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https://www.readbyqxmd.com/read/27922187/tomentosin-induces-telomere-shortening-and-caspase-dependant-apoptosis-in-cervical-cancer-cells
#1
Nawel Merghoub, Hassan El Btaouri, Laila Benbacer, Saïd Gmouh, Chantal Trentesaux, Bertrand Brassart, Mohammed Attaleb, Claudie Madoulet, Thomas Wenner, Saaid Amzazi, Hamid Morjani, Mohamed El Mzibri
Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti-proliferative, telomere shortening and apoptotic effects on human cervical cancer HeLa and SiHa cell lines. Tomentosin was found to inhibit the growth of SiHa and HeLa cell lines in dose and time-dependent manner (IC50 values of 7.10 ± 0.78µM and 5.87 ± 0.36µM, respectively after 96h of treatment). As evidenced by TTAGGG telomere length assay, tomentosin target specifically the telomeric overhang lengthening...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27922176/dipeptidyl-peptidase-4-inhibitor-sitagliptin-reduces-inflammation-fibrosis-and-preserves-diastolic-function-in-a-rat-model-of-heart-failure-with-preserved-ejection-fraction
#2
Grazia Esposito, Donato Cappetta, Rosa Russo, Alessia Rivellino, Loreta Pia Ciuffreda, Fiorentina Roviezzo, Elena Piegari, L Liberato Berrino, Francesco Rossi, Antonella De Angelis, Konrad Urbanek
BACKGROUND AND PURPOSE: Heart failure with preserved ejection fraction (HFpEF) is a systemic syndrome driven by co-morbidities and its pathophysiology is poorly understood. Several studies suggesting that dipeptidyl peptidase 4 (DPP4) might be involved in the pathophysiology of heart failure prompted experimental and clinical investigations of DPP4 inhibitors on cardiovascular system. The aim of our study was to determine whether DPP4 inhibitor sitagliptin (SITA) affects the progression of HFpEF independently from the effects on glycaemia...
December 6, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27921399/antioxidant-and-antidiabetic-properties-of-tartary-buckwheat-rice-flavonoids-after-in-vitro-digestion
#3
Tao Bao, Ye Wang, Yu-Ting Li, Vemana Gowd, Xin-He Niu, Hai-Ying Yang, Li-Shui Chen, Wei Chen, Chong-de Sun
Oxidative stress and diabetes have a tendency to alter protein, lipid, and DNA moieties. One of the strategic methods used to reduce diabetes-associated oxidative stress is to inhibit the carbohydrate-digesting enzymes, thereby decreasing gastrointestinal glucose production. Plant-derived natural antioxidant molecules are considered a therapeutic tool in the treatment of oxidative stress and diabetes. The objective of this study was to identify tartary buckwheat rice flavonoids and evaluate the effect of in vitro digestion on their antioxidant and antidiabetic properties...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27921108/a-novel-antioxidant-peptide-derived-from-wheat-germ-prevents-high-glucose-induced-oxidative-stress-in-vascular-smooth-muscle-cells-in-vitro
#4
Siyuan Chen, Dingbo Lin, Yulong Gao, Xiaozhou Cao, Xinchun Shen
The ingestion of whole wheat products is responsible for the prevention of a number of chronic diseases. The aim of this study is to characterize the molecular properties of a novel wheat germ-derived antioxidant peptide (AOP) in protection against high glucose-induced oxidative stress in vascular smooth muscle cells (VSMCs). AOP (amino acid sequence AREGETVVPG) was isolated from wheat germ albumin using dual-enzymatic hydrolysis/separation, followed by MS/MS. The in vitro IC50 value for Fe(2+) chelation was 0...
December 6, 2016: Food & Function
https://www.readbyqxmd.com/read/27920727/genetic-targeting-of-arginase-ii-in-mouse-prevents-renal-oxidative-stress-and-inflammation-in-diet-induced-obesity
#5
Ji Huang, Angana Rajapakse, Yuyan Xiong, Jean-Pierre Montani, François Verrey, Xiu-Fen Ming, Zhihong Yang
Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L-arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase-II (Arg-II) in vascular endothelial cells promote uncoupling of endothelial nitric oxide synthase (eNOS), leading to increased superoxide radical anion and decreased NO production thereby endothelial dysfunction. Arg-II but not Arg-I is abundantly expressed in kidney and the role of Arg-II in CKD is uncertain and controversial...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27920337/effect-of-epigallocatechin-3-gallate-on-acrylamide-induced-oxidative-stress-and-apoptosis-in-pc12-cells
#6
Y He, D Tan, Y Mi, B Bai, D Jiang, X Zhou, S Ji
Acrylamide (ACR) is a chemical intermediate utilized in industry. ACR is also formed during heating of foods containing carbohydrates and amino acids. Therefore, humans are widely exposed to ACR, and ACR neurotoxicity in humans is a significant public health issue attracting wide attention. In this study, we investigated the potential neuroprotective effects of epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic compound in green tea, in PC12 cells treated with ACR. ACR-treated PC12 cells pretreated with various concentrations of EGCG (2...
December 5, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27919962/ascorbyl-stearate-promotes-apoptosis-through-intrinsic-mitochondrial-pathway-in-hela-cancer-cells
#7
Shirish D Mane, Maikho Thoh, Deepak Sharma, Santosh K Sandur, K Akhilender Naidu
BACKGROUND: Ascorbic acid is proposed to have antitumor potential against certain cancer types but has the limitation of requiring high doses for treating cancer. Ascorbyl stearate (ASC-S) is a fatty acid ester derivative of ascorbic acid with comparable potent apoptotic activity. The present study was aimed at understanding the pathway involved in apoptotic activity of ASC-S in cervical cancer cells. MATERIALS AND METHODS: The effect of ASC-S on reactive oxygen species (ROS), and mitochondrial membrane potential (MMP) was studied in HeLa cells...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919866/mitochondrial-dna-haplogroups-influence-the-risk-of-incident-knee-osteoarthritis-in-oai-and-check-cohorts-a-meta-analysis-and-functional-study
#8
Mercedes Fernández-Moreno, Angel Soto-Hermida, María E Vázquez-Mosquera, Estefanía Cortés-Pereira, Sara Relaño, Tamara Hermida-Gómez, Sonia Pértega, Natividad Oreiro-Villar, Carlos Fernández-López, Rafael Garesse, Francisco J Blanco, Ignacio Rego-Pérez
OBJECTIVE: To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential diagnostic biomarkers and therapeutic targets. METHODS: Two prospective cohorts contributed participants. The osteoarthritis initiative (OAI) included 2579 subjects of the incidence subcohort, and the cohort hip and cohort knee (CHECK) included 635, both with 8-year follow-up...
December 5, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27919855/uncoupling-protein-2-deficiency-reduces-proliferative-capacity-of-murine-pancreatic-stellate-cells
#9
Sarah Muller, Sandra Maria Klingbeil, Andreea Sandica, Robert Jaster
BACKGROUND: Uncoupling protein 2 (UCP2) has been suggested to inhibit mitochondrial production of reactive oxygen species (ROS) by decreasing the mitochondrial membrane potential. Experimental acute pancreatitis is associated with increased UCP2 expression, whereas UCP2 deficiency retards regeneration of aged mice from acute pancreatitis. Here, we have addressed biological and molecular functions of UCP2 in pancreatic stellate cells (PSCs), which are involved in pancreatic wound repair and fibrogenesis...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27919756/molecular-identification-and-functional-delineation-of-a-glutathione-reductase-homologue-from-disk-abalone-haliotis-discus-discus-insights-as-a-potent-player-in-host-antioxidant-defense
#10
H M L P B Herath, P D S U Wickramasinghe, S D N K Bathige, R G P T Jayasooriya, Gi-Young Kim, Myoung Ae Park, Chul Kim, Jehee Lee
Glutathione reductase (GSR) is an enzyme that catalyzes the biochemical conversion of oxidized glutathione (GSSG) into the reduced form (GSH). Since the ratio between the two forms of glutathione (GSH/GSSG) is important for the optimal function of GSH to act as an antioxidant against H2O2, the contribution of GSR as an enzymatic regulatory agent to maintain the proper ratio is essential. Abalones are marine mollusks that frequently encounter environmental factors that can trigger the overproduction of reactive oxygen species (ROS) such as H2O2...
December 2, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27919735/quercetin-attenuates-high-fructose-feeding-induced-atherosclerosis-by-suppressing-inflammation-and-apoptosis-via-ros-regulated-pi3k-akt-signaling-pathway
#11
Xue-Li Lu, Cui-Hua Zhao, Xin-Liang Yao, Han Zhang
Quercetin is a dietary flavonoid compound extracted from various plants, such as apple and onions. Previous studies have revealed its anti-inflammatory, anti-cancer, antioxidant and anti-apoptotic activities. This study investigated the ability of quercetin to inhibit high fructose feeding- or LPS-induced atherosclerosis through regulating oxidative stress, apoptosis and inflammation response in vivo and in vitro experiments. 50 and 100mg/kg quercetin were used in our study, showing significant inhibitory role in high fructose-induced atherosclerosis via reducing reactive oxygen species (ROS) levels, Caspase-3 activation, inflammatory cytokines releasing, the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive cells and collagen contents as well as modulating apoptosis- and inflammation-related proteins expression...
December 2, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27919636/adrenomedullin-and-angiotensin-ii-signaling-pathways-involved-in-the-effects-on-cerebellar-antioxidant-enzymes-activity
#12
Figueira Leticia, Israel Anita
Human adrenomedullin (AM) is a 52-amino acid peptide involved in cardiovascular control. AM has two specific receptors formed by the calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) 2 or 3, known as AM1 and AM2 receptors, respectively. In addition, AM has appreciable affinity for the calcitonin gene-1 related peptide receptor (CGRP1), composed of CRLR/RAMP1. In brain, AM and their receptors are expressed in several localized areas, including the cerebellum. AM has been reported as an antioxidant...
December 2, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27919191/phytotherapeutic-approach-a-new-hope-for-polycyclic-aromatic-hydrocarbons-induced-cellular-disorders-autophagic-and-apoptotic-cell-death
#13
Durgesh Nandini Das, Prashanta Kumar Panda, Prajna Paramita Naik, Subhadip Mukhopadhyay, Niharika Sinha, Sujit K Bhutia
Polycyclic aromatic hydrocarbons (PAHs) comprise the major class of cancer-causing chemicals and are ranked ninth among the chemical compounds threatening to humans. Moreover, interest in PAHs has been mainly due to their carcinogenic property, these compounds are genotoxic, teratogenic, mutagenic, and carcinogenic. Polymorphism in cytochrome P450 (CYP450) and aryl hydrocarbon receptor (AhR) have the capacity to convert procarcinogens into carcinogens, which is an imperative factor contributing to individual susceptibility to cancer development...
December 5, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27919184/role-of-engineered-metal-oxide-nanoparticle-agglomeration-in-reactive-oxygen-species-generation-and-cathepsin-b-release-in-nlrp3-inflammasome-activation-and-pulmonary-toxicity
#14
Tina M Sager, Michael Wolfarth, Stephen S Leonard, Anna M Morris, Dale W Porter, Vincent Castranova, Andrij Holian
Incomplete understanding of the contributions of dispersants and engineered nanoparticles/materials (ENM) agglomeration state to biological outcomes presents an obstacle for toxicological studies. Although reactive oxygen species (ROS) production is often regarded as the primary indicator of ENM bioactivity and toxicity, it remains unclear whether ENM produce ROS or whether ROS is an outcome of ENM-induced cell injury. Phagolysosomal disruption and cathepsin B release also promote bioactivity through inflammasome activation...
December 5, 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27918973/long-term-effects-of-cupric-oxide-nanoparticles-cuo-nps-on-the-performance-microbial-community-and-enzymatic-activity-of-activated-sludge-in-a-sequencing-batch-reactor
#15
Sen Wang, Zhiwei Li, Mengchun Gao, Zonglian She, Bingrui Ma, Liang Guo, Dong Zheng, Yangguo Zhao, Chunji Jin, Xuejiao Wang, Feng Gao
The long-term effects of cupric oxide nanoparticles (CuO NPs) on the performance, microbial activity and microbial community of activated sludge were investigated in a sequencing batch reactor (SBR). The SBR performance had no evident change at 0-10 mg/L CuO NPs, whereas the CuO NPs concentration at 30-60 mg/L affected the COD, NH4(+)-N and soluble orthophosphate (SOP) removal, nitrogen and phosphorus removal rate and microbial enzymatic activity of activated sludge. Some CuO NPs might be absorbed on the surface of activated sludge or penetrate the microbial cytomembrane into the microbial cell interior of activated sludge...
December 2, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27918959/specificity-protein-1-zinc-finger-protein-179-pathway-is-involved-in-the-attenuation-of-oxidative-stress-following-brain-injury
#16
Jian-Ying Chuang, Tzu-Jen Kao, Shu-Hui Lin, An-Chih Wu, Pin-Tse Lee, Tsung-Ping Su, Shiu-Hwa Yeh, Yi-Chao Lee, Chung-Che Wu, Wen-Chang Chang
After sudden traumatic brain injuries, secondary injuries may occur during the following days or weeks, which leads to the accumulation of reactive oxygen species (ROS). Since ROS exacerbate brain damage, it is important to protect neurons against their activity. Zinc finger protein 179 (Znf179) was shown to act as a neuroprotective factor, but the regulation of gene expression under oxidative stress remains unknown. In this study, we demonstrated an increase in Znf179 protein levels in both in vitro model of hydrogen peroxide (H2O2)-induced ROS accumulation and animal models of traumatic brain injury...
November 29, 2016: Redox Biology
https://www.readbyqxmd.com/read/27918874/effects-of-the-natural-%C3%AE-carboline-alkaloid-harmine-a-main-constituent-of-ayahuasca-in-memory-and-in-the-hippocampus-a-systematic-literature-review-of-preclinical-studies
#17
Rafael G Dos Santos, Jaime E C Hallak
Harmine is a natural β-carboline alkaloid found in several botanical species, such as the Banisteriopsis caapi vine used in the preparation of the hallucinogenic beverage ayahuasca and the seeds of Syrian rue (Peganum harmala). Preclinical studies suggest that harmine may have neuroprotective and cognitive-enhancing effects, and retrospective/observational investigations of the mental health of long-term ayahuasca users suggest that prolonged use of this harmine-rich hallucinogen is associated with better neuropsychological functioning...
December 5, 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27918563/dickkopf-1-promotes-hematopoietic-regeneration-via-direct-and-niche-mediated-mechanisms
#18
Heather A Himburg, Phuong L Doan, Mamle Quarmyne, Xiao Yan, Joshua Sasine, Liman Zhao, Grace V Hancock, Jenny Kan, Katherine A Pohl, Evelyn Tran, Nelson J Chao, Jeffrey R Harris, John P Chute
The role of osteolineage cells in regulating hematopoietic stem cell (HSC) regeneration following myelosuppression is not well understood. Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also known as Sp7 transcription factor 7)-expressing cells in mice promotes HSC regeneration and hematopoietic radioprotection following total body irradiation. These mice showed increased bone marrow (BM) levels of the protein dickkopf-1 (Dkk1), which was produced in Osx-expressing BM cells...
December 5, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27918455/targeting-on-asymmetric-dimethylarginine-related-nitric-oxide-reactive-oxygen-species-imbalance-to-reprogram-the-development-of-hypertension
#19
REVIEW
You-Lin Tain, Chien-Ning Hsu
Adult-onset diseases, including hypertension, can originate from early life, known as the developmental origins of health and disease (DOHaD). Because the developing kidney is vulnerable to early-life insults, renal programming is considered key in the developmental programming of hypertension. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, can regulate the NO-reactive oxygen species (ROS) balance, and is involved in the development of hypertension. Reprogramming interventions aimed at NO-ROS balance can be protective in both genetic and developmentally programmed hypertension...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27918246/rice-leaf-transcriptional-profiling-suggests-a-functional-interplay-between-xanthomonas-oryzae-pv-oryzae-lipopolysaccharide-and-extracellular-polysaccharide-in-modulation-of-defense-responses-during-infection
#20
Anil Madhusoodana Girija, Bipin Kumar Kumar, Madhavi B Mylavarapu, Palaparthi Ramesh, Sridivya Vungarala, Hitendra Kumar Patel, Ramesh Sonti
Treatment of rice leaves with isolated Xanthomonas oryzae pv. oryzae lipopolysaccharide (LPS) induces the production of callose deposits, reactive oxygen species and enhanced resistance against subsequent bacterial infection. Expression profiling of X. oryzae pv. oryzae LPS treated rice (Oryza sativa ssp. indica) leaves showed that genes involved in the biosynthetic pathways for lignins, phenylpropanoids, chorismate, phenylalanine, salicylic acid and ethylene as well as a number of pathogenesis related proteins are up regulated...
December 5, 2016: Molecular Plant-microbe Interactions: MPMI
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