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https://www.readbyqxmd.com/read/29334194/enrollment-in-early-phase-clinical-trials-in-pediatric-oncology-the-experience-at-institut-curie
#1
Aurore Surun, Marie-Églantine Dujaric, Isabelle Aerts, Daniel Orbach, Irène Jiménez, Hélène Pacquement, Gudrun Schleiermacher, Franck Bourdeaut, Jean Michon, Jean-Claude K Dupont, François Doz
BACKGROUND: The European Paediatric Regulation was introduced in 2007 to facilitate access to new medicines for children. Our study explored accessibility of early-phase trials in pediatric oncology, in line with the European Paediatric Regulation, to identify the reasons for not inviting patients to participate, parents' refusal, or inclusion failure. PROCEDURE: We conducted a retrospective chart review at Institut Curie, Paris, for all pediatric patients whose cancer progressed despite known effective treatments between July 2010 and December 2013...
January 15, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29333802/an-upgraded-model-of-teaching-physical-and-rehabilitation-medicine-the-vertical-education-approach-of-split-university-croatia
#2
Tonko Vlak, Saša Moslavac, Ana Poljičanin, Jure Aljinović, Igor Barišić, Maria G Ceravolo
No abstract text is available yet for this article.
January 11, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29333463/characteristics-of-smoothing-filters-to-achieve-the-guideline-recommended-positron-emission-tomography-image-without-harmonization
#3
Yuji Tsutsui, Shinichi Awamoto, Kazuhiko Himuro, Yoshiyuki Umezu, Shingo Baba, Masayuki Sasaki
Objectives: The aim of this study is to examine the effect of different smoothing filters on the image quality and SUVmax to achieve the guideline recommended positron emission tomography (PET) image without harmonization. Methods: We used a Biograph mCT PET scanner. A National Electrical Manufacturers Association (NEMA) the International Electrotechnical Commission (IEC) body phantom was filled with 18F solution with a background activity of 2.65 kBq/mL and a sphere-to-background ratio of 4...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333278/clinical-influence-of-exercise-therapy-on-sarcopenia-in-patients-with-chronic-pancreatitis-a-study-protocol-for-a-randomised-controlled-trial
#4
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Chronic pancreatitis (CP) involves progressive inflammatory changes to the pancreas and can lead to permanent structural damage and impairment of both endocrine and exocrine functions. Current reports highlight a rise in the incidence and prevalence of CP. However, there is limited data currently available concerning patients with CP undergoing exercise therapy (ET). We aim to prospectively examine the influence of ET on sarcopenia in patients with CP. Methods and analysis: A detailed evaluation of the nutritional condition and the daily physical activities of each participant will be conducted prior to entering the study...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29332733/a-fundamental-critique-of-the-fascial-distortion-model-and-its-application-in-clinical-practice
#5
Christoph Thalhamer
INTRODUCTION: The therapeutic techniques used in the fascial distortion model (FDM) have become increasingly popular among manual therapists and physical therapists. The reasons for this trend remain to be empirically explored. Therefore this paper pursues two goals: first, to investigate the historical and theoretical background of FDM, and second, to discuss seven problems associated with the theory and practice of FDM. MATERIALS AND METHODS: The objectives of this paper are based on a review of the literature...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332500/microstructure-and-mechanical-properties-of-porous-titanium-structures-fabricated-by-electron-beam-melting-for-cranial-implants
#6
Khaja Moiduddin
The traditional methods of metallic bone implants are often dense and suffer from adverse reactions, biomechanical mismatch and lack of adequate space for new bone tissue to grow into the implant. The objective of this study is to evaluate the customized porous cranial implant with mechanical properties closer to that of bone and to improve the aesthetic outcome in cranial surgery with precision fitting for a better quality of life. Two custom cranial implants (bulk and porous) are digitally designed based on the Digital Imaging and Communications in Medicine files and fabricated using additive manufacturing...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29332412/-investigation-of-the-burnout-syndrome-among-the-employees-of-the-department-of-emergency-medicine-at-the-university-of-szeged
#7
Emőke Adrienn Hompoth, Annamária Töreki, Zoltán Pető
INTRODUCTION: Burnout has been described as a growing problem amongst healthcare workers. Emergency department staffs experience the burden of stress day by day, yet only a few studies have examined their burnout. AIM: In this study we wanted to investigate the burnout and its relations to other variables amongst the employees of the Department of Emergency Medicine in Szeged. METHOD: Cross-sectional design utilizing a self-administered questionnaire was used to collect data from the staff of the Department...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29331536/chronic-inflammation-and-sarcopenia-a-regenerative-cell-therapy-perspective
#8
Jagadish K Chhetri, Philipe de Souto Barreto, Bertrand Fougère, Yves Rolland, Bruno Vellas, Matteo Cesari
Sarcopenia is characterized by reduced skeletal muscle mass and strength in older individuals. It is one of the leading cause of physical limitation in older adults, and associated with wide spectrum of adverse events including disability and mortality. The phenomenon of chronic-inflammation or inflamm-aging with aging is known to be a major contributor to myriad of geriatric conditions including sarcopenia. Recent advances in regenerative medicine, in particular cell therapy have opened up new possibilities to ameliorate broad range of inflammatory disorders...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#9
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330175/development-and-validation-of-an-instrument-for-measuring-the-burden-of-medicine-on-functioning-and-well-being-the-medication-related-burden-quality-of-life-mrb-qol-tool
#10
Mohammed A Mohammed, Rebekah J Moles, Sarah N Hilmer, Lisa Kouladjian O'Donnel, Timothy F Chen
OBJECTIVE: Medication-related burden (MRB) is a negative experience with medicine, which may impact on psychological, social, physical and financial well-being of an individual. This study describes the development and initial validation of an instrument specifically designed to measure MRB on functioning and well-being-the Medication-Related Burden Quality of Life (MRB-QoL) tool. METHODS: An initial pool of 76-items for MRB-QoL was generated. The link to MRB-QoL survey was sent to a sample of consumers living with at least one chronic medical condition and taking ≥3 prescription medicines on a regular basis...
January 11, 2018: BMJ Open
https://www.readbyqxmd.com/read/29329463/ginsenoside-rh1-a-systematic-review-of-its-pharmacological-properties
#11
Dao Ngoc Hien Tam, Duy Hieu Truong, Thi Thanh Hoa Nguyen, Le Nhat Quynh, Linh Tran, Hong Duong Nguyen, Bahaa Eldin Shamandy, Thi Minh Huong Le, Dang Khoa Tran, Dina Sayed, Van Vinh Vu, Shusaku Mizukami, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design...
January 12, 2018: Planta Medica
https://www.readbyqxmd.com/read/29328718/charge-catastrophe-and-dielectric-breakdown-during-exposure-of-organic-thin-films-to-low-energy-electron-radiation
#12
A Thete, D Geelen, S J van der Molen, R M Tromp
The effects of exposure to ionizing radiation are central in many areas of science and technology, including medicine and biology. Absorption of UV and soft-x-ray photons releases photoelectrons, followed by a cascade of lower energy secondary electrons with energies down to 0 eV. While these low energy electrons give rise to most chemical and physical changes, their interactions with soft materials are not well studied or understood. Here, we use a low energy electron microscope to expose thin organic resist films to electrons in the range 0-50 eV, and to analyze the energy distribution of electrons returned to the vacuum...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328042/dynamics-of-changes-in-indices-of-endogenous-intoxication-in-patients-with-acute-small-intestinal-obstruction-in-case-of-reamberin-use-in-the-comprehensive-treatment
#13
V Skrypko, A Kovalenko, E Talikova
The objective of this research was to study changes in parameters, characterizing endogenous intoxication in patients with acute small bowel obstruction with Reamberin included into therapy scheme. Full physical examination and surgical treatment of 202 patients with acute small bowel obstruction were conducted. The control group included 30 healthy individuals. Dynamics of such clinical biochemical parameters as medium mass molecules (MMM), malondialdehyde (MDA), diene conjugates (DC) in blood serum were analyzed in preoperative period and on the 1st, 5th and 14th day of postoperative period...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29326418/a-case-of-right-sided-direct-carotid-cavernous-fistula-a-diagnostic-challenge
#14
Htun Latt, Kyaw Kyaw, Htwe Htwe Yin, Deepak Kapoor, Sammy San Myint Aung, Raheel Islam
BACKGROUND Carotid cavernous fistulas (CCFs) are rare potentially sight-threatening abnormal connections between carotid artery and cavernous sinus. CASE REPORT We report a case of CCF in an 83-year-old female, who presented with swollen and painful right eye. The patient was initially treated with empiric antibiotics for suspected peri-orbital cellulitis, as noted clinically and in computed tomography (CT) orbits. However, lack of clinical improvement, physical finding of orbital bruit/thrill, and enlarged superior ophthalmic vein in magnetic resonance (MR) orbits suggest alternate diagnoses...
January 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29325162/an-analysis-of-adverse-events-in-the-rehabilitation-department-using-the-veterans-affairs-root-cause-analysis-system
#15
Gregory W Hagley, Peter D Mills, Brian Shiner, Robin R Hemphill
Background: Root cause analyses (RCA) are often completed in health care settings to determine causes of adverse events (AEs). RCAs result in action plans designed to mitigate future patient harm. National reviews of RCA reports have assessed the safety of numerous health care settings and suggested opportunities for improvement. However, few studies have assessed the safety of receiving care from physical therapists, occupational therapists, or speech and language pathology pathologists...
January 9, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29324048/peer-observation-of-rounds-leads-to-collegial-discussion-of-teaching
#16
J Rush Pierce, Patrick Rendón, Deepti Rao
PROBLEM: Faculty in the Division of Hospital Medicine provide most of the clinical teaching for learners at our institution. The majority of these faculty are Assistant Professors with limited formal instruction in clinical teaching. Previous Divisional strategies to improve clinical teaching ability included discussion of effective teaching behaviors, developing written expectations for teaching faculty, and instituting seminars on effective clinical teaching. Heretofore, the Division had not utilized a direct observation exercise...
January 11, 2018: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29322473/pharmaceutical-care-and-health-related-quality-of-life-outcomes-over-the-past-25%C3%A2-years-have-we-measured-dimensions-that-really-matter
#17
REVIEW
Mohammed A Mohammed, Rebekah J Moles, Timothy F Chen
Background Several measures of Health-Related Quality of Life (HRQoL) have been used to evaluate Pharmaceutical Care (PC) interventions in the past decades. However, their suitability for evaluation of PC services has not been comprehensively evaluated. Aim of the review The aim of this review was to perform content analysis of HRQoL measures used in PC studies to gain an insight into their suitability for evaluation of PC services. Method PC studies evaluating HRQoL as a primary or secondary outcomes were retrieved based on a literature search of articles published from 1990 to 2015, on Medline, Embase, International Pharmaceutical Abstracts, Global Health, PsycInfo, Web of Science, Cinahl, HealthStar, Cochrane Library, AUSThealth, Australian Medical Index, and Current content...
January 10, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29321123/comparative-analysis-of-women-with-notable-subjective-health-indicators-compared-with-participants-in-the-australian-longitudinal-study-on-women-s-health-cross-sectional-survey
#18
Christoph Schnelle, Eunice J Minford, Vanessa McHardy, Jane Keep
BACKGROUND: At least six communities with unusually good health and longevity have been identified, but their lifestyles aren't adopted widely. Informal evidence suggests that women associated with Universal Medicine (UM), a complementary medicine health care organization in Eastern Australia and the United Kingdom with normal lifestyles, also have several unusual health indicators. OBJECTIVE: Our objective was to determine how UM participants compared with women in the Australian population at large on a variety of health indicators...
January 10, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29320509/dynamics-of-co-authorship-and-productivity-across-different-fields-of-scientific-research
#19
Austin J Parish, Kevin W Boyack, John P A Ioannidis
We aimed to assess which factors correlate with collaborative behavior and whether such behavior associates with scientific impact (citations and becoming a principal investigator). We used the R index which is defined for each author as log(Np)/log(I1), where I1 is the number of co-authors who appear in at least I1 papers written by that author and Np are his/her total papers. Higher R means lower collaborative behavior, i.e. not working much with others, or not collaborating repeatedly with the same co-authors...
2018: PloS One
https://www.readbyqxmd.com/read/29319376/the-effect-of-physical-activity-on-ptsd
#20
Lauren M Oppizzi, Reba Umberger
Although physical activity (PA) is known to reduce anxiety and depression, less is known about the effects of PA on post-traumatic stress disorder (PTSD). The author examined the state of the science regarding the effect of PA on PTSD. Three themes emerged: PA characteristics, added benefits of PA as a PTSD intervention, and theories on the method of action. Physical activity seems to be an effective adjunct therapy to reduce PTSD symptom severity. Findings are inconsistent between observational and controlled studies...
January 10, 2018: Issues in Mental Health Nursing
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