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https://www.readbyqxmd.com/read/28647622/risk-factors-for-unsuccessful-acetabular-press-fit-fixation-at-primary-total-hip-arthroplasty
#1
Urban Brulc, Vane Antolič, Blaž Mavčič
BACKGROUND: Surgeon at primary total hip arthroplasty sometimes cannot achieve sufficient cementless acetabular press-fit fixation and must resort to other fixation methods. Despite a predominant use of cementless cups, this issue is not fully clarified, therefore we performed a large retrospective study to: 1) identify risk factors related to patient or implant or surgeon for unsuccessful intraoperative press-fit, 2) check for correlation between surgeons' volume of operated cases and the press-fit success rate...
June 21, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28646360/does-the-risk-of-rerevision-vary-between-porous-tantalum-cups-and-other-cementless-designs-after-revision-hip-arthroplasty
#2
Inari Laaksonen, Michelle Lorimer, Kirill Gromov, Ola Rolfson, Keijo T Mäkelä, Stephen E Graves, Henrik Malchau, Maziar Mohaddes
BACKGROUND: Earlier results with porous tantalum acetabular cups in revision THA generally have been favorable. Recently there has been some evidence presented that porous tantalum cups might decrease the risk of rerevision in the setting of revision hip surgery performed owing to prosthetic joint infection (PJI). As the data supporting this assertion come from a study with a limited study population, examining this issue with a large registry approach may be enlightening. QUESTIONS/PURPOSES: By combining results from two large, national registries, we asked: (1) Do porous tantalum cups show improved survival after revision THA compared with other cementless designs? (2) Does the use of porous tantalum cups influence survivorship when rerevision for PJI is the endpoint? METHODS: A total of 2442 first-time THA revisions with porous tantalum cups and 4401 first-time revisions with other uncemented cups were included in this collaborative study between the Australian and Swedish national joint registries...
June 23, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28644941/the-use-of-the-cup-of-diogenes-and-ok-approach-for-carpal-tunnel-surgery
#3
Ahmadreza Afshar
No abstract text is available yet for this article.
July 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28644852/comparisons-of-retinal-vessel-diameter-and-glaucomatous-parameters-between-both-eyes-of-subjects-with-clinically-unilateral-pseudoexfoliation-syndrome
#4
Yasuyuki Takai, Masaki Tanito, Tetsuro Omura, Ryo Kawasaki, Yumiko Kawasaki, Akihiro Ohira
PURPOSE: Pseudoexfoliation syndrome (PEX), the most common identifiable cause of open-angle glaucoma, might affect the retinal hemodynamics. To test this, we compared retinal vessel diameter and glaucoma-related parameters between eyes with pseudoexfoliation material (PE+) and fellow unaffected (PE-) eyes of patients with clinically unilateral PEX. METHODS: The medical records of 30 consecutive Japanese subjects were reviewed retrospectively. The retinal vessel diameters were measured and expressed as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) using standardized software...
2017: PloS One
https://www.readbyqxmd.com/read/28642281/utility-of-genomic-analysis-in-circulating-tumor-dna-from-patients-with-carcinoma-of-unknown-primary
#5
Shumei Kato, Nithya Krishnamurthy, Kimberly C Banks, Pradip De, Kirstin Williams, Casey Williams, Brian Leyland-Jones, Scott M Lippman, Richard B Lanman, Razelle Kurzrock
Carcinoma of unknown primary (CUP) is a rare and difficult-to-treat malignancy, the management of which might be improved by the identification of actionable driver mutations. We interrogated interrogated 54-70 genes in 442 patients with CUP using targeted clinical-grade, next-generation sequencing (NGS) of circulating tumor DNA (ctDNA). Overall, 80% of patients exhibited ctDNA alterations; 66%, ≥ 1 characterized alteration(s) excluding variants of unknown significance. TP53-associated genes were most commonly altered (37...
June 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28641972/equal-primary-fixation-of-resurfacing-stem-but-inferior-cup-fixation%C3%A2-with-anterolateral-vs-posterior-surgical-approach-a-2-year-blinded-randomized-radiostereometric-and-dual-energy-x-ray-absorptiometry-study-of-metal-on-metal-hip-resurfacing-arthroplasty
#6
Mette H Hjorth, Nina D Lorenzen, Kjeld Søballe, Stig S Jakobsen, Maiken Stilling
BACKGROUND: The anterolateral (AntLat) surgical approach may spare the blood supply to the femoral head and improve the accuracy of cup positioning in metal-on-metal hip resurfacing arthroplasty. Thereby, potentially lessen complications such as avascular head necrosis, femoral neck narrowing and fracture, improve implant fixation, and lessen periprosthetic bone mineral density (BMD) loss. METHODS: Between November 2008 and January 2012, a randomized clinical trial was performed at Aarhus University Hospital...
May 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28641967/fluoroscopically-guided-acetabular-component-positioning-does-it-reduce-the-risk-of-malpositioning-in-obese-patients
#7
Raul G Gosthe, Juan C Suarez, Colin A McNamara, Cecilia Calvo, Preetesh D Patel
BACKGROUND: Obesity has been described as an independent risk factor for acetabular component malpositioning. The purpose of this study was to determine if this could be overcome by use of fluoroscopic navigation in total hip arthroplasty (THA). METHODS: The first, postoperative, standing, anteroposterior pelvis radiographs from 1599 consecutive patients who underwent fluoroscopic-guided THAs via anterior approach during a six-year period were obtained. We retrospectively reviewed this prospectively collected data...
May 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28641483/good-performance-of-platinum-based-chemotherapy-for-high-grade-gastroenteropancreatic-and-unknown-primary-neuroendocrine-neoplasms
#8
Giovanni Brandi, Marco Paragona, Davide Campana, Nicole Brighi, Arrigo Bondi, Maria Abbondanza Pantaleo, Jody Corbelli, Maria Aurelia Barbera, Guido Biasco
To evaluate efficacy and safety of platinum and etoposide combination in the treatment of advanced gastroenteropancreatic (GEP) and unknown primary (CUP) neuroendocrine carcinomas (NEC), we analysed the records of 21 consecutive patients treated with this regimen from 1999 to 2012. Objective responses were obtained in 11 patients (52%) and disease stability (DS) in 5 (24%). Median progression-free survival (PFS) was 7 months (95% CI, 5.33-8.66). Median overall survival (OS) was 16 months (95% CI, 14.97-17...
June 22, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28635370/evaluation-of-the-comprehensive-palatability-of-japanese-sake-paired-with-dishes-by-multiple-regression-analysis-based-on-subdomains
#9
Ryo Nakamura, Kumiko Nakano, Hiroyasu Tamura, Masaki Mizunuma, Tohru Fushiki, Dai Hirata
Many factors contribute to palatability. In order to evaluate the palatability of Japanese alcohol sake paired with certain dishes by integrating multiple factors, here we applied an evaluation method previously reported for palatability of cheese by multiple regression analysis based on 3 subdomain factors (rewarding, cultural, and informational). We asked 94 Japanese participants/subjects to evaluate the palatability of sake (1st evaluation/E1 for the first cup, 2nd/E2 and 3rd/E3 for the palatability with aftertaste/afterglow of certain dishes) and to respond to a questionnaire related to 3 subdomains...
June 21, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28633068/multi-electrode-system-for-measurement-of-transmembrane-ion-fluxes-through-living-epithelial-cells
#10
Mirosław Zając, Andrzej Lewenstam, Krzysztof Dolowy
Cystic Fibrosis (CF) is the most common fatal human genetic disease. It is caused by the defect in a single anion channel protein which affects ion and water transport across the epithelial tissue. A flat multi-electrode platform of diameter 12mm, allowing for measurement of four ions: sodium, potassium, hydrogen and chloride by exchangeable/replaceable ion-selective electrodes is described. The measurement is possible owing to the architecture of the platform which accommodates all the electrodes and inlets/outlets...
June 13, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28630848/pseudotumour-complicated-by-implant-loosening-one-year-after-revision-ceramic-on-metal-total-hip-arthroplasty-a-case-report
#11
Devendra Lakhotia, Prashant Kumar
INTRODUCTION: Pseudotumor is not an uncommon complication after total hip arthroplasty (THA). This can occur in relationship to different bearing surfaces of head and liner ranging from soft to hard articulation. There is wide spectrum of presentation from asymptomatic to implant failure. CASE REPORT: We report a case of pseudotumor formation with acetabular cup aseptic loosening after revision ceramic on metal hip arthroplasty. The patient underwent pseudotumor excision and re-revision complex arthroplasty procedure using trabecular metal shell and buttress with ceramic on polyethylene THA...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630821/evaluation-of-practice-trials-to-increase-self-drinking-in-a-child-with-a-feeding-disorder
#12
Kathryn M Peterson, Valerie M Volkert, Suzanne M Milnes
Self-drinking is an important skill for children to acquire as they transition from infancy to early childhood; however, the literature is limited (e.g., Collins, Gast, Wolery, Holcombe, & Leatherby, 1991; Peterson, Volkert, & Zeleny, 2015). We manipulated the consequences associated with self-drinking relative to those associated with being fed along the dimension of response effort. Results demonstrated that self-drinking increased when the child could either choose to self-feed one drink or be fed one drink and 5 practice trials with an empty cup...
June 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/28629944/what-are-the-risk-factors-for-dislocation-in-primary-total-hip-arthroplasty-a-multicenter-case-control-study-of-128-unstable-and-438-stable-hips
#13
M H Fessy, S Putman, A Viste, R Isida, N Ramdane, A Ferreira, A Leglise, B Rubens-Duval, N Bonin, F Bonnomet, A Combes, S Boisgard, D Mainard, S Leclercq, H Migaud
INTRODUCTION: Dislocation after total hip arthroplasty (THA) is a leading reason for surgical revision. The risk factors for dislocation are controversial, particularly those related to the patient and to the surgical procedure itself. The differences in opinion on the impact of these factors stem from the fact they are often evaluated using retrospective studies or in limited patient populations. This led us to carry out a prospective case-control study on a large population to determine: 1) the risk factors for dislocation after THA, 2) the features of these dislocations, and 3) the contribution of patient-related factors and surgery-related factors...
June 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28629942/can-a-target-zone-safer-than-lewinnek-s-safe-zone-be-defined-to-prevent-instability-of-total-hip-arthroplasties-case-control-study-of-56-dislocated-tha-and-93-matched-controls
#14
N Reina, S Putman, R Desmarchelier, E Sari Ali, P Chiron, M Ollivier, J Y Jenny, D Waast, C Mabit, E de Thomasson, C Schwartz, P Oger, L E Gayet, H Migaud, N Ramdane, M H Fessy
BACKGROUND: Various factors contribute to instability of total hip arthroplasty (THA), with implant orientation being a major contributor. We performed a case-control study with computed tomography (CT) data to determine whether 1) orientation contributes to THA instability and 2) a safer target zone for stability than Lewinnek's classic safe zone can be defined. MATERIAL AND METHODS: We included prospectively 363 cases of THA dislocation that occurred during the calendar 2013 year in 24 participating hospitals...
June 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28629518/analysis-of-the-asymmetry-of-activated-epo-receptor-enables-designing-small-molecule-agonists
#15
Frank Guarnieri
Amgen solved the high-resolution cocrystal structure of erythropoietin (EPO) bound to the extracellular part of the receptor (EPOR) in 1998, which reveals that the EPO-EPOR interaction surface is formed by 11 salt bridges, 17 H-bonds, and 2 hydrophobic clusters centered at a pair of crucial phenylalanines (F93). The EPOR has two domains, one that penetrates the membrane and a second extracellular domain that forms one arm of the binding site for the EPO ligand. The complete competent receptor-binding site is a homodimer of EPOR with the two arms forming a funnel-shaped cup where EPO binds...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28629251/neonatal-complications-amoung-596-infants-delivered-by-vacuum-extraction-in-relation-to-characteristics-of-the-extraction
#16
Cecilia Ekéus, Karin Wrangsell, Sandra Penttinen, Katarina Åberg
OBJECTIVE: To investigate the association between complicated vacuum extraction deliveries and neonatal complications. METHODS: Observational study including data on the management of 596 consecutive VE-deliveries at 6 different birth clinics in Sweden in 2013. We used logistic regression to examine the association between a complicated VE and: extracranial bleeding, severe neonatal complication (intracranial hemorrhage and/or asphyxia/low Apgar score and/or convulsions, and/or encephalopathy) and brachial plexus injury...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28626423/ubiquitin-proteasome-collagen-cup-pathway-in-preterm-premature-rupture-of-fetal-membranes
#17
Xinliang Zhao, Xiaoyan Dong, Xiucui Luo, Jing Pan, Weina Ju, Meijiao Zhang, Peirong Wang, Mei Zhong, Yanhong Yu, W Ted Brown, Nanbert Zhong
Spontaneous preterm birth (sPTB) occurs before 37 gestational weeks, with preterm premature rupture of the membranes (PPROM) and spontaneous preterm labor (sPTL) as the predominant adverse outcomes. Previously, we identified altered expression of long non-coding RNAs (lncRNAs) and message RNAs (mRNAs) related to the ubiquitin proteasome system (UPS) in human placentas following pregnancy loss and PTB. We therefore hypothesized that similar mechanisms might underlie PPROM. In the current study, nine pairs of ubiquitin-proteasome-collagen (CUP) pathway-related mRNAs and associated lncRNAs were found to be differentially expressed in PPROM and sPTL...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28625687/can-surgeons-reduce-the-risk-for-dislocation-after-primary-total-hip-arthroplasty-performed-using-the-posterolateral-approach
#18
Kurt G Seagrave, Anders Troelsen, Bjørn G Madsen, Henrik Husted, Thomas Kallemose, Kirill Gromov
BACKGROUND: Hip dislocation is one of the most common postoperative complications after total hip arthroplasty (THA). Potential contributors include patient- and surgical-related factors. We performed a retrospective cohort study to identify risk factors for postoperative dislocation in patients receiving THA via the posterolateral approach. METHODS: We assessed 1326 consecutive primary THAs performed between 2010 and 2015. Patient information was documented, and plain radiographic films were used to evaluate cup positioning, hip offset, and hip length change...
May 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28625014/comparison-in-executive-function-in-chinese-preterm-and-full-term-infants-at-eight-months
#19
Yao Feng, Hong Zhou, Yan Zhang, Anthony Perkins, Yan Wang, Jing Sun
Executive function (EF) is increasingly recognized as being responsible for adverse developmental outcomes in preterm-born infants. Several perinatal factors may lead to poor EF development in infancy, and the deficits in EF can be identified in infants as young as eight months. A prospective cohort study was designed to study the EF in Chinese preterm infants and examine the relationship between EF in preterm infants and maternal factors during perinatal period. A total of 88 preterm infants and 88 full-term infants were followed from birth to eight months (corrected age)...
June 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28624326/randomized-trial-on-illuminated-microcatheter-circumferential-trabeculotomy-versus-conventional-trabeculotomy-in-congenital-glaucoma
#20
Jyoti Shakrawal, Shveta Bali, Talvir Sidhu, Saurabh Verma, Ramanjit Sihota, Tanuj Dada
PURPOSE: To compare one year outcomes of illuminated microcatheter-assisted circumferential trabeculotomy(IMCT) vs conventional partial trabeculotomy(CPT) for Primary Congenital Glaucom (PCG). DESIGN: Randomized clinical trial METHODS: Forty eyes of 31 patients with unilateral or bilateral primary congenital glaucoma aged less than two years were randomized to undergo IMCT (20 eyes) or CPT (20 eyes). Primary outcome measure was IOP reduction. The success criterion was defined as intraocular pressure (IOP) ≤ 12 mm Hg without and with anti-glaucoma medications (absolute success and qualified success respectively)...
June 14, 2017: American Journal of Ophthalmology
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