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Steven Habbous, Eric McArthur, Stephanie N Dixon, Susan McKenzie, Carlos Garcia-Ochoa, Ngan N Lam, Krista L Lentine, Christine Dipchand, Kenneth Litchfield, Mehmet A Begen, Sisira Sarma, Amit X Garg
BACKGROUND: Preemptive kidney transplants result in better outcomes and patient experiences than transplantation after dialysis onset. It is unknown how often a person initiates maintenance dialysis prior to living kidney donor transplantation when their donor candidate evaluation is well underway. METHODS: Using healthcare databases, we retrospectively studied 478 living donor kidney transplants from 2004-2014 across 5 transplant centres in Ontario, Canada where the recipients were not receiving dialysis when their donor's evaluation was well underway...
March 10, 2018: Transplantation
Martin Everett, Nicolas Sprynski, Alicia Coelho, Jérôme Castandet, Maëlle Bayet, Juliette Bougnon, Clarisse Lozano, David T Davies, Simon Leiris, Magdalena Zalacain, Ian Morrissey, Sophie Magnet, Kirsty Holden, Peter Warn, Filomena De Luca, Jean-Denis Docquier, Marc Lemonnier
Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are increasingly prevalent and have become a major worldwide threat to human health. Carbapenem resistance is driven primarily by the acquisition of β-lactamase enzymes which are able to degrade carbapenem antibiotics (hence termed carbapenemases) and can result in high levels of resistance and treatment failure. Clinically relevant carbapenemases include both serine-β-lactamases (SBLs, e.g. KPC-2 and OXA-48) and metallo-β-lactamases (MBLs), such as NDM-1...
March 12, 2018: Antimicrobial Agents and Chemotherapy
Mehdi Ben Khelil, Majed Kamel, Sana Lahmar, Ali Mrabet, Nabiha Borsali Falfoul, Moncef Hamdoun
OBJECTIVE: Assess Death Certificates accuracy (DCs) issued by a teaching emergency department in Tunis. METHODS: It is a descriptive study. We included all death certificates issued in the Emergency Department of a teaching Hospital in Tunis over 17 months period (October 2013 - March 2014). Twenty-one errors have been predefined and classified as "Editing errors" or "Medical analysis error" then as major or minor errors. RESULTS: 757 certificates were studied; all DCs had at least three errors with an average number of errors of 6...
June 2017: La Tunisie Médicale
Masato Habuka, Yoko Wada, Yoichi Kurosawa, Suguru Yamamoto, Yusuke Tani, Riuko Ohashi, Yoichi Ajioka, Masaaki Nakano, Ichiei Narita
BACKGROUND: Visceral disseminated varicella zoster viral (VZV) infection is a rare but severe complication with a high mortality rate in immunosuppressed individuals, and an increased susceptibility to VZV has been reported in kidney transplant recipients who are treated with mycophenolate mofetil (MMF). In Japan, MMF is currently approved for patients with lupus nephritis (LN) and data to indicate its optimal dosage are still insufficient. CASE PRESENTATION: A 46-year-old Japanese woman with rheumatoid arthritis was diagnosed as having systemic lupus erythematosus (SLE) and LN class III (A/C)...
March 5, 2018: BMC Research Notes
Perko Vukotic, Nevenka Antovic, Andrija Djurovic, Ranko Zekic, Nikola Svrkota, Tomislav Andjelic, Ranko Svrkota, Radivoje Mrdak, Natasa Bjelica, Tamara Djurovic, Aleksandar Dlabac, Marija Bogicevic
The first nationwide indoor radon survey in Montenegro started in 2002 and year-long radon measurements with CR-39 track-etch detectors, within the national grid of 5 km × 5 km and local grids in urban areas of 0.5 km × 0.5 km, were performed in homes in half of the country's territory. The survey continued in 2014 and measurements in the rest of the country were completed at the end of 2015. The 953 valid results, obtained in the national radon survey, give an average radon activity concentration in Montenegrin homes of 110 Bq/m3 ...
February 28, 2018: Journal of Environmental Radioactivity
Alicja Baranowska, Paweł Baranowski, Tadeusz Płusa
Infection of the surgical operation site is found in approximately 3% of patients and 20% of patients undergoing urgent surgery. The occurrence of this type of complications is affected both by coexisting diseases and the presence of infection in the environment in which the patient is staying. It should also be taken into account that the bacteria found in the implanted material and surrounding tissues have the ability to adhere to the implant, creating a biofilm structure there. The presented patient is an illustration of such a problem, because after L5 laminectomy and extensive L2-L3 and L3-L4 one-sided fenestration and L2-L3-L4-L5 facetectomy, interbody bone arthrodesis and transpedicular stabilization, he reported for fever and pain in right lumbar area...
February 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Jens Christian König, Andrea Titieni, Martin Konrad
Hereditary cystic kidney diseases comprise a complex group of genetic disorders representing one of the most common causes of end-stage renal failure in childhood. The main representatives are autosomal recessive polycystic kidney disease, nephronophthisis, Bardet-Biedl syndrome, and hepatocyte nuclear factor-1beta nephropathy. Within the last years, genetic efforts have brought tremendous progress for the molecular understanding of hereditary cystic kidney diseases identifying more than 70 genes. Yet, genetic heterogeneity, phenotypic variability, a lack of reliable genotype-phenotype correlations and the absence of disease-specific biomarkers remain major challenges for physicians treating children with cystic kidney diseases...
2018: Frontiers in Pediatrics
Junru Chen, Haoran Zhang, Guangxi Sun, Xingming Zhang, Jinge Zhao, Jiandong Liu, Pengfei Shen, Ming Shi, Hao Zeng
OBJECTIVE: The aim of the study was to systematically review the relevant studies to evaluate the prognosis of primary and progressive muscle-invasive bladder cancer (MIBC) after radical cystectomy (RC) and provide a clue for the timing of RC in patients with progressive MIBC early at the time of high-risk non-muscle-invasive bladder cancer (NMIBC). MATERIAL AND METHODS: PubMed, MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched for eligible studies...
February 26, 2018: International Journal of Surgery
Cassandra K Kisby, Michael R Polin, Anthony G Visco, Nazema Y Siddiqui
OBJECTIVE: The aim of the study was to compare unplanned postoperative encounters in women discharged same day versus later after robotic-assisted sacrocolpopexy (RA-SCP). METHODS: This is a retrospective cohort study of women who underwent RA-SCP at a tertiary care center January 2013 to September 2015. Women were divided into 2 cohorts based on their day of discharge: (1) same day or (2) postoperative day 1 (POD ≥ 1) or later. Our primary outcome was unplanned provider visits (clinic, urgent care, emergency department, or hospital readmission) during the 6 weeks after surgery...
February 27, 2018: Female Pelvic Medicine & Reconstructive Surgery
Martina Penazzato, Linda Lewis, Melynda Watkins, Vineet Prabhu, Fernando Pascual, Martin Auton, Wesley Kreft, Sébastien Morin, Marissa Vicari, Janice Lee, David Jamieson, George K Siberry
INTRODUCTION: Despite the coordinated efforts by several stakeholders to speed up access to HIV treatment for children, development of optimal paediatric formulations still lags 8 to 10 years behind that of adults, due mainly to lack of market incentives and technical complexities in manufacturing. The small and fragmented paediatric market also hinders launch and uptake of new formulations. Moreover, the problems affecting HIV similarly affect other disease areas where development and introduction of optimal paediatric formulations is even slower...
February 2018: Journal of the International AIDS Society
Maisnam Manorama, Sunkam NarayanaIyengar Ramanujam
Puntius shalynius is a highly endemic freshwater minor carp that is economically important and is threatened because of its ornamental value. The present investigation evaluated this barb gonadal maturation, based on morphology and spawning of this species in the Umiam river, Meghalaya, India. The population of this indigenous fish has declined due to its fragmented distribution and exploitation as an ornamental fish. The reproductive cycle of P. shalynius was studied for the first time. A total of 609 fish samples were randomly collected from the river for a period of two years during January 2010 and December 2011...
March 2017: Revista de Biología Tropical
Benjamin Pedrazzini, Dela Golshayan, Daniel Teta
Renal transplantation is the first-line therapy for eligible patients with end-stage kidney disease. However, approximately 20 % of cadaveric graft recipients need to start dialysis at 5 years. The transition period between transplantation and dialysis is at high risk of complications, but data exploring this issue are scarce. In this retrospective study from dialysis centres of the Canton de Vaud, we analysed the clinical data and management of these patients at the beginning of dialysis after graft loss, and up to one year after dialysis start...
February 21, 2018: Revue Médicale Suisse
Azar Tahghighi, Safoura Karimi, Arezoo Rafie Parhizgar, Sedigheh Zakeri
Objectives: Due to the rapid increased drug resistance to Plasmodium parasites, an urgent need to achieve new antiplasmodial drugs is felt. Therefore, in this study, the new synthetic phenanthroline derivatives were synthesized with antiplasmodial activity. Materials and Methods: A series of 1,10-phenanthroline derivatives containing amino-alcohol and amino-ether substituents were synthesized via facile procedures, starting with 5,6-epoxy-1,10-phenanthroline. Their antiplasmodial activity was then evaluated using Peter's 4-day suppressive test against Plasmodium berghei-infected mice (ANKA strain)...
February 2018: Iranian Journal of Basic Medical Sciences
Shankar Kumar, Simon de Lusignan, Andrew McGovern, Ana Correa, Mariya Hriskova, Piers Gatenby, Simon Jones, David Goldsmith, A John Camm
OBJECTIVE: To assess the association between anticoagulation, ischaemic stroke, gastrointestinal and cerebral haemorrhage, and all cause mortality in older people with atrial fibrillation and chronic kidney disease. DESIGN: Propensity matched, population based, retrospective cohort analysis from January 2006 through December 2016. SETTING: The Royal College of General Practitioners Research and Surveillance Centre database population of almost 2...
February 14, 2018: BMJ: British Medical Journal
Paolo Borro, Silvana G Dellepiane, Rinaldo Pellicano, Laura Gemme, Sharmila Fagoonee, Gianni Testino
OBJECTIVE: The need for a staging of hepatic fibrosis has become particularly urgent in the last few years in order to start new therapeutic treatments. The objective of this study is to identify ultrasound descriptors and achieve a staging of hepatic fibrosis with non-invasive, rapid and inexpensive methods, both as an alternative and a support to the ultrasound elastography examination. MATERIALS AND METHODS: This study evaluated 196 patients under treatment at the Alcohological Regional Center...
February 13, 2018: Panminerva Medica
Veerendra Koppolu, T Shantha Raju
Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika causes mildly symptomatic infections fever, headache, rash, arthralgia, and conjunctivitis, the recent outbreak associated ZIKV to serious neurological complications such as microcephaly, Guillain-Barré syndrome, and eye infections...
February 13, 2018: Journal of Neurovirology
Aleix Elizalde-Torrent, Fernando Val, Ingrid Cardoso C Azevedo, Wuelton M Monteiro, Luiz C L Ferreira, Carmen Fernández-Becerra, Hernando A Del Portillo, Marcus V G Lacerda
BACKGROUND: Splenomegaly is one of the most common features of malaria. However, spontaneous splenic rupture, although unusual, represents a severe complication often leading to death. It is mostly seen in acute infection and primary attack, and it is most commonly associated with Plasmodium vivax. Here, a case of spontaneous splenic rupture diagnosed with a portable ultrasound apparatus shortly after starting treatment and with recurrent parasitaemia after splenectomy, is reported. CASE DESCRIPTION: In November 2015, a 45-year-old Brazilian man presented to the hospital in Manaus with fever, headache and myalgia...
February 13, 2018: Malaria Journal
Brendan Maughan-Brown, Philip Smith, Caroline Kuo, Abigail Harrison, Mark N Lurie, Linda-Gail Bekker, Omar Galárraga
Interventions to improve antiretroviral therapy (ART) access are urgently needed to maximize the multiple benefits from ART. This pilot study examined the effect of a conditional economic incentive on linkage to care and uptake of treatment following ART referral by a mobile health clinic. Between April 2015 and May 2016, 86 individuals (≥18 years old) referred for ART in a resource-limited setting were randomized (1:1) to a control group or to an incentive: R300 cash (∼$23, or 3.5 days minimum wage in the domestic worker sector), conditional upon starting ART within 3 months...
February 2018: AIDS Patient Care and STDs
Masami Kashimura, Toshiaki Nomura, Akiko Ishiwata, Shin Kitamura
As the number of people with dementia in Japan continues to rise, family caregivers are experiencing an increasing care burden. Previous research has shown that this care burden can affect family caregivers' physical and mental health. Therefore, providing support for caregivers of family members with dementia has become an urgent issue in the country. The purpose of this study was to investigate the feasibility of applying STrAtegies for RelaTives (START), a psychosocial intervention programme developed in the UK to improve caregivers' moods and quality of life, to Japanese family caregivers...
February 11, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Prasad Thota, Anusha Thota, Bikash Medhi, Shabir Sidhu, Pramod Kumar, V Kalai Selvan, Gyanendra Nath Singh
Background: The National Coordination Centre-Pharmacovigilance Programme of India (NCC-PvPI), Indian Pharmacopoeia Commission works under the aegis of Ministry of Health and Family Welfare, Government of India. It promotes patient safety in India and also supports postmarketing surveillance programs. Currently, almost hundred thousand case reports are submitted to NCC-PvPI each year through its 250 ADR Monitoring Centers (AMCs) located across India, and India is the one of the top ten contributor countries under WHO-Uppsala Monitoring Centre since 2012 and start issuing drug safety alerts from March 2016...
January 2018: Perspectives in Clinical Research
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