorp
Ageing is followed by an involution of neuroendocrine functions, resulting in a decreased secretion of sex steroids and growth hormone. In addition, cortisol secretion may be inadequately elevated upon stress challenges, due to deficient braking functions by central glucocorticoid receptors. In combination, these endocrine perturbations will probably result in changes in psychological factors such as energy and well-being, altered body composition, and insulin resistance, as well as other risk factors for diseases characteristic of the ageing human, such as cardiovascular disease, non-insulin-dependent diabetes mellitus and stroke...
November 1995: Journal of Internal Medicine
P Björntorp
Recent studies have shown the predictive power of abdominal distribution of adipose tissue for the development of cardiovascular disease, stroke, diabetes as well as strong associations to the previously known risk factors for these endpoints. The reason for the accumulation of abdominal fat might be due to an imbalance between cortisol and sex steroid hormones. Cortisol receptor density seems to be particularly high in abdominal adipose tissue, leading to expression of lipoprotein lipase activity primarily here...
February 1990: Infusionstherapie
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