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https://www.readbyqxmd.com/read/28743121/a-severe-case-of-hemoglobin-h-disease-due-to-compound-heterozygosity-for-deletion-of-the-major-%C3%AE-globin-regulatory-element-mcs-r2-and-%C3%AE-0-thalassemia
#1
Lv-Yin Huang, Jin-Mei Yan, Jian-Ying Zhou, Jian Li, Xing-Mei Xie, Dong-Zhi Li
No abstract text is available yet for this article.
July 26, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28743078/metabolite-identification-of-azd8055-in-sprague-dawley-rats-after-a-single-oral-administration-using-ultra-performance-liquid-chromatography-and-mass-spectrometry
#2
Md Mamunur Rashid, Hyun-A Oh, Hyunbeom Lee, Byung Hwa Jung
AZD8055 is an ATP-competitive specific dual mTOR inhibitor and exhibited potent antitumor activity on several types of solid tumors. However, the metabolism of AZD8055 in the body still remains unknown. In this study, metabolite identification of AZD8055 was performed using ultra high-performance liquid chromatography-ion trap mass spectrometry (UHPLC-IT-MS) through both in vitro and in vivo approaches using rat liver microsomes (RLMs) and rat plasma, urine and feces, respectively. A total of eight putative metabolites (five phase I and three phase II) were identified, and a tentative metabolic pathway was suggested for the first time...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28743077/characterization-and-quantitative-analysis-of-phenolic-derivatives-in-longxuetongluo-capsule-by-hplc-dad-it-tof-ms
#3
Jing Sun, Yuelin Song, Hui Sun, Wenjing Liu, Yunfeng Zhang, Jiao Zheng, Qian Zhang, Yunfang Zhao, Wei Xiao, Pengfei Tu, Jun Li
Longxuetongluo Capsule (LTC), which is derived from the total phenolic extract of Chinese dragon's blood, has been proved to be safe as well as effective towards ischemic stroke. However, the effective material basis remains unclear. The present study thereby focused on the clarification of the qualitative and quantitative properties for the phenolic derivatives in LTC. Regarding homolog-focused chemical profiling, the mass fragmentation patterns of the primary subtypes of phenolic compounds such as homoisoflavanones, flavanes, chalcones, and flavonoid oligomers were summarized by assaying authentic references with hybrid ion trap time-of-flight mass spectrometry, and the chemical structures of 124 phenolic compounds, in total, were unambiguously or tentatively annotated in LTC by matching the accurate mass spectral profiles with the proposed mass cracking rules and those reference substances...
July 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28743073/in-situ-biodegradation-potential-of-1-2-dca-and-vc-at-sites-with-different-hydrogeological-settings
#4
R C M Nobre, M M M Nobre, T M P Campos, D Ogles
This paper investigates the feasibility of applying in-situ Bioremediation (ISB) to three sites contaminated with vinyl chloride and/or chlorinated alkanes such as 1,2-DCA and 1,1,2-TCA, presenting distinct hydrogeological settings and history of contaminant loading. Biotransformation of these compounds is well established in laboratory studies and pure cultures. Due to confidential aspects, however, few field data are available to support real case studies to the predictability of their fate and lifetime in soil and groundwater...
July 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28743039/exogenous-application-of-poly-%C3%AE-glutamic-acid-enhances-stress-defense-in-brassica-napus-l-seedlings-by-inducing-cross-talks-between-ca-2-h2o2-brassinolide-and-jasmonic-acid-in-leaves
#5
Zongqi Xu, Peng Lei, Xiao Pang, Huashan Li, Xiaohai Feng, Hong Xu
Poly-γ-glutamic acid (γ-PGA) is a microbe-secreted isopeptide shown to promote growth and enhance crop stress tolerance. However, its downstream signaling pathways are unknown. Here, we studied γ-PGA-induced tolerance to salt and cold stresses. Pretreatment with γ-PGA contributed to enhance stress tolerance of canola seedlings by promoting proline accumulation and total antioxidant capacity (T-AOC) improvement. Further, Ca(2+), H2O2, brassinolide, and jasmonic acid were found to be involved in the γ-PGA-induced process...
July 17, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28742986/adsorption-of-mesitylene-via-mesoporous-adsorbents
#6
Kai Chun Nien, Feng Tang Chang, Moo Been Chang
Mesitylene (or 1,3,5-trimethylbenzene) is a volatile organic compound emitted from various industrial processes, e.g., spray coating. Its emissions have become a critical issue because mesitylene is toxic and cannot be removed using traditional adsorbents, e.g., zeolite (H-ZSM-5; the diameter of mesitylene molecules is greater than the pore size of H-ZSM-5). Hence, an adsorbent with a large pore size, MCM-41, is used in this study to investigate its adsorption capacity for mesitylene and is compared with that of H-ZSM-5...
July 25, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28742931/dynamics-of-lipids-and-metabolites-during-the-cell-cycle-of-chlamydomonas-reinhardtii
#7
Jessica Jüppner, Umarah Mubeen, Andrea Leisse, Camila Caldana, Henrike Brust, Martin Steup, Marion Herrmann, Dirk Steinhauser, Patrick Giavalisco
Metabolites and lipids are the final products of enzymatic processes, distinguishing the different cellular functions and activities of single cells or whole tissues. Understanding these cellular functions within a well-established model system, requires a systemic collection of molecular and physiological information. In the current report, the green algae Chlamydomonas reinhardtii was selected to establish a comprehensive workflow for the detailed multi-omics analysis of a synchronously growing cell culture system...
July 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28742929/a-structurally-characterized-cu-iii-complex-supported-by-a-bis-anilido-ligand-and-its-oxidative-catalytic-activity
#8
Fabrice Thomas, Amelie Kochem, Jennifer K Molloy, Gisèle Gellon, Nicolas Leconte, Christian Philouze, Olivier Jarjayes, Florian Berthiol
Three copper(II) complexes of the (R,R)-N,N'-Bis(3,5-di-tert-butyl-2-aminobenzylidene)-1,2-diaminocyclohexane, namely [Cu(NL)], [Cu(NLH)]+ and [Cu(NLH2)]2+, were prepared and structurally characterized. In [Cu(NLH2)]2+ the copper ion lies in an octahedral geometry with the aniline groups coordinated in equatorial positions. In [Cu(NL)] the anilines are deprotonated (anilido moieties) and coordinated to an almost square metal ion. Complex [Cu(NL)] displays two oxidation waves at E1/2ox,1 = -0.14 V and E1/2ox,2 = 0...
July 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28742863/antibacterial-activity-of-tannins-isolated-from-sapium-baccatum-extract-and-use-for-control-of-tomato-bacterial-wilt
#9
Thuy Thu Vu, Hun Kim, Vu Khac Tran, Hoang Dinh Vu, Tien Xuan Hoang, Jae Woo Han, Yong Ho Choi, Kyoung Soo Jang, Gyung Ja Choi, Jin-Cheol Kim
In the search for new antibacterial agents from natural sources, we revealed that a crude methanol extract of Sapium baccatum was highly active against Ralstonia solanacearum, a causal agent of a serious disease called bacterial wilt of tomato. The bioassay-guided fractionation of this extract resulted in the isolation of seven known active compounds, including gallic acid, methyl gallate, corilagin, tercatain, chebulagic acid, chebulinic acid, and quercetin 3-O-α-L-arabinopyranoside. Their chemical structures were determined by electrospray ionization mass spectrometry and nuclear magnetic resonance spectroscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28742852/in-vitro-and-in-vivo-anti-inflammatory-active-copper-ii-lawsone-complexes
#10
Ján Vančo, Zdeněk Trávníček, Jan Hošek, Pavel Suchý
We report in vitro and in vivo anti-inflammatory activities of a series of copper(II)-lawsone complexes of the general composition [Cu(Law)2(LN)x(H2O)(2-x)]·yH2O; where HLaw = 2-hydroxy-1,4-naphthoquinone, x = 1 when LN = pyridine (1) and 2-aminopyridine (3) and x = 2 when LN = imidazole (2), 3-aminopyridine (4), 4-aminopyridine (5), 3-hydroxypyridine (6), and 3,5-dimethylpyrazole (7). The compounds were thoroughly characterized by physical techniques, including single crystal X-ray analysis of complex 2. Some of the complexes showed the ability to suppress significantly the activation of nuclear factor κB (NF-κB) both by lipopolysaccharide (LPS) and TNF-alpha (complexes 3-7 at 100 nM level) in the similar manner as the reference drug prednisone (at 1 μM level)...
2017: PloS One
https://www.readbyqxmd.com/read/28742842/new-hydrazonoindolin-2-ones-synthesis-exploration-of-the-possible-anti-proliferative-mechanism-of-action-and-encapsulation-into-plga-microspheres
#11
Mohamed I Attia, Wagdy M Eldehna, Samar A Afifi, Adam B Keeton, Gary A Piazza, Hatem A Abdel-Aziz
The synthesis and molecular characterization of new isatin-based hydrazonoindolin-2-ones 4a-o and 7a-e are reported. The in vitro anti-proliferative potential of the synthesized compounds 4a-o and 7a-e was examined against HT-29 (colon), ZR-75 (breast) and A549 (lung) human cancer cell lines. Compounds 7b, 7d and 7e were the most active congeners against the tested human cancer cell lines with average IC50 values of 4.77, 3.39 and 2.37 μM, respectively, as compared with the reference isatin-based drug, sunitinib, which exhibited an average IC50 value of 8...
2017: PloS One
https://www.readbyqxmd.com/read/28742687/the-allosteric-hemoglobin-effector-itpp-inhibits-metastatic-colon-cancer-in-mice
#12
Perparim Limani, Michael Linecker, Marcel A Schneider, Philipp Kron, Christoph Tschuor, Ekaterina Kachaylo, Udo Ungethuem, Claude Nicolau, Jean-Marie Lehn, Rolf Graf, Bostjan Humar, Pierre-Alain Clavien
OBJECTIVE: To test the effects of enhanced intracellular oxygen contents on the metastatic potential of colon cancer. BACKGROUND: Colorectal cancer is the commonest gastrointestinal carcinoma. Distant metastases occur in half of patients and are responsible for most cancer-related deaths. Tumor hypoxia is central to the pathogenesis of metastases. Myo-Inositoltrispyrophosphate (ITPP), a nontoxic, antihypoxic compound, has recently shown significant benefits in experimental cancer, particularly when combined with standard chemotherapy...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742635/long-exercise-test-in-the-interattack-period-of-periodic-paralysis-a-useful-and-sensitive-diagnostic-tool
#13
Jiaoting Jin, Fangfang Hu, Min Li, Suhang Shang, Xing Qin, Hongmei Cao, Jingxia Dang
PURPOSE: The reference values of long exercise test are inconsistent in previous studies. Our research aims to determine the reference values and improve diagnostic efficiency of long exercise test in periodic paralysis. METHODS: In this study, 100 healthy controls, 35 non-periodic paralysis patients, and 47 patients with periodic paralysis were recruited. The procedures of long exercise test were conducted following McMannis(1986) method. RESULTS: The decrease rate in compound muscle action potential amplitudes was correlated with gender, and it was not influenced by age, height, weight, and exercise...
July 24, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28742527/biotechnological-potential-of-insect-fatty-acid-modifying-enzymes
#14
Michal Tupec, Aleš Buček, Irena Valterová, Iva Pichová
There are more than one million described insect species. This species richness is reflected in the diversity of insect metabolic processes. In particular, biosynthesis of secondary metabolites, such as defensive compounds and chemical signals, encompasses an extraordinarily wide range of chemicals that are generally unparalleled among natural products from other organisms. Insect genomes, transcriptomes and proteomes thus offer a valuable resource for discovery of novel enzymes with potential for biotechnological applications...
July 25, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28742403/lpxc-inhibitors-a-patent-review-2010-2016
#15
Dmitrii V Kalinin, Ralph Holl
The Zn(2+)-dependent deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising target for the development of antibiotics selectively combating Gram-negative pathogens. Researchers from industry and academia have synthesized structurally diverse LpxC inhibitors, exhibiting different LpxC inhibitory and antibacterial activities. Areas covered: A brief introduction into the structure and function of LpxC, showing its suitability as antibacterial target, along with the structures of several reported LpxC inhibitors, is given...
July 25, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28742384/antiproliferative-effects-of-red-and-white-wine-extracts-in-pc-3-prostate-cancer-cells
#16
Roxane Tenta, Elizabeth Fragopoulou, Magafoula Tsoukala, Marianna Xanthopoulou, Maria Skyrianou, Harris Pratsinis, Dimitris Kletsas
Experimental and epidemiological studies have shown that antioxidant polyphenols can act as chemopreventive agents against prostate cancer. Cabernet Sauvignon and Rombola wine were extracted in order to obtain fractions containing different classes of compounds. All extracts inhibited the androgen-insensitive human prostate cancer cells (PC-3) proliferation in a dose-dependent manner. The most potent compounds were selected to be further tested.Treatment of PC-3 cells with the selected wine extracts marginally increased the cell distribution in S phase, while producing a remarkable induction of autophagy...
July 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28742374/high-throughput-analysis-identifying-drugs-that-regulate-apolipoprotein-a-i-synthesis
#17
Michael J Haas, Luisa Onstead-Haas, William Kurban, Harshit Shah, Monica Plazarte, Ayham Chamseddin, Arshag D Mooradian
Apolipoprotein A-I (apo A-I) is the primary antiatherogenic protein in high-density lipoprotein (HDL). Despite the controversy as to the clinical effectiveness of raising HDL, the search is ongoing for safe and effective drugs that increase HDL and apo A-I levels. To identify novel compounds that can increase hepatic apo A-I production, two drug libraries were screened. The NIH clinical collection (NCC) and the NIH clinical collection 2 (NCC2) were purchased from Evotec (San Francisco, CA). The NCC library contains 446 compounds and the NCC2 library contains 281 compounds, all dissolved in dimethylsulfoxide at a concentration of 10 mM...
July 25, 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/28742370/a-community-grows-around-the-geysering-world-of-enceladus
#18
Carolyn C Porco
The discovery by NASA's Cassini mission at Saturn in 2005 of a large plume of material erupting from the south polar terrain of Enceladus, sourced within a subsurface ocean of salty liquid water laced with organic compounds, has brought together scientists from a diverse range of disciplines over the last decade to evaluate this small moon's potential for extraterrestrial life. The collection of papers published today in Astrobiology, as the mission draws to a close, is the outcome of our most recent meeting at UC Berkeley in June 2016...
July 25, 2017: Astrobiology
https://www.readbyqxmd.com/read/28742352/stereocontrolled-nucleophilic-addition-to-five-membered-oxocarbenium-ions-directed-by-the-protecting-groups-application-to-the-total-synthesis-of-varitriol-and-of-two-diastereoisomers-thereof
#19
Alma Sánchez-Eleuterio, William Hernán García-Santos, Howard Díaz-Salazar, Marcos Hernández-Rodríguez, Alejandro Cordero-Vargas
A stereodivergent C-glycosidation of carbohydrate-derived lactones can be mediated by the protecting groups, and applied to the total synthesis of (+)-varitriol and of two diastereoisomers thereof, which represent an unprecedent use of the protecting groups in the synthesis of a naturally occurring compound. In particular, the stereoselective nucleophile attack for 2,3-trans substituted five-membered ring oxocarbenium ions is strongly influenced by the presence of aromatic rings in the protecting groups. According to quantum chemical calculations, the stereoselectvity depends on the π-π interactions between the aromatic ring of the C-2 protecting group with the exocyclic triple bond and the oxocarbenium ion...
July 25, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28742351/materials-screening-for-the-discovery-of-new-half-heuslers-machine-learning-versus-ab-initio-methods
#20
Fleur Legrain, Jesús Carrete, Ambroise van Roekeghem, Georg K H Madsen, Natalio Mingo
Machine learning (ML) is increasingly becoming a helpful tool in the search for novel functional compounds. Here we use classification via random forests to predict the stability of half-Heusler (HH) compounds, using only experimentally reported compounds as a training set. Cross-validation yields an excellent agreement between the fraction of compounds classified as stable and the actual fraction of truly stable compounds in the ICSD. The ML model is then employed to screen 71,178 different 1:1:1 compositions, yielding 481 likely stable candidates...
July 25, 2017: Journal of Physical Chemistry. B
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