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https://www.readbyqxmd.com/read/29334416/investigating-causal-associations-between-use-of-nicotine-alcohol-caffeine-and-cannabis-a-two-sample-bidirectional-mendelian-randomization-study
#1
Karin J H Verweij, Jorien L Treur, Jacqueline M Vink
BACKGROUND AND AIMS: Epidemiological studies consistently show co-occurrence of use of different addictive substances. Whether these associations are causal or due to overlapping underlying influences remains an important question in addiction research. Methodological advances have made it possible to use published genetic associations to infer causal relationships between phenotypes. In this exploratory study, we used Mendelian randomization (MR) to examine the causality of well-established associations between nicotine, alcohol, caffeine, and cannabis use...
January 15, 2018: Addiction
https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#2
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29332103/proteomic-effects-of-wet-cupping-al-hijamah
#3
Amer A Almaiman
Wet cupping (Al-hijamah) is a therapeutic technique practiced worldwide as a part of the Unani system of medicine. It involves bloodletting from acupoints on a patient's skin to produce a therapeutic outcome. A thorough review of research articles on wet cupping with relevance to proteomics field that are indexed by Google Scholar, PubMed, and/or Science Direct databases was performed. Eight original research articles were summarized in this paper. Overall, wet cupping did not have a significant effect on C-reactive protein, Hsp-27, sister chromatid exchanges, and cell replication index...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29331442/coffee-consumption-and-risk-of-hypertension-in-the-sun-project
#4
A M Navarro, M A Martinez-Gonzalez, A Gea, R Ramallal, M Ruiz-Canela, E Toledo
BACKGROUND & AIMS: Evidence on coffee consumption and its association with the incidence of hypertension is still inconsistent. The aim of this study was to examine the association of regular or decaffeinated coffee consumption with the risk of developing hypertension in a middle-aged Mediterranean cohort. METHODS: The SUN Project is a prospective open cohort with more than 22,500 Spanish university graduates. For the present study, we analyzed data from 13,374 participants initially free of hypertension (mean follow-up 9...
December 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29331255/an-automated-and-robust-image-processing-algorithm-for-glaucoma-diagnosis-from-fundus-images-using-novel-blood-vessel-tracking-and-bend-point-detection
#5
Soorya M, Ashish Issac, Malay Kishore Dutta
Glaucoma is an ocular disease which can cause irreversible blindness. The disease is currently identified using specialized equipment operated by optometrists manually. The proposed work aims to provide an efficient imaging solution which can help in automating the process of Glaucoma diagnosis using computer vision techniques from digital fundus images. The proposed method segments the optic disc using a geometrical feature based strategic framework which improves the detection accuracy and makes the algorithm invariant to illumination and noise...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29327546/-bone-mineral-density-decreased-is-a-high-risk-factor-for-uncemented-acetabular-cups-migration-in-female-total-hip-arthroplasty-patients
#6
Jia Liu, Jiang Deng, Xiao-Song Han, Lin Xu
OBJECTIVE: To investigate the decrease of bone mineral density in female patients, effects on acetabular displacement. METHODS: From October 2013 to November 2015, a total of 34 patients underwent total hip replacement in the Department of orthopedics, the Third Affiliated Hospital of Zunyi Medical College. The two groups of patients were female and the patients were treated with hip osteoarthritis. Based on the lowest value of preoperative dual energy X-ray bone mineral density (DXA), the patients were divided into normal group and low bone mineral density(-3...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29326501/analysis-of-salivary-iga-amylase-lactoferrin-and-lysozyme-before-and-after-comprehensive-dental-treatment-in-children-a-prospective-study
#7
Akhilesh Sharma, Priya Subramaniam, Shebin Moiden
Objective: This study aimed to evaluate the levels of salivary IgA, amylase, lactoferrin, and lysozyme before and after comprehensive dental treatment in children with early childhood caries. Design: Thirty children aged 36-60 months, with a deft score ≥5, were selected for the study. Before dental treatment, paraffin-stimulated whole saliva was collected in a sterile graduated cup for a period of 5 min. The saliva samples were quantitatively analyzed for levels of IgA, amylase, lactoferrin, and lysozyme using enzyme-linked immunosorbent assay...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326421/vitamin-d3-fortified-milk-did-not-affect-glycemic-control-lipid-profile-and-anthropometric-measures-in-patients-with-type-2-diabetes-a-triple-blind-randomized-clinical-trial
#8
Saedeh Salehi, Fatemeh Sadeghi, Masoumeh Akhlaghi, Mohammad Amin Hanifpour, Mahdi Roshanzamir
BACKGROUND/OBJECTIVES: The effect of vitamin D on glycemic status of diabetes patients is controversial. The objective was to assess the effect of vitamin D3-fortified milk on cardiometabolic markers of patients with type 2 diabetes. SUBJECTS/METHODS: In this randomized triple-blind, placebo-controlled trial, 102 patients (34 males and 68 females) aged 31-74 years with type 2 diabetes were randomized to receive either 250 ml unfortified or 250 ml 1000 IU vitamin D3-fortified milk daily for 9 weeks...
January 11, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29322899/is-the-pelvis-stable-during-supine-total-hip-arthroplasty
#9
S M Shah, W L Walter, J Ngo
Intra- operative changes in pelvic position during total hip arthroplasty (THA) can affect acetabular orientation. We evaluated these changes during supine THA using a proprietary mobile application called PelvicTracker. Twenty- two patients undergoing THA using direct anterior approach were included in the study. In the sagittal plane, the pelvis was extended (anterior tilt) as compared to the start of surgery in 19/ 22 hips at the time of cup implantation (mean extension: 3.1°; range: 1°-6°). In the transverse plane, the pelvis was rolled to the opposite side of surgery in 12 hips (mean roll: 2...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29322072/plan-in-2-d-execute-in-3-d-an-augmented-reality-solution-for-cup-placement-in-total-hip-arthroplasty
#10
Javad Fotouhi, Clayton P Alexander, Mathias Unberath, Giacomo Taylor, Sing Chun Lee, Bernhard Fuerst, Alex Johnson, Greg Osgood, Russell H Taylor, Harpal Khanuja, Mehran Armand, Nassir Navab
Reproducibly achieving proper implant alignment is a critical step in total hip arthroplasty procedures that has been shown to substantially affect patient outcome. In current practice, correct alignment of the acetabular cup is verified in C-arm x-ray images that are acquired in an anterior-posterior (AP) view. Favorable surgical outcome is, therefore, heavily dependent on the surgeon's experience in understanding the 3-D orientation of a hemispheric implant from 2-D AP projection images. This work proposes an easy to use intraoperative component planning system based on two C-arm x-ray images that are combined with 3-D augmented reality (AR) visualization that simplifies impactor and cup placement according to the planning by providing a real-time RGBD data overlay...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29321090/problems-and-resolutions-in-dealing-with-waste-disposable-paper-cups
#11
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2018: Science Progress
https://www.readbyqxmd.com/read/29320923/the-effect-of-seated-pelvic-tilt-on-posterior-edge-loading-in-total-hip-arthroplasty-a-finite-element-investigation
#12
Jim Pierrepont, Long Yang, Jevan Arulampalam, Catherine Stambouzou, Brad Miles, Qing Li
Edge-loading of a ceramic-on-ceramic total hip replacement can lead to reproducible squeaking and revision. A patient's functional acetabular cup orientation, driven by their pelvic tilt, has been shown to be a significant factor in squeaking during hip flexion. The aim of this study was to investigate the effect of seated pelvic tilt on the contact mechanics at the ceramic bearing surface. A finite element model of a ceramic-on-ceramic total hip replacement was created. The cup was orientated at 40° inclination and 15° anteversion relative to the anterior pelvic plane...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29318244/metabolic-fate-of-strawberry-polyphenols-after-chronic-intake-in-healthy-older-adults
#13
Amandeep K Sandhu, Marshall G Miller, Nopporn Thangthaeng, Tammy M Scott, Barbara Shukitt-Hale, Indika Edirisinghe, Britt Burton-Freeman
Strawberries contain a wide array of nutrients and phytochemicals including polyphenols such as anthocyanins, proanthocyanidins and ellagitannins. These polyphenols are absorbed and metabolized to various phenolic metabolites/conjugates in the body, which may play a role in disease risk reduction. In the present study, we investigated the metabolic fate of strawberry polyphenols after chronic (90 days) supplementation of freeze-dried strawberry (24 g d-1, equivalent to 2 cups of fresh strawberries) vs. control powder in 19 healthy older adults...
January 10, 2018: Food & Function
https://www.readbyqxmd.com/read/29317763/a-direct-effect-of-perception-on-action-when-grasping-a-cup
#14
E Rounis, V van Polanen, M Davare
Affordances represent features of an object that trigger specific actions. Here we tested whether the presence and orientation of a handle on a cup could bias grasping movements towards it in conditions where subjects were explicitly told to ignore the handle. We quantified the grip aperture profile of twelve healthy participants instructed to grasp a cup from its body while it either had no handle, a handle pointing towards, or away from the grasping hand (3 'move' conditions, with large grip aperture). To ensure the smaller grip aperture afforded by the handle was implicitly processed, we interspersed trials in which participants had to grasp the cup from its handle or a handle not attached to a cup with a small grip aperture...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315548/treating-liquid-expulsion-in-children-with-feeding-disorders
#15
Rebecca A Shalev, Suzanne M Milnes, Cathleen C Piazza, Jennifer M Kozisek
In the current investigation, we compared and evaluated the effects of two intervention procedures, a modified chin prompt and reclined seating, on the liquid expulsion of 2 children with feeding disorders. For both participants, expulsion decreased to clinically meaningful levels when we added the modified chin prompt or reclined seating to a treatment package consisting of differential reinforcement of acceptance, nonremoval of the cup, and re-presentation. We discuss possible mechanisms underlying the effects of the 2 interventions and areas for future research...
January 8, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29315318/correlative-light-and-immuno-electron-microscopy-of-retinal-tissue-cryostat-sections
#16
Thomas Burgoyne, Amelia Lane, William E Laughlin, Michael E Cheetham, Clare E Futter
Correlative light-electron microscopy (CLEM) is a powerful technique allowing localisation of specific macromolecules within fluorescence microscopy (FM) images to be mapped onto corresponding high-resolution electron microscopy (EM) images. Existing methods are applicable to limited sample types and are technically challenging. Here we describe novel methods to perform CLEM and immuno-electron microscopy (iEM) on cryostat sections utilising the popular FM embedding solution, optimal cutting temperature (OCT) compound...
2018: PloS One
https://www.readbyqxmd.com/read/29313319/early-experience-with-a-tapered-titanium-porous-plasma-sprayed-stem-with-updated-design
#17
Antonio G Manocchio, Keith R Berend, Michael J Morris, Joanne B Adams, Adolph V Lombardi
INTRODUCTION: The Taperloc® Complete femoral stem (Zimmer Biomet, Warsaw, Indiana) builds on the widespread clinical success of the original Taperloc design used since 1982. Enhancements to the Complete design include a lowered caput-collum-diaphyseal (CCD) angle from 138° to 133° for improved offset, optimized neck taper with polished neck flats to increase range of motion, reduced distal geometry to improve proximal canal fill, and gradual off-loading that is the goal of tapered geometry...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29312852/acetabular-cup-version-modelling-and-its-clinical-applying-on-plain-radiograms
#18
Anton Denisov, Stanislav Bilyk, Anton Kovalenko
AIM: To measure the sensitivity and specificity of the cup version assessment by using only anteroposterior hip and pelvis views, evaluate the incidence of inadequate cup version in patients with repeated dislocations after total hip arthroplasty (THA). METHODS: Radiographic retrospective analysis of 2 groups of patients, with follow up of 6-60 mo, after undergoing primary THA. First group of 32 patients (20 female, 12 male) with unilateral THA (32 hips) required early revision arthroplasty for reasons of dislocation...
December 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29312846/role-of-fast-setting-cements-in-arthroplasty-a-comparative-analysis-of-characteristics
#19
Neil Ayron Caraan, Reinhard Windhager, Jason Webb, Nadine Zentgraf, Klaus-Dieter Kuehn
AIM: To evaluate the behaviour of two fast-setting polymethylmethacrylate (PMMA) cements CMW® 2G and Palacos® fast R + G, as reference: Standard-setting Palacos® R + G. METHODS: The fast-setting cements CMW® 2G and Palacos® fast R + G were studied, using standard-setting high viscosity Palacos® R + G as a reference. Eleven units (of two batch numbers) of each cement were tested. All cements were mixed as specified by the manufacturer and analysed on the following parameters: Handling properties (mixing, waiting, working and hardening phase) according to Kuehn, Mechanical properties according to ISO 5833 and DIN 53435, Fatigue strength according to ISO 16402, Benzoyl Peroxide (BPO) - Content by titration, powder/liquid-ratio by weighing, antibiotic elution profile by High Performance Liquid Chromatography...
December 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29310048/alcohol-operant-self-administration-investigating-how-alcohol-seeking-behaviors-predict-drinking-in-mice-using-two-operant-approaches
#20
Mariah B Blegen, Daniel da Silva E Silva, Roland Bock, Nadege Morisot, Dorit Ron, Veronica A Alvarez
Alcohol operant self-administration paradigms are critical tools for studying the neural circuits implicated in both alcohol-seeking and consummatory behaviors and for understanding the neural basis underlying alcohol-use disorders. In this study, we investigate the predictive value of two operant models of oral alcohol self-administration in mice, one in which alcohol is delivered into a cup following nose-poke responses with no accurate measurement of consumed alcohol solution, and another paradigm that provides access to alcohol via a sipper tube following lever presses and where lick rate and consumed alcohol volume can be measured...
August 19, 2017: Alcohol
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