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https://www.readbyqxmd.com/read/27910820/4d-bioprinting-the-next-generation-technology-for-biofabrication-enabled-by-stimuli-responsive-materials
#1
Yi-Chen Li, Yu Shrike Zhang, Ali Akpek, Su Ryon Shin, Ali Khademhosseini
Four-dimensional (4D) bioprinting, encompassing a wide range of disciplines including bioengineering, materials science, chemistry, and computer sciences, is emerging as the next-generation biofabrication technology. By utilizing stimuli-responsive materials and advanced three-dimensional (3D) bioprinting strategies, 4D bioprinting aims to create dynamic 3D patterned biological structures that can transform their shapes or behavior under various stimuli. In this review, we highlight the potential use of various stimuli-responsive materials for 4D printing and their extension into biofabrication...
December 2, 2016: Biofabrication
https://www.readbyqxmd.com/read/27908164/comparison-of-low-contrast-detectability-between-two-ct-reconstruction-algorithms-using-voxel-based-3d-printed-textured-phantoms
#2
Justin Solomon, Alexandre Ba, François Bochud, Ehsan Samei
PURPOSE: To use novel voxel-based 3D printed textured phantoms in order to compare low-contrast detectability between two reconstruction algorithms, FBP (filtered-backprojection) and SAFIRE (sinogram affirmed iterative reconstruction) and determine what impact background texture (i.e., anatomical noise) has on estimating the dose reduction potential of SAFIRE. METHODS: Liver volumes were segmented from 23 abdominal CT cases. The volumes were characterized in terms of texture features from gray-level co-occurrence and run-length matrices...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27907008/an-assemblable-multi-angle-fluorescence-and-ellipsometric-microscope
#3
Victoria Nguyen, John Rizzo, Babak Sanii
We introduce a multi-functional microscope for research laboratories that have significant cost and space limitations. The microscope pivots around the sample, operating in upright, inverted, side-on and oblique geometries. At these geometries it is able to perform bright-field, fluorescence and qualitative ellipsometric imaging. It is the first single instrument in the literature to be able to perform all of these functionalities. The system can be assembled by two undergraduate students from a provided manual in less than a day, from off-the-shelf and 3D printed components, which together cost approximately $16k at 2016 market prices...
2016: PloS One
https://www.readbyqxmd.com/read/27906687/economic-3d-printing-approach-for-transplantation-of-human-stem-cell-derived-%C3%AE-like-cells
#4
Jiwon Song, Jeffrey R Millman
Transplantation of human pluripotent stem cells (hPSC) differentiated into insulin-producing β cells is a regenerative medicine approach being investigated for diabetes cell replacement therapy. This report presents a multifaceted transplantation strategy that combines differentiation into stem cell-derived β (SC-β) cells with 3D printing. By modulating the parameters of a low-cost 3D printer, we created a macroporous device composed of polylactic acid (PLA) that houses SC-β cell clusters within a degradable fibrin gel...
December 1, 2016: Biofabrication
https://www.readbyqxmd.com/read/27906156/biomimetic-sniffing-improves-the-detection-performance-of-a-3d-printed-nose-of-a-dog-and-a-commercial-trace-vapor-detector
#5
Matthew E Staymates, William A MacCrehan, Jessica L Staymates, Roderick R Kunz, Thomas Mendum, Ta-Hsuan Ong, Geoffrey Geurtsen, Greg J Gillen, Brent A Craven
Unlike current chemical trace detection technology, dogs actively sniff to acquire an odor sample. Flow visualization experiments with an anatomically-similar 3D printed dog's nose revealed the external aerodynamics during canine sniffing, where ventral-laterally expired air jets entrain odorant-laden air toward the nose, thereby extending the "aerodynamic reach" for inspiration of otherwise inaccessible odors. Chemical sampling and detection experiments quantified two modes of operation with the artificial nose-active sniffing and continuous inspiration-and demonstrated an increase in odorant detection by a factor of up to 18 for active sniffing...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904481/3d-printed-nerve-guidance-channels-computer-aided-control-of-geometry-physical-cues-biological-supplements-and-gradients
#6
Blake N Johnson, Xiaofeng Jia
No abstract text is available yet for this article.
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27903193/three-dimensional-assessment-of-the-effects-of-high-density-embolization-material-on-the-absorbed-dose-in-the-target-for-gamma-knife-radiosurgery-of-arteriovenous-malformations
#7
Yoichi Watanabe, Divyajot Sandhu, Leighton Warmington, Sean Moen, Ramachandra Tummala
OBJECTIVE Arteriovenous malformation (AVM) is an intracranial vascular disorder. Gamma Knife radiosurgery (GKRS) is used in conjunction with intraarterial embolization to eradicate the nidus of AVMs. Clinical results indicate that patients with prior embolization tend to gain less benefit from GKRS. The authors hypothesized that this was partly caused by dosimetric deficiency. The actual dose delivered to the target may be smaller than the intended dose because of increased photon attenuation by high-density embolic materials...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27898010/applications-of-alginate-based-bioinks-in-3d-bioprinting
#8
REVIEW
Eneko Axpe, Michelle L Oyen
Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill the considerable requirements for suitable bioink formulation, a critical component of efficient 3D bioprinting. Alginate, a naturally occurring polysaccharide, is clearly the most commonly employed material in current bioinks. Here, we discuss the benefits and disadvantages of the use of alginate in 3D bioprinting by summarizing the most recent studies that used alginate for printing vascular tissue, bone and cartilage...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27897397/development-and-validation-of-a-septoplasty-training-model-using-3-dimensional-printing-technology
#9
Mahmoud A AlReefi, Lily H P Nguyen, Luc G Mongeau, Bassam Ul Haq, Siddharth Boyanapalli, Nauman Hafeez, Francois Cegarra-Escolano, Marc A Tewfik
BACKGROUND: Providing alternative training modalities may improve trainees' ability to perform septoplasty. Three-dimensional printing has been shown to be a powerful tool in surgical training. The objectives of this study were to explain the development of our 3-dimensional (3D) printed septoplasty training model, to assess its face and content validity, and to present evidence supporting its ability to distinguish between levels of surgical proficiency. METHODS: Imaging data of a patient with a nasal septal deviation was selected for printing...
November 29, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27897197/on-site-rapid-diagnosis-of-intracranial-hematoma-using-portable-multi-slice-microwave-imaging-system
#10
Ahmed Toaha Mobashsher, A M Abbosh
Rapid, on-the-spot diagnostic and monitoring systems are vital for the survival of patients with intracranial hematoma, as their conditions drastically deteriorate with time. To address the limited accessibility, high costs and static structure of currently used MRI and CT scanners, a portable non-invasive multi-slice microwave imaging system is presented for accurate 3D localization of hematoma inside human head. This diagnostic system provides fast data acquisition and imaging compared to the existing systems by means of a compact array of low-profile, unidirectional antennas with wideband operation...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895985/multi-channel-multi-distance-broadband-near-infrared-spectroscopy-system-to-measure-the-spatial-response-of-cellular-oxygen-metabolism-and-tissue-oxygenation
#11
Phong Phan, David Highton, Jonathan Lai, Martin Smith, Clare Elwell, Ilias Tachtsidis
We present a multi-channel, multi-distance broadband near-infrared spectroscopy (NIRS) system with the capability of measuring changes in haemoglobin concentrations (Δ[HbO2], Δ[HHb]), oxidation state of cytochrome-c-oxidase (Δ[oxCCO]) and tissue oxygen saturation (TOI) in the adult human brain. The main components of the instrument are two customized spectrographs and two light sources. Each spectrograph is lens-based to improve light throughput, has a grating enhanced to optimise reflection in the near-infrared (NIR) spectral region and uses a front illuminated cooled CCD camera (-70° C) with a square chip dimension of 12...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27892655/3d-printed-polycaprolactone-carbon-nanotube-composite-scaffolds-for-cardiac-tissue-engineering
#12
Chee Meng Benjamin Ho, Abhinay Mishra, Pearlyn Teo Pei Lin, Sum Huan Ng, Wai Yee Yeong, Young-Jin Kim, Yong-Jin Yoon
Fabrication of tissue engineering scaffolds with the use of novel 3D printing has gained lot of attention, however systematic investigation of biomaterials for 3D printing have not been widely explored. In this report, well-defined structures of polycaprolactone (PCL) and PCL- carbon nanotube (PCL-CNT) composite scaffolds have been designed and fabricated using a 3D printer. Conditions for 3D printing has been optimized while the effects of varying CNT percentages with PCL matrix on the thermal, mechanical and biological properties of the printed scaffolds are studied...
November 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27892493/autologous-temporomandibular-joint-reconstruction-independent-of-exogenous-additives-a-proof-of-concept-study-for-guided-self-generation
#13
Jiao Wei, Tanja Herrler, Dong Han, Kai Liu, Rulin Huang, Markus Guba, Chuanchang Dai, Qingfeng Li
Joint defects are complex and difficult to reconstruct. By exploiting the body's own regenerative capacity, we aimed to individually generate anatomically precise neo-tissue constructs for autologous joint reconstruction without using any exogenous additives. In a goat model, CT scans of the mandibular condyle including articular surface and a large portion of the ascending ramus were processed using computer-aided design and manufacturing. A corresponding hydroxylapatite negative mold was printed in 3D and temporarily embedded into the transition zone of costal periosteum and perichondrium...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27889111/minimally-invasive-fixation-in-tibial-plateau-fractures-using-an-pre-operative-and-intra-operative-real-size-3d-printing
#14
Silvio Giannetti, Nicola Bizzotto, Andrea Stancati, Attilio Santucci
The purpose of our study was to compare the outcome after minimally invasive reconstruction and internal fixation with and without the use of pre- and intra-operative real size 3D printing for patients with displaced tibial plateau fractures (TPFs). We prospectively followed up 40 consecutive adult patients with closed TPF who underwent surgical treatment of reconstruction of the tibial plateau with the use of minimally invasive fixation. Sixteen patients (group 1) were operated using a pre-operative and intra-operative real size 3D-model, while 24 patients (group 2) were operated without 3D-model printing, but using only pre-operative and intra-operative 3D Tc-scan images...
November 18, 2016: Injury
https://www.readbyqxmd.com/read/27888725/functional-response-of-osteoblasts-in-functionally-gradient-titanium-alloy-mesh-arrays-processed-by-3d-additive-manufacturing
#15
K C Nune, A Kumar, R D K Misra, S J Li, Y L Hao, R Yang
We elucidate here the osteoblasts functions and cellular activity in 3D printed interconnected porous architecture of functionally gradient Ti-6Al-4V alloy mesh structures in terms of cell proliferation and growth, distribution of cell nuclei, synthesis of proteins (actin, vinculin, and fibronectin), and calcium deposition. Cell culture studies with pre-osteoblasts indicated that the interconnected porous architecture of functionally gradient mesh arrays was conducive to osteoblast functions. However, there were statistically significant differences in the cellular response depending on the pore size in the functionally gradient structure...
November 18, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27887969/flexible-head-casts-for-high-spatial-precision-meg
#16
Sofie S Meyer, James Bonaiuto, Mark Lim, Holly Rossiter, Sheena Waters, David Bradbury, Sven Bestmann, Matthew Brookes, Martina F Callaghan, Nikolaus Weiskopf, Gareth R Barnes
BACKGROUND: In combination with magnetoencephalographic (MEG) data, accurate knowledge of the brain's structure and location provide a principled way of reconstructing neural activity with high temporal resolution. However, measuring the brain's location is compromised by head movement during scanning, and by fiducial-based co-registration with magnetic resonance imaging (MRI) data. The uncertainty from these two factors introduces errors into the forward model and limit the spatial resolution of the data...
November 22, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27886664/degradation-behaviors-of-geometric-cues-and-mechanical-properties-in-a-3d-scaffold-for-tendon-repair
#17
Yang Wu, Yoke San Wong, Jerry Ying Hsi Fuh
A three-dimensional (3D) scaffold fabricated via electrohydrodynamic jet printing (E-jetting) and thermally uniaxial stretching, has been developed for tendon tissue regeneration in our previous study. In this study, more in-depth biological test showed that the aligned cell morphology guided by the anisotropic geometries of the 3D tendon scaffolds, leading to up-regulated tendious gene expression including collagen type I, decorin, tenascin-C and biglycan, as compared to the electrospun scaffolds. Given the importance of geometric cues to the biological function of the scaffolds, the degradation behaviors of the 3D scaffolds were investigated...
November 25, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27886051/a-laminar-flow-based-microfluidic-tesla-pump-via-lithography-enabled-3d-printing
#18
Mohammed-Baker Habhab, Tania Ismail, Joe Fujiou Lo
Tesla turbine and its applications in power generation and fluid flow were demonstrated by Nicholas Tesla in 1913. However, its real-world implementations were limited by the difficulty to maintain laminar flow between rotor disks, transient efficiencies during rotor acceleration, and the lack of other applications that fully utilize the continuous flow outputs. All of the aforementioned limits of Tesla turbines can be addressed by scaling to the microfluidic flow regime. Demonstrated here is a microscale Tesla pump designed and fabricated using a Digital Light Processing (DLP) based 3D printer with 43 µm lateral and 30 µm thickness resolutions...
November 23, 2016: Sensors
https://www.readbyqxmd.com/read/27884347/fabrication-of-three-dimensional-scan-to-print-ear-model-for-microtia-reconstruction
#19
Byoungjun Jeon, Chiwon Lee, Myungjoon Kim, Tae Hyun Choi, Sungwan Kim, Sukwha Kim
BACKGROUND: Microtia is a congenital deformity of the external ear that occurs in 1 of every 5000 births. Microtia reconstruction using traditional two-dimensional templates does not provide highly detailed ear shapes. Here, we describe the feasibility of using a three-dimensional (3D) ear model as a reference. MATERIALS AND METHODS: Seven children aged from 11 to 16 (6 grade III and 1 grade II microtia) were recruited from Seoul National University Children's Hospital, Korea...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27883051/lipid-coated-microbubbles-and-low-intensity-pulsed-ultrasound-enhance-chondrogenesis-of-human-mesenchymal-stem-cells-in-3d-printed-scaffolds
#20
Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar
Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone...
November 24, 2016: Scientific Reports
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