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Chieh Kao, Ritu Chandna, Abhijeet Ghode, Charlotte Dsouza, Mo Chen, Andreas Larsson, Siau Hoi Lim, Minjun Wang, Zhonglian Cao, Yizhun Zhu, Ganesh S Anand, Ruowen Ge
Glucose regulated protein 78 kDa (GRP78) is a recently emerged target for cancer therapy and a biomarker for cancer prognosis. Overexpression of GRP78 is observed in many types of cancers, with the cell-surface GRP78 being preferentially present in cancer cells and cancer blood vessel endothelial cells. Isthmin (ISM) is a secreted high-affinity proapoptotic protein ligand of cell-surface GRP78 that suppresses angiogenesis and tumor growth in mice. The C-terminal AMOP (adhesion-associated domain in MUC4 and other proteins) domain of ISM is critical in mediating its interaction with human umbilical vein endothelial cells (HUVECs)...
June 12, 2018: EBioMedicine
Amirali Toossi, Dirk G Everaert, Peter Seres, Jacob L Jaremko, Kevin Robinson, C Chris Kao, Peter E Konrad, Vivian K Mushahwar
OBJECTIVE The overall goal of this study was to develop an image-guided spinal stereotactic setup for intraoperative intraspinal microstimulation (ISMS). System requirements were as follows: 1) ability to place implants in various segments of the spinal cord, targeting the gray matter with a < 0.5-mm error; 2) modularity; and 3) compatibility with standard surgical tools. METHODS A spine-mounted stereotactic system was developed, optimized, and tested in pigs. The system consists of a platform supporting a micromanipulator with 6 degrees of freedom...
June 15, 2018: Journal of Neurosurgery. Spine
Mohammadkarim Bahadori, Ehsan Teymourzadeh, Hamidreza Tajik, Ramin Ravangard, Mehdi Raadabadi, Seyed Mojtaba Hosseini
Purpose Strategic planning is the best tool for managers seeking an informed presence and participation in the market without surrendering to changes. Strategic planning enables managers to achieve their organizational goals and objectives. Hospital goals, such as improving service quality and increasing patient satisfaction cannot be achieved if agreed strategies are not implemented. The purpose of this paper is to investigate the factors affecting strategic plan implementation in one teaching hospital using interpretive structural modeling (ISM)...
June 11, 2018: International Journal of Health Care Quality Assurance
Yi-Ting Chen, Indu Sarangadharan, Revathi Sukesan, Ching-Yen Hseih, Geng-Yen Lee, Jen-Inn Chyi, Yu-Lin Wang
Lead ion selective membrane (Pb-ISM) coated AlGaN/GaN high electron mobility transistors (HEMT) was used to demonstrate a whole new methodology for ion-selective FET sensors, which can create ultra-high sensitivity (-36 mV/log [Pb2+ ]) surpassing the limit of ideal sensitivity (-29.58 mV/log [Pb2+ ]) in a typical Nernst equation for lead ion. The largely improved sensitivity has tremendously reduced the detection limit (10-10  M) for several orders of magnitude of lead ion concentration compared to typical ion-selective electrode (ISE) (10-7  M)...
May 29, 2018: Scientific Reports
Arra Yugander, Raman M Sundaram, Kuldeep Singh, Duraisamy Ladhalakshmi, Lella V Subba Rao, Maganti Sheshu Madhav, Jyothi Badri, Madamsetty Srinivas Prasad, Gouri Sankar Laha
Bacterial blight (BB) in rice caused by Xanthomonas oryzae pv. oryzae (Xoo) is a major global production constraint, particularly in irrigated and rain-fed lowland areas. Improved Samba Mahsuri (ISM) is an elite, high-yielding, fine-grain type, BB-resistant rice variety possessing three BB-resistant genes (Xa21, xa13 and xa5) and is highly popular in the southern parts of India. As the BB pathogen is highly dynamic and the evolution of pathogen virulence against the deployed resistance genes is common, we added a novel BB-resistant gene, Xa38, into ISM through marker-assisted backcross breeding (MABB) to increase the spectrum and durability of BB resistance...
2018: PloS One
Priyadarshee Abhishek, S Haque Nizamie, Indu Dubey, Nishant Goyal, Sai Krishna Tikka, Hariom Pachori, Devvarta Kumar, Mohammed Zia Ul Haq Katshu
BACKGROUND: Patients with schizophrenia demonstrate difficulty differentiating internally-generated from externally-generated events. An excessive deployment of attention to external events as well as poor processing of self-generated events has been proposed to explain this misattribution. This study was done to understand the neurophysiological basis of source monitoring bias in schizophrenia. METHODS: Seventeen patients and fourteen healthy controls completed a two-stage source monitoring task involving solving a three-letter jumbled word either by the participant or a computer following which they had to identify the correct source of the word - solved by self (internal source monitoring, ISM) or by computer (external source monitoring, ESM) - while EEG was recorded...
May 15, 2018: Asian Journal of Psychiatry
Cristina Ocaña, Natalia Abramova, Andrey Bratov, Tom Lindfors, Johan Bobacka
We report here the fabrication of solid-contact calcium-selective electrodes (Ca2+ -SCISEs) made of a polyurethane acrylate ion-selective membrane (ISM) that was covalently attached to the underlying ion-to-electron transducer (solid-contact). Methacrylate-functionalized poly(3,4-ethylenedioxythiophene) (Meth-PEDOT) and Meth-PEDOT films containing either multiwalled carbon nanotubes (MWCNT) or carboxylated MWCNT (cMWCNT) were used as solid contacts. The solid contacts were deposited by drop-casting on screen-printed electrodes and characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and potentiometry...
August 15, 2018: Talanta
Anna-Maria Marbà-Ardébol, Jörn Emmerich, Michael Muthig, Peter Neubauer, Stefan Junne
BACKGROUND: The morphology of yeast cells changes during budding, depending on the growth rate and cultivation conditions. A photo-optical microscope was adapted and used to observe such morphological changes of individual cells directly in the cell suspension. In order to obtain statistically representative samples of the population without the influence of sampling, in situ microscopy (ISM) was applied in the different phases of a Saccharomyces cerevisiae batch cultivation. The real-time measurement was performed by coupling a photo-optical probe to an automated image analysis based on a neural network approach...
May 15, 2018: Microbial Cell Factories
Ehsan Rouhani, Abbas Erfanian
OBJECTIVE: The problem of motor control using intraspinal microstimulation (ISMS) can be approached at two levels of the motor system: individual muscles (motor pools) and motor primitives. The major challenges of direct ISMS at the level of individual muscle are the number of electrodes that are required to be implanted in order to recruit all muscles involving the motion and the muscle selectivity. One solution to cope with these problems is the control of movement generated by appropriate combination of the movement primitives...
May 15, 2018: Journal of Neural Engineering
Lin Wei Han, Xiao Fu, Yan Yan, Chen Xing Wang, Gang Wu
In order to determine the cumulative eco-environmental effect of coal-electricity integration, we selected 29 eco-environmental factors including different development and construction activities of coal-electricity integration, soil, water, atmospheric conditions, biology, landscape, and ecology. Literature survey, expert questionnaire and interview were conducted to analyze the interactive relationships between different factors. The structure and correlations between the eco-environmental factors influenced by coal-electricity integration activities were analyzed using interpretive structural modeling (ISM) and the cumulative eco-environment effect of development and construction activities was determined...
May 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Sarah E Mondello, Michael D Sunshine, Amanda E Fischedick, Sam J Dreyer, Gregory D Horwitz, Polina Anikeeva, Philip J Horner, Chet T Moritz
Electrical intraspinal microstimulation (ISMS) at various sites along the cervical spinal cord permits forelimb muscle activation, elicits complex limb movements, and may enhance functional recovery after spinal cord injury (SCI). Here, we explore optogenetic spinal stimulation (OSS) as a less invasive and cell-type specific alternative to ISMS. To map forelimb muscle activation by OSS in rats, adeno-associated viruses (AAV) carrying the blue-light sensitive ion channels channelrhodopsin-2 (ChR2) and Chronos were injected into the cervical spinal cord at different depths and volumes...
May 2, 2018: Journal of Neurophysiology
Ajay Gajanan Bhave, Declan Conway, Suraje Dessai, David A Stainforth
Decision-Making Under Uncertainty (DMUU) approaches have been less utilized in developing countries than developed countries for water resources contexts. High climate vulnerability and rapid socioeconomic change often characterize developing country contexts, making DMUU approaches relevant. We develop an iterative multi-method DMUU approach, including scenario generation, coproduction with stakeholders and water resources modeling. We apply this approach to explore the robustness of adaptation options and pathways against future climate and socioeconomic uncertainties in the Cauvery River Basin in Karnataka, India...
February 2018: Water Resources Research
Karen Gertz, Ria Uhlemann, Anna Foryst-Ludwig, Ruben Marquina Barrientos, Kai Kappert, Christa Thöne-Reineke, Pierre Djoufack, Clemens Kirschbaum, Klaus B Fink, Andreas Heinz, Ulrich Kintscher, Matthias Endres, Golo Kronenberg
Evidence for a critical pathophysiological role of aberrant cytoskeletal dynamics is being uncovered in a growing number of neuropsychiatric syndromes. A sedentary lifestyle as well as overt psychopathology is prevalent in patients with the metabolic syndrome. Using mice deficient in gelsolin (Gsn-/- ), a crucial actin-severing protein, we here investigated reduced actin turnover as a potential common driver of metabolic disturbances, sedentary behavior, and an anxious/depressive phenotype. Gelsolin deficiency resulted in reduced lifespan...
August 2018: Experimental Neurology
Abhrajyoti Tarafdar, Tarun Kanti Sarkar, Sourav Chakraborty, Alok Sinha, Reginald E Masto
Adsorption-synergic biodegradation of a model PAH (phenanthrene, Phe) on MWCNT buckypaper surface with a potential PAH biodegrading bacterial strain Bacillus thuringiensis AT.ISM.11 has been studied in aqueous medium. Adsorption of Phe on buckypaper follows Dubinin-Ashtakhov model (R2 = 0.9895). MWCNT generally exerts toxicity to microbes but adsorbed layer of Phe prevents the direct contact between MWCNT and bacterial cell wall. FESEM study suggests that formation of biofilms occurred on buckypaper. Lower layer cells are disrupted and flattened as they are in direct contact with MWCNT but the upper layer cells of the developed biofilm are fully intact and functional...
August 15, 2018: Ecotoxicology and Environmental Safety
Therese I Poirier, Connie Stamper-Carr
No abstract text is available yet for this article.
March 2018: American Journal of Pharmaceutical Education
George Kassianos, Ernest Kuchar, Aneta Nitsch-Osuch, Jan Kyncl, Andrey Galev, Isme Humolli, Oana Falup-Pecurariu, Angus Thomson, Christina Klein, Gaëlle Vallée-Tourangeau
BACKGROUND: Annual vaccination is the most effective way to prevent and control the health and economic burden caused by seasonal influenza. Healthcare workers (HCWs) play a crucial role in vaccine acceptance and advocacy for their patients. This study explored the drivers of HCWs' vaccine acceptance and advocacy in six European countries. METHODS: Healthcare workers (mainly general practitioners, specialist physicians, and nurses) voluntarily completed a questionnaire in Bulgaria (N = 485), Czech Republic (N = 518), Kosovo (N = 466), Poland (N = 772), Romania (N = 155), and the United Kingdom (N = 80)...
March 28, 2018: Vaccine
Carme Huguet, Joyanto Routh, Susanne Fietz, Mahjoor Ahmad Lone, M S Kalpana, Prosenjit Ghosh, Augusto Mangini, Vikash Kumar, Ravi Rangarajan
High-resolution paleoclimate data on stable isotopes in a stalagmite were coupled to glycerol dialkyl glycerol tetraethers (GDGTs). The Indian Summer Monsoon (ISM) transitioned from limited rainfall during the Last Glacial Maximum (LGM) to intense precipitation during early Holocene (22 to 6 ka). This was associated with changes in stalagmite growth, abundance of branched (br) and isoprenoid (iso) GDGTs, as well as δ18 O, δ13 C, Sr/Ca and GDGT-derived signals providing both temperature and moisture information...
March 29, 2018: Scientific Reports
Huawei Liu, Baoqing Li, Xiaobing Yuan, Qianwei Zhou, Jingchang Huang
Parameters estimation of sequential movement events of vehicles is facing the challenges of noise interferences and the demands of portable implementation. In this paper, we propose a robust direction-of-arrival (DOA) estimation method for the sequential movement events of vehicles based on a small Micro-Electro-Mechanical System (MEMS) microphone array system. Inspired by the incoherent signal-subspace method (ISM), the method that is proposed in this work employs multiple sub-bands, which are selected from the wideband signals with high magnitude-squared coherence to track moving vehicles in the presence of wind noise...
March 27, 2018: Sensors
Muluken Yayeh, Shimelis Dagnachew, Meseret Tilahun, Achenef Melaku, Tadegegn Mitiku, Mohamed Yesuf, Zewdu Seyoum, Habtamu Kefyalew
The current study was undertaken from December 2015 to May 2016 with the aim of determining and comparing the pathogenicity and response to diminazene aceturate (DA) and isometamidium chloride (ISM) treatment in experimentally infected mice with trypanosome isolates from Jawi and Birsheleko areas of northwest Ethiopia. A total of 42 mice were used for the experiment. These mice were randomly assigned in to 7 groups of 6 mice per group. Three of the groups (Group 1, 4 and 5) were inoculated with trypanosome isolated from Jawi and three other groups (Group-2, 6 and 7) were inoculated with trypanosome isolated from Birsheleko and the remaining one group (Group 3) was negative control...
February 2018: Heliyon
Eric Michoulier, Jennifer A Noble, Aude Simon, Joëlle Mascetti, Céline Toubin
Polycyclic Aromatic Hydrocarbons (PAHs) are a family of molecules which represent the best candidates to explain the observation of one set of features in the Interstellar Medium (ISM): the Aromatic Interstellar Bands (AIBs). They could also contribute to the Diffuse Interstellar Bands (DIBs). In dense molecular clouds, PAHs may condense onto interstellar grains, contributing to the complex chemistry occurring in their icy mantles, composed essentially of water. In this context, the adsorption of various aromatic molecules, from benzene to ovalene, on different ices - both amorphous and crystalline - is investigated by means of classical molecular dynamics simulations...
March 28, 2018: Physical Chemistry Chemical Physics: PCCP
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