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https://www.readbyqxmd.com/read/29441493/model-based-economic-evaluation-of-treatments-for-depression-a-systematic-literature-review
#1
REVIEW
Spyros Kolovos, Judith E Bosmans, Heleen Riper, Karine Chevreul, Veerle M H Coupé, Maurits W van Tulder
BACKGROUND: An increasing number of model-based studies that evaluate the cost effectiveness of treatments for depression are being published. These studies have different characteristics and use different simulation methods. OBJECTIVE: We aimed to systematically review model-based studies evaluating the cost effectiveness of treatments for depression and examine which modelling technique is most appropriate for simulating the natural course of depression. METHODS: The literature search was conducted in the databases PubMed, EMBASE and PsycInfo between 1 January 2002 and 1 October 2016...
September 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29435387/systemic-mastocytosis-the-difficult-patient-with-a-rare-disease-case-presentation-and-brief-review
#2
Daniel H Desmond, Mark G Carmichael
Mastocytosis is a rare process involving the activation and accumulation of clonal mast cells categorized by cutaneous or systemic involvement. Although the diagnosis of cutaneous disease can be straightforward and confirmed via skin biopsy, systemic disease mimics more common disease processes making diagnosis a challenge. The widespread physiologic distribution of mast cells causes a variety of symptoms with aberrant expression including fatigue, headache, depression, dyspnea, dyspepsia, nausea, and abdominal pain...
February 2018: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29417104/gas-phase-kinetics-of-the-oh-ch3ch2oh-reaction-at-temperatures-of-the-interstellar-medium-t-21-107-k
#3
A J Ocaña, S Blázquez, B Ballesteros, A Canosa, M Antiñolo, J Albaladejo, E Jiménez
Ethanol, CH3CH2OH, has been unveiled in the interstellar medium (ISM) by radioastronomy and it is thought to be released into the gas phase after the warm-up phase of the grain surface, where it is formed. Once in the gas phase, it can be destroyed by different reactions with atomic and radical species, such as hydroxyl (OH) radicals. The knowledge of the rate coefficients of all these processes at temperatures of the ISM is essential in the accurate interpretation of the observed abundances. In this work, we have determined the rate coefficient for the reaction of OH with CH3CH2OH (k(T)) between 21 and 107 K by employing the pulsed and continuous CRESU (Cinétique de Réaction en Ecoulement Supersonique Uniforme, which means Reaction Kinetics in a Uniform Supersonic Flow) technique...
February 8, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29395131/a-new-continuous-sliding-mode-control-approach-with-actuator-saturation-for-control-of-2-dof-helicopter-system
#4
S P Sadala, B M Patre
The 2-degree of freedom (DOF) helicopter system is a typical higher-order, multi-variable, nonlinear and strong coupled control system. The helicopter dynamics also includes parametric uncertainties and is subject to unknown external disturbances. Such complicated system requires designing a sophisticated control algorithm that can handle these difficulties. This paper presents a new robust control algorithm which is a combination of two continuous control techniques, composite nonlinear feedback (CNF) and super-twisting control (STC) methods...
January 30, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29382740/a-plastidial-pantoate-transporter-with-a-potential-role-in-pantothenate-synthesis
#5
Lili Huang, Michal Pyc, Saleh Alseekh, Donald R McCarty, Valérie de Crécy-Lagard, Jesse F Gregory, Christopher S Henry, Alisdair R Fernie, Robert T Mullen, Andrew D Hanson
The pantothenate (vitamin B5) synthesis pathway in plants is not fully defined because the sub-cell-ular site of its ketopantoate → pantoate reduction step is unclear. However, the pathway is known to be split between cytosol, mit-o-chondria, and potentially plastids, and inferred to involve mitochondrial or plast-idial transport of ketopantoate or pantoate. No proteins that mediate these transport steps have been identified. Compar-at-ive genomic and transcriptomic analyses identified Arabidopsis thal-iana BASS1 (At1g78560) and its maize ( Zea mays ) ortholog as candidates for such a transport role...
January 30, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29349743/chemically-and-size-resolved-particulate-matter-dry-deposition-on-stone-and-surrogate-surfaces-inside-and-outside-the-low-emission-zone-of-milan-application-of-a-newly-developed-deposition-box
#6
Luca Ferrero, Marco Casati, Lara Nobili, Luca D'Angelo, Grazia Rovelli, Giorgia Sangiorgi, Cristiana Rizzi, Maria Grazia Perrone, Antonio Sansonetti, Claudia Conti, Ezio Bolzacchini, Elena Bernardi, Ivano Vassura
The collection of atmospheric particles on not-filtering substrates via dry deposition, and the subsequent study of the particle-induced material decay, is trivial due to the high number of variables simultaneously acting on the investigated surface. This work reports seasonally resolved data of chemical composition and size distribution of particulate matter deposed on stone and surrogate surfaces obtained using a new method, especially developed at this purpose. A "Deposition Box" was designed allowing the particulate matter dry deposition to occur selectively removing, at the same time, variables that can mask the effect of airborne particles on material decay...
January 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29341334/incidence-and-prognostic-impact-of-cytogenetic-aberrations-in-patients-with-systemic-mastocytosis
#7
Nicole Naumann, Mohamad Jawhar, Juliana Schwaab, Sebastian Kluger, Johannes Lübke, Georgia Metzgeroth, Henning D Popp, Nada Khaled, Hans-Peter Horny, Karl Sotlar, Peter Valent, Claudia Haferlach, Gudrun Göhring, Brigitte Schlegelberger, Manja Meggendorfer, Wolf-Karsten Hofmann, Nicholas C P Cross, Andreas Reiter, Alice Fabarius
The clinical behavior of systemic mastocytosis (SM) is strongly associated with activating mutations in KIT (D816V in >80% of cases), with the severity of the phenotype influenced by additional somatic mutations, e.g. in SRSF2, ASXL1 or RUNX1. Complex molecular profiles are frequently associated with the presence of an associated hematologic neoplasm (AHN) and an unfavorable clinical outcome. However, little is known about the incidence and prognostic impact of cytogenetic aberrations. We analyzed cytogenetic and molecular characteristics of 109 patients (KIT D816V+, n=102, 94%) with indolent (ISM, n=26) and advanced SM (n=83) with (n=73, 88%) or without AHN...
January 17, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29337546/a-mitochondria-specific-fluorescent-probe-for-visualizing-endogenous-hydrogen-cyanide-fluctuations-in-neurons
#8
Lingliang Long, Meiyu Huang, Ning Wang, Yanjun Wu, Kun Wang, Aihua Gong, Zhijian Zhang, Jonathan L Sessler
An ability to visualize HCN in mitochondria in real time may permit additional insights into the critical toxicological and physiological roles this classic toxin plays in living organ-isms. Herein, we report a mitochondria-specific coumarin pyrrolidinium-derived fluorescence probe (MRP1) that permits the real time ratiometric imaging of HCN in living cells. The response is specific, sensitive (detection limit is ca. 65.6 nM), rapid (within 1 s), and reversible. Probe MRP1 contains a ben-zyl chloride subunit designed to enhance retention within the mitochondria under conditions where the mitochondria membrane potential is eliminated...
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29331029/characterization-of-cd34-hematopoietic-cells-in-systemic-mastocytosis-potential-role-in-disease-dissemination
#9
A Mayado, C Teodosio, N Dasilva-Freire, M Jara-Acevedo, A C Garcia-Montero, I Álvarez-Twose, L Sánchez-Muñoz, A Matito, C Caldas, J I Muñoz-González, A Henriques, J I Sánchez-Gallego, L Escribano, A Orfao
BACKGROUND: Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs-), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation-associated compartments of bone marrow (BM) and peripheral blood (PB) CD34 + hematopoietic precursors (HPC) in ISM and identified the specific PB cell compartments that carry this mutation...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29328063/immune-loss-as-a-driver-of-coexistence-during-host-phage-coevolution
#10
Jake L Weissman, Rayshawn Holmes, Rodolphe Barrangou, Sylvain Moineau, William F Fagan, Bruce Levin, Philip L F Johnson
Bacteria and their viral pathogens face constant pressure for augmented immune and infective capabilities, respectively. Under this reciprocally imposed selective regime, we expect to see a runaway evolutionary arms race, ultimately leading to the extinction of one species. Despite this prediction, in many systems host and pathogen coexist with minimal coevolution even when well-mixed. Previous work explained this puzzling phenomenon by invoking fitness tradeoffs, which can diminish an arms race dynamic. Here we propose that the regular loss of immunity by the bacterial host can also produce host-phage coexistence...
January 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29328062/cyanobacterial-photosynthesis-under-sulfidic-conditions-insights-from-the-isolate-leptolyngbya-sp-strain-hensonii
#11
Trinity L Hamilton, Judith M Klatt, Dirk de Beer, Jennifer L Macalady
We report the isolation of a pinnacle-forming cyanobacterium isolated from a microbial mat covering the sediment surface at Little Salt Spring-a flooded sinkhole in Florida with a perennially microoxic and sulfidic water column. The draft genome of the isolate encodes all of the enzymatic machinery necessary for both oxygenic and anoxygenic photosynthesis, as well as genes for methylating hopanoids at the C-2 position. The physiological response of the isolate to H2S is complex: (i) no induction time is necessary for anoxygenic photosynthesis; (ii) rates of anoxygenic photosynthesis are regulated by both H2S and irradiance; (iii) O2 production is inhibited by H2S concentrations as low as 1 μM and the recovery rate of oxygenic photosynthesis is dependent on irradiance; (iv) under the optimal light conditions for oxygenic photosynthesis, rates of anoxygenic photosynthesis are nearly double those of oxygenic photosynthesis...
January 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29305050/intraspinal-microstimulation-for-respiratory-muscle-activation
#12
Michael D Sunshine, Comron N Ganji, Paul J Reier, David D Fuller, Chet T Moritz
A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activates diaphragm (DIA) and external intercostal (EIC) motor units. Respiratory muscle electromyography (EMG) was recorded in anesthetized female spinally intact adult rats while a stimulating electrode was advanced ventrally into the spinal cord in 600μm increments...
January 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29304002/a-new-approach-to-design-autonomous-wireless-sensor-node-based-on-rf-energy-harvesting-system
#13
Alex Mouapi, Nadir Hakem
Energy Harvesting techniques are increasingly seen as the solution for freeing the wireless sensor nodes from their battery dependency. However, it remains evident that network performance features, such as network size, packet length, and duty cycle, are influenced by the sum of recovered energy. This paper proposes a new approach to defining the specifications of a stand-alone wireless node based on a Radio-frequency Energy Harvesting System (REHS). To achieve adequate performance regarding the range of the Wireless Sensor Network (WSN), techniques for minimizing the energy consumed by the sensor node are combined with methods for optimizing the performance of the REHS...
January 5, 2018: Sensors
https://www.readbyqxmd.com/read/29289722/effects-of-adalimumab-on-t-helper-17-lymphocyte-and-neutrophil-related-inflammatory-serum-markers-in-patients-with-moderate-to-severe-hidradenitis-suppurativa
#14
D Jiménez-Gallo, R de la Varga-Martínez, L Ossorio-García, C Collantes-Rodríguez, C Rodríguez, M Linares-Barrios
BACKGROUND: T-helper (Th)-17 lymphocytes and neutrophils are the main sources of the proinflammatory cytokines involved in the pathogenesis of hidradenitis suppurativa (HS). OBJECTIVES: This study aims to evaluate the improvement of the inflammatory serum markers (ISM) levels in patients with moderate-to-severe HS who receive adalimumab. METHODS: Nineteen moderate-to-severe HS patients were prospectively recruited. Each of the patients received 40 mg of adalimumab weekly...
December 28, 2017: Cytokine
https://www.readbyqxmd.com/read/29249849/optimal-design-of-a-resonance-based-voltage-boosting-rectifier-for-wireless-power-transmission
#15
Jaemyung Lim, Byunghun Lee, Maysam Ghovanloo
This paper presents the design procedure for a new multi-cycle resonance-based voltage boosting rectifier (MCRR) capable of delivering a desired amount of power to the load (PDL) at a designated high voltage (HV) through a loosely-coupled inductive link. This is achieved by shorting the receiver (Rx) LC-tank for several cycles to harvest and accumulate the wireless energy in the RX inductor before boosting the voltage by breaking the loop and transferring the energy to the load in a quarter cycle. By optimizing the geometries of the transmitter (Tx) and Rx coils and the number of cycles, N, for energy harvesting, through an iterative design procedure, the MCRR can achieve the highest PDL under a given set of design constraints...
February 2018: IEEE Transactions on Industrial Electronics
https://www.readbyqxmd.com/read/29242883/the-anharmonic-quartic-force-field-infrared-spectra-of-hydrogenated-and-methylated-pahs
#16
Cameron J Mackie, Alessandra Candian, Xinchuan Huang, Elena Maltseva, Annemieke Petrignani, Jos Oomens, Wybren Jan Buma, Timothy J Lee, Alexander G G M Tielens
Polycyclic aromatic hydrocarbons (PAHs) have been shown to be ubiquitous in a large variety of distinct astrophysical environments and are therefore of great interest to astronomers. The majority of these findings are based on theoretically predicted spectra, which make use of scaled DFT harmonic frequencies for band positions and the double harmonic approximation for intensities. However, these approximations have been shown to fail at predicting high-resolution gas-phase infrared spectra accurately, especially in the CH-stretching region (2950-3150 cm-1, 3 μm)...
December 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29192905/microbial-life-on-a-sand-grain-from-bulk-sediment-to-single-grains
#17
David Probandt, Thilo Eickhorst, Andreas Ellrott, Rudolf Amann, Katrin Knittel
Globally, marine surface sediments constitute a habitat for estimated 1.7 × 1028 prokaryotes. For benthic microbial community analysis, usually, several grams of sediment are processed. In this study, we made the step from bulk sediments to single sand grains to address the microbial community directly in its micro-habitat: the individual bacterial diversity on 17 sand grains was analyzed by 16S ribosomal RNA gene sequencing and visualized on sand grains using catalyzed reporter deposition fluorescence in situ hybridization...
December 1, 2017: ISME Journal
https://www.readbyqxmd.com/read/29192904/specific-substrate-driven-changes-in-human-faecal-microbiota-composition-contrast-with-functional-redundancy-in-short-chain-fatty-acid-production
#18
Nicole Reichardt, Maren Vollmer, Grietje Holtrop, Freda M Farquharson, Daniel Wefers, Mirko Bunzel, Sylvia H Duncan, Janice E Drew, Lynda M Williams, Graeme Milligan, Thomas Preston, Douglas Morrison, Harry J Flint, Petra Louis
The diet provides carbohydrates that are non-digestible in the upper gut and are major carbon and energy sources for the microbial community in the lower intestine, supporting a complex metabolic network. Fermentation produces the short-chain fatty acids (SCFAs) acetate, propionate and butyrate, which have health-promoting effects for the human host. Here we investigated microbial community changes and SCFA production during in vitro batch incubations of 15 different non-digestible carbohydrates, at two initial pH values with faecal microbiota from three different human donors...
December 1, 2017: ISME Journal
https://www.readbyqxmd.com/read/29192903/rare-symbionts-may-contribute-to-the-resilience-of-coral-algal-assemblages
#19
Maren Ziegler, Víctor M Eguíluz, Carlos M Duarte, Christian R Voolstra
The association between corals and photosynthetic dinoflagellates (Symbiodinium spp.) is the key to the success of reef ecosystems in highly oligotrophic environments, but it is also their Achilles' heel due to its vulnerability to local stressors and the effects of climate change. Research during the last two decades has shaped a view that coral host-Symbiodinium pairings are diverse, but largely exclusive. Deep sequencing has now revealed the existence of a rare diversity of cryptic Symbiodinium assemblages within the coral holobiont, in addition to one or a few abundant algal members...
December 1, 2017: ISME Journal
https://www.readbyqxmd.com/read/29171840/what-intrinsic-and-extrinsic-factors-explain-the-stoichiometric-diversity-of-aquatic-heterotrophic-bacteria
#20
Casey M Godwin, James B Cotner
The elemental content of microbial communities is dependent upon the physiology of constituent populations, yet ecological stoichiometry has made slow progress toward identifying predictors of how species and strains change the elemental content of their biomass in response to the stoichiometry of elements in resources. We asked whether the elemental content of aquatic bacteria, especially flexibility in elemental content, could be predicted by their phylogeny, maximum growth rate or lake productivity. We examined 137 isolates using chemostats and found that strains differed substantially in how the carbon:nitrogen:phosphorus ratios (C:N:P) in their biomass responded to P-sufficient and P-limiting conditions...
November 24, 2017: ISME Journal
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