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https://www.readbyqxmd.com/read/29910357/the-assessment-of-isometric-dynamic-and-sports-specific-upper-body-strength-in-male-and-female-competitive-surfers
#1
Joanna Parsonage, Josh Secomb, Rebecca Dowse, Brendon Ferrier, Jeremy Sheppard, Sophia Nimphius
The primary purpose of this study was to investigate gender differences in the dynamic strength index (DSI): an assessment of upper-body dynamic strength relative to maximal isometric strength. The secondary purpose was to investigate gender differences in the dynamic skill deficit (DSD): an assessment of sports-specific dynamic strength relative to maximal isometric strength, and its association with a sports-specific performance measure in surfers. Nine male (age = 30.3 ± 7.3 yrs) and eight female (age = 25...
June 5, 2018: Sports
https://www.readbyqxmd.com/read/29884768/novel-hyperoxidation-resistance-motifs-in-2-cys-peroxiredoxins
#2
Jesalyn A Bolduc, Kimberly J Nelson, Alexina C Haynes, Jingyun Lee, Julie A Reisz, Aaron H Graff, Jill E Clodfelter, Derek Parsonage, Leslie B Poole, Cristina M Furdui, W Todd Lowther
2-Cys peroxiredoxins (Prxs) modulate hydrogen peroxide (H2 O2 )-mediated cell signaling. At high H2 O2  levels eukaryotic Prxs can be inactivated by hyperoxidation and are classified as sensitive Prxs. In contrast, prokaryotic Prxs are categorized as being resistant to hyperoxidation and lack the GGLG and C-terminal YF motifs present in the sensitive Prxs. Additional molecular determinants that account for the subtle differences in the susceptibility to hyperoxidation remain to be identified. A comparison of a new, 2...
June 8, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#3
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29691270/combining-high-sensitivity-cardiac-troponin-i-and-cardiac-troponin-t-in-the-early-diagnosis-of-acute-myocardial-infarction
#4
Noreen van der Linden, Karin Wildi, Raphael Twerenbold, John W Pickering, Martin Than, Louise Cullen, Jaimi Greenslade, William Parsonage, Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Maria Rubini Giménez, Lieke J J Klinkenberg, Otto Bekers, Aline Schöni, Dagmar I Keller, Zaid Sabti, Christian Puelacher, Janosch Cupa, Lukas Schumacher, Nikola Kozhuharov, Karin Grimm, Samyut Shrestha, Dayana Flores, Michael Freese, Claudia Stelzig, Ivo Strebel, Òscar Miró, Katharina Rentsch, Beata Morawiec, Damian Kawecki, Wanda Kloos, Jens Lohrmann, A Mark Richards, Richard Troughton, Christopher Pemberton, Stefan Osswald, Marja P van Dieijen-Visser, Alma M Mingels, Tobias Reichlin, Steven J R Meex, Christian Mueller
Background -Combining two signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction (AMI) with a single blood draw. We aimed to evaluate the diagnostic performance of combinations of high sensitivity (hs) cTnI and hs-cTnT for the early diagnosis of AMI. Methods -The diagnostic performance of combining hs-cTnI (Architect, Abbott) and hs-cTnT (Elecsys, Roche) concentrations (sum, product, ratio and a combination algorithm) obtained at the time of presentation was evaluated in a large multicenter diagnostic study of patients with suspected AMI...
April 24, 2018: Circulation
https://www.readbyqxmd.com/read/29685043/hepatitis-e-virus-in-neurological-disorders-a-case-of-parsonage-turner-syndrome
#5
María Sánchez Azofra, Miriam Romero Portales, Lucia Tortajada Laureiro, Javier García-Samaniego, Pedro Mora Sanz
Hepatitis E virus (HEV) infection is an emerging disease in developed countries with a broad clinical spectrum. In the absence of immunodeficiency or pregnancy, it is a mild and almost asymptomatic condition in most cases. However, extrahepatic manifestations, including neurological conditions, are common and may occasionally lead to permanent neurological sequelae. Herein, we report the case of an immunocompetent patient who was admitted to our hospital with paresthesia and weakness in both the upper extremities associated with anicteric-elevated transaminases...
June 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29624718/the-distribution-of-neuralgic-amyotrophy-lesions-is-overwhelmingly-extraplexal
#6
EDITORIAL
Mark A Ferrante
No abstract text is available yet for this article.
April 6, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29553725/differential-kinetics-of-two-cysteine-peroxiredoxin-disulfide-formation-reveal-a-novel-model-for-peroxide-sensing
#7
Stephanie Portillo-Ledesma, Lía M Randall, Derek Parsonage, Joaquín Dalla Rizza, P Andrew Karplus, Leslie B Poole, Ana Denicola, Gerardo Ferrer-Sueta
Two-cysteine peroxiredoxins (Prx) have a three-step catalytic cycle consisting of (1) reduction of peroxide and formation of sulfenic acid on the enzyme, (2) condensation of the sulfenic acid with a thiol to form disulfide, also known as resolution, and (3) reduction of the disulfide by a reductant protein. By following changes in protein fluorescence, we have studied the pH dependence of reaction 2 in human peroxiredoxins 1, 2, and 5 and in Salmonella typhimurium AhpC and obtained rate constants for the reaction and p Ka values of the thiol and sulfenic acid involved for each system...
March 30, 2018: Biochemistry
https://www.readbyqxmd.com/read/29496587/traumatic-brain-injury-a-potential-cause-of-violent-crime
#8
REVIEW
W Huw Williams, Prathiba Chitsabesan, Seena Fazel, Tom McMillan, Nathan Hughes, Michael Parsonage, James Tonks
Traumatic brain injury (TBI) is the biggest cause of death and disability in children and young people. TBI compromises important neurological functions for self-regulation and social behaviour and increases risk of behavioural disorder and psychiatric morbidity. Crime in young people is a major social issue. So-called early starters often continue for a lifetime. A substantial majority of young offenders are reconvicted soon after release. Multiple factors play a role in crime. We show how TBI is a risk factor for earlier, more violent, offending...
February 26, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29469611/scoring-analysis-of-the-men-s-2014-2015-and-2016-world-championship-tour-of-surfing-the-importance-of-aerial-manoeuvres-in-competitive-surfing
#9
Brendon Ferrier, Jeremy Sheppard, Oliver R L Farley, Josh L Secomb, Joanna Parsonage, Robert U Newton, Sophia Nimphius
The aim of this study was to investigate the impact of aerial manoeuvres on scoring in professional surfing. 23,631 waves were analysed for the number and types of aerial manoeuvres performed from the 2014, 2015 and 2016 Men's World Championship Tour. Additionally, the awarded score, timing and order of the aerial was also analysed. Descriptive statistics and Two Way ANOVA's were performed with Sidak Multiple Comparisons Post Hoc analysis. Results were a significantly higher score being awarded (P ≤ 0.0001) when including an aerial in competition across all three seasons...
February 22, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29461642/brachial-plexitis-or-neuritis-mri-features-of-lesion-distribution-in-parsonage-turner-syndrome
#10
Darryl B Sneag, Schneider K Rancy, Scott W Wolfe, Susan C Lee, Vivek Kalia, Steve K Lee, Joseph H Feinberg
INTRODUCTION: This study seeks to characterize lesion distribution in Parsonage-Turner Syndrome (PTS) using high-resolution MRI. METHODS: MRIs of 27 patients with clinically confirmed PTS were reviewed. Two radiologists independently evaluated the brachial plexus proper, side and terminal plexus branches, and more distal, upper extremity nerves. RESULTS: All patients had at least 1 clinically involved nerve. MRI revealed that the plexus appeared normal in 24 of 27 patients; in 3 other patients, signal hyperintensity was seen immediately proximal to the take-off of abnormal side or terminal branch nerves...
February 20, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29419380/evaluating-rapid-rule-out-of-acute-myocardial-infarction-using-a-high-sensitivity-cardiac-troponin-i-assay-at-presentation
#11
Jaimi Greenslade, Elizabeth Cho, Christopher Van Hise, Tracey Hawkins, William Parsonage, Jacobus Ungerer, Jillian Tate, Carel Pretorius, Martin Than, Louise Cullen
BACKGROUND: Low concentrations of cardiac troponin (cTn) have been recommended for rapid rule-out of acute myocardial infarction (AMI). We examined the Beckman Coulter Access high-sensitivity cardiac troponin I (hs-cTnI) assay to identify a single test threshold that can safely rule out AMI. METHODS: This analysis used stored samples collected in 2 prospective observational studies. In all, 1871 patients presenting to a tertiary emergency department with symptoms of acute coronary syndrome had blood taken for measurement of cTnI on presentation...
May 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29302830/gender-specific-trajectories-of-conduct-problems-from-ages-3-to-11
#12
Leslie Morrison Gutman, Heather Joshi, Michael Parsonage, Ingrid Schoon
Gender-specific pathways of conduct problems (CP) from toddlerhood have received little attention. Using a nationally representative sample of UK children born in 2000-2001 (6458 boys and 6340 girls), the current study (a) identified subgroups of CP pathways separately for boys and girls from ages 3 to 11 and (b) examined early precursors (pregnancy to 9 months) of these trajectories. Group-based trajectory models identified four distinct trajectories for both boys and girls: each characterized as 'low'; 'early-onset, desisting'; 'early-onset, persistent' and 'school-onset'...
January 5, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29248334/diagnostic-accuracy-of-a-new-high-sensitivity-troponin-i-assay-and-five-accelerated-diagnostic-pathways-for-ruling-out-acute-myocardial-infarction-and-acute-coronary-syndrome
#13
Jaimi H Greenslade, Edward W Carlton, Christopher Van Hise, Elizabeth Cho, Tracey Hawkins, William A Parsonage, Jillian Tate, Jacobus Ungerer, Louise Cullen
STUDY OBJECTIVE: This diagnostic accuracy study describes the performance of 5 accelerated chest pain pathways, calculated with the new Beckman's Access high-sensitivity troponin I assay. METHODS: High-sensitivity troponin I was measured with presentation and 2-hour blood samples in 1,811 patients who presented to an emergency department (ED) in Australia. Patients were classified as being at low risk according to 5 rules: modified accelerated diagnostic protocol to assess patients with chest pain symptoms using troponin as the only biomarker (m-ADAPT), the Emergency Department Assessment of Chest Pain Score (EDACS) pathway, the History, ECG, Age, Risk Factors, and Troponin (HEART) pathway, the No Objective Testing Rule, and the new Vancouver Chest Pain Rule...
April 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29239996/upper-body-strength-measures-and-pop-up-performance-of-stronger-and-weaker-surfers
#14
Joanna Parsonage, Josh L Secomb, Jeremy M Sheppard, Brendon K Ferrier, Rebecca A Dowse, Sophia Nimphius
The primary purpose of this study was to investigate the reliability of the isometric push-up (IPU), dynamic push-up (DPU), and force plate pop-up (FP POP) as measures of upper-body isometric and dynamic strength qualities in surfing athletes. Furthermore, the study aimed to compare pop-up performance between stronger and weaker surfers. Eighteen female (n=9) and male (n=9) surfers (age=28.1±6.4 yrs, mass=69.6±10.4 kg, height=172.5±6.7 cm) completed a battery of upper-body strength assessments, of which exhibited high between-day reliability: (IPU, (CV%=4...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29232768/modification-of-the-thrombolysis-in-myocardial-infarction-risk-score-for-patients-presenting-with-chest-pain-to-the-emergency-department
#15
Jaimi H Greenslade, Kimberly Chung, William A Parsonage, Tracey Hawkins, Martin Than, John W Pickering, Louise Cullen
OBJECTIVE: To develop a modified Thrombolysis in Myocardial Infarction (TIMI) score to effectively risk stratify patients presenting to the ED with chest pain. METHODS: A prospective observational study was conducted at two metropolitan EDs. Data were obtained during patient interview. The primary outcome was major adverse cardiovascular events (MACE) within 30 days of presentation. Two separate modifications of the TIMI score were developed. These scores were compared to the original TIMI in terms of the area under the receiver operating characteristic curve and diagnostic accuracy statistics (sensitivity, specificity, positive and negative predictive values)...
February 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29230212/a-novel-function-for-the-streptococcus-pneumoniae-aminopeptidase-n-inhibition-of-t-cell-effector-function-through-regulation-of-tcr-signaling
#16
Lance K Blevins, Derek Parsonage, Melissa B Oliver, Elizabeth Domzalski, W Edward Swords, Martha A Alexander-Miller
Streptococcus pneumoniae ( Spn ) causes a variety of disease states including fatal bacterial pneumonia. Our previous finding that introduction of Spn into an animal with ongoing influenza virus infection resulted in a CD8+ T cell population with reduced effector function gave rise to the possibility of direct regulation by pneumococcal components. Here, we show that treatment of effector T cells with lysate derived from Spn resulted in inhibition of IFNγ and tumor necrosis factor α production as well as of cytolytic granule release...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163414/control-of-antimicrobial-resistance-requires-an-ethical-approach
#17
REVIEW
Ben Parsonage, Philip K Hagglund, Lloyd Keogh, Nick Wheelhouse, Richard E Brown, Stephanie J Dancer
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the prospect of declining anti-infectives affects everyone. Without preventive action, loss of drugs that have saved lives over the past century, will condemn ourselves, people we know, and people we don't know, to unacceptable risk of untreatable infection. Policies aimed at extending antimicrobial life should be considered within an ethical framework, in order to balance the choice, range, and quality of drugs against stewardship activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29138293/icare-acs-improving-care-processes-for-patients-with-suspected-acute-coronary-syndrome-a-study-of-cross-system-implementation-of-a-national-clinical-pathway
#18
Martin P Than, John W Pickering, Jeremy M Dryden, Sally J Lord, S Andrew Aitken, Sally J Aldous, Kate E Allan, Michael W Ardagh, John W N Bonning, Rosie Callender, Laura R E Chapman, Jonathan P Christiansen, Andre P J Cromhout, Louise Cullen, Joanne M Deely, Gerard P Devlin, Katherine A Ferrier, Christopher M Florkowski, Christopher M A Frampton, Peter M George, Gregory J Hamilton, Allan S Jaffe, Andrew J Kerr, G Luke Larkin, Richard M Makower, Timothy J E Matthews, William A Parsonage, W Frank Peacock, Bradley F Peckler, Niels C van Pelt, Louise Poynton, A Mark Richards, Anthony G Scott, Mark B Simmonds, David Smyth, Oliver P Thomas, Andrew C Y To, Stephen A Du Toit, Richard W Troughton, Kim M Yates
BACKGROUND: Efforts to safely reduce length of stay for emergency department patients with symptoms suggestive of acute coronary syndrome (ACS) have had mixed success. Few system-wide efforts affecting multiple hospital emergency departments have ever been evaluated. We evaluated the effectiveness of a nationwide implementation of clinical pathways for potential ACS in disparate hospitals. METHODS: This was a multicenter pragmatic stepped-wedge before-and-after trial in 7 New Zealand acute care hospitals with 31 332 patients investigated for suspected ACS with serial troponin measurements...
January 23, 2018: Circulation
https://www.readbyqxmd.com/read/29131477/a-risk-assessment-score-and-initial-high-sensitivity-troponin-combine-to-identify-low-risk-of-acute-myocardial-infarction-in-the-emergency-department
#19
John W Pickering, Dylan Flaws, Stephen W Smith, Jaimi Greenslade, Louise Cullen, William Parsonage, Edward Carlton, A Mark Richards, Richard Troughton, Christopher Pemberton, Peter M George, Martin P Than
OBJECTIVES: Early discharge of patients with presentations triggering assessment for possible acute coronary syndrome (ACS) is safe when clinical assessment indicates low risk, biomarkers are negative, and electrocardiograms (ECGs) are nonischemic. We hypothesized that the Emergency Department Assessment of Chest Pain Score (EDACS) combined with a single measurement of high-sensitivity cardiac troponin (hs-cTn) could allow early discharge of a clinically meaningful proportion of patients...
April 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29127948/association-of-high-sensitivity-cardiac-troponin-i-concentration-with-cardiac-outcomes-in-patients-with-suspected-acute-coronary-syndrome
#20
REVIEW
Andrew R Chapman, Kuan Ken Lee, David A McAllister, Louise Cullen, Jaimi H Greenslade, William Parsonage, Andrew Worster, Peter A Kavsak, Stefan Blankenberg, Johannes Neumann, Nils A Sörensen, Dirk Westermann, Madelon M Buijs, Gerard J E Verdel, John W Pickering, Martin P Than, Raphael Twerenbold, Patrick Badertscher, Zaid Sabti, Christian Mueller, Atul Anand, Philip Adamson, Fiona E Strachan, Amy Ferry, Dennis Sandeman, Alasdair Gray, Richard Body, Brian Keevil, Edward Carlton, Kim Greaves, Frederick K Korley, Thomas S Metkus, Yader Sandoval, Fred S Apple, David E Newby, Anoop S V Shah, Nicholas L Mills
Importance: High-sensitivity cardiac troponin I testing is widely used to evaluate patients with suspected acute coronary syndrome. A cardiac troponin concentration of less than 5 ng/L identifies patients at presentation as low risk, but the optimal threshold is uncertain. Objective: To evaluate the performance of a cardiac troponin I threshold of 5 ng/L at presentation as a risk stratification tool in patients with suspected acute coronary syndrome. Data Sources: Systematic search of MEDLINE, EMBASE, Cochrane, and Web of Science databases from January 1, 2006, to March 18, 2017...
November 21, 2017: JAMA: the Journal of the American Medical Association
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