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https://www.readbyqxmd.com/read/29042240/coxiella-burnetii-and-rickettsia-conorii-two-zoonotic-pathogens-in-peridomestic-rodents-and-their-ectoparasites-in-nigeria
#1
Joshua Kamani, Gad Baneth, Ricardo Gutiérrez, Yaarit Nachum-Biala, Kosta Y Mumcuoglu, Shimon Harrus
Rodents are hosts of numerous pathogenic agents of public health importance globally. Their ability to harbor these pathogens without showing overt clinical signs of disease has epidemiologic consequences. In some rural settings in Nigeria, humans and rodents do not only share feeds and abode, but the latter may end up on the table of the former as a source of protein, thereby increasing the risks of disease transmission. Molecular assays were used to detect and characterize two agents of zoonotic importance, Coxiella burnetii and Rickettsia spp...
October 12, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29040955/protective-role-of-epigallocatechin-3-gallate-on-arsenic-induced-testicular-toxicity-in-swiss-albino-mice
#2
Pushpa Rani Guvvala, Janivara Parameswaraiah Ravindra, Chukkath Vijayan Rajani, Muniandy Sivaram, Sellappan Selvaraju
Arsenic, often referred to as the king of poisons is carcinogenic in humans and animals. It affects multiorgan systems including reproduction. The present study was undertaken to explore the protective role of green tea compound, epigallocatechin-3-gallate (EGCG) on arsenic induced testicular toxicity in Swiss albino mice. Thirty two adult male mice were randomly assigned to four groups (n=8). Group I served as control without test chemical. The group II received arsenic (200ppm) through drinking water, group III received only EGCG (20mg/kgb...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29037558/monozygotic-twins-discordant-for-trisomy-21-discussion-of-etiological-events-involved
#3
Yao-Lung Chang, Wu-Pei Yi, An-Shine Chao, Kuan-Ju Chen, Po-Jen Cheng, Tzu-Hao Wang, Shuenn-Dyh Chang
OBJECTIVE: To elucidate the etiologies of discordant trisomy 21 in monozygotic twin pregnancy. CASE REPORT: A monochorionic diamniotic twin pregnancy with hydrops and cleft lip (twin 1) found in one fetus presented at gestational age of 17 weeks. Amniotic fluid karyotyping showed nonmosaic trisomy 21 in twin 1 (47, XY, +21 [20]) and a normal karyotype in twin 2 (46, XY [20]). Short tandem repeat (STR) polymorphism markers revealed that the two fetuses were monozygotic, and the two chromosomes 21 were maternal isodisomy in the trisomy fetus...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29034897/generation-of-ipsc-line-from-desmin-related-cardiomyopathy-patient-carrying-splice-site-mutation-of-des-gene
#4
Aleksandr Khudiakov, Daria Kostina, Anna Zlotina, Tatiana Nikulina, Alexey Sergushichev, Alexandra Gudkova, Alexey Tomilin, Anna Malashicheva, Anna Kostareva
Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying desmin (DES) gene heterozygous splice site mutation using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai viruses. iPSCs were characterized by sequencing, karyotype analysis, STR analysis, immunocytochemistry, RT-PCR and teratoma formation.
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29028926/structure-based-prediction-of-protein-peptide-binding-regions-using-random-forest
#5
Ghazaleh Taherzadeh, Yaoqi Zhou, Alan Wee-Chung Liew, Yuedong Yang
Motivation: Protein-peptide interactions are one of the most important biological interactions and play crucial role in many diseases including cancer. Therefore, knowledge of these interactions provides invaluable insights into all cellular processes, functional mechanisms, and drug discovery. Protein-peptide interactions can be analyzed by studying the structures of protein-peptide complexes. However, only a small portion has known complex structures and experimental determination of protein-peptide interaction is costly and inefficient...
September 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29024041/strength-training-improves-double-poling-performance-after-prolonged-submaximal-exercise-in-cross-country-skiers
#6
S Øfsteng, Ø Sandbakk, M van Beekvelt, D Hammarström, R Kristoffersen, J Hansen, G Paulsen, B R Rønnestad
The purpose of this study was to investigate the effects of adding strength training with or without vibration to cross-country (XC) skiers' endurance training on double poling (DP) performance, physiological and kinematic adaptations. Twenty-one well-trained male XC skiers combined endurance- and upper-body strength-training three times per week, either with (n=11) or without (n=10) superimposed vibrations for 8 weeks, whereas eight skiers performed endurance training only (CON). Testing included 1RM in upper-body exercises, work economy, neural activation, oxygen saturation in muscle and DP kinematics during a prolonged submaximal DP roller ski test which was directly followed by a time to exhaustion (TTE) test...
October 10, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29023015/evaluation-of-growth-performances-of-some-locally-farmed-maize-zea-mays-l-in-cross-river-state-nigeria-under-different-concentrations-of-silicon
#7
M O Ononyume, E A Edu, T Okoh, A P Inegbedion
OBJECTIVE: Growth performances of four maize varieties (91 SUWANI, TZL COMP 4, DT STR Y SYN 2 and IWO SYN C2) were investigated at four levels of silicon concentration (0, 2500, 5000 and 7500 mg, with 0 mg as control). METHODOLOGY: Viable seeds were planted in polythene bags (64 bags) containing soil in a randomized complete block design (a 4×4 factorial experiment) with four replications. Plant height, stem girth, leaf area and leaf number were evaluated at 4, 6, 8 and 10 weeks after planting...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29016685/lactobacillus-rhamnosus-pb01-dsm-14870-supplementation-affects-markers-of-sperm-kinematic-parameters-in-a-diet-induced-obesity-mice-model
#8
Fereshteh Dardmeh, Hiva Alipour, Parisa Gazerani, Gerhard van der Horst, Erik Brandsborg, Hans Ingolf Nielsen
Probiotics have been proposed as alternatives to pharmacological products in several medical conditions including the modulation of obesity, which is frequently associated with poor semen quality. However, effects of probiotics on male fertility have been less investigated. This study assessed the effect of Lactobacillus rhamnosus PB01 (DSM-14870) on sperm kinematic parameters in Normal-weight (NW) and diet-induced obese (DIO) models. NW and DIO C57BL/6NTac mice were divided into two subgroups with or without a single daily dose (1x109CFU) of L...
2017: PloS One
https://www.readbyqxmd.com/read/28994142/appropriate-use-of-echocardiography-and-relation-to-clinical-decision-making-in-both-inpatients-and-outpatients-in-a-developing-country
#9
Minna Moreira Dias Romano, Marina Branco, Henrique Turin Moreira, André Schmidt, Joseph Kisslo, Benedito Carlos Maciel
BACKGROUND: Use of echocardiography (echo) has exponentially increased in recent decades. Concerned about this scientific society developed appropriate use criteria (AUC). Clinical management still suffers geographical variations, and no objective data are available about echo AUC in developing countries. We aimed to evaluate (1) the appropriateness of referrals and (2) their relation to changes in clinical decision management. METHODS: Prospective analysis of referrals from January to December 2014...
October 10, 2017: Echocardiography
https://www.readbyqxmd.com/read/28984185/strscan-targeted-profiling-of-short-tandem-repeats-in-whole-genome-sequencing-data
#10
Haixu Tang, Etienne Nzabarushimana
BACKGROUND: Short tandem repeats (STRs) are found in many prokaryotic and eukaryotic genomes, and are commonly used as genetic markers, in particular for identity and parental testing in DNA forensics. The unstable expansion of some STRs was associated with various genetic disorders (e.g., the Huntington disease), and thus was used in genetic testing for screening individuals at high risk. Traditional STR analyses were based on the PCR amplification of STR loci followed by gel electrophoresis...
October 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28981921/-mutational-analysis-and-prenatal-diagnosis-in-a-family-affected-with-hypophosphatemic-rickets
#11
Zhaotang Luan, Huanzheng Li, Lin Hu, Chong Chen, Xueqin Xu, Yanbao Xiang, Shaohua Tang
OBJECTIVE: To explore the clinical characteristics and genetic mutation in a family affected with hypophosphatemic rickets. METHODS: Whole exome sequencing (WES) was used to screen potential mutations in genomic DNA extracted from peripheral venous blood sample from the proband. Suspected mutation was confirmed with Sanger sequencing. Amniotic fluid was sampled from the proband for prenatal diagnosis. Potential maternal contamination was excluded by analysis of short tandem repeat (STR) markers...
October 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28979290/y-str-haplogroup-diversity-in-the-jat-population-reveals-several-different-ancient-origins
#12
David G Mahal, Ianis G Matsoukas
The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancient people that arrived and lived in northern India at one time. Essentially, the specific origin of these people has remained a matter of contention for a long time. This study demonstrated that the origins of Jats can be clarified by identifying their Y-chromosome haplogroups and tracing their genetic markers on the Y-DNA haplogroup tree...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28974626/bama-%C3%AE-6c-strand-and-periplasmic-turns-are-critical-for-outer-membrane-protein-insertion-and-assembly
#13
Yinghong Gu, Yi Zeng, Zhongshan Wang, Changjiang Dong
Outer membrane β-barrel proteins play important roles in importing nutrients, exporting wastes and conducting signals in Gram-negative bacteria, mitochondria and chloroplasts. The outer membrane proteins are inserted and assembled into the outer membrane by OMP85 family proteins. In Escherichia coli , the b-barrel assembly machinery (BAM) contains four lipoproteins BamB, BamC, BamD and BamE, and one outer membrane protein BamA, forming a "top hat"-like structure. Structural and functional studies of the E...
October 3, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28970706/brain-microstructural-correlates-of-cognitive-dysfunction-in-clinically-and-biochemically-normal-hepatitis-c-virus-infection
#14
Ajay Kumar, Amar Deep, Rakesh K Gupta, Virendra Atam, Samir Mohindra
BACKGROUND/AIMS: This study examined correlates of the brain's neurocognitive performance among clinically and biochemically normal adult patient with hepatitis C virus (HCV). We hypothesized that anti-HCV positive individuals would demonstrate structural brain abnormalities and neurocognitive dysfunction as well as the changes in cell component and extracellular space in the white matter regions of brain in asymptomatic HCV infection by using diffusion tensor tractrography (DTT) metrics...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28965417/protein-level-integration-strategy-of-multiengine-ms-spectra-search-results-for-higher-confidence-and-sequence-coverage
#15
Panpan Zhao, Jiayong Zhong, Wanting Liu, Jing Zhao, Gong Zhang
Multiple search engines based on various models have been developed to search MS/MS spectra against a reference database, providing different results for the same data set. How to integrate these results efficiently with minimal compromise on false discoveries is an open question due to the lack of an independent, reliable, and highly sensitive standard. We took the advantage of the translating mRNA sequencing (RNC-seq) result as a standard to evaluate the integration strategies of the protein identifications from various search engines...
October 11, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28963682/comprehensive-examination-of-conventional-and-innovative-body-fluid-identification-approaches-and-dna-profiling-of-laundered-blood-and-saliva-stained-pieces-of-cloths
#16
G Kulstein, P Wiegand
Body fluids like blood and saliva are commonly encountered during investigations of high volume crimes like homicides. The identification of the cellular origin and the composition of the trace can link suspects or victims to a certain crime scene and provide a probative value for criminal investigations. To erase all traces from the crime scene, perpetrators often wash away their traces. Characteristically, items that show exposed stains like blood are commonly cleaned or laundered to free them from potential visible leftovers...
September 29, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28958923/clinical-features-treatment-and-long-term-outcomes-of-central-neurocytoma-a-20-year-experience-at-a-single-center
#17
Mengmeng Wang, Peizhi Zhou, Shizhen Zhang, Xueyou Liu, Liang Lv, Zeming Wang, Feng Ye, Xiang Wang, Shu Jiang
OBJECTIVE: Central neurocytoma (CN) is a rare central nervous system tumor whose optimal management strategy remains controversial due to their rarity. A thorough research of detail information of CN is very necessary to establish optimal management strategies. The purpose of this study was to demonstrate the clinical features, treatments and long-term clinical outcomes of CN. METHODS: A total of 63 cases with CN were surgically treated between 1995 and 2016 at West China Hospital...
September 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28957691/differential-rubisco-content-and-photosynthetic-efficiency-of-rol-gene-integrated-vinca-minor-transgenic-plant-correlating-factors-associated-with-morpho-anatomical-changes-gene-expression-and-alkaloid-productivity
#18
Priyanka Verma, Shamshad Ahmad Khan, Nusrat Masood, N Manika, Abhishek Sharma, Neha Verma, Suaib Luqman, Ajay K Mathur
Transgenic plants obtained from a hairy root line (PVG) of Vinca minor were characterized in relation to terpenoid indole alkaloids (TIAs) pathway gene expression and vincamine production. The hairy roots formed callus with green nodular protuberances when transferred onto agar-gelled MS medium containing 3.0mg/l zeatin. These meristematic zones developed into shoot buds on medium with 1.0mg/l 2, 4-dichlorophenoxyacetic acid and 40mg/l ascorbic acid. These shoot buds subsequently formed rooted plants when shifted onto a hormone-free MS medium with 6% sucrose...
September 20, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28956148/rna-dna-co-analysis-from-bloodstains-on-aged-polyvinyl-alcohol-gloves-prepared-for-securing-evidence-from-the-hands-of-victims-of-fatal-gunshot-injuries
#19
Melanie Grabmüller, Cornelius Courts, Burkhard Madea, Tim Eichhorst, Christian Schyma
In contrast to cumulative techniques (e.g., tape-lift) for qualitative gunshot residues (GSR) analysis, topographic methods are commonly applied to preserve the integrity of evidence from a shooter's or victim's hand in cases of gun-related crimes. Topographic sampling techniques employing adhesive foils, latex, or the polyvinyl alcohol (PVAL) method enable unambiguous sampling of biological and non-biological trace material while preserving its spatial distribution and relation to each other. The PVAL method in particular allows for a topographically veridic and quantitative conservation of traces of GSR and biological stains that are embedded in the PVAL glove, because it completely removes these traces from the hand...
September 27, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28956146/comparative-tolerance-of-two-massively-parallel-sequencing-systems-to-common-pcr-inhibitors
#20
Kyleen Elwick, Xiangpei Zeng, Jonathan King, Bruce Budowle, Sheree Hughes-Stamm
Human remains can be severely affected by the environment, and the DNA may be damaged, degraded, and/or inhibited. In this study, a DNA sample (at 1 ng DNA target input in triplicate) was spiked with five concentrations of five inhibitors (humic acid, melanin, hematin, collagen, and calcium) and sequenced with both the HID-Ion AmpliSeq™ Library Kit and ID panel on the Ion PGM™ System and the ForenSeq DNA Signature Prep Kit on the MiSeq FGx™. The objective of this study was to compare the baseline tolerance of the two sequencing chemistries and platforms to common inhibitors encountered in human remains recovered from missing person cases...
September 27, 2017: International Journal of Legal Medicine
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