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https://www.readbyqxmd.com/read/28812982/quantitative-criteria-to-benchmark-new-and-existing-bio-inks-for-cell-compatibility
#1
Karen Dubbin, Anthony Tabet, Sarah Heilshorn
Recent advancements in 3D bioprinting have led to the fabrication of more complex, more precise, and larger printed tissue constructs. As the field continues to advance, it is critical to develop quantitative benchmarks to compare different bio-inks for key cell-biomaterial interactions, including (1) cell sedimentation within the ink cartridge, (2) cell viability during extrusion, and (3) cell viability after ink curing. Here we develop three simple protocols for quantitative analysis of bio-ink performance...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28812141/next-generation-of-ventricular-catheters-for-hydrocephalus-based-on-parametric-designs
#2
M Galarza, A Giménez, J M Amigó, M Schuhmann, R Gazzeri, U Thomale, J P McAllister
BACKGROUND: The flow pattern of the cerebrospinal fluid is probably the most important factor related to obstruction of ventricular catheters during the normal treatment of hydrocephalus. To better comprehend the flow pattern, we have carried out a parametric study via numerical models of ventricular catheters. In previous studies, the flow was studied under steady and, recently, in pulsatile boundary conditions by means of computational fluid dynamics (CFD) in three-dimensional catheter models...
August 15, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28811751/bioactive-potential-of-3d-printed-oleo-gum-resin-disks-b-papyrifera-c-myrrha-and-s-benzoin-loading-nanooxides-tio2-p25-cu2o-and-moo3
#3
Diogo José Horst, Sergio Mazurek Tebcherani, Evaldo Toniolo Kubaski, Rogério de Almeida Vieira
This experimental study investigates the bioactive potential of filaments produced via hot melt extrusion (HME) and intended for fused deposition modeling (FDM) 3D printing purposes. The oleo-gum-resins from benzoin, myrrha, and olibanum in pure state and also charged with 10% of metal oxide nanoparticles, TiO2, P25, Cu2O, and MoO3, were characterized by ultraviolet-visible (UV-Vis) and Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray microanalysis (EDXMA), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC)...
2017: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/28809488/text-displaying-colorimetric-paper-based-analytical-device
#4
Kentaro Yamada, Koji Suzuki, Daniel Citterio
This paper describes a paper-based analytical device allowing the direct semiquantitative interpretation of the result of a chemical assay in the form of "text". The combined use of a classical colorimetric indicator system and an additional inert colorant enables a versatile text-displaying detection mechanism on a paper device. For proof-of-concept, urinary protein has been selected as a model analytical target. The whole text-displaying paper device has been developed based on printing techniques including wax printing, inkjet printing, and 3D printing...
August 15, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28808803/a-prototype-educational-model-for-hepatobiliary-interventions-unveiling-the-role-of-graphic-designers-in-medical-3d-printing
#5
Ramin Javan, Merissa N Zeman
In the context of medical three-dimensional (3D) printing, in addition to 3D reconstruction from cross-sectional imaging, graphic design plays a role in developing and/or enhancing 3D-printed models. A custom prototype modular 3D model of the liver was graphically designed depicting segmental anatomy of the parenchyma containing color-coded hepatic vasculature and biliary tree. Subsequently, 3D printing was performed using transparent resin for the surface of the liver and polyamide material to develop hollow internal structures that allow for passage of catheters and wires...
August 14, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28808235/direct-ink-write-diw-3d-printed-cellulose-nanocrystal-aerogel-structures
#6
Vincent Chi-Fung Li, Conner K Dunn, Zhe Zhang, Yulin Deng, H Jerry Qi
Pure cellulose nanocrystal (CNC) aerogels with controlled 3D structures and inner pore architecture are printed using the direct ink write (DIW) technique. While traditional cellulosic aerogel processing approaches lack the ability to easily fabricate complete aerogel structures, DIW 3D printing followed by freeze drying can overcome this shortcoming and can produce CNC aerogels with minimal structural shrinkage or damage. The resultant products have great potential in applications such as tissue scaffold templates, drug delivery, packaging, etc...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807205/facilitating-surgeon-understanding-of-complex-anatomy-using-a-three-dimensional-printed-model
#7
Barrett P Cromeens, William C Ray, Brad Hoehne, Fikir Abayneh, Brent Adler, Gail E Besner
BACKGROUND: 3-dimensional prints (3DP) anecdotally facilitate surgeon understanding of anatomy and decision-making. However, the actual benefit to surgeons or patients has not been quantified. This study investigates how surgeon understanding of complex anatomy is altered by a 3DP compared to computed tomography (CT) scan or CT + digital reconstruction (CT + DR). MATERIALS AND METHODS: Key anatomic features were segmented from a CT-abdomen/pelvis of pygopagus twins to build a DR and printed in color on a 3D printer...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28806052/one-step-nanoscale-electrohydrodynamic-inkjet-three-dimensional-printing-technique-with-spontaneous-joule-heating
#8
Bin Zhang, Baekhoon Seong, Jaehyun Lee, VuDat Nguyen, DaeHyun Cho, Doyoung Byun
A one-step nanoscale electrohydrodynamic (EHD) inkjet three-dimensional (3D)-printing technique that is based on the drop-on-demand (DOD) operation for which an additional post-sintering process is not required is proposed. Both the numerical simulation and the experimental observations proved that nanoscale Joule heating occurs at the interface between the charged silver nanoparticles (Ag-NPs) because of the high electrical contact resistance during the printing process; this is the reason why an additional post-sintering process is not required...
August 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28805010/characterization-of-hydrogels-made-of-a-novel-spider-silk-protein-emasp1s-and-evaluation-for-3d-printing
#9
Christopher Thamm, Elise DeSimone, Thomas Scheibel
Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into scaffolds. Further, blending with a recombinantly produced MaSp2 derivative eADF4(C16) alters the mechanical properties of the resulting hydrogels. Different spider silk hydrogels also show a distinct recovery after a high shear stress deformation, exhibiting the tunability of their features for selected applications...
August 14, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28804996/in-vitro-evaluation-of-3d-bioprinted-tri-polymer-network-scaffolds-for-bone-tissue-regeneration
#10
Stephanie T Bendtsen, Mei Wei
In vitro evaluations provide vital information on the ability of tissue engineered scaffolds to support cell life and promote natural physiological behaviors in culture. Such assessments are necessary to conduct before implementation of the scaffolds for tissue healing in vivo. The scaffold extracellular matrix must provide the biochemical and mechanical cues necessary to promote cellular attachment, migration and proliferation before differentiation and new tissue deposition can occur. In this study, an in vitro evaluation was conducted to assess the ability of scaffolds 3D printed with a previously developed alginate-polyvinyl alcohol-hydroxyapatite formulation to promote proliferation of encapsulated MC3T3 cells...
August 14, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28801685/investigation-on-ti6al4v-v-cr-fe-ss316-multi-layers-metallic-structure-fabricated-by-laser-3d-printing
#11
Wei Li, Frank Liou, Joseph Newkirk, Karen M Brown Taminger, William J Seufzer
Joining titanium alloy and stainless steel is becoming an urgent need since their outstanding mechanical properties can be utilized integratedly. However, direct fusion joining of Ti6Al4V to SS316 can cause brittle Ti-Fe intermetallics which compromise join bonds' mechanical properties. In this research, Laser 3D Printing was applied to explore a new Ti6Al4V to SS316 multi-metallic structure. A novel filler transition route was introduced (Ti6Al4V → V → Cr → Fe → SS316) to avoid the Ti-Fe intermetallics...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800768/3d-printing-assisted-preoperative-plan-of-pedicle-screw-placement-for-middle-upper-thoracic-trauma-a-cohort-study
#12
Wei Xu, Xuming Zhang, Tie Ke, Hongru Cai, Xiang Gao
BACKGROUND: This study aimed to evaluate the application of 3D printing in assisting preoperative plan of pedicle screw placement for treating middle-upper thoracic trauma. METHODS: A preoperative plan was implemented in seven patients suffering from middle-upper thoracic (T3-T7) trauma between March 2013 and February 2016. In the 3D printing models, entry points of 56 pedicle screws (Magerl method) and 4 important parameters of the pedicle screws were measured, including optimal diameter (ϕ, mm), length (L, mm), inclined angle (α), head-tilting angle (+β), and tail-tilting angle (-β)...
August 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28800287/measuring-and-establishing-the-accuracy-and-reproducibility-of-3d-printed-medical-models
#13
Elizabeth George, Peter Liacouras, Frank J Rybicki, Dimitrios Mitsouras
Despite the rapid growth of three-dimensional (3D) printing applications in medicine, the accuracy and reproducibility of 3D printed medical models have not been thoroughly investigated. Although current technologies enable 3D models to be created with accuracy within the limits of clinical imaging spatial resolutions, this is not always achieved in practice. Inaccuracies are due to errors that occur during the imaging, segmentation, postprocessing, and 3D printing steps. Radiologists' understanding of the factors that influence 3D printed model accuracy and the metrics used to measure this accuracy is key in directing appropriate practices and establishing reference standards and validation procedures...
August 11, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28798855/printed-microfluidic-filter-for-heparinized-blood
#14
Stanley E R Bilatto, Nouran Y Adly, Daniel S Correa, Bernhard Wolfrum, Andreas Offenhäusser, Alexey Yakushenko
A simple lab-on-a-chip method for blood plasma separation was developed by combining stereolithographic 3D printing with inkjet printing, creating a completely sealed microfluidic device. In some approaches, one dilutes the blood sample before separation, reducing the concentration of a target analyte and increasing a contamination risk. In this work, a single drop (8 μl) of heparinized whole blood could be efficiently filtered using a capillary effect without any external driving forces and without dilution...
May 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28798843/an-easily-fabricated-three-dimensional-threaded-lemniscate-shaped-micromixer-for-a-wide-range-of-flow-rates
#15
Mehdi Rafeie, Marcel Welleweerd, Amin Hassanzadeh-Barforoushi, Mohsen Asadnia, Wouter Olthuis, Majid Ebrahimi Warkiani
Mixing fluid samples or reactants is a paramount function in the fields of micro total analysis system (μTAS) and microchemical processing. However, rapid and efficient fluid mixing is difficult to achieve inside microchannels because of the difficulty of diffusive mass transfer in the laminar regime of the typical microfluidic flows. It has been well recorded that the mixing efficiency can be boosted by migrating from two-dimensional (2D) to three-dimensional (3D) geometries. Although several 3D chaotic mixers have been designed, most of them offer a high mixing efficiency only in a very limited range of Reynolds numbers (Re)...
January 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28797120/medication-eluting-devices-for-the-field-of-obgyn-medobgyn-3d-printed-biodegradable-hormone-eluting-constructs-a-proof-of-concept-study
#16
Karthik Tappa, Udayabhanu Jammalamadaka, David H Ballard, Todd Bruno, Marissa R Israel, Harika Vemula, J Mark Meacham, David K Mills, Pamela K Woodard, Jeffery A Weisman
3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using polycaprolactone (PCL) biodegradable polymer laden with estrogen or progesterone and were subjected to hormone-release profile studies using ELISA kits. Material thermal properties were tested using thermogravimetric analysis and differential scanning calorimetry...
2017: PloS One
https://www.readbyqxmd.com/read/28797089/therapeutic-response-assessment-using-3d-ultrasound-for-hepatic-metastasis-from-colorectal-cancer-application-of-a-personalized-3d-printed-tumor-model-using-ct-images
#17
Ye Ra Choi, Jung Hoon Kim, Sang Joon Park, Bo Yun Hur, Joon Koo Han
BACKGROUND & AIMS: To evaluate accuracy and reliability of three-dimensional ultrasound (3D US) for response evaluation of hepatic metastasis from colorectal cancer (CRC) using a personalized 3D-printed tumor model. METHODS: Twenty patients with liver metastasis from CRC who underwent baseline and after chemotherapy CT, were retrospectively included. Personalized 3D-printed tumor models using CT were fabricated. Two radiologists measured volume of each 3D printing model using 3D US...
2017: PloS One
https://www.readbyqxmd.com/read/28797066/computationally-designed-lattices-with-tuned-properties-for-tissue-engineering-using-3d-printing
#18
Paul F Egan, Veronica C Gonella, Max Engensperger, Stephen J Ferguson, Kristina Shea
Tissue scaffolds provide structural support while facilitating tissue growth, but are challenging to design due to diverse property trade-offs. Here, a computational approach was developed for modeling scaffolds with lattice structures of eight different topologies and assessing properties relevant to bone tissue engineering applications. Evaluated properties include porosity, pore size, surface-volume ratio, elastic modulus, shear modulus, and permeability. Lattice topologies were generated by patterning beam-based unit cells, with design parameters for beam diameter and unit cell length...
2017: PloS One
https://www.readbyqxmd.com/read/28796185/performance-of-electropun-polyacrylonitrile-nanofibrous-phases-shown-for-the-separation-of-water-soluble-food-dyes-via-utlc-vis-esi-ms
#19
Pimolpun Niamlang, Pitt Supaphol, Gertrud E Morlock
Research in the miniaturization of planar chromatography led to various approaches in manufacturing ultrathin-layer chromatography (UTLC) layers of reduced thickness (<50 µm) along with smaller instrumentation, as targeted in Office Chromatography. This novel concept merges 3D print & media technologies with miniaturized planar chromatography to realize an all-in-one instrument, in which all steps of UTLC are automated and integrated in the same tiny device. In this context, the development of electrospun polyacrylonitrile (PAN) nanofiber phases was investigated as well as its performance...
August 10, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28796182/fabrication-and-characterization-of-3d-printed-highly-porous-3d-lifepo%C3%A2-electrodes-by-low-temperature-direct-writing-process
#20
Changyong Liu, Xingxing Cheng, Bohan Li, Zhangwei Chen, Shengli Mi, Changshi Lao
LiFePO₄ (LFP) is a promising cathode material for lithium-ion batteries. In this study, low temperature direct writing (LTDW)-based 3D printing was used to fabricate three-dimensional (3D) LFP electrodes for the first time. LFP inks were deposited into a low temperature chamber and solidified to maintain the shape and mechanical integrity of the printed features. The printed LFP electrodes were then freeze-dried to remove the solvents so that highly-porous architectures in the electrodes were obtained. LFP inks capable of freezing at low temperature was developed by adding 1,4 dioxane as a freezing agent...
August 10, 2017: Materials
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