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Bioprinting

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https://www.readbyqxmd.com/read/29148982/a-dentin-derived-hydrogel-bioink-for-3d-printing-of-cell-laden-scaffolds-for-regenerative-dentistry
#1
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane Miranda Franca, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
November 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/29147690/physiological-ph-dependent-gelation-for-3d-printing-based-on-the-phase-separation-of-gelatin-and-oxidized-dextran
#2
Zengmin Du, Ningfeng Li, Yujie Hua, Yong Shi, Chunyan Bao, Hongbo Zhang, Yi Yang, Qiuning Lin, Linyong Zhu
An extrudable hydrogel with a tunable gelation time under physiological pH ranges based on the phase separation of gelatin and oxidized dextran was demonstrated. We envision that the easy handing properties of this hydrogel combined with thermosensitive physical gelation and postponed chemical reinforcing will provide a platform for 3D bioprinting applications.
November 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29139103/differentiation-potential-of-human-adipose-stem-cells-bioprinted-with-hyaluronic-acid-gelatin-based-bioink-through-microextrusion-and-visible-light-initiated-crosslinking
#3
Shinji Sakai, Hiromi Ohi, Tomoki Hotta, Hidenori Kamei, Masahito Taya
Bioprinting has a great potential to fabricate three-dimensional (3D) functional tissues and organs. In particular, the technique enables fabrication of 3D constructs containing stem cells while maintaining cell proliferation and differentiation abilities, which is believed to be promising in the fields of tissue engineering and regenerative medicine. We aimed to demonstrate the utility of the bioprinting technique to create hydrogel constructs consisting of hyaluronic acid (HA) and gelatin derivatives through irradiation by visible light to fabricate 3D constructs containing human adipose stem cells (hADSCs)...
November 15, 2017: Biopolymers
https://www.readbyqxmd.com/read/29134949/pla-short-sub-micron-fiber-reinforcement-of-3d-bioprinted-alginate-constructs-for-cartilage-regeneration
#4
Alicja Kosik-Kozioł, Marco Costantini, Tomasz Bolek, Krisztina Szöke, Andrea Barbetta, Jan Brinchmann, Wojciech Święszkowski
In this study, we present an innovative strategy to reinforce 3D-printed hydrogel constructs for cartilage tissue engineering by formulating composite bioinks containing alginate and short sub-micron polylactide (PLA) fibers. We demonstrate that Young's modulus obtained for pristine alginate constructs (6.9 ± 1.7 kPa) can be increased threefold (up to 25.1 ± 3.8 kPa) with the addition of PLA short fibers. Furthermore, to assess the performance of such materials in cartilage tissue engineering, we loaded the bioinks with human chondrocytes and cultured in vitro the bioprinted constructs for up to 14 days...
November 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/29132232/embedded-multimaterial-extrusion-bioprinting
#5
Marco Rocca, Alessio Fragasso, Wanjun Liu, Marcel A Heinrich, Yu Shrike Zhang
Embedded extrusion bioprinting allows for the generation of complex structures that otherwise cannot be achieved with conventional layer-by-layer deposition from the bottom, by overcoming the limits imposed by gravitational force. By taking advantage of a hydrogel bath, serving as a sacrificial printing environment, it is feasible to extrude a bioink in freeform until the entire structure is deposited and crosslinked. The bioprinted structure can be subsequently released from the supporting hydrogel and used for further applications...
November 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29120815/3d-neural-tissue-models-from-spheroids-to-bioprinting
#6
REVIEW
Pei Zhuang, Alfred Xuyang Sun, Jia An, Chee Kai Chua, Sing Yian Chew
Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications...
November 7, 2017: Biomaterials
https://www.readbyqxmd.com/read/29119674/assessment-of-hydrogels-for-bioprinting-of-endothelial-cells
#7
Leo Benning, Ludwig Gutzweiler, Kevin Tröndle, Julian Riba, Roland Zengerle, Peter Koltay, Stefan Zimmermann, G Björn Stark, Günter Finkenzeller
In tissue engineering applications, vascularization can be accomplished by co-implantation of tissue forming cells and endothelial cells (ECs), whereby the latter are able to form functional blood vessels. The use of three-dimensional (3D) bioprinting technologies has the potential to improve the classical tissue engineering approach because these will allow the generation of scaffolds with high spatial control of endothelial cell allocation. This study focuses on a side by side comparisons of popular commercially available bioprinting hydrogels (matrigel, fibrin, collagen, gelatin, agarose, Pluronic F-127, alginate and alginate/gelatin) in the context of their physicochemical parameters, their swelling/degradation characteristics, their biological effects on vasculogenesis-related EC parameters and their printability...
November 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29111891/regenerative-medicine-in-india-trends-and-challenges-in-innovation-and-regulation
#8
Shashank S Tiwari, Sujatha Raman, Paul Martin
The government of India has heavily promoted research and development in regenerative medicine together with domestic innovation and business development initiatives. Together, these promise a revolution in healthcare and public empowerment in India. Several national and transnational linkages have emerged to develop innovative capacity, most prominently in stem cell and cord blood banking, as well as in gene therapy, tissue engineering, biomaterials and 3D printing. However, challenges remain of achieving regulatory oversight, viable outputs and equitable impacts...
November 7, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29106911/stem-cells-niches-and-scaffolds-applications-to-burns-and-wound-care
#9
Suzanne M Watt, Jonathan M Pleat
The importance of skin to survival, and the devastating physical and psychological consequences of scarring following reparative healing of extensive or difficult to heal human wounds, cannot be disputed. We discuss the significant challenges faced by patients and healthcare providers alike in treating these wounds. New state of the art technologies have provided remarkable insights into the role of skin stem and progenitor cells and their niches in maintaining skin homeostasis and in reparative wound healing...
October 26, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29106065/fast-setting-silk-fibroin-bioink-for-bioprinting-of-patient-specific-memory-shape-implants
#10
João B Costa, Joana Silva-Correia, Joaquim M Oliveira, Rui L Reis
The pursuit for the "perfect" biomimetic and personalized implant for musculoskeletal tissue regeneration remains a big challenge. 3D printing technology that makes use of a novel and promising biomaterials can be part of the solution. In this study, a fast setting enzymatic-crosslinked silk fibroin (SF) bioink for 3D bioprinting is developed. Their properties are fine-tuned and different structures with good resolution, reproducibility, and reliability can be fabricated. Many potential applications exist for the SF bioinks including 3D bioprinted scaffolds and patient-specific implants exhibiting unique characteristics such as good mechanical properties, memory-shape feature, suitable degradation, and tunable pore architecture and morphology...
November 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29102798/three-dimensional-fabrication-of-thick-and-densely-populated-soft-constructs-with-complex-and-actively-perfused-channel-network
#11
C Rodrigo Pimentel, Suk Kyu Ko, Claudia Caviglia, Anders Wolff, Jenny Emnéus, Stephan Sylvest Keller, Martin Dufva
One of the fundamental steps needed to design functional tissues and, ultimately organs is the ability to fabricate thick and densely populated tissue constructs with controlled vasculature and microenvironment. To date, bioprinting methods have been employed to manufacture tissue constructs with open vasculature in a square-lattice geometry, where the majority lacks the ability to be directly perfused. Moreover, it appears to be difficult to fabricate vascular tissue constructs targeting the stiffness soft tissues such as the liver...
November 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29097309/emerging-tumor-spheroids-technologies-for-3d-in-vitro-cancer-modeling
#12
REVIEW
Tânia Rodrigues, Banani Kundu, Joana Silva-Correia, S C Kundu, Joaquim M Oliveira, Rui L Reis, Vitor M Correlo
Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are caused by metastasis and just 10% by primary tumor. The advancement of treatment approaches is not at the same rhythm of the disease; making cancer a focal target of biomedical research. To enhance the understanding and promts the therapeutic delivery; concepts of tissue engineering are applied in the development of in vitro models that can bridge between 2D cell culture and animal models, mimicking tissue microenvironment...
October 30, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29091678/femtosecond-versus-picosecond-laser-pulses-for-film-free-laser-bioprinting
#13
Stephane Petit, Olivia Kérourédan, Raphael Devillard, Eric Cormier
We investigate the properties of microjets in the context of film-free laser induced forward transfer in the femtosecond and picosecond regimes. The influence of the pulse duration (ranging from 0.4 to 12 ps) and the energy (ranging from 6 to 12 μJ) is systematically studied on the height, diameter, speed, volume, and shape of the jets. The 400 fs pulses generate thin and stable jets compatible with bioprinting, while 14 ps pulses generate more unstable jets. A pulse duration around 8 ps seems, therefore, to be an interesting trade-off to cover many bio-applications of microjets generated by lasers...
November 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29091482/image-once-print-thrice-three-dimensional-printing-of-replacement-parts
#14
Timothy M Rankin, Blair A Wormer, John D Miller, Nicholas A Giovinco, Salam Al Kassis, David G Armstrong
OBJECTIVE: The last 20 years has seen an exponential increase in 3D printing as it pertains to the medical industry and more specifically surgery. Previous reviews in this domain have chosen to focus on applications within a specific field. To our knowledge none have evaluated the broad applications of patient-specific or Digital Imaging and Communications in Medicine (DICOM) derived applications of this technology. METHODS: We searched PUBMED and CINAHL from April 2012 up to April 2017...
November 1, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29090210/four-dimensional-bioprinting-as-a-new-era-for-tissue-engineering-and-regenerative-medicine
#15
Pedro Morouço, Wanda Lattanzi, Nuno Alves
No abstract text is available yet for this article.
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29083312/bioprinted-chitosan-gelatin-thermosensitive-hydrogels-using-an-inexpensive-3d-printer
#16
Kevin D Roehm, Sundararajan V Madihally
The primary bottleneck in bioprinting cell-laden structures with carefully controlled spatial relation is a lack of biocompatible inks and printing conditions. In this regard, we explored using thermogelling chitosan-gelatin (CG) hydrogel as a novel bioprinting ink; CG hydrogels is unique in that it undergoes a spontaneous phase change at physiological temperature, and does not need post-processing. In addition, we used a low cost (<$800) compact 3D printer, and modified with a new extruder to print using disposable syringes and hypodermic needles...
October 30, 2017: Biofabrication
https://www.readbyqxmd.com/read/29081051/bioprinting-and-biofabrication-with-peptide-and-protein-biomaterials
#17
Mitchell Boyd-Moss, Kate Fox, Milan Brandt, David Nisbet, Richard Williams
The ability to fabricate artificial tissue constructs through the controlled organisation of cells, structures and signals within a biomimetic scaffold offers significant promise to the field of regenerative medicine, drug delivery and tissue engineering. Advances in additive manufacturing technologies have facilitated the printing of spatially defined cell-laden artificial tissue constructs capable of providing biomimetic spatiotemporal presentation of biological and physical cues to cells in a designed multicomponent structure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29080923/treatment-of-critical-sized-bone-defects-clinical-and-tissue-engineering-perspectives
#18
REVIEW
Erika Roddy, Malcolm R DeBaun, Adam Daoud-Gray, Yunzhi P Yang, Michael J Gardner
Critical-sized bone defects are defined as those that will not heal spontaneously within a patient's lifetime. Current treatment options include vascularized bone grafts, distraction osteogenesis, and the induced membrane technique. The induced membrane technique is an increasingly utilized method with favorable results including high rates of union. Tissue engineering holds promise in the treatment of large bone defects due to advancement of stem cell biology, novel biomaterials, and 3D bioprinting. In this review, we provide an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects...
October 28, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29074999/in-vivo-and-ex-vivo-methods-of-growing-a-liver-bud-through-tissue-connection
#19
Yusuke Yanagi, Koichi Nakayama, Tomoaki Taguchi, Shin Enosawa, Tadashi Tamura, Koichiro Yoshimaru, Toshiharu Matsuura, Makoto Hayashida, Kenichi Kohashi, Yoshinao Oda, Takayoshi Yamaza, Eiji Kobayashi
Cell-based therapy has been proposed as an alternative to orthotopic liver transplantation. The novel transplantation of an in vitro-generated liver bud might have therapeutic potential. In vivo and ex vivo methods for growing a liver bud are essential for paving the way for the clinical translation of liver bud transplantation. We herein report a novel transplantation method for liver buds that are grown in vivo involving orthotopic transplantation on the transected parenchyma of the liver, which showed long engraftment and marked growth in comparison to heterotopic transplantation...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29060188/visible-light-based-stereolithography-bioprinting-of-cell-adhesive-gelatin-hydrogels
#20
Zongjie Wang, Zhenlin Tian, Xian Jin, Jonathan F Holzman, Frederic Menard, Keekyoung Kim
Stereolithography-based bioprinting offers advantages in resolution and rapid printing time, and thus has received major attention in recent years. However, traditional stereolithography-based bioprinting utilizes an ultraviolet light which may cause mutagenesis and carcinogenesis of cells. In this paper, we present a new visible light crosslinkable bioink that is based on cell-adhesive gelatin. The bioink consists of Eosin Y (EY) based photoinitiator and gelatin methacrylate (GelMA) pre-polymer solution. We examined the feasibility of using visible light from a commercial beam projector to pattern the EY-GelMA bioink...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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