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https://www.readbyqxmd.com/read/28717659/identification-and-characterization-of-variants-and-a-novel-4%C3%A2-bp-deletion-in-the-regulatory-region-of-six6-a-risk-factor-for-primary-open-angle-glaucoma
#1
Mohd Hussain Shah, Noemi Tabanera, Subbaiah Ramasamy Krishnadas, Manju R Pillai, Paola Bovolenta, Periasamy Sundaresan
BACKGROUND: Primary open-angle glaucoma (POAG) is a complex disease of multigenic inheritance and the most common subtype of glaucoma. SIX6 encodes a transcription factor involved in retina, optic nerve, and pituitary development. Previous studies showed a genetic association between the SIX6 locus and POAG, identifying risk alleles. Whether these alleles are present also in the south Indian population is unclear. METHODS: To address this question, the SIX6 gene and an already characterized and highly conserved SIX6 enhancer (Ch14:60974427-60974430) were sequenced in two south Indian cohorts, respectively, composed of 65/65 and 200/200 POAG cases/age-matched controls...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28716690/does-player-time-in-game-affect-tackle-technique-in-elite-level-rugby-union
#2
Gregory J Tierney, Karl Denvir, Garreth Farrell, Ciaran K Simms
OBJECTIVES: It has been hypothesised that fatigue may be a major factor in tackle-related injury risk in rugby union and hence more injuries occur in the later stages of a game. The aim of this study is to identify changes in ball carrier or tackler proficiency characteristics, using elite level match video data, as player time-in-game increases. DESIGN: Qualitative observational cohort study. METHODS: Three 2014/15 European Rugby Champions Cup games were selected for ball carrier and tackler proficiency analysis...
July 4, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28716611/predictability-of-action-sub-steps-modulates-motor-system-activation-during-the-observation-of-goal-directed-actions
#3
Ricarda Braukmann, Harold Bekkering, Margreeth Hidding, Edita Poljac, Jan K Buitelaar, Sabine Hunnius
Action perception and execution are linked in the human motor system, and researchers have proposed that this action-observation matching system underlies our ability to predict observed behavior. If the motor system is indeed involved in the generation of action predictions, activation should be modulated by the degree of predictability of an observed action. This study used EEG and eye-tracking to investigate whether and how predictability of an observed action modulates motor system activation as well as behavioral predictions in the form of anticipatory eye-movements...
July 14, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28712802/efficacy-of-a-pelvic-lateral-positioner-with-a-mechanical-cup-navigator-based-on-the-anatomical-pelvic-plane-in-total-hip-arthroplasty
#4
Kentaro Iwakiri, Akio Kobayashi, Yoichi Ohta, Yukihide Minoda, Kunio Takaoka, Hiroaki Nakamura
BACKGROUND: The acetabular component orientation in total hip arthroplasty (THA) is of critical importance to the good clinical results. However, traditional widely used cup alignment guides for cup placement are reported to be relatively unreliable. The present study aims at comparing a novel cup alignment guide, which can be attached to our anatomical pelvic plane (APP) pelvic lateral positioner for reducing discrepancies in sagittal pelvic tilt and indicate a targeted cup angle based on the APP, with a conventional cup alignment guide...
June 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28712801/the-effect-of-pelvic-tilt-and-femoral-head-size-on-hip-range-of-motion-to-impingement
#5
Thomas F McCarthy, Jim Nevelos, Randa K Elmallah, Morad Chughtai, Anton Khlopas, Vincent Alipit, Timothy C Wagner, Michael A Mont
BACKGROUND: About 50%-70% of dislocators have cups placed within so-called "safe zones." It has been postulated that factors such as femoral head size and pelvic tilt, obliquity, or rotation may influence postoperative stability. Therefore, we assessed varying degrees of pelvic tilt and head sizes on the range of motion (ROM) to impingement. METHODS: A hip simulator was used to import models of 10 subjects who performed object pickup, squatting, and low-chair rising...
June 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28712474/postherpetic-neuralgia-practical-experiences-return-to-traditional-chinese-medicine
#6
REVIEW
Majid Avijgan, Seyedeh Tahoora Hajzargarbashi, Aliasghar Kamran, Mahtab Avijgan
Post-herpetic neuralgia (PHN) is a complication of herpes zoster that can cause different types of pain in the affected area. It often occurs mainly in severe cases of herpes zoster. The problem is defined as a persisting pain for 90-120 days after relieving of acute phase of herpes lesions. This complication causes suffering in patients and reduces the quality of life. In western medicine's viewpoints, PHN is due to disturbance in local and dermatomal nerves. There are several topical and systemic drugs that are used to manage the pain relief...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28711457/comparison-of-the-finger-feeding-versus-cup-feeding-methods-in-the-transition-from-gastric-to-oral-feeding-in-preterm-infants
#7
Cláudia M D Moreira, Regina P G V Cavalcante-Silva, Cristina I Fujinaga, Francine Marson
OBJECTIVES: To assess the finger-feeding technique when compared with the cup feeding method during the early stage of preterm infant feeding transition regarding milk loss, milk ingestion period, and complications. METHODS: Experimental, randomized, prospective study including 53 preterm infants with gestation age<37 weeks, clinically stable, and with a score of >28 points in the Oral Feeding Readiness Assessment Scale. The preterm babies were randomized to be included in the control group, which underwent the feeding transition using a cup or in the experimental group, which used the finger-feeding technique...
July 13, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28711340/revision-total-hip-arthroplasty-using-the-kerboull-acetabular-reinforcement-device-and-structural-allograft-for-severe-defects-of-the-acetabulum
#8
Hiroyuki Makita, Marcel Kerboull, Yutaka Inaba, Taro Tezuka, Tomoyuki Saito, Luc Kerboull
BACKGROUND: The purpose of this study is to review our experience with Kerboull reinforcement device combined with bulk allograft for management of severe acetabular defects. METHODS: We investigated the results of revision total hip arthroplasty (THA) in 65 hips of 59 patients (10 male, 49 female) with Paprosky type 3A or 3B acetabular bone defects. Functional outcome was assessed using the Merle d'Aubigne hip score. Post-operative radiographs were examined for evidence of cup loosening...
June 23, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28709931/non-invasive-vibrometry-based-diagnostic-detection-of-acetabular-cup-loosening-in-total-hip-replacement-thr
#9
Abdullah A Alshuhri, Timothy P Holsgrove, Anthony W Miles, James L Cunningham
Total hip replacement is aimed at relieving pain and restoring function. Currently, imaging techniques are primarily used as a clinical diagnosis and follow-up method. However, these are unreliable for detecting early loosening, and this has led to the proposal of novel techniques such as vibrometry. The present study had two aims, namely, the validation of the outcomes of a previous work related to loosening detection, and the provision of a more realistic anatomical representation of the clinical scenario...
July 11, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28709898/development-of-a-duplex-taqman-real-time-pcr-assay-for-rapid-identification-of-vibrio-splendidus-related-and-v-aestuarianus-strains-from-bacterial-cultures
#10
Denis Saulnier, Sophie De Decker, Delphine Tourbiez, Marie Agnès Travers
To enable the rapid and accurate identification of Vibrio splendidus-related and V. aestuarianus strains associated with Pacific cupped oyster Crassostrea gigas mortality, we developed a duplex Taqman real-time PCR assay and evaluated its efficacy. This technique proved to be rapid, sensitive, and specific and will be particularly valuable for epidemiologic studies.
July 12, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28708201/the-impact-of-trabecular-metal-on-hip-centre-of-rotation-in-revision-and-complex-primary-hip-arthroplasty-a-radiological-review
#11
Carl O'Brien, Cillian J Keogh, Ailish Hannigan, Stephen Brennan, Cian Kennedy, Rehan Gul, James A Harty
INTRODUCTION: Total hip arthroplasty (THA) is a very successful procedure. Revision THA is becoming increasingly common. Recent developments to improve outcomes include the development of large trabecular metal (TM) acetabular cups and augments. There is a paucity of data on the benefit of these new techniques. METHODS: A single-centre retrospective review consisting of a radiological review of post-op revision THA anteroposterior pelvis. Data collection was performed using the Irish National Orthopaedic Register (INOR) and from a previous project...
July 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28708200/periacetabular-bone-densitometry-after-total-hip-arthroplasty-with-highly-porous-titanium-cups-a-2-year-follow-up-prospective-study
#12
Leo Massari, Alessandro Bistolfi, Pier Paolo Grillo, Alda Borré, Gaetano Gigliofiorito, Carlotta Pari, Andrea Francescotto, Piermario Tosco, Davide Deledda, Laura Ravera, Araldo Causero
INTRODUCTION: Trabecular Titanium is an advanced cellular solid structure, composed of regular multiplanar hexagonal interconnected cells that mimic the morphology of the trabecular bone. This biomaterial demonstrated improved mechanical properties and enhanced osteoinduction and osteoconduction in several in vitro and in vivo studies. The aim of this study was to assess Trabecular Titanium osseointegration by measuring periacetabular changes in bone mineral density (BMD) with dual-emission X-ray absorptiometry (DEXA)...
July 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28705707/gata3-as-a-valuable-marker-to-distinguish-clear-cell-papillary-renal-cell-carcinomas-from-morphologic-mimics
#13
Jose G Mantilla, Tatjana Antic, Maria Tretiakova
Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade, indolent neoplasm, with no reported cases of death from disease or metastasis. These lesions can show clinical, morphologic and immunophenotypic overlap with several aggressive forms of renal cell carcinoma (RCC), including clear cell (CCRCC), translocation RCC and papillary RCC (PRCC) with cytoplasmic clearing. Given the difference in behavior, it is important to reliably separate these entities. We retrospectively reviewed 47 tumors from 45 patients with morphologic features of CCPRCC...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28702908/water-quality-and-health-in-northern-canada-stored-drinking-water-and-acute-gastrointestinal-illness-in-labrador-inuit
#14
Carlee J Wright, Jan M Sargeant, Victoria L Edge, James D Ford, Khosrow Farahbakhsh, Inez Shiwak, Charlie Flowers, Sherilee L Harper
One of the highest self-reported incidence rates of acute gastrointestinal illness (AGI) in the global peer-reviewed literature occurs in Inuit communities in the Canadian Arctic. This high incidence of illness could be due, in part, to the consumption of contaminated water, as many northern communities face challenges related to the quality of municipal drinking water. Furthermore, many Inuit store drinking water in containers in the home, which could increase the risk of contamination between source and point-of-use (i...
July 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28702750/function-and-activity-after-minimally-invasive-total-hip-arthroplasty-compared-to-a-healthy-population
#15
Eberhard von Rottkay, Lars Rackwitz, Maximilian Rudert, Ulrich Nöth, Johannes Christian Reichert
PURPOSE: The aim of the present study was to compare the daily activity and functionality in a patient cohort 12 months after total hip arthroplasty (THA) using a direct anterior approach with a healthy non-operated control population. METHODS: Sixty-four patients who underwent THA and 59 healthy individuals (control) were assessed regarding their daily activity and joint functionality utilizing the Harris hip score (HHS), the extra short musculoskeletal functional assessment questionnaire (XSFMA), the Short Form 36 (SF-36) health survey and a Stepwatch™ Activity Monitor (SAM)...
July 12, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28702720/soft-drinks-consumption-is-associated-with-nonalcoholic-fatty-liver-disease-independent-of-metabolic-syndrome-in-chinese-population
#16
Ge Meng, Bo Zhang, Fei Yu, Chunlei Li, Qing Zhang, Li Liu, Hongmei Wu, Yang Xia, Xue Bao, Hongbin Shi, Qian Su, Yeqing Gu, Liyun Fang, Huijun Yang, Bin Yu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Huanli Jiao, Bangmao Wang, Qi Guo, Livia A Carvalhoa, Zhong Sun, Kun Song, Ming Yu, Kaijun Niu
PURPOSE: Excessive consumption of soft drinks is associated with nonalcoholic fatty liver disease (NAFLD). However, the association between soft drinks consumption and NAFLD is unclear in non-Caucasian adults with relatively low soft drinks consumption. The aim of this study was to assess the association between soft drinks consumption and NAFLD in Chinese adults. METHODS: A cross-sectional study was conducted with 26,790 adults living in Tianjin, China. NAFLD (with elevated alanine aminotransferase [ALT]) was diagnosed by the liver ultrasonography and serum ALT concentrations...
July 12, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28701563/experimental-evidence-of-human-recreational-disturbance-effects-on-bird-territory-establishment
#17
Yves Bötsch, Zulima Tablado, Lukas Jenni
The worldwide increase in human outdoor activities raises concerns for wildlife. Human disturbances, even at low levels, are likely to impact species during sensitive periods of the annual cycle. However, experimental studies during the putative sensitive period of territory establishment of birds which not only investigate low disturbance levels, but which also exclude the effect of habitat modification (e.g. walking trails) are lacking. Here, we experimentally disturbed birds in forest plots by walking through twice a day during territory establishment...
July 12, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28701521/translational-repression-of-the-drosophila-nanos-mrna-involves-the-rna-helicase-belle-and-rna-coating-by-me31b-and-trailer-hitch
#18
Michael Götze, Jérémy Dufourt, Christian Ihling, Christiane Rammelt, Stéphanie Pierson, Nagraj Sambrani, Claudia Temme, Andrea Sinz, Martine Simonelig, Elmar Wahle
Translational repression of maternal mRNAs is an essential regulatory mechanism during early embryonic development. Repression of the Drosophila nanos mRNA, required for the formation of the anterior-posterior body axis, depends on the protein Smaug binding to two Smaug recognition elements (SREs) in the nanos 3' UTR. In a comprehensive mass-spectrometric analysis of the SRE-dependent repressor complex, we identified Smaug, Cup, Me31B, Trailer hitch, eIF4E and PABPC, in agreement with earlier data. As a novel component, the RNA-dependent ATPase Belle (DDX3) was found, and its involvement in deadenylation and repression of nanos was confirmed in vivo...
July 12, 2017: RNA
https://www.readbyqxmd.com/read/28700940/in%C3%A2-vitro-modeling-using-ciliopathy-patient-derived-cells-reveals-distinct-cilia-dysfunctions-caused-by-cep290-mutations
#19
Hiroko Shimada, Quanlong Lu, Christine Insinna-Kettenhofen, Kunio Nagashima, Milton A English, Elizabeth M Semler, Jacklyn Mahgerefteh, Artur V Cideciyan, Tiansen Li, Brian P Brooks, Meral Gunay-Aygun, Samuel G Jacobson, Tiziana Cogliati, Christopher J Westlake, Anand Swaroop
Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD). We examined cilia biogenesis and function in cells derived from CEP290-LCA and CEP290-JSRD patients. CEP290 protein was reduced in LCA fibroblasts with no detectable impact on cilia; however, optic cups derived from induced pluripotent stem cells (iPSCs) of CEP290-LCA patients displayed less developed photoreceptor cilia. Lack of CEP290 in JSRD fibroblasts resulted in abnormal cilia and decreased ciliogenesis...
July 11, 2017: Cell Reports
https://www.readbyqxmd.com/read/28700125/optical-assessment-of-mammographic-breast-density-by-a-12-wavelength-versus-a-continuous-spectrum-optical-spectroscopy-device
#20
E Jane Walter, Lothar Lilge
A 12-laser-wavelength, fixed source-detector position, cup-based optical breast spectroscopy (OBS) device was developed for use in large-scale, multi-center trials as a mammographic breast density (MBD) quantification and breast cancer risk pre-screening tool. In this study, the device was evaluated in comparison with a spectrometer-based device used in previous studies. The devices were compared on their ability to predict mammographic percent density (MPD) and to identify women with high MBD from optical spectra...
July 12, 2017: Journal of Biophotonics
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