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https://www.readbyqxmd.com/read/27903616/immediate-rule-out-of-acute-myocardial-infarction-using-electrocardiogram-and-baseline-high-sensitivity-troponin-i
#1
Johannes Tobias Neumann, Nils Arne Sörensen, Francisco Ojeda, Tjark Schwemer, Jonas Lehmacher, Saskia Gönner, Nikolas Jarsetz, Till Keller, Sarina Schaefer, Thomas Renné, Ulf Landmesser, Peter Clemmensen, Nataliya Makarova, Renate B Schnabel, Tanja Zeller, Mahir Karakas, John W Pickering, Martin Than, William Parsonage, Jaimi Greenslade, Louise Cullen, Dirk Westermann, Stefan Blankenberg
AIMS: Serial measurements of high-sensitivity troponin are used to rule out acute myocardial infarction (AMI) with an assay specific cutoff at the 99th percentile. Here, we evaluated the performance of a single admission troponin with a lower cutoff combined with a low risk electrocardiogram (ECG) to rule out AMI. METHODS: Troponin I measured with a high-sensitivity assay (hs-TnI) was determined at admission in 1040 patients presenting with suspected AMI (BACC study)...
November 30, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27872084/patient-perspectives-on-delays-in-diagnosis-and-treatment-of-cancer-a-qualitative-analysis-of-free-text-data
#2
Rachel K Parsonage, Julia Hiscock, Rebecca-Jane Law, Richard D Neal
BACKGROUND: Earlier cancer diagnosis is crucial in improving cancer survival. The International Cancer Benchmarking Partnership Module 4 (ICBP4) is a quantitative survey study that explores the reasons for delays in diagnosis and treatment of breast, colorectal, lung, and ovarian cancer. To further understand the associated diagnostic processes, it is also important to explore the patient perspectives expressed in the free-text comments. AIM: To use the free-text data provided by patients completing the ICBP4 survey to augment the understanding of patients' perspectives of their diagnostic journey...
November 21, 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27864992/the-mri-bullseye-sign-an-indicator-of-peripheral-nerve-constriction-in-parsonage-turner-syndrome
#3
Darryl B Sneag, Eliana B Saltzman, David W Meister, Joseph H Feinberg, Steve K Lee, Scott W Wolfe
INTRODUCTION: Magnetic resonance imaging's (MRI's) role in identifying hourglass constrictions (HGCs) of nerves in Parsonage-Turner syndrome (PTS) is largely unknown. METHODS: Six patients with PTS and with absent or minimal recovery underwent MRI. Surgical exploration was performed at identified pathologic sites. RESULTS: The time between symptom onset and surgery was 12.4 ± 6.9 months; the time between MRI and surgery was 1.3 ± 0...
November 16, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27846010/does-uric-acid-level-provide-additional-risk-stratification-information-in-emergency-patients-with-symptoms-of-possible-acute-coronary-syndrome
#4
Harry Jin, Jaimi H Greenslade, William A Parsonage, Tracey Hawkins, Martin Than, Louise Cullen
OBJECTIVE: Elevated uric acid levels have been associated with the presence and severity of coronary artery disease (CAD). This study aimed to assess the clinical utility of serum uric acid levels to identify patients at high risk of acute coronary syndrome (ACS) in those who presented to the emergency department (ED) with chest pain. METHODS: This was a prospective observational study of 951 adult patients who were being evaluated for ACS in a single ED. Serum uric acid was taken on presentation...
December 2016: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/27797440/the-association-of-electrocardiographic-abnormalities-and-major-adverse-cardiac-events-in-emergency-patients-with-chest-pain
#5
Thomas Knowlman, Jaimi H Greenslade, William Parsonage, Tracey Hawkins, Lorcan Ruane, Paul Martin, Sandhir Prasad, Daniel Lancini, Louise Cullen
OBJECTIVES: The electrocardiograph (ECG) is an essential tool in initial management and risk stratification of patients with suspected acute coronary syndrome (ACS). A six-point reporting criterion has been proposed to facilitate standardized clinical assessment of patients presenting to the emergency department (ED) with suspected ACS. We set out to evaluate the efficacy of these criteria in identifying patients with major adverse cardiac events (MACE), Type 1 myocardial infarction (T1MI), Type 2 myocardial infarction (T2MI), and one-year mortality in a cohort of emergency patients with chest pain...
October 31, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27754881/assessment-of-the-european-society-of-cardiology-0-hour-1-hour-algorithm-to-rule-out-and-rule-in-acute-myocardial-infarction
#6
John W Pickering, Jaimi H Greenslade, Louise Cullen, Dylan Flaws, William Parsonage, Sally Aldous, Peter George, Andrew Worster, Peter A Kavsak, Martin P Than
BACKGROUND: The new European Society of Cardiology guidelines to rule-in and rule-out acute myocardial infarction (AMI) in the emergency department include a rapid assessment algorithm based on high-sensitivity cardiac troponin and sampling at 0 and 1 hour. Emergency department physicians require high sensitivity to confidently rule-out AMI, whereas cardiologists aim to minimize false-positive results. METHODS: High-sensitivity troponin I and T assays were used to measure troponin concentrations in patients presenting with chest-pain symptoms and being investigated for possible acute coronary syndrome at hospitals in New Zealand, Australia, and Canada...
November 15, 2016: Circulation
https://www.readbyqxmd.com/read/27733174/use-of-the-theoretical-domains-framework-to-evaluate-factors-driving-successful-implementation-of-the-accelerated-chest-pain-risk-evaluation-acre-project
#7
Wade Skoien, Katie Page, William Parsonage, Sarah Ashover, Tanya Milburn, Louise Cullen
BACKGROUND: The translation of healthcare research into practice is typically challenging and limited in effectiveness. The Theoretical Domains Framework (TDF) identifies 12 domains of behaviour determinants which can be used to understand the principles of behavioural change, a key factor influencing implementation. The Accelerated Chest pain Risk Evaluation (ACRE) project has successfully translated research into practice, by implementing an intervention to improve the assessment of low to intermediate risk patients presenting to emergency departments (EDs) with chest pain...
October 12, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27672874/poster-107-bilateral-brachial-plexus-injury-tumor-traction-or-parsonage-turner-a-case-report
#8
Hardeep S Kainth, Ankit A Patel, Raymund V Millan
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27594682/peroxiredoxin-catalysis-at-atomic-resolution
#9
Arden Perkins, Derek Parsonage, Kimberly J Nelson, O Maduka Ogba, Paul Ha-Yeon Cheong, Leslie B Poole, P Andrew Karplus
Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases that guard cells against oxidative damage, are virulence factors for pathogens, and are involved in eukaryotic redox regulatory pathways. We have analyzed catalytically active crystals to capture atomic resolution snapshots of a PrxQ subfamily enzyme (from Xanthomonas campestris) proceeding through thiolate, sulfenate, and sulfinate species. These analyses provide structures of unprecedented accuracy for seeding theoretical studies, and reveal conformational intermediates giving insight into the reaction pathway...
October 4, 2016: Structure
https://www.readbyqxmd.com/read/27518132/parsonage-turner-syndrome-a-case-of-idiopathic-upper-extremity-paresis-following-middle-cranial-fossa-resection-of-a-vestibular-schwannoma
#10
James Prueter, Shawn M Stevens, Norberto Andaluz, Ravi N Samy
OBJECTIVE: In this patient report, Parsonage-Turner syndrome (acute brachial neuropathy) developed in our patient 1 day after resection of a vestibular schwannoma by a middle cranial fossa approach. Aiming to increase awareness of this rare disorder among neurotologists, we describe differential diagnoses, work-up, and management strategies. PATIENT: A 67-year-old man treated for vestibular schwannoma at a single tertiary referral center. INTERVENTION: Surgery for vestibular schwannoma, electromyography for confirmation of diagnosis, and physical therapy...
September 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27465009/agreement-between-patient-reported-and-cardiology-adjudicated-medical-history-in-patients-with-possible-ischemic-chest-pain-an-observational-study
#11
Alessandro Iliceto, Sara Louise Berndt, Jaimi H Greenslade, William A Parsonage, Christopher Hammett, Martin Than, Tracey Hawkins, Kate Parker, Shannen O'Kane, Louise Cullen
OBJECTIVE: Obtaining an accurate medical history is essential in the assessment of patients, particularly in emergency department (ED) patients with acute chest pain, as there can be a time imperative for diagnosis and commencement of treatment. We aimed to evaluate reliability of patient-reported compared with physician-adjudicated medical history by assessing patient's recall and communication of personal events and its influence on the accuracy of the medical history. METHODS: A total of 776 patients presenting at ED with suspected cardiac chest pain were recruited...
September 2016: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/27438316/evaluation-of-high-sensitivity-cardiac-troponin-i-levels-in-patients-with-suspected-acute-coronary-syndrome
#12
Edward Carlton, Jaimi Greenslade, Louise Cullen, Richard Body, Martin Than, John W Pickering, Sally Aldous, Simon Carley, Christopher Hammett, Jason Kendall, Brian Keevil, Sarah Lord, William Parsonage, Kim Greaves
IMPORTANCE: Low concentrations of high-sensitivity cardiac troponin I determined on presentation to the emergency department (ED) have been shown to have an excellent negative predictive value (NPV) for the identification of acute myocardial infarction. The sensitivity, and therefore clinical applicability, of such testing strategies is unknown. OBJECTIVE: To determine the diagnostic performance of low concentrations of high-sensitivity cardiac troponin I in patients with suspected cardiac chest pain and an electrocardiogram showing no ischemia as an indicator of acute myocardial infarction...
July 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27438315/diagnosis-of-myocardial-infarction-using-a-high-sensitivity-troponin-i-1-hour-algorithm
#13
Johannes Tobias Neumann, Nils Arne Sörensen, Tjark Schwemer, Francisco Ojeda, Rafael Bourry, Vanessa Sciacca, Sarina Schaefer, Christoph Waldeyer, Christoph Sinning, Thomas Renné, Martin Than, William Parsonage, Karin Wildi, Nataliya Makarova, Renate B Schnabel, Ulf Landmesser, Christian Mueller, Louise Cullen, Jaimi Greenslade, Tanja Zeller, Stefan Blankenberg, Mahir Karakas, Dirk Westermann
IMPORTANCE: Rapid and accurate diagnosis of acute myocardial infarction (AMI) currently constitutes an unmet need. OBJECTIVE: To test a 1-hour diagnostic algorithm to diagnose AMI using a high-sensitivity troponin I assay with a new cutoff level of 6 ng/L. DESIGN, SETTING, AND PARTICIPANTS: The Biomarkers in Acute Cardiac Care study is a prospective study that investigated the application of the troponin I assay for the diagnosis of AMI in 1040 patients presenting to the emergency department with acute chest pain from July 19, 2013, to December 31, 2014...
July 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27406833/external-validation-of-the-emergency-department-assessment-of-chest-pain-score-accelerated-diagnostic-pathway-edacs-adp
#14
Dylan Flaws, Martin Than, Frank Xavier Scheuermeyer, James Christenson, Barbara Boychuk, Jaimi H Greenslade, Sally Aldous, Christopher J Hammett, William A Parsonage, Joanne M Deely, John W Pickering, Louise Cullen
OBJECTIVE: The emergency department assessment of chest pain score accelerated diagnostic pathway (EDACS-ADP) facilitates low-risk ED chest pain patients early to outpatient investigation. We aimed to validate this rule in a North American population. METHODS: We performed a retrospective validation of the EDACS-ADP using 763 chest pain patients who presented to St Paul's Hospital, Vancouver, Canada, between June 2000 and January 2003. Patients were classified as low risk if they had an EDACS <16, no new ischaemia on ECG and non-elevated serial 0-hour and 2-hour cardiac troponin concentrations...
September 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27391838/reinterpretation-of-electrodiagnostic-studies-and-mris-in-patients-with-non-traumatic-isolated-anterior-interosseous-nerve-palsy
#15
Andrés A Maldonado, Kimberly K Amrami, Michelle L Mauermann, Robert J Spinner
INTRODUCTION: Different hypotheses have been proposed for the pathophysiology of anterior interosseous nerve (AIN) palsy: compression, fascicular constriction or nerve inflammation (Parsonage-Turner Syndrome). We hypothesized that critical reinterpretation of electrodiagnostic studies (EDX) and MRIs of patients with a diagnosis of AIN palsy could provide insight into the pathophysiology and treatment. MATERIALS AND METHODS: A retrospective review was performed of all patients with a diagnosis of non-traumatic AIN palsy and an upper extremity MRI performed at our institution...
July 5, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27390568/parsonage-turner-syndrome-clinical-and-epidemiological-features-from-a-hand-surgeon-s-perspective
#16
Chris S Milner, Kumar Kannan, Vasudeva G Iyer, Sunil M Thirkannad
BACKGROUND: Parsonage-Turner Syndrome (PTS) is a rare but serious condition characterized by spontaneous paresis of the upper extremity, typically lasting several months with variable recovery. With little literature on the behavior of PTS from a hand surgeon's perspective, accurate diagnosis and subsequent counseling of patients with PTS can be challenging. METHODS: This study is a retrospective evaluation of the clinical features of all PTS patients seen over a 9-year period...
June 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/27376569/ventricular-tachyarrhythmia-during-pregnancy-in-women-with-heart-disease-data-from-the-ropac-a-registry-from-the-european-society-of-cardiology
#17
Ebru Ertekin, Iris M van Hagen, Amar M Salam, Titia P E Ruys, Mark R Johnson, Jana Popelova, William A Parsonage, Zeinab Ashour, Avraham Shotan, José M Oliver, Gruschen R Veldtman, Roger Hall, Jolien W Roos-Hesselink
OBJECTIVES: To describe the incidence, onset, predictors and outcome of ventricular tachyarrhythmia (VTA) in pregnant women with heart disease. BACKGROUND: VTA during pregnancy will cause maternal morbidity and even mortality and will have impact on fetal outcome. Insufficient data exist on the incidence and outcome of VTA in pregnancy. METHODS AND RESULTS: From January 2007 up to October 2013, 99 hospitals in 39 countries enrolled 2966 pregnancies in women with structural heart disease...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27280627/atypical-pectoralis-major-muscle-wasting-in-a-recreational-weight-lifter
#18
Nata Parnes, Maryellen I Blevins, Paul Carey, Darren J Friedman
Pectoralis major injuries are relatively uncommon and can pose a diagnostic challenge. Deformity and weakness of this muscle in weight lifters is typically due to traumatic tendon rupture and often requires surgical repair. However, there are other less common etiologies that can mimic the clinical presentation of pectoralis major wasting and weakness that require different treatment approaches. This article describes a case of a 48-year-old recreational weight lifter who presented with severe pectoralis major wasting and weakness secondary to isolated mononeuropathy of the lateral pectoral nerve possibly due to Parsonage Turner syndrome...
July 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27043303/gender-differences-in-physical-performance-characteristics-of-elite-surfers
#19
Joanna Parsonage, Josh Secomb, Tai Tran, Oliver Farley, Sophia Nimphius, Lina Lundgren, Jeremy M Sheppard
The purpose of this study was to describe and compare the gender differences in physical performance characteristics of elite surfers. Twenty competitive female surfers (CFS) and twenty competitive male surfers (CMS) performed a battery of physical performance tests: squat Jump (SJ), isometric mid-thigh pull (IMTP), 15m-sprint paddle and 400m-endurance paddle) during a single testing session. All performance measures were significantly different between CFS and CMS (p<0.01). Specifically, CMS produced greater peak force production (28...
March 21, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27006109/global-cardiac-risk-assessment-in-the-registry-of-pregnancy-and-cardiac-disease-results-of-a-registry-from-the-european-society-of-cardiology
#20
Iris M van Hagen, Eric Boersma, Mark R Johnson, Sara A Thorne, William A Parsonage, Pilar Escribano Subías, Agata Leśniak-Sobelga, Olga Irtyuga, Khaled A Sorour, Nasser Taha, Aldo P Maggioni, Roger Hall, Jolien W Roos-Hesselink
AIMS: To validate the modified World Health Organization (mWHO) risk classification in advanced and emerging countries, and to identify additional risk factors for cardiac events during pregnancy. METHODS AND RESULTS: The ongoing prospective worldwide Registry Of Pregnancy And Cardiac disease (ROPAC) included 2742 pregnant women (mean age ± standard deviation, 29.2 ± 5.5 years) with established cardiac disease: 1827 from advanced countries and 915 from emerging countries...
May 2016: European Journal of Heart Failure
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