keyword
MENU ▼
Read by QxMD icon Read
search

Urgent start

keyword
https://www.readbyqxmd.com/read/28736391/-i-wanted-to-safeguard-the-baby-a-qualitative-study-to-understand-the-experiences-of-option-b-for-pregnant-women-and-the-potential-implications-for-test-and-treat-in-four-sub-saharan-african-settings
#1
Estelle McLean, Jenny Renju, Joyce Wamoyi, Dominic Bukenya, William Ddaaki, Kathryn Church, Basia Zaba, Alison Wringe
OBJECTIVE: To explore what influences on engagement with Option B+ in four sub-Saharan African settings. METHODS: In-depth interviews were conducted in 2015, with 22 HIV-positive women who had been pregnant since Option B+ was available, and 15 healthcare workers (HCWs) involved in HIV service delivery. Participants were purposely selected from four health and demographic surveillance sites in Malawi, Tanzania and Uganda. A thematic content analysis was conducted to investigate what influenced engagement with Option B+...
July 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28736131/variation-in-organization-of-transient-ischemic-attack-care-in-the-netherlands-a-nationwide-survey-study
#2
Fenna Floortje Muller, Frank de Beer, Marieke Christine Visser
BACKGROUND: Previous research has shown the importance of urgent initiation of antiplatelet therapy after transient ischemic attack (TIA) to reduce the risk of stroke. Many hospitals in the Netherlands have therefore implemented rapid pathways for assessment of patients with TIA. Dutch stroke guidelines lack clear directives for organization of TIA assessment and thus allow for variation. The aim of this study was to investigate variation in organization of TIA assessment in Dutch hospitals...
July 20, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28724489/population-genetic-structure-of-the-cayo-santiago-colony-of-rhesus-macaques-macaca-mulatta
#3
Sreetharan Kanthaswamy, Robert F Oldt, Jillian Ng, Angelina V Ruiz-Lambides, Elizabeth Maldonado, Melween I Martínez, Carlos A Sariol
The rhesus macaque population at Cayo Santiago increases annually and is in urgent need of control. In-depth assessments of the colony's population genetic and pedigree structures provide a starting point for improving the colony's long-term management program. We evaluated the degree of genetic variation and coefficients of inbreeding and kinship of the Cayo Santiago colony by using pedigree and short tandem repeat (STR) data from 4738 rhesus macaques, which represent 7 extant social groups and a group of migrant males...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28723464/how-to-use-antimicrobial-prophylaxis-in-urological-procedures
#4
Tommaso Cai, Gernot Bonkat, Zafer Tandogdu, Riccardo Bartoletti, Florian M E Wagenlehner, Magnus Grabe, Truls E Bjerklund Johansen
A revision of clinical practice in terms of antimicrobial prophylaxis is urgently needed starting from: (1) obtaining information about local pathogen profiles and antimicrobial resistance, (2) evaluating all patient-related risk factors for the development of infectious complications, (3) and prescribing antimicrobials according to the principles of the European Association of Urology guidelines.
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28707895/a-lightweight-and-ultrastrong-polymer-foam-with-unusually-superior-flame-retardancy
#5
Linli Xu, Linhong Xiao, Pan Jia, Karel Goossens, Peng Liu, Hui Li, Chungui Cheng, Yong Huang, Christopher Bielawski, Jianxin Geng
High-performance flame-retardant materials are urgently needed to address outstanding issues that pertain to safety. Traditional flame retardants are toxic to the environment and/or lack the physical properties required for use in many contemporary applications. Here, we show that isocyanate-based polyimide (PI) foams, a flammable material, can exhibit unusually superior flame retardancy as well as other excellent properties, such as being light weight and displaying high mechanical strength, by incorporating red phosphorus (RP)-hybridized graphene...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28702359/cerebral-toxoplasmosis-requiring-urgent-brain-biopsy
#6
Moamen Al Zoubi, Beenish Zulfiqar, Mandavi Kulkarni
A 39-yerar-old man was admitted to our hospital with behavioral disturbances and generalized headaches. He was diagnosed with CNS toxoplasmosis after performing a brain biopsy. He found to be HIV positive with a CD4 of 14/uL He was started on ant toxoplasmosis along with antiretroviral therapy. He presented 6 weeks after discharge with worsening headache thought to be related to relapse of toxoplasmosis. However, he found to have severe anemia related to CMV-induced gastrointestinal bleeding. He was started on anti-cytomegalovirus drugs and has finally achieved significant improvement...
2017: IDCases
https://www.readbyqxmd.com/read/28700715/the-pharmacological-and-non-pharmacological-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-systematic-review-with-network-meta-analyses-of-randomised-trials
#7
Ferrán Catalá-López, Brian Hutton, Amparo Núñez-Beltrán, Matthew J Page, Manuel Ridao, Diego Macías Saint-Gerons, Miguel A Catalá, Rafael Tabarés-Seisdedos, David Moher
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed psychiatric disorders in childhood. A wide variety of treatments have been used for the management of ADHD. We aimed to compare the efficacy and safety of pharmacological, psychological and complementary and alternative medicine interventions for the treatment of ADHD in children and adolescents. METHODS AND FINDINGS: We performed a systematic review with network meta-analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28698495/discovery-of-dna-topoisomerase-i-inhibitors-with-low-cytotoxicity-based-on-virtual-screening-from-natural-products
#8
Lan-Ting Xin, Lu Liu, Chang-Lun Shao, Ri-Lei Yu, Fang-Ling Chen, Shi-Jun Yue, Mei Wang, Zhong-Long Guo, Ya-Chu Fan, Hua-Shi Guan, Chang-Yun Wang
Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe toxic effects. Therefore, it is urgent to find and develop novel low toxic Topo I inhibitors. In recent years, during our ongoing research on natural antitumor products, a collection of low cytotoxic or non-cytotoxic compounds with various structures were identified from marine invertebrates, plants, and their symbiotic microorganisms...
July 9, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28681444/a-call-to-incorporate-systems-theory-and-human-factors-into-the-existing-investigation-of-harm-in-clinical-research-involving-healthcare-products
#9
Bernard Bégaud, Esther Daemen, Ioannis Dokas, Brian Edwards, Jonathan M Fishbein, Howard E Greenberg, Alan Hochberg, Hervé Le Louet, Jytte Lyngvig, Nataliya Mogles, Kathryn Owen, Christine Prendergast, Martin Rejzek, Sofia Trantza, David Webb, Matthew Whalen, Simon Whiteley
This is a joint statement from individual pharmacology and pharmaceutical professionals acting in their own capacity including members of the Alliance for Clinical Research Excellence and Safety (ACRES) and the International Society of Pharmacovigilance (ISoP). By building on the extensive pharmacological and regulatory investigations that already take place, we are calling for a fuller and more robust systems-based approach to the independent investigation of clinical research when serious incidents of harm occur, starting with first-in-human clinical trials...
July 6, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28666561/emergency-magnetic-resonance-imaging-3-tiered-prioritization
#10
Juan E Small, Stacey Sullivan-Richard, Lisa A Kingsley Rocker, Jacob J Kim, Jennifer C Broder
BACKGROUND/PURPOSE: Traditional methods for prioritization are limited and insufficient for today's magnetic resonance imaging (MRI) demands. In particular, the discrepancy in urgency of the heterogeneous emergency department (ED) patient population necessitates risk stratification to meet different degrees of urgency. The purpose of this study is to more effectively prioritize the MRI imaging needs of ED patients commensurate with the severity of their presenting illness. METHODS: A 3-level tiered classification system (tier 1: critical, tier 2: emergent, and tier 3: urgent) of ED patients with unambiguous hierarchically defined numerical classifications was implemented to replace a traditional method of MRI orders...
May 17, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28660852/population-genetic-structure-of-the-cayo-santiago-colony-of-rhesus-macaques-macaca-mulatta
#11
Sreetharan Kanthaswamy, Robert F Oldt, Jillian Ng, Angelina V Ruiz-Lambides, Elizabeth Maldonado, Melween I Martínez, Carlos A Sariol
The rhesus macaque population at Cayo Santiago increases annually and is in urgent need of control. In-depth assessmentsof the colony's population genetic and pedigree structures provide a starting point for improving the colony's long-termmanagement program. We evaluated the degree of genetic variation and coefficients of inbreeding and kinship of the CayoSantiago colony by using pedigree and short tandem repeat (STR) data from 4738 rhesus macaques, which represent 7 extantsocial groups and a group of migrant males...
June 28, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28656588/allergic-contact-dermatitis-caused-by-meth-acrylates-in-long-lasting-nail-polish%C3%A2-%C3%A2-are-we-facing-a-new-epidemic-in-the-beauty-industry
#12
Maria-Elena Gatica-Ortega, Maria-Antonia Pastor-Nieto, Pedro Mercader-García, Juan-Francisco Silvestre-Salvador
BACKGROUND: Allergic contact dermatitis (ACD) caused by (meth)acrylates has been described both in occupational and in non-occupational settings. OBJECTIVES: To evaluate the clinical patterns, the most frequent allergens and the prognosis in patients sensitized to (meth)acrylates in long-lasting nail polish. METHODS: The files of patients with ACD caused by (meth)acrylates in long-lasting nail polish diagnosed between January 2013 and June 2016 in four dermatology departments in Spain were reviewed...
June 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28651870/advanced-nutrient-removal-from-surface-water-by-a-consortium-of-attached-microalgae-and-bacteria-a-review
#13
REVIEW
Junzhuo Liu, Yonghong Wu, Chenxi Wu, Koenraad Muylaert, Wim Vyverman, Han-Qing Yu, Raúl Muñoz, Bruce Rittmann
Innovative and cost-effective technologies for advanced nutrient removal from surface water are urgently needed for improving water quality. Conventional biotechnologies, such as ecological floating beds, or constructed wetlands, are not effective in removing nutrients present at low-concentration. However, microalgae-bacteria consortium is promising for advanced nutrient removal from wastewater. Suspended algal-bacterial systems can easily wash out unless the hydraulic retention time is long, attached microalgae-bacteria consortium is more realistic...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28646406/podocytes-and-the-quest-for-precision-medicines-for-kidney-diseases
#14
REVIEW
Peter Mundel
In this review, I describe a 30-year journey in the quest for precision medicines for patients with kidney diseases. In 1987, when I started my reseach career, most scientists studying glomerular disease biology were focused on mesangial cells. The crucial role of the podocyte in many kidney diseases characterized by proteinuria, including focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy, had not yet been recognized. We were not aware of genetic causes or drivers of kidney diseases nor of molecular markers and cell culture systems for mechanistic studies of podocyte biology...
June 23, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28633650/effects-of-tolvaptan-in-patients-with-acute-heart-failure-a-systematic-review-and-meta-analysis
#15
Chunbin Wang, Bo Xiong, Lin Cai
BACKGROUND: Acute heart failure, which requires urgent evaluation and treatment, is a leading cause for admission to the emergency department. The aim of this meta-analysis was to evaluate the effects of tolvaptan on acute heart failure and compare them with the effects of conventional therapy or placebo. METHODS: The electronic databases PubMed, EMBASE, and the Cochrane Controlled Trial registry were searched from their starting dates to October 24, 2016. Two authors independently read the trials and extracted related information from the included studies...
June 20, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28630250/amplification-of-mglu5-endocannabinoid-signaling-rescues-behavioral-and-synaptic-deficits-in-a-mouse-model-of-adolescent-and-adult-dietary-polyunsaturated-fatty-acids-imbalance
#16
Antonia Manduca, Anissa Bara, Thomas Larrieu, Olivier Lassalle, Corinne Joffre, Sophie Layé, Olivier J Manzoni
Energy-dense, yet nutritionally-poor food is a high-risk factor for mental health disorders. This is of particular concern during adolescence, a period often associated with increased consumption of low nutritional content food and higher prevalence of mental health disorders. Indeed, there is an urgent need to understand the mechanisms linking unhealthy diet and mental disorders. Deficiency in n-3 polyunsaturated fatty acid (PUFAs) is a hallmark of poor nutrition and mood disorders. Here, we developed a mouse model of n-3 PUFAs deficiency lasting from adolescence into adulthood...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28630035/the-effects-of-preoperative-volume-replacement-in-diabetic-patients-undergoing-coronary-artery-bypass-grafting-surgery-protocol-for-a-randomized-controlled-trial-verdict-trial
#17
Madeleine Clout, Tracy Harris, Chris Rogers, Lucy Culliford, Jodi Taylor, Gianni Angelini, Pradeep Narayan, Barnaby Reeves, James Hillier, Kate Ashton, Kunal Sarkar, Raimondo Ascione
BACKGROUND: Diabetes mellitus is a major risk factor for prolonged hospital stays, renal failure, and mortality in patients having coronary artery bypass grafting (CABG). Complications pose a serious threat to patients and prolong intensive care and hospital stays. Low glomerular filtration rate (GFR) due to existing renal impairment or volume depletion may exacerbate acute renal impairment/failure in these patients. Preoperative volume replacement therapy (VRT) is reported to increase the GFR and we hypothesize that VRT will reduce renal impairment and related complications in diabetic patients...
June 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28629226/no-significant-impact-of-foxf1-sirna-treatment-in-acute-and-chronic-ccl4-liver-injury
#18
Kerstin Abshagen, Tobias Rotberg, Berit Genz, Brigitte Vollmar
Chronic liver injury of any etiology is the main trigger of fibrogenic responses and thought to be mediated by hepatic stellate cells. Herein, activating transcription factors like forkhead box f1 are described to stimulate pro-fibrogenic genes in hepatic stellate cells. By using a liver-specific siRNA delivery system (DBTC), we evaluated whether forkhead box f1 siRNA treatment exhibit beneficial effects in murine models of acute and chronic CCl4-induced liver injury. Systemic administration of DBTC-forkhead box f1 siRNA in mice was only sufficient to silence forkhead box f1 in acute CCl4 model, but was not able to attenuate liver injury as measured by liver enzymes and necrotic liver cell area...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28617487/organ-on-a-chip-devices-advance-to-market
#19
Boyang Zhang, Milica Radisic
To curb the high cost of drug development, there is an urgent need to develop more predictive tissue models using human cells to determine drug efficacy and safety in advance of clinical testing. Recent insights gained through fundamental biological studies have validated the importance of dynamic cell environments and cellular communication to the expression of high fidelity organ function. Building on this knowledge, emerging organ-on-a-chip technology is poised to fill the gaps in drug screening by offering predictive human tissue models with methods of sophisticated tissue assembly...
June 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28611977/clinicopathology-of-early-gastric-carcinoma-an-update-for-pathologists-and-gastroenterologists
#20
REVIEW
Qin Huang, Xiaoping Zou
BACKGROUND: The WHO defines early gastric carcinoma (EGC) as invasive carcinoma up to the submucosal layer, regardless of nodal metastasis. The recent study results indicate that EGC varies in location, histology, nodal metastasis, and prognosis. SUMMARY: The heterogeneity in EGC may be related to various types of epithelial stem cells. The most important stem cells include Lgr5(+) cells at the base of a gastric unit in the antrum-pylorus-cardia, Mist1(+) cells at the isthmus/Troy(+) cells at the base in the corpus-fundus, and Sox2(+) cells at the base in almost all regions...
March 2017: Gastrointestinal Tumors
keyword
keyword
12673
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"