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Bioprinting

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https://www.readbyqxmd.com/read/28429072/kidney-development-and-perspectives-for-organ-engineering
#1
REVIEW
Ganna Reint, Aleksandra Rak-Raszewska, Seppo J Vainio
Organ transplantation is currently the best strategy for treating end stage renal disease (ESRD) but the numbers of donor kidneys available are not sufficient to meet the needs of the ever-increasing ESRD population. Therefore, developments in the field of tissue engineering are necessary to provide alternative treatments. Decellularization and three-dimensional (3D) bioprinting strategies may serve as attractive novel options. Since successful tissue engineering requires an in -depth understanding of organ development and regulatory pathways, we discuss signaling in renal development and the composition of the renal extracellular matrix before presenting progress in the decellularization and 3D bioprinting fields...
April 20, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28424770/recent-advances-in-bioink-design-for-3d-bioprinting-of-tissues-and-organs
#2
REVIEW
Shen Ji, Murat Guvendiren
There is a growing demand for alternative fabrication approaches to develop tissues and organs as conventional techniques are not capable of fabricating constructs with required structural, mechanical, and biological complexity. 3D bioprinting offers great potential to fabricate highly complex constructs with precise control of structure, mechanics, and biological matter [i.e., cells and extracellular matrix (ECM) components]. 3D bioprinting is an additive manufacturing approach that utilizes a "bioink" to fabricate devices and scaffolds in a layer-by-layer manner...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28416222/dentin-on-the-nanoscale-hierarchical-organization-mechanical-behavior-and-bioinspired-engineering
#3
REVIEW
Luiz E Bertassoni
OBJECTIVE: Knowledge of the structural organization and mechanical properties of dentin has expanded considerably during the past two decades, especially on a nanometer scale. In this paper, we review the recent literature on the nanostructural and nanomechanical properties of dentin, with special emphasis in its hierarchical organization. METHODS: We give particular attention to the recent literature concerning the structural and mechanical influence of collagen intrafibrillar and extrafibrillar mineral in healthy and remineralized tissues...
April 14, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28412784/-three-dimensional-printing-and-oral-medicine
#4
M Hu
After 30 years of development, three-dimensional printing technology has made great progress, and the model and surgical guide have been clinically applied. The three-dimensional printing of titanium and other metal prosthesis and dental crown after adequate research will be applied clinically, and three-dimensional bioprinting and related biological materials need further study. Three-dimensional printing provides opportunities for the development of oral medicine, which will change the way of clinical work, teaching and research...
April 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28388499/microfluidic-enhanced-3d-bioprinting-of-aligned-myoblast-laden-hydrogels-leads-to-functionally-organized-myofibers-in%C3%A2-vitro-and-in%C3%A2-vivo
#5
Marco Costantini, Stefano Testa, Pamela Mozetic, Andrea Barbetta, Claudia Fuoco, Ersilia Fornetti, Francesco Tamiro, Sergio Bernardini, Jakub Jaroszewicz, Wojciech Święszkowski, Marcella Trombetta, Luisa Castagnoli, Dror Seliktar, Piotr Garstecki, Gianni Cesareni, Stefano Cannata, Alberto Rainer, Cesare Gargioli
We present a new strategy for the fabrication of artificial skeletal muscle tissue with functional morphologies based on an innovative 3D bioprinting approach. The methodology is based on a microfluidic printing head coupled to a co-axial needle extruder for high-resolution 3D bioprinting of hydrogel fibers laden with muscle precursor cells (C2C12). To promote myogenic differentiation, we formulated a tailored bioink with a photocurable semi-synthetic biopolymer (PEG-Fibrinogen) encapsulating cells into 3D constructs composed of aligned hydrogel fibers...
March 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28386058/cartilage-tissue-engineering-by-the-3d-bioprinting-of-ips-cells-in-a-nanocellulose-alginate-bioink
#6
Duong Nguyen, Daniel A Hägg, Alma Forsman, Josefine Ekholm, Puwapong Nimkingratana, Camilla Brantsing, Theodoros Kalogeropoulos, Samantha Zaunz, Sebastian Concaro, Mats Brittberg, Anders Lindahl, Paul Gatenholm, Annika Enejder, Stina Simonsson
Cartilage lesions can progress into secondary osteoarthritis and cause severe clinical problems in numerous patients. As a prospective treatment of such lesions, human-derived induced pluripotent stem cells (iPSCs) were shown to be 3D bioprinted into cartilage mimics using a nanofibrillated cellulose (NFC) composite bioink when co-printed with irradiated human chondrocytes. Two bioinks were investigated: NFC with alginate (NFC/A) or hyaluronic acid (NFC/HA). Low proliferation and phenotypic changes away from pluripotency were seen in the case of NFC/HA...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28382922/laser-direct-write-based-fabrication-of-a-spatially-defined-biomimetic-construct-as-a-potential-model-for-breast-cancer-cell-invasion-into-adipose-tissue
#7
Benjamin Tyler Vinson, Theresa Phamduy, Josh Shipman, Brian Riggs, Amy Strong, Walter Murfee, Matthew Burow, Bruce Bunnell, Samuel Sklare, Yong Huang, Douglas Chrisey
Epithelial-adipose interaction is an integral step in breast cancer cell invasion and progression towards lethal metastatic disease.  Understanding the physiological contribution of obesity, a major contributor to breast cancer risk and negative prognosis in post-menopausal patients, on cancer cell invasion requires detailed co-culture constructs that reflect mammary microarchitecture.  Using laser direct-write, a laser-based CAD/CAM bioprinting technique, we have demonstrated the ability to construct breast cancer cell-laden hydrogel microbeads into spatially defined patterns in hydrogel matrices containing differentiated adipocytes...
April 6, 2017: Biofabrication
https://www.readbyqxmd.com/read/28374411/a-perspective-on-bioprinting-ethics
#8
Sanjairaj Vijayavenkataraman
No abstract text is available yet for this article.
November 2016: Artificial Organs
https://www.readbyqxmd.com/read/28373522/three-dimensional-bioprinting-emerging-technology-in-cardiovascular-medicine
#9
Kurosh Ameri, Raffi Samurkashian, Yerem Yeghiazarians
No abstract text is available yet for this article.
April 4, 2017: Circulation
https://www.readbyqxmd.com/read/28372274/stem-cell-roadmap%C3%A2-the-industrial-point-of%C3%A2-view
#10
Mazen Elzaabi, Agnès Thevenin, Pierre-Noël Lirsac
CELLforCURE is a French Contract Development and Manufacturing Organization (CDMO) dedicated to industrialization and process development for routine manufacturing, GMP manufacturing for clinical and commercial batches and regulatory services and associated logistics. CELLforCURE is a subsidiary of LFB Group.Stem cells fields of application gather cell and gene therapy as well as tissue engineering. According to VisionGain survey, cell therapy medicinal products will remain predominant in the future.Clinical trials are sponsored either by universities or private companies...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28370405/emerging-biofabrication-strategies-for-engineering-complex-tissue-constructs
#11
REVIEW
R Daniel Pedde, Bahram Mirani, Ali Navaei, Tara Styan, Sarah Wong, Mehdi Mehrali, Ashish Thakur, Nima Khadem Mohtaram, Armin Bayati, Alireza Dolatshahi-Pirouz, Mehdi Nikkhah, Stephanie M Willerth, Mohsen Akbari
The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long-term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing patient-derived cells in biomaterial scaffolds in the presence of pertinent physicochemical signals, provides a promising solution to meet this demand. However, recapitulating the structural and cytoarchitectural complexities of native tissues in vitro remains a significant challenge to be addressed...
April 3, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28351222/bone-regenerative-medicine-in-oral-and-maxillofacial-region-using-a-3d-printer
#12
Atsuhiko Hikita, Ung-Il Chung, Kazuto Hoshi, Tsuyoshi Takato
Bone grafts currently used for the treatment of large bone defect or asymmetry in oral and maxillofacial region include autologous, allogenic and artificial bones. Although artificial bone is free from the concerns of donor site morbidity, limitation of volume, disease transmission and ethical issues, it lacks osteogenic and osteoinductive activities. In addition, molding of the artificial bone is an issue especially when it is used for the augmentation of bone as onlay grafts. To solve this problem, additive manufacturing techniques have been applied to fabricate bones which have outer shapes conformed to patients' bones...
March 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28337147/3d-proximal-tubule-tissues-recapitulate-key-aspects-of-renal-physiology-to-enable-nephrotoxicity-testing
#13
Shelby M King, J William Higgins, Celina R Nino, Timothy R Smith, Elizabeth H Paffenroth, Casey E Fairbairn, Abigail Docuyanan, Vishal D Shah, Alice E Chen, Sharon C Presnell, Deborah G Nguyen
Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a primary site of nephrotoxicity and resulting attrition in the drug development pipeline. Current pre-clinical methods using 2D cell cultures and animal models are unable to fully recapitulate clinical drug responses due to limited in vitro functional lifespan, or species-specific differences. Using Organovo's proprietary 3D bioprinting platform, we have developed a fully cellular human in vitro model of the proximal tubule interstitial interface comprising renal fibroblasts, endothelial cells, and primary human renal proximal tubule epithelial cells to enable more accurate prediction of tissue-level clinical outcomes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28333087/magnetically-bioprinted-human-myometrial-3d-cell-rings-as-a-model-for-uterine-contractility
#14
Glauco R Souza, Hubert Tseng, Jacob A Gage, Arunmani Mani, Pujan Desai, Fransisca Leonard, Angela Liao, Monica Longo, Jerrie S Refuerzo, Biana Godin
Deregulation in uterine contractility can cause common pathological disorders of the female reproductive system, including preterm labor, infertility, inappropriate implantation, and irregular menstrual cycle. A better understanding of human myometrium contractility is essential to designing and testing interventions for these important clinical problems. Robust studies on the physiology of human uterine contractions require in vitro models, utilizing a human source. Importantly, uterine contractility is a three-dimensionally (3D)-coordinated phenomenon and should be studied in a 3D environment...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28323412/temporary-single-cell-coating-for-bioprocessing-with-a-cationic-polymer
#15
Ricardo D C Ribeiro, Deepali Pal, David Jamieson, Kenneth S Rankin, Matthew Benning, Kenneth W Dalgarno, Ana M Ferreira
Temporary single-cell coating is a useful tool for cell processing, allowing manipulation of cells to prevent cell attachment and agglomeration, before re-establishing normal cell function. In this work, a speckled coating method using a known polycation [poly(l-lysine), PLL] is described to induce cell surface electrostatic charges on three different cell types, namely, two bone cancer cell lines and fibroblasts. The morphology of the PLL speckled coating on the cell surface, internalization and metabolization of the polymer, and prevention of cellular aggregations are reported...
April 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28320774/3d-bioprint-me-a-socioethical-view-of-bioprinting-human-organs-and-tissues
#16
Niki Vermeulen, Gill Haddow, Tirion Seymour, Alan Faulkner-Jones, Wenmiao Shu
In this article, we review the extant social science and ethical literature on three-dimensional (3D) bioprinting. 3D bioprinting has the potential to be a 'game-changer', printing human organs on demand, no longer necessitating the need for living or deceased human donation or animal transplantation. Although the technology is not yet at the level required to bioprint an entire organ, 3D bioprinting may have a variety of other mid-term and short-term benefits that also have positive ethical consequences, for example, creating alternatives to animal testing, filling a therapeutic need for minors and avoiding species boundary crossing...
March 20, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28314117/three-dimensional-cell-cultures-in-drug-discovery-and-development
#17
Ye Fang, Richard M Eglen
The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease. In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. We also discuss the implementation of these technologies in compound identification, screening, and development, ranging from disease modeling to assessment of efficacy and safety profiles...
March 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28289247/three-dimensional-bioprinting-strategies-for-tissue-engineering
#18
Yu Shrike Zhang, Rahmi Oklu, Mehmet Remzi Dokmeci, Ali Khademhosseini
Over the past decades, many approaches have been developed to fabricate biomimetic extracellular matrices of desired properties for engineering functional tissues. However, the inability of these techniques to precisely control the spatial architecture has posed a significant challenge in producing complex tissues. 3D bioprinting technology has emerged as a potential solution by bringing unprecedented freedom and versatility in depositing biological materials and cells in a well-controlled manner in the 3D volumes, therefore achieving precision engineering of functional tissues...
March 13, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28280669/in-vivo-chondrogenesis-in-3d-bioprinted-human-cell-laden-hydrogel-constructs
#19
Thomas Möller, Matteo Amoroso, Daniel Hägg, Camilla Brantsing, Nicole Rotter, Peter Apelgren, Anders Lindahl, Lars Kölby, Paul Gatenholm
BACKGROUND: The three-dimensional (3D) bioprinting technology allows creation of 3D constructs in a layer-by-layer fashion utilizing biologically relevant materials such as biopolymers and cells. The aim of this study is to investigate the use of 3D bioprinting in a clinically relevant setting to evaluate the potential of this technique for in vivo chondrogenesis. METHODS: Thirty-six nude mice (Balb-C, female) received a 5- × 5- × 1-mm piece of bioprinted cell-laden nanofibrillated cellulose/alginate construct in a subcutaneous pocket...
February 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28269205/gelatin-methacrylamide-hydrogel-with-graphene-nanoplatelets-for-neural-cell-laden-3d-bioprinting
#20
Wei Zhu, Brent T Harris, Lijie Grace Zhang
Nervous system is extremely complex which leads to rare regrowth of nerves once injury or disease occurs. Advanced 3D bioprinting strategy, which could simultaneously deposit biocompatible materials, cells and supporting components in a layer-by-layer manner, may be a promising solution to address neural damages. Here we presented a printable nano-bioink composed of gelatin methacrylamide (GelMA), neural stem cells, and bioactive graphene nanoplatelets to target nerve tissue regeneration in the assist of stereolithography based 3D bioprinting technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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