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https://www.readbyqxmd.com/read/29475160/immunotoxicity-of-ochratoxin-a-and-aflatoxin-b1-in-combination-is-associated-with-the-nuclear-factor-kappa-b-signaling-pathway-in-3d4-21-cells
#1
Lili Hou, Fang Gan, Xuan Zhou, Yajiao Zhou, Gang Qian, Zixuan Liu, Kehe Huang
The co-contamination of cereals, grains, crops, and animal feeds by mycotoxins is a universal problem. Humans and animals are exposed to several mycotoxins simultaneously as evidenced by extensive studies on this topic. Yet, most studies have addressed the effects of mycotoxins individually. Aflatoxin B1 and ochratoxin A can induce immunotoxicity. However, it remains unclear whether a combination of these mycotoxins aggravates immunotoxicity and the potential mechanism underlying this effect. In this study, we used the cell line 3D4/21, swine alveolus macrophages and innate immune cell...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29475134/inhibition-of-phosphodiesterase-4-by-fcpr16-protects-sh-sy5y-cells-against-mpp-induced-decline-of-mitochondrial-membrane-potential-and-oxidative-stress
#2
Jiahong Zhong, Hui Yu, Chang Huang, Qiuping Zhong, Yaping Chen, Jinfeng Xie, Zhongzhen Zhou, Jiangping Xu, Haitao Wang
Phosphodiesterase 4 (PDE4) is a promising target for the treatment of Parkinson's disease (PD). However, the underlying mechanism has not yet been well elucidated. Additionally, most of current PDE4 inhibitors produce severe nausea and vomiting response in patients, which limit their clinical application. FCPR16 is a novel PDE4 inhibitor with little emetic potential. In the present study, the neuroprotective effect and underlying mechanism of FCPR16 against cellular apoptosis induced by 1-methyl-4-phenylpyridinium (MPP+ ) were examined in SH-SY5Y cells...
February 14, 2018: Redox Biology
https://www.readbyqxmd.com/read/29475133/reactive-oxygen-species-promote-tubular-injury-in-diabetic-nephropathy-the-role-of-the-mitochondrial-ros-txnip-nlrp3-biological-axis
#3
Yachun Han, Xiaoxuan Xu, Chengyuan Tang, Peng Gao, Xianghui Chen, Xiaofen Xiong, Ming Yang, Shikun Yang, Xuejing Zhu, Shuguang Yuan, Fuyou Liu, Li Xiao, Yashpal S Kanwar, Lin Sun
NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of patients with diabetic nephropathy (DN) is unclear. Here, we demonstrated that mtROS overproduction is accompanied by decreases in TRX expression and TXNIP up-regulation. In addition, we discovered that mtROS overproduction is also associated with increases in NLRP3/IL-1β and TGF-β expression in the kidneys of patients with DN and db/db mice...
February 15, 2018: Redox Biology
https://www.readbyqxmd.com/read/29475125/reactive-oxygen-species-initiate-a-protective-response-in-plant-roots-to-stress-induced-by-environmental-bisphenol-a
#4
Jiazhi Zhang, Lihong Wang, Qing Zhou, Xiaohua Huang
Bisphenol A (BPA), a contaminant of emerging concern, can affect plant growth and development at high concentrations. Reactive oxygen species (ROS) production is a general primary response in plants to stress. Here, the aim is to investigate whether ROS in plants play protective roles for stress induced by BPA exposure at environmental concentrations. In this study, soybean roots (seedling, flowering and podding stages) were exposed to 1.5 and 3.0 mg L-1 BPA, and ROS response was measured. The relationship between ROS levels and residual BPA content in soybean roots was evaluated...
February 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29475072/digital-gene-expression-profiling-reveals-transcriptional-responses-to-acute-cold-stress-in-chinese-soft-shelled-turtle-pelodiscus-sinensis-juveniles
#5
Wen-Yi Zhang, Cui-Juan Niu, Bo-Jian Chen, Kenneth B Storey
Turtles are well known for their stress tolerance, including an ability to deal with temperature extremes or rapid thermal change. To know more about the comprehensive molecular basis of thermal stress responses in turtles, we assessed differentially expressed genes (DEGs) in the brain, liver and kidney of juvenile soft-shelled turtles, Pelodiscus sinensis, after acute cold stress (28 °C-8 °C acute transfer and held for 12 h) and following recovery (back to 28 °C and held for 24 h) by digital gene expression profiling...
February 20, 2018: Cryobiology
https://www.readbyqxmd.com/read/29475069/in-vitro-model-to-study-cocaine-and-its-contaminants
#6
Aline Steinmetz, Luiza Steffens, Ana Moira Morás, Flávia Prezzi, Elizandra Braganhol, Jenifer Saffi, Rafael Scorsatto Ortiz, Helena M T Barros, Dinara Jaqueline Moura
Cocaine is one of the most popular illicit drug worldwide. Due its great addictive potential, which leads to euphoria and hyperactivity, it is considered a public health concern. At the central nervous system, the drug acts inhibiting catecholamine re-uptake. It is now known that in addition to the toxicity of the drug itself, the contaminants present in the street drug have raised concern about the harmful effects on health. Toxicological in vivo and in vitro studies have demonstrated the toxic effects of cocaine correlated with the generation of reactive oxygen species (ROS), which in turn lead to oxidative damage to the cells...
February 20, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29475060/lanatoside-c-inhibits-cell-proliferation-and-induces-apoptosis-through-attenuating-wnt-%C3%AE-catenin-c-myc-signaling-pathway-in-human-gastric-cancer-cell
#7
Yudong Hu, Kaikai Yu, Gang Wang, Depeng Zhang, Chaoji Shi, Yunhe Ding, Duo Hong, Dan Zhang, Huiqiong He, Lei Sun, Jun-Nian Zheng, Shuyang Sun, Feng Qian
Gastric cancer is the third common cause of cancer mortality in the world with poor prognosis and high recurrence due to lack of effective medicines. Our studies revealed that lanatoside C, a FDA-approved cardiac glycoside, had an anti-proliferation effect on different human cancer cell lines (MKN-45; SGC-7901; HN4; MCF-7; HepG2) and gastric cell lines MKN-45 and SGC-7901 were the most sensitive cell lines to lanatoside C. MKN-45 cells treated with lanatoside C showed cell cycle arrest at G2/M phase and inhibition of cell migration...
February 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29475033/morphophysiological-and-transcriptome-analysis-reveals-a-multiline-defense-system-enabling-cyanobacterium-leptolyngbya-strain-jsc-1-to-withstand-iron-induced-oxidative-stress
#8
Sikandar Khan, Jing Lv, Arshad Iqbal, Pengcheng Fu
Iron intoxications induce severe oxidative stress by producing reactive oxygen species (ROS) in cyanobacteria, leading to membrane lipid peroxidation, altered morphology, impaired photosynthesis and other oxidative stress injuries. Given these stresses, mitigation of ROS is a prerequisite for all aerobic organisms. Study of siderophilic cyanobacterium Leptolyngbya strain JSC-1 inhabiting iron-rich hot springs may provide insight into the mechanism of iron homeostasis and alleviation of oxidative stress. In this study, we investigated the morphophysiological and molecular mechanisms enabling this cyanobacterium to cope with iron-induced oxidative stress...
February 19, 2018: Chemosphere
https://www.readbyqxmd.com/read/29474964/hypoxia-specific-therapeutic-agents-delivery-nanotheranostics-a-sequential-strategy-for-ultrasound-mediated-on-demand-tritherapies-and-imaging-of-cancer
#9
Qianhua Feng, Yuzhen Li, Xuemei Yang, Wanxia Zhang, Yongwei Hao, Hongling Zhang, Lin Hou, Zhenzhong Zhang
The hypoxic microenvironment induced by sonodynamic therapy (SDT) via sonochemical oxygen consumption usually triggered tumor resistance to SDT, impeding therapeutic efficacy. In this sense, it was highly desired to tackle the hypoxia-related negative issues. Here we provide the therapeutic agents delivery system, TPZ/HMTNPs-SNO, which was constructed by loading tirapazamine (TPZ) into hollow mesoporous titanium dioxide nanoparticles (HMTNPs) with modification of S-nitrosothiol (R-SNO). Upon encountering ultrasound waves, the HMTNPs as sonosensitizers would generate reactive oxygen species (ROS) for SDT...
February 20, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29474837/mitochondrial-accumulation-of-doxorubicin-in-cardiac-and-diaphragm-muscle-following-exercise-preconditioning
#10
Aaron B Morton, Andres Mor, J Matthew Hinkley, Noriko Ichinoseki-Sekine, Demetra D Christou, Ashley J Smuder
Doxorubicin (DOX) is a highly effective anthracycline antibiotic. Unfortunately, the clinical use of DOX is limited by the risk of deleterious effects to cardiac and respiratory (i.e. diaphragm) muscle, resulting from mitochondrial reactive oxygen species (ROS) production. In this regard, exercise is demonstrated to protect against DOX-induced myotoxicity and prevent mitochondrial dysfunction. However, the protective mechanisms are currently unclear. We hypothesized that exercise may induce protection by increasing the expression of mitochondria-specific ATP-binding cassette (ABC) transporters and reducing mitochondrial DOX accumulation...
February 20, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29474667/the-transcription-factor-csbhlh18-of-sweet-orange-citrus-sinensis-functions-in-modulation-of-cold-tolerance-and-reactive-oxygen-species-homeostasis-by-regulating-the-antioxidant-gene
#11
Jingjing Geng, Ji-Hong Liu
The basic helix-loop-helix (bHLH) transcription factors (TFs) comprise one of the largest gene families in plants and participate in various physiological processes, but physiological role and regulatory function of the majority of bHLHs remain poorly understood. Here, a total of 56 putative CsbHLH genes were identified in sweet orange (Citrus sinensis) based on a genome-wide analysis. The CsbHLHs, except four members, were distributed throughout nine chromosomes and divided into 19 subgroups. Most of the CsbHLH genes were responsive to cold stress, with the greatest upregulation being observed in CsbHLH18...
February 21, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29474658/tio2-nps-alleviates-high-temperature-induced-oxidative-stress-in-silkworms
#12
Jinxin Li, Bin Xue, Xiaoyu Cheng, Jiahuan Hu, Jinsheng Hu, Jianghai Tian, Fanchi Li, Xiaohua Yu, Bing Li
Silkworm, Bombyx mori (L.; Lepidoptera: Bombycidae), is an economically important insect, which is sensitive to the environment and susceptible to oxidative damages at high temperature. Low concentrations of TiO2 NPs (titanium dioxide nanoparticles) can scavenge reactive oxygen species (ROS) produced by oxidative damages in vivo. To explore whether TiO2 NPs could alleviate oxidative damages of high temperature, the effects of TiO2 NPs treatment on silkworm growth, the levels of ROS and H2O2, as well as the transcription level of antioxidant-related genes were studied at 30°C...
February 21, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29474405/phenyl-sulfate-indoxyl-sulfate-and-p-cresyl-sulfate-decrease-glutathione-level-to-render-cells-vulnerable-to-oxidative-stress-in-renal-tubular-cells
#13
Takeo Edamatsu, Ayako Fujieda, Yoshiharu Itoh
In chronic kidney disease patients, oxidative stress is generally associated with disease progression and pathogenesis of its comorbidities. Phenyl sulfate is a protein-bound uremic solute, which accumulates in chronic kidney disease patients, but little is known about its nature. Although many reports revealed that protein-bound uremic solutes induce reactive oxygen species production, the effects of these solutes on anti-oxidant level have not been well studied. Therefore, we examined the effects of protein-bound uremic solutes on glutathione levels...
2018: PloS One
https://www.readbyqxmd.com/read/29474366/cr6-interacting-factor-1-deficiency-promotes-endothelial-inflammation-by-sirt1-downregulation
#14
Shuyu Piao, Jun Wan Lee, Harsha Nagar, Saet-Byel Jung, Sujeong Choi, Seonhee Kim, Ikjun Lee, Sung-Min Kim, Nara Shin, Yu Ran Lee, Sang Do Lee, Jin Bong Park, Kaikobad Irani, Minho Won, Gang Min Hur, Byeong Hwa Jeon, Dong Woon Kim, Cuk-Seong Kim
AIMS: CR6 interacting factor 1 (CRIF1) deficiency impairs mitochondrial oxidative phosphorylation complexes, contributing to increased mitochondrial and cellular reactive oxygen species (ROS) production. CRIF1 downregulation has also been revealed to decrease sirtuin 1 (SIRT1) expression and impair vascular function. Inhibition of SIRT1 disturbs oxidative energy metabolism and stimulates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-induced inflammation. Therefore, we hypothesized that both CRIF1 deficiency-induced mitochondrial ROS production and SIRT1 reduction play stimulatory roles in vascular inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29474123/neuroprotective-effects-of-the-methanol-extract-of-kimchi-a-korean-fermented-vegetable-food-mediated-via-suppression-of-endoplasmic-reticulum-stress-and-caspase-cascade-pathways-in-high-cholesterol-diet-fed-mice
#15
Serim Kim, Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
Endoplasmic reticulum (ER) stress-related unfolded peptide accumulation is closely associated with the development of neurodegenerative diseases known as protein misfolding disorders. The antioxidative properties of kimchi, a traditional Korean fermented vegetable dish, have been well established. In this study, the neuroprotective effects of the kimchi methanol extract (KME) were examined in high-cholesterol diet (HCD)-fed mice. The animals were fed a HCD, with oral administration of either KME (KME group, 200 mg·kg bw-1 ·day-1 , n = 10) or distilled water (Control group, n = 10) for 8 weeks...
February 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29473989/bacillus-amyloliquefaciens-alters-gene-expression-ros-production-and-lignin-synthesis-in-cotton-seedling-roots
#16
Ivelisse Irizarry, James F White
AIMS: Previous research demonstrated that applying Bacillus amyloliquefaciens to cotton seeds promotes growth, alters root architecture, and alleviates salt stress of cotton seedlings. This research was undertaken to further study the genetic responses elicited in cotton seedlings by this growth promoting bacterium. METHODS AND RESULTS: GeneChip microarrays and RT-qPCR were used to detect changes in gene expression in seedling roots inoculated with B. amyloliquefaciens...
February 23, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29473842/antioxidant-activity-and-protective-effects-of-enzyme-extracted-oudemansiella-radiata-polysaccharides-on-alcohol-induced-liver-injury
#17
Xiuxiu Wang, Min Liu, Chen Zhang, Shangshang Li, Qihang Yang, Jianjun Zhang, Zhiyuan Gong, Jiandong Han, Le Jia
This work was to examine the antioxidation in vitro and hepatoprotective effects of enzyme-extracted Oudemansiella radiata polysaccharides (En-OPS) on alcohol-induced liver damage in mice. The antioxidant activities were determined according to the scavenging effects of En-OPS on hydroxyl, superoxide, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, and the level of reducing power. En-OPS showed hepatoprotective activities on decreasing the serum levels of aspertate aminotransferase (AST), alamine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as hepatic lipid levels of total cholesterol (TC) and triacylglycerols (TG)...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29473535/an-overview-on-hepatoprotective-effects-of-thymoquinone
#18
Tahereh Farkhondeh, Mohammad-Foad Noorbakhsh, Farzad Hayati, Saeed Samarghandian, Hanieh Shaterzadeh-Yazdi
Liver as an essential organ has an important function in metabolism and waste secretion from the body. Disorders of this organ may caused by several reasons such as high alcoholic consumption, various chemical or microbial agents and various hepatic cancers. Reactive and oxidative stress and oxygen species (ROS) are introduced the main mechanisms of these hepatic injuries. The seeds of Nigella sativa (Family Ranunculaceae) which is known as black seed, is widely used as a medicinal herb for cure or prevention of many of diseases such as liver problems...
February 20, 2018: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/29473408/adaptation-of-operational-parameters-of-cold-atmospheric-plasma-for-in-vitro-treatment-of-cancer-cells
#19
Eda Gjika, Sonali Pal-Ghosh, Anna Tang, Megan Kirschner, Gauri Tadvalkar, Jerome Canady, Mary Ann Stepp, Michael Keidar
Cold atmospheric plasma (CAP), an ionized gas operated at near ambient temperature has been introduced as a new therapeutic opportunity for treating cancers. The effectiveness of the therapy has been linked to CAP generated reactive oxygen and nitrogen species such as hydrogen peroxide and nitrite. In this study, we monitor in real time cancer cell response to CAP over the course of 48 hours. The results demonstrate a correlation between cell viability, exposure time (30, 60, 90, 180-s) and discharge voltage (3...
February 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29473044/cardiotoxicity-of-anticancer-therapeutics
#20
REVIEW
Jerry Dong, Hong Chen
As cancer therapeutics continues to improve and progress, the adverse side effects associated with anticancer treatments have also attracted more attention and have become extensively explored. Consequently, the importance of posttreatment follow-ups is becoming increasingly relevant to the discussion. Contemporary treatment methods, such as tyrosine kinase inhibitors, anthracycline chemotherapy, and immunotherapy regimens are effective in treating different modalities of cancers; however, these reagents act through interference with DNA replication or prevent DNA repair, causing endothelial dysfunction, generating reactive oxygen species, or eliciting non-specific immune responses...
2018: Frontiers in Cardiovascular Medicine
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