Ruth Tevlin, Michelle Griffin, Kellen Chen, Michael Januszyk, Nick Guardino, Amanda Spielman, Shannon Walters, Garry Evan Gold, Charles K F Chan, Geoffrey C Gurtner, Derrick C Wan, Michael T Longaker
Mandibular distraction osteogenesis (DO) is mediated by skeletal stem cells (SSCs) in mice, which enact bone regeneration via neural crest re-activation. As peripheral nerves are essential to progenitor function during development and in response to injury, we questioned if denervation impairs mandibular DO. C57Bl6 mice were divided into two groups: DO with a segmental defect in the inferior alveolar nerve (IAN) at the time of mandibular osteotomy ("DO Den") and DO with IAN intact ("DO Inn"). DO Den demonstrated significantly reduced histological and radiological osteogenesis relative to DO Inn...
February 6, 2023: Scientific Reports